<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Synthetische LPS-bindende Peptide in vitro Untersuchungen zur Peptid-LPS-LBP-Interaktion</cms:entry><cms:entry type="author">Mirjam R.  Büttner
			</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">I.</cms:entry><cms:entry id="N1007F" part="chapter1" ref="N1007F" type="pagenumber">1</cms:entry><cms:entry id="N10084" part="chapter1" ref="N10084" type="section">1</cms:entry><cms:entry id="N1008C" part="chapter1" ref="N1008C" type="subsection">1.1</cms:entry><cms:entry id="N10095" part="chapter1" ref="N10095" type="subsection">1.2</cms:entry><cms:entry id="N1009C" part="chapter1" ref="N1009C" type="pagenumber">2</cms:entry><cms:entry id="N100A2" part="chapter1" ref="N100A2" type="subsection">1.3</cms:entry><cms:entry id="N100B1" part="chapter1" ref="N100B1" type="subsection">1.4</cms:entry><cms:entry id="N100B5" part="chapter1" ref="N100B5" type="pagenumber">3</cms:entry><cms:entry id="N100BD" part="chapter1" ref="N100BD" type="block">1.4.1</cms:entry><cms:entry id="N100CD" part="chapter1" ref="N100CD" type="pagenumber">4</cms:entry><cms:entry id="N100D6" part="chapter1" ref="N100D6" type="block">1.4.2</cms:entry><cms:entry id="N100E0" part="chapter1" ref="N100E0" type="subsection">1.5</cms:entry><cms:entry id="N100EA" part="chapter1" ref="N100EA" type="pagenumber">5</cms:entry><cms:entry id="N100F7" part="chapter1" ref="N100F7" type="pagenumber">6</cms:entry><cms:entry id="N100FB" part="chapter1" ref="N100FB" type="mm">604#738</cms:entry><cms:entry id="N10108" part="chapter1" ref="N10108" type="section">2</cms:entry><cms:entry id="N1010C" part="chapter1" ref="N1010C" type="pagenumber">7</cms:entry><cms:entry id="N10119" part="chapter1" ref="N10119" type="pagenumber">8</cms:entry><cms:entry id="N10126" part="chapter1" ref="N10126" type="pagenumber">9</cms:entry><cms:entry id="N1012E" part="chapter1" ref="N1012E" type="subsection">2.1</cms:entry><cms:entry id="N1013B" part="chapter1" ref="N1013B" type="pagenumber">10</cms:entry><cms:entry id="N10148" part="chapter1" ref="N10148" type="section">3</cms:entry><cms:entry id="N1014F" part="chapter1" ref="N1014F" type="pagenumber">11</cms:entry><cms:entry id="N10161" part="chapter1" ref="N10161" type="pagenumber">12</cms:entry><cms:entry id="N10165" part="chapter1" ref="N10165" type="mm">623#256</cms:entry><cms:entry id="N10172" part="chapter1" ref="N10172" type="section">4</cms:entry><cms:entry id="N10179" part="chapter1" ref="N10179" type="pagenumber">13</cms:entry><cms:entry id="N1017E" part="chapter1" ref="N1017E" type="subsection">4.1</cms:entry><cms:entry id="N10188" part="chapter1" ref="N10188" type="pagenumber">14</cms:entry><cms:entry id="N1018E" part="chapter1" ref="N1018E" type="subsection">4.2</cms:entry><cms:entry id="N1019B" part="chapter1" ref="N1019B" type="table"/><cms:entry id="N101A2" part="chapter1" ref="N101A2" type="pagenumber">15</cms:entry><cms:entry id="N10271" part="chapter1" ref="N10271" type="subsection">4.3</cms:entry><cms:entry id="N1027B" part="chapter1" ref="N1027B" type="pagenumber">16</cms:entry><cms:entry id="N10281" part="chapter1" ref="N10281" type="subsection">4.4</cms:entry><cms:entry id="N10290" part="chapter1" ref="N10290" type="subsection">4.5</cms:entry><cms:entry id="N10297" part="chapter1" ref="N10297" type="pagenumber">17</cms:entry><cms:entry id="N102A0" part="chapter1" ref="N102A0" type="subsection">4.6</cms:entry><cms:entry id="N102AA" part="chapter1" ref="N102AA" type="section">5</cms:entry><cms:entry id="N102B4" part="chapter1" ref="N102B4" type="pagenumber">18</cms:entry><cms:entry id="N102BB" part="chapter1" ref="N102BB" type="mm">606#389</cms:entry><cms:entry id="N102C4" part="chapter1" ref="N102C4" type="subsection">5.1</cms:entry><cms:entry id="N102CE" part="chapter1" ref="N102CE" type="pagenumber">19</cms:entry><cms:entry id="N102DB" part="chapter1" ref="N102DB" type="mm">615#210</cms:entry><cms:entry id="N102E6" part="chapter1" ref="N102E6" type="section">6</cms:entry><cms:entry id="N102F0" part="chapter1" ref="N102F0" type="pagenumber">20</cms:entry><cms:entry id="N102F9" part="chapter1" ref="N102F9" type="section">7</cms:entry><cms:entry id="N10300" part="chapter1" ref="N10300" type="pagenumber">21</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">II.</cms:entry><cms:entry id="N10311" part="chapter2" ref="N10311" type="pagenumber">22</cms:entry><cms:entry id="N10316" part="chapter2" ref="N10316" type="section">1</cms:entry><cms:entry id="N10323" part="chapter2" ref="N10323" type="pagenumber">23</cms:entry><cms:entry id="N10327" part="chapter2" ref="N10327" type="mm">608#523</cms:entry><cms:entry id="N10337" part="chapter2" ref="N10337" type="table"/><cms:entry id="N1054E" part="chapter2" ref="N1054E" type="section">2</cms:entry><cms:entry id="N10552" part="chapter2" ref="N10552" type="pagenumber">24</cms:entry><cms:entry id="N1055B" part="chapter2" ref="N1055B" type="section">3</cms:entry><cms:entry id="N10564" part="chapter2" ref="N10564" type="section">4</cms:entry><cms:entry id="N10571" part="chapter2" ref="N10571" type="pagenumber">25</cms:entry><cms:entry id="N10592" part="chapter2" ref="N10592" type="section">5</cms:entry><cms:entry id="N10596" part="chapter2" ref="N10596" type="pagenumber">26</cms:entry><cms:entry id="N1059E" part="chapter2" ref="N1059E" type="subsection">5.1</cms:entry><cms:entry id="N105AD" part="chapter2" ref="N105AD" type="subsection">5.2</cms:entry><cms:entry id="N105B6" part="chapter2" ref="N105B6" type="pagenumber">27</cms:entry><cms:entry id="N105BC" part="chapter2" ref="N105BC" type="subsection">5.3</cms:entry><cms:entry id="N105CC" part="chapter2" ref="N105CC" type="section">6</cms:entry><cms:entry id="N105D6" part="chapter2" ref="N105D6" type="pagenumber">28</cms:entry><cms:entry id="N105DC" part="chapter2" ref="N105DC" type="section">7</cms:entry><cms:entry id="N105E4" part="chapter2" ref="N105E4" type="subsection">7.1</cms:entry><cms:entry id="N105ED" part="chapter2" ref="N105ED" type="subsection">7.2</cms:entry><cms:entry id="N105F4" part="chapter2" ref="N105F4" type="pagenumber">29</cms:entry><cms:entry id="N105F9" part="chapter2" ref="N105F9" type="block">7.2.1</cms:entry><cms:entry id="N1061C" part="chapter2" ref="N1061C" type="block">7.2.2</cms:entry><cms:entry id="N10629" part="chapter2" ref="N10629" type="pagenumber">30</cms:entry><cms:entry id="N10639" part="chapter2" ref="N10639" type="section">8</cms:entry><cms:entry id="N1065E" part="chapter2" ref="N1065E" type="subsection">8.1</cms:entry><cms:entry id="N10662" part="chapter2" ref="N10662" type="pagenumber">31</cms:entry><cms:entry id="N10673" part="chapter2" ref="N10673" type="subsection">8.2</cms:entry><cms:entry id="N10684" part="chapter2" ref="N10684" type="pagenumber">32</cms:entry><cms:entry id="N10692" part="chapter2" ref="N10692" type="subsection">8.3</cms:entry><cms:entry id="N1069F" part="chapter2" ref="N1069F" type="pagenumber">33</cms:entry><cms:entry id="N106A6" part="chapter2" ref="N106A6" type="section">9</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">III.