<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">"Der Einfluß von Batimastat auf Prostatakarzinom Zellinien und den Dunning Tumor der Ratte"</cms:entry><cms:entry type="author">Dietmar Borchert</cms:entry><cms:entry type="author"/><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="N10059" part="chapter1" ref="N10059" type="pagenumber">1</cms:entry><cms:entry id="N1005E" part="chapter1" ref="N1005E" type="section">1.1</cms:entry><cms:entry id="N10067" part="chapter1" ref="N10067" type="section">1.2</cms:entry><cms:entry id="N1006C" part="chapter1" ref="N1006C" type="subsection">1.2.1</cms:entry><cms:entry id="N10073" part="chapter1" ref="N10073" type="pagenumber">2</cms:entry><cms:entry id="N10079" part="chapter1" ref="N10079" type="subsection">1.2.2</cms:entry><cms:entry id="N10080" part="chapter1" ref="N10080" type="pagenumber">3</cms:entry><cms:entry id="N10086" part="chapter1" ref="N10086" type="subsection">1.2.3</cms:entry><cms:entry id="N1008F" part="chapter1" ref="N1008F" type="subsection">1.2.4</cms:entry><cms:entry id="N10093" part="chapter1" ref="N10093" type="pagenumber">4</cms:entry><cms:entry id="N100A0" part="chapter1" ref="N100A0" type="pagenumber">5</cms:entry><cms:entry id="N100A6" part="chapter1" ref="N100A6" type="subsection">1.2.5</cms:entry><cms:entry id="N100B3" part="chapter1" ref="N100B3" type="section">1.3</cms:entry><cms:entry id="N100B7" part="chapter1" ref="N100B7" type="pagenumber">6</cms:entry><cms:entry id="N100BC" part="chapter1" ref="N100BC" type="subsection">1.3.1</cms:entry><cms:entry id="N100C6" part="chapter1" ref="N100C6" type="pagenumber">7</cms:entry><cms:entry id="N100D0" part="chapter1" ref="N100D0" type="pagenumber">8</cms:entry><cms:entry id="N100D6" part="chapter1" ref="N100D6" type="subsection">1.3.2</cms:entry><cms:entry id="N100FF" part="chapter1" ref="N100FF" type="pagenumber">9</cms:entry><cms:entry id="N10108" part="chapter1" ref="N10108" type="subsection">1.3.3</cms:entry><cms:entry id="N1010C" part="chapter1" ref="N1010C" type="pagenumber">10</cms:entry><cms:entry id="N1011B" part="chapter1" ref="N1011B" type="pagenumber">11</cms:entry><cms:entry id="N10122" part="chapter1" ref="N10122" type="section">1.4</cms:entry><cms:entry id="N10127" part="chapter1" ref="N10127" type="subsection">1.4.1</cms:entry><cms:entry id="N1012E" part="chapter1" ref="N1012E" type="pagenumber">12</cms:entry><cms:entry id="N10134" part="chapter1" ref="N10134" type="subsection">1.4.2</cms:entry><cms:entry id="N1013B" part="chapter1" ref="N1013B" type="pagenumber">13</cms:entry><cms:entry id="N10141" part="chapter1" ref="N10141" type="subsection">1.4.3</cms:entry><cms:entry id="N1014B" part="chapter1" ref="N1014B" type="pagenumber">14</cms:entry><cms:entry id="N10151" part="chapter1" ref="N10151" type="subsection">1.4.4</cms:entry><cms:entry id="N1015B" part="chapter1" ref="N1015B" type="section">1.5</cms:entry><cms:entry id="N1015F" part="chapter1" ref="N1015F" type="pagenumber">15</cms:entry><cms:entry id="N10164" part="chapter1" ref="N10164" type="subsection">1.5.1</cms:entry><cms:entry id="N1016D" part="chapter1" ref="N1016D" type="subsection">1.5.2</cms:entry><cms:entry id="N10174" part="chapter1" ref="N10174" type="pagenumber">16</cms:entry><cms:entry id="N1017B" part="chapter1" ref="N1017B" type="section">1.6</cms:entry><cms:entry id="N10180" part="chapter1" ref="N10180" type="subsection">1.6.1</cms:entry><cms:entry id="N10187" part="chapter1" ref="N10187" type="pagenumber">17</cms:entry><cms:entry id="N1018D" part="chapter1" ref="N1018D" type="subsection">1.6.2</cms:entry><cms:entry id="N10197" part="chapter1" ref="N10197" type="pagenumber">18</cms:entry><cms:entry id="N1019B" part="chapter1" ref="N1019B" type="mm">585#349</cms:entry><cms:entry id="N101A1" part="chapter1" ref="N101A1" type="subsection">1.6.3</cms:entry><cms:entry id="N101AB" part="chapter1" ref="N101AB" type="pagenumber">19</cms:entry><cms:entry id="N101B2" part="chapter1" ref="N101B2" type="section">1.7</cms:entry><cms:entry id="N101B7" part="chapter1" ref="N101B7" type="subsection">1.7.1</cms:entry><cms:entry id="N101C1" part="chapter1" ref="N101C1" type="pagenumber">20</cms:entry><cms:entry id="N101D6" part="chapter1" ref="N101D6" type="subsection">1.7.2</cms:entry><cms:entry id="N101DA" part="chapter1" ref="N101DA" type="pagenumber">21</cms:entry><cms:entry id="N101E9" part="chapter1" ref="N101E9" type="pagenumber">22</cms:entry><cms:entry id="N101EF" part="chapter1" ref="N101EF" type="subsection">1.7.3</cms:entry><cms:entry id="N101F8" part="chapter1" ref="N101F8" type="pagenumber">23</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10204" part="chapter2" ref="N10204" type="pagenumber">24</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N10224" part="chapter3" ref="N10224" type="pagenumber">25</cms:entry><cms:entry id="N10229" part="chapter3" ref="N10229" type="section">3.1</cms:entry><cms:entry id="N10232" part="chapter3" ref="N10232" type="section">3.2</cms:entry><cms:entry id="N1023B" part="chapter3" ref="N1023B" type="section">3.3</cms:entry><cms:entry id="N10246" part="chapter3" ref="N10246" type="section">3.4</cms:entry><cms:entry id="N1024A" part="chapter3" ref="N1024A" type="pagenumber">26</cms:entry><cms:entry id="N10253" part="chapter3" ref="N10253" type="section">3.5</cms:entry><cms:entry id="N1025C" part="chapter3" ref="N1025C" type="section">3.6</cms:entry><cms:entry id="N10263" part="chapter3" ref="N10263" type="pagenumber">27</cms:entry><cms:entry id="N10285" part="chapter3" ref="N10285" type="section">3.7</cms:entry><cms:entry id="N10289" 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type="link"/><cms:entry id="_1093097342" part="chapter4" ref="_1093097342" type="link"/><cms:entry id="_1093185992" part="chapter4" ref="_1093185992" type="link"/><cms:entry id="_1143231061" part="chapter4" ref="_1143231061" type="link"/><cms:entry id="_1144309063" part="chapter4" ref="_1144309063" type="link"/><cms:entry id="_1149667696" part="chapter4" ref="_1149667696" type="link"/><cms:entry id="N102E1" part="chapter4" ref="N102E1" type="mm">439#292</cms:entry><cms:entry id="N102EC" part="chapter4" ref="N102EC" type="pagenumber">31</cms:entry><cms:entry id="_1139408377" part="chapter4" ref="_1139408377" type="link"/><cms:entry id="_1144309124" part="chapter4" ref="_1144309124" type="link"/><cms:entry id="_1149667698" part="chapter4" ref="_1149667698" type="link"/><cms:entry id="N10301" part="chapter4" ref="N10301" type="mm">439#287</cms:entry><cms:entry id="N1030C" part="chapter4" ref="N1030C" type="pagenumber">32</cms:entry><cms:entry id="_1139408267" part="chapter4" ref="_1139408267" type="link"/><cms:entry id="_1139408310" part="chapter4" ref="_1139408310" type="link"/><cms:entry id="_1144309034" part="chapter4" ref="_1144309034" type="link"/><cms:entry id="_1149667699" part="chapter4" ref="_1149667699" type="link"/><cms:entry id="N10322" part="chapter4" ref="N10322" type="mm">439#287</cms:entry><cms:entry id="N1032C" part="chapter4" ref="N1032C" type="section">4.2</cms:entry><cms:entry id="N10330" part="chapter4" ref="N10330" type="pagenumber">33</cms:entry><cms:entry id="_1092825155" part="chapter4" ref="_1092825155" type="link"/><cms:entry id="_1096364453" part="chapter4" ref="_1096364453" type="link"/><cms:entry id="_1149667700" part="chapter4" ref="_1149667700" type="link"/><cms:entry id="N10343" part="chapter4" ref="N10343" type="mm">429#289</cms:entry><cms:entry id="N10350" part="chapter4" ref="N10350" type="pagenumber">34</cms:entry><cms:entry id="N1035D" part="chapter4" ref="N1035D" type="pagenumber">35</cms:entry><cms:entry id="_1139408418" part="chapter4" ref="_1139408418" type="link"/><cms:entry id="_1144309183" part="chapter4" ref="_1144309183" type="link"/><cms:entry id="_1144309735" part="chapter4" ref="_1144309735" type="link"/><cms:entry id="_1148471657" part="chapter4" ref="_1148471657" type="link"/><cms:entry id="_1148471701" part="chapter4" ref="_1148471701" type="link"/><cms:entry id="_1149667702" part="chapter4" ref="_1149667702" type="link"/><cms:entry id="N10373" part="chapter4" ref="N10373" type="mm">604#652</cms:entry><cms:entry id="N1037E" part="chapter4" ref="N1037E" type="pagenumber">36</cms:entry><cms:entry id="_1139408456" part="chapter4" ref="_1139408456" type="link"/><cms:entry id="_1144309658" part="chapter4" ref="_1144309658" type="link"/><cms:entry id="_1148472285" part="chapter4" ref="_1148472285" type="link"/><cms:entry id="_1149667704" part="chapter4" ref="_1149667704" type="link"/><cms:entry id="N1038E" part="chapter4" ref="N1038E" type="mm">604#662</cms:entry><cms:entry 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type="mm">517#353</cms:entry><cms:entry id="N10729" part="chapter4" ref="N10729" type="pagenumber">43</cms:entry><cms:entry id="N10730" part="chapter4" ref="N10730" type="mm">516#319</cms:entry><cms:entry id="N1073B" part="chapter4" ref="N1073B" type="pagenumber">44</cms:entry><cms:entry id="_1150026217" part="chapter4" ref="_1150026217" type="link"/><cms:entry id="N10745" part="chapter4" ref="N10745" type="mm">524#319</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N10757" part="chapter5" ref="N10757" type="pagenumber">45</cms:entry><cms:entry id="N1075C" part="chapter5" ref="N1075C" type="section">5.1</cms:entry><cms:entry id="N10769" part="chapter5" ref="N10769" type="pagenumber">46</cms:entry><cms:entry id="N1076F" part="chapter5" ref="N1076F" type="section">5.2</cms:entry><cms:entry id="N10776" part="chapter5" ref="N10776" type="pagenumber">47</cms:entry><cms:entry id="N10783" part="chapter5" ref="N10783" type="pagenumber">48</cms:entry><cms:entry id="N1078C" part="chapter5" ref="N1078C" type="section">5.3</cms:entry><cms:entry id="N10796" part="chapter5" ref="N10796" type="pagenumber">49</cms:entry><cms:entry id="N107A1" part="chapter5" ref="N107A1" type="subsection">5.3.1</cms:entry><cms:entry id="N107A5" part="chapter5" ref="N107A5" type="pagenumber">50</cms:entry><cms:entry id="N107B5" part="chapter5" ref="N107B5" type="pagenumber">51</cms:entry><cms:entry id="N107C1" part="chapter5" ref="N107C1" type="pagenumber">52</cms:entry><cms:entry id="N107C8" part="chapter5" ref="N107C8" type="section">5.4</cms:entry><cms:entry id="N107D5" part="chapter5" ref="N107D5" type="pagenumber">53</cms:entry><cms:entry id="N107DA" part="chapter5" ref="N107DA" type="subsection">5.4.1</cms:entry><cms:entry id="N107E4" part="chapter5" ref="N107E4" type="pagenumber">54</cms:entry><cms:entry id="N107F1" part="chapter5" ref="N107F1" type="pagenumber">55</cms:entry><cms:entry id="N107FA" part="chapter5" ref="N107FA" type="subsection">5.4.2</cms:entry><cms:entry id="N10801" part="chapter5" ref="N10801" type="pagenumber">56</cms:entry><cms:entry id="N10807" part="chapter5" ref="N10807" type="subsection">5.4.3</cms:entry><cms:entry id="N10811" part="chapter5" ref="N10811" type="pagenumber">57</cms:entry><cms:entry id="N1081B" part="chapter5" ref="N1081B" type="pagenumber">58</cms:entry><cms:entry id="N10821" part="chapter5" ref="N10821" type="subsection">5.4.4</cms:entry><cms:entry id="N1082B" part="chapter5" ref="N1082B" type="pagenumber">59</cms:entry><cms:entry id="N10837" part="chapter5" ref="N10837" type="subsection">5.4.5</cms:entry><cms:entry id="N1083E" part="chapter5" ref="N1083E" type="pagenumber">60</cms:entry><cms:entry id="N10848" part="chapter5" ref="N10848" type="pagenumber">61</cms:entry><cms:entry id="N1084F" part="chapter5" ref="N1084F" type="pagenumber">62</cms:entry><cms:entry id="N10855" part="chapter5" ref="N10855" type="subsection">5.4.6</cms:entry><cms:entry id="N10861" part="chapter5" ref="N10861" type="pagenumber">63</cms:entry><cms:entry id="N1086B" part="chapter5" ref="N1086B" type="pagenumber">64</cms:entry><cms:entry ref="N1087A" type="back"/><cms:entry id="N1087C" part="N1087C" ref="N1087C" type="abbreviation">Abkürzungsverzeichnis</cms:entry><cms:entry id="N10883" part="N1087C" ref="N10883" type="table"/><cms:entry id="N10A92" part="N1087C" ref="N10A92" type="pagenumber">VI</cms:entry><cms:entry ref="N10AE6" type="bibliography">
				
