Publikationen

Capell A