</cms:entry><cms:entry id="N106B4" part="chapter3" ref="N106B4" type="pagenumber">34</cms:entry><cms:entry id="N106B9" part="chapter3" ref="N106B9" type="section">1</cms:entry><cms:entry id="N106C6" part="chapter3" ref="N106C6" type="pagenumber">35</cms:entry><cms:entry id="N106CA" part="chapter3" ref="N106CA" type="mm">624#624</cms:entry><cms:entry id="N106D9" part="chapter3" ref="N106D9" type="pagenumber">36</cms:entry><cms:entry id="N106E0" part="chapter3" ref="N106E0" type="mm">624#600</cms:entry><cms:entry id="N106EF" part="chapter3" ref="N106EF" type="pagenumber">37</cms:entry><cms:entry id="N106F5" part="chapter3" ref="N106F5" type="section">2</cms:entry><cms:entry id="N106FF" part="chapter3" ref="N106FF" type="subsection">2.1</cms:entry><cms:entry id="N10708" part="chapter3" ref="N10708" type="pagenumber">38</cms:entry><cms:entry id="N10711" part="chapter3" ref="N10711" type="mm">573#377</cms:entry><cms:entry id="N1071E" part="chapter3" ref="N1071E" type="mm">587#369</cms:entry><cms:entry id="N1072A" part="chapter3" ref="N1072A" type="subsection">2.2</cms:entry><cms:entry id="N10733" part="chapter3" ref="N10733" type="pagenumber">40</cms:entry><cms:entry id="N1073A" part="chapter3" ref="N1073A" type="mm">624#792</cms:entry><cms:entry id="N10746" part="chapter3" ref="N10746" type="subsection">2.3</cms:entry><cms:entry id="N10754" part="chapter3" ref="N10754" type="pagenumber">42</cms:entry><cms:entry id="N1075D" part="chapter3" ref="N1075D" type="mm">624#773</cms:entry><cms:entry id="N1076D" part="chapter3" ref="N1076D" type="section">3</cms:entry><cms:entry id="N1077F" part="chapter3" ref="N1077F" type="pagenumber">44</cms:entry><cms:entry id="N10783" part="chapter3" ref="N10783" type="mm">624#645</cms:entry><cms:entry id="N1078F" part="chapter3" ref="N1078F" type="section">4</cms:entry><cms:entry id="N10796" part="chapter3" ref="N10796" type="pagenumber">45</cms:entry><cms:entry id="N1079C" part="chapter3" ref="N1079C" type="section">5</cms:entry><cms:entry id="N107A4" part="chapter3" ref="N107A4" type="subsection">5.1</cms:entry><cms:entry id="N107AD" part="chapter3" ref="N107AD" type="pagenumber">46</cms:entry><cms:entry id="N107B4" part="chapter3" ref="N107B4" type="mm">567#295</cms:entry><cms:entry id="N107C1" part="chapter3" ref="N107C1" type="subsection">5.2</cms:entry><cms:entry id="N107CF" part="chapter3" ref="N107CF" type="pagenumber">47</cms:entry><cms:entry id="N107D3" part="chapter3" ref="N107D3" type="mm">568#527</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">IV.</cms:entry><cms:entry id="N107E3" part="chapter4" ref="N107E3" type="pagenumber">48</cms:entry><cms:entry id="N107ED" part="chapter4" ref="N107ED" type="mm">623#257</cms:entry><cms:entry id="N107F6" part="chapter4" ref="N107F6" type="section">1</cms:entry><cms:entry id="N107FD" part="chapter4" ref="N107FD" type="pagenumber">49</cms:entry><cms:entry id="N10812" part="chapter4" ref="N10812" type="pagenumber">50</cms:entry><cms:entry id="N10818" part="chapter4" ref="N10818" type="section">2</cms:entry><cms:entry id="N10822" part="chapter4" ref="N10822" type="pagenumber">51</cms:entry><cms:entry id="N1082B" part="chapter4" ref="N1082B" type="section">3</cms:entry><cms:entry id="N10837" part="chapter4" ref="N10837" type="section">4</cms:entry><cms:entry id="N1083E" part="chapter4" ref="N1083E" type="pagenumber">52</cms:entry><cms:entry id="N1084A" part="chapter4" ref="N1084A" type="section">5</cms:entry><cms:entry id="N10853" part="chapter4" ref="N10853" type="pagenumber">53</cms:entry><cms:entry id="N1085D" part="chapter4" ref="N1085D" type="pagenumber">54</cms:entry><cms:entry id="N10861" part="chapter4" ref="N10861" type="mm">606#790</cms:entry><cms:entry id="N1086C" part="chapter4" ref="N1086C" type="pagenumber">55</cms:entry><cms:entry id="N10876" part="chapter4" ref="N10876" type="pagenumber">56</cms:entry><cms:entry id="N1087C" part="chapter4" ref="N1087C" type="section">6</cms:entry><cms:entry id="OLE_LINK1" part="chapter4" ref="OLE_LINK1" type="link"/><cms:entry id="N1088F" part="chapter4" ref="N1088F" type="pagenumber">57</cms:entry><cms:entry id="N1089B" part="chapter4" ref="N1089B" type="section">7</cms:entry><cms:entry id="N108A2" part="chapter4" ref="N108A2" type="pagenumber">58</cms:entry><cms:entry id="N108A9" part="chapter4" ref="N108A9" type="mm">507#550</cms:entry><cms:entry id="N108B4" part="chapter4" ref="N108B4" type="pagenumber">59</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">V.</cms:entry><cms:entry id="N108C8" part="chapter5" ref="N108C8" type="pagenumber">60</cms:entry><cms:entry id="N108D5" part="chapter5" ref="N108D5" type="pagenumber">61</cms:entry><cms:entry ref="N108DC" type="back"/><cms:entry ref="N108DE" type="bibliography">
				Literaturverzeichnis</cms:entry><cms:entry ref="N108E2" type="pagenumber">62</cms:entry><cms:entry ref="N109DA" type="pagenumber">63</cms:entry><cms:entry ref="N10AD5" type="pagenumber">64</cms:entry><cms:entry ref="N10BBF" type="pagenumber">65</cms:entry><cms:entry ref="N10C9B" type="pagenumber">66</cms:entry><cms:entry ref="N10D93" type="pagenumber">67</cms:entry><cms:entry ref="N10E7A" type="pagenumber">68</cms:entry><cms:entry ref="N10F7B" type="pagenumber">69</cms:entry><cms:entry ref="N11037" type="pagenumber">70</cms:entry><cms:entry ref="N11138" type="pagenumber">71</cms:entry><cms:entry ref="N11228" type="pagenumber">72</cms:entry><cms:entry ref="N112E4" type="pagenumber">73</cms:entry><cms:entry ref="N113B4" type="pagenumber">74</cms:entry><cms:entry ref="N1148A" type="pagenumber">75</cms:entry><cms:entry ref="N11574" type="pagenumber">76</cms:entry><cms:entry ref="N1164A" type="pagenumber">77</cms:entry><cms:entry id="N116A7" part="N116A7" ref="N116A7" type="abbreviation">
				
Verzeichnis häufig verwendeter Abkürzungen</cms:entry><cms:entry id="N116AB" part="N116A7" ref="N116AB" type="pagenumber">78</cms:entry><cms:entry id="N116B2" part="N116A7" ref="N116B2" type="table"/><cms:entry id="N11904" part="N11904" ref="N11904" type="acknowledgement">
				
Danksagung</cms:entry><cms:entry id="N11908" part="N11904" ref="N11908" type="pagenumber">79</cms:entry><cms:entry id="N1191D" part="N1191D" ref="N1191D" type="declaration"/><cms:entry id="N11923" part="N1191D" ref="N11923" type="pagenumber">80</cms:entry><cms:entry part="N108DE" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N108DE">
			<head>
				<pagenumber id="N108E2" label="62" numbering="arabic" start="62"/>Literaturverzeichnis</head>
			<citation published="yes" workType="Journal">
				<workauthor>Akira, S.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Mammalian Toll-like receptors.</articletitle>
				<worktitle>Curr Opin Immunol</worktitle>
				<number>15,</number>
				<pages>5-11.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Akira, S., Taga, T., and Kishimoto, T.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Interleukin-6 in biology and medicine.</articletitle>
				<worktitle> Adv Immunol</worktitle>
				<number>54,</number>
				<pages>1-78</pages>.</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Alexander, C., and Rietschel, E. T.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Bacterial lipopolysaccharides and innate immunity.</articletitle>
				<worktitle>J Endotoxin Res</worktitle>
				<number>7,</number>
				<pages>167-202.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Appelmelk, B. J., An, Y. Q., Geerts, M., Thijs, B. G., de Boer, H. A., MacLaren, D. M., de Graaff, J., and Nuijens, J. H.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Lactoferrin is a lipid A-binding </articletitle>
				<worktitle>protein. Infect Immun</worktitle>
				<number>62,</number>
				<pages>2628-32.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., and Schwartz, D. A.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.</articletitle>
				<worktitle>Nat Genet</worktitle>
				<number>25,</number>
				<pages>187-91.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Battafaraono, R. J., Dahlberg, P. S., Ratz, C. A., Johnston, J. W., Gray, B. H., Haseman, J. R., Mayo, K. H., and Dunn, D. L.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>Peptide derivatives of three distinct lipopolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha secretion in vitro.</articletitle>
				<worktitle>Surgery</worktitle>
				<number>118,</number>
				<pages>318-24.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Baumann, H., and Gauldie, J.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>The acute phase response.</articletitle>
				<worktitle>Immunol Today</worktitle>