				Literaturverzeichnis</cms:entry><cms:entry ref="RMRefList_Lein_14" type="link"/><cms:entry ref="N10AED" type="pagenumber">65</cms:entry><cms:entry ref="_bib1" type="citation"/><cms:entry ref="_bib2" type="citation"/><cms:entry ref="_bib3" type="citation"/><cms:entry ref="_bib4" type="citation"/><cms:entry ref="_bib5" type="citation"/><cms:entry ref="_bib6" type="citation"/><cms:entry ref="_bib7" type="citation"/><cms:entry ref="_bib8" type="citation"/><cms:entry ref="_bib9" type="citation"/><cms:entry ref="_bib10" type="citation"/><cms:entry ref="_bib11" type="citation"/><cms:entry ref="_bib12" type="citation"/><cms:entry ref="_bib13" type="citation"/><cms:entry ref="_bib14" type="citation"/><cms:entry ref="_bib15" type="citation"/><cms:entry ref="_bib16" type="citation"/><cms:entry ref="_bib17" type="citation"/><cms:entry ref="_bib18" type="citation"/><cms:entry ref="_bib19" type="citation"/><cms:entry ref="_bib20" type="citation"/><cms:entry ref="_bib21" type="citation"/><cms:entry ref="_bib22" type="citation"/><cms:entry ref="_bib23" type="citation"/><cms:entry ref="_bib24" type="citation"/><cms:entry ref="_bib25" type="citation"/><cms:entry ref="_bib26" type="citation"/><cms:entry ref="_bib27" type="citation"/><cms:entry ref="_bib28" type="citation"/><cms:entry ref="_bib29" type="citation"/><cms:entry ref="_bib30" type="citation"/><cms:entry ref="_bib31" type="citation"/><cms:entry ref="_bib32" type="citation"/><cms:entry ref="_bib33" type="citation"/><cms:entry ref="_bib34" type="citation"/><cms:entry ref="_bib35" type="citation"/><cms:entry ref="_bib36" type="citation"/><cms:entry ref="_bib37" type="citation"/><cms:entry ref="_bib38" type="citation"/><cms:entry ref="_bib39" type="citation"/><cms:entry ref="_bib40" type="citation"/><cms:entry ref="_bib41" type="citation"/><cms:entry ref="_bib42" type="citation"/><cms:entry ref="_bib43" type="citation"/><cms:entry ref="_bib44" type="citation"/><cms:entry ref="_bib45" type="citation"/><cms:entry ref="_bib46" type="citation"/><cms:entry ref="_bib47" type="citation"/><cms:entry ref="_bib48" type="citation"/><cms:entry ref="_bib49" type="citation"/><cms:entry ref="_bib50" type="citation"/><cms:entry ref="_bib51" type="citation"/><cms:entry ref="_bib52" type="citation"/><cms:entry ref="_bib53" type="citation"/><cms:entry ref="_bib54" type="citation"/><cms:entry ref="_bib55" type="citation"/><cms:entry ref="_bib56" type="citation"/><cms:entry ref="_bib57" type="citation"/><cms:entry ref="_bib58" type="citation"/><cms:entry ref="_bib59" type="citation"/><cms:entry ref="_bib60" type="citation"/><cms:entry ref="_bib61" type="citation"/><cms:entry ref="_bib62" type="citation"/><cms:entry ref="_bib63" type="citation"/><cms:entry ref="_bib64" type="citation"/><cms:entry ref="_bib65" type="citation"/><cms:entry ref="_bib66" type="citation"/><cms:entry ref="_bib67" type="citation"/><cms:entry ref="_bib68" type="citation"/><cms:entry ref="_bib69" type="citation"/><cms:entry ref="_bib70" type="citation"/><cms:entry ref="_bib71" type="citation"/><cms:entry ref="_bib72" type="citation"/><cms:entry ref="_bib73" type="citation"/><cms:entry ref="_bib74" type="citation"/><cms:entry ref="_bib75" type="citation"/><cms:entry ref="_bib76" type="citation"/><cms:entry ref="_bib77" type="citation"/><cms:entry ref="_bib78" type="citation"/><cms:entry ref="_bib79" type="citation"/><cms:entry ref="_bib80" type="citation"/><cms:entry ref="_bib81" type="citation"/><cms:entry ref="_bib82" type="citation"/><cms:entry ref="_bib83" type="citation"/><cms:entry ref="_bib84" type="citation"/><cms:entry ref="_bib85" type="citation"/><cms:entry ref="_bib86" type="citation"/><cms:entry ref="_bib87" type="citation"/><cms:entry ref="_bib88" type="citation"/><cms:entry ref="_bib89" type="citation"/><cms:entry ref="_bib90" type="citation"/><cms:entry ref="_bib91" type="citation"/><cms:entry ref="_bib92" type="citation"/><cms:entry ref="_bib93" type="citation"/><cms:entry ref="_bib94" type="citation"/><cms:entry ref="_bib95" type="citation"/><cms:entry ref="_bib96" type="citation"/><cms:entry ref="_bib97" type="citation"/><cms:entry ref="_bib98" type="citation"/><cms:entry ref="_bib99" type="citation"/><cms:entry ref="_bib100" type="citation"/><cms:entry ref="_bib101" type="citation"/><cms:entry ref="_bib102" type="citation"/><cms:entry ref="_bib103" type="citation"/><cms:entry ref="_bib104" type="citation"/><cms:entry ref="_bib105" type="citation"/><cms:entry ref="_bib106" type="citation"/><cms:entry ref="_bib107" type="citation"/><cms:entry ref="_bib108" type="citation"/><cms:entry ref="_bib109" type="citation"/><cms:entry ref="_bib110" type="citation"/><cms:entry ref="_bib111" type="citation"/><cms:entry ref="_bib112" type="citation"/><cms:entry ref="_bib113" type="citation"/><cms:entry ref="_bib114" type="citation"/><cms:entry ref="_bib115" type="citation"/><cms:entry ref="_bib116" type="citation"/><cms:entry ref="_bib117" type="citation"/><cms:entry ref="_bib118" type="citation"/><cms:entry ref="_bib119" type="citation"/><cms:entry ref="_bib120" type="citation"/><cms:entry ref="_bib121" type="citation"/><cms:entry ref="_bib122" type="citation"/><cms:entry ref="_bib123" type="citation"/><cms:entry ref="_bib124" type="citation"/><cms:entry ref="_bib125" type="citation"/><cms:entry ref="_bib126" type="citation"/><cms:entry ref="_bib127" type="citation"/><cms:entry ref="_bib128" type="citation"/><cms:entry ref="_bib129" type="citation"/><cms:entry ref="_bib130" type="citation"/><cms:entry ref="_bib131" type="citation"/><cms:entry ref="_bib132" type="citation"/><cms:entry ref="_bib133" type="citation"/><cms:entry ref="_bib134" type="citation"/><cms:entry ref="_bib135" type="citation"/><cms:entry ref="_bib136" type="citation"/><cms:entry ref="_bib137" type="citation"/><cms:entry ref="_bib138" type="citation"/><cms:entry ref="_bib139" type="citation"/><cms:entry ref="_bib140" 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				Anhang</cms:entry><cms:entry id="N12221" part="N1221F" ref="N12221" type="head"/><cms:entry id="N12223" part="N1221F" ref="N12223" type="pagenumber">96</cms:entry><cms:entry id="N12228" part="N1221F" ref="N12228" type="p"/><cms:entry id="N1222B" part="N1221F" ref="N1222B" type="p"/><cms:entry id="N1222E" part="N1221F" ref="N1222E" type="p"/><cms:entry id="_1146392224" part="N1221F" ref="_1146392224" type="link"/><cms:entry id="_1149667707" part="N1221F" ref="_1149667707" type="link"/><cms:entry id="N12236" part="N1221F" ref="N12236" type="mm">269#289</cms:entry><cms:entry id="N1223B" part="N1221F" ref="N1223B" type="p"/><cms:entry id="N1223D" part="N1221F" ref="N1223D" type="pagenumber">97</cms:entry><cms:entry id="N12243" part="N12243" ref="N12243" type="acknowledgement">Danksagung</cms:entry><cms:entry id="N1225C" part="N12243" ref="N1225C" type="pagenumber">98</cms:entry><cms:entry id="N12262" part="N12262" ref="N12262" type="vita">Lebenslauf</cms:entry><cms:entry id="N12269" part="N12262" ref="N12269" type="table"/><cms:entry id="N123D0" part="N12262" ref="N123D0" type="pagenumber">99</cms:entry><cms:entry id="N123D6" part="N123D6" ref="N123D6" type="declaration">Eidestattliche Erklärung</cms:entry><cms:entry part="N10AE6" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N10AE6">
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				<pagenumber id="N10AED" label="65" numbering="arabic" start="65"/>Literaturverzeichnis</head>
				
<p>[1]
<citation id="_bib1" published="yes" workType="Journal"><workauthor>Pienta, K. J. und Esper, P. S.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Risk factors for prostate cancer</articletitle>, <worktitle>Ann.Intern.Med.</worktitle> <volume>118</volume> [<number>10</number>], Seite <pages>793</pages>-<pages>803</pages>. </citation>[2]
<citation id="_bib2" published="yes" workType="Misc"><workauthor>Robert - Koch - Institut</workauthor>:<worktitle>Tumorregister</worktitle>.URL: <url href="www.rki.de/GBE/KREBS/KREBS.HTM?/GBE/KREBS/SCHAETZUNG/KREBSNEUERKRANKUNGEN1998.HTM&amp;1" type="URL">www.rki.de/GBE/KREBS/KREBS.HTM?/GBE/KREBS/SCHAETZUNG/KREBSNEUERKRANKUNGEN1998.HTM&amp;1</url> </citation>
[3] <citation id="_bib3" published="yes" workType="Journal"><workauthor>Jemal, A.; Tiwari, R. C.; Murray, T.; Ghafoor, A.; Samuels, A.; Ward, E.; Feuer, E. J. und Thun, M. J.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Cancer statistics, 2004</articletitle>, <worktitle>CA Cancer J Clin.</worktitle> <volume>54</volume> [<number>1</number>], Seite <pages>8</pages>-<pages>29</pages>. </citation>
[4] <citation id="_bib4" published="yes" workType="Journal"><workauthor>Hankey, B. F.; Feuer, E. J.; Clegg, L. X.; Hayes, R. B.; Legler, J. M.; Prorok, P. C.; Ries, L. A.; Merrill, R. M. und Kaplan, R. S.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Cancer surveillance series: interpreting trends in prostate cancer--part I: Evidence of the effects of screening in recent prostate cancer incidence, mortality, and survival rates</articletitle>, <worktitle>J Natl.Cancer Inst.</worktitle> <volume>91</volume> [<number>12</number>], Seite <pages>1017</pages>-<pages>1024</pages>. </citation>
[5] <citation id="_bib5" published="yes" workType="Journal"><workauthor>Chybowski, F. M.; Keller, J. J.; Bergstralh, E. J. und Oesterling, J. E.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Predicting radionuclide bone scan findings in patients with newly diagnosed, untreated prostate cancer: prostate specific antigen is superior to all other clinical parameters</articletitle>, <worktitle>J Urol.</worktitle> <volume>145</volume> [<number>2</number>], Seite <pages>313</pages>-<pages>318</pages>. </citation>
[6] <citation id="_bib6" published="yes" workType="Journal"><workauthor>Smith, D. S. und Catalona, W. J.</workauthor> (<pubdate>1994</pubdate>): <articletitle>The nature of prostate cancer detected through prostate specific antigen based screening</articletitle>, <worktitle>J Urol.</worktitle> <volume>152</volume> [<number>5 Pt 2</number>], Seite <pages>1732</pages>-<pages>1736</pages>. </citation>
[7] <citation id="_bib7" published="yes" workType="Journal"><workauthor>Harlan, L.; Brawley, O.; Pommerenke, F.; Wali, P. und Kramer, B.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Geographic, age, and racial variation in the treatment of local/regional carcinoma of the prostate</articletitle>, <worktitle>J Clin.Oncol.</worktitle> <volume>13</volume> [<number>1</number>], Seite <pages>93</pages>-<pages>100</pages>. </citation>
[8] <citation id="_bib8" published="yes" workType="Journal"><workauthor>Johansson, J. E.; Adami, H. O.; Andersson, S. O.; Bergstrom, R.; Krusemo, U. B. und Kraaz, W.</workauthor> (<pubdate>1989</pubdate>): <articletitle>Natural history of localised prostatic cancer. A population-based study in 223 untreated patients</articletitle>, <worktitle>Lancet</worktitle> <volume>1</volume> [<number>8642</number>], Seite <pages>799</pages>-<pages>803</pages>. </citation>
[9] <citation id="_bib9" published="yes" workType="Journal"><workauthor>Walsh, P. C.; Partin, A. W. und Epstein, J. I.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Cancer control and quality of life following anatomical radical retropubic prostatectomy: results at 10 years</articletitle>, <worktitle>J Urol.</worktitle> <volume>152</volume> [<number>5 Pt 2</number>], Seite <pages>1831</pages>-<pages>1836</pages>. </citation>
[10] <citation id="_bib10" published="yes" workType="Journal"><workauthor>Deger, S.; Boehmer, D.; Turk, I.; Roigas, J.; Wernecke, K. D.; Wiegel, T.; Hinkelbein, W.; Dinges, S.; Budach, V. und Loening, S. A.</workauthor> (<pubdate>2002</pubdate>): <articletitle>High dose rate brachytherapy of localized prostate cancer</articletitle>, <worktitle>Eur.Urol.</worktitle> <volume>41</volume> [<number>4</number>], Seite <pages>420</pages>-<pages>426</pages>. </citation>
[11] <citation id="_bib11" published="yes" workType="Journal"><workauthor>Zincke, H.; Oesterling, J. E.; Blute, M. L.; Bergstralh, E. J.; Myers, R. P. und Barrett, D. M.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer</articletitle>, <worktitle>J Urol.</worktitle> <volume>152</volume> [<number>5 Pt 2</number>], Seite <pages>1850</pages>-<pages>1857</pages>. </citation>
[12] <citation id="_bib12" published="yes" workType="Journal"><workauthor>Carlin, B. I. und Andriole, G. L.</workauthor> (<pubdate>2000</pubdate>): <articletitle>The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma</articletitle>, <worktitle>Cancer</worktitle> <volume>88</volume> [<number>12 Suppl</number>], Seite <pages>2989</pages>-<pages>2994</pages>. </citation>
[13] <citation id="_bib13" published="yes" workType="Journal"><workauthor>Whitmore, W. F., Jr.</workauthor> (<pubdate>1984</pubdate>): <articletitle>Natural history and staging of prostate cancer</articletitle>, <worktitle>Urol.Clin.North Am.</worktitle> <volume>11</volume> [<number>2</number>], Seite <pages>205</pages>-<pages>220</pages>. </citation>
[14] <citation id="_bib14" published="yes" workType="Journal"><workauthor>Nagase, H. und Woessner, J. F., Jr.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Matrix metalloproteinases</articletitle>, <worktitle>J Biol.Chem.</worktitle> <volume>274</volume> [<number>31</number>], Seite <pages>21491</pages>-<pages>21494</pages>. </citation>
[15] <citation id="_bib15" published="yes" workType="Journal"><workauthor>Vihinen, P. und Kahari, V. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>99</volume> [<number>2</number>], Seite <pages>157</pages>-<pages>166</pages>. </citation>
[16] <citation id="_bib16" published="yes" workType="Book"><workauthor>Barrett, A. J.; Rawlings, N. D. und Woessner, J. F., Jr.</workauthor> (<pubdate>1998</pubdate>): <worktitle>Handbook of Proteolytic Enzymes</worktitle>, <address>San Diego</address>, <url href="0-12-079370-9" type="ISBN">0-12-079370-9</url>. </citation>
