<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Einfluss der Neutralen Endopeptidase auf Alzheimersche Erkrankung, Alkoholkonsum und Adipositas</cms:entry><cms:entry id="I_Ref121759619" part="front" ref="I_Ref121759619" type="link"/><cms:entry type="author">Matthias Becker</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">I</cms:entry><cms:entry id="_Toc121401343" part="chapter1" ref="_Toc121401343" type="link"/><cms:entry id="_Toc143257589" part="chapter1" ref="_Toc143257589" type="link"/><cms:entry id="N10089" part="chapter1" ref="N10089" type="citenumber">1</cms:entry><cms:entry id="N100A8" part="chapter1" ref="N100A8" type="citenumber">2</cms:entry><cms:entry id="N100E0" part="chapter1" ref="N100E0" type="citenumber">3</cms:entry><cms:entry id="N100E3" part="chapter1" ref="N100E3" type="mm">604#333</cms:entry><cms:entry id="I_Ref81242681" part="chapter1" ref="I_Ref81242681" type="link"/><cms:entry id="N100FF" part="chapter1" ref="N100FF" type="citenumber">4</cms:entry><cms:entry id="N1012F" part="chapter1" ref="N1012F" type="citenumber">5</cms:entry><cms:entry id="_Toc121401344" part="chapter1" ref="_Toc121401344" type="link"/><cms:entry id="N1013F" part="chapter1" ref="N1013F" type="section">I - 1.</cms:entry><cms:entry id="_Toc143257590" part="chapter1" ref="_Toc143257590" type="link"/><cms:entry id="_Toc121401345" part="chapter1" ref="_Toc121401345" type="link"/><cms:entry id="N1014D" part="chapter1" ref="N1014D" type="subsection">I - 1.1.</cms:entry><cms:entry id="_Toc143257591" part="chapter1" ref="_Toc143257591" type="link"/><cms:entry id="N10168" part="chapter1" ref="N10168" type="citenumber">6</cms:entry><cms:entry id="_Toc121401346" part="chapter1" ref="_Toc121401346" type="link"/><cms:entry id="_Toc143257592" part="chapter1" ref="_Toc143257592" type="link"/><cms:entry id="N10195" part="chapter1" ref="N10195" type="subsection">I - 1.2.</cms:entry><cms:entry id="N101A7" part="chapter1" ref="N101A7" type="citenumber">7</cms:entry><cms:entry id="N101FD" part="chapter1" ref="N101FD" type="citenumber">8</cms:entry><cms:entry id="_Toc121401347" part="chapter1" ref="_Toc121401347" type="link"/><cms:entry id="_Toc143257593" part="chapter1" ref="_Toc143257593" type="link"/><cms:entry id="N1023E" part="chapter1" ref="N1023E" type="subsection">I - 1.3.</cms:entry><cms:entry id="N1025C" part="chapter1" ref="N1025C" type="citenumber">9</cms:entry><cms:entry id="N1029F" part="chapter1" ref="N1029F" type="citenumber">10</cms:entry><cms:entry id="N102FB" part="chapter1" ref="N102FB" type="citenumber">11</cms:entry><cms:entry id="N102FE" part="chapter1" ref="N102FE" type="table"/><cms:entry id="I_Ref123560110" part="chapter1" ref="I_Ref123560110" type="link"/><cms:entry id="N10451" part="chapter1" ref="N10451" type="mm">603#353</cms:entry><cms:entry id="I_Ref82705863" part="chapter1" ref="I_Ref82705863" type="link"/><cms:entry id="_Toc121401348" part="chapter1" ref="_Toc121401348" type="link"/><cms:entry id="_Toc143257594" part="chapter1" ref="_Toc143257594" type="link"/><cms:entry id="N10475" part="chapter1" ref="N10475" type="subsection">I - 1.4.</cms:entry><cms:entry id="N1047C" part="chapter1" ref="N1047C" type="citenumber">12</cms:entry><cms:entry id="N104B0" part="chapter1" ref="N104B0" type="citenumber">13</cms:entry><cms:entry id="N104CF" part="chapter1" ref="N104CF" type="citenumber">14</cms:entry><cms:entry id="_Toc121401349" part="chapter1" ref="_Toc121401349" type="link"/><cms:entry id="_Toc143257595" part="chapter1" ref="_Toc143257595" type="link"/><cms:entry id="N104E1" part="chapter1" ref="N104E1" type="section">I - 2.</cms:entry><cms:entry id="N104EE" part="chapter1" ref="N104EE" type="citenumber">15</cms:entry><cms:entry id="N104FE" part="chapter1" ref="N104FE" type="citenumber">16</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">II</cms:entry><cms:entry id="_Toc121401350" part="chapter2" ref="_Toc121401350" type="link"/><cms:entry id="_Toc143257596" part="chapter2" ref="_Toc143257596" type="link"/><cms:entry id="N1051B" part="chapter2" ref="N1051B" type="helpercitenumber">16</cms:entry><cms:entry id="_Toc121401351" part="chapter2" ref="_Toc121401351" type="link"/><cms:entry id="N1052E" part="chapter2" ref="N1052E" type="section">II - 1.</cms:entry><cms:entry id="_Toc143257597" part="chapter2" ref="_Toc143257597" type="link"/><cms:entry id="_Toc121401352" part="chapter2" ref="_Toc121401352" type="link"/><cms:entry id="N1053C" part="chapter2" ref="N1053C" type="subsection">II - 1.1.</cms:entry><cms:entry id="_Toc143257598" part="chapter2" ref="_Toc143257598" type="link"/><cms:entry id="N10546" part="chapter2" ref="N10546" type="citenumber">17</cms:entry><cms:entry id="N1055E" part="chapter2" ref="N1055E" type="citenumber">18</cms:entry><cms:entry id="N10561" part="chapter2" ref="N10561" type="mm">604#214</cms:entry><cms:entry id="I_Ref81495259" part="chapter2" ref="I_Ref81495259" type="link"/><cms:entry id="_Toc121401353" part="chapter2" ref="_Toc121401353" type="link"/><cms:entry id="_Toc143257599" part="chapter2" ref="_Toc143257599" type="link"/><cms:entry id="N1058B" part="chapter2" ref="N1058B" type="subsection">II - 1.2.</cms:entry><cms:entry id="N10592" part="chapter2" ref="N10592" type="citenumber">19</cms:entry><cms:entry id="N105BB" part="chapter2" ref="N105BB" type="mm">605#272</cms:entry><cms:entry id="I_Ref81581095" part="chapter2" ref="I_Ref81581095" type="link"/><cms:entry id="N105DA" part="chapter2" ref="N105DA" type="citenumber">20</cms:entry><cms:entry id="N105E4" part="chapter2" ref="N105E4" type="table"/><cms:entry id="I_Ref123473471" part="chapter2" ref="I_Ref123473471" type="link"/><cms:entry id="N10715" part="chapter2" ref="N10715" type="citenumber">21</cms:entry><cms:entry id="N10718" part="chapter2" ref="N10718" type="mm">605#226</cms:entry><cms:entry id="I_Ref81495406" part="chapter2" ref="I_Ref81495406" type="link"/><cms:entry id="N10756" part="chapter2" ref="N10756" type="citenumber">22</cms:entry><cms:entry id="_Toc121401354" part="chapter2" ref="_Toc121401354" type="link"/><cms:entry id="_Toc143257600" part="chapter2" ref="_Toc143257600" type="link"/><cms:entry id="N10767" part="chapter2" ref="N10767" type="subsection">II - 1.3.</cms:entry><cms:entry id="N107A7" part="chapter2" ref="N107A7" type="citenumber">23</cms:entry><cms:entry id="N107E0" part="chapter2" ref="N107E0" type="citenumber">24</cms:entry><cms:entry id="N107E3" part="chapter2" ref="N107E3" type="mm">604#264</cms:entry><cms:entry id="I_Ref81495449" part="chapter2" ref="I_Ref81495449" type="link"/><cms:entry id="_Toc121401355" part="chapter2" ref="_Toc121401355" type="link"/><cms:entry id="_Toc143257601" part="chapter2" ref="_Toc143257601" type="link"/><cms:entry id="N10817" part="chapter2" ref="N10817" type="subsection">II - 1.4.</cms:entry><cms:entry id="N1082F" part="chapter2" ref="N1082F" type="citenumber">25</cms:entry><cms:entry id="N10875" part="chapter2" ref="N10875" type="mm">604#350</cms:entry><cms:entry id="I_Ref81495483" part="chapter2" ref="I_Ref81495483" type="link"/><cms:entry id="N1088D" part="chapter2" ref="N1088D" type="citenumber">26</cms:entry><cms:entry id="_Toc121401356" part="chapter2" ref="_Toc121401356" type="link"/><cms:entry id="_Toc143257602" part="chapter2" ref="_Toc143257602" type="link"/><cms:entry id="N1089F" part="chapter2" ref="N1089F" type="section">II - 2.</cms:entry><cms:entry id="_Toc121401357" part="chapter2" ref="_Toc121401357" type="link"/><cms:entry id="N108AA" part="chapter2" ref="N108AA" type="subsection">II - 2.1.</cms:entry><cms:entry id="_Toc143257603" part="chapter2" ref="_Toc143257603" type="link"/><cms:entry id="_Toc121401358" part="chapter2" ref="_Toc121401358" type="link"/><cms:entry id="I_Ref121759117" part="chapter2" ref="I_Ref121759117" type="link"/><cms:entry id="I_Ref121759307" part="chapter2" ref="I_Ref121759307" type="link"/><cms:entry id="I_Ref121759849" part="chapter2" ref="I_Ref121759849" type="link"/><cms:entry id="I_Ref121759916" part="chapter2" ref="I_Ref121759916" type="link"/><cms:entry id="_Toc143257604" part="chapter2" ref="_Toc143257604" type="link"/><cms:entry id="N108DE" part="chapter2" ref="N108DE" type="subsection">II - 2.2.</cms:entry><cms:entry id="N108E3" part="chapter2" ref="N108E3" type="block">II - 2.2.1.</cms:entry><cms:entry id="N108F0" part="chapter2" ref="N108F0" type="block">II - 2.2.2.</cms:entry><cms:entry id="N108F7" part="chapter2" ref="N108F7" type="citenumber">27</cms:entry><cms:entry id="N10906" part="chapter2" ref="N10906" type="block">II - 2.2.3.</cms:entry><cms:entry id="N10910" part="chapter2" ref="N10910" type="citenumber">28</cms:entry><cms:entry id="N10913" part="chapter2" ref="N10913" type="table"/><cms:entry id="N10A54" part="chapter2" ref="N10A54" type="table"/><cms:entry id="N10B9E" part="chapter2" ref="N10B9E" type="citenumber">29</cms:entry><cms:entry id="_Toc121401359" part="chapter2" ref="_Toc121401359" type="link"/><cms:entry id="_Toc143257605" part="chapter2" ref="_Toc143257605" type="link"/><cms:entry id="N10BB0" part="chapter2" ref="N10BB0" type="subsection">II - 2.3.</cms:entry><cms:entry id="N10BC6" part="chapter2" ref="N10BC6" type="citenumber">30</cms:entry><cms:entry id="N10BCC" part="chapter2" ref="N10BCC" type="table"/><cms:entry id="_Toc121401360" part="chapter2" ref="_Toc121401360" type="link"/><cms:entry id="_Toc143257606" part="chapter2" ref="_Toc143257606" type="link"/><cms:entry id="N10C9F" part="chapter2" ref="N10C9F" type="subsection">II - 2.4.</cms:entry><cms:entry id="N10CA6" part="chapter2" ref="N10CA6" type="citenumber">31</cms:entry><cms:entry id="_Toc121401361" part="chapter2" ref="_Toc121401361" type="link"/><cms:entry id="_Toc143257607" part="chapter2" ref="_Toc143257607" type="link"/><cms:entry id="N10CB7" part="chapter2" ref="N10CB7" type="subsection">II - 2.5.</cms:entry><cms:entry id="_Toc121401362" part="chapter2" ref="_Toc121401362" type="link"/><cms:entry id="_Toc143257608" part="chapter2" ref="_Toc143257608" type="link"/><cms:entry id="N10CCC" part="chapter2" ref="N10CCC" type="subsection">II - 2.6.</cms:entry><cms:entry id="_Toc121401363" part="chapter2" ref="_Toc121401363" type="link"/><cms:entry id="_Toc143257609" part="chapter2" ref="_Toc143257609" type="link"/><cms:entry id="N10CE2" part="chapter2" ref="N10CE2" type="section">II - 3.</cms:entry><cms:entry id="_Toc121401364" part="chapter2" ref="_Toc121401364" type="link"/><cms:entry id="N10CED" part="chapter2" ref="N10CED" type="subsection">II - 3.1.</cms:entry><cms:entry id="_Toc143257610" part="chapter2" ref="_Toc143257610" type="link"/><cms:entry id="N10CF7" part="chapter2" ref="N10CF7" type="citenumber">32</cms:entry><cms:entry id="N10D00" part="chapter2" ref="N10D00" type="mm">605#293</cms:entry><cms:entry id="I_Ref80585934" part="chapter2" ref="I_Ref80585934" type="link"/><cms:entry id="_Toc121401365" part="chapter2" ref="_Toc121401365" type="link"/><cms:entry id="_Toc143257611" part="chapter2" ref="_Toc143257611" type="link"/><cms:entry id="N10D2B" part="chapter2" ref="N10D2B" type="subsection">II - 3.2.</cms:entry><cms:entry id="N10D32" part="chapter2" ref="N10D32" type="citenumber">33</cms:entry><cms:entry id="N10D44" part="chapter2" ref="N10D44" type="block">II - 3.2.1.</cms:entry><cms:entry id="N10D4A" part="chapter2" ref="N10D4A" type="citenumber">34</cms:entry><cms:entry id="N11209" part="chapter2" ref="N11209" type="citenumber">35</cms:entry><cms:entry id="N113FD" part="chapter2" ref="N113FD" type="citenumber">36</cms:entry><cms:entry id="N1179E" part="chapter2" ref="N1179E" type="block">II - 3.2.2.</cms:entry><cms:entry id="N11A45" part="chapter2" ref="N11A45" type="citenumber">37</cms:entry><cms:entry id="N11B91" part="chapter2" ref="N11B91" type="citenumber">38</cms:entry><cms:entry id="N11F87" part="chapter2" ref="N11F87" type="block">II - 3.2.3.</cms:entry><cms:entry id="_Toc121401366" part="chapter2" ref="_Toc121401366" type="link"/><cms:entry id="_Toc143257612" part="chapter2" ref="_Toc143257612" type="link"/><cms:entry id="N11F9D" part="chapter2" ref="N11F9D" type="subsection">II - 3.3.</cms:entry><cms:entry id="N11FB3" part="chapter2" ref="N11FB3" type="citenumber">39</cms:entry><cms:entry id="N11FB6" part="chapter2" ref="N11FB6" type="mm">604#604</cms:entry><cms:entry id="I_Ref81581242" part="chapter2" ref="I_Ref81581242" type="link"/><cms:entry id="N11FC7" part="chapter2" ref="N11FC7" type="section">II - 4.</cms:entry><cms:entry id="_Toc121401367" part="chapter2" ref="_Toc121401367" type="link"/><cms:entry id="I_Ref121759364" part="chapter2" ref="I_Ref121759364" type="link"/><cms:entry id="I_Ref121759943" part="chapter2" ref="I_Ref121759943" type="link"/><cms:entry id="_Toc143257613" part="chapter2" ref="_Toc143257613" type="link"/><cms:entry id="_Toc121401368" part="chapter2" ref="_Toc121401368" type="link"/><cms:entry id="I_Ref121401426" part="chapter2" ref="I_Ref121401426" type="link"/><cms:entry id="I_Ref121760020" part="chapter2" ref="I_Ref121760020" type="link"/><cms:entry id="N11FF8" part="chapter2" ref="N11FF8" type="subsection">II - 4.1.</cms:entry><cms:entry id="_Toc143257614" part="chapter2" ref="_Toc143257614" type="link"/><cms:entry id="N12002" part="chapter2" ref="N12002" type="citenumber">40</cms:entry><cms:entry id="N12038" part="chapter2" ref="N12038" type="citenumber">41</cms:entry><cms:entry id="N12061" part="chapter2" ref="N12061" type="citenumber">42</cms:entry><cms:entry id="N120DA" part="chapter2" ref="N120DA" type="citenumber">43</cms:entry><cms:entry id="N12107" part="chapter2" ref="N12107" type="citenumber">44</cms:entry><cms:entry id="N12127" part="chapter2" ref="N12127" type="citenumber">45</cms:entry><cms:entry id="N12163" part="chapter2" ref="N12163" type="citenumber">46</cms:entry><cms:entry id="_Toc121401369" part="chapter2" ref="_Toc121401369" type="link"/><cms:entry id="_Toc143257615" part="chapter2" ref="_Toc143257615" type="link"/><cms:entry id="N12198" part="chapter2" ref="N12198" type="subsection">II - 4.2.</cms:entry><cms:entry id="N1219F" part="chapter2" ref="N1219F" type="citenumber">47</cms:entry><cms:entry id="N12227" part="chapter2" ref="N12227" type="mm">604#370</cms:entry><cms:entry id="N1223D" part="chapter2" ref="N1223D" type="citenumber">48</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">III</cms:entry><cms:entry id="_Toc121401370" part="chapter3" ref="_Toc121401370" type="link"/><cms:entry id="_Toc143257616" part="chapter3" ref="_Toc143257616" type="link"/><cms:entry id="N1224F" part="chapter3" ref="N1224F" type="helpercitenumber">48</cms:entry><cms:entry id="_Toc121401371" part="chapter3" ref="_Toc121401371" type="link"/><cms:entry id="N12255" part="chapter3" ref="N12255" type="section">III - 1.</cms:entry><cms:entry id="_Toc143257617" part="chapter3" ref="_Toc143257617" type="link"/><cms:entry id="N1226D" part="chapter3" ref="N1226D" type="citenumber">49</cms:entry><cms:entry id="N1227D" part="chapter3" ref="N1227D" type="citenumber">50</cms:entry><cms:entry id="N122AC" part="chapter3" ref="N122AC" type="citenumber">51</cms:entry><cms:entry id="N122CF" part="chapter3" ref="N122CF" type="subsection">III - 1.1.</cms:entry><cms:entry id="_Toc143257618" part="chapter3" ref="_Toc143257618" type="link"/><cms:entry id="N122DC" part="chapter3" ref="N122DC" type="citenumber">52</cms:entry><cms:entry id="_Toc121401372" part="chapter3" ref="_Toc121401372" type="link"/><cms:entry id="_Toc143257619" part="chapter3" ref="_Toc143257619" type="link"/><cms:entry id="N122F1" part="chapter3" ref="N122F1" type="section">III - 2.</cms:entry><cms:entry id="_Toc121401373" part="chapter3" ref="_Toc121401373" type="link"/><cms:entry id="I_Ref121758975" part="chapter3" ref="I_Ref121758975" type="link"/><cms:entry id="I_Ref121759744" part="chapter3" ref="I_Ref121759744" type="link"/><cms:entry id="N12308" part="chapter3" ref="N12308" type="subsection">III - 2.1.</cms:entry><cms:entry id="_Toc143257620" part="chapter3" ref="_Toc143257620" type="link"/><cms:entry id="_Toc121401374" part="chapter3" ref="_Toc121401374" type="link"/><cms:entry id="_Toc143257621" part="chapter3" ref="_Toc143257621" type="link"/><cms:entry id="N12324" part="chapter3" ref="N12324" type="subsection">III - 2.2.</cms:entry><cms:entry id="N12329" part="chapter3" ref="N12329" type="block">III - 2.2.1.</cms:entry><cms:entry id="N12330" part="chapter3" ref="N12330" type="citenumber">53</cms:entry><cms:entry id="N12335" part="chapter3" ref="N12335" type="block">III - 2.2.2.</cms:entry><cms:entry id="N1233E" part="chapter3" ref="N1233E" type="block">III - 2.2.3.</cms:entry><cms:entry id="N12348" part="chapter3" ref="N12348" type="citenumber">54</cms:entry><cms:entry id="_Toc121401375" part="chapter3" ref="_Toc121401375" type="link"/><cms:entry id="I_Ref121758871" part="chapter3" ref="I_Ref121758871" type="link"/><cms:entry id="I_Ref121759042" part="chapter3" ref="I_Ref121759042" type="link"/><cms:entry id="I_Ref121759697" part="chapter3" ref="I_Ref121759697" type="link"/><cms:entry id="I_Ref121759816" part="chapter3" ref="I_Ref121759816" type="link"/><cms:entry id="_Toc143257622" part="chapter3" ref="_Toc143257622" type="link"/><cms:entry id="N12376" part="chapter3" ref="N12376" type="subsection">III - 2.3.</cms:entry><cms:entry id="N12392" part="chapter3" ref="N12392" type="citenumber">55</cms:entry><cms:entry id="_Toc121401376" part="chapter3" ref="_Toc121401376" type="link"/><cms:entry id="_Toc143257623" part="chapter3" ref="_Toc143257623" type="link"/><cms:entry id="N123C3" part="chapter3" ref="N123C3" type="subsection">III - 2.4.</cms:entry><cms:entry id="_Toc121401377" part="chapter3" ref="_Toc121401377" type="link"/><cms:entry id="_Toc143257624" part="chapter3" ref="_Toc143257624" type="link"/><cms:entry id="N123D8" part="chapter3" ref="N123D8" type="subsection">III - 2.5.