The experimental work was performed in the Neuroscience Research Center, Department of Neurophysiology at Charité-Medical School, Humboldt University of Berlin during the years 2002 - 2005. Data analysis and manuscript writing were accomplished in Biblioteka National-Santiago de Chile and Lane Medical Library at Stanford University, CA, USA.

First of all, I am greatly indebted to Prof. Dr. Uwe Heinemann for giving me the opportunity to work in Johannes Müller Institute of Neurophysiology and to join Graduate School (GRK) 283. I truly appreciate his valuable criticism and encouragement during my work in Berlin.

I would like to thank Prof. Dr. Wolfgang Müller for accepting me in his group, his guidance during my work in NWFZ and expert comments for improving the manuscript.

Thanks to all my colleagues from the former AG Müller: Dr. Philppe Alix, Dr. Scott Adams, Dr. Ivan Raginov, Dr. Jochen Winterer, Siarhei Kirko, Adrij Volynets, Dr. Denis Bragin, Pamela Liebig and Sabrina Rötger for the unbelievable working atmosphere, helpful discussions and support at everyday work.

I thank PD Dr.Stephan Baader, Institute for Anatomy, Friedrich Wilhelm University of Rhein, Bonn for generously providing the Kv1.4, Kv4.2 and EGFP cDNAs.

I would also like to thank our administrative assistants - Mrs. Sonja Frosinski, Dr. Katrin Schultze and Mrs. Margaret Franke for their essential help through the years.

Thanks belong to all my student colleagues and friends from GRK 238 for their collaboration and ever friendly attitude.

I’m grateful to Ass. Prof. Dr.Virjinia Doltchinkova from Sofia University and Prof. Dr. Hermann Berg from Saxonian Academy of Sciences for encouraging me to start PhD and for continuous moral support.

I thank my family for their years-long patience and support.

Finally, but not last, I owe my warmest thanks to Dr. Albrecht Stroh for his everlasting support and encouragement during these years.

Herzlichen Dank!

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