[17] <citation id="_bib17" published="yes" workType="Book"><workauthor>Sterchi, E. E. und Stöcker, W.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Proteolytic Enzymes - Tools and Targets</articletitle>, Seite <pages>1</pages>-<pages>11</pages>, <publisher>Springer- Verlag</publisher>, <url href="3-540-61233-5" type="ISBN">3-540-61233-5</url>. </citation>
[18] <citation id="_bib18" published="yes" workType="Journal"><workauthor>Hulboy, D. L.; Rudolph, L. A. und Matrisian, L. M.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Matrix metalloproteinases as mediators of reproductive function</articletitle>, <worktitle>Mol.Hum.Reprod.</worktitle> <volume>3</volume> [<number>1</number>], Seite <pages>27</pages>-<pages>45</pages>. </citation>
[19] <citation id="_bib19" published="yes" workType="Journal"><workauthor>Bullard, K. M.; Lund, L.; Mudgett, J. S.; Mellin, T. N.; Hunt, T. K.; Murphy, B.; Ronan, J.; Werb, Z. und Banda, M. J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Impaired wound contraction in stromelysin-1-deficient mice</articletitle>, <worktitle>Ann.Surg.</worktitle> <volume>230</volume> [<number>2</number>], Seite <pages>260</pages>-<pages>265</pages>. </citation>
[20] <citation id="_bib20" published="yes" workType="Journal"><workauthor>Alexander, C. M.; Hansell, E. J.; Behrendtsen, O.; Flannery, M. L.; Kishnani, N. S.; Hawkes, S. P. und Werb, Z.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation</articletitle>, <worktitle>Development</worktitle> <volume>122</volume> [<number>6</number>], Seite <pages>1723</pages>-<pages>1736</pages>. </citation>
[21] <citation id="_bib21" published="yes" workType="Journal"><workauthor>Gearing, A. J.; Beckett, P.; Christodoulou, M.; Churchill, M.; Clements, J.; Davidson, A. H.; Drummond, A. H.; Galloway, W. A.; Gilbert, R. und Gordon, J. L.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Processing of tumour necrosis factor-alpha precursor by metalloproteinases</articletitle>, <worktitle>Nature</worktitle> <volume>370</volume> [<number>6490</number>], Seite <pages>555</pages>-<pages>557</pages>. </citation>
[22] <citation id="_bib22" published="yes" workType="Journal"><workauthor>Dubois, B.; Starckx, S.; Pagenstecher, A.; Oord, J.; Arnold, B. und Opdenakker, G.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Gelatinase B deficiency protects against endotoxin shock</articletitle>, <worktitle>Eur.J Immunol</worktitle> <volume>32</volume> [<number>8</number>], Seite <pages>2163</pages>-<pages>2171</pages>. </citation>
[23] <citation id="_bib23" published="yes" workType="Journal"><workauthor>Kim, J.; Yu, W.; Kovalski, K. und Ossowski, L.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay</articletitle>, <worktitle>Cell</worktitle> <volume>94</volume> [<number>3</number>], Seite <pages>353</pages>-<pages>362</pages>. </citation>
[24] <citation id="_bib24" published="yes" workType="Journal"><workauthor>Lochter, A.; Galosy, S.; Muschler, J.; Freedman, N.; Werb, Z. und Bissell, M. J.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells</articletitle>, <worktitle>J Cell Biol.</worktitle> <volume>139</volume> [<number>7</number>], Seite <pages>1861</pages>-<pages>1872</pages>. </citation>
[25] <citation id="_bib25" published="yes" workType="Journal"><workauthor>Ala-Aho, R.; Johansson, N.; Baker, A. H. und Kahari, V. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>97</volume> [<number>3</number>], Seite <pages>283</pages>-<pages>289</pages>. </citation>
[26] <citation id="_bib26" published="yes" workType="Journal"><workauthor>Bernhard, E. J.; Gruber, S. B. und Muschel, R. J.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>91</volume> [<number>10</number>], Seite <pages>4293</pages>-<pages>4297</pages>. </citation>
[27] <citation id="_bib27" published="yes" workType="Journal"><workauthor>Werb, Z.</workauthor> (<pubdate>1997</pubdate>): <articletitle>ECM and cell surface proteolysis: regulating cellular ecology</articletitle>, <worktitle>Cell</worktitle> <volume>91</volume> [<number>4</number>], Seite <pages>439</pages>-<pages>442</pages>. </citation>
[28] <citation id="_bib28" published="yes" workType="Journal"><workauthor>Johnson, L. L.; Pavlovsky, A. G.; Johnson, A. R.; Janowicz, J. A.; Man, C. F.; Ortwine, D. F.; Purchase, C. F.; White, A. D. und Hupe, D. J.</workauthor> (<pubdate>2000</pubdate>): <articletitle>A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition</articletitle>, <worktitle>J Biol.Chem.</worktitle> <volume>275</volume> [<number>15</number>], Seite <pages>11026</pages>-<pages>11033</pages>. </citation>
[29] <citation id="_bib29" published="yes" workType="Journal"><workauthor>Borkakoti, N.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Matrix metalloproteases: variations on a theme</articletitle>, <worktitle>Prog.Biophys.Mol.Biol.</worktitle> <volume>70</volume> [<number>1</number>], Seite <pages>7</pages>-<pages>94</pages>. </citation>
[30] <citation id="_bib30" published="yes" workType="Journal"><workauthor>Van Wart, H. E. und Birkedal-Hansen, H.</workauthor> (<pubdate>1990</pubdate>): <articletitle>The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>87</volume> [<number>14</number>], Seite <pages>5578</pages>-<pages>5582</pages>. </citation>
[31] <citation id="_bib31" published="yes" workType="Journal"><workauthor>Sato, H.; Takino, T.; Okada, Y.; Cao, J.; Shinagawa, A.; Yamamoto, E. und Seiki, M.</workauthor> (<pubdate>1994</pubdate>): <articletitle>A matrix metalloproteinase expressed on the surface of invasive tumour cells</articletitle>, <worktitle>Nature</worktitle> <volume>370</volume> [<number>6484</number>], Seite <pages>61</pages>-<pages>65</pages>. </citation>
[32] <citation id="_bib32" published="yes" workType="Journal"><workauthor>Cox, G.; Steward, W. P. und O'Byrne, K. J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer</articletitle>, <worktitle>Thorax</worktitle> <volume>54</volume> [<number>2</number>], Seite <pages>169</pages>-<pages>179</pages>. </citation>
[33] <citation id="_bib33" published="yes" workType="Journal"><workauthor>Woolley, D. E.; Roberts, D. R. und Evanson, J. M.</workauthor> (<pubdate>1976</pubdate>): <articletitle>Small molecular weight beta 1 serum protein which specifically inhibits human collagenases</articletitle>, <worktitle>Nature</worktitle> <volume>261</volume> [<number>5558</number>], Seite <pages>325</pages>-<pages>327</pages>. </citation>
[34] <citation id="_bib34" published="yes" workType="Journal"><workauthor>Jiang, Y.; Goldberg, I. D. und Shi, Y. E.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Complex roles of tissue inhibitors of metalloproteinases in cancer</articletitle>, <worktitle>Oncogene</worktitle> <volume>21</volume> [<number>14</number>], Seite <pages>2245</pages>-<pages>2252</pages>. </citation>
[35] <citation id="_bib35" published="yes" workType="Journal"><workauthor>Pavlaki, M. und Zucker, S.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Matrix metalloproteinase inhibitors (MMPIs): the beginning of phase I or the termination of phase III clinical trials</articletitle>, <worktitle>Cancer Metastasis Rev.</worktitle> <volume>22</volume> [<number>2-3</number>], Seite <pages>177</pages>-<pages>203</pages>. </citation>
[36] <citation id="_bib36" published="yes" workType="Journal"><workauthor>Nuovo, G. J.; MacConnell, P. B.; Simsir, A.; Valea, F. und French, D. L.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Correlation of the in situ detection of polymerase chain reaction- amplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>55</volume> [<number>2</number>], Seite <pages>267</pages>-<pages>275</pages>. </citation>
[37] <citation id="_bib37" published="yes" workType="Journal"><workauthor>Coussens, L. M. und Werb, Z.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Matrix metalloproteinases and the development of cancer</articletitle>, <worktitle>Chem.Biol.</worktitle> <volume>3</volume> [<number>11</number>], Seite <pages>895</pages>-<pages>904</pages>. </citation>
[38] <citation id="_bib38" published="yes" workType="Journal"><workauthor>Goss, K. J.; Brown, P. D. und Matrisian, L. M.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis</articletitle>, <worktitle>Int.J.Cancer</worktitle> <volume>78</volume> [<number>5</number>], Seite <pages>629</pages>-<pages>635</pages>. </citation>
[39] <citation id="_bib39" published="yes" workType="Journal"><workauthor>Gasson, J. C.; Golde, D. W.; Kaufman, S. E.; Westbrook, C. A.; Hewick, R. M.; Kaufman, R. J.; Wong, G. G.; Temple, P. A.; Leary, A. C.; Brown, E. L. und .</workauthor> (<pubdate>1985</pubdate>): <articletitle>Molecular characterization and expression of the gene encoding human erythroid-potentiating activity</articletitle>, <worktitle>Nature</worktitle> <volume>315</volume> [<number>6022</number>], Seite <pages>768</pages>-<pages>771</pages>. </citation>
[40] <citation id="_bib40" published="yes" workType="Journal"><workauthor>DeClerck, Y. A. und Imren, S.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Protease inhibitors: role and potential therapeutic use in human cancer</articletitle>, <worktitle>Eur.J Cancer</worktitle> <volume>30A</volume> [<number>14</number>], Seite <pages>2170</pages>-<pages>2180</pages>. </citation>
[41] <citation id="_bib41" published="yes" workType="Journal"><workauthor>Wilson, C. L.; Heppner, K. J.; Labosky, P. A.; Hogan, B. L. und Matrisian, L. M.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>94</volume> [<number>4</number>], Seite <pages>1402</pages>-<pages>1407</pages>. </citation>
[42] <citation id="_bib42" published="yes" workType="Journal"><workauthor>Khokha, R. und Denhardt, D. T.</workauthor> (<pubdate>1989</pubdate>): <articletitle>Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion</articletitle>, <worktitle>Invasion Metastasis</worktitle> <volume>9</volume> [<number>6</number>], Seite <pages>391</pages>-<pages>405</pages>. </citation>
[43] <citation id="_bib43" published="yes" workType="Journal"><workauthor>Hashimoto, K.; Kihira, Y.; Matuo, Y. und Usui, T.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Expression of matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-1 in human prostate</articletitle>, <worktitle>J Urol.</worktitle> <volume>160</volume> [<number>5</number>], Seite <pages>1872</pages>-<pages>1876</pages>. </citation>
[44] <citation id="_bib44" published="yes" workType="Journal"><workauthor>Koop, S.; Khokha, R.; Schmidt, E. E.; MacDonald, I. C.; Morris, V. L.; Chambers, A. F. und Groom, A. C.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>54</volume> [<number>17</number>], Seite <pages>4791</pages>-<pages>4797</pages>. </citation>
[45] <citation id="_bib45" published="yes" workType="Journal"><workauthor>Wojtowicz-Praga, S. M.; Dickson, R. B. und Hawkins, M. J.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Matrix metalloproteinase inhibitors</articletitle>, <worktitle>Invest New Drugs</worktitle> <volume>15</volume> [<number>1</number>], Seite <pages>61</pages>-<pages>75</pages>. </citation>
[46] <citation id="_bib46" published="yes" workType="Journal"><workauthor>Grant, G. M.; Giambernardi, T. A.; Grant, A. M. und Klebe, R. J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Overview of expression of matrix metalloproteinases (MMP-17, MMP-18, and MMP-20) in cultured human cells</articletitle>, <worktitle>Matrix Biol.</worktitle> <volume>18</volume> [<number>2</number>], Seite <pages>145</pages>-<pages>148</pages>. </citation>
[47] <citation id="_bib47" published="yes" workType="Journal"><workauthor>Greene, G. F.; Kitadai, Y.; Pettaway, C. A.; von Eschenbach, A. C.; Bucana, C. D. und Fidler, I. J.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique</articletitle>, <worktitle>Am.J Pathol.</worktitle> <volume>150</volume> [<number>5</number>], Seite <pages>1571</pages>-<pages>1582</pages>. </citation>
[48] <citation id="_bib48" published="yes" workType="Journal"><workauthor>Wilson, M. J.; Sellers, R. G.; Wiehr, C.; Melamud, O.; Pei, D. und Peehl, D. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells</articletitle>, <worktitle>J Cell Physiol</worktitle> <volume>191</volume> [<number>2</number>], Seite <pages>208</pages>-<pages>216</pages>. </citation>
[49] <citation id="_bib49" published="yes" workType="Journal"><workauthor>Zhang, J.; Jung, K.; Lein, M.; Kristiansen, G.; Rudolph, B.; Hauptmann, S.; Schnorr, D.; Loening, S. A. und Lichtinghagen, R.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines</articletitle>, <worktitle>Prostate</worktitle> <volume>50</volume> [<number>1</number>], Seite <pages>38</pages>-<pages>45</pages>. </citation>
[50] <citation id="_bib50" published="yes" workType="Journal"><workauthor>Li, H.; Fang, W. und Zheng, J.</workauthor> (<pubdate>1998</pubdate>): <articletitle>[Zymographic analysis of MMPs in human carcinoma cell lines with different metastasis potential]</articletitle>, <worktitle>Zhonghua Bing.Li Xue.Za Zhi.</worktitle> <volume>27</volume> [<number>5</number>], Seite <pages>341</pages>-<pages>343</pages>. </citation>
