[Seite 95↓]


Annacker O, Burlen-Defranoux O, Pimenta-Araujo R, Cumano A, Bandeira A. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment. J Immunol. 2000 Apr 1; 164(7): 3573-80.

Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Barbosa TC, Cumano A, Bandeira A. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol. 2001 Mar 1; 166(5): 3008-18.

Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med. 1999 Oct 4; 190(7): 995-1004.

Auchincloss H Jr, Sultan H. Antigen processing and presentation in transplantation. Curr Opin Immunol. 1996 Oct; 8(5): 681-7.

Bacchetta R, Bigler M, Touraine JL, Parkman R, Tovo PA, Abrams J, de Waal Malefyt R, de Vries JE, Roncarolo MG. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med. 1994 Feb 1; 179(2): 493-502.

Badrichani AZ, Ferran C. A20 and BCL proteins exert a broad and complementary cytoprotective effect in endothelial cells via blockade of NF-kappaB and NFAT. Transplant Proc. 2001 Feb-Mar; 33(1-2): 450.

Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 1; 167(3): 1245-53.

Bejarano MT, de Waal Malefyt R, Abrams JS, Bigler M, Bacchetta R, de Vries JE, Roncarolo MG. Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures. Int Immunol. 1992 Dec; 4(12): 1389-97.

Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC. A role for CD95 ligand in preventing graft rejection. Nature. 1995 Oct 19; 377(6550): 630-2.

Benichou G. Direct and indirect antigen recognition: the pathways to allograft immune rejection. Front Biosci. 1999 May 15; 4:D476-80.

Beverly B, Kang SM, Lenardo MJ, Schwartz RH. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol. 1992 Jun; 4(6): 661-71.

Blaese RM, Culver KW, Miller D, Carter C, Fleisher T, Clerici M, Shearer G, Chang L, Chiang Y, Tolsthev P, Grennblatt JJ, Rosenberg SA, Klein H, Berger M, Mullen CA, Ramsey WJ, Muul L, Morgan RA, Anderson WF. T-Lymphocyte-Directed Gene Therapie for ADA- SCID: Initial Trial Results After 4 Years. Science 1995; 270: 475-477.

Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Narula SK, Smith SR, Roncarolo MG, Vallera DA. Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease. Transplantation. 1998 Nov 15; 66(9): 1220-9.

Bollard CM, Heslop HE, Brenner MK. Gene-marking studies of hematopoietic cells. Int J Hematol. 2001 Jan; 73(1): 14-22.

[Seite 96↓]

Briscoe DM, Alexander SI, Lichtman AH. Interactions between T lymphocytes and endothelial cells in allograft rejection. Curr Opin Immunol. 1998 Oct; 10(5): 525-31.

Burns J.C., Friedmann T., Driever W., Burrascano M., and Yee J.K. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl. Acad. Sci. 1993 90: 8033 – 8037.

Campos L, Deli BC, Kern JH, Kim JI, Naji A, Barker CF, Markmann JF. Survival of MHC deficient mouse heterotopic cardiac allografts and xenografts. Transplant Proc. 1995 Feb; 27(1): 254-5.

Chan SY, Goodman RE, Szmuszkovicz JR, Roessler B, Eichwald EJ, Bishop DK. DNA-liposome versus adenoviral mediated gene transfer of transforming growth factor beta1 in vascularized cardiac allografts: differential sensitivity of CD4+ and CD8+ T cells to transforming growth factor beta1. Transplantation. 2000 Nov 15; 70(9): 1292-301.

Ciancio G, Burke GW, Miller J. Current treatment practice in immunosuppression. Expert Opin Pharmacother. 2000 Dec; 1(7): 1307-30.

Cjte I, Rogers NJ, Lechler RI. Allorecognition. Transfus Clin Biol. 2001 Jun; 8(3): 318-23.

Cobbold S, Waldmann H. Infectious tolerance. Curr Opin Immunol. 1998 Oct; 10(5): 518-24.

Coito AJ, Kupiec-Weglinski JW. Extracellular matrix proteins: bystanders or active participants in the allograft rejection cascade? Ann Transplant. 1996; 1(3): 14-8.