</cms:entry><cms:entry id="N123DF" part="chapter3" ref="N123DF" type="citenumber">56</cms:entry><cms:entry id="_Toc121401378" part="chapter3" ref="_Toc121401378" type="link"/><cms:entry id="I_Ref121758532" part="chapter3" ref="I_Ref121758532" type="link"/><cms:entry id="I_Ref121759880" part="chapter3" ref="I_Ref121759880" type="link"/><cms:entry id="_Toc143257625" part="chapter3" ref="_Toc143257625" type="link"/><cms:entry id="N12400" part="chapter3" ref="N12400" type="subsection">III - 2.6.</cms:entry><cms:entry id="N12410" part="chapter3" ref="N12410" type="citenumber">57</cms:entry><cms:entry id="N12413" part="chapter3" ref="N12413" type="mm">289#128</cms:entry><cms:entry id="_Toc121401379" part="chapter3" ref="_Toc121401379" type="link"/><cms:entry id="_Toc143257626" part="chapter3" ref="_Toc143257626" type="link"/><cms:entry id="N12426" part="chapter3" ref="N12426" type="section">III - 3.</cms:entry><cms:entry id="_Toc121401380" part="chapter3" ref="_Toc121401380" type="link"/><cms:entry id="N12434" part="chapter3" ref="N12434" type="subsection">III - 3.1.</cms:entry><cms:entry id="_Toc143257627" part="chapter3" ref="_Toc143257627" type="link"/><cms:entry id="N12449" part="chapter3" ref="N12449" type="citenumber">58</cms:entry><cms:entry id="N1244C" part="chapter3" ref="N1244C" type="table"/><cms:entry id="I_Ref123481830" part="chapter3" ref="I_Ref123481830" type="link"/><cms:entry id="_Toc121401381" part="chapter3" ref="_Toc121401381" type="link"/><cms:entry id="_Toc143257628" part="chapter3" ref="_Toc143257628" type="link"/><cms:entry id="N12703" part="chapter3" ref="N12703" type="subsection">III - 3.2.</cms:entry><cms:entry id="N1270A" part="chapter3" ref="N1270A" type="citenumber">59</cms:entry><cms:entry id="I_Ref123482000" part="chapter3" ref="I_Ref123482000" type="link"/><cms:entry id="N12728" part="chapter3" ref="N12728" type="citenumber">60</cms:entry><cms:entry id="N1272B" part="chapter3" ref="N1272B" type="table"/><cms:entry id="I_Ref125719661" part="chapter3" ref="I_Ref125719661" type="link"/><cms:entry id="_Toc121401382" part="chapter3" ref="_Toc121401382" type="link"/><cms:entry id="_Toc143257629" part="chapter3" ref="_Toc143257629" type="link"/><cms:entry id="N1283D" part="chapter3" ref="N1283D" type="subsection">III - 3.3.</cms:entry><cms:entry id="_Toc121401383" part="chapter3" ref="_Toc121401383" type="link"/><cms:entry id="_Toc143257630" part="chapter3" ref="_Toc143257630" type="link"/><cms:entry id="N12852" part="chapter3" ref="N12852" type="subsection">III - 3.4.</cms:entry><cms:entry id="N1286A" part="chapter3" ref="N1286A" type="citenumber">61</cms:entry><cms:entry id="N1286D" part="chapter3" ref="N1286D" type="mm">604#423</cms:entry><cms:entry id="I_Ref124418633" part="chapter3" ref="I_Ref124418633" type="link"/><cms:entry id="_Toc121401384" part="chapter3" ref="_Toc121401384" type="link"/><cms:entry id="_Toc143257631" part="chapter3" ref="_Toc143257631" type="link"/><cms:entry id="N1288C" part="chapter3" ref="N1288C" type="subsection">III - 3.5.</cms:entry><cms:entry id="N1289E" part="chapter3" ref="N1289E" type="citenumber">62</cms:entry><cms:entry id="N128A1" part="chapter3" ref="N128A1" type="mm">605#187</cms:entry><cms:entry id="I_Ref83882396" part="chapter3" ref="I_Ref83882396" type="link"/><cms:entry id="_Toc121401385" part="chapter3" ref="_Toc121401385" type="link"/><cms:entry id="_Toc143257632" part="chapter3" ref="_Toc143257632" type="link"/><cms:entry id="N128D3" part="chapter3" ref="N128D3" type="subsection">III - 3.6.</cms:entry><cms:entry id="N128DA" part="chapter3" ref="N128DA" type="citenumber">63</cms:entry><cms:entry id="N128E5" part="chapter3" ref="N128E5" type="block">III - 3.6.1.</cms:entry><cms:entry id="N128F3" part="chapter3" ref="N128F3" type="citenumber">64</cms:entry><cms:entry id="N12900" part="chapter3" ref="N12900" type="mm">607#329</cms:entry><cms:entry id="I_Ref124418898" part="chapter3" ref="I_Ref124418898" type="link"/><cms:entry id="N12912" part="chapter3" ref="N12912" type="block">III - 3.6.2.</cms:entry><cms:entry id="N1291C" part="chapter3" ref="N1291C" type="citenumber">65</cms:entry><cms:entry id="N12926" part="chapter3" ref="N12926" type="mm">607#328</cms:entry><cms:entry id="I_Ref100671618" part="chapter3" ref="I_Ref100671618" type="link"/><cms:entry id="N12946" part="chapter3" ref="N12946" type="citenumber">66</cms:entry><cms:entry id="N12969" part="chapter3" ref="N12969" type="table"/><cms:entry id="I_Ref123483596" part="chapter3" ref="I_Ref123483596" type="link"/><cms:entry id="I_Ref87099314" part="chapter3" ref="I_Ref87099314" type="link"/><cms:entry id="N12C46" part="chapter3" ref="N12C46" type="section">III - 4.</cms:entry><cms:entry id="_Toc121401386" part="chapter3" ref="_Toc121401386" type="link"/><cms:entry id="_Toc143257633" part="chapter3" ref="_Toc143257633" type="link"/><cms:entry id="N12C53" part="chapter3" ref="N12C53" type="citenumber">67</cms:entry><cms:entry id="N12C90" part="chapter3" ref="N12C90" type="citenumber">68</cms:entry><cms:entry id="_Toc121401387" part="chapter3" ref="_Toc121401387" type="link"/><cms:entry id="N12CAD" part="chapter3" ref="N12CAD" type="subsection">III - 4.1.</cms:entry><cms:entry id="_Toc143257634" part="chapter3" ref="_Toc143257634" type="link"/><cms:entry id="N12CBA" part="chapter3" ref="N12CBA" type="citenumber">69</cms:entry><cms:entry id="N12CE4" part="chapter3" ref="N12CE4" type="citenumber">70</cms:entry><cms:entry id="N12D27" part="chapter3" ref="N12D27" type="citenumber">71</cms:entry><cms:entry id="_Toc121401388" part="chapter3" ref="_Toc121401388" type="link"/><cms:entry id="_Toc143257635" part="chapter3" ref="_Toc143257635" type="link"/><cms:entry id="N12D5D" part="chapter3" ref="N12D5D" type="subsection">III - 4.2.</cms:entry><cms:entry id="N12D6F" part="chapter3" ref="N12D6F" type="citenumber">72</cms:entry><cms:entry id="N12D86" part="chapter3" ref="N12D86" type="citenumber">73</cms:entry><cms:entry id="_Toc121401389" part="chapter3" ref="_Toc121401389" type="link"/><cms:entry id="_Toc143257636" part="chapter3" ref="_Toc143257636" type="link"/><cms:entry id="N12DB5" part="chapter3" ref="N12DB5" type="subsection">III - 4.3.</cms:entry><cms:entry id="N12DBC" part="chapter3" ref="N12DBC" type="citenumber">74</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">IV</cms:entry><cms:entry id="_Toc121401390" part="chapter4" ref="_Toc121401390" type="link"/><cms:entry id="_Toc143257637" part="chapter4" ref="_Toc143257637" type="link"/><cms:entry id="N12DD1" part="chapter4" ref="N12DD1" type="helpercitenumber">74</cms:entry><cms:entry id="_Toc121401391" part="chapter4" ref="_Toc121401391" type="link"/><cms:entry id="N12DD7" part="chapter4" ref="N12DD7" type="section">IV - 1.</cms:entry><cms:entry id="_Toc143257638" part="chapter4" ref="_Toc143257638" type="link"/><cms:entry id="N12DEC" part="chapter4" ref="N12DEC" type="citenumber">75</cms:entry><cms:entry id="_Toc121401392" part="chapter4" ref="_Toc121401392" type="link"/><cms:entry id="N12E20" part="chapter4" ref="N12E20" type="subsection">IV - 1.1.</cms:entry><cms:entry id="_Toc143257639" part="chapter4" ref="_Toc143257639" type="link"/><cms:entry id="N12E2A" part="chapter4" ref="N12E2A" type="citenumber">76</cms:entry><cms:entry id="_Toc121401393" part="chapter4" ref="_Toc121401393" type="link"/><cms:entry id="_Toc143257640" part="chapter4" ref="_Toc143257640" type="link"/><cms:entry id="N12E4D" part="chapter4" ref="N12E4D" type="subsection">IV - 1.2.</cms:entry><cms:entry id="N12E54" part="chapter4" ref="N12E54" type="citenumber">77</cms:entry><cms:entry id="N12E68" part="chapter4" ref="N12E68" type="citenumber">78</cms:entry><cms:entry id="N12E7C" part="chapter4" ref="N12E7C" type="citenumber">79</cms:entry><cms:entry id="N12E7F" part="chapter4" ref="N12E7F" type="table"/><cms:entry id="I_Ref123484513" part="chapter4" ref="I_Ref123484513" type="link"/><cms:entry id="_Toc121401394" part="chapter4" ref="_Toc121401394" type="link"/><cms:entry id="I_Ref121411509" part="chapter4" ref="I_Ref121411509" type="link"/><cms:entry id="I_Ref121760084" part="chapter4" ref="I_Ref121760084" type="link"/><cms:entry id="N12FE3" part="chapter4" ref="N12FE3" type="citenumber">80</cms:entry><cms:entry id="_Toc143257641" part="chapter4" ref="_Toc143257641" type="link"/><cms:entry id="N12FEE" part="chapter4" ref="N12FEE" type="subsection">IV - 1.3.</cms:entry><cms:entry id="N13009" part="chapter4" ref="N13009" type="citenumber">81</cms:entry><cms:entry id="N13060" part="chapter4" ref="N13060" type="citenumber">82</cms:entry><cms:entry id="N13088" part="chapter4" ref="N13088" type="citenumber">83</cms:entry><cms:entry id="_Toc143257642" part="chapter4" ref="_Toc143257642" type="link"/><cms:entry id="N130B0" part="chapter4" ref="N130B0" type="subsection">IV - 1.4.</cms:entry><cms:entry id="_Toc121401395" part="chapter4" ref="_Toc121401395" type="link"/><cms:entry id="_Toc143257643" part="chapter4" ref="_Toc143257643" type="link"/><cms:entry id="N130C6" part="chapter4" ref="N130C6" type="section">IV - 2.</cms:entry><cms:entry id="_Toc121401396" part="chapter4" ref="_Toc121401396" type="link"/><cms:entry id="N130D1" part="chapter4" ref="N130D1" type="subsection">IV - 2.1.</cms:entry><cms:entry id="_Toc143257644" part="chapter4" ref="_Toc143257644" type="link"/><cms:entry id="_Toc121401397" part="chapter4" ref="_Toc121401397" type="link"/><cms:entry id="_Toc143257645" part="chapter4" ref="_Toc143257645" type="link"/><cms:entry id="N130E9" part="chapter4" ref="N130E9" type="subsection">IV - 2.2.</cms:entry><cms:entry id="N130F0" part="chapter4" ref="N130F0" type="citenumber">84</cms:entry><cms:entry id="_Toc121401398" part="chapter4" ref="_Toc121401398" type="link"/><cms:entry id="_Toc143257646" part="chapter4" ref="_Toc143257646" type="link"/><cms:entry id="N13116" part="chapter4" ref="N13116" type="subsection">IV - 2.3.</cms:entry><cms:entry id="N1311D" part="chapter4" ref="N1311D" type="citenumber">85</cms:entry><cms:entry id="_Toc121401399" part="chapter4" ref="_Toc121401399" type="link"/><cms:entry id="_Toc143257647" part="chapter4" ref="_Toc143257647" type="link"/><cms:entry id="N13135" part="chapter4" ref="N13135" type="subsection">IV - 2.4.</cms:entry><cms:entry id="N1319A" part="chapter4" ref="N1319A" type="citenumber">86</cms:entry><cms:entry id="_Toc121401400" part="chapter4" ref="_Toc121401400" type="link"/><cms:entry id="_Toc143257648" part="chapter4" ref="_Toc143257648" type="link"/><cms:entry id="N131AB" part="chapter4" ref="N131AB" type="subsection">IV - 2.5.</cms:entry><cms:entry id="_Toc121401401" part="chapter4" ref="_Toc121401401" type="link"/><cms:entry id="_Toc143257649" part="chapter4" ref="_Toc143257649" type="link"/><cms:entry id="N131C3" part="chapter4" ref="N131C3" type="subsection">IV - 2.6.</cms:entry><cms:entry id="N131D0" part="chapter4" ref="N131D0" type="citenumber">87</cms:entry><cms:entry id="N131DF" part="chapter4" ref="N131DF" type="subsection">IV - 2.7.</cms:entry><cms:entry id="_Toc121401402" part="chapter4" ref="_Toc121401402" type="link"/><cms:entry id="_Toc143257650" part="chapter4" ref="_Toc143257650" type="link"/><cms:entry id="_Toc121401403" part="chapter4" ref="_Toc121401403" type="link"/><cms:entry id="_Toc143257651" part="chapter4" ref="_Toc143257651" type="link"/><cms:entry id="N131FD" part="chapter4" ref="N131FD" type="subsection">IV - 2.8.</cms:entry><cms:entry id="N13204" part="chapter4" ref="N13204" type="citenumber">88</cms:entry><cms:entry id="_Toc121401404" part="chapter4" ref="_Toc121401404" type="link"/><cms:entry id="_Toc143257652" part="chapter4" ref="_Toc143257652" type="link"/><cms:entry id="N13218" part="chapter4" ref="N13218" type="subsection">IV - 2.9.</cms:entry><cms:entry id="_Toc121401405" part="chapter4" ref="_Toc121401405" type="link"/><cms:entry id="_Toc143257653" part="chapter4" ref="_Toc143257653" type="link"/><cms:entry id="N13230" part="chapter4" ref="N13230" type="subsection">IV - 2.10.</cms:entry><cms:entry id="_Toc121401406" part="chapter4" ref="_Toc121401406" type="link"/><cms:entry id="_Toc143257654" part="chapter4" ref="_Toc143257654" type="link"/><cms:entry id="N1325C" part="chapter4" ref="N1325C" type="subsection">IV - 2.11.</cms:entry><cms:entry id="N13263" part="chapter4" ref="N13263" type="citenumber">89</cms:entry><cms:entry id="_Toc121401407" part="chapter4" ref="_Toc121401407" type="link"/><cms:entry id="_Toc143257655" part="chapter4" ref="_Toc143257655" type="link"/><cms:entry id="N1327C" part="chapter4" ref="N1327C" type="subsection">IV - 2.12.</cms:entry><cms:entry id="_Toc121401408" part="chapter4" ref="_Toc121401408" type="link"/><cms:entry id="_Toc143257656" part="chapter4" ref="_Toc143257656" type="link"/><cms:entry id="N13296" part="chapter4" ref="N13296" type="section">IV - 3.</cms:entry><cms:entry id="_Toc121401409" part="chapter4" ref="_Toc121401409" type="link"/><cms:entry id="N132A1" part="chapter4" ref="N132A1" type="subsection">IV - 3.1.</cms:entry><cms:entry id="_Toc143257657" part="chapter4" ref="_Toc143257657" type="link"/><cms:entry id="N132B6" part="chapter4" ref="N132B6" type="citenumber">90</cms:entry><cms:entry id="N132B9" part="chapter4" ref="N132B9" type="mm">604#517</cms:entry><cms:entry id="I_Ref85013377" part="chapter4" ref="I_Ref85013377" type="link"/><cms:entry id="N132D8" part="chapter4" ref="N132D8" type="table"/><cms:entry id="I_Ref123542375" part="chapter4" ref="I_Ref123542375" type="link"/><cms:entry id="N13486" part="chapter4" ref="N13486" type="citenumber">91</cms:entry><cms:entry id="N13493" part="chapter4" ref="N13493" type="mm">480#720</cms:entry><cms:entry id="I_Ref85031807" part="chapter4" ref="I_Ref85031807" type="link"/><cms:entry id="N134A6" part="chapter4" ref="N134A6" type="citenumber">92</cms:entry><cms:entry id="_Toc121401410" part="chapter4" ref="_Toc121401410" type="link"/><cms:entry id="_Toc143257658" part="chapter4" ref="_Toc143257658" type="link"/><cms:entry id="N134BE" part="chapter4" ref="N134BE" type="subsection">IV - 3.2.</cms:entry><cms:entry id="N134C3" part="chapter4" ref="N134C3" type="block">IV - 3.2.1.</cms:entry><cms:entry id="N134D1" part="chapter4" ref="N134D1" type="citenumber">93</cms:entry><cms:entry id="N134D4" part="chapter4" ref="N134D4" type="mm">607#249</cms:entry><cms:entry id="I_Ref85038390" part="chapter4" ref="I_Ref85038390" type="link"/><cms:entry id="N134F3" part="chapter4" ref="N134F3" type="block">IV - 3.2.2.</cms:entry><cms:entry id="I_Ref123546015" part="chapter4" ref="I_Ref123546015" type="link"/><cms:entry id="N13507" part="chapter4" ref="N13507" type="citenumber">94</cms:entry><cms:entry id="N1350A" part="chapter4" ref="N1350A" type="table"/><cms:entry id="I_Ref123559118" part="chapter4" ref="I_Ref123559118" type="link"/><cms:entry id="N13AC5" part="chapter4" ref="N13AC5" type="block">IV - 3.2.3.</cms:entry><cms:entry id="N13ACF" part="chapter4" ref="N13ACF" type="citenumber">95</cms:entry><cms:entry id="N13AF2" part="chapter4" ref="N13AF2" type="table"/><cms:entry id="I_Ref124093536" part="chapter4" ref="I_Ref124093536" type="link"/><cms:entry id="N13B32" part="chapter4" ref="N13B32" type="mm">593#358</cms:entry><cms:entry id="N13B42" part="chapter4" ref="N13B42" type="mm">593#367</cms:entry><cms:entry id="N13B4F" part="chapter4" ref="N13B4F" type="citenumber">96</cms:entry><cms:entry id="_Toc121401411" part="chapter4" ref="_Toc121401411" type="link"/><cms:entry id="_Toc143257659" part="chapter4" ref="_Toc143257659" type="link"/><cms:entry id="N13B64" part="chapter4" ref="N13B64" type="subsection">IV - 3.3.</cms:entry><cms:entry id="N13B6C" part="chapter4" ref="N13B6C" type="block">IV - 3.3.1.</cms:entry><cms:entry id="N13B7E" part="chapter4" ref="N13B7E" type="citenumber">97</cms:entry><cms:entry id="N13B87" part="chapter4" ref="N13B87" type="mm">605#423</cms:entry><cms:entry id="I_Ref106647071" part="chapter4" ref="I_Ref106647071" type="link"/><cms:entry id="I_Ref106647614" part="chapter4" ref="I_Ref106647614" type="link"/><cms:entry id="N13BA5" part="chapter4" ref="N13BA5" type="block">IV - 3.3.2.</cms:entry><cms:entry id="N13BAC" part="chapter4" ref="N13BAC" type="citenumber">98</cms:entry><cms:entry id="N13BC0" part="chapter4" ref="N13BC0" type="mm">604#216</cms:entry><cms:entry id="I_Ref123485577" part="chapter4" ref="I_Ref123485577" type="link"/><cms:entry id="N13BD4" part="chapter4" ref="N13BD4" type="block">IV - 3.3.3.</cms:entry><cms:entry id="N13BDB" part="chapter4" ref="N13BDB" type="citenumber">99</cms:entry><cms:entry id="N13BEE" part="chapter4" ref="N13BEE" type="mm">605#265</cms:entry><cms:entry id="I_Ref106642492" part="chapter4" ref="I_Ref106642492" type="link"/><cms:entry id="_Toc121401412" part="chapter4" ref="_Toc121401412" type="link"/><cms:entry id="_Toc143257660" part="chapter4" ref="_Toc143257660" type="link"/><cms:entry id="N13C08" part="chapter4" ref="N13C08" type="subsection">IV - 3.4.</cms:entry><cms:entry id="N13C0F" part="chapter4" ref="N13C0F" type="citenumber">100</cms:entry><cms:entry id="N13C19" part="chapter4" ref="N13C19" type="mm">595#305</cms:entry><cms:entry id="I_Ref85112517" part="chapter4" ref="I_Ref85112517" type="link"/><cms:entry id="_Toc121401413" part="chapter4" ref="_Toc121401413" type="link"/><cms:entry id="_Toc143257661" part="chapter4" ref="_Toc143257661" type="link"/><cms:entry id="N13C35" part="chapter4" ref="N13C35" type="subsection">IV - 3.5.</cms:entry><cms:entry id="N13C3F" part="chapter4" ref="N13C3F" type="citenumber">101</cms:entry><cms:entry id="N13C42" part="chapter4" ref="N13C42" type="mm">604#500</cms:entry><cms:entry id="_Toc121401414" part="chapter4" ref="_Toc121401414" type="link"/><cms:entry id="_Toc143257662" part="chapter4" ref="_Toc143257662" type="link"/><cms:entry id="N13C63" part="chapter4" ref="N13C63" type="subsection">IV - 3.6.