				<number>15,</number>
				<pages>74-80.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Baumgartner, J. D.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Monoclonal anti-endotoxin antibodies for the treatment of gram-negative bacteremia and septic shock.</articletitle>
				<worktitle>Eur J Clin Microbiol Infect Dis</worktitle>
				<number>9,</number>
				<pages>711-6.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Bazil, V., and Strominger, J. L.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes.</articletitle>
				<worktitle>J Immuno</worktitle>
				<number>147,</number>
				<pages>1567-74.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Beamer, L. J., Carroll, S. F., and Eisenberg, D.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>The BPI/LBP family of proteins: a structural analysis of conserved regions.</articletitle>
				<worktitle>Protein Sci</worktitle>
				<number>7,</number>
				<pages>906-14.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Beamer, L. J., Carroll, S. F., and Eisenberg, D.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Crystal structure of human BPI </articletitle>
				<pagenumber id="N109DA" label="63" numbering="arabic" start="63"/>
				<articletitle>and two bound phospholipids at 2.4 angstrom resolution.</articletitle>
				<worktitle>Science</worktitle>
				<number>276,</number>
				<pages>1861-4.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Belvin, M. P., and Anderson, K. V.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>A conserved signaling pathway: the Drosophila toll-dorsal pathway.</articletitle>
				<worktitle>Annu Rev Cell Dev Biol</worktitle>
				<number>12,</number>
				<pages>393-416.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Berger, D., and Beger, H. G.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Evidence for endotoxin binding capacity of human Gc-globulin and transferrin.</articletitle>
				<worktitle>Clin Chim Acta</worktitle>
				<number>163,</number>
				<pages>289-99.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Bernard, G. R., Vincent, J. L., Laterre, P. F.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Efficacy and safety of recombinant human activated protein C for severe sepsis.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>344,</number>
				<pages>699-709.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Bone, R. C.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>The pathogenesis of sepsis.</articletitle>
				<worktitle>Ann Intern Med</worktitle>
				<number>115,</number>
				<pages>457-69.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M., and Sibbald, W. J.</workauthor>
				<pubdate>(1992)</pubdate>. <articletitle>Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest PHysicians/Society of Critical Care Medicine.</articletitle>
				<worktitle>Chest </worktitle>
				<number>101,</number>
				<pages>1644-55.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Brun-Buisson, C.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>The epidemiology of the systemic inflammatory response.</articletitle>
				<worktitle>Intensive Care Med</worktitle>
				<number>26,</number>
				<pages>64-74.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Chen, C., Brock, R., Luh, F., Chou, P. J., Larrick, J. W., Huang, R. F., and Huang, T. H.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes.</articletitle>
				<worktitle>FEBS Lett</worktitle>
				<number>370,</number>
				<pages>46-52.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., and Gusovsky, F.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>274,</number>
				<pages>10689-92.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Cohen, J., and Glauser, M. P.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Septic shock: treatment.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>338,</number>
				<pages>736-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Dankesreiter, S., Hoess, A., Schneider-Mergener, J., Wagner, H., and Miethke, T.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Synthetic endotoxin-binding peptides block endotoxin-triggered TNF- alpha production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>164,</number>
				<pages>4804-11.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N10AD5" label="64" numbering="arabic" start="64"/>
				<workauthor>Danner, R. L., Elin, R. J., Hosseini, J. M., Wesley, R. A., Reilly, J. M. and Parillo, J. E.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Endotoxin in human septic shock.</articletitle>
				<worktitle>Chest</worktitle>
				<number>99,</number>
				<pages>169-75.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>David, S. A.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Towards a rational development of anti-endotoxin agents: novel approaches to sequestration of bacterial endotoxins with small molecules.</articletitle>
				<worktitle>J Mol Recognit</worktitle>
				<number>14,</number>
				<pages>370-87.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Day, J. R., Albers, J. J., Lofton-Day, C. E., Gilbert, T. L., Ching, A. F., Grant, F. J., O'Hara, P. J., Marcovina, S. M., and Adolphson, J. L.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>269,</number>
				<pages>9388-91.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>de Haas, C. J., van der Tol, M. E., Van Kessel, K. P., Verhoef, J., and Van Strijp, J. A.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>A synthetic lipopolysaccharide-binding peptide based on amino acids 27- 39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human blood.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>161,</number>
				<pages>3607-15.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Dellinger, R. P.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Cardiovascular management of septic shock.</articletitle>
				<worktitle>Crit Care Med</worktitle>
				<number>31, </number>
				<pages>946-52.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>De Visser, P. C., Kriek, N. M., van Hooft, P. A., Van Schepdael, A., Filippov, D. V., van der Marel, G. A., Overkleeft, H. S., van Boom, J. H. and Noort, D.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Solid-phase synthesis of polymyxin B1 and analogues via a safety-catch approach.</articletitle>
				<worktitle>J Pert Res</worktitle>
				<number>61,:6</number>
				<pages>298-306.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Dinarello, C. A.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Proinflammatory cytokines.</articletitle>
				<worktitle>Chest</worktitle>
				<number>118,</number>
				<pages>503-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Dinarello, C. A., and Wolff, S. M.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>The role of interleukin-1 in disease.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>328,</number>
				<pages>106-13.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Doolittle, R. F.</workauthor>
				<pubdate>(1984).</pubdate>
				<articletitle>Fibrinogen and fibrin.</articletitle>
				<worktitle>Annu Rev Biochem</worktitle>
				<number>53,</number>
				<pages>195-229.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Drayna, D., Jarnagin, A. S., McLean, J., Henzel, W., Kohr, W., Fielding, C., and Lawn, R.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Cloning and sequencing of human cholesteryl ester transfer protein cDNA.</articletitle>
				<worktitle>Nature</worktitle>
				<number>327,</number>
				<pages>632-4.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N10BBF" label="65" numbering="arabic" start="65"/>
				<workauthor>Durieux, J. J., Vita, N., Popescu, O., Guette, F., Calzada-Wack, J., Munker, R., Schmidt, R. E., Lupker, J., Ferrara, P., Ziegler-Heitbrock, H. W., and et al.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>The two soluble forms of the lipopolysaccharide receptor, CD14: characterization and release by normal human monocytes.</articletitle>