Contreras JL, Bilbao G, Smyth CA, Jiang XL, Eckhoff DE, Jenkins SM, Thomas FT, Curiel DT, Thomas JM. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation. 2001 Apr 27; 71(8): 1015-23.

Croft M. Activation of naive, memory and effector T cells. Curr Opin Immunol. 1994 Jun; 6(3): 431-7.

David A, Chetritt J, Guillot C, Tesson L, Heslan JM, Cuturi MC, Soulillou JP, Anegon I. Interleukin-10 produced by recombinant adenovirus prolongs survival of cardiac allografts in rats. Gene Ther. 2000 Mar; 7(6): 505-10.

de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991a Nov 1; 174(5): 1209-20.

de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 1991b Oct 1; 174(4): 915-24.

DeBruyne LA, Li K, Chan SY, Qin L, Bishop DK, Bromberg JS. Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses. Gene Ther 1998 Aug; 5(8): 1079-87

[Seite 97↓]

Ding Y, Qin L, Zamarin D, Kotenko SV, Pestka S, Moore KW, Bromberg JS. Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation. J Immunol. 2001 Dec 15; 167(12): 6884-92.

Dunn CJ, Wagstaff AJ, Perry CM, Plosker GL, Goa KL. Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation. Drugs. 2001; 61(13): 1957-2016.

Emery DW, Sablinski T, Shimada H, Germana S, Gianello P, Foley A, Shulman S, Arn S, Fishman J, Lorf T, Nickeleit V, Colvin RB, Sachs DH, LeGuern C. Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity. Transplantation. 1997 Nov 27; 64(10): 1414-23.

Finkelman FD, Morris SC, Orekhova T, Mori M, Donaldson D, Reiner SL, Reilly NL, Schopf L, Urban JF Jr. Stat6 regulation of in vivo IL-4 responses. J Immunol. 2000 Mar 1; 164(5): 2303-10.

Flugel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, Ellwart JW, Willem M, Lassmann H, Wekerle H. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity. 2001 May; 14(5): 547-60.

Flugel A, Willem M, Berkowicz T, Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat Med. 1999 Jul; 5(7): 843-7.

Frauwirth KA, Thompson CB. Activation and inhibition of lymphocytes by costimulation. J Clin Invest. 2002 Feb; 109(3): 295-9.

Gajewski TF, Goldwasser E, Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. II. inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor. IFN-gamma J Immunol. 1988 Oct 15; 141(8): 2635-42.

Geissler EK, Graeb C, Tange S, Guba M, Jauch KW, Scherer MN. Effective use of donor MHC class I gene therapy in organ transplantation: prevention of antibody-mediated hyperacute heart allograft rejection in highly sensitized rat recipients. Hum Gene Ther. 2000 Feb 10; 11(3): 459-69.

Goudy K, Song S, Wasserfall C, Zhang YC, Kapturczak M, Muir A, Powers M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Ellis TM, Flotte TR, Atkinson MA. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24): 13913-8.

Gould DS, Auchincloss H Jr. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol Today. 1999 Feb; 20(2): 77-82.

Graca L, Thompson S, Lin CY, Adams E, Cobbold SP, Waldmann H. Both CD4(+)CD25(+) and CD4(+)CD25(-) Regulatory Cells Mediate Dominant Transplantation Tolerance. J Immunol 2002 Jun 1; 168(11): 5558-65

[Seite 98↓]

Greil R, Egle A, Villunger A. On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model. Leuk Lymphoma. 1998 Nov; 31(5-6): 477-90.

Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med. 1996 Jul 1; 184(1): 19-29.

Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997 Oct 16; 389(6652): 737-42.

Guillot C, Guillonneau C, Mathieu P, Gerdes CA, Menoret S, Braudeau C, Tesson L, Renaudin K, Castro MG, Lowenstein PR, Anegon I. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. J Immunol. 2002 Feb 15; 168(4): 1600-9.

Hammer MH, Flugel A, Seifert M, Lehmann M, Brandt C, Volk HD, Ritter T. Potential of allospecific gene-engineered T cells in transplantation gene therapy: specific T cell activation determines transgene expression in vitro and in vivo. Hum Gene Ther. 2000 Jun 10; 11(9): 1303-11.