</cms:entry><cms:entry id="N13C78" part="chapter4" ref="N13C78" type="citenumber">102</cms:entry><cms:entry id="N13C7B" part="chapter4" ref="N13C7B" type="mm">605#265</cms:entry><cms:entry id="I_Ref114211818" part="chapter4" ref="I_Ref114211818" type="link"/><cms:entry id="_Toc121401415" part="chapter4" ref="_Toc121401415" type="link"/><cms:entry id="_Toc143257663" part="chapter4" ref="_Toc143257663" type="link"/><cms:entry id="N13C99" part="chapter4" ref="N13C99" type="subsection">IV - 3.7.</cms:entry><cms:entry id="N13C9E" part="chapter4" ref="N13C9E" type="block">IV - 3.7.1.</cms:entry><cms:entry id="N13CA7" part="chapter4" ref="N13CA7" type="block">IV - 3.7.2.</cms:entry><cms:entry id="N13CAE" part="chapter4" ref="N13CAE" type="mm">604#392</cms:entry><cms:entry id="I_Ref107674307" part="chapter4" ref="I_Ref107674307" type="link"/><cms:entry id="N13CC3" part="chapter4" ref="N13CC3" type="citenumber">103</cms:entry><cms:entry id="_Toc121401416" part="chapter4" ref="_Toc121401416" type="link"/><cms:entry id="_Toc143257664" part="chapter4" ref="_Toc143257664" type="link"/><cms:entry id="N13CDD" part="chapter4" ref="N13CDD" type="subsection">IV - 3.8.</cms:entry><cms:entry id="N13CF6" part="chapter4" ref="N13CF6" type="block">IV - 3.8.1.</cms:entry><cms:entry id="N13D0A" part="chapter4" ref="N13D0A" type="citenumber">104</cms:entry><cms:entry id="N13D16" part="chapter4" ref="N13D16" type="block">IV - 3.8.2.</cms:entry><cms:entry id="N13D35" part="chapter4" ref="N13D35" type="mm">607#230</cms:entry><cms:entry id="I_Ref98942997" part="chapter4" ref="I_Ref98942997" type="link"/><cms:entry id="N13D43" part="chapter4" ref="N13D43" type="citenumber">105</cms:entry><cms:entry id="N13F14" part="chapter4" ref="N13F14" type="citenumber">106</cms:entry><cms:entry id="N14811" part="chapter4" ref="N14811" type="section">IV - 4.</cms:entry><cms:entry id="_Toc121401417" part="chapter4" ref="_Toc121401417" type="link"/><cms:entry id="_Toc143257665" part="chapter4" ref="_Toc143257665" type="link"/><cms:entry id="_Toc121401418" part="chapter4" ref="_Toc121401418" type="link"/><cms:entry id="N1482C" part="chapter4" ref="N1482C" type="subsection">IV - 4.1.</cms:entry><cms:entry id="_Toc143257666" part="chapter4" ref="_Toc143257666" type="link"/><cms:entry id="N14836" part="chapter4" ref="N14836" type="citenumber">107</cms:entry><cms:entry id="_Toc121401419" part="chapter4" ref="_Toc121401419" type="link"/><cms:entry id="_Toc143257667" part="chapter4" ref="_Toc143257667" type="link"/><cms:entry id="N14856" part="chapter4" ref="N14856" type="subsection">IV - 4.2.</cms:entry><cms:entry id="N14863" part="chapter4" ref="N14863" type="citenumber">108</cms:entry><cms:entry id="N1487B" part="chapter4" ref="N1487B" type="citenumber">109</cms:entry><cms:entry id="_Toc121401420" part="chapter4" ref="_Toc121401420" type="link"/><cms:entry id="_Toc143257668" part="chapter4" ref="_Toc143257668" type="link"/><cms:entry id="N1488F" part="chapter4" ref="N1488F" type="subsection">IV - 4.3.</cms:entry><cms:entry id="N1489C" part="chapter4" ref="N1489C" type="citenumber">110</cms:entry><cms:entry id="_Toc121401421" part="chapter4" ref="_Toc121401421" type="link"/><cms:entry id="_Toc143257669" part="chapter4" ref="_Toc143257669" type="link"/><cms:entry id="N148B3" part="chapter4" ref="N148B3" type="subsection">IV - 4.4.</cms:entry><cms:entry id="N148C6" part="chapter4" ref="N148C6" type="citenumber">111</cms:entry><cms:entry id="_Toc121401422" part="chapter4" ref="_Toc121401422" type="link"/><cms:entry id="_Toc143257670" part="chapter4" ref="_Toc143257670" type="link"/><cms:entry id="N148E3" part="chapter4" ref="N148E3" type="subsection">IV - 4.5.</cms:entry><cms:entry id="N148F1" part="chapter4" ref="N148F1" type="citenumber">112</cms:entry><cms:entry id="_Toc121401423" part="chapter4" ref="_Toc121401423" type="link"/><cms:entry id="_Toc143257671" part="chapter4" ref="_Toc143257671" type="link"/><cms:entry id="N1490B" part="chapter4" ref="N1490B" type="subsection">IV - 4.6.</cms:entry><cms:entry id="N1491F" part="chapter4" ref="N1491F" type="citenumber">113</cms:entry><cms:entry id="_Toc121401424" part="chapter4" ref="_Toc121401424" type="link"/><cms:entry id="_Toc143257672" part="chapter4" ref="_Toc143257672" type="link"/><cms:entry id="N14930" part="chapter4" ref="N14930" type="subsection">IV - 4.7.</cms:entry><cms:entry id="N1493D" part="chapter4" ref="N1493D" type="citenumber">114</cms:entry><cms:entry id="N14965" part="chapter4" ref="N14965" type="citenumber">115</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">V</cms:entry><cms:entry id="_Toc121401425" part="chapter5" ref="_Toc121401425" type="link"/><cms:entry id="_Toc143257673" part="chapter5" ref="_Toc143257673" type="link"/><cms:entry id="N14997" part="chapter5" ref="N14997" type="citenumber">116</cms:entry><cms:entry id="N149A7" part="chapter5" ref="N149A7" type="citenumber">117</cms:entry><cms:entry id="N149CF" part="chapter5" ref="N149CF" type="citenumber">118</cms:entry><cms:entry id="N149F9" part="chapter5" ref="N149F9" type="citenumber">119</cms:entry><cms:entry id="chapter6" part="chapter6" ref="chapter6" type="chapter">VI</cms:entry><cms:entry id="_Toc143257674" part="chapter6" ref="_Toc143257674" type="link"/><cms:entry id="N14A10" part="chapter6" ref="N14A10" type="helpercitenumber">119</cms:entry><cms:entry id="N14A18" part="chapter6" ref="N14A18" type="citenumber">120</cms:entry><cms:entry id="N14B11" part="chapter6" ref="N14B11" type="citenumber">121</cms:entry><cms:entry ref="N14B5C" type="back"/><cms:entry ref="N14B5E" type="bibliography">Literaturverzeichnis</cms:entry><cms:entry ref="_Toc143257677" type="link"/><cms:entry ref="_bib213" type="citation"/><cms:entry ref="_bib270" type="citation"/><cms:entry ref="_bib187" type="citation"/><cms:entry ref="_bib61" type="citation"/><cms:entry ref="_bib126" type="citation"/><cms:entry ref="_bib69" type="citation"/><cms:entry ref="_bib367" type="citation"/><cms:entry ref="_bib243" type="citation"/><cms:entry ref="_bib341" type="citation"/><cms:entry ref="_bib392" type="citation"/><cms:entry ref="_bib234" type="citation"/><cms:entry ref="_bib272" type="citation"/><cms:entry ref="_bib295" type="citation"/><cms:entry ref="_bib190" type="citation"/><cms:entry ref="_bib312" type="citation"/><cms:entry ref="_bib339" type="citation"/><cms:entry ref="_bib355" type="citation"/><cms:entry ref="_bib349" type="citation"/><cms:entry ref="_bib282" type="citation"/><cms:entry ref="_bib141" type="citation"/><cms:entry ref="_bib316" type="citation"/><cms:entry ref="_bib39" type="citation"/><cms:entry ref="_bib360" type="citation"/><cms:entry ref="_bib71" type="citation"/><cms:entry ref="_bib214" type="citation"/><cms:entry ref="_bib432" type="citation"/><cms:entry ref="_bib309" type="citation"/><cms:entry ref="_bib336" type="citation"/><cms:entry ref="_bib79" type="citation"/><cms:entry ref="_bib105" type="citation"/><cms:entry ref="_bib405" type="citation"/><cms:entry ref="_bib373" type="citation"/><cms:entry ref="_bib129" type="citation"/><cms:entry ref="_bib245" type="citation"/><cms:entry ref="_bib366" type="citation"/><cms:entry ref="_bib370" type="citation"/><cms:entry ref="_bib174" type="citation"/><cms:entry ref="_bib70" type="citation"/><cms:entry ref="_bib233" type="citation"/><cms:entry ref="_bib283" type="citation"/><cms:entry ref="_bib122" type="citation"/><cms:entry ref="_bib198" type="citation"/><cms:entry ref="_bib249" type="citation"/><cms:entry ref="_bib343" type="citation"/><cms:entry ref="_bib409" type="citation"/><cms:entry ref="_bib210" type="citation"/><cms:entry ref="_bib381" type="citation"/><cms:entry ref="_bib364" type="citation"/><cms:entry ref="_bib207" type="citation"/><cms:entry ref="_bib434" type="citation"/><cms:entry ref="_bib36" type="citation"/><cms:entry ref="_bib218" type="citation"/><cms:entry ref="_bib56" type="citation"/><cms:entry ref="_bib68" type="citation"/><cms:entry ref="_bib9" type="citation"/><cms:entry ref="_bib238" type="citation"/><cms:entry ref="_bib28" type="citation"/><cms:entry ref="_bib231" type="citation"/><cms:entry ref="_bib281" type="citation"/><cms:entry ref="_bib319" type="citation"/><cms:entry ref="_bib3" type="citation"/><cms:entry ref="_bib47" type="citation"/><cms:entry ref="_bib358" type="citation"/><cms:entry ref="_bib326" type="citation"/><cms:entry ref="_bib325" type="citation"/><cms:entry ref="_bib408" type="citation"/><cms:entry ref="_bib344" type="citation"/><cms:entry ref="_bib93" type="citation"/><cms:entry ref="_bib112" type="citation"/><cms:entry ref="_bib375" type="citation"/><cms:entry ref="_bib345" type="citation"/><cms:entry ref="_bib338" type="citation"/><cms:entry ref="_bib67" type="citation"/><cms:entry ref="_bib191" type="citation"/><cms:entry ref="_bib237" type="citation"/><cms:entry ref="_bib50" type="citation"/><cms:entry ref="_bib212" type="citation"/><cms:entry ref="_bib75" type="citation"/><cms:entry ref="_bib41" type="citation"/><cms:entry ref="_bib268" type="citation"/><cms:entry ref="_bib369" type="citation"/><cms:entry ref="_bib101" type="citation"/><cms:entry ref="_bib100" type="citation"/><cms:entry ref="_bib99" type="citation"/><cms:entry ref="_bib429" type="citation"/><cms:entry ref="_bib31" type="citation"/><cms:entry ref="_bib261" type="citation"/><cms:entry ref="_bib116" type="citation"/><cms:entry ref="_bib350" type="citation"/><cms:entry ref="_bib64" type="citation"/><cms:entry ref="_bib196" type="citation"/><cms:entry ref="_bib250" type="citation"/><cms:entry ref="_bib194" type="citation"/><cms:entry ref="_bib428" type="citation"/><cms:entry ref="_bib354" type="citation"/><cms:entry ref="_bib217" type="citation"/><cms:entry ref="_bib192" type="citation"/><cms:entry ref="_bib188" type="citation"/><cms:entry ref="_bib184" type="citation"/><cms:entry ref="_bib301" type="citation"/><cms:entry ref="_bib263" type="citation"/><cms:entry ref="_bib30" type="citation"/><cms:entry ref="_bib199" type="citation"/><cms:entry ref="_bib277" type="citation"/><cms:entry ref="_bib65" type="citation"/><cms:entry ref="_bib205" type="citation"/><cms:entry ref="_bib300" type="citation"/><cms:entry ref="_bib228" type="citation"/><cms:entry ref="_bib229" type="citation"/><cms:entry ref="_bib197" type="citation"/><cms:entry ref="_bib49" type="citation"/><cms:entry ref="_bib284" type="citation"/><cms:entry ref="_bib106" type="citation"/><cms:entry ref="_bib4" type="citation"/><cms:entry ref="_bib253" type="citation"/><cms:entry ref="_bib16" type="citation"/><cms:entry ref="_bib280" type="citation"/><cms:entry ref="_bib298" type="citation"/><cms:entry ref="_bib421" type="citation"/><cms:entry ref="_bib420" type="citation"/><cms:entry ref="_bib19" type="citation"/><cms:entry ref="_bib396" type="citation"/><cms:entry ref="_bib308" type="citation"/><cms:entry ref="_bib169" type="citation"/><cms:entry ref="_bib95" type="citation"/><cms:entry ref="_bib185" type="citation"/><cms:entry ref="_bib410" type="citation"/><cms:entry ref="_bib223" type="citation"/><cms:entry ref="_bib208" type="citation"/><cms:entry ref="_bib431" type="citation"/><cms:entry ref="_bib239" type="citation"/><cms:entry ref="_bib365" type="citation"/><cms:entry ref="_bib220" type="citation"/><cms:entry ref="_bib435" type="citation"/><cms:entry ref="_bib386" type="citation"/><cms:entry ref="_bib254" type="citation"/><cms:entry ref="_bib359" type="citation"/><cms:entry ref="_bib347" type="citation"/><cms:entry ref="_bib132" type="citation"/><cms:entry ref="_bib74" type="citation"/><cms:entry ref="_bib378" type="citation"/><cms:entry ref="_bib82" type="citation"/><cms:entry ref="_bib119" type="citation"/><cms:entry ref="_bib331" type="citation"/><cms:entry ref="_bib255" type="citation"/><cms:entry ref="_bib411" type="citation"/><cms:entry ref="_bib286" type="citation"/><cms:entry ref="_bib356" type="citation"/><cms:entry ref="_bib48" type="citation"/><cms:entry ref="_bib40" type="citation"/><cms:entry ref="_bib256" type="citation"/><cms:entry ref="_bib287" type="citation"/><cms:entry ref="_bib404" type="citation"/><cms:entry ref="_bib385" type="citation"/><cms:entry ref="_bib304" type="citation"/><cms:entry ref="_bib403" type="citation"/><cms:entry ref="_bib348" type="citation"/><cms:entry ref="_bib305" type="citation"/><cms:entry ref="_bib332" type="citation"/><cms:entry ref="_bib152" type="citation"/><cms:entry ref="_bib257" type="citation"/><cms:entry ref="_bib221" type="citation"/><cms:entry ref="_bib87" type="citation"/><cms:entry ref="_bib288" type="citation"/><cms:entry ref="_bib294" type="citation"/><cms:entry ref="_bib401" type="citation"/><cms:entry ref="_bib426" type="citation"/><cms:entry ref="_bib130" type="citation"/><cms:entry ref="_bib306" type="citation"/><cms:entry ref="_bib379" type="citation"/><cms:entry ref="_bib337" type="citation"/><cms:entry ref="_bib183" type="citation"/><cms:entry ref="_bib377" type="citation"/><cms:entry ref="_bib107" type="citation"/><cms:entry ref="_bib108" type="citation"/><cms:entry ref="_bib111" type="citation"/><cms:entry ref="_bib109" type="citation"/><cms:entry ref="_bib374" type="citation"/><cms:entry ref="_bib258" type="citation"/><cms:entry ref="_bib103" type="citation"/><cms:entry ref="_bib120" type="citation"/><cms:entry ref="_bib23" type="citation"/><cms:entry ref="_bib10" type="citation"/><cms:entry ref="_bib216" type="citation"/><cms:entry ref="_bib398" type="citation"/><cms:entry ref="_bib290" type="citation"/><cms:entry ref="_bib189" type="citation"/><cms:entry ref="_bib380" type="citation"/><cms:entry ref="_bib202" type="citation"/><cms:entry ref="_bib333" type="citation"/><cms:entry ref="_bib335" type="citation"/><cms:entry ref="_bib13" type="citation"/><cms:entry ref="_bib232" type="citation"/><cms:entry ref="_bib311" type="citation"/><cms:entry ref="_bib418" type="citation"/><cms:entry ref="_bib215" type="citation"/><cms:entry ref="_bib391" type="citation"/><cms:entry ref="_bib310" type="citation"/><cms:entry ref="_bib236" type="citation"/><cms:entry ref="_bib289" type="citation"/><cms:entry ref="_bib58" type="citation"/><cms:entry ref="_bib81" type="citation"/><cms:entry ref="_bib27" type="citation"/><cms:entry ref="_bib297" type="citation"/><cms:entry ref="_bib419" type="citation"/><cms:entry ref="_bib32" type="citation"/><cms:entry ref="_bib433" type="citation"/><cms:entry ref="_bib12" type="citation"/><cms:entry ref="_bib121" type="citation"/><cms:entry ref="_bib219" type="citation"/><cms:entry ref="_bib8" type="citation"/><cms:entry ref="_bib193" type="citation"/><cms:entry ref="_bib278" type="citation"/><cms:entry ref="_bib73" type="citation"/><cms:entry ref="_bib97" type="citation"/><cms:entry ref="_bib96" type="citation"/><cms:entry ref="_bib54" type="citation"/><cms:entry ref="_bib240" type="citation"/><cms:entry ref="_bib376" type="citation"/><cms:entry id="N16399" part="N16399" ref="N16399" type="abbreviation">Abkürzungsverzeichnis (Auswahl)</cms:entry><cms:entry id="N163A0" part="N16399" ref="N163A0" type="table"/><cms:entry id="N165CF" part="N165CF" ref="N165CF" type="acknowledgement">
            Danksagung</cms:entry><cms:entry id="_Toc143257678" part="N165CF" ref="_Toc143257678" type="link"/><cms:entry id="N165EA" part="N165EA" ref="N165EA" type="appendix">
            Publikationen </cms:entry><cms:entry id="N165EC" part="N165EA" ref="N165EC" type="head"/><cms:entry id="_Toc143257679" part="N165EA" ref="_Toc143257679" type="link"/><cms:entry id="N165F2" part="N165EA" ref="N165F2" type="p"/><cms:entry id="N165FB" part="N165EA" ref="N165FB" type="p"/><cms:entry id="N16601" part="N165EA" ref="N16601" type="p"/><cms:entry id="N16607" part="N165EA" ref="N16607" type="p"/><cms:entry id="N1660D" part="N165EA" ref="N1660D" type="p"/><cms:entry id="N16613" part="N165EA" ref="N16613" type="p"/><cms:entry id="N16619" part="N165EA" ref="N16619" type="p"/><cms:entry id="N1661F" part="N165EA" ref="N1661F" type="p"/><cms:entry id="N16628" part="N165EA" ref="N16628" type="p"/><cms:entry id="N1662E" part="N165EA" ref="N1662E" type="p"/><cms:entry id="N16634" part="N165EA" ref="N16634" type="p"/><cms:entry id="N1663A" part="N165EA" ref="N1663A" type="p"/><cms:entry id="N16640" part="N165EA" ref="N16640" type="p"/><cms:entry id="N16649" part="N165EA" ref="N16649" type="p"/><cms:entry id="N1664F" part="N165EA" ref="N1664F" type="p"/><cms:entry id="N16658" part="N165EA" ref="N16658" type="p"/><cms:entry id="N1665E" part="N165EA" ref="N1665E" type="p"/><cms:entry id="N16664" part="N165EA" ref="N16664" type="p"/><cms:entry id="N1666A" part="N165EA" ref="N1666A" type="p"/><cms:entry id="N16670" part="N165EA" ref="N16670" type="p"/><cms:entry id="N16676" part="N165EA" ref="N16676" type="p"/><cms:entry id="N1667C" part="N165EA" ref="N1667C" type="p"/><cms:entry id="N16683" part="N16683" ref="N16683" type="vita">
            Lebenslauf</cms:entry><cms:entry id="_Toc143257680" part="N16683" ref="_Toc143257680" type="link"/><cms:entry id="N1668D" part="N16683" ref="N1668D" type="table"/><cms:entry id="N168E2" part="N168E2" ref="N168E2" type="declaration">
            Selbstständigkeitserklärung</cms:entry><cms:entry id="_Toc143257681" part="N168E2" ref="_Toc143257681" type="link"/><cms:entry part="N14B5E" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N14B5E">
         <head>Literaturverzeichnis</head>
         <p>
            <link id="_Toc143257677"/>
         </p>
         <p>
         <citation id="_bib213" published="yes" workType="Journal"><workauthor>Ahima, R. S. und Flier, J. S.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Adipose tissue as an endocrine organ</articletitle>, <worktitle>Trends Endocrinol Metab</worktitle> <volume>11</volume> [<number>8</number>], Seite <pages>327</pages>-<pages>332</pages>. </citation>