				<worktitle>Eur J Immunol</worktitle>
				<number>24,</number>
				<pages>2006-12.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Elsbach, P., and Weiss, J.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopoly­saccharide.</articletitle>
				<worktitle>Immunobiology</worktitle>
				<number>187,</number>
				<pages>417-29.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Fearon, D. T., and Locksley, R. M.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>The instructive role of innate immunity in the acquired immune response.</articletitle>
				<worktitle>Science</worktitle>
				<number>272,</number>
				<pages>50-3.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Frey, E. A., Miller, D. S., Jahr, T. G., Sundan, A., Bazil, V., Espevik, T., Finlay, B. B., and Wright, S. D.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>Soluble CD14 participates in the response of cells to lipopoly­saccharide.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>176,</number>
				<pages>1665-71.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Friedman, G., Silva, E., and Vincent, J. L.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Has the mortality of septic shock changed with time.</articletitle>
				<worktitle>Crit Care Med</worktitle>
				<number>26,</number>
				<pages>2078-86.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Gabay, C. and Kushner, I.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>Acute-phase proteins and other systemic responses to inflammation.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>340,</number>
				<pages>448-53.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Gauldie, J., Northemann, W., and Fey, G. H.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>144,</number>
				<pages>3804-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Gazzano-Santoro, H., Parent, J. B., Grinna, L., Horwitz, A., Parsons, T., Theofan, G., Elsbach, P., Weiss, J., and Conlon, P. J.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>High-affinity binding of the bacteri­cidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide.</articletitle>
				<worktitle>Infect Immun</worktitle>
				<number>60,</number>
				<pages>4754-61.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Gegner, J. A., Ulevitch, R. J., and Tobias, P. S.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane. </articletitle>
				<worktitle>CD14 J Biol Chem</worktitle>
				<number>270,</number>
				<pages>5320-5.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Ghosh, S., May, M. J., and Kopp, E. B.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>NF-kappa B and Rel proteins: evolutio­</articletitle>
				<pagenumber id="N10C9B" label="66" numbering="arabic" start="66"/>
				<articletitle>narily conserved mediators of immune responses.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>16,</number>
				<pages>225-60.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Glauser, M. P., Zanetti, G., Baumgartner, J. D., and Cohen, J.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Septic shock: pathogenesis.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>338,</number>
				<pages>732-6.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Gray, P. W., Flaggs, G., Leong, S. R., Gumina, R. J., Weiss, J., Ooi, C. E., and Elsbach, P.</workauthor>
				<pubdate>(1989).</pubdate>
				<articletitle>Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>264,</number>
				<pages>9505-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Guha, M., and Mackman, N.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>LPS induction of gene expression in human mono­cytes.</articletitle>
				<worktitle>Cell Signal</worktitle>
				<number>13,</number>
				<pages>85-94.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Guha, M., O'Connell, M. A., Pawlinski, R., Hollis, A., McGovern, P., Yan, S. F., Stern, D., and Mackman, N.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.</articletitle>
				<worktitle>Blood</worktitle>
				<number>98,</number>
				<pages>1429-39.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hack, C. E., Aarden, L. A., and Thijs, L. G.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Role of cytokines in sepsis.</articletitle>
				<worktitle>Adv Immunol</worktitle>
				<number>66,</number>
				<pages>101-95.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hailman, E., Albers, J. J., Wolfbauer, G., Tu, A. Y., and Wright, S. D.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>Neutra­lization and transfer of lipopolysaccharide by phospholipid transfer protein.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>271,</number>
				<pages>12172-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hailman, E., Lichenstein, H. S., Wurfel, M. M., Miller, D. S., Johnson, D. A., Kelley, M., Busse, L. A., Zukowski, M. M., and Wright, S. D.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>179,</number>
				<pages>269-77.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hamann, L., Stamme, C., Ulmer, A. J. and Schumann, R. R.</workauthor>
				<pubdate>(2002).</pubdate>
				<worktitle>Biochem Biophys Res Commun</worktitle>
				<number>295,</number>
				<pages>553-60.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hancock, R. E.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Peptide antibiotics.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>349,</number>
				<pages>418-22.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hancock, R. E. and Scott, M. G.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>The role of antimicrobial peptides in animal defenses.</articletitle>
				<worktitle>Proc Natl Acad Sci USA</worktitle>
				<number>97,</number>
				<pages>8856-61.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N10D93" label="67" numbering="arabic" start="67"/>
				<workauthor>Harris, H. W., Grunfeld, C., Feingold, K. R., and Rapp, J. H.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.</articletitle>
				<worktitle>J Clin Invest</worktitle>
				<number>86,</number>
				<pages>696-702.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hart, P. H., Jones, C. A. and Finlay, J. J.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>Interleukin-4 suppression of monocyte tumor necrosis-alpha production. Dependence on protein synthesis but not cyclic AMP production.</articletitle>
				<worktitle>Immunology</worktitle>
				<number>76,</number>
				<pages>560-5.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Haziot, A., Chen, S., Ferrero, E., Low, M. G., Silber, R., and Goyert, S. M.</workauthor>
				<pubdate>(1988).</pubdate>
				<articletitle>The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>141,</number>
				<pages>547-52.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Haziot, A., Rong, G. W., Silver, J., and Goyert, S. M.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>151,</number>
				<pages>1500-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Heiman, D. F., Astiz, M. E., Rackow, E. C., Rhein, D., Kim, Y. B., and Weil, M. H.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Monophosphoryl lipid A inhibits neutrophil priming by lipopolysaccharide.</articletitle>
				<worktitle>J Lab Clin Med</worktitle>
				<number>116,</number>
				<pages>237-41.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hewett, J. A., and Roth, R. A.</workauthor>
				<pubdate>(1993</pubdate>
				<articletitle>). Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides.</articletitle>
				<worktitle>Pharmacol Rev</worktitle>
				<number>45,</number>
