Abkürzungsverzeichnis

ADP

Adenosin-5’-diphosphat

AIP4

Atrophin-1-interacting protein 4

AMP

Adenosin-5’-monophosphat

Amp

Ampicillin

AP-1

Activating protein 1

AP-2

Activating protein 2

APS

Ammoniumpersulfat

ASV 17

Avian sarcoma virus 17

ATF

Activating transcription factor

ATP

Adenosin-5’-triphosphat

Bcl

B cell lymphoma/leukemia

bHLH

Basic helix-loop-helix

BSA

Bovine serum albumine

bZIP

Basische Leuzinzipper

c

Cellular

cAMP

Cyclic AMP

CBP

CREB binding protein

CD

Cluster of differentiation

CDK

Cyclin-dependent kinase

CDKI

CDK-Inhibitor

CK2

Caseinkinase II (alter Name der Proteinkinase CK2)

COP

Constitutive photomorphogenesis

CRE

cAMP response element

CREB

cAMP response elements-binding protein

CSN

COP9-Signalosom

DCX

DDB1/Cul4A/X-box

DDB1

UV-damaged DNA-binding protein 1

DET1

De-etiolated-1

DMSO

Dimethylsulfoxid

DNA

Deoxyribonucleic acid

DRB

5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazol

DTT

Dithiothreitol

DUB

Deubiquitinating enzyme (=USP)

E1

Enzym 1 = Ubiquitin-aktivierendes Enzym

E2

Enzym 2 = Ubiquitin-konjugierendes Enzym

E2F

E2 promoter binding factor

E3

Enzym 3 = Ubiquitinligase

ECL

Enhanced chemiluminescence

EDTA

Ethylendiamintetraessigsäure

E. coli

Escherichia coli

EGF

Epidermal growth factor

EGFR

EGF receptor

EG-VEGF

Endocrine gland-derived VEGF

ELISA

Enzyme linked immunosorbent assay

ERK

Extracellular signal-regulated kinase

Fas

Fibroblast associated

FasL

Fas-Ligand

FCS

Fetal calf serum

FDA

Food and Drug Administration

FGF

Fibroblast growth factor

Flk-1

Fetal liver kinase-1

Flt-1

FMS-like thyrosine kinase-1

GG

Glycerolgradient

GM-CSF

Granulocyte-macrophage colony-stimulating factor

GST

Glutathion-S-Transferase

h

Human

HB-EGF

Heparin-binding epidermal growth factor

HECT

Homologous to the E6-AP carboxyl terminus

HER2

Human epidermal growth factor receptor 2

HIF-1

Hypoxia-inducible factor 1

His

Histidin

His-Ub

His10-markiertes Ubiquitin

HLH

Helix-loop-helix

HMW

High molecular weight

Hsp90

Heat shock protein 90

HY5

Long hypocotyl 5

ICSBP

Interferon consensus sequence-binding protein

Id

Inhibitor of DNA binding / inhibitor of differentiation

IGF-1

Insulin-like growth factor 1

IκBα

NF-κB inhibitor α

IL

Interleukin

IP

Immunpräzipitation

IP-5/6-Kinase

Inositol-1,3,5-trisphosphat-5/6-Kinase

JAB1

Jun activation domain-binding protein 1

JAMM

JAB1/MPN domain metalloenzyme

JNK

Jun N-terminal kinase

KDR

Kinase domain region

KGF

Keratinocyte growth factor

LB

Luria Bertani

Leu

Leuzin

Lys

Lysin

Maf

Musculoaponeurotic fibrosarcoma

MAP

Mitogen-activated protein

MAPK

MAP kinase

MAPKK

MAPK kinase

Mdm2

Murine double minute clone 2

MEF2c

Monocyte-specific enhancer binder factor 2c

MG-132

Z-Leu-Leu-Leu-H

MMP

Matrix metalloproteinase

MOPS

3-N-Morpholinopropansulfonsäure

MPN

Mpr1/Pad1/N-terminal

mRNA

Messenger RNA

NEDD8

Neural precursor cell expressed,
developmentally down-regulated 8

NES

Nuclear export sequence

NF-κB

Nuclear factor κB

NLS

Nuclear localization sequence

NP-40

Nonidet P-40

OD

Optische Dichte

p53

Protein 53 kDa

PA700

Proteasom-Aktivator 700 kDa

PAGE

Polyacrylamid-Gelelektrophorese

PBS

Phosphate buffered saline

PBST

PBS + 0,1% Tween-20

PDGF

Platelet-derived growth factor

PKA

cAMP-abhängige Proteinkinase A

PKC

Proteinkinase C

PKD

Proteinkinase D

PMSF

Phenylmethylsulfonylfluorid

pRB

Retinoblastoma protein

psi

Pounds per square inch

RING

Really interesting new gene

RIPA

Radio-immunoprecipitation assay

RNA

Ribonucleic acid

ROC1

Regulator of cullins-1

rpm

Revolutions per minute

RPMI

Roswell Park Memorial Institute

S

Svedberg-Koeffizient

SAP-1

Stomach cancer-associated protein tyrosine phosphatase-1

SCF

Skp1/Cul1/F-box-protein

SDS

Sodium dodecyl sulphate

Ser

Serin

SP-1

Specificity protein 1

TAE

Tris/Acetat/EDTA

TAF

Tumour angiogenesis factor

TCA

Trichloressigsäure

TCF

Ternary complex factor

TEMED

N,N,N',N'-Tetramethyl-p-Phenylendiamin

Thr

Threonin

TGF-β

Transforming growth factor β

TIMP

Tissue inhibitor of metalloproteinases

TNF-α

Tumour necrosis factor α

TPA

Phorbol 12-O-tetradecanoate-13-acetate

TRE

TPA response element

TRIP15

Thyroid-hormone-receptor-interacting protein 15

Tris

Tris-Hydroxymethylaminomethan

Ub

Ubiquitin

Ub n

Polyubiquitin

Ubp

Ubiquitin -binding protein

uPA

Urokinase plasminogen activator

uPAR

uPA receptor

USP

Ubiquitin-specific protease / Ubiquitin-Isopeptidase

UV

Ultraviolett

v

Viral

VEGF

Vascular endothelial growth factor

VEGFR

VEGF receptor

VPF

Vascular permeability factor


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