First of all, I would like to thank Prof. Dr. Rainer Borriss for giving me the opportunity to study in his group and also for his guidance, discussion and knowledge that he has shared throughout my study.

DAAD and DIKTI which had given me the financial support that made me possible to study in Germany.

I would also like to thank Dr. Joachim Vater for his mass spectrometric analyses as well as correcting my dissertation and Dr. Wilfrid Bleiss for his scanning electron microscopy analyses.

Next, I would like to thank all of the staffs and students in Bacterial Genetics Department at Humboldt University for the support and nice working atmosphere. Christiana Müller and Sybille Striegl for providing that everything is available for daily activity in the lab. Hua for her initial help. Oliwia for translating the german version of my summary. Kinga, Eva and Lilia for togetherness in the lab and outside activities.

Lastly, I would like to thanks my parents (Bpk. Sukardjo and Ibu Rukmijati) for their endless love and care as well as for being very supportive. My family (my wife Fessy, my daughters Alyssa, Cheryl and Naira) for their support, pray and patient. Lyza and family (Mas Ken and Nesha), Tia and Wulan for their kindness and encouragement to finish my study.

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