[51] <citation id="_bib51" published="yes" workType="Journal"><workauthor>Powell, W. C.; Fingleton, B.; Wilson, C. L.; Boothby, M. und Matrisian, L. M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis</articletitle>, <worktitle>Curr.Biol.</worktitle> <volume>9</volume> [<number>24</number>], Seite <pages>1441</pages>-<pages>1447</pages>. </citation>
[52] <citation id="_bib52" published="yes" workType="Journal"><workauthor>Sanchez-Sweatman, O. H.; Orr, F. W. und Singh, G.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Human metastatic prostate PC3 cell lines degrade bone using matrix metalloproteinases [In Process Citation]</articletitle>, <worktitle>Invasion Metastasis</worktitle> <volume>18</volume> [<number>5-6</number>], Seite <pages>297</pages>-<pages>305</pages>. </citation>
[53] <citation id="_bib53" published="yes" workType="Journal"><workauthor>Sternlicht, M. D.; Lochter, A.; Sympson, C. J.; Huey, B.; Rougier, J. P.; Gray, J. W.; Pinkel, D.; Bissell, M. J. und Werb, Z.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis</articletitle>, <worktitle>Cell</worktitle> <volume>98</volume> [<number>2</number>], Seite <pages>137</pages>-<pages>146</pages>. </citation>
[54] <citation id="_bib54" published="yes" workType="Journal"><workauthor>Kolkhorst, V.; Sturzebecher, J. und Wiederanders, B.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profile</articletitle>, <worktitle>J.Cancer Res.Clin.Oncol.</worktitle> <volume>124</volume> [<number>11</number>], Seite <pages>598</pages>-<pages>606</pages>. </citation>
[55] <citation id="_bib55" published="yes" workType="Journal"><workauthor>Codony-Servat, J.; Albanell, J.; Lopez-Talavera, J. C.; Arribas, J. und Baselga, J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>59</volume> [<number>6</number>], Seite <pages>1196</pages>-<pages>1201</pages>. </citation>
[56] <citation id="_bib56" published="yes" workType="Journal"><workauthor>Dong, J.; Opresko, L. K.; Dempsey, P. J.; Lauffenburger, D. A.; Coffey, R. J. und Wiley, H. S.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor</articletitle>, <worktitle>Proc.Natl.Acad.Sci U.S.A</worktitle> <volume>96</volume> [<number>11</number>], Seite <pages>6235</pages>-<pages>6240</pages>. </citation>
[57] <citation id="_bib57" published="yes" workType="Journal"><workauthor>Festuccia, C.; Bologna, M.; Vicentini, C.; Tacconelli, A.; Miano, R.; Violini, S. und Mackay, A. R.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Increased matrix metalloproteinase-9 secretion in short-term tissue cultures of prostatic tumor cells</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>69</volume> [<number>5</number>], Seite <pages>386</pages>-<pages>393</pages>. </citation>
[58] <citation id="_bib58" published="yes" workType="Journal"><workauthor>Hamdy, F. C.; Fadlon, E. J.; Cottam, D.; Lawry, J.; Thurrell, W.; Silcocks, P. B.; Anderson, J. B.; Williams, J. L. und Rees, R. C.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia</articletitle>, <worktitle>Br J Cancer</worktitle> <volume>69</volume> [<number>1</number>], Seite <pages>177</pages>-<pages>182</pages>. </citation>
[59] <citation id="_bib59" published="yes" workType="Journal"><workauthor>Knox, J. D.; Wolf, C.; McDaniel, K.; Clark, V.; Loriot, M.; Bowden, G. T. und Nagle, R. B.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Matrilysin expression in human prostate carcinoma</articletitle>, <worktitle>Mol.Carcinog.</worktitle> <volume>15</volume> [<number>1</number>], Seite <pages>57</pages>-<pages>63</pages>. </citation>
[60] <citation id="_bib60" published="yes" workType="Journal"><workauthor>Stearns, M. und Stearns, M. E.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression</articletitle>, <worktitle>Oncol.Res.</worktitle> <volume>8</volume> [<number>2</number>], Seite <pages>69</pages>-<pages>75</pages>. </citation>
[61] <citation id="_bib61" published="yes" workType="Journal"><workauthor>Stearns, M. E. und Stearns, M.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Immunohistochemical studies of activated matrix metalloproteinase-2 (MMP-2a)expression in human prostate cancer</articletitle>, <worktitle>Oncol.Res.</worktitle> <volume>8</volume> [<number>2</number>], Seite <pages>63</pages>-<pages>67</pages>. </citation>
[62] <citation id="_bib62" published="yes" workType="Journal"><workauthor>Still, K.; Robson, C. N.; Autzen, P.; Robinson, M. C. und Hamdy, F. C.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Localization and quantification of mRNA for matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in human benign and malignant prostatic tissue</articletitle>, <worktitle>Prostate</worktitle> <volume>42</volume> [<number>1</number>], Seite <pages>18</pages>-<pages>25</pages>. </citation>
[63] <citation id="_bib63" published="yes" workType="Journal"><workauthor>Wood, M.; Fudge, K.; Mohler, J. L.; Frost, A. R.; Garcia, F.; Wang, M. und Stearns, M. E.</workauthor> (<pubdate>1997</pubdate>): <articletitle>In situ hybridization studies of metalloproteinases 2 and 9 and TIMP-1 and TIMP-2 expression in human prostate cancer</articletitle>, <worktitle>Clin.Exp.Metastasis</worktitle> <volume>15</volume> [<number>3</number>], Seite <pages>246</pages>-<pages>258</pages>. </citation>
[64] <citation id="_bib64" published="yes" workType="Journal"><workauthor>Festuccia, C.; Giunciuglio, D.; Guerra, F.; Villanova, I.; Angelucci, A.; Manduca, P.; Teti, A.; Albini, A. und Bologna, M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Osteoblasts modulate secretion of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) in human prostate cancer cells promoting migration and matrigel invasion</articletitle>, <worktitle>Oncol.Res.</worktitle> <volume>11</volume> [<number>1</number>], Seite <pages>17</pages>-<pages>31</pages>. </citation>
[65] <citation id="_bib65" published="yes" workType="Journal"><workauthor>Hiraoka, N.; Allen, E.; Apel, I. J.; Gyetko, M. R. und Weiss, S. J.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins</articletitle>, <worktitle>Cell</worktitle> <volume>95</volume> [<number>3</number>], Seite <pages>365</pages>-<pages>377</pages>. </citation>
[66] <citation id="_bib66" published="yes" workType="Journal"><workauthor>Masson, R.; Lefebvre, O.; Noel, A.; Fahime, M. E.; Chenard, M. P.; Wendling, C.; Kebers, F.; LeMeur, M.; Dierich, A.; Foidart, J. M.; Basset, P. und Rio, M. C.</workauthor> (<pubdate>1998</pubdate>): <articletitle>In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy</articletitle>, <worktitle>J.Cell Biol.</worktitle> <volume>140</volume> [<number>6</number>], Seite <pages>1535</pages>-<pages>1541</pages>. </citation>
[67] <citation id="_bib67" published="yes" workType="Journal"><workauthor>McKerrow, J. H.; Bhargava, V.; Hansell, E.; Huling, S.; Kuwahara, T.; Matley, M.; Coussens, L. und Warren, R.</workauthor> (<pubdate>2000</pubdate>): <articletitle>A functional proteomics screen of proteases in colorectal carcinoma</articletitle>, <worktitle>Mol.Med.</worktitle> <volume>6</volume> [<number>5</number>], Seite <pages>450</pages>-<pages>460</pages>. </citation>
[68] <citation id="_bib68" published="yes" workType="Journal"><workauthor>Knox, J. D.; Bretton, L.; Lynch, T.; Bowden, G. T. und Nagle, R. B.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model</articletitle>, <worktitle>Prostate</worktitle> <volume>35</volume> [<number>4</number>], Seite <pages>248</pages>-<pages>254</pages>. </citation>
[69] <citation id="_bib69" published="yes" workType="Journal"><workauthor>Hofmann, U. B.; Westphal, J. R.; Zendman, A. J.; Becker, J. C.; Ruiter, D. J. und van Muijen, G. N.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression</articletitle>, <worktitle>J Pathol.</worktitle> <volume>191</volume> [<number>3</number>], Seite <pages>245</pages>-<pages>256</pages>. </citation>
[70] <citation id="_bib70" published="yes" workType="Journal"><workauthor>Zervos, E. E.; Shafii, A. E. und Rosemurgy, A. S.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Matrix metalloproteinase (MMP) inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer</articletitle>, <worktitle>J.Surg.Res.</worktitle> <volume>81</volume> [<number>1</number>], Seite <pages>65</pages>-<pages>68</pages>. </citation>
[71] <citation id="_bib71" published="yes" workType="Journal"><workauthor>Lokeshwar, B. L.</workauthor> (<pubdate>1999</pubdate>): <articletitle>MMP inhibition in prostate cancer</articletitle>, <worktitle>Ann.N.Y.Acad.Sci.</worktitle> <volume>878</volume>, Seite <pages>271</pages>-<pages>289</pages>. </citation>
[72] <citation id="_bib72" published="yes" workType="Journal"><workauthor>Nemeth, J. A.; Yousif, R.; Herzog, M.; Che, M.; Upadhyay, J.; Shekarriz, B.; Bhagat, S.; Mullins, C.; Fridman, R. und Cher, M. L.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis</articletitle>, <worktitle>J Natl.Cancer Inst.</worktitle> <volume>94</volume> [<number>1</number>], Seite <pages>17</pages>-<pages>25</pages>. </citation>
[73] <citation id="_bib73" published="yes" workType="Journal"><workauthor>Sternlicht, M. D.; Bissell, M. J. und Werb, Z.</workauthor> (<pubdate>2000</pubdate>): <articletitle>The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter</articletitle>, <worktitle>Oncogene</worktitle> <volume>19</volume> [<number>8</number>], Seite <pages>1102</pages>-<pages>1113</pages>. </citation>
[74] <citation id="_bib74" published="yes" workType="Journal"><workauthor>Fingleton, B. M.; Heppner Goss, K. J.; Crawford, H. C. und Matrisian, L. M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Matrilysin in early stage intestinal tumorigenesis</articletitle>, <worktitle>APMIS</worktitle> <volume>107</volume> [<number>1</number>], Seite <pages>102</pages>-<pages>110</pages>. </citation>
[75] <citation id="_bib75" published="yes" workType="Journal"><workauthor>Cockett, M. I.; Murphy, G.; Birch, M. L.; O'Connell, J. P.; Crabbe, T.; Millican, A. T.; Hart, I. R. und Docherty, A. J.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Matrix metalloproteinases and metastatic cancer</articletitle>, <worktitle>Biochem.Soc.Symp.</worktitle> <volume>63</volume>, Seite <pages>295</pages>-<pages>313</pages>. </citation>
[76] <citation id="_bib76" published="yes" workType="Journal"><workauthor>Parsons, S. L.; Watson, S. A.; Collins, H. M.; Griffin, N. R.; Clarke, P. A. und Steele, R. J.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy</articletitle>, <worktitle>Br.J.Cancer</worktitle> <volume>78</volume> [<number>11</number>], Seite <pages>1495</pages>-<pages>1502</pages>. </citation>
[77] <citation id="_bib77" published="yes" workType="Journal"><workauthor>Lein, M.; Nowak, L.; Jung, K.; Koenig, F.; Schnorr, D. und Loening, S. A.</workauthor> (<pubdate>1998</pubdate>): <articletitle>[Metalloproteinases (MMP-1, MMP-3) and their inhibitors (TIMP) in blood plasma of patients with prostate carcinoma]</articletitle>, <worktitle>Urologe A</worktitle> <volume>37</volume> [<number>4</number>], Seite <pages>377</pages>-<pages>381</pages>. </citation>
[78] <citation id="_bib78" published="yes" workType="Journal"><workauthor>Ahmad, A.; Hanby, A.; Dublin, E.; Poulsom, R.; Smith, P.; Barnes, D.; Rubens, R.; Anglard, P. und Hart, I.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression</articletitle>, <worktitle>Am.J Pathol.</worktitle> <volume>152</volume> [<number>3</number>], Seite <pages>721</pages>-<pages>728</pages>. </citation>
[79] <citation id="_bib79" published="yes" workType="Journal"><workauthor>Reich, R.; Thompson, E. W.; Iwamoto, Y.; Martin, G. R.; Deason, J. R.; Fuller, G. C. und Miskin, R.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>48</volume> [<number>12</number>], Seite <pages>3307</pages>-<pages>3312</pages>. </citation>
[80] <citation id="_bib80" published="yes" workType="Journal"><workauthor>Davies, B.; Brown, P. D.; East, N.; Crimmin, M. J. und Balkwill, F. R.</workauthor> (<pubdate>1993</pubdate>): <articletitle>A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts [published erratum appears in Cancer Res 1993 Aug 1;53(15):3652]</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>53</volume> [<number>9</number>], Seite <pages>2087</pages>-<pages>2091</pages>. </citation>
[81] <citation id="_bib81" published="yes" workType="Journal"><workauthor>Santos, O.; McDermott, C. D.; Daniels, R. G. und Appelt, K.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases</articletitle>, <worktitle>Clin.Exp.Metastasis</worktitle> <volume>15</volume> [<number>5</number>], Seite <pages>499</pages>-<pages>508</pages>. </citation>
[82] <citation id="_bib82" published="yes" workType="Journal"><workauthor>Shalinsky, D. R.; Brekken, J.; Zou, H.; Bloom, L. A.; McDermott, C. D.; Zook, S.; Varki, N. M. und Appelt, K.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>5</volume> [<number>7</number>], Seite <pages>1905</pages>-<pages>1917</pages>. </citation>