				<pages>382-411.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hoess, A., Watson, S., Siber, G. R., and Liddington, R.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 A resolution.</articletitle>
				<worktitle>Embo J</worktitle>
				<number>12,</number>
				<pages>3351-6.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Höflich, C. und Volk, H.-D.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Immunmodulation in der Sepsis.</articletitle>
				<worktitle>Chirurg</worktitle>
				<number>73,</number>
				<pages>1100-4.</pages>
			</citation>
			<citation published="yes" workType="Misc">
				<workauthor>Holst, O., and Brade, H.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>Chemical structure of the core region of Lipopoly­saccharides</articletitle>. <worktitle>In Bacterial Endotoxic Lipopolysaccharides, Volume 1, D. C. Morrison and J. L. Ryan, eds (Boca Raton, Ann Arbor, London, Tokyo: CRC Pres).</worktitle>
				<pages>136-70.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Hotchkiss, R. S., and Karl, I. E.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>The pathophysiology and treatment of sepsis.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>348,</number>
				<pages>138-50.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N10E7A" label="68" numbering="arabic" start="68"/>
				<workauthor>Janeway, C. A., Jr.</workauthor>
				<pubdate>(1989).</pubdate>
				<articletitle>Approaching the asymptote? Evolution and revolution in immunology.</articletitle>
				<worktitle>Cold Spring Harb Symp Quant Biol</worktitle>
				<number>54,</number>
				<pages>1-13.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Janeway, C. A., Jr., and Medzhitov, R.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Innate immune recognition.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>20,</number>
				<pages>197-216.</pages>
			</citation>
			<citation published="yes" workType="Misc">
				<workauthor>Janeway, C. A., Travers, P., Walport, M. and Copra, J. D.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>Immunobiology. The immune system in health and disease.</articletitle>
				<worktitle>Current Biology</worktitle>
				<editor>Ltd./Garland Publishing Inc.</editor>
				<address>London.</address>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kalsheker, N. A.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>Alpha 1-antichymotrypsin.</articletitle>
				<worktitle>Int J Biochem Cell Biol</worktitle>
				<number>28,</number>
				<pages>961-4.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Karin, M., and Ben-Neriah, Y.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>18,</number>
				<pages>621-63.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kirschning, C. J., Au-Young, J., Lamping, N., Reuter, D., Pfeil, D., Seilhamer, J. J., and Schumann, R. R.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.</articletitle>
				<worktitle>Genomics</worktitle>
				<number>46,</number>
				<pages>416-25.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kirschning, C. J., Wesche, H., Merrill Ayres, T., and Rothe, M.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>188,</number>
				<pages>2091-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kodama, T., Freeman, M., Rohrer, L., Zabrecky, J., Matsudaira, P., and Krieger, M.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.</articletitle>
				<worktitle>Nature</worktitle>
				<number>343,</number>
				<pages>531-5.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kox, W. J., Volk, T., Kox, S. N. and Volk, H.-D.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Immunmodulatory therapies in Sepsis.</articletitle>
				<worktitle>Intensiv Care Med</worktitle>
				<number>26,</number>
				<pages>124-28.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Krauss, J. H., Seydel, U., Weckesser, J., and Mayer, H.</workauthor>
				<pubdate>(1989).</pubdate>
				<articletitle>Structural analysis of the nontoxic lipid A of Rhodobacter capsulatus 37b4.</articletitle>
				<worktitle>Eur J Biochem</worktitle>
				<number>180,</number>
				<pages>519-26.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Kushner, I.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Regulation of the acute phase response by cytokines</articletitle>
				<worktitle>Perspect. Biol Med</worktitle>
				<number>36.</number>
				<pages>611-22.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N10F7B" label="69" numbering="arabic" start="69"/>
				<workauthor>Kushner, I., and Mackiewicz, A.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Acute phase proteins as disease markers.</articletitle>
				<worktitle>Dis Markers</worktitle>
				<number>5,</number>
				<pages>1-11.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Lamping, N., Hoess, A., Yu, B., Park, T. C., Kirschning, C. J., Pfeil, D., Reuter, D., Wright, S. D., Herrmann, F., and Schumann, R. R.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>Effects of site-directed muta­genesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>157,</number>
				<pages>4648-56.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Larrick, J. W., Morgan, J. G., Palings, I., Hirata, M., and Yen, M. H.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Comple­mentary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein.</articletitle>
				<worktitle>Biochem Biophys Res Commun</worktitle>
				<number>179,</number>
				<pages>170-5.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., and Hoffmann, J. A.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults.</articletitle>
				<worktitle>Cell</worktitle>
				<number>86,</number>
				<pages>973-83.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Lemaitre, B., Reichhart, J. M., and Hoffmann, J. A.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.</articletitle>
				<worktitle>Proc Natl Acad Sci U S A</worktitle>
				<number>94,</number>
				<pages>14614-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Lepper, P. M., Held, T. K., Schneider, E. M., Bolke, E., Gerlach, H., and Trautmann, M.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Clinical implications of antibiotic-induced endotoxin release in septic shock.</articletitle>
				<worktitle>Intensive Care Med</worktitle>
				<number>28,</number>
				<pages>824-33.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Levin, J., Poore, T. E., Young, N. S., Margolis, S., Zauber, N. P., Townes, A. S., and Bell, W. R.</workauthor>
				<pubdate>(1972).</pubdate>
				<articletitle>Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement.</articletitle>
				<worktitle>Ann Intern Med</worktitle>
				<number>76,</number>
				<pages>1-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Levin, M., Quint, P. A., Goldstein, B., Barton, P., Bradley, J. S., Shemie, S. D., Yeh, T., Kim, S. S., Cafaro, D. P., Scannon, P. J. and Giroir, B. P.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Recombinant bacteri­cidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI2 meningococcal sepsis study group.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>356,</number>
				<pages>961-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N11037" label="70" numbering="arabic" start="70"/>
				<workauthor>Liu, M. K., Herrera-Velit, P., Brownsey, R. W., and Reiner, N. E.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>153,</number>
				<pages>2642-52.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Loppnow, H., Stelter, F., Schonbeck, U., Schluter, C., Ernst, M., Schutt, C., and Flad, H. D.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>Endotoxin activates human vascular smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14.</articletitle>
				<worktitle>Infect Immun</worktitle>
				<number>63,</number>