<citation id="_bib270" published="yes" workType="Journal"><workauthor>Albiston, A. L.; McDowall, S. G.; Matsacos, D.; Sim, P.; Clune, E.; Mustafa, T.; Lee, J.; Mendelsohn, F. A.; Simpson, R. J.; Connolly, L. M. und Chai, S. Y.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>276</volume> [<number>52</number>], Seite <pages>48623</pages>-<pages>48626</pages>. </citation>
<citation id="_bib187" published="yes" workType="Journal"><workauthor>Allison, D. B.; Fontaine, K. R.; Manson, J. E.; Stevens, J. und VanItallie, T. B.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Annual deaths attributable to obesity in the United States</articletitle>, <worktitle>JAMA</worktitle> <volume>282</volume> [<number>16</number>], Seite <pages>1530</pages>-<pages>1538</pages>. </citation>
<citation id="_bib61" published="yes" workType="Journal"><workauthor>Alzheimer, Alois</workauthor> (<pubdate>1906</pubdate>): <articletitle>Über eine eigenartige Erkrankung der Hirnrinde</articletitle>, <worktitle>Zentralblatt für Nervenheilkunde und Psychiatrie</worktitle> <volume>30</volume>, Seite <pages>177</pages>-<pages>179</pages>. </citation>
<citation id="_bib126" published="yes" workType="Journal"><workauthor>Arnal, J. F.; Castano, C.; Maupas, E.; Mugniot, A.; Darblade, B.; Gourdy, P.; Michel, J. B. und Bayard, F.</workauthor> (<pubdate>2001b</pubdate>): <articletitle>Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice</articletitle>, <worktitle>Atherosclerosis</worktitle> <volume>155</volume> [<number>2</number>], Seite <pages>291</pages>-<pages>295</pages>. </citation>
<citation id="_bib69" published="yes" workType="Journal"><workauthor>Atwood, C. S.; Moir, R. D.; Huang, X.; Scarpa, R. C.; Bacarra, N. M.; Romano, D. M.; Hartshorn, M. A.; Tanzi, R. E. und Bush, A. I.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>273</volume> [<number>21</number>], Seite <pages>12817</pages>-<pages>12826</pages>. </citation>
<citation id="_bib367" published="yes" workType="Journal"><workauthor>Aust, L; Dongowski, G; Frenz, U; Täufel, A und Noack, R</workauthor> (<pubdate>2001</pubdate>): <articletitle>Estimation of available energy of dietary fibres by indirect calorimetry in rats</articletitle>, <worktitle>Eur.J Nutr.</worktitle> <volume>40</volume>, Seite <pages>23</pages>-<pages>29</pages>. </citation>
<citation id="_bib243" published="yes" workType="Journal"><workauthor>Backstrom, J. R.; Lim, G. P.; Cullen, M. J. und Tokes, Z. A.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40)</articletitle>, <worktitle>J Neurosci.</worktitle> <volume>16</volume> [<number>24</number>], Seite <pages>7910</pages>-<pages>7919</pages>. </citation>
<citation id="_bib341" published="yes" workType="Journal"><workauthor>Bado, A.; Roze, C.; Lewin, M. J. und Dubrasquet, M.</workauthor> (<pubdate>1989</pubdate>): <articletitle>Endogenous opioid peptides in the control of food intake in cats</articletitle>, <worktitle>Peptides</worktitle> <volume>10</volume> [<number>5</number>], Seite <pages>967</pages>-<pages>971</pages>. </citation>
<citation id="_bib392" published="yes" workType="Journal"><workauthor>Bae, S. J.; Matsunaga, Y.; Takenaka, M.; Tanaka, Y.; Hamazaki, Y.; Shimizu, K. und Katayama, I.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts</articletitle>, <worktitle>Int.Arch.Allergy Immunol.</worktitle> <volume>127</volume> [<number>4</number>], Seite <pages>316</pages>-<pages>321</pages>. </citation>
<citation id="_bib234" published="yes" workType="Journal"><workauthor>Barker, P. E.; Shipp, M. A.; D'Adamio, L.; Masteller, E. L. und Reinherz, E. L.</workauthor> (<pubdate>1989</pubdate>): <articletitle>The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27)</articletitle>, <worktitle>J Immunol.</worktitle> <volume>142</volume> [<number>1</number>], Seite <pages>283</pages>-<pages>287</pages>. </citation>
<citation id="_bib272" published="yes" workType="Journal"><workauthor>Barnes, K.; Matsas, R.; Hooper, N. M.; Turner, A. J. und Kenny, A. J.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Endopeptidase-24.11 is striosomally ordered in pig brain and, in contrast to aminopeptidase N and peptidyl dipeptidase A ('angiotensin converting enzyme'), is a marker for a set of striatal efferent fibres</articletitle>, <worktitle>Neuroscience</worktitle> <volume>27</volume> [<number>3</number>], Seite <pages>799</pages>-<pages>817</pages>. </citation>
<citation id="_bib295" published="yes" workType="Journal"><workauthor>Barnes, K.; Turner, A. J. und Kenny, A. J.</workauthor> (<pubdate>1993</pubdate>): <articletitle>An immunoelectron microscopic study of pig substantia nigra shows co-localization of endopeptidase-24.11 with substance P</articletitle>, <worktitle>Neuroscience</worktitle> <volume>53</volume> [<number>4</number>], Seite <pages>1073</pages>-<pages>1082</pages>. </citation>
<citation id="_bib190" published="yes" workType="Journal"><workauthor>Barsh, G. S.; Farooqi, I. S. und O'Rahilly, S.</workauthor> (<pubdate>2000a</pubdate>): <articletitle>Genetics of body-weight regulation</articletitle>, <worktitle>Nature</worktitle> <volume>404</volume> [<number>6778</number>], Seite <pages>644</pages>-<pages>651</pages>. </citation>
<citation id="_bib312" published="yes" workType="Journal"><workauthor>Beliaev, N. A.; Brusov, O. S. und Panchenko, L. F.</workauthor> (<pubdate>1983b</pubdate>): <articletitle>[Effect of chronic alcohol consumption on activity of enkephalinase A in rat striatum, hypothalamus and midbrain]</articletitle>, <worktitle>Vopr.Med.Khim.</worktitle> <volume>29</volume> [<number>1</number>], Seite <pages>102</pages>-<pages>107</pages>. URL: <url href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Citation&amp;list_uids=6340337" type="URL">PM:6340337</url> </citation>
<citation id="_bib339" published="yes" workType="Journal"><workauthor>Bergmann, KE und Mensink, GB</workauthor> (<pubdate>1999</pubdate>): <articletitle>Körpermaße und Übergewicht</articletitle>, <worktitle>Gesundheitswesen</worktitle> <volume>61</volume>, Seite <pages>S115</pages>-<pages>S120</pages>. </citation>
<citation id="_bib355" published="yes" workType="Journal"><workauthor>Berman, Yemiliya; Mzhavia, Nino; Polonskaia, Ann und Devi, Lakshmi A.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Impaired Prohormone Convertases in Cpefat/Cpefat Mice</articletitle>, <worktitle>Journal of Biological Chemistry</worktitle> <volume>276</volume> [<number>2</number>], Seite <pages>1466</pages>-<pages>1473</pages>. </citation>
<citation id="_bib349" published="yes" workType="Journal"><workauthor>Beyreuther, Konrad</workauthor> (<pubdate>1999</pubdate>): <articletitle>Alzheimersche Krankheit - Molekulares Verständnis und therapeutische Implikationen</articletitle>, <url href="http://www.fes.de/fulltext/asfo/00234toc.htm" type="URL">http://www.fes.de/fulltext/asfo/00234toc.htm</url>. </citation>
<citation id="_bib282" published="yes" workType="Journal"><workauthor>Bitan, G.; Kirkitadze, M. D.; Lomakin, A.; Vollers, S. S.; Benedek, G. B. und Teplow, D. B.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>100</volume> [<number>1</number>], Seite <pages>330</pages>-<pages>335</pages>. </citation>
<citation id="_bib141" published="yes" workType="Journal"><workauthor>Bitan, Gal; Kirkitadze, Marina D.; Lomakin, Aleksey; Vollers, Sabrina S.; Benedek, George B. und Teplow, David B.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Amyloid beta -protein (Abeta ) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways</articletitle>, <worktitle>Proceedings of the National Academy of Sciences</worktitle> <volume>100</volume> [<number>1</number>], Seite <pages>330</pages>-<pages>335</pages>. </citation>
<citation id="_bib316" published="yes" workType="Journal"><workauthor>Blum, K.; Trachtenberg, M. C.; Elliott, C. E.; Dingler, M. L.; Sexton, R. L.; Samuels, A. I. und Cataldie, L.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Enkephalinase inhibition and precursor amino acid loading improves inpatient treatment of alcohol and polydrug abusers: double-blind placebo-controlled study of the nutritional adjunct SAAVE</articletitle>, <worktitle>Alcohol</worktitle> <volume>5</volume> [<number>6</number>], Seite <pages>481</pages>-<pages>493</pages>. </citation>
<citation id="_bib39" published="yes" workType="Journal"><workauthor>Bradford, M. M.</workauthor> (<pubdate>1976</pubdate>): <articletitle>A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding</articletitle>, <worktitle>Anal.Biochem</worktitle> <volume>72</volume>, Seite <pages>248</pages>-<pages>254</pages>. </citation>
<citation id="_bib360" published="yes" workType="Journal"><workauthor>Brady, K. T. und Sonne, S. C.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The role of stress in alcohol use, alcoholism treatment, and relapse</articletitle>, <worktitle>Alcohol Res.Health</worktitle> <volume>23</volume> [<number>4</number>], Seite <pages>263</pages>-<pages>271</pages>. </citation>
<citation id="_bib71" published="yes" workType="Journal"><workauthor>Brzyska, M.; Bacia, A. und Elbaum, D.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Oxidative and hydrolytic properties of beta-amyloid</articletitle>, <worktitle>Eur.J Biochem</worktitle> <volume>268</volume> [<number>12</number>], Seite <pages>3443</pages>-<pages>3454</pages>. </citation>
<citation id="_bib214" published="yes" workType="Journal"><workauthor>Bucciantini, M.; Giannoni, E.; Chiti, F.; Baroni, F.; Formigli, L.; Zurdo, J.; Taddei, N.; Ramponi, G.; Dobson, C. M. und Stefani, M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases</articletitle>, <worktitle>Nature</worktitle> <volume>416</volume> [<number>6880</number>], Seite <pages>507</pages>-<pages>511</pages>. </citation>
<citation id="_bib432" published="yes" workType="Journal"><workauthor>Buenger, L.; Herrendoerfer, G. und Renne, U.</workauthor> (<pubdate>1990</pubdate>): <articletitle>Results of long term-selection for growth traits in laboratory mice.</articletitle>, <worktitle>Proceedings of the 4th World Congress on Genetics Applied to Livestock Production</worktitle> <volume>13</volume>, Seite <pages>321</pages>-<pages>324</pages>. </citation>
<citation id="_bib309" published="yes" workType="Journal"><workauthor>Bundesministerium für Gesundheit und Soziale Sicherung</workauthor> (<pubdate>2000</pubdate>): <articletitle>Alkoholkonsum und alkoholbezogene Störungen in Deutschland</articletitle>, <worktitle>Schriftenreihe des BMG</worktitle> [<number>128</number>]. </citation>
<citation id="_bib336" published="yes" workType="Journal"><workauthor>Bundesregierung</workauthor> (<pubdate>1996</pubdate>): <articletitle>Situation der Demenzkranken in der Bundesrepublik Deutschland</articletitle>, <worktitle>Deutscher Bundestag</worktitle> <volume>Drucksache 13/5257 13/5257</volume>. </citation>
<citation id="_bib79" published="yes" workType="Journal"><workauthor>Bush, A. I.; Pettingell, W. H.; Multhaup, G.; Paradis, M.; Vonsattel, J. P.; Gusella, J. F.; Beyreuther, K.; Masters, C. L. und Tanzi, R. E.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Rapid induction of Alzheimer A beta amyloid formation by zinc</articletitle>, <worktitle>Science</worktitle> <volume>265</volume> [<number>5177</number>], Seite <pages>1464</pages>-<pages>1467</pages>. </citation>
<citation id="_bib105" published="yes" workType="Journal"><workauthor>Carpentier, M.; Robitaille, Y.; DesGroseillers, L.; Boileau, G. und Marcinkiewicz, M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy</articletitle>, <worktitle>J Neuropathol.Exp Neurol.</worktitle> <volume>61</volume> [<number>10</number>], Seite <pages>849</pages>-<pages>856</pages>. </citation>
<citation id="_bib405" published="yes" workType="Journal"><workauthor>Carson, J. A. und Turner, A. J.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?</articletitle>, <worktitle>J Neurochem</worktitle> <volume>81</volume> [<number>1</number>], Seite <pages>1</pages>-<pages>8</pages>. </citation>
<citation id="_bib373" published="yes" workType="Journal"><workauthor>Chen, H.; Charlat, O.; Tartaglia, L. A.; Woolf, E. A.; Weng, X.; Ellis, S. J.; Lakey, N. D.; Culpepper, J.; Moore, K. J.; Breitbart, R. E.; Duyk, G. M.; Tepper, R. I. und Morgenstern, J. P.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice</articletitle>, <worktitle>Cell</worktitle> <volume>84</volume> [<number>3</number>], Seite <pages>491</pages>-<pages>495</pages>. </citation>
<citation id="_bib129" published="yes" workType="Journal"><workauthor>Clarimon, J.; Munoz, F. J.; Boada, M.; Tarraga, L.; Sunyer, J.; Bertranpetit, J. und Comas, D.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Possible increased risk for Alzheimer's disease associated with neprilysin gene</articletitle>, <worktitle>J Neural Transm.</worktitle> <volume>110</volume> [<number>6</number>], Seite <pages>651</pages>-<pages>657</pages>. </citation>
<citation id="_bib245" published="yes" workType="Journal"><workauthor>Connelly, J. C.; Skidgel, R. A.; Schulz, W. W.; Johnson, A. R. und Erdos, E. G.</workauthor> (<pubdate>1985</pubdate>): <articletitle>Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>82</volume> [<number>24</number>], Seite <pages>8737</pages>-<pages>8741</pages>. </citation>
<citation id="_bib366" published="yes" workType="Journal"><workauthor>Cowen, Michael S.; Chen, Feng und Lawrence, Andrew J.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Neuropeptides: implications for alcoholism</articletitle>, <worktitle>Journal of Neurochemistry</worktitle> <volume>89</volume> [<number>2</number>], Seite <pages>273</pages>-<pages>285</pages>. </citation>
<citation id="_bib370" published="yes" workType="Journal"><workauthor>Crabbe, J. C.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Genetic contributions to addiction</articletitle>, <worktitle>Annu.Rev.Psychol.</worktitle> <volume>53</volume>, Seite <pages>435</pages>-<pages>462</pages>. </citation>
<citation id="_bib174" published="yes" workType="Journal"><workauthor>Crabbe, John C.; Wahlsten, Douglas und Dudek, Bruce C.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Genetics of Mouse Behavior: Interactions with Laboratory Environment</articletitle>, <worktitle>Science</worktitle> <volume>284</volume> [<number>5420</number>], Seite <pages>1670</pages>-<pages>1672</pages>. </citation>
<citation id="_bib70" published="yes" workType="Journal"><workauthor>Curtain, C. C.; Ali, F.; Volitakis, I.; Cherny, R. A.; Norton, R. S.; Beyreuther, K.; Barrow, C. J.; Masters, C. L.; Bush, A. I. und Barnham, K. J.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>276</volume> [<number>23</number>], Seite <pages>20466</pages>-<pages>20473</pages>. </citation>
<citation id="_bib233" published="yes" workType="Journal"><workauthor>D'Adamio, L.; Shipp, M. A.; Masteller, E. L. und Reinherz, E. L.</workauthor> (<pubdate>1989</pubdate>): <articletitle>Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>86</volume> [<number>18</number>], Seite <pages>7103</pages>-<pages>7107</pages>. </citation>
<citation id="_bib283" published="yes" workType="Journal"><workauthor>d'Uscio, L. V.; Quaschning, T.; Burnett, J. C., Jr. und Luscher, T. F.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Vasopeptidase Inhibition Prevents Endothelial Dysfunction of Resistance Arteries in Salt-Sensitive Hypertension in Comparison With Single ACE Inhibition</articletitle>, <worktitle>Hypertension</worktitle> <volume>37</volume> [<number>1</number>], Seite <pages>28</pages>-<pages>33</pages>. </citation>
<citation id="_bib122" published="yes" workType="Journal"><workauthor>DeMattos, R. B.; Bales, K. R.; Cummins, D. J.; Paul, S. M. und Holtzman, D. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease</articletitle>, <worktitle>Science</worktitle> <volume>295</volume> [<number>5563</number>], Seite <pages>2264</pages>-<pages>2267</pages>. </citation>
<citation id="_bib198" published="yes" workType="Journal"><workauthor>Devault, A.; Lazure, C.; Nault, C.; Le Moual, H.; Seidah, N. G.; Chretien, M.; Kahn, P.; Powell, J.; Mallet, J.; Beaumont, A.; Roques, B. P.; Crine, P. und Boileau, G.</workauthor> (<pubdate>1987a</pubdate>): <articletitle>Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA</articletitle>, <worktitle>EMBO J</worktitle> <volume>6</volume> [<number>5</number>], Seite <pages>1317</pages>-<pages>1322</pages>. </citation>
<citation id="_bib249" published="yes" workType="Journal"><workauthor>Dion, N.; Cohen, P.; Crine, P. und Boileau, G.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Characterisation of neprilysin (EC 3.4.24.11) S2' subsite</articletitle>, <worktitle>FEBS Lett.</worktitle> <volume>411</volume> [<number>1</number>], Seite <pages>140</pages>-<pages>144</pages>. </citation>
<citation id="_bib343" published="yes" workType="Journal"><workauthor>Duhl, D. M.; Vrieling, H.; Miller, K. A.; Wolff, G. L. und Barsh, G. S.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Neomorphic agouti mutations in obese yellow mice</articletitle>, <worktitle>Nat Genet.</worktitle> <volume>8</volume> [<number>1</number>], Seite <pages>59</pages>-<pages>65</pages>. </citation>
<citation id="_bib409" published="yes" workType="Journal"><workauthor>During, M. J.; Cao, L.; Zuzga, D. S.; Francis, J. S.; Fitzsimons, H. L.; Jiao, X.; Bland, R. J.; Klugmann, M.; Banks, W. A.; Drucker, D. J. und Haile, C. N.</workauthor> (<pubdate>2003a</pubdate>): <articletitle>Glucagon-like peptide-1 receptor is involved in learning and neuroprotection</articletitle>, <worktitle>Nat Med</worktitle> <volume>9</volume> [<number>9</number>], Seite <pages>1173</pages>-<pages>1179</pages>. </citation>