[83] <citation id="_bib83" published="yes" workType="Journal"><workauthor>Bu, W.; Tang, Z. Y.; Sun, F. X.; Ye, S. L.; Liu, K. D.; Xue, Q.; Chen, J. und Gao, D. M.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20</articletitle>, <worktitle>Hepatogastroenterology.</worktitle> <volume>45</volume> [<number>22</number>], Seite <pages>1056</pages>-<pages>1061</pages>. </citation>
[84] <citation id="_bib84" published="yes" workType="Journal"><workauthor>Giavazzi, R.; Garofalo, A.; Ferri, C.; Lucchini, V.; Bone, E. A.; Chiari, S.; Brown, P. D.; Nicoletti, M. I. und Taraboletti, G.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts</articletitle>, <worktitle>CLIN.CANC.RES.</worktitle> <volume>4/4</volume> [<number>985-992</number>]-<pages>992</pages>. </citation>
[85] <citation id="_bib85" published="yes" workType="Journal"><workauthor>Zervos, E. E.; Norman, J. G.; Gower, W. R.; Franz, M. G. und Rosemurgy, A. S.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo</articletitle>, <worktitle>J.Surg.Res.</worktitle> <volume>69</volume> [<number>2</number>], Seite <pages>367</pages>-<pages>371</pages>. </citation>
[86] <citation id="_bib86" published="yes" workType="Journal"><workauthor>Sledge-GW, Jr; Qulali, M.; Goulet, R.; Bone, E. A. und Fife, R.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice</articletitle>, <worktitle>J.Natl.Cancer Inst.</worktitle> <volume>87</volume> [<number>20</number>], Seite <pages>1546</pages>-<pages>1550</pages>. </citation>
[87] <citation id="_bib87" published="yes" workType="Journal"><workauthor>Wang, X.; Fu, X.; Brown, P. D.; Crimmin, M. J. und Hoffman, R. M.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>54</volume> [<number>17</number>], Seite <pages>4726</pages>-<pages>4728</pages>. </citation>
[88] <citation id="_bib88" published="yes" workType="Journal"><workauthor>Anderson, I. C.; Shipp, M. A.; Docherty, A. J. und Teicher, B. A.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>56</volume> [<number>4</number>], Seite <pages>715</pages>-<pages>718</pages>. </citation>
[89] <citation id="_bib89" published="yes" workType="Journal"><workauthor>Macaulay, V. M.; O'Byrne, K. J.; Saunders, M. P.; Braybrooke, J. P.; Long, L.; Gleeson, F.; Mason, C. S.; Harris, A. L.; Brown, P. und Talbot, D. C.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Phase I study of matrix metalloproteinase (MMP) inhibitor batimastat (BB-94) in patients with malignant pleural effusions.</articletitle>, <worktitle>Br J Cancer</worktitle> <volume>71(Suppl XXIV)</volume> [<number>11(Abstr)</number>]. </citation>
[90] <citation id="_bib90" published="yes" workType="Misc"><workauthor>Beattie, G. J., Young, H. A., and Smyth, J. F.</workauthor>:<worktitle>Phase I study of intraperitoneal metalloproteinase inhibitor BB-94 in patients with malignant ascites.</worktitle>, <publisher>8th NCI-EORTC Symposium on New Drug Development, Amsterdam, March 1994</publisher>. </citation>
[91] <citation id="_bib91" published="yes" workType="Journal"><workauthor>Hidalgo, M. und Eckhardt, S. G.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Development of matrix metalloproteinase inhibitors in cancer therapy</articletitle>, <worktitle>J Natl.Cancer Inst.</worktitle> <volume>93</volume> [<number>3</number>], Seite <pages>178</pages>-<pages>193</pages>. </citation>
[92] <citation id="_bib92" published="yes" workType="Journal"><workauthor>Rudek, M. A.; Figg, W. D.; Dyer, V.; Dahut, W.; Turner, M. L.; Steinberg, S. M.; Liewehr, D. J.; Kohler, D. R.; Pluda, J. M. und Reed, E.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Phase I clinical trial of oral COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer</articletitle>, <worktitle>J.Clin.Oncol.</worktitle> <volume>19</volume> [<number>2</number>], Seite <pages>584</pages>-<pages>592</pages>. </citation>
[93] <citation id="_bib93" published="yes" workType="Misc"><workauthor>Bayer Pharmaceutical Division</workauthor>:<worktitle>Bayer Halts Clinical Trials Evaluating MMPI</worktitle>.URL: <url href="www.bayerpharma-na.com/news/co0221.asp" type="URL">www.bayerpharma-na.com/news/co0221.asp</url> </citation>
[94] <citation id="_bib94" published="yes" workType="Journal"><workauthor>Brown, P. D. und Giavazzi, R.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Matrix metalloproteinase inhibition: a review of anti-tumour activity</articletitle>, <worktitle>Ann.Oncol.</worktitle> <volume>6</volume> [<number>10</number>], Seite <pages>967</pages>-<pages>974</pages>. </citation>
[95] <citation id="_bib95" published="yes" workType="Journal"><workauthor>Yip, D.; Ahmad, A.; Karapetis, C. S.; Hawkins, C. A. und Harper, P. G.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Matrix metalloproteinase inhibitors: applications in oncology</articletitle>, <worktitle>Invest New Drugs</worktitle> <volume>17</volume> [<number>4</number>], Seite <pages>387</pages>-<pages>399</pages>. </citation>
[96] <citation id="_bib96" published="yes" workType="Journal"><workauthor>Heath, E. I. und Grochow, L. B.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Clinical potential of matrix metalloprotease inhibitors in cancer therapy</articletitle>, <worktitle>Drugs</worktitle> <volume>59</volume> [<number>5</number>], Seite <pages>1043</pages>-<pages>1055</pages>. </citation>
[97] <citation id="_bib97" published="yes" workType="Journal"><workauthor>Coussens, L. M.; Fingleton, B. und Matrisian, L. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Matrix metalloproteinase inhibitors and cancer: trials and tribulations</articletitle>, <worktitle>Science</worktitle> <volume>295</volume> [<number>5564</number>], Seite <pages>2387</pages>-<pages>2392</pages>. </citation>
[98] <citation id="_bib98" published="yes" workType="Journal"><workauthor>Aparicio, T.; Kermorgant, S.; Dessirier, V.; Lewin, M. J. und Lehy, T.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats</articletitle>, <worktitle>Carcinogenesis</worktitle> <volume>20</volume> [<number>8</number>], Seite <pages>1445</pages>-<pages>1451</pages>. </citation>
[99] <citation id="_bib99" published="yes" workType="Journal"><workauthor>Low, J. A.; Johnson, M. D.; Bone, E. A. und Dickson, R. B.</workauthor> (<pubdate>1996</pubdate>): <articletitle>The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>2</volume> [<number>7</number>], Seite <pages>1207</pages>-<pages>1214</pages>. </citation>
[100] <citation id="_bib100" published="yes" workType="Journal"><workauthor>Eccles, S. A.; Box, G. M.; Court, W. J.; Bone, E. A.; Thomas, W. und Brown, P. D.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94)</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>56</volume> [<number>12</number>], Seite <pages>2815</pages>-<pages>2822</pages>. </citation>
[101] <citation id="_bib101" published="yes" workType="Journal"><workauthor>Watson, S. A.; Morris, T. M.; Robinson, G.; Crimmin, M. J.; Brown, P. D. und Hardcastle, J. D.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>55</volume> [<number>16</number>], Seite <pages>3629</pages>-<pages>3633</pages>. </citation>
[102] <citation id="_bib102" published="yes" workType="Journal"><workauthor>Taraboletti, G.; Garofalo, A.; Belotti, D.; Drudis, T.; Borsotti, P.; Scanziani, E.; Brown, P. D. und Giavazzi, R.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases</articletitle>, <worktitle>J.Natl.Cancer Inst.</worktitle> <volume>87</volume> [<number>4</number>], Seite <pages>293</pages>-<pages>298</pages>. </citation>
[103] <citation id="_bib103" published="yes" workType="Journal"><workauthor>Chirivi, R. G.; Garofalo, A.; Crimmin, M. J.; Bawden, L. J.; Stoppacciaro, A.; Brown, P. D. und Giavazzi, R.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor</articletitle>, <worktitle>Int.J.Cancer</worktitle> <volume>58</volume> [<number>3</number>], Seite <pages>460</pages>-<pages>464</pages>. </citation>
[104] <citation id="_bib104" published="yes" workType="Journal"><workauthor>Jimenez, R. E.; Hartwig, W.; Antoniu, B. A.; Compton, C. C.; Warshaw, A. L. und Fernandez-Del Castillo, C.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control</articletitle>, <worktitle>Ann.Surg.</worktitle> <volume>231</volume> [<number>5</number>], Seite <pages>644</pages>-<pages>654</pages>. </citation>
[105] <citation id="_bib105" published="yes" workType="Journal"><workauthor>Erba, E.; Ronzoni, S.; Bassano, L.; Giavazzi, R. und D'Incalci, M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells</articletitle>, <worktitle>Ann.Oncol.</worktitle> <volume>10</volume> [<number>5</number>], Seite <pages>589</pages>-<pages>591</pages>. </citation>
[106] <citation id="_bib106" published="yes" workType="Journal"><workauthor>Tonn, J. C.; Kerkau, S.; Hanke, A.; Bouterfa, H.; Mueller, J. G.; Wagner, S.; Vince, G. H. und Roosen, K.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro</articletitle>, <worktitle>Int.J.Cancer</worktitle> <volume>80</volume> [<number>5</number>], Seite <pages>764</pages>-<pages>772</pages>. </citation>
[107] <citation id="_bib107" published="yes" workType="Journal"><workauthor>Stonelake, P. S.; Jones, C. E.; Neoptolemos, J. P. und Baker, P. R.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Proteinase inhibitors reduce basement membrane degradation by human breast cancer cell lines</articletitle>, <worktitle>Br.J.Cancer</worktitle> <volume>75</volume> [<number>7</number>], Seite <pages>951</pages>-<pages>959</pages>. </citation>
[108] <citation id="_bib108" published="yes" workType="Journal"><workauthor>Parvathy, S.; Oppong, S. Y.; Karran, E. H.; Buckle, D. R.; Turner, A. J. und Hooper, N. M.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer</articletitle>, <worktitle>Biochem.J.</worktitle> <volume>327 ( Pt 1)</volume>, Seite <pages>37</pages>-<pages>43</pages>. </citation>
[109] <citation id="_bib109" published="yes" workType="Journal"><workauthor>Beattie, G. J. und Smyth, J. F.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>4</volume> [<number>8</number>], Seite <pages>1899</pages>-<pages>1902</pages>. </citation>
[110] <citation id="_bib110" published="yes" workType="Journal"><workauthor>Bramhall, S. R.; Hallissey, M. T.; Whiting, J.; Scholefield, J.; Tierney, G.; Stuart, R. C.; Hawkins, R. E.; McCulloch, P.; Maughan, T.; Brown, P. D.; Baillet, M. und Fielding, J. W.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial</articletitle>, <worktitle>Br J Cancer</worktitle> <volume>86</volume> [<number>12</number>], Seite <pages>1864</pages>-<pages>1870</pages>. </citation>
[111] <citation id="_bib111" published="yes" workType="Journal"><workauthor>Lokeshwar, B. L.; Selzer, M. G.; Zhu, B. Q.; Block, N. L. und Golub, L. M.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>98</volume> [<number>2</number>], Seite <pages>297</pages>-<pages>309</pages>. </citation>
[112] <citation id="_bib112" published="yes" workType="Misc"><workauthor>Saad, F. Klotz L. Babaian R. Lacombe L. Champagne P. andDupont É.</workauthor>:<worktitle>Phase I/II trial on Æ-941 (Neovastat) in patients with metastatic
refractory prostate cancer.</worktitle>.URL: <url href="www.aeterna.com/aeterna/ang/search/search.asp?P=1&amp;str=prostate" type="URL">www.aeterna.com/aeterna/ang/search/search.asp?P=1&amp;str=prostate</url> </citation>
[113] <citation id="_bib113" published="yes" workType="Misc"><workauthor>Wilding, G., Small, E, and Collier, M.</workauthor> (15-5-1999):<worktitle>A phase I pharmacokinetic evaluation of the matrix metalloprotease (MMP) inhibitor AG3340 in combination with mitoxantrone and prednisone in patients with advanced prostate cancer</worktitle> <address>Atlanta, GA</address>.URL: <url href="www.conference-cast.com/asco/abstract_frame.htm" type="URL">www.conference-cast.com/asco/abstract_frame.htm</url> </citation>
[114] <citation id="_bib114" published="yes" workType="Misc"><workauthor>Boasberg, P., Harbaugh, Eisenberger, M., Harris, J, Langleben, A., Ahmann, F., Roth.B., Berkheimer, M., and Rasmussen, H.</workauthor>:<worktitle>Marimastat in patients with hormone refractory prostate cancer: a dose-finding study.</worktitle> (<volume>Abstr. No. 1126</volume>).URL: <url href="www.conference-cast.com/asco/abstract_frame.htm" type="URL">www.conference-cast.com/asco/abstract_frame.htm</url> </citation>
[115] <citation id="_bib115" published="yes" workType="Misc"><workauthor>Eisenberger, M., Sinibaldi, V., Laufer, M., Carducci, M., Miller, C., Boasberg, P., Ahmann, F., and Roth.B.</workauthor> (2000):<worktitle>Phase-I/+ Pharmacokinetic Evaluation of Marimastat in Patients (PTS) with Advanced Prostate Cancer (PC): Identificataion of the Biologically Acitve Dose.</worktitle> (<volume>19</volume>). </citation>
[116] <citation id="_bib116" published="yes" workType="Journal"><workauthor>Stone, K. R.; Mickey, D. D.; Wunderli, H.; Mickey, G. H. und Paulson, D. F.</workauthor> (<pubdate>1978</pubdate>): <articletitle>Isolation of a human prostate carcinoma cell line (DU 145)</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>21</volume> [<number>3</number>], Seite <pages>274</pages>-<pages>281</pages>. </citation>