				<pages>1020-6.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Martin, G. S., Mannino, D. M., Eaton, S. and Moss, M.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Epidemiology of sepsis in the United States from 1979 through 2000.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>348,</number>
				<pages>1546-54.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Matot, I., and Sprung, C. L.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Definition of sepsis.</articletitle>
				<worktitle>Intensive Care Med</worktitle>
				<number>27,</number>
				<pages>3-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Matthay, M. A.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Severe sepsis : a new treatment with both anticoagulant and antiinflammatory properties.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>344,</number>
				<pages>759-62.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>McCafferty, D. G., Cudic, P., Frankel, B. A., Barkallah, S., Kruger, R. G. and Li, W.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Chemistry and biology of the ramoplanin family of peptide antibiotics.</articletitle>
				<worktitle>Biopo­ly­mers</worktitle>
				<number>66:4,</number>
				<pages>261-84.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Medzhitov, R., and Janeway, C., Jr.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Innate immune recognition: mechanisms and pathways.</articletitle>
				<worktitle>Immunol Rev</worktitle>
				<number>173,</number>
				<pages>89-97.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Medzhitov, R., and Janeway, C. A., Jr.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>An ancient system of host defense.</articletitle>
				<worktitle>Curr Opin Immunol</worktitle>
				<number>10,</number>
				<pages>12-5.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Medzhitov, R., and Janeway, C. A., Jr. </workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Innate immunity: impact on the adaptive immune response.</articletitle>
				<worktitle>Curr Opin Immunol</worktitle>
				<number>9,</number>
				<pages>4-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Medzhitov, R., and Janeway, C. A., Jr.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Self-defense: the fruit fly style.</articletitle>
				<worktitle>Proc Natl Acad Sci U S A</worktitle>
				<number>95,</number>
				<pages>429-30.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Medzhitov, R., Preston-Hurlburt, P., and Janeway, C. A., Jr.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>A human homo­logue of the Drosophila Toll protein signals activation of adaptive immunity.</articletitle>
				<worktitle>Nature</worktitle>
				<number>388,</number>
				<pages>394-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N11138" label="71" numbering="arabic" start="71"/>
				<workauthor>Moldawer, L. L.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Biology of proinflammatory cytokines and their antagonists.</articletitle>
				<worktitle>Crit Care Med</worktitle>
				<number>22,</number>
				<pages>3-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Moore, K. W., O'Garra, A., de Waal Malefyt, R., Vieira, P., and Mosmann, T. R.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Interleukin-10.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>11,</number>
				<pages>165-90.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Morita, T., Ohtsubo, S., Nakamura, T., Tanaka, S., Iwanaga, S., Ohashi, K., and Niwa, M.</workauthor>
				<pubdate>(1985).</pubdate>
				<articletitle>Isolation and biological activities of limulus anticoagulant (anti-LPS factor) which interacts with lipopolysaccharide (LPS).</articletitle>
				<worktitle>J Biochem</worktitle>
				<address>(Tokyo)</address>
				<number>97,</number>
				<pages>1611-20.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Muta, T., Miyata, T., Tokunaga, F., Nakamura, T., and Iwanaga, S.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Primary structure of anti-lipopolysaccharide factor from American horseshoe crab, Limulus polyphemus.</articletitle>
				<worktitle>J Biochem</worktitle>
				<address>(Tokyo)</address>
				<number>101,</number>
				<pages>1321-30.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Nathan, C. F.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Secretory products of macrophages.</articletitle>
				<worktitle>J Clin Invest</worktitle>
				<number>79,</number>
				<pages>319-26.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Nathanson, C., Hoffman, W. D., Suffredini, A. F., Eichacker, P. Q. and Danner, R. L.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Selected treatment strategies for septic shock based on proposed mechanism of pathogenesis.</articletitle>
				<worktitle>Ann Internal Med</worktitle>
				<number>120,</number>
				<pages>771-83.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Netea, M. G., Demacker, P. N., Kullberg, B. J., Jacobs, L. E., Verver-Jansen, T. J., Boerman, O. C., Stalenhoef, A. F., and Van der Meer, J. W.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Bacterial lipopoly­saccharide binds and stimulates cytokine-producing cells before neutralization by endo­genous lipoproteins can occur.</articletitle>
				<worktitle>Cytokine</worktitle>
				<number>10,</number>
				<pages>766-72.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Opal, S. M., Palardy, J. E., Marra, M. N., Fisher, C. J., Jr., McKelligon, B. M., and Scott, R. W.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Relative concentrations of endotoxin-binding proteins in body fluids during infection.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>344,</number>
				<pages>429-31.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Parillo, E. J.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Pathogenetic mechanisms of septic shock.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>328,</number>
				<pages>1471-78.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.</articletitle>
				<worktitle>Science</worktitle>
				<number>282,</number>
				<pages>2085-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N11228" label="72" numbering="arabic" start="72"/>
				<workauthor>Pugin, J., Schurer-Maly, C. C., Leturcq, D., Moriarty, A., Ulevitch, R. J., and Tobias, P. S.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.</articletitle>
				<worktitle>Proc Natl Acad Sci U S A</worktitle>
				<number>90,</number>
				<pages>2744-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Raetz, C. R.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Biochemistry of endotoxins.</articletitle>
				<worktitle>Annu Rev Biochem</worktitle>
				<number>59,</number>
				<pages>129-70.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rangel-Frausto, M. S., Pittet, D., Costigan, M., Hwang, T., Davis, C. S., and Wenzel, R. P.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.</articletitle>
				<worktitle>JAMA</worktitle>
				<number>273,</number>
				<pages>117-23.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Ried, C., Wahl, C., Miethke, T., Wellnhofer, G., Landgraf, C., Schneider-Mergener, J., and Hoess, A.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>High affinity endotoxin-binding and neutralizing peptides based on the crystal structure of recombinant Limulus anti-lipopolysaccharide factor.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>271,</number>
				<pages>28120-7.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rietschel, E. T., Brade, H., Brade, L., Brandenburg, K., Schade, U., Seydel, U., Zahringer, U., Galanos, C., Luderitz, O., Westphal, O.</workauthor>
				<pubdate>(1987).</pubdate>
				<articletitle>Lipid A, the endotoxic center of bacterial lipopolysaccharides: relation of chemical structure to biological activity.</articletitle>
				<worktitle>Prog Clin Biol Res</worktitle>
				<number>231,</number>