<citation id="_bib210" published="yes" workType="Journal"><workauthor>Eckman, E. A.; Reed, D. K. und Eckman, C. B.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>276</volume> [<number>27</number>], Seite <pages>24540</pages>-<pages>24548</pages>. </citation>
<citation id="_bib381" published="yes" workType="Journal"><workauthor>Engeli, S.; Schling, P.; Gorzelniak, K.; Boschmann, M.; Janke, J.; Ailhaud, G.; Teboul, M.; Massiera, F. und Sharma, A. M.</workauthor> (<pubdate>2003b</pubdate>): <articletitle>The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?</articletitle>, <worktitle>Int.J Biochem Cell Biol</worktitle> <volume>35</volume> [<number>6</number>], Seite <pages>807</pages>-<pages>825</pages>. </citation>
<citation id="_bib364" published="yes" workType="Journal"><workauthor>Enoch, MA</workauthor> (<pubdate>2003</pubdate>): <articletitle>Pharmacogenomics of alcohol response and addiction</articletitle>, <worktitle>Am J Pharmacogenomics</worktitle> <volume>3</volume> [<number>4</number>], Seite <pages>217</pages>-<pages>232</pages>. </citation>
<citation id="_bib207" published="yes" workType="Journal"><workauthor>Esteban, J. A.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Living with the enemy: a physiological role for the beta-amyloid peptide</articletitle>, <worktitle>Trends Neurosci.</worktitle> <volume>27</volume> [<number>1</number>], Seite <pages>1</pages>-<pages>3</pages>. </citation>
<citation id="_bib434" published="yes" workType="Journal"><workauthor>Farooqi, I. S.; Matarese, G.; Lord, G. M.; Keogh, J. M.; Lawrence, E.; Agwu, C.; Sanna, V.; Jebb, S. A.; Perna, F.; Fontana, S.; Lechler, R. I.; DePaoli, A. M. und O'Rahilly, S.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency</articletitle>, <worktitle>J Clin Invest</worktitle> <volume>110</volume> [<number>8</number>], Seite <pages>1093</pages>-<pages>1103</pages>. </citation>
<citation id="_bib36" published="yes" workType="Journal"><workauthor>Fezoui, Y.; Hartley, D. M.; Harper, J. D.; Khurana, R.; Walsh, D. M.; Condron, M. M.; Selkoe, D. J.; Lansbury, P. T.; Fink, A. L. und Teplow, D. B.</workauthor> (<pubdate>2000b</pubdate>): <articletitle>An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments</articletitle>, <worktitle>Amyloid</worktitle> <volume>7</volume> [<number>3</number>], Seite <pages>166</pages>-<pages>178</pages>. </citation>
<citation id="_bib218" published="yes" workType="Journal"><workauthor>Findlay, G. S.; Wick, M. J.; Mascia, M. P.; Wallace, D.; Miller, G. W.; Harris, R. A. und Blednov, Y. A.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice</articletitle>, <worktitle>J Pharmacol.Exp Ther.</worktitle> <volume>300</volume> [<number>2</number>], Seite <pages>526</pages>-<pages>534</pages>. </citation>
<citation id="_bib56" published="yes" workType="Journal"><workauthor>Francis, R.; McGrath, G.; Zhang, J.; Ruddy, D. A.; Sym, M.; Apfeld, J.; Nicoll, M.; Maxwell, M.; Hai, B.; Ellis, M. C.; Parks, A. L.; Xu, W.; Li, J.; Gurney, M.; Myers, R. L.; Himes, C. S.; Hiebsch, R.; Ruble, C.; Nye, J. S. und Curtis, D.</workauthor> (<pubdate>2002</pubdate>): <articletitle>aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation</articletitle>, <worktitle>Dev Cell</worktitle> <volume>3</volume> [<number>1</number>], Seite <pages>85</pages>-<pages>97</pages>. </citation>
<citation id="_bib68" published="yes" workType="Journal"><workauthor>Fraser, P. E.; Nguyen, J. T.; Inouye, H.; Surewicz, W. K.; Selkoe, D. J.; Podlisny, M. B. und Kirschner, D. A.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein</articletitle>, <worktitle>Biochemistry</worktitle> <volume>31</volume> [<number>44</number>], Seite <pages>10716</pages>-<pages>10723</pages>. </citation>
<citation id="_bib9" published="yes" workType="Journal"><workauthor>Frette, Catherine; Pezet, Sophie; El Nabout, Rita Azzi; Bertrand, Jean-Pierre; Pham, Quang Thieu; Kauffmann, Francine und Lafuma, Chantal</workauthor> (<pubdate>1998b</pubdate>): <articletitle>Relationship of serum neutral endopeptidase E.C.3.4.24.11 activity to alcohol consumption</articletitle>, <worktitle>Alcohol Clin Exp Res</worktitle> <volume>22</volume> [<number>7</number>], Seite <pages>1405</pages>-<pages>1408</pages>. </citation>
<citation id="_bib238" published="yes" workType="Journal"><workauthor>Fricker, L. D.; Berman, Y. L.; Leiter, E. H. und Devi, L. A.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>271</volume> [<number>48</number>], Seite <pages>30619</pages>-<pages>30624</pages>. </citation>
<citation id="_bib28" published="yes" workType="Journal"><workauthor>Friedland, J. und Silverstein, E.</workauthor> (<pubdate>1976</pubdate>): <articletitle>A sensitive fluorimetric assay for serum angiotensin-converting enzyme</articletitle>, <worktitle>Am J Clin Pathol</worktitle> <volume>66</volume> [<number>2</number>], Seite <pages>416</pages>-<pages>424</pages>. </citation>
<citation id="_bib231" published="yes" workType="Journal"><workauthor>Fulcher, I. S. und Kenny, A. J.</workauthor> (<pubdate>1983</pubdate>): <articletitle>Proteins of the kidney microvillar membrane. The amphipathic forms of endopeptidase purified from pig kidneys</articletitle>, <worktitle>Biochem J</worktitle> <volume>211</volume> [<number>3</number>], Seite <pages>743</pages>-<pages>753</pages>. </citation>
<citation id="_bib281" published="yes" workType="Journal"><workauthor>GeneCards</workauthor> (<pubdate>2004</pubdate>):  <url href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=Retrieve&amp;dopt=summary&amp;list_uids=4311" type="URL">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=Retrieve&amp;dopt=summary&amp;list_uids=4311</url>. </citation>
<citation id="_bib319" published="yes" workType="Journal"><workauthor>George, S. R.; Roldan, L.; Lui, A. und Naranjo, C. A.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Endogenous opioids are involved in the genetically determined high preference for ethanol consumption</articletitle>, <worktitle>Alcohol Clin Exp Res</worktitle> <volume>15</volume> [<number>4</number>], Seite <pages>668</pages>-<pages>672</pages>. </citation>
<citation id="_bib3" published="yes" workType="Journal"><workauthor>Gianoulakis, C.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Endogenous opioids and addiction to alcohol and other drugs of abuse</articletitle>, <worktitle>Curr.Top.Med.Chem.</worktitle> <volume>4</volume> [<number>1</number>], Seite <pages>39</pages>-<pages>50</pages>. URL: <url href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Citation&amp;list_uids=14754375" type="URL">PM:14754375</url> </citation>
<citation id="_bib47" published="yes" workType="Journal"><workauthor>Glenner, G. G. und Wong, C. W.</workauthor> (<pubdate>1984</pubdate>): <articletitle>Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein</articletitle>, <worktitle>Biochem Biophys.Res Commun.</worktitle> <volume>120</volume> [<number>3</number>], Seite <pages>885</pages>-<pages>890</pages>. </citation>
<citation id="_bib358" published="yes" workType="Journal"><workauthor>Gordon, H. W.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Early environmental stress and biological vulnerability to drug abuse</articletitle>, <worktitle>Psychoneuroendocrinology</worktitle> <volume>27</volume> [<number>1-2</number>], Seite <pages>115</pages>-<pages>126</pages>. </citation>
<citation id="_bib326" published="yes" workType="Journal"><workauthor>Grupp, L. A.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Effects of angiotensin II and an angiotensin converting enzyme inhibitor on alcohol intake in P and NP rats</articletitle>, <worktitle>Pharmacol.Biochem Behav.</worktitle> <volume>41</volume> [<number>1</number>], Seite <pages>105</pages>-<pages>108</pages>. </citation>
<citation id="_bib325" published="yes" workType="Journal"><workauthor>Grupp, L. A. und Chow, S. Y.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Time-dependent effect of the angiotensin converting enzyme inhibitor, abutapril, on voluntary alcohol intake in the rat</articletitle>, <worktitle>Alcohol Alcohol</worktitle> <volume>27</volume> [<number>3</number>], Seite <pages>267</pages>-<pages>271</pages>. </citation>
<citation id="_bib408" published="yes" workType="Journal"><workauthor>Gulpinar, M. A. und Yegen, B. C.</workauthor> (<pubdate>2004</pubdate>): <articletitle>The physiology of learning and memory: role of peptides and stress</articletitle>, <worktitle>Curr.Protein Pept.Sci.</worktitle> <volume>5</volume> [<number>6</number>], Seite <pages>457</pages>-<pages>473</pages>. </citation>
<citation id="_bib344" published="yes" workType="Journal"><workauthor>Haemmerle, G.; Zimmermann, R.; Hayn, M.; Theussl, C.; Waeg, G.; Wagner, E.; Sattler, W.; Magin, T. M.; Wagner, E. F. und Zechner, R.</workauthor> (<pubdate>2002b</pubdate>): <articletitle>Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>277</volume> [<number>7</number>], Seite <pages>4806</pages>-<pages>4815</pages>. </citation>
<citation id="_bib93" published="yes" workType="Journal"><workauthor>Hama, E.; Shirotani, K.; Masumoto, H.; Sekine-Aizawa, Y.; Aizawa, H. und Saido, T. C.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons</articletitle>, <worktitle>Journal of Biochemistry</worktitle> <volume>130</volume> [<number>6</number>], Seite <pages>721</pages>-<pages>726</pages>. </citation>
<citation id="_bib112" published="yes" workType="Journal"><workauthor>Hardy, J. und Selkoe, D. J.</workauthor> (<pubdate>2002</pubdate>): <articletitle>The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics</articletitle>, <worktitle>Science</worktitle> <volume>297</volume> [<number>5580</number>], Seite <pages>353</pages>-<pages>356</pages>. </citation>
<citation id="_bib375" published="yes" workType="Journal"><workauthor>Heimann, A. S.; Favarato, M. H.; Gozzo, F. C.; Rioli, V.; Carreno, F. R.; Eberlin, M. N.; Ferro, E. S.; Krege, J. H. und Krieger, J. E.</workauthor> (<pubdate>2004</pubdate>): <articletitle>ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight</articletitle>, <worktitle>Physiol Genomics</worktitle>. </citation>
<citation id="_bib345" published="yes" workType="Journal"><workauthor>Helin, K.; Tikkanen, I.; Hohenthal, U. und Fyhrquist, F.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Inhibition of either angiotensin-converting enzyme or neutral endopeptidase induces both enzymes</articletitle>, <worktitle>Eur.J Pharmacol.</worktitle> <volume>264</volume> [<number>2</number>], Seite <pages>135</pages>-<pages>141</pages>. </citation>
<citation id="_bib338" published="yes" workType="Journal"><workauthor>Herpertz, S</workauthor> (<pubdate>2003</pubdate>): <articletitle>Psychotherapie der Adipositas</articletitle>, <worktitle>Dtsch Arztebl</worktitle> <volume>100</volume> [<number>20</number>], Seite <pages>A1367</pages>-<pages>A1373</pages>. </citation>
<citation id="_bib67" published="yes" workType="Journal"><workauthor>Hilbich, C.; Kisters-Woike, B.; Reed, J.; Masters, C. L. und Beyreuther, K.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4</articletitle>, <worktitle>Eur.J Biochem</worktitle> <volume>201</volume> [<number>1</number>], Seite <pages>61</pages>-<pages>69</pages>. </citation>
<citation id="_bib191" published="yes" workType="Journal"><workauthor>Hill, J. O.; Wyatt, H. R.; Reed, G. W. und Peters, J. C.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Obesity and the environment: where do we go from here?</articletitle>, <worktitle>Science</worktitle> <volume>299</volume> [<number>5608</number>], Seite <pages>853</pages>-<pages>855</pages>. </citation>
<citation id="_bib237" published="yes" workType="Journal"><workauthor>Hirsch, J.; Leibel, R. L. und Chua, S. C.</workauthor> (<pubdate>1992</pubdate>): <articletitle>A clinical perspective on peptides and food intake</articletitle>, <worktitle>Am J Clin Nutr.</worktitle> <volume>55</volume> [<number>1 Suppl</number>], Seite <pages>296S</pages>-<pages>298S</pages>. URL: <url href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Citation&amp;list_uids=1728843" type="URL">PM:1728843</url> </citation>
<citation id="_bib50" published="yes" workType="Journal"><workauthor>Howell, S.; Nalbantoglu, J. und Crine, P.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism</articletitle>, <worktitle>Peptides</worktitle> <volume>16</volume> [<number>4</number>], Seite <pages>647</pages>-<pages>652</pages>. </citation>
<citation id="_bib212" published="yes" workType="Journal"><workauthor>Hu, J.; Igarashi, A.; Kamata, M. und Nakagawa, H.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>276</volume> [<number>51</number>], Seite <pages>47863</pages>-<pages>47868</pages>. </citation>
<citation id="_bib75" published="yes" workType="Journal"><workauthor>Huang, X.; Cuajungco, M. P.; Atwood, C. S.; Hartshorn, M. A.; Tyndall, J. D.; Hanson, G. R.; Stokes, K. C.; Leopold, M.; Multhaup, G.; Goldstein, L. E.; Scarpa, R. C.; Saunders, A. J.; Lim, J.; Moir, R. D.; Glabe, C.; Bowden, E. F.; Masters, C. L.; Fairlie, D. P.; Tanzi, R. E. und Bush, A. I.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>274</volume> [<number>52</number>], Seite <pages>37111</pages>-<pages>37116</pages>. </citation>
<citation id="_bib41" published="yes" workType="Book"><workauthor>Hulme, E. C.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Receptor preparations for binding studies</articletitle>, <editor>Hulme, E. C.</editor>, <worktitle>Receptor--Ligand Interactions, a Practical Approach</worktitle> , <publisher>IRL Press</publisher>. </citation>
<citation id="_bib268" published="yes" workType="Journal"><workauthor>Hupe-Sodmann, K.; Goke, R.; Goke, B.; Thole, H. H.; Zimmermann, B.; Voigt, K. und McGregor, G. P.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Endoproteolysis of glucagon-like peptide (GLP)-1 (7-36) amide by ectopeptidases in RINm5F cells</articletitle>, <worktitle>Peptides</worktitle> <volume>18</volume> [<number>5</number>], Seite <pages>625</pages>-<pages>632</pages>. </citation>
<citation id="_bib369" published="yes" workType="Journal"><workauthor>Hwang, B. H.; Stewart, R.; Zhang, J. K.; Lumeng, L. und Li, T. K.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Corticotropin-releasing factor gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: a comparison between rat lines selectively bred for high and low alcohol preference</articletitle>, <worktitle>Brain Res</worktitle> <volume>1026</volume> [<number>1</number>], Seite <pages>143</pages>-<pages>150</pages>. </citation>
<citation id="_bib101" published="yes" workType="Journal"><workauthor>Iwata, N.; Takaki, Y.; Fukami, S.; Tsubuki, S. und Saido, T. C.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging</articletitle>, <worktitle>J Neurosci.Res</worktitle> <volume>70</volume> [<number>3</number>], Seite <pages>493</pages>-<pages>500</pages>. </citation>
<citation id="_bib100" published="yes" workType="Journal"><workauthor>Iwata, N.; Tsubuki, S.; Takaki, Y.; Shirotani, K.; Lu, B.; Gerard, N. P.; Gerard, C.; Hama, E.; Lee, H. J. und Saido, T. C.</workauthor> (<pubdate>2001d</pubdate>): <articletitle>Metabolic regulation of brain Abeta by neprilysin</articletitle>, <worktitle>Science</worktitle> <volume>292</volume> [<number>5521</number>], Seite <pages>1550</pages>-<pages>1552</pages>. </citation>
<citation id="_bib99" published="yes" workType="Journal"><workauthor>Iwata, N.; Tsubuki, S.; Takaki, Y.; Watanabe, K.; Sekiguchi, M.; Hosoki, E.; Kawashima-Morishima, M.; Lee, H. J.; Hama, E.; Sekine-Aizawa, Y. und Saido, T. C.</workauthor> (<pubdate>2000b</pubdate>): <articletitle>Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition</articletitle>, <worktitle>Nat Med.</worktitle> <volume>6</volume> [<number>2</number>], Seite <pages>143</pages>-<pages>150</pages>. </citation>
<citation id="_bib429" published="yes" workType="Journal"><workauthor>Iwata, Nobuhisa; Higuchi, Makoto und Saido, Takaomi C.</workauthor> (<pubdate>2005a</pubdate>): <articletitle>Metabolism of amyloid beta peptide and Alzheimer's disease</articletitle>, <worktitle>Pharmacol.Thera.</worktitle> <volume>108</volume> [<number>2</number>], Seite <pages>129</pages>-<pages>148</pages>. </citation>
<citation id="_bib31" published="yes" workType="Journal"><workauthor>Iwata, Nobuhisa; Mizukami, Hiroaki; Shirotani, Keiro; Takaki, Yoshie; Muramatsu, Shin ichi; Lu, Bao; Gerard, Norma P.; Gerard, Craig; Ozawa, Keiya und Saido, Takaomi C.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-{beta} Peptide in Mouse Brain</articletitle>, <worktitle>Journal of Neuroscience</worktitle> <volume>24</volume> [<number>4</number>], Seite <pages>991</pages>-<pages>998</pages>. </citation>
<citation id="_bib261" published="yes" workType="Journal"><workauthor>Jacobowitz, David M.; Kresse, Adelheid und Skofitsch, Gerhard</workauthor> (<pubdate>2004</pubdate>): <articletitle>Galanin in the brain: chemoarchitectonics and brain cartography--a historical review*1</articletitle>, <worktitle>Peptides</worktitle> <volume>25</volume> [<number>3</number>], Seite <pages>433</pages>-<pages>464</pages>. </citation>
<citation id="_bib116" published="yes" workType="Journal"><workauthor>Janek, K.; Rothemund, S.; Gast, K.; Beyermann, M.; Zipper, J.; Fabian, H.; Bienert, M. und Krause, E.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Study of the conformational transition of A beta(1-42) using D-amino acid replacement analogues</articletitle>, <worktitle>Biochemistry</worktitle> <volume>40</volume> [<number>18</number>], Seite <pages>5457</pages>-<pages>5463</pages>. </citation>
<citation id="_bib350" published="yes" workType="Journal"><workauthor>Jansen, S.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Welt-Alzheimertag</articletitle>, <worktitle>Pharm.Ztg.</worktitle> <volume>149</volume> [<number>38</number>], Seite <pages>46</pages>-<pages>46</pages>. </citation>