Hammer MH, Schroder G, Risch K, Flugel A, Volk HD, Lehmann M, Ritter T. Antigen-dependent transgene expression in kidney transplantation: a novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol. 2002 Feb; 13(2): 511-8.

Hammer MH, Zhai Y, Katori M, Ritter T, Volk HD, Coito AJ, Kupiec-Weglinski JW. Homing of in vitro-generated donor antigen-reactive CD4+ T lymphocytes to renal allografts is alpha 4 beta 1 but not alpha L beta 2 integrin dependent. J Immunol. 2001 Jan 1; 166(1): 596-601.

Haviernik P, Festin SM, Opavsky R, Koller RP, Barr NI, Neil JC, Wolff L. Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia. J Gen Virol. 2002 Apr; 83(Pt 4): 819-27.

Heidecke CD, Hancock WW, Westerholt S, Sewczik T, Jakobs F, Zantl N, Varzaru A, Siegling A, Kurrle R, Deusch K, Volk HD, Kupiec-Weglinski JW. alpha/beta-T cell receptor-directed therapy in rat allograft recipients. Long-term survival of cardiac allografts after pretreatment with R73 mAb is associated with upregulation of Th2-type cytokines. Transplantation. 1996 Mar 27; 61(6): 948-56.

Henke PK, DeBrunye LA, Strieter RM, Bromberg JS, Prince M, Kadell AM, Sarkar M, Londy F, Wakefield TW. Viral IL-10 gene transfer decreases inflammation and cell adhesion molecule expression in a rat model of venous thrombosis. J Immunol. 2000 Feb 15; 164(4): 2131-41.

Hernandez-Fuentes MP, Baker RJ, Lechler RI. The alloresponse. Rev Immunogenet. 1999; 1(3): 282-96.

Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999 Jan 21; 397(6716): 263-6.

[Seite 99↓]

Ito S, Camussi G, Tetta C, Milgrom F, Andres G. Hyperacute renal allograft rejection in the rabbit. The role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leukocytes and from platelets. Lab Invest. 1984 Aug; 51(2): 148-61.

Janeway AC, Travers P. Immunologie. 1995 Spektrum Akademischer Verlag GmbH, Heidelberg, S.163-170,

Jonuleit H, Schmitt E, Steinbrink K, Enk AH. Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 2001 Jul; 22(7): 394-400.

Josien R, Heslan M, Brouard S, Soulillou JP, Cuturi MC. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood. 1998 Dec 15; 92(12): 4539-44.

Kato H, Ritter T, Ke B, Murakami M, Kusano M, Busuttil RW, Kupiec-Weglinski JW. Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway. Transplant Proc. 2000 Mar; 32(2): 245-6.

Kawamoto S, Nitta Y, Tashiro F, Nakano A, Yamato E, Tahara H, Tabayashi K, Miyazaki J. Suppression of T(h)1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10. Int Immunol. 2001 May; 13(5): 685-94.

Ke B, Coito AJ, Kato H, Zhai Y, Wang T, Sawitzki B, Seu P, Busuttil RW, Kupiec-Weglinski JW. Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation. 2000 Apr 27; 69(8): 1690-4.

Ke B, Ritter T, Kato H, Zhai Y, Li J, Lehmann M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol. 2000 Jun 1; 164(11): 5739-45.

Khayyamian S, Hutloff A, Buchner K, Grafe M, Henn V, Kroczek RA, Mages HW. ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9): 6198-203.

Kindred B. Rejection of skin grafts from different inbred strains by nude mice reconstituted with allogeneic or congenic thymus cell suspensions. Eur J Immunol. 1974 May; 4(5): 388-9.

Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol. 2002 Feb 1; 168(3): 1080-6.

Kirbey JA,. Funktion of Leukocyte Adhesion Molecules During Allograft Rejektion, in transplantation Biology, N.L Tilney, T.B. Strom, and L.C. Paul, Editors. 1996, Lippincott-Raven: New York. P. 137-150.