				<pages>25-53.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rietschel, E. T., Brade, H., Holst, O., Brade, L., Muller-Loennies, S., Mamat, U., Zahringer, U., Beckmann, F., Seydel, U., Brandenburg, K., Ulmer, A. J., Mattern, T., Heine, H., Schletter, J., Loppnow, H., Schonbeck, U., Flad, H. D., Hauschildt, S., Schade, U. F., Di Padova, F., Kusumoto, S., and Schumann, R. R.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immuno­logical detoxification.</articletitle>
				<worktitle>Curr Top Microbiol Immunol</worktitle>
				<number>216,</number>
				<pages>39-81.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., Ulmer, A. J., Zahringer, U., Seydel, U., Di Padova, F.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Bacterial endotoxin: molecular relationships of structure to activity and function.</articletitle>
				<worktitle>Faseb J</worktitle>
				<number>8,</number>
				<pages>217-25.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E. and Tomlanovich, M.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Early goal-directed therapy in the treatment of severe sepsis and septic shock.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>345,</number>
				<pages>1368-77.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N112E4" label="73" numbering="arabic" start="73"/>
				<workauthor>Robert, P. Y. and Adenis J. P.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Comparative review of the ophthalmic anti­bacterial preparations.</articletitle>
				<worktitle>Drugs</worktitle>
				<number>61:2,</number>
				<pages>175-85.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A., and Bazan, J. F.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>A family of human receptors structurally related to Drosophila Toll.</articletitle>
				<worktitle>Proc Natl Acad Sci USA</worktitle>
				<number>95,</number>
				<pages>588-93.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Roth, R. I., Su, D., Child, A. H., Wainwright, N. R., and Levin, J.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Limulus anti­lipopolysaccharide factor prevents mortality late in the course of endotoxemia.</articletitle>
				<worktitle>J Infect Dis</worktitle>
				<number>177,</number>
				<pages>388-94.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Schumann, R. R., Kirschning, C. J., Unbehaun, A., Aberle, H. P., Knope, H. P., Lamping, N., Ulevitch, R. J., and Herrmann, F.</workauthor>
				<pubdate>(1996).</pubdate>
				<articletitle>The lipopolysaccharide-binding protein is a secretory class 1 acute- phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins.</articletitle>
				<worktitle>Mol Cell Biol</worktitle>
				<number>16,</number>
				<pages>3490-503.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Schumann, R. R., Lamping, N. and Hoess, A.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Interchangeable endotoxin-binding domains in proteins with opposite lipopolysaccharide-dependent activities.</articletitle>
				<worktitle>J Immunol</worktitle>
				<number>159,</number>
				<pages>5599-605.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Schumann, R. R., Leong, S. R., Flaggs, G. W., Gray, P. W., Wright, S. D., Mathison, J. C., Tobias, P. S., and Ulevitch, R. J.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Structure and function of lipopoly­saccharide binding protein.</articletitle>
				<worktitle>Science</worktitle>
				<number>249,</number>
				<pages>1429-31.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Schumann, R. R., Rietschel, E. T. and Loppnow, H.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>The role of CD14 and lipopolysacchareide-binding protein (LBP) in the activation of different cell types by endotoxin.</articletitle>
				<worktitle>Med Microbiol Immunol</worktitle>
				<number>183,</number>
				<pages>279-97.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Seydel, U., Labischinski, H., Kastowsky, M., and Brandenburg, K.</workauthor>
				<pubdate>(1993).</pubdate>
				<articletitle>Phase behavior, supramolecular structure, and molecular conformation of lipopolysaccharide.</articletitle>
				<worktitle>Immunobiology</worktitle>
				<number>187,</number>
				<pages>191-211.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., and Kimoto, M.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll- like receptor 4.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>189,</number> 1777-82.</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N113B4" label="74" numbering="arabic" start="74"/>
				<workauthor>Steel, D. M., and Whitehead, A. S.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein.</articletitle>
				<worktitle>Immunol Today</worktitle>
				<number>15,</number>
				<pages>81-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Suffredini, A. F., Fantuzzi, G., Badolato, R., Oppenheim, J. J., and O'Grady, N. P.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>New insights into the biology of the acute phase response.</articletitle>
				<worktitle>J Clin Immunol</worktitle>
				<number>19,</number>
				<pages>203-14.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Takada, K., Ohno, N., and Yadomae, T.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Binding of lysozyme to lipopoly­sac­charide suppresses tumor necrosis factor production in vivo.</articletitle>
				<worktitle>Infect Immun</worktitle>
				<number>62,</number>
				<worktitle>1171-5.</worktitle>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Takeda, K., Kaisho, T. and Akira, S.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Toll-like receptors.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>21,</number>
				<pages>335-76.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Takayama, K., Mitchell, D. H., Din, Z. Z., Mukerjee, P., Li, C., and Coleman, D. L.</workauthor>
				<pubdate>(1994).</pubdate>
				<articletitle>Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>269,</number>
				<pages>2241-4.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Tall, A.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>Plasma lipid transfer proteins.</articletitle>
				<worktitle>Annu Rev Biochem</worktitle>
				<number>64,</number>
				<pages>235-57.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Tanaka, S., Nakamura, T., Morita, T., and Iwanaga, S.</workauthor>
				<pubdate>(1982).</pubdate>
				<articletitle>Limulus anti-LPS factor: an anticoagulant which inhibits the endotoxin mediated activation of Limulus coagu­lation system.</articletitle>
				<worktitle>Biochem Biophys Res Commun</worktitle>
				<number>105,</number>
				<pages>717-23.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Tobias, P. S., Mathison, J. C., and Ulevitch, R. J.</workauthor>
				<pubdate>(1988).</pubdate>
				<articletitle>A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>263,</number>
				<pages>13479-81.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Tsai, E. Y., Falvo, J. V., Tsytsykova, A. V., Barczak, A. K., Reimold, A. M., Glimcher, L. H., Fenton, M. J., Gordon, D. C., Dunn, I. F., and Goldfeld, A. E.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>A lipopoly­saccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo.</articletitle>
				<worktitle>Mol Cell Biol</worktitle>
				<number>20,</number>
				<pages>6084-94.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vallespi, M. G., Alvarez-Obregon, J. C., Rodriguez-Alonso, I., Montero, T., Garay, H., </workauthor>
				<pagenumber id="N1148A" label="75" numbering="arabic" start="75"/>
				<workauthor>Reyes, O., and Arana, M. J.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>A Limulus anti-LPS factor-derived peptide modu­lates cytokine gene expression and promotes resolution of bacterial acute infection in mice.</articletitle>
				<worktitle>Int Immunopharmacol</worktitle>
				<number>3,</number>