<citation id="_bib64" published="yes" workType="Journal"><workauthor>Johnstone, E. M.; Chaney, M. O.; Norris, F. H.; Pascual, R. und Little, S. P.</workauthor> (<pubdate>1991a</pubdate>): <articletitle>Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis</articletitle>, <worktitle>Brain Res Mol.Brain Res</worktitle> <volume>10</volume> [<number>4</number>], Seite <pages>299</pages>-<pages>305</pages>. </citation>
<citation id="_bib196" published="yes" workType="Book"><workauthor>Kenny, A. J.</workauthor> (<pubdate>1977</pubdate>): <articletitle>Proteinases associated with cell membranes</articletitle>, <editor>Barrett, A. J.</editor>, <worktitle>Proteinases in Mammalian Cells and Tissues</worktitle> , Seite <pages>393</pages>-<pages>444</pages>, <publisher>Elsevier</publisher>, <address>Amsterdam</address>. </citation>
<citation id="_bib250" published="yes" workType="Journal"><workauthor>Kenny, A. J. und Stephenson, S. L.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Role of endopeptidase-24.11 in the inactivation of atrial natriuretic peptide</articletitle>, <worktitle>FEBS Lett.</worktitle> <volume>232</volume> [<number>1</number>], Seite <pages>1</pages>-<pages>8</pages>. </citation>
<citation id="_bib194" published="yes" workType="Journal"><workauthor>Kerr, M. A. und Kenny, A. J.</workauthor> (<pubdate>1974</pubdate>): <articletitle>The purification and specificity of a neutral endopeptidase from rabbit kidney brush border</articletitle>, <worktitle>Biochem J</worktitle> <volume>137</volume> [<number>3</number>], Seite <pages>477</pages>-<pages>488</pages>. </citation>
<citation id="_bib428" published="yes" workType="Journal"><workauthor>Klaus, S.; Pultz, S.; Thone-Reineke, C. und Wolfram, S.</workauthor> (<pubdate>2005</pubdate>): <articletitle>Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation</articletitle>, <worktitle>Int.J Obesity</worktitle> <volume>29</volume>, Seite <pages>615</pages>-<pages>623</pages>. </citation>
<citation id="_bib354" published="yes" workType="Journal"><workauthor>Kleyn, P. W.; Fan, W.; Kovats, S. G.; Lee, J. J.; Pulido, J. C.; Wu, Y.; Berkemeier, L. R.; Misumi, D. J.; Holmgren, L.; Charlat, O.; Woolf, E. A.; Tayber, O.; Brody, T.; Shu, P.; Hawkins, F.; Kennedy, B.; Baldini, L.; Ebeling, C.; Alperin, G. D.; Deeds, J.; Lakey, N. D.; Culpepper, J.; Chen, H.; Glucksmann-Kuis, M. A.; Moore, K. J. und .</workauthor> (<pubdate>1996</pubdate>): <articletitle>Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family</articletitle>, <worktitle>Cell</worktitle> <volume>85</volume> [<number>2</number>], Seite <pages>281</pages>-<pages>290</pages>. </citation>
<citation id="_bib217" published="yes" workType="Journal"><workauthor>Koolhaas, J. M.; De Boer, S. F.; De Rutter, A. J.; Meerlo, P. und Sgoifo, A.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Social stress in rats and mice</articletitle>, <worktitle>Acta Physiol Scand.Suppl</worktitle> <volume>640</volume>, Seite <pages>69</pages>-<pages>72</pages>. </citation>
<citation id="_bib192" published="yes" workType="Journal"><workauthor>Kordik, C. P. und Reitz, A. B.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Pharmacological treatment of obesity: therapeutic strategies</articletitle>, <worktitle>J Med Chem.</worktitle> <volume>42</volume> [<number>2</number>], Seite <pages>181</pages>-<pages>201</pages>. </citation>
<citation id="_bib188" published="yes" workType="Journal"><workauthor>Kral, J. G.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Morbidity of severe obesity</articletitle>, <worktitle>Surg.Clin North Am</worktitle> <volume>81</volume> [<number>5</number>], Seite <pages>1039</pages>-<pages>1061</pages>. </citation>
<citation id="_bib184" published="yes" workType="Journal"><workauthor>Künast, Renate</workauthor> (<pubdate>2004</pubdate>): <articletitle>Plattform "Ernährung und Bewegung" - Gemeinsame Erklärung zwischen Bundesverbraucherministerium und der Lebensmittel-wirtschaft über die Errichtung einer gesamtgesellschaftlichen Plattform zur Förderung von Maßnahmen der Ernährungsaufklärung und der Steigerung der körperlichen Aktivität bei Kindern und Jugendlichen zur Prävention von Übergewicht.</articletitle>, <worktitle>Pressemitteilung Nr.38 vom 11.Februar 2004</worktitle>. URL: <url href="http://www.verbraucherministerium.de/index-000C07D0943F102B8D2A6521C0A8D816.html" type="URL">http://www.verbraucherministerium.de/index-000C07D0943F102B8D2A6521C0A8D816.html</url> </citation>
<citation id="_bib301" published="yes" workType="Journal"><workauthor>Kuo, Y. M.; Emmerling, M. R.; Vigo-Pelfrey, C.; Kasunic, T. C.; Kirkpatrick, J. B.; Murdoch, G. H.; Ball, M. J. und Roher, A. E.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains</articletitle>, <worktitle>Journal of Biological Chemistry</worktitle> <volume>271</volume> [<number>8</number>], Seite <pages>4077</pages>-<pages>4081</pages>. </citation>
<citation id="_bib263" published="yes" workType="Journal"><workauthor>Leibowitz, Sarah F. und Wortley, Katherine E.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Hypothalamic control of energy balance: different peptides, different functions*1</articletitle>, <worktitle>Peptides</worktitle> <volume>25</volume> [<number>3</number>], Seite <pages>473</pages>-<pages>504</pages>. </citation>
<citation id="_bib30" published="yes" workType="Journal"><workauthor>Leissring, M. A.; Farris, W.; Chang, A. Y.; Walsh, D. M.; Wu, X.; Sun, X.; Frosch, M. P. und Selkoe, D. J.</workauthor> (<pubdate>2003c</pubdate>): <articletitle>Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death</articletitle>, <worktitle>Neuron</worktitle> <volume>40</volume> [<number>6</number>], Seite <pages>1087</pages>-<pages>1093</pages>. </citation>
<citation id="_bib199" published="yes" workType="Journal"><workauthor>Letarte, M.; Vera, S.; Tran, R.; Addis, J. B.; Onizuka, R. J.; Quackenbush, E. J.; Jongeneel, C. V. und McInnes, R. R.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase</articletitle>, <worktitle>J Exp Med</worktitle> <volume>168</volume> [<number>4</number>], Seite <pages>1247</pages>-<pages>1253</pages>. </citation>
<citation id="_bib277" published="yes" workType="Journal"><workauthor>Li, W.; Moore, M. J.; Vasilieva, N.; Sui, J.; Wong, S. K.; Berne, M. A.; Somasundaran, M.; Sullivan, J. L.; Luzuriaga, K.; Greenough, T. C.; Choe, H. und Farzan, M.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus</articletitle>, <worktitle>Nature</worktitle> <volume>426</volume> [<number>6965</number>], Seite <pages>450</pages>-<pages>454</pages>. </citation>
<citation id="_bib65" published="yes" workType="Journal"><workauthor>Liu, S. T.; Howlett, G. und Barrow, C. J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease</articletitle>, <worktitle>Biochemistry</worktitle> <volume>38</volume> [<number>29</number>], Seite <pages>9373</pages>-<pages>9378</pages>. </citation>
<citation id="_bib205" published="yes" workType="Journal"><workauthor>Lu, B.; Gerard, N. P.; Kolakowski, L. F., Jr.; Bozza, M.; Zurakowski, D.; Finco, O.; Carroll, M. C. und Gerard, C.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Neutral endopeptidase modulation of septic shock</articletitle>, <worktitle>J Exp Med</worktitle> <volume>181</volume> [<number>6</number>], Seite <pages>2271</pages>-<pages>2275</pages>. </citation>
<citation id="_bib300" published="yes" workType="Journal"><workauthor>Lue, L. F.; Kuo, Y. M.; Roher, A. E.; Brachova, L.; Shen, Y.; Sue, L.; Beach, T.; Kurth, J. H.; Rydel, R. E. und Rogers, J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease</articletitle>, <worktitle>Am.J.Pathol.</worktitle> <volume>155</volume> [<number>3</number>], Seite <pages>853</pages>-<pages>862</pages>. </citation>
<citation id="_bib228" published="yes" workType="Journal"><workauthor>Malfroy, B.; Kuang, W. J.; Seeburg, P. H.; Mason, A. J. und Schofield, P. R.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)</articletitle>, <worktitle>FEBS Lett</worktitle> <volume>229</volume> [<number>1</number>], Seite <pages>206</pages>-<pages>210</pages>. </citation>
<citation id="_bib229" published="yes" workType="Journal"><workauthor>Malfroy, B.; Schofield, P. R.; Kuang, W. J.; Seeburg, P. H.; Mason, A. J. und Henzel, W. J.</workauthor> (<pubdate>1987</pubdate>): <articletitle>Molecular cloning and amino acid sequence of rat enkephalinase</articletitle>, <worktitle>Biochem Biophys.Res Commun.</worktitle> <volume>144</volume> [<number>1</number>], Seite <pages>59</pages>-<pages>66</pages>. </citation>
<citation id="_bib197" published="yes" workType="Journal"><workauthor>Malfroy, B.; Swerts, J. P.; Guyon, A.; Roques, B. P. und Schwartz, J. C.</workauthor> (<pubdate>1978b</pubdate>): <articletitle>High-affinity enkephalin-degrading peptidase in brain is increased after morphine</articletitle>, <worktitle>Nature</worktitle> <volume>276</volume> [<number>5687</number>], Seite <pages>523</pages>-<pages>526</pages>. </citation>
<citation id="_bib49" published="yes" workType="Journal"><workauthor>Mann, D. M.</workauthor> (<pubdate>1988</pubdate>): <articletitle>The pathological association between Down syndrome and Alzheimer disease</articletitle>, <worktitle>Mech.Ageing Dev.</worktitle> <volume>43</volume> [<number>2</number>], Seite <pages>99</pages>-<pages>136</pages>. </citation>
<citation id="_bib284" published="yes" workType="Journal"><workauthor>Marcic, B.; Deddish, P. A.; Jackman, H. L. und Erdos, E. G.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Enhancement of bradykinin and resensitization of its B2 receptor</articletitle>, <worktitle>Hypertension</worktitle> <volume>33</volume> [<number>3</number>], Seite <pages>835</pages>-<pages>843</pages>. </citation>
<citation id="_bib106" published="yes" workType="Journal"><workauthor>Marr, R. A.; Guan, H.; Rockenstein, E.; Kindy, M.; Gage, F. H.; Verma, I.; Masliah, E. und Hersh, L. B.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Neprilysin regulates amyloid Beta peptide levels</articletitle>, <worktitle>J Mol.Neurosci.</worktitle> <volume>22</volume> [<number>1-2</number>], Seite <pages>5</pages>-<pages>11</pages>. </citation>
<citation id="_bib4" published="yes" workType="Journal"><workauthor>Marr, Robert A.; Rockenstein, Edward; Mukherjee, Atish; Kindy, Mark S.; Hersh, Louis B.; Gage, Fred H.; Verma, Inder M. und Masliah, Eliezer</workauthor> (<pubdate>2003a</pubdate>): <articletitle>Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice</articletitle>, <worktitle>Journal of Neuroscience</worktitle> <volume>23</volume> [<number>6</number>], Seite <pages>1992</pages>-<pages>1996</pages>. </citation>
<citation id="_bib253" published="yes" workType="Journal"><workauthor>Matsas, R.; Kenny, A. J. und Turner, A. J.</workauthor> (<pubdate>1984b</pubdate>): <articletitle>The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11</articletitle>, <worktitle>Biochem J</worktitle> <volume>223</volume> [<number>2</number>], Seite <pages>433</pages>-<pages>440</pages>. </citation>
<citation id="_bib16" published="yes" workType="Journal"><workauthor>Maul, B.; Siems, W. E.; Hoehe, M. R.; Grecksch, G.; Bader, M. und Walther, T.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Alcohol consumption is controlled by angiotensin II</articletitle>, <worktitle>FASEB J.</worktitle> <volume>15</volume> [<number>9</number>], Seite <pages>1640</pages>-<pages>1642</pages>. </citation>
<citation id="_bib280" published="yes" workType="Book"><workauthor>McDonald, J. K.</workauthor> (<pubdate>1986</pubdate>): <articletitle>Exopeptidases</articletitle>, <worktitle>Mammalian Proteases</worktitle> , <publisher>Academic Press</publisher>, <address>London</address>. </citation>
<citation id="_bib298" published="yes" workType="Journal"><workauthor>McLean, C. A.; Cherny, R. A.; Fraser, F. W.; Fuller, S. J.; Smith, M. J.; Beyreuther, K.; Bush, A. I. und Masters, C. L.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease</articletitle>, <worktitle>Ann.Neurol.</worktitle> <volume>46</volume> [<number>6</number>], Seite <pages>860</pages>-<pages>866</pages>. </citation>
<citation id="_bib421" published="yes" workType="Journal"><workauthor>Melzig, M. F. und Escher, F</workauthor> (<pubdate>2002a</pubdate>): <articletitle>Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.</articletitle>, <worktitle>Pharmazie</worktitle> <volume>57</volume> [<number>8</number>], Seite <pages>556</pages>-<pages>558</pages>. </citation>
<citation id="_bib420" published="yes" workType="Journal"><workauthor>Melzig, M. F. und Janka, M</workauthor> (<pubdate>2003b</pubdate>): <articletitle>Enhancement of neutral endopeptidase activity in SK-N-SH cells by green tea extract.</articletitle>, <worktitle>Phytomedicine</worktitle> <volume>10</volume> [<number>6-7</number>], Seite <pages>494</pages>-<pages>498</pages>. </citation>
<citation id="_bib19" published="yes" workType="Journal"><workauthor>Melzig, M. F.; Papsdorf, G.; Putscher, I.; Winkler, A. und Siems, W. E.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Inhibition of corticotropin releasing factor (CRF)-induced adrenocorticotropin (ACTH) secretion in pituitary corticotropic cells by substance P</articletitle>, <worktitle>Pharmazie</worktitle> <volume>53</volume> [<number>8</number>], Seite <pages>569</pages>-<pages>572</pages>. </citation>
<citation id="_bib396" published="yes" workType="Book"><workauthor>Menke, K. H. und Huss, W.</workauthor> (<pubdate>1980</pubdate>): <worktitle>Tierernährung und Futtermittelkunde.</worktitle>, <edition>2. Auflage</edition>. Auflage . </citation>
<citation id="_bib308" published="yes" workType="Journal"><workauthor>Messing, R. O. und Diamond, I</workauthor> (<pubdate>2001</pubdate>): <articletitle>Alcoholism</articletitle>, <worktitle>Encyclopedia of Life Sciences</worktitle>. URL: <url href="http://dx.doi.org/10.1038/npg.els.0003929" type="URL">http://dx.doi.org/10.1038/npg.els.0003929</url> </citation>
<citation id="_bib169" published="yes" workType="Journal"><workauthor>Miller, Bonnie C.; Eckman, Elizabeth A.; Sambamurti, Kumar; Dobbs, Nicole; Chow, K. Martin; Eckman, Christopher B.; Hersh, Louis B. und Thiele, Dwain L.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo</articletitle>, <worktitle>Proceedings of the National Academy of Sciences</worktitle> <volume>100</volume> [<number>10</number>], Seite <pages>6221</pages>-<pages>6226</pages>. </citation>
<citation id="_bib95" published="yes" workType="Journal"><workauthor>Mohajeri, M. H.; Wollmer, M. A. und Nitsch, R. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>277</volume> [<number>38</number>], Seite <pages>35460</pages>-<pages>35465</pages>. </citation>
<citation id="_bib185" published="yes" workType="Journal"><workauthor>Mokdad, A. H.; Bowman, B. A.; Ford, E. S.; Vinicor, F.; Marks, J. S. und Koplan, J. P.</workauthor> (<pubdate>2001</pubdate>): <articletitle>The continuing epidemics of obesity and diabetes in the United States</articletitle>, <worktitle>JAMA</worktitle> <volume>286</volume> [<number>10</number>], Seite <pages>1195</pages>-<pages>1200</pages>. </citation>
<citation id="_bib410" published="yes" workType="Journal"><workauthor>Moller, C.; Sommer, W.; Thorsell, A.; Rimondini, R. und Heilig, M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test</articletitle>, <worktitle>Prog.Neuropsychopharmacol.Biol Psychiatry</worktitle> <volume>26</volume> [<number>1</number>], Seite <pages>119</pages>-<pages>122</pages>. </citation>
<citation id="_bib223" published="yes" workType="Journal"><workauthor>Morgan, D.; Grant, K. A.; Gage, H. D.; Mach, R. H.; Kaplan, J. R.; Prioleau, O.; Nader, S. H.; Buchheimer, N.; Ehrenkaufer, R. L. und Nader, M. A.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration</articletitle>, <worktitle>Nat Neurosci</worktitle> <volume>5</volume> [<number>2</number>], Seite <pages>169</pages>-<pages>174</pages>. </citation>
<citation id="_bib208" published="yes" workType="Journal"><workauthor>Mukherjee, A.; Song, E.; Kihiko-Ehmann, M.; Goodman, J. P., Jr.; Pyrek, J. S.; Estus, S. und Hersh, L. B.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques</articletitle>, <worktitle>J Neurosci.</worktitle> <volume>20</volume> [<number>23</number>], Seite <pages>8745</pages>-<pages>8749</pages>. </citation>
<citation id="_bib431" published="yes" workType="Book"><workauthor>Mutschler, E.; Geisslinger, G.; Kroemer, H. K. und Schäfer-Korting, M.</workauthor> (<pubdate>2001</pubdate>): <worktitle>Arzneimittelwirkungen. Lehrbuch der Pharmakologie und Toxikologie.</worktitle>, <edition>8</edition>. Auflage , <publisher>Wissenschaftliche Verlagsgesellschaft mbH</publisher>, <address>Stuttgart</address>. </citation>
<citation id="_bib239" published="yes" workType="Journal"><workauthor>Naggert, J. K.; Fricker, L. D.; Varlamov, O.; Nishina, P. M.; Rouille, Y.; Steiner, D. F.; Carroll, R. J.; Paigen, B. J. und Leiter, E. H.</workauthor> (<pubdate>1995a</pubdate>): <articletitle>Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity</articletitle>, <worktitle>Nat Genet.</worktitle> <volume>10</volume> [<number>2</number>], Seite <pages>135</pages>-<pages>142</pages>. </citation>
<citation id="_bib365" published="yes" workType="Journal"><workauthor>National Institute on Alcohol Abuse and Alcoholism (NIAAA)</workauthor> (<pubdate>1992</pubdate>): <articletitle>The genetics of alcoholism</articletitle>, <worktitle>Alcohol Alert</worktitle> <volume>18</volume>. URL: <url href="http://pubs.niaaa.nih.gov/publications/aa18.htm" type="URL">http://pubs.niaaa.nih.gov/publications/aa18.htm</url> </citation>