Kirk AD, Burkly LC, Batty DS, Baumgartner RE, Berning JD, Buchanan K, Fechner JH Jr, Germond RL, Kampen RL, Patterson NB, Swanson SJ, Tadaki DK, TenHoor CN, White L, Knechtle SJ, Harlan DM. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med. 1999 Jun; 5(6): 686-93.

[Seite 100↓]

Kirk CJ, Mule JJ. Gene-modified dendritic cells for use in tumor vaccines. Hum Gene Ther. 2000 Apr 10; 11(6): 797-806.

Knechtle SJ, Kirk AD, Fechner JH Jr, Hong X, Dong Y, Hamawy MM, Harlan DM. Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand. Transplant Proc. 1999 May; 31(3B Suppl): 27S-28S.

Lalor PF, Adams DH. Lymphocyte homing to allografts. Transplantation. 2000 Oct 27; 70(8): 1131-9.

Lanzavecchia A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell. 2001 Aug 10; 106(3): 263-6.

Laskowski IA, Pratschke J, Wilhelm MJ, Dong VM, Beato F, Taal M, Gasser M, Hancock WW, Sayegh MH, Tilney NL. Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol. 2002 Feb; 13(2): 519-27.

Lehmann M, Graser E, Risch K, Hancock WW, Muller A, Kuttler B, Hahn HJ, Kupiec-Weglinski JW, Brock J, Volk HD. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation. 1997 Oct 27; 64(8): 1181-7.

Lehmann M, Sternkopf F, Metz F, Brock J, Docke WD, Plantikow A, Kuttler B, Hahn HJ, Ringel B, Volk HD. Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody. Transplantation. 1992 Dec; 54(6): 959-62.

Levy, J.A.. The Retroviridae, 1,2. 1992 Plenum Press, New York and London.

Li W, Fu F, Lu L, Narula SK, Fung JJ, Thomson AW, Qian S. Recipient pretreatment with mammalian IL-10 prolongs mouse cardiac allograft survival by inhibition of anti-donor T cell responses. Transplant Proc. 1999 Feb-Mar; 31(1-2): 115.

Li W, Lu L, Li Y, Fu F, Fung JJ, Thomson AW, Qian S. High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation. Transplant Proc. 1997 Feb-Mar; 29(1-2): 1081-2.

Liew FY. T(H)1 and T(H)2 cells: a historical perspective. Nature Rev Immunol. 2002 Jan; 2(1): 55-60.

Lowry RP. DTH-Induced Injury, in Transplantation Biology, N.L.Tilney, T.B. Strom, and L.C. Paul, Editors. 1996, Lippincott-Raven: New York. P. 487-502.

Lu L, Gambotto A, Lee WC, Qian S, Bonham CA, Robbins PD, Thomson AW. Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients. Gene Ther. 1999 Apr; 6(4): 554-63.

Medawar PB. Memoir of a thinking radish. 1986 Oxford University Press, Oxford,

Merville P, Pouteil-Noble C, Wijdenes J, Potaux L, Touraine JL, Banchereau J. Detection of single cells secreting IFN-gamma, IL-6, and IL-10 in irreversibly rejected human kidney allografts, and their modulation by IL-2 and IL-4. Transplantation. 1993 Mar; 55(3): 639-46.

[Seite 101↓]

Miller JF, Kurts C, Allison J, Kosaka H, Carbone F, Heath WR. Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigens. Immunol Rev. 1998 Oct; 165: 267-77.

Miller, A.D., Garcia, J.,V; von Suhr, N., Lynch, C.M., Wilson, C., and Eiden, M.V. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J. Virol. 1991 65: 2220 - 2224.

Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001; 19: 683-765.

Mosmann TR, Coffman RL. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol. 1989; 46: 111-47.

Muller A, Schmitt L, Raftery M, Schonrich G. Paralysis of B7 co-stimulation through the effect of viral IL-10 on T cells as a mechanism of local tolerance induction. Eur J Immunol. 1998 Nov; 28(11): 3488-98.

Najafian N, Sayegh MH. CTLA4-Ig: a novel immunosuppressive agent. Expert Opin Investig Drugs. 2000 Sep; 9(9): 2147-57.

Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001 Sep 3; 194(5): 629-44.

Naldini L. Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr Opin Biotechnol. 1998 Oct; 9(5): 457-63. Review.