				<pages>247-56.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vallespi, M. G., Glaria, L. A., Reyes, O., Garay, H. E., Ferrero, J., and Arana, M. J.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>A Limulus antilipopolysaccharide factor-derived peptide exhibits a new immunological activity with potential applicability in infectious diseases.</articletitle>
				<worktitle>Clin Diagn Lab Immunol</worktitle>
				<number>7,</number>
				<pages>669-75.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P. and Bouillon, R.</workauthor>
				<pubdate>(2001).</pubdate>
				<articletitle>Intensive insulin therapy in critical ill patients.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>345,</number>
				<pages>1359-67.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>van der Bruggen, T., Nijenhuis, S., van Raaij, E., Verhoef, J., and van Asbeck, B. S.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>LPS-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway.</articletitle>
				<worktitle>Infect Immun</worktitle>
				<number>67,</number>
				<pages>3824-9.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>van der Poll, T., and van Deventer, S. J.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>Cytokines and anticytokines in the pathogenesis of sepsis.</articletitle>
				<worktitle>Infect Dis Clin North Am</worktitle>
				<number>13,</number>
				<pages>413-26.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Van Lenten, B. J., Fogelman, A. M., Haberland, M. E., and Edwards, P. A.</workauthor>
				<pubdate>(1986).</pubdate>
				<articletitle>The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide.</articletitle>
				<worktitle>Proc Natl Acad Sci USA</worktitle>
				<number>83,</number>
				<pages>2704-8.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vassalli, P.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>The pathophysiology of tumor necrosis factors.</articletitle>
				<worktitle>Annu Rev Immunol</worktitle>
				<number>10,</number>
				<pages>411-52.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vilcek, J., and Lee, T. H.</workauthor>
				<pubdate>(1991).</pubdate>
				<articletitle>Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>266,</number>
				<pages>7313-6.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vincent, J. L.</workauthor>
				<pubdate>(1998).</pubdate>
				<articletitle>Search for effective immunomodulating strategies against sepsis.</articletitle>
				<worktitle>Lancet</worktitle>
				<number>351,</number>
				<pages>922-3.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Vincent, J. L., Sun, Q., and Dubois, M. J.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Clinical trials of immunomodulatory therapies in severe sepsis and septic shock.</articletitle>
				<worktitle>Clin Infect Dis</worktitle>
				<number>34,</number>
				<pages>1084-93.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<pagenumber id="N11574" label="76" numbering="arabic" start="76"/>
				<workauthor>Volk, H.-D., Reinke, P. and Docke, W. D.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Clinical aspects: from systemic inflammation to &#8218;immunparalysis&#8216;.</articletitle>
				<worktitle>Chem Immunol</worktitle>
				<number>74,</number>
				<pages>162-77.</pages>
			</citation>
			<citation published="yes" workType="Misc">
				<workauthor>Wainwright, N. R., Miller R. J., and Paus, E.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>Endotoxin binding and neutralizing activity by a protein from Limulus polyphemus</articletitle>. <worktitle>In: Nowotny A., Spitzer J., Ziegler E. eds (Cellular and molecular aspects of endotoxin reactions. Amsterdam: Elsevier)</worktitle>
				<pages>315-25.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Warren, H. S., Suffredini, A. F., Eichacker, P. Q. and Munford, R. S.</workauthor>
				<pubdate>(2002).</pubdate>
				<articletitle>Risks and benefits of activated protein C treatment for severe sepsis.</articletitle>
				<worktitle>N Engl J Med</worktitle>
				<number>347,</number>
				<pages>1027-30.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Warren, H. S., Glennon, M. L., Wainwright, N., Amato, S. F., Black, K. M., Kirsch, S. J., Riveau, G. R., Whyte, R. I., Zapol, W. M., and Novitsky, T. J.</workauthor>
				<pubdate>(1992).</pubdate>
				<articletitle>Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor.</articletitle>
				<worktitle>Infect Immun</worktitle>
				<number>60,</number>
				<pages>2506-13.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Weiss, C. A., 3rd, Wasiluk, K. R., Kellogg, T. A., and Dunn, D. L.</workauthor>
				<pubdate>(2000).</pubdate>
				<articletitle>Bactericidal and endotoxin neutralizing activity of a peptide derived from Limulus antilipopoly­saccharide factor.</articletitle>
				<worktitle>Surgery</worktitle>
				<number>128,</number>
				<pages>339-44.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Weiss, J.</workauthor>
				<pubdate>(2003).</pubdate>
				<articletitle>Bactericidal/permeability-increasing protein (BPI) and lipopoly­saccharide-binding protein (LBP): structure, function and regulation in host defense against Gram-negative bacteria.</articletitle>
				<worktitle>Biochem Soc Trans</worktitle>
				<number>31,</number>
				<pages>785-89.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Wright, S. D. and Jong, M. T. C.</workauthor>
				<pubdate>(1986).</pubdate>
				<articletitle>Adhesion-promoting receptors on human macrophages recognize E. coli by binding to Lipopolysaccharide.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>164,</number>
				<pages>1876-88.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., and Mathison, J. C.</workauthor>
				<pubdate>(1990).</pubdate>
				<articletitle>CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.</articletitle>
				<worktitle>Science</worktitle>
				<number>249,</number>
				<pages>1431-3.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Wurfel, M. M., Hailman, E., and Wright, S. D.</workauthor>
				<pubdate>(1995).</pubdate>
				<articletitle>Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>181,</number>
				<pages>1743-54.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Wurfel, M. M., Kunitake, S. T., Lichenstein, H., Kane, J. P., and Wright, S. D.</workauthor>
				<pubdate>(1994).</pubdate>
				<pagenumber id="N1164A" label="77" numbering="arabic" start="77"/>
				<articletitle>Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.</articletitle>
				<worktitle>J Exp Med</worktitle>
				<number>180,</number>
				<pages>1025-35.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Yu, B., Hailman, E., and Wright, S. D.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.</articletitle>
				<worktitle>J Clin Invest</worktitle>
				<number>99,</number>
				<pages>315-24.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Zeni, F., Freeman, B., and Natanson, C.</workauthor>
				<pubdate>(1997).</pubdate>
				<articletitle>Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment.</articletitle>
				<worktitle>Crit Care Med</worktitle>
				<number>25,</number>
				<pages>1095-100.</pages>
			</citation>
			<citation published="yes" workType="Journal">
				<workauthor>Zhang, F. X., Kirschning, C. J., Mancinelli, R., Xu, X.-P., Jin, Y., Faure, E., Mantovani, A., Rothe, M., Muzio, M. and Arditi, M.</workauthor>
				<pubdate>(1999).</pubdate>
				<articletitle>Bacterial Lipopolysaccharide activates nuclear factor-</articletitle>
				<articletitle>&#954;</articletitle>
				<articletitle>B through Interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.</articletitle>
				<worktitle>J Biol Chem</worktitle>
				<number>274,</number>
				<pages>7611-4.</pages>
			</citation>
		</bibliography></cms:content></cms:document></cms:container>