<citation id="_bib220" published="yes" workType="Journal"><workauthor>Nestler, E. J.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Molecular basis of long-term plasticity underlying addiction</articletitle>, <worktitle>Nat Rev.Neurosci.</worktitle> <volume>2</volume> [<number>2</number>], Seite <pages>119</pages>-<pages>128</pages>. </citation>
<citation id="_bib435" published="yes" workType="Journal"><workauthor>North, M. A.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Advances in the molecular genetics of obesity.</articletitle>, <worktitle>Curr.Opin.Genet.Dev.</worktitle> <volume>9</volume> [<number>3</number>], Seite <pages>283</pages>-<pages>288</pages>. </citation>
<citation id="_bib386" published="yes" workType="Journal"><workauthor>O'Callaghan, J.; Croft, P. und Little, H. J.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Effects of intraperitoneal injections of saline on the alcohol and sucrose consumption of C57/BL10 mice</articletitle>, <worktitle>Psychopharmacology (Berl)</worktitle> <volume>160</volume>, Seite <pages>206</pages>-<pages>212</pages>. </citation>
<citation id="_bib254" published="yes" workType="Journal"><workauthor>Oefner, C.; D'Arcy, A.; Hennig, M.; Winkler, F. K. und Dale, G. E.</workauthor> (<pubdate>2000b</pubdate>): <articletitle>Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon</articletitle>, <worktitle>J Mol.Biol</worktitle> <volume>296</volume> [<number>2</number>], Seite <pages>341</pages>-<pages>349</pages>. </citation>
<citation id="_bib359" published="yes" workType="Journal"><workauthor>Olive, M. F.; Mehmert, K. K.; Koenig, H. N.; Camarini, R.; Kim, J. A.; Nannini, M. A.; Ou, C. J. und Hodge, C. W.</workauthor> (<pubdate>2003</pubdate>): <articletitle>A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient mice</articletitle>, <worktitle>Psychopharmacology (Berl)</worktitle> <volume>165</volume> [<number>2</number>], Seite <pages>181</pages>-<pages>187</pages>. </citation>
<citation id="_bib347" published="yes" workType="Journal"><workauthor>Olivecrona, T.; Chernick, S. S.; Bengtsson-Olivecrona, G.; Paterniti, J. R., Jr.; Brown, W. V. und Scow, R. O.</workauthor> (<pubdate>1985a</pubdate>): <articletitle>Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>260</volume> [<number>4</number>], Seite <pages>2552</pages>-<pages>2557</pages>. </citation>
<citation id="_bib132" published="yes" workType="Journal"><workauthor>Oliveri, Carla; Ocaranza, Maria Paz; Campos, Ximena; Lavandero, Sergio und Jalil, Jorge E.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Angiotensin I-Converting Enzyme Modulates Neutral Endopeptidase Activity in the Rat</articletitle>, <worktitle>Hypertension</worktitle> <volume>38</volume> [<number>3</number>], Seite <pages>650</pages>-<pages>654</pages>. </citation>
<citation id="_bib74" published="yes" workType="Journal"><workauthor>Opazo, C.; Huang, X.; Cherny, R. A.; Moir, R. D.; Roher, A. E.; White, A. R.; Cappai, R.; Masters, C. L.; Tanzi, R. E.; Inestrosa, N. C. und Bush, A. I.</workauthor> (<pubdate>2002b</pubdate>): <articletitle>Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>277</volume> [<number>43</number>], Seite <pages>40302</pages>-<pages>40308</pages>. </citation>
<citation id="_bib378" published="yes" workType="Journal"><workauthor>Ortlepp, J. R.; Breuer, J.; Eitner, F.; Kluge, K.; Kluge, R.; Floege, J.; Hollweg, G.; Hanrath, P. und Joost, H. G.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Inhibition of the renin-angiotensin system ameliorates genetically determined hyperinsulinemia</articletitle>, <worktitle>Eur.J Pharmacol.</worktitle> <volume>436</volume> [<number>1-2</number>], Seite <pages>145</pages>-<pages>150</pages>. </citation>
<citation id="_bib82" published="yes" workType="Journal"><workauthor>Otvos, L., Jr.; Szendrei, G. I.; Lee, V. M. und Mantsch, H. H.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents</articletitle>, <worktitle>Eur.J Biochem</worktitle> <volume>211</volume> [<number>1-2</number>], Seite <pages>249</pages>-<pages>257</pages>. </citation>
<citation id="_bib119" published="yes" workType="Journal"><workauthor>Padovani, A.; Pastorino, L.; Borroni, B.; Colciaghi, F.; Rozzini, L.; Monastero, R.; Perez, J.; Pettenati, C.; Mussi, M.; Parrinello, G.; Cottini, E.; Lenzi, G. L.; Trabucchi, M.; Cattabeni, F. und Di Luca, M.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Amyloid precursor protein in platelets: a peripheral marker for the diagnosis of sporadic AD</articletitle>, <worktitle>Neurology</worktitle> <volume>57</volume> [<number>12</number>], Seite <pages>2243</pages>-<pages>2248</pages>. </citation>
<citation id="_bib331" published="yes" workType="Journal"><workauthor>Panchenko, L. F.; Brusov, O. S. und Beliaev, N. A.</workauthor> (<pubdate>1984b</pubdate>): <articletitle>[Mechanism of action of ethanol on enkephalinase A activity in the rat brain]</articletitle>, <worktitle>Biull.Eksp.Biol Med.</worktitle> <volume>97</volume> [<number>6</number>], Seite <pages>691</pages>-<pages>692</pages>. </citation>
<citation id="_bib255" published="yes" workType="Journal"><workauthor>Papandreou, C. N.; Usmani, B.; Geng, Y.; Bogenrieder, T.; Freeman, R.; Wilk, S.; Finstad, C. L.; Reuter, V. E.; Powell, C. T.; Scheinberg, D.; Magill, C.; Scher, H. I.; Albino, A. P. und Nanus, D. M.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression</articletitle>, <worktitle>Nat Med.</worktitle> <volume>4</volume> [<number>1</number>], Seite <pages>50</pages>-<pages>57</pages>. </citation>
<citation id="_bib411" published="yes" workType="Journal"><workauthor>Perry, T. A. und Greig, N. H.</workauthor> (<pubdate>2004</pubdate>): <articletitle>A new Alzheimer's disease interventive strategy: GLP-1</articletitle>, <worktitle>Curr.Drug Targets.</worktitle> <volume>5</volume> [<number>6</number>], Seite <pages>565</pages>-<pages>571</pages>. </citation>
<citation id="_bib286" published="yes" workType="Journal"><workauthor>Perutz, M. F.; Finch, J. T.; Berriman, J. und Lesk, A.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Amyloid fibers are water-filled nanotubes</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>99</volume> [<number>8</number>], Seite <pages>5591</pages>-<pages>5595</pages>. </citation>
<citation id="_bib356" published="yes" workType="Journal"><workauthor>Phillips, M. S.; Liu, Q.; Hammond, H. A.; Dugan, V.; Hey, P. J.; Caskey, C. J. und Hess, J. F.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Leptin receptor missense mutation in the fatty Zucker rat</articletitle>, <worktitle>Nat.Genet.</worktitle> <volume>13</volume> [<number>1</number>], Seite <pages>18</pages>-<pages>19</pages>. </citation>
<citation id="_bib48" published="yes" workType="Journal"><workauthor>Pitschke, M.; Prior, R.; Haupt, M. und Riesner, D.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy</articletitle>, <worktitle>Nat Med.</worktitle> <volume>4</volume> [<number>7</number>], Seite <pages>832</pages>-<pages>834</pages>. </citation>
<citation id="_bib40" published="yes" workType="Journal"><workauthor>Popov, N.; Pohle, W.; Lossner, B.; Schulzeck, S.; Schmidt, S.; Ott, T. und Matthies, H.</workauthor> (<pubdate>1973</pubdate>): <articletitle>Regional distribution of RNA and protein radioactivity in the rat brain after intraventricular application of labeled precursors</articletitle>, <worktitle>Acta Biol Med.Ger</worktitle> <volume>31</volume> [<number>1</number>], Seite <pages>51</pages>-<pages>62</pages>. </citation>
<citation id="_bib256" published="yes" workType="Journal"><workauthor>Quay, T.; Slaughter, C.; Davis, T. P.; Merrill, B. J. und Hersh, L. B.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Positional effects in the neprilysin (neutral endopeptidase) reaction</articletitle>, <worktitle>Arch.Biochem Biophys.</worktitle> <volume>308</volume> [<number>1</number>], Seite <pages>133</pages>-<pages>136</pages>. </citation>
<citation id="_bib287" published="yes" workType="Journal"><workauthor>Rawlings, N. D. und Barrett, A. J.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Evolutionary families of peptidases</articletitle>, <worktitle>Biochem J</worktitle> <volume>290 ( Pt 1)</volume>, Seite <pages>205</pages>-<pages>218</pages>. </citation>
<citation id="_bib404" published="yes" workType="Journal"><workauthor>Redei, E.; Branch, B. J.; Gholami, S.; Lin, E. Y. und Taylor, A. N.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Effects of ethanol on CRF release in vitro</articletitle>, <worktitle>Endocrinology</worktitle> <volume>123</volume> [<number>6</number>], Seite <pages>2736</pages>-<pages>2743</pages>. </citation>
<citation id="_bib385" published="yes" workType="Journal"><workauthor>Richter, R. M.; Zorrilla, E. P.; Basso, A. M.; Koob, G. F. und Weiss, F.</workauthor> (<pubdate>2000a</pubdate>): <articletitle>Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study</articletitle>, <worktitle>Alcohol Clin Exp Res</worktitle> <volume>24</volume> [<number>12</number>], Seite <pages>1765</pages>-<pages>1772</pages>. </citation>
<citation id="_bib304" published="yes" workType="Journal"><workauthor>Ritchie, J. C.; Davis, T. P. und Nemeroff, C. B.</workauthor> (<pubdate>2003a</pubdate>): <articletitle>Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects</articletitle>, <worktitle>Neuropsychopharmacology</worktitle> <volume>28</volume> [<number>1</number>], Seite <pages>22</pages>-<pages>33</pages>. </citation>
<citation id="_bib403" published="yes" workType="Journal"><workauthor>Rivier, C.; Bruhn, T. und Vale, W.</workauthor> (<pubdate>1984</pubdate>): <articletitle>Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF)</articletitle>, <worktitle>J Pharmacol Exp Ther.</worktitle> <volume>229</volume> [<number>1</number>], Seite <pages>127</pages>-<pages>131</pages>. </citation>
<citation id="_bib348" published="yes" workType="Journal"><workauthor>Riviere, P. J. und Bueno, L.</workauthor> (<pubdate>1987</pubdate>): <articletitle>Origin of the stimulation of food intake by oral administration of enkephalinase inhibitors in sheep</articletitle>, <worktitle>Life Sci.</worktitle> <volume>41</volume> [<number>3</number>], Seite <pages>333</pages>-<pages>339</pages>. </citation>
<citation id="_bib305" published="yes" workType="Journal"><workauthor>Roach, M. K. und Creaven, P. J.</workauthor> (<pubdate>1968</pubdate>): <articletitle>A micro-method for the determination of acetaldehyde and ethanol in blood</articletitle>, <worktitle>Clin Chim.Acta</worktitle> <volume>21</volume> [<number>2</number>], Seite <pages>275</pages>-<pages>278</pages>. </citation>
<citation id="_bib332" published="yes" workType="Journal"><workauthor>Robertson, J. M.; Harding, S. und Grupp, L. A.</workauthor> (<pubdate>1994</pubdate>): <articletitle>The reduction in alcohol intake produced by enalapril is not attenuated by centrally administered angiotensin inhibitors</articletitle>, <worktitle>Alcohol</worktitle> <volume>11</volume> [<number>4</number>], Seite <pages>295</pages>-<pages>299</pages>. </citation>
<citation id="_bib152" published="yes" workType="Journal"><workauthor>Roher, Alex E.; Chaney, Michael O.; Kuo, Yu Min; Webster, Scott D.; Stine, W. Blaine; Haverkamp, Lanny J.; Woods, Amina S.; Cotter, Robert J.; Tuohy, James M.; Krafft, Grant A.; Bonnell, Barry S. und Emmerling, Mark R.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Morphology and Toxicity of Abeta -(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease</articletitle>, <worktitle>Journal of Biological Chemistry</worktitle> <volume>271</volume> [<number>34</number>], Seite <pages>20631</pages>-<pages>20635</pages>. </citation>
<citation id="_bib257" published="yes" workType="Journal"><workauthor>Roques, B. P.; Fournie-Zaluski, M. C.; Soroca, E.; Lecomte, J. M.; Malfroy, B.; Llorens, C. und Schwartz, J. C.</workauthor> (<pubdate>1980</pubdate>): <articletitle>The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice</articletitle>, <worktitle>Nature</worktitle> <volume>288</volume> [<number>5788</number>], Seite <pages>286</pages>-<pages>288</pages>. </citation>
<citation id="_bib221" published="yes" workType="Journal"><workauthor>Roques, B. P.; Noble, F.; Dauge, V.; Fournie-Zaluski, M. C. und Beaumont, A.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology</articletitle>, <worktitle>Pharmacol.Rev.</worktitle> <volume>45</volume> [<number>1</number>], Seite <pages>87</pages>-<pages>146</pages>. </citation>
<citation id="_bib87" published="yes" workType="Journal"><workauthor>Rottkamp, C. A.; Atwood, C. S.; Joseph, J. A.; Nunomura, A.; Perry, G. und Smith, M. A.</workauthor> (<pubdate>2002</pubdate>): <articletitle>The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease</articletitle>, <worktitle>Peptides</worktitle> <volume>23</volume> [<number>7</number>], Seite <pages>1333</pages>-<pages>1341</pages>. </citation>
<citation id="_bib288" published="yes" workType="Journal"><workauthor>Rouleau, J. L.; Pfeffer, M. A.; Stewart, D. J.; Isaac, D.; Sestier, F.; Kerut, E. K.; Porter, C. B.; Proulx, G.; Qian, C. und Block, A. J.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial</articletitle>, <worktitle>Lancet</worktitle> <volume>356</volume> [<number>9230</number>], Seite <pages>615</pages>-<pages>620</pages>. </citation>
<citation id="_bib294" published="yes" workType="Journal"><workauthor>Sahli, S.; Stump, B.; Welti, T.; Blum-Kaelin, D.; Aebi, J. D.; Oefner, C.; Bohm, H. J. und Diederich, F.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Structure-based design, synthesis, and in vitro evaluation of nonpeptidic neprilysin inhibitors</articletitle>, <worktitle>Chembiochem.</worktitle> <volume>5</volume> [<number>7</number>], Seite <pages>996</pages>-<pages>1000</pages>. </citation>
<citation id="_bib401" published="yes" workType="Journal"><workauthor>Saido, T. C.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Aß (1-40) and (1-42) levels in plasma of NEP-KO and wildtype mice.</articletitle>, <worktitle>Persönliche Mitteilung (Email)</worktitle>. </citation>
<citation id="_bib426" published="yes" workType="Journal"><workauthor>Saito, Takashi; Iwata, Nobuhisa; Tsubuki, Satoshi; Takaki, Yoshie; Takano, Jiro; Huang, Shu Ming; Suemoto, Takahiro; Higuchi, Makoto und Saido, Takaomi C.</workauthor> (<pubdate>2005</pubdate>): <articletitle>Somatostatin regulates brain amyloid [beta] peptide A[beta]42 through modulation of proteolytic degradation</articletitle>, <worktitle>Nat Med</worktitle> <volume>11</volume> [<number>4</number>], Seite <pages>434</pages>-<pages>439</pages>. </citation>
<citation id="_bib130" published="yes" workType="Journal"><workauthor>Sakai, A.; Ujike, H.; Nakata, K.; Takehisa, Y.; Imamura, T.; Uchida, N.; Kanzaki, A.; Yamamoto, M.; Fujisawa, Y.; Okumura, K. und Kuroda, S.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease</articletitle>, <worktitle>Dement.Geriatr.Cogn Disord.</worktitle> <volume>17</volume> [<number>3</number>], Seite <pages>164</pages>-<pages>169</pages>. URL: <url href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Citation&amp;list_uids=14739539" type="URL">PM:14739539</url> </citation>
<citation id="_bib306" published="yes" workType="Journal"><workauthor>Sarnyai, Z.; Shaham, Y. und Heinrichs, S. C.</workauthor> (<pubdate>2001</pubdate>): <articletitle>The role of corticotropin-releasing factor in drug addiction</articletitle>, <worktitle>Pharmacol.Rev.</worktitle> <volume>53</volume> [<number>2</number>], Seite <pages>209</pages>-<pages>243</pages>. </citation>
<citation id="_bib379" published="yes" workType="Journal"><workauthor>Schling, P. und Schäfer, T.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Human adipose tissue cells keep tight control on the angiotensin II levels in their vicinity</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>277</volume> [<number>50</number>], Seite <pages>48066</pages>-<pages>48075</pages>. </citation>
<citation id="_bib337" published="yes" workType="Journal"><workauthor>Schneider, R</workauthor> (<pubdate>1996</pubdate>): <articletitle>Relevanz und Kosten der Adipositas in Deutschland</articletitle>, <worktitle>Ernährungs-Umschau</worktitle> <volume>43</volume>, Seite <pages>369</pages>-<pages>374</pages>. </citation>
<citation id="_bib183" published="yes" workType="Journal"><workauthor>Schoeller, Olivia</workauthor> (<pubdate>2004b</pubdate>): <articletitle>Der schlankere Amerikaner</articletitle>, <worktitle>Berliner Zeitung</worktitle>, Seite <pages>1</pages>-<pages>1</pages>. </citation>
<citation id="_bib377" published="yes" workType="Journal"><workauthor>Seidah, N. G.; Benjannet, S.; Hamelin, J.; Mamarbachi, A. M.; Basak, A.; Marcinkiewicz, J.; Mbikay, M.; Chretien, M. und Marcinkiewicz, M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1</articletitle>, <worktitle>Ann.N.Y.Acad.Sci.</worktitle> <volume>885</volume>, Seite <pages>57</pages>-<pages>74</pages>. </citation>
<citation id="_bib107" published="yes" workType="Journal"><workauthor>Selkoe, D. J.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Folding proteins in fatal ways</articletitle>, <worktitle>Nature</worktitle> <volume>426</volume> [<number>6968</number>], Seite <pages>900</pages>-<pages>904</pages>. </citation>
<citation id="_bib108" published="yes" workType="Journal"><workauthor>Selkoe, D. J.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease</articletitle>, <worktitle>J Clin Invest</worktitle> <volume>110</volume> [<number>10</number>], Seite <pages>1375</pages>-<pages>1381</pages>. </citation>
<citation id="_bib111" published="yes" workType="Journal"><workauthor>Selkoe, D. J. und Podlisny, M. B.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Deciphering the genetic basis of Alzheimer's disease</articletitle>, <worktitle>Annu.Rev.Genomics Hum.Genet.</worktitle> <volume>3</volume>, Seite <pages>67</pages>-<pages>99</pages>. </citation>