[117] <citation id="_bib117" published="yes" workType="Book"><workauthor>Horoszewicz, J. S; Leong, S S.; Chu, T. M.; Wajsman, Z. L.; Friedman, M.; Papsidero, L.; Kim, U.; Chai, L. S.; Kakati, S.; Arya, S. k. und Sandberg, A. A.</workauthor> (<pubdate>1980</pubdate>): <articletitle>The LNCaP Cell Line - A New Model for Studies on Human Prostatic Carcinoma</articletitle>, <editor>Murphy, G. P.</editor>, <worktitle>Models for Prostate Cancer</worktitle> , Seite <pages>115</pages>-<pages>132</pages>, <address>New York</address>. </citation>
[118] <citation id="_bib118" published="yes" workType="Book"><workauthor>Kaighn, M. E.; Lechner, J. F.; Babcock, M. S.; Marnell, M.; Ohnuki, Y. und Narayan, K. S.</workauthor> (<pubdate>1980</pubdate>): <articletitle>The Pasadena Cell Lines</articletitle>, <editor>Murphy, G. P.</editor>, <worktitle>Models for prostate Cancer</worktitle> , Seite <pages>85</pages>-<pages>109</pages>, <address>New York</address>. </citation>
[119] <citation id="_bib119" published="yes" workType="Book"><workauthor>Lubaroff, D. M.; Canfield, L. und Reynolds, C. W.</workauthor> (<pubdate>1980</pubdate>): <articletitle>The Dunning Tumors</articletitle>, <editor>Murphy, G. P.</editor>, <worktitle>Models for Prostate Cancer</worktitle> , Seite <pages>243</pages>-<pages>263</pages>, <address>New York</address>. </citation>
[120] <citation id="_bib120" published="yes" workType="Journal"><workauthor>Lucia, M. S.; Bostwick, D. G.; Bosland, M.; Cockett, A. T.; Knapp, D. W.; Leav, I.; Pollard, M.; Rinker, Schaeffer C.; Shirai, T. und Watkins, B. A.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Workgroup I: rodent models of prostate cancer</articletitle>, <worktitle>Prostate</worktitle> <volume>36</volume> [<number>1</number>], Seite <pages>49</pages>-<pages>55</pages>. </citation>
[121] <citation id="_bib121" published="yes" workType="Journal"><workauthor>Wikstrom, P.; Lindh, G.; Bergh, A. und Damber, J. E.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Alterations of transforming growth factor beta1 (TGF-beta1) and TGFbeta receptor expressions with progression in Dunning rat prostatic adenocarcinoma sublines</articletitle>, <worktitle>Urol.Res.</worktitle> <volume>27</volume> [<number>3</number>], Seite <pages>185</pages>-<pages>193</pages>. </citation>
[122] <citation id="_bib122" published="yes" workType="Journal"><workauthor>Blount, L. V. und Cooke, D. B., III</workauthor> (<pubdate>1996</pubdate>): <articletitle>Point mutations in the Ki-ras2 gene of codon 12 in the Dunning R-3327 Prostatic Adenocarcinoma system</articletitle>, <worktitle>Prostate</worktitle> <volume>28</volume> [<number>1</number>], Seite <pages>44</pages>-<pages>50</pages>. </citation>
[123] <citation id="_bib123" published="yes" workType="Journal"><workauthor>Rao, B. R.; Slotman, B. J.; Geldof, A. A. und Perez, C. A.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Radiation sensitivity of Copenhagen rat prostatic carcinoma (R3327-AT and R3327-MATLyLu)</articletitle>, <worktitle>Int.J.Radiat.Oncol.Biol.Phys.</worktitle> <volume>20</volume> [<number>5</number>], Seite <pages>981</pages>-<pages>985</pages>. </citation>
[124] <citation id="_bib124" published="yes" workType="Journal"><workauthor>Smolev, J. K.; Heston, W. D.; Scott, W. W. und Coffey, D. S.</workauthor> (<pubdate>1977</pubdate>): <articletitle>Characterization of the Dunning R3327H prostatic adenocarcinoma: an appropriate animal model for prostatic cancer</articletitle>, <worktitle>Cancer Treat.Rep.</worktitle> <volume>61</volume> [<number>2</number>], Seite <pages>273</pages>-<pages>287</pages>. </citation>
[125] <citation id="_bib125" published="yes" workType="Journal"><workauthor>Tennant, T. R.; Kim, H.; Sokoloff, M. und Rinker-Schaeffer, C. W.</workauthor> (<pubdate>2000</pubdate>): <articletitle>The Dunning model</articletitle>, <worktitle>Prostate</worktitle> <volume>43</volume> [<number>4</number>], Seite <pages>295</pages>-<pages>302</pages>. </citation>
[126] <citation id="_bib126" published="yes" workType="Journal"><workauthor>Garde, S. V.; Sheth, A. R.; Porter, A. T. und Pienta, K. J.</workauthor> (<pubdate>1993</pubdate>): <articletitle>A comparative study on expression of prostatic inhibin peptide, prostate acid phosphatase and prostate specific antigen in androgen independent human and rat prostate carcinoma cell lines</articletitle>, <worktitle>Cancer Lett.</worktitle> <volume>70</volume> [<number>3</number>], Seite <pages>159</pages>-<pages>166</pages>. </citation>
[127] <citation id="_bib127" published="yes" workType="Journal"><workauthor>Isaacs, J. T.</workauthor> (<pubdate>1996</pubdate>): <articletitle>The R-3327 System of Rat Prostatic Cancers</articletitle>, <worktitle>Urologic Oncology</worktitle> <volume>2</volume> [<number>4</number>], Seite <pages>115</pages>-<pages>116</pages>. </citation>
[128] <citation id="_bib128" published="yes" workType="Journal"><workauthor>Isaacs, J. T.; Yu, G. W. und Coffey, D. S.</workauthor> (<pubdate>1981</pubdate>): <articletitle>The characterization of a newly identified, highly metastatic variety of Dunning R 3327 rat prostatic adenocarcinoma system: the MAT LyLu tumor</articletitle>, <worktitle>Invest Urol.</worktitle> <volume>19</volume> [<number>1</number>], Seite <pages>20</pages>-<pages>23</pages>. </citation>
[129] <citation id="_bib129" published="yes" workType="Journal"><workauthor>Haggstrom, S.; Wikstrom, P.; Bergh, A. und Damber, J. E.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Expression of vascular endothelial growth factor and its receptors in the rat ventral prostate and Dunning R3327 PAP adenocarcinoma before and after castration</articletitle>, <worktitle>Prostate</worktitle> <volume>36</volume> [<number>2</number>], Seite <pages>71</pages>-<pages>79</pages>. </citation>
[130] <citation id="_bib130" published="yes" workType="Journal"><workauthor>Steiner, M. S.; Zhou, Z. Z.; Tonb, D. C. und Barrack, E. R.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Expression of transforming growth factor-beta 1 in prostate cancer</articletitle>, <worktitle>Endocrinology</worktitle> <volume>135</volume> [<number>5</number>], Seite <pages>2240</pages>-<pages>2247</pages>. </citation>
[131] <citation id="_bib131" published="yes" workType="Journal"><workauthor>Isaacs, J. T.; Isaacs, W. B.; Feitz, W. F. und Scheres, J.</workauthor> (<pubdate>1986</pubdate>): <articletitle>Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers</articletitle>, <worktitle>Prostate</worktitle> <volume>9</volume> [<number>3</number>], Seite <pages>261</pages>-<pages>281</pages>. </citation>
[132] <citation id="_bib132" published="yes" workType="Journal"><workauthor>Berridge, M. V.; Tan, A. S.; McCoy, K. D. und Wang, R.</workauthor> (<pubdate>1996</pubdate>): <articletitle>The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts</articletitle>, <worktitle>Biochemica</worktitle> <volume>4</volume>, Seite <pages>14</pages>-<pages>19</pages>. </citation>
[133] <citation id="_bib133" published="yes" workType="Journal"><workauthor>Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, J.; Cronise, P.; Vaigro, Wolff A. und et, al</workauthor> (<pubdate>1991</pubdate>): <articletitle>Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines</articletitle>, <worktitle>J.Natl.Cancer Inst.</worktitle> <volume>83</volume> [<number>11</number>], Seite <pages>757</pages>-<pages>766</pages>. </citation>
[134] <citation id="_bib134" published="yes" workType="Journal"><workauthor>Plumb, J. A.; Milroy, R. und Kaye, S. B.</workauthor> (<pubdate>1989</pubdate>): <articletitle>Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>49</volume> [<number>16</number>], Seite <pages>4435</pages>-<pages>4440</pages>. </citation>
[135] <citation id="_bib135" published="yes" workType="Journal"><workauthor>Romijn, J. C.; Verkoelen, C. F. und Schroeder, F. H.</workauthor> (<pubdate>1988</pubdate>): <articletitle>Application of the MTT assay to human prostate cancer cell lines in vitro: establishment of test conditions and assessment of hormone-stimulated growth and drug-induced cytostatic and cytotoxic effects</articletitle>, <worktitle>Prostate</worktitle> <volume>12</volume> [<number>1</number>], Seite <pages>99</pages>-<pages>110</pages>. </citation>
[136] <citation id="_bib136" published="yes" workType="Journal"><workauthor>Berridge, M. V. und Tan, A. S.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction</articletitle>, <worktitle>Arch.Biochem.Biophys.</worktitle> <volume>303</volume> [<number>2</number>], Seite <pages>474</pages>-<pages>482</pages>. </citation>
[137] <citation id="_bib137" published="yes" workType="Book"><workauthor>Skehan, P.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Cytotoxicity and Cell Growth Assays</articletitle>, <editor>Celis, J. E.</editor>, <worktitle>Cell Biology</worktitle> , Seite <pages>313</pages>-<pages>318</pages>, <url href="0-12-164726-9" type="ISBN">0-12-164726-9</url>. </citation>
[138] <citation id="_bib138" published="yes" workType="Journal"><workauthor>Bank, U.; Reinhold, D. und Ansorge, S.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Messung der zellulären Aktivität mit Hilfe des MTT-Farbtests</articletitle>, <worktitle>Allerg Immunol</worktitle> <volume>37</volume>, Seite <pages>119</pages>-<pages>123</pages>. </citation>
[139] <citation id="_bib139" published="yes" workType="Journal"><workauthor>Sieuwerts, A. M.; Klijn, J. G.; Peters, H. A. und Foekens, J. A.</workauthor> (<pubdate>1995</pubdate>): <articletitle>The MTT tetrazolium salt assay scrutinized: how to use this assay reliably to measure metabolic activity of cell cultures in vitro for the assessment of growth characteristics, IC50-values and cell survival</articletitle>, <worktitle>Eur.J.Clin.Chem.Clin.Biochem.</worktitle> <volume>33</volume> [<number>11</number>], Seite <pages>813</pages>-<pages>823</pages>. </citation>
[140] <citation id="_bib140" published="yes" workType="Book"><workauthor>Freshney, R. I.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Measurement of Viability and Cytotoxicity</articletitle>, <editor>Freshney, R. I.</editor>, <worktitle>Culture of animal cells</worktitle> , <edition>3</edition>. Auflage, Seite <pages>287</pages>-<pages>307</pages>. </citation>
[141] <citation id="_bib141" published="yes" workType="Book"><workauthor>Holst-Hansen, C. und Brunner, N.</workauthor> (<pubdate>1998</pubdate>): <articletitle>MTT-Cell Proliferation Assay</articletitle>, <editor>Celis, J. E.</editor>, <worktitle>Cell Biology</worktitle> , <edition>2</edition>. Auflage, Seite <pages>16</pages>-<pages>18</pages>, <url href="0-12-164726-9" type="ISBN">0-12-164726-9</url>. </citation>
[142] <citation id="_bib142" published="yes" workType="Journal"><workauthor>Ravenna, L.; Lubrano, C.; Di, Silverio F.; Vacca, A.; Felli, M. P.; Maroder, M.; D'Eramo, G.; Sciarra, F.; Frati, L.; Gulino, A. und et, al</workauthor> (<pubdate>1995</pubdate>): <articletitle>Androgenic and antiandrogenic control on epidermal growth factor, epidermal growth factor receptor, and androgen receptor expression in human prostate cancer cell line LNCaP</articletitle>, <worktitle>Prostate</worktitle> <volume>26</volume> [<number>6</number>], Seite <pages>290</pages>-<pages>298</pages>. </citation>
[143] <citation id="_bib143" published="yes" workType="Journal"><workauthor>Watson, S. A.; Morris, T. M.; Parsons, S. L.; Steele, R. J. und Brown, P. D.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model</articletitle>, <worktitle>Br.J.Cancer</worktitle> <volume>74</volume> [<number>9</number>], Seite <pages>1354</pages>-<pages>1358</pages>. </citation>
[144] <citation id="_bib144" published="yes" workType="Journal"><workauthor>Hanglow, A. C.; Lugo, A.; Walsky, R.; Finch-Arietta, M.; Lusch, L.; Visnick, M. und Fotouhi, N.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Peptides based on the conserved predomain sequence of matrix metalloproteinases inhibit human stromelysin and collagenase</articletitle>, <worktitle>Agents Actions</worktitle> <volume>39 Spec No</volume>, Seite <pages>C148</pages>-<pages>C150</pages>. </citation>
[145] <citation id="_bib145" published="yes" workType="Journal"><workauthor>Jung, K.; Nowak, L.; Lein, M.; Priem, F.; Schnorr, D. und Loening, S. A.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Matrix metalloproteinases 1 and 3, tissue inhibitor of metalloproteinase-1 and the complex of metalloproteinase-1/tissue inhibitor in plasma of patients with prostate cancer</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>74</volume> [<number>2</number>], Seite <pages>220</pages>-<pages>223</pages>. </citation>
[146] <citation id="_bib146" published="yes" workType="Journal"><workauthor>Baker, T.; Tickle, S.; Wasan, H.; Docherty, A.; Isenberg, D. und Waxman, J.</workauthor> (<pubdate>1994</pubdate>): <articletitle>Serum metalloproteinases and their inhibitors: markers for malignant potential</articletitle>, <worktitle>Br J Cancer</worktitle> <volume>70</volume> [<number>3</number>], Seite <pages>506</pages>-<pages>512</pages>. </citation>