Naviaux RK, Verma IM. Retroviral vectors for persistent expression in vivo. Curr Opin Biotechnol. 1992 Oct; 3(5): 540-7.

Neefjes JJ, Momburg F, Hammerling GJ. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science. 1993 Aug 6; 261(5122): 769-71.

Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther. 2001 May 20; 12(8): 861-70. Review.

Ode-Hakim S, Docke WD, Kern F, Emmrich F, Volk HD, Reinke P. Delayed-type hypersensitivity-like mechanisms dominate late acute rejection episodes in renal allograft recipients. Transplantation. 1996 Apr 27; 61(8): 1233-40.

Oluwole SF, Chowdhury NC, Jin MX, Hardy MA. Acquired systemic tolerance to islet allografts induced by intrathymic inoculation of alloantigens--a brief review. Ann Transplant. 1997; 2(3): 81-5.

Ono K, Lindsey ES, Creech O Jr. Transplanted rat heart: local graft irradiation. Transplantation. 1969 Mar; 7(3): 176-82.

Onodera K, Chandraker A, Volk HD, Lehmann M, Korom S, Stadlbauer TH, Kato K, Kasai S, Sayegh MH, Kupiec-Weglinski JW. Role of regulatory T cells in the "infectious" tolerance pathway in transplant recipients. Transplant Proc. 1998 Feb; 30(1): 13-5.

[Seite 102↓]

Onodera K, Lehmann M, Akalin E, Volk HD, Sayegh MH, Kupiec-Weglinski JW. Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol. 1996 Sep 1; 157(5): 1944-50.

Onodera K, Volk HD, Ritter T, Kupiec-Weglinski JW. Thymus requirement and antigen dependency in the "infectious" tolerance pathway in transplant recipients. J Immunol. 1998 Jun15; 160(12): 5765-72.

Orosz CG, Pelletier RP. Chronic remodeling pathology in grafts. Curr Opin Immunol. 1997 Oct; 9(5): 676-80.

Ouyang W, Lohning M, Gao Z, Assenmacher M, Ranganath S, Radbruch A, Murphy KM. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity. 2000 Jan; 12(1): 27-37.

Pathan AA, Wilkinson KA, Wilkinson RJ, Latif M, McShane H, Pasvol G, Hill AV, Lalvani A. High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease. Eur J Immunol. 2000 Sep; 30(9): 2713-21.

Penn I. Post-transplant malignancy: the role of immunosuppression. Drug Saf. 2000 Aug; 23(2): 101-13.

Pennycuik PR. Unresponsiveness of nude mice to skin allografts. Transplantation. 1971 Apr; 11(4): 417-8.

Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 1997 Apr; 6(4): 411-7.

Piccirillo CA, Shevach EM. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol. 2001 Aug 1; 167(3): 1137-40.

Pleyer U, Bertelmann E, Rieck P, Hartmann C, Volk HD, Ritter T. Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4. Graefes Arch Clin Exp Ophthalmol. 2000 Jun; 238(6): 531-6.

Pober JS, Orosz CG, Rose ML, Savage CO. Can graft endothelial cells initiate a host anti-graft immune response? Transplantation. 1996 Feb 15; 61(3): 343-9.

Qian S, Li W, Li Y, Fu F, Lu L, Fung JJ, Thomson AW. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation. 1996 Dec 27; 62(12): 1709-14.

Qin L, Chavin KD, Ding Y, Favaro JP, Woodward JE, Lin J, Tahara H, Robbins P, Shaked A, Ho DY, et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10. Transplantation. 1995 Mar 27; 59(6): 809-16.

Qin L, Chavin KD, Ding Y, Tahara H, Favaro JP, Woodward JE, Suzuki T, Robbins PD, Lotze MT, Bromberg JS. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol. 1996 Mar 15; 156(6): 2316-23.

[Seite 103↓]

Qin L, Ding Y, Pahud DR, Robson ND, Shaked A, Bromberg JS. Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum Gene Ther. 1997 Jul 20; 8(11): 1365-74.

Qin L, Ding Y, Tahara H, Bromberg JS. Viral IL-10-induced immunosuppression requires Th2 cytokines and impairs APC function within the allograft. J Immunol. 2001 Feb 15; 166(4): 2385-93.