<citation id="_bib109" published="yes" workType="Journal"><workauthor>Selkoe, D. J. und Schenk, D.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics</articletitle>, <worktitle>Annu.Rev.Pharmacol.Toxicol.</worktitle> <volume>43</volume>, Seite <pages>545</pages>-<pages>584</pages>. </citation>
<citation id="_bib374" published="yes" workType="Journal"><workauthor>Sharma, Arya M.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Is There a Rationale for Angiotensin Blockade in the Management of Obesity Hypertension?</articletitle>, <worktitle>Hypertension</worktitle> <volume>44</volume> [<number>1</number>], Seite <pages>12</pages>-<pages>19</pages>. </citation>
<citation id="_bib258" published="yes" workType="Journal"><workauthor>Shipp, M. A.; Stefano, G. B.; Switzer, S. N.; Griffin, J. D. und Reinherz, E. L.</workauthor> (<pubdate>1991</pubdate>): <articletitle>CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation</articletitle>, <worktitle>Blood</worktitle> <volume>78</volume> [<number>7</number>], Seite <pages>1834</pages>-<pages>1841</pages>. </citation>
<citation id="_bib103" published="yes" workType="Journal"><workauthor>Shirotani, K.; Tsubuki, S.; Iwata, N.; Takaki, Y.; Harigaya, W.; Maruyama, K.; Kiryu-Seo, S.; Kiyama, H.; Iwata, H.; Tomita, T.; Iwatsubo, T. und Saido, T. C.</workauthor> (<pubdate>2001b</pubdate>): <articletitle>Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases</articletitle>, <worktitle>J Biol Chem.</worktitle> <volume>276</volume> [<number>24</number>], Seite <pages>21895</pages>-<pages>21901</pages>. </citation>
<citation id="_bib120" published="yes" workType="Journal"><workauthor>Shoghi-Jadid, K.; Small, G. W.; Agdeppa, E. D.; Kepe, V.; Ercoli, L. M.; Siddarth, P.; Read, S.; Satyamurthy, N.; Petric, A.; Huang, S. C. und Barrio, J. R.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease</articletitle>, <worktitle>Am.J Geriatr.Psychiatry</worktitle> <volume>10</volume> [<number>1</number>], Seite <pages>24</pages>-<pages>35</pages>. </citation>
<citation id="_bib23" published="yes" workType="Journal"><workauthor>Siems, W.; Maul, B.; Krause, W.; Gerard, C.; Hauser, K. F.; Hersh, L. B.; Fischer, H. S.; Zernig, G. und Saria, A.</workauthor> (<pubdate>2000h</pubdate>): <articletitle>Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice</articletitle>, <worktitle>Eur.J.Pharmacol.</worktitle> <volume>397</volume> [<number>2-3</number>], Seite <pages>327</pages>-<pages>334</pages>. </citation>
<citation id="_bib10" published="yes" workType="Journal"><workauthor>Siems, Wolf-Eberhard; Maul, Björn; Wiesner, Burkard; Becker, Matthias; Walther, Thomas; Rothe, L. und Winkler, Anett</workauthor> (<pubdate>2003</pubdate>): <articletitle>Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes</articletitle>, <worktitle>Andrologia</worktitle> <volume>35</volume> [<number>1</number>], Seite <pages>44</pages>-<pages>54</pages>. </citation>
<citation id="_bib216" published="yes" workType="Journal"><workauthor>Sillaber, I.; Rammes, G.; Zimmermann, S.; Mahal, B.; Zieglgansberger, W.; Wurst, W.; Holsboer, F. und Spanagel, R.</workauthor> (<pubdate>2002b</pubdate>): <articletitle>Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors</articletitle>, <worktitle>Science</worktitle> <volume>296</volume> [<number>5569</number>], Seite <pages>931</pages>-<pages>933</pages>. </citation>
<citation id="_bib398" published="yes" workType="Journal"><workauthor>Slawecki, C. J.; Jimenez-Vasquez, P.; Mathe, A. A. und Ehlers, C. L.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats</articletitle>, <worktitle>J.Stud.Alcohol</worktitle> <volume>62</volume> [<number>6</number>], Seite <pages>736</pages>-<pages>740</pages>. </citation>
<citation id="_bib290" published="yes" workType="Journal"><workauthor>Soleilhac, J. M.; Lafuma, C.; Porcher, J. M.; Auburtin, G. und Roques, B. P.</workauthor> (<pubdate>1996a</pubdate>): <articletitle>Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles</articletitle>, <worktitle>Eur.J.Clin.Invest</worktitle> <volume>26</volume> [<number>11</number>], Seite <pages>1011</pages>-<pages>1017</pages>. </citation>
<citation id="_bib189" published="yes" workType="Journal"><workauthor>Solomon, C. G. und Manson, J. E.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Obesity and mortality: a review of the epidemiologic data</articletitle>, <worktitle>Am J Clin Nutr.</worktitle> <volume>66</volume> [<number>4 Suppl</number>], Seite <pages>1044S</pages>-<pages>1050S</pages>. </citation>
<citation id="_bib380" published="yes" workType="Journal"><workauthor>Steinmetz, A.; Fenselau, S. und Schrezenmeir, J.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Treatment of dyslipoproteinemia in the metabolic syndrome</articletitle>, <worktitle>Exp Clin Endocrinol Diabetes</worktitle> <volume>109</volume> [<number>4</number>], Seite <pages>S548</pages>-<pages>S559</pages>. </citation>
<citation id="_bib202" published="yes" workType="Journal"><workauthor>Sturiale, S.; Barbara, G.; Qiu, B.; Figini, M.; Geppetti, P.; Gerard, N.; Gerard, C.; Grady, E. F.; Bunnett, N. W. und Collins, S. M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>96</volume> [<number>20</number>], Seite <pages>11653</pages>-<pages>11658</pages>. </citation>
<citation id="_bib333" published="yes" workType="Journal"><workauthor>Szczepanska, R. und Grupp, L. A.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Bestatin, an aminopeptidase B inhibitor, selectively reduces alcohol intake in rats</articletitle>, <worktitle>Alcohol Clin Exp Res</worktitle> <volume>17</volume> [<number>2</number>], Seite <pages>434</pages>-<pages>437</pages>. </citation>
<citation id="_bib335" published="yes" workType="Journal"><workauthor>Szczepanska, R.; Harding, S. und Grupp, L. A.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Effect of bestatin, an aminopeptidase inhibitor, on alcohol intake in alcohol-preferring P rats</articletitle>, <worktitle>Alcohol Clin Exp Res</worktitle> <volume>20</volume> [<number>3</number>], Seite <pages>561</pages>-<pages>565</pages>. </citation>
<citation id="_bib13" published="yes" workType="Journal"><workauthor>Takaki, Y.; Iwata, N.; Tsubuki, S.; Taniguchi, S.; Toyoshima, S.; Lu, B.; Gerard, N. P.; Gerard, C.; Lee, H. J.; Shirotani, K. und Saido, T. C.</workauthor> (<pubdate>2000a</pubdate>): <articletitle>Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain</articletitle>, <worktitle>Journal of Biochemistry</worktitle> <volume>128</volume> [<number>6</number>], Seite <pages>897</pages>-<pages>902</pages>. </citation>
<citation id="_bib232" published="yes" workType="Journal"><workauthor>Tam, L. T.; Engelbrecht, S.; Talent, J. M.; Gracy, R. W. und Erdos, E. G.</workauthor> (<pubdate>1985</pubdate>): <articletitle>The importance of disulfide bridges in human endopeptidase (enkephalinase) after proteolytic cleavage</articletitle>, <worktitle>Biochem Biophys.Res Commun.</worktitle> <volume>133</volume> [<number>3</number>], Seite <pages>1187</pages>-<pages>1192</pages>. </citation>
<citation id="_bib311" published="yes" workType="Journal"><workauthor>The Protein Data Bank</workauthor> (<pubdate>2004</pubdate>): <articletitle>1DMT</articletitle>, <url href="http://www.rcsb.org/pdb/cgi/explore.cgi?pid=94401132867010&amp;pdbId=1DMT" type="URL">http://www.rcsb.org/pdb/cgi/explore.cgi?pid=94401132867010&amp;pdbId=1DMT</url>. </citation>
<citation id="_bib418" published="yes" workType="Journal"><workauthor>Thiele, Todd E.; Navarro, Montserrat; Sparta, Dennis R.; Fee, Jon R.; Knapp, Darin J. und Cubero, Inmaculada</workauthor> (<pubdate>2003</pubdate>): <articletitle>Alcoholism and obesity: overlapping neuropeptide pathways?</articletitle>, <worktitle>Neuropeptides</worktitle> <volume>37</volume> [<number>6</number>], Seite <pages>321</pages>-<pages>337</pages>. </citation>
<citation id="_bib215" published="yes" workType="Journal"><workauthor>Timpl, P.; Spanagel, R.; Sillaber, I.; Kresse, A.; Reul, J. M.; Stalla, G. K.; Blanquet, V.; Steckler, T.; Holsboer, F. und Wurst, W.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1</articletitle>, <worktitle>Nat Genet.</worktitle> <volume>19</volume> [<number>2</number>], Seite <pages>162</pages>-<pages>166</pages>. </citation>
<citation id="_bib391" published="yes" workType="Journal"><workauthor>Toyoda, M.; Nakamura, M.; Makino, T.; Kagoura, M. und Morohashi, M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Sebaceous glands in acne patients express high levels of neutral endopeptidase</articletitle>, <worktitle>Exp Dermatol.</worktitle> <volume>11</volume> [<number>3</number>], Seite <pages>241</pages>-<pages>247</pages>. </citation>
<citation id="_bib310" published="yes" workType="Journal"><workauthor>Tsubuki, S.; Takaki, Y. und Saido, T. C.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation</articletitle>, <worktitle>Lancet</worktitle> <volume>361</volume> [<number>9373</number>], Seite <pages>1957</pages>-<pages>1958</pages>. </citation>
<citation id="_bib236" published="yes" workType="Journal"><workauthor>Turner, A. J.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries</articletitle>, <worktitle>Biochem Soc Trans</worktitle> <volume>31</volume> [<number>Pt 3</number>], Seite <pages>723</pages>-<pages>727</pages>. </citation>
<citation id="_bib289" published="yes" workType="Book"><workauthor>Turner, A. J.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Neprilysin</articletitle>, <editor>Barrett, A. J.; Rawlings, N. D. und Woessner, j. f.</editor>, <worktitle>Handbook of proteolytic enzymes</worktitle> , Seite <pages>1080</pages>-<pages>1085</pages>, <publisher>Academic Press</publisher>, <address>San Diego</address>. </citation>
<citation id="_bib58" published="yes" workType="Journal"><workauthor>Vassar, R. und Citron, M.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Abeta-generating enzymes: recent advances in beta- and gamma-secretase research</articletitle>, <worktitle>Neuron</worktitle> <volume>27</volume> [<number>3</number>], Seite <pages>419</pages>-<pages>422</pages>. </citation>
<citation id="_bib81" published="yes" workType="Journal"><workauthor>Vaughan, D. W. und Peters, A.</workauthor> (<pubdate>1981</pubdate>): <articletitle>The structure of neuritic plaque in the cerebral cortex of aged rats</articletitle>, <worktitle>J Neuropathol.Exp Neurol.</worktitle> <volume>40</volume> [<number>4</number>], Seite <pages>472</pages>-<pages>487</pages>. </citation>
<citation id="_bib27" published="yes" workType="Journal"><workauthor>Vekrellis, Konstantinos; Ye, Zhen; Qiu, Wei Qiao; Walsh, Dominic; Hartley, Dean; Chesneau, Valerie; Rosner, Marsha Rich und Selkoe, Dennis J.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Neurons Regulate Extracellular Levels of Amyloid beta -Protein via Proteolysis by Insulin-Degrading Enzyme</articletitle>, <worktitle>Journal of Neuroscience</worktitle> <volume>20</volume> [<number>5</number>], Seite <pages>1657</pages>-<pages>1665</pages>. </citation>
<citation id="_bib297" published="yes" workType="Journal"><workauthor>Waksman, G.; Hamel, E.; Fournie-Zaluski, M. C. und Roques, B. P.</workauthor> (<pubdate>1986</pubdate>): <articletitle>Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>83</volume> [<number>5</number>], Seite <pages>1523</pages>-<pages>1527</pages>. </citation>
<citation id="_bib419" published="yes" workType="Journal"><workauthor>Wallenius, Ville; Wallenius, Kristina; Ahrén, Bo; Rudling, Mats; Carlsten, Hans; Dickson, Suzanne L.; Ohlsson, Claes und Jansson, John-Olov</workauthor> (<pubdate>2005</pubdate>): <articletitle>Interleukin-6-deficient mice develop mature-onset obesity</articletitle>, <worktitle>Nature Medicine</worktitle> <volume>8</volume>, Seite <pages>75</pages>-<pages>79</pages>. </citation>
<citation id="_bib32" published="yes" workType="Journal"><workauthor>Walsh, D. M.; Klyubin, I.; Fadeeva, J. V.; Cullen, W. K.; Anwyl, R.; Wolfe, M. S.; Rowan, M. J. und Selkoe, D. J.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo</articletitle>, <worktitle>Nature</worktitle> <volume>416</volume> [<number>6880</number>], Seite <pages>535</pages>-<pages>539</pages>. </citation>
<citation id="_bib433" published="yes" workType="Journal"><workauthor>Walther, T.; Albrecht, D.; Becker, A.; Becker, M.; Schubert, M.; Maul, B.; Stoltenburg, G.; Schultheiss, H. P.; Grecksch, G. und Siems, W. E.</workauthor> (<pubdate>2005</pubdate>): <articletitle>Janus-head neutral endopeptidase (NEP) - Improved learning and memory in old-aged mice that are deficient in the amyloid-ß-degrading peptidase NEP.</articletitle>, <worktitle>In Vorbereitung</worktitle>. </citation>
<citation id="_bib12" published="yes" workType="Journal"><workauthor>Walther, T.; Stepan, H.; Pankow, K.; Becker, M.; Schultheiss, H. P. und Siems, W. E.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide</articletitle>, <worktitle>Biol.Chem.</worktitle> <volume>385</volume> [<number>2</number>], Seite <pages>179</pages>-<pages>184</pages>. </citation>
<citation id="_bib121" published="yes" workType="Journal"><workauthor>Wengenack, T. M.; Curran, G. L. und Poduslo, J. F.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Targeting alzheimer amyloid plaques in vivo</articletitle>, <worktitle>Nat Biotechnol.</worktitle> <volume>18</volume> [<number>8</number>], Seite <pages>868</pages>-<pages>872</pages>. </citation>
<citation id="_bib219" published="yes" workType="Journal"><workauthor>Wick, M. J.; Mihic, S. J.; Ueno, S.; Mascia, M. P.; Trudell, J. R.; Brozowski, S. J.; Ye, Q.; Harrison, N. L. und Harris, R. A.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>95</volume> [<number>11</number>], Seite <pages>6504</pages>-<pages>6509</pages>. </citation>
<citation id="_bib8" published="yes" workType="Journal"><workauthor>Winkler, Anett; Rottmann, Matthias; Heder, Gottfried; Hyytiä, Petri; Siems, Wolf-Eberhard und Melzig, Matthias F.</workauthor> (<pubdate>1998b</pubdate>): <articletitle>Gene expression and activity of specific opioid-degrading enzymes in different brain regions of the AA and ANA lines of rats</articletitle>, <worktitle>Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease</worktitle> <volume>1406</volume> [<number>3</number>], Seite <pages>219</pages>-<pages>227</pages>. </citation>
<citation id="_bib193" published="yes" workType="Journal"><workauthor>Wong-Leung, Y. L. und Kenny, A. J.</workauthor> (<pubdate>1968</pubdate>): <articletitle>Some properties of a microsomal peptidase in rat kidney</articletitle>, <worktitle>Biochem J</worktitle> <volume>110</volume> [<number>2</number>], Seite <pages>5P</pages>. </citation>
<citation id="_bib278" published="yes" workType="Journal"><workauthor>Yamaguchi, T.; Fukase, M.; Arao, M.; Sugimoto, T. und Chihara, K.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Endothelin 1 hydrolysis by rat kidney membranes</articletitle>, <worktitle>FEBS Lett.</worktitle> <volume>309</volume> [<number>3</number>], Seite <pages>303</pages>-<pages>306</pages>. </citation>
<citation id="_bib73" published="yes" workType="Journal"><workauthor>Yang, D. S.; McLaurin, J.; Qin, K.; Westaway, D. und Fraser, P. E.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Examining the zinc binding site of the amyloid-beta peptide</articletitle>, <worktitle>Eur.J Biochem</worktitle> <volume>267</volume> [<number>22</number>], Seite <pages>6692</pages>-<pages>6698</pages>. </citation>
<citation id="_bib97" published="yes" workType="Journal"><workauthor>Yasojima, K.; Akiyama, H.; McGeer, E. G. und McGeer, P. L.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide</articletitle>, <worktitle>Neurosci.Lett.</worktitle> <volume>297</volume> [<number>2</number>], Seite <pages>97</pages>-<pages>100</pages>. </citation>
<citation id="_bib96" published="yes" workType="Journal"><workauthor>Yasojima, K.; McGeer, E. G. und McGeer, P. L.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain</articletitle>, <worktitle>Brain Res</worktitle> <volume>919</volume> [<number>1</number>], Seite <pages>115</pages>-<pages>121</pages>. </citation>
<citation id="_bib54" published="yes" workType="Journal"><workauthor>Yu, G.; Nishimura, M.; Arawaka, S.; Levitan, D.; Zhang, L.; Tandon, A.; Song, Y. Q.; Rogaeva, E.; Chen, F.; Kawarai, T.; Supala, A.; Levesque, L.; Yu, H.; Yang, D. S.; Holmes, E.; Milman, P.; Liang, Y.; Zhang, D. M.; Xu, D. H.; Sato, C.; Rogaev, E.; Smith, M.; Janus, C.; Zhang, Y.; Aebersold, R.; Farrer, L. S.; Sorbi, S.; Bruni, A.; Fraser, P. und George-Hyslop, P.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing</articletitle>, <worktitle>Nature</worktitle> <volume>407</volume> [<number>6800</number>], Seite <pages>48</pages>-<pages>54</pages>. </citation>
<citation id="_bib240" published="yes" workType="Journal"><workauthor>Zhang, Y.; Proenca, R.; Maffei, M.; Barone, M.; Leopold, L. und Friedman, J. M.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Positional cloning of the mouse obese gene and its human homologue</articletitle>, <worktitle>Nature</worktitle> <volume>372</volume> [<number>6505</number>], Seite <pages>425</pages>-<pages>432</pages>. </citation>
<citation id="_bib376" published="yes" workType="Journal"><workauthor>Zhu, X.; Zhou, A.; Dey, A.; Norrbom, C.; Carroll, R.; Zhang, C.; Laurent, V.; Lindberg, I.; Ugleholdt, R.; Holst, J. J. und Steiner, D. F.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>99</volume> [<number>16</number>], Seite <pages>10293</pages>-<pages>10298</pages>. </citation>
         </p>
      </bibliography></cms:content></cms:document></cms:container>