[147] <citation id="_bib147" published="yes" workType="Misc"><workauthor>Boasberg, P., Harbaugh, B., Roth, B., Eisenberger, M., Langleben, A., Allen, R., and Rasmussen, H.</workauthor>:<worktitle>Marimastat, a novel matrix metalloproteinse inhibitor in patients with hormone-refractory prostate cancer</worktitle> (<volume>15</volume>).URL: <url href="www.asco.org/ac/1,1003,_12-002489-00_18-001996-00_19-009282-00_28-00RESULTPAGE,00.asp" type="URL">www.asco.org/ac/1,1003,_12-002489-00_18-001996-00_19-009282-00_28-00RESULTPAGE,00.asp</url> </citation>
[148] <citation id="_bib148" published="yes" workType="Journal"><workauthor>Shaffer, D. R. und Scher, H. I.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Prostate cancer: a dynamic illness with shifting targets</articletitle>, <worktitle>Lancet Oncol.</worktitle> <volume>4</volume> [<number>7</number>], Seite <pages>407</pages>-<pages>414</pages>. </citation>
[149] <citation id="_bib149" published="yes" workType="Journal"><workauthor>Matsuura, E.; Umehara, F.; Hashiguchi, T.; Fujimoto, N.; Okada, Y. und Osame, M.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis</articletitle>, <worktitle>J Neurol.Sci.</worktitle> <volume>173</volume> [<number>1</number>], Seite <pages>45</pages>-<pages>52</pages>. </citation>
[150] <citation id="_bib150" published="yes" workType="Journal"><workauthor>Zucker, S.; Hymowitz, M.; Conner, C.; Zarrabi, H. M.; Hurewitz, A. N.; Matrisian, L.; Boyd, D.; Nicolson, G. und Montana, S.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications</articletitle>, <worktitle>Ann.N.Y.Acad.Sci.</worktitle> <volume>878</volume>, Seite <pages>212</pages>-<pages>227</pages>. </citation>
[151] <citation id="_bib151" published="yes" workType="Journal"><workauthor>Jiang, Y.; Wang, M.; Celiker, M. Y.; Liu, Y. E.; Sang, Q. X.; Goldberg, I. D. und Shi, Y. E.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>61</volume> [<number>6</number>], Seite <pages>2365</pages>-<pages>2370</pages>. </citation>
[152] <citation id="_bib152" published="yes" workType="Journal"><workauthor>Hanemaaijer, R.; Verheijen, J. H.; Maguire, T. M.; Visser, H.; Toet, K.; McDermott, E.; O'Higgins, N. und Duffy, M. J.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>86</volume> [<number>2</number>], Seite <pages>204</pages>-<pages>207</pages>. </citation>
[153] <citation id="_bib153" published="yes" workType="Journal"><workauthor>Kuniyasu, H.; Troncoso, P.; Johnston, D.; Bucana, C. D.; Tahara, E.; Fidler, I. J. und Pettaway, C. A.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Relative expression of type IV collagenae, E-cadherin, and vascular endothelial growth factor/vascular permeability factor in prostatectomy specimens distinguishes organ-confined from pathologically advanced prostate cancers [In Process Citation]</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>6</volume> [<number>6</number>], Seite <pages>2295</pages>-<pages>2308</pages>. </citation>
[154] <citation id="_bib154" published="yes" workType="Journal"><workauthor>Nakanishi, K.; Kawai, T.; Sato, H.; Aida, S.; Kasamatsu, H.; Aurues, T. und Ikeda, T.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract</articletitle>, <worktitle>Hum.Pathol.</worktitle> <volume>31</volume> [<number>2</number>], Seite <pages>193</pages>-<pages>200</pages>. </citation>
[155] <citation id="_bib155" published="yes" workType="Journal"><workauthor>Maatta, M.; Soini, Y.; Liakka, A. und Autio-Harmainen, H.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>6</volume> [<number>7</number>], Seite <pages>2726</pages>-<pages>2734</pages>. </citation>
[156] <citation id="_bib156" published="yes" workType="Journal"><workauthor>Upadhyay, J.; Shekarriz, B.; Nemeth, J. A.; Dong, Z.; Cummings, G. D.; Fridman, R.; Sakr, W.; Grignon, D. J. und Cher, M. L.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>5</volume> [<number>12</number>], Seite <pages>4105</pages>-<pages>4110</pages>. </citation>
[157] <citation id="_bib157" published="yes" workType="Journal"><workauthor>Vaisanen, A.; Kallioinen, M.; Taskinen, P. J. und Turpeenniemi, Hujanen T.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma</articletitle>, <worktitle>J.Pathol.</worktitle> <volume>186</volume> [<number>1</number>], Seite <pages>51</pages>-<pages>58</pages>. </citation>
[158] <citation id="_bib158" published="yes" workType="Journal"><workauthor>Bando, E.; Yonemura, Y.; Endou, Y.; Sasaki, T.; Taniguchi, K.; Fujita, H.; Fushida, S.; Fujimura, T.; Nishimura, G.; Miwa, K. und Seiki, M.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Immunohistochemical study of MT-MMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis</articletitle>, <worktitle>Oncol.Rep.</worktitle> <volume>5</volume> [<number>6</number>], Seite <pages>1483</pages>-<pages>1488</pages>. </citation>
[159] <citation id="_bib159" published="yes" workType="Journal"><workauthor>Etoh, T.; Inoue, H.; Yoshikawa, Y.; Barnard, G. F.; Kitano, S. und Mori, M.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness</articletitle>, <worktitle>Gut</worktitle> <volume>47</volume> [<number>1</number>], Seite <pages>50</pages>-<pages>56</pages>. </citation>
[160] <citation id="_bib160" published="yes" workType="Journal"><workauthor>Moser, P. L.; Kieback, D. G.; Hefler, L.; Tempfer, C.; Neunteufel, W. und Gitsch, G.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer</articletitle>, <worktitle>Anticancer Res.</worktitle> <volume>19</volume> [<number>5C</number>], Seite <pages>4391</pages>-<pages>4393</pages>. </citation>
[161] <citation id="_bib161" published="yes" workType="Journal"><workauthor>Yamashita, K.; Tanaka, Y.; Mimori, K.; Inoue, H. und Mori, M.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>110</volume> [<number>2</number>], Seite <pages>201</pages>-<pages>207</pages>. </citation>
[162] <citation id="_bib162" published="yes" workType="Journal"><workauthor>Chenard, M. P.; O'Siorain, L.; Shering, S.; Rouyer, N.; Lutz, Y.; Wolf, C.; Basset, P.; Bellocq, J. P. und Duffy, M. J.</workauthor> (<pubdate>1996</pubdate>): <articletitle>High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>69</volume> [<number>6</number>], Seite <pages>448</pages>-<pages>451</pages>. </citation>
[163] <citation id="_bib163" published="yes" workType="Journal"><workauthor>Jones, J. L.; Glynn, P. und Walker, R. A.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas</articletitle>, <worktitle>J Pathol.</worktitle> <volume>189</volume> [<number>2</number>], Seite <pages>161</pages>-<pages>168</pages>. </citation>
[164] <citation id="_bib164" published="yes" workType="Journal"><workauthor>Powe, D. G.; Brough, J. L.; Carter, G. I.; Bailey, E. M.; Stetler-Stevenson, W. G.; Turner, D. R. und Hewitt, R. E.</workauthor> (<pubdate>1997</pubdate>): <articletitle>TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma</articletitle>, <worktitle>Br J Cancer</worktitle> <volume>75</volume> [<number>11</number>], Seite <pages>1678</pages>-<pages>1683</pages>. </citation>
[165] <citation id="_bib165" published="yes" workType="Journal"><workauthor>Joo, Y. E.; Seo, K. S.; Kim, H. S.; Rew, J. S.; Park, C. S. und Kim, S. J.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Expression of tissue inhibitors of metalloproteinases (TIMPs) in gastric cancer</articletitle>, <worktitle>Dig.Dis.Sci</worktitle> <volume>45</volume> [<number>1</number>], Seite <pages>114</pages>-<pages>121</pages>. </citation>
[166] <citation id="_bib166" published="yes" workType="Journal"><workauthor>Michael, M.; Babic, B.; Khokha, R.; Tsao, M.; Ho, J.; Pintilie, M.; Leco, K.; Chamberlain, D. und Shepherd, F. A.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer</articletitle>, <worktitle>J Clin.Oncol.</worktitle> <volume>17</volume> [<number>6</number>], Seite <pages>1802</pages>-<pages>1808</pages>. </citation>
[167] <citation id="_bib167" published="yes" workType="Journal"><workauthor>Kossakowska, A. E.; Urbanski, S. J. und Edwards, D. R.</workauthor> (<pubdate>1991</pubdate>): <articletitle>Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas</articletitle>, <worktitle>Blood</worktitle> <volume>77</volume> [<number>11</number>], Seite <pages>2475</pages>-<pages>2481</pages>. </citation>
[168] <citation id="_bib168" published="yes" workType="Journal"><workauthor>McCarthy, K.; Maguire, T.; McGreal, G.; McDermott, E.; O'Higgins, N. und Duffy, M. J.</workauthor> (<pubdate>1999</pubdate>): <articletitle>High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>84</volume> [<number>1</number>], Seite <pages>44</pages>-<pages>48</pages>. </citation>
[169] <citation id="_bib169" published="yes" workType="Journal"><workauthor>Zeng, Z. S.; Cohen, A. M.; Zhang, Z. F.; Stetler-Stevenson, W. und Guillem, J. G.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>1</volume> [<number>8</number>], Seite <pages>899</pages>-<pages>906</pages>. </citation>
[170] <citation id="_bib170" published="yes" workType="Journal"><workauthor>Holten-Andersen, M. N.; Stephens, R. W.; Nielsen, H. J.; Murphy, G.; Christensen, I. J.; Stetler-Stevenson, W. und Brunner, N.</workauthor> (<pubdate>2000</pubdate>): <articletitle>High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer</articletitle>, <worktitle>Clin.Cancer Res.</worktitle> <volume>6</volume> [<number>11</number>], Seite <pages>4292</pages>-<pages>4299</pages>. </citation>
[171] <citation id="_bib171" published="yes" workType="Journal"><workauthor>Ylisirnio, S.; Hoyhtya, M. und Turpeenniemi-Hujanen, T.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker</articletitle>, <worktitle>Anticancer Res.</worktitle> <volume>20</volume> [<number>2B</number>], Seite <pages>1311</pages>-<pages>1316</pages>. </citation>
[172] <citation id="_bib172" published="yes" workType="Journal"><workauthor>Davidson, B.; Goldberg, I.; Kopolovic, J.; Lerner-Geva, L.; Gotlieb, W. H.; Ben Baruch, G. und Reich, R.</workauthor> (<pubdate>1999</pubdate>): <articletitle>MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization</articletitle>, <worktitle>Gynecol.Oncol.</worktitle> <volume>73</volume> [<number>3</number>], Seite <pages>372</pages>-<pages>382</pages>. </citation>
[173] <citation id="_bib173" published="yes" workType="Journal"><workauthor>Tutton, M. G.; George, M. L.; Eccles, S. A.; Burton, S.; Swift, R. I. und Abulafi, A. M.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>107</volume> [<number>4</number>], Seite <pages>541</pages>-<pages>550</pages>. </citation>
[174] <citation id="_bib174" published="yes" workType="Journal"><workauthor>Lein, M.; Jung, K.; Laube, C.; Hubner, T.; Winkelmann, B.; Stephan, C.; Hauptmann, S.; Rudolph, B.; Schnorr, D. und Loening, S. A.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>85</volume> [<number>6</number>], Seite <pages>801</pages>-<pages>804</pages>. </citation>
[175] <citation id="_bib175" published="yes" workType="Journal"><workauthor>Giannelli, G.; Erriquez, R.; Fransvea, E.; Daniele, A.; Trerotoli, P.; Schittulli, F.; Grano, M.; Quaranta, M. und Antonaci, S.</workauthor> (<pubdate>2004</pubdate>): <articletitle>Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>109</volume> [<number>5</number>], Seite <pages>782</pages>-<pages>785</pages>. </citation>
[176] <citation id="_bib176" published="yes" workType="Journal"><workauthor>Rudolph-Owen, L. A.; Chan, R.; Muller, W. J. und Matrisian, L. M.</workauthor> (<pubdate>1998</pubdate>): <articletitle>The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>58</volume> [<number>23</number>], Seite <pages>5500</pages>-<pages>5506</pages>. </citation>
[177] <citation id="_bib177" published="yes" workType="Journal"><workauthor>Witty, J. P.; Wright, J. H. und Matrisian, L. M.</workauthor> (<pubdate>1995</pubdate>): <articletitle>Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development</articletitle>, <worktitle>Mol.Biol.Cell</worktitle> <volume>6</volume> [<number>10</number>], Seite <pages>1287</pages>-<pages>1303</pages>. </citation>
[178] <citation id="_bib178" published="yes" workType="Journal"><workauthor>Albini, A.; Melchiori, A.; Santi, L.; Liotta, L. A.; Brown, P. D. und Stetler, Stevenson WG</workauthor> (<pubdate>1991</pubdate>): <articletitle>Tumor cell invasion inhibited by TIMP-2 [see comments]</articletitle>, <worktitle>J.Natl.Cancer Inst.</worktitle> <volume>83</volume> [<number>11</number>], Seite <pages>775</pages>-<pages>779</pages>. </citation>
[179] <citation id="_bib179" published="yes" workType="Journal"><workauthor>Baker, A. H.; George, S. J.; Zaltsman, A. B.; Murphy, G. und Newby, A. C.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3</articletitle>, <worktitle>Br.J.Cancer</worktitle> <volume>79</volume> [<number>9-10</number>], Seite <pages>1347</pages>-<pages>1355</pages>. </citation>
[180] <citation id="_bib180" published="yes" workType="Journal"><workauthor>Buck, T. B.; Yoshiji, H.; Harris, S. R.; Bunce, O. R. und Thorgeirsson, U. P.</workauthor> (<pubdate>1999</pubdate>): <articletitle>The effects of sustained elevated levels of circulating tissue inhibitor of metalloproteinases-1 on the development of breast cancer in mice</articletitle>, <worktitle>Ann.N Y.Acad.Sci</worktitle> <volume>878</volume>, Seite <pages>732</pages>-<pages>735</pages>. </citation>