Qin S, Cobbold SP, Pope H, Elliott J, Kioussis D, Davies J, Waldmann H. "Infectious" transplantation tolerance. Science. 1993 Feb 12; 259(5097): 974-7.

Quinn ER, Lum LG, Trevor KT. T cell activation modulates retrovirus-mediated gene expression. Hum Gene Ther. 1998 Jul 1; 9(10): 1457-67.

Reinke P, Prosch S, Kern F, Volk HD. Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant patients. Transpl Infect Dis. 1999 Sep; 1(3): 157-64.

Ritter T, Lehmann M, Volk H. Improvements in gene therapy: averting the immune response to adenoviral vectors. BioDrugs. 2002; 16(1): 3-10.

Ritter T, Risch K, Schroder G, Kolls J, Siegling A, Graser E, Reinke P, Brock J, Lehmann M, Volk HD. Intragraft overexpression of interleukin-4 is neither sufficient nor essential for tolerance induction to cardiac allografts in a high-responder strain combination. Transplantation. 1999 Nov 15; 68(9): 1427-31.

Ritter T, Vogt K, Rieck P, Schilling-Schon A, Kolls J, Hartmann C, Volk HD, Pleyer U. Adenovirus-mediated gene transfer of interleukin-4 to corneal endothelial cells and organ cultured corneas leads to high IL-4 expression. Exp Eye Res. 1999 Nov; 69(5): 563-8.

Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease. Int J Clin Lab Res. 1991; 21(2): 152-8.

Roncarolo MG, Levings MK, Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J Exp Med. 2001 Jan 15; 193(2): F5-9.

Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol. 2000 Dec; 12(6): 676-83.

Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol. 2002; 20: 323-70.

Russell, S.R., Hawkins, R.E., and Winter, G. Retroviral vectors displaying functional antibody fragments. Nucleic Acids Res. 1993 21: 1081 – 1085.

Sachs DH, Bodine DM, Moulton AD, Pearson DA, Nienhuis AW, Sykes M. Tolerance induction using autologous bone marrow modified with an allogeneic class I MHC gene. Transplant Proc. 1993 Feb; 25(1 Pt 1): 348-9.

Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning. Band 1. 1989 Cold Spring Harbor Laboratory Press, Second Edition New York, S.1.82-1.84,

[Seite 104↓]

Sawitzki B, Lehmann M, Ritter T, Graser E, Kupiec-Weglinski JW, Volk HD. Regulatory tolerance-mediating T cells in transplantation tolerance. Transplant Proc. 2001 May; 33(3): 2092-3.

Sawitzki B, Lehmann M, Vogt K, Risch K, Brock J, Kupiec-Weglinski JW, Volk HD. Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis. Eur J Immunol. 2002 Mar; 32(3): 800-9.

Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Linsley PS, Turka LA. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med. 1995 May 1; 181(5): 1869-74.

Sayegh MH, Carpenter CB. Role of indirect allorecognition in allograft rejection. Int Rev Immunol. 1996; 13(3): 221-9.

Sekine Y, Bowen LK, Heidler KM, Van Rooijen N, Brown JW, Cummings OW, Wilkes DS. Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation. J Immunol. 1997 Oct 15; 159(8): 4084-93.

Shannon MF, Himes SR, Coles LS. GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells. J Leukoc Biol. 1995 May; 57(5): 767-73.

Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nature Rev Immunol. 2002 Feb; 2(2): 116-26.

Shevach EM, McHugh RS, Piccirillo CA, Thornton AM. Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev. 2001 Aug; 182: 58-67.

Shimomura K, Hardy MA, Oluwole SF. Tolerance induction to cardiac allografts by simultaneous or sequential intrathymic inoculation of disparate alloantigens. Transplantation. 1995 Oct 27; 60(8): 806-11.

Shinozaki K, Yahata H, Tanji H, Sakaguchi T, Ito H, Dohi K. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation. Gene Ther 1999 May; 6(5): 816-22

Siegling A, Lehmann M, Riedel H, Platzer C, Brock J, Emmrich F, Volk HD. A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts. Transplantation. 1994 Feb; 57(3): 464-7.

Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF. Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice. Transplantation. 1997 Oct 15; 64(7): 1040-9.

Steinbrink K, Graulich E, Kubsch S, Knop J, Enk AH. CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood. 2002 Apr 1; 99(7): 2468-76.

[Seite 105↓]

Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH. Induction of tolerance by IL-10-treated dendritic cells. J Immunol. 1997 Nov 15; 159(10): 4772-80.

Stephens LA, Mason D. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J Immunol. 2000 Sep 15; 165(6): 3105-10.

Suzuki T, Tahara H, Narula S, Moore KW, Robbins PD, Lotze MT. Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med. 1995 Aug 1; 182(2): 477-86.

Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol. 1990 Dec 1; 145(11): 3796-806.

Takayama T, Morelli AE, Onai N, Hirao M, Matsushima K, Tahara H, Thomson AW. Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J Immunol. 2001 Jun 15; 166(12): 7136-43.

Takayama T, Morelli AE, Robbins PD, Tahara H, Thomson AW. Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro. Gene Ther. 2000 Aug; 7(15): 1265-73.

Takayama T, Tahara H, Thomson AW. Transduction of dendritic cell progenitors with a retroviral vector encoding viral interleukin-10 and enhanced green fluorescent protein allows purification of potentially tolerogenic antigen-presenting cells. Transplantation. 1999 Dec 27; 68(12): 1903-9.

Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems. The differential activation of Th2-like effector cells in peripheral tolerance. Transplantation. 1992 Jun; 53(6): 1281-94.

Tashiro H, Shinozaki K, Yahata H, Hayamizu K, Okimoto T, Tanji H, Fudaba Y, Yamamoto H, Fan X, Ito H, Asahara T. Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 hours before donation. Transplantation. 2000 Jul 27; 70(2): 336-9.

Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002 May 15; 99(10): 3493-9.

Tejani A, Emmett L. Acute and chronic rejection. Semin Nephrol. 2001 Sep; 21(5): 498-507.

Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol. 2000 Jan 1; 164(1): 183-90.

Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 1998 Apr 10; 280(5361): 243-8.

Vasilakos JP, Michael JG. Herpes simplex virus class I-restricted peptide induces cytotoxic T lymphocytes in vivo independent of CD4+ T cells. J Immunol. 1993 Mar 15; 150(6): 2346-55.

[Seite 106↓]

Waldmann TA. The IL-2/IL-2 receptor system: a target for rational immune intervention. Trends Pharmacol Sci. 1993 May; 14(5): 159-64.

Walther W, Stein U. Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs. 2000 Aug; 60(2): 249-71.

Weis M, von Scheidt W. Cardiac allograft vasculopathy: a review. Circulation. 1997 Sep 16; 96(6): 2069-77.

Williams A, Peh CA, Elliott T. The cell biology of MHC class I antigen presentation. Tissue Antigens. 2002 Jan; 59(1): 3-17.

Witzke O, Spriewald BM, Ensminger SM, Wood KJ. T cell Targets for Tolerance Induction to Alloantigens: Strategies and Mechanisms. Transplantationsmedizin, 1998. 10: p. 168-179.

Wood KJ, Prior TG. Gene therapy in transplantation. Curr Opin Mol Ther. 2001 Aug; 3(4): 390-8.

Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H Jr, Sayegh MH. CD28-independent costimulation of T cells in alloimmune responses. J Immunol. 2001 Jul 1; 167(1): 140-6.

Yang Z, Chen M, Wu R, Fialkow LB, Bromberg JS, McDuffie M, Naji A, Nadler JL. Suppression of autoimmune diabetes by viral IL-10 gene transfer. J Immunol. 2002 Jun 15; 168(12): 6479-85.

Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, Hammerschmidt W. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood. 1997 Sep 15; 90(6): 2390-7.

Zuo Z, Wang C, Carpenter D, Okada Y, Nicolaidou E, Toyoda M, Trento A, Jordan SC. Prolongation of allograft survival with viral IL-10 transfection in a highly histoincompatible model of rat heart allograft rejection. Transplantation. 2001 Mar 15; 71(5): 686-91.

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