[181] <citation id="_bib181" published="yes" workType="Journal"><workauthor>Guedez, L.; McMarlin, A. J.; Kingma, D. W.; Bennett, T. A.; Stetler-Stevenson, M. und Stetler-Stevenson, W. G.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis</articletitle>, <worktitle>Am.J Pathol.</worktitle> <volume>158</volume> [<number>4</number>], Seite <pages>1207</pages>-<pages>1215</pages>. </citation>
[182] <citation id="_bib182" published="yes" workType="Journal"><workauthor>Yoshiji, H.; Buck, T. B.; Harris, S. R.; Ritter, L. M.; Lindsay, C. K. und Thorgeirsson, U. P.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Stimulatory effect of endogenous tissue inhibitor of metalloproteinases-1 (TIMP-1) overexpression on type IV collagen and laminin gene expression in rat mammary carcinoma cells</articletitle>, <worktitle>Biochem.Biophys.Res.Commun.</worktitle> <volume>247</volume> [<number>3</number>], Seite <pages>605</pages>-<pages>609</pages>. </citation>
[183] <citation id="_bib183" published="yes" workType="Journal"><workauthor>Gross, J. und Lapiere, C. M.</workauthor> (<pubdate>1962</pubdate>): <articletitle>Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay</articletitle>, <worktitle>Proc.Natl.Acad.Sci.U.S.A</worktitle> <volume>48</volume>, Seite <pages>1014</pages>-<pages>1022</pages>. </citation>
[184] <citation id="_bib184" published="yes" workType="Journal"><workauthor>Cheng, L.; Mantile, G.; Pauly, R.; Nater, C.; Felici, A.; Monticone, R.; Bilato, C.; Gluzband, Y. A.; Crow, M. T.; Stetler, Stevenson W. und Capogrossi, M. C.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Adenovirus-mediated gene transfer of the human tissue inhibitor of metalloproteinase-2 blocks vascular smooth muscle cell invasiveness in vitro and modulates neointimal development in vivo</articletitle>, <worktitle>Circulation</worktitle> <volume>98</volume> [<number>20</number>], Seite <pages>2195</pages>-<pages>2201</pages>. </citation>
[185] <citation id="_bib185" published="yes" workType="Journal"><workauthor>Melchiori, A.; Albini, A.; Ray, J. M. und Stetler-Stevenson, W. G.</workauthor> (<pubdate>1992</pubdate>): <articletitle>Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>52</volume> [<number>8</number>], Seite <pages>2353</pages>-<pages>2356</pages>. </citation>
[186] <citation id="_bib186" published="yes" workType="Journal"><workauthor>Itoh, T.; Tanioka, M.; Yoshida, H.; Yoshioka, T.; Nishimoto, H. und Itohara, S.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Reduced angiogenesis and tumor progression in gelatinase A-deficient mice</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>58</volume> [<number>5</number>], Seite <pages>1048</pages>-<pages>1051</pages>. </citation>
[187] <citation id="_bib187" published="yes" workType="Journal"><workauthor>Nabeshima, K.; Inoue, T.; Shimao, Y.; Kataoka, H. und Koono, M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets</articletitle>, <worktitle>Histol.Histopathol.</worktitle> <volume>14</volume> [<number>4</number>], Seite <pages>1183</pages>-<pages>1197</pages>. </citation>
[188] <citation id="_bib188" published="yes" workType="Journal"><workauthor>Nabeshima, K.; Inoue, T.; Shimao, Y.; Okada, Y.; Itoh, Y.; Seiki, M. und Koono, M.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>60</volume> [<number>13</number>], Seite <pages>3364</pages>-<pages>3369</pages>. </citation>
[189] <citation id="_bib189" published="yes" workType="Journal"><workauthor>Legrand, C.; Gilles, C.; Zahm, J. M.; Polette, M.; Buisson, A. C.; Kaplan, H.; Birembaut, P. und Tournier, J. M.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling</articletitle>, <worktitle>J Cell Biol.</worktitle> <volume>146</volume> [<number>2</number>], Seite <pages>517</pages>-<pages>529</pages>. </citation>
[190] <citation id="_bib190" published="yes" workType="Journal"><workauthor>Moses, M. A.</workauthor> (<pubdate>1997</pubdate>): <articletitle>The regulation of neovascularization of matrix metalloproteinases and their inhibitors</articletitle>, <worktitle>Stem.Cells</worktitle> <volume>15</volume> [<number>3</number>], Seite <pages>180</pages>-<pages>189</pages>. </citation>
[191] <citation id="_bib191" published="yes" workType="Journal"><workauthor>Yu, Q. und Stamenkovic, I.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis</articletitle>, <worktitle>Genes Dev.</worktitle> <volume>14</volume> [<number>2</number>], Seite <pages>163</pages>-<pages>176</pages>. </citation>
[192] <citation id="_bib192" published="yes" workType="Journal"><workauthor>Bergers, G.; Brekken, R.; McMahon, G.; Vu, T. H.; Itoh, T.; Tamaki, K.; Tanzawa, K.; Thorpe, P.; Itohara, S.; Werb, Z. und Hanahan, D.</workauthor> (<pubdate>2000</pubdate>): <articletitle>Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis</articletitle>, <worktitle>Nat.Cell Biol.</worktitle> <volume>2</volume> [<number>10</number>], Seite <pages>737</pages>-<pages>744</pages>. </citation>
[193] <citation id="_bib193" published="yes" workType="Journal"><workauthor>Cornelius, L. A.; Nehring, L. C.; Harding, E.; Bolanowski, M.; Welgus, H. G.; Kobayashi, D. K.; Pierce, R. A. und Shapiro, S. D.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Matrix metalloproteinases generate angiostatin: effects on neovascularization</articletitle>, <worktitle>J.Immunol.</worktitle> <volume>161</volume> [<number>12</number>], Seite <pages>6845</pages>-<pages>6852</pages>. </citation>
[194] <citation id="_bib194" published="yes" workType="Journal"><workauthor>Fernandez, H. A.; Kallenbach, K.; Seghezzi, G.; Grossi, E.; Colvin, S.; Schneider, R.; Mignatti, P. und Galloway, A.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Inhibition of endothelial cell migration by gene transfer of tissue inhibitor of metalloproteinases-1</articletitle>, <worktitle>J Surg.Res.</worktitle> <volume>82</volume> [<number>2</number>], Seite <pages>156</pages>-<pages>162</pages>. </citation>
[195] <citation id="_bib195" published="yes" workType="Journal"><workauthor>Murphy, A. N.; Unsworth, E. J. und Stetler-Stevenson, W. G.</workauthor> (<pubdate>1993</pubdate>): <articletitle>Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation</articletitle>, <worktitle>J Cell Physiol</worktitle> <volume>157</volume> [<number>2</number>], Seite <pages>351</pages>-<pages>358</pages>. </citation>
[196] <citation id="_bib196" published="yes" workType="Journal"><workauthor>Anand-Apte, B.; Pepper, M. S.; Voest, E.; Montesano, R.; Olsen, B.; Murphy, G.; Apte, S. S. und Zetter, B.</workauthor> (<pubdate>1997</pubdate>): <articletitle>Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3</articletitle>, <worktitle>Invest Ophthalmol.Vis.Sci</worktitle> <volume>38</volume> [<number>5</number>], Seite <pages>817</pages>-<pages>823</pages>. </citation>
[197] <citation id="_bib197" published="yes" workType="Journal"><workauthor>Yoshiji, H.; Harris, S. R.; Raso, E.; Gomez, D. E.; Lindsay, C. K.; Shibuya, M.; Sinha, C. C. und Thorgeirsson, U. P.</workauthor> (<pubdate>1998</pubdate>): <articletitle>Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression</articletitle>, <worktitle>Int.J Cancer</worktitle> <volume>75</volume> [<number>1</number>], Seite <pages>81</pages>-<pages>87</pages>. </citation>
[198] <citation id="_bib198" published="yes" workType="Journal"><workauthor>Yamada, E.; Tobe, T.; Yamada, H.; Okamoto, N.; Zack, D. J.; Werb, Z.; Soloway, P. D. und Campochiaro, P. A.</workauthor> (<pubdate>2001</pubdate>): <articletitle>TIMP-1 promotes VEGF-induced neovascularization in the retina</articletitle>, <worktitle>Histol.Histopathol.</worktitle> <volume>16</volume> [<number>1</number>], Seite <pages>87</pages>-<pages>97</pages>. </citation>
[199] <citation id="_bib199" published="yes" workType="Journal"><workauthor>Newell, K. J.; Matrisian, L. M. und Driman, D. K.</workauthor> (<pubdate>2002</pubdate>): <articletitle>Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis</articletitle>, <worktitle>Mol.Carcinog.</worktitle> <volume>34</volume> [<number>2</number>], Seite <pages>59</pages>-<pages>63</pages>. </citation>
[200] <citation id="_bib200" published="yes" workType="Journal"><workauthor>Yamamoto, H.; Iku, S.; Adachi, Y.; Imsumran, A.; Taniguchi, H.; Nosho, K.; Min, Y.; Horiuchi, S.; Yoshida, M.; Itoh, F. und Imai, K.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer</articletitle>, <worktitle>J Pathol.</worktitle> <volume>199</volume> [<number>2</number>], Seite <pages>176</pages>-<pages>184</pages>. </citation>
[201] <citation id="_bib201" published="yes" workType="Journal"><workauthor>Baker, E. A. und Leaper, D. J.</workauthor> (<pubdate>2003</pubdate>): <articletitle>The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology</articletitle>, <worktitle>Eur.J Cancer</worktitle> <volume>39</volume> [<number>7</number>], Seite <pages>981</pages>-<pages>988</pages>. </citation>
[202] <citation id="_bib202" published="yes" workType="Journal"><workauthor>Murray, G. I.; Duncan, M. E.; O'Neil, P.; Melvin, W. T. und Fothergill, J. E.</workauthor> (<pubdate>1996</pubdate>): <articletitle>Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer</articletitle>, <worktitle>Nat.Med</worktitle> <volume>2</volume> [<number>4</number>], Seite <pages>461</pages>-<pages>462</pages>. </citation>
[203] <citation id="_bib203" published="yes" workType="Journal"><workauthor>Davidson, B.; Goldberg, I.; Kopolovic, J.; Lerner-Geva, L.; Gotlieb, W. H.; Weis, B.; Ben Baruch, G. und Reich, R.</workauthor> (<pubdate>1999</pubdate>): <articletitle>Expression of matrix metalloproteinase-9 in squamous cell carcinoma of the uterine cervix-clinicopathologic study using immunohistochemistry and mRNA in situ hybridization</articletitle>, <worktitle>Gynecol.Oncol.</worktitle> <volume>72</volume> [<number>3</number>], Seite <pages>380</pages>-<pages>386</pages>. </citation>
[204] <citation id="_bib204" published="yes" workType="Journal"><workauthor>Sheu, B. C.; Hsu, S. M.; Ho, H. N.; Lien, H. C.; Huang, S. C. und Lin, R. H.</workauthor> (<pubdate>2001</pubdate>): <articletitle>A novel role of metalloproteinase in cancer-mediated immunosuppression</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>61</volume> [<number>1</number>], Seite <pages>237</pages>-<pages>242</pages>. </citation>
[205] <citation id="_bib205" published="yes" workType="Journal"><workauthor>Sheu, B. C.; Lien, H. C.; Ho, H. N.; Lin, H. H.; Chow, S. N.; Huang, S. C. und Hsu, S. M.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Increased expression and activation of gelatinolytic matrix metalloproteinases is associated with the progression and recurrence of human cervical cancer</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>63</volume> [<number>19</number>], Seite <pages>6537</pages>-<pages>6542</pages>. </citation>
[206] <citation id="_bib206" published="yes" workType="Journal"><workauthor>Martignetti, J. A.; Aqeel, A. A.; Sewairi, W. A.; Boumah, C. E.; Kambouris, M.; Mayouf, S. A.; Sheth, K. V.; Eid, W. A.; Dowling, O.; Harris, J.; Glucksman, M. J.; Bahabri, S.; Meyer, B. F. und Desnick, R. J.</workauthor> (<pubdate>2001</pubdate>): <articletitle>Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome</articletitle>, <worktitle>Nat.Genet.</worktitle> <volume>28</volume> [<number>3</number>], Seite <pages>261</pages>-<pages>265</pages>. </citation>
[207] <citation id="_bib207" published="yes" workType="Journal"><workauthor>Trudel, D.; Fradet, Y.; Meyer, F.; Harel, F. und Tetu, B.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Significance of MMP-2 expression in prostate cancer: an immunohistochemical study</articletitle>, <worktitle>Cancer Res.</worktitle> <volume>63</volume> [<number>23</number>], Seite <pages>8511</pages>-<pages>8515</pages>. </citation>
[208] <citation id="_bib208" published="yes" workType="Journal"><workauthor>Lichtinghagen, R.; Musholt, P. B.; Stephan, C.; Lein, M.; Kristiansen, G.; Hauptmann, S.; Rudolph, B.; Schnorr, D.; Loening, S. A. und Jung, K.</workauthor> (<pubdate>2003</pubdate>): <articletitle>mRNA expression profile of matrix metalloproteinases and their tissue inhibitors in malignant and non-malignant prostatic tissue</articletitle>, <worktitle>Anticancer Res.</worktitle> <volume>23</volume> [<number>3B</number>], Seite <pages>2617</pages>-<pages>2624</pages>. </citation>
[209] <citation id="_bib209" published="yes" workType="Journal"><workauthor>Jung, K.; Krell, H. W.; Ortel, B.; Hasan, T.; Romer, A.; Schnorr, D.; Loening, S. A. und Lein, M.</workauthor> (<pubdate>2003</pubdate>): <articletitle>Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats</articletitle>, <worktitle>Prostate</worktitle> <volume>54</volume> [<number>3</number>], Seite <pages>206</pages>-<pages>211</pages>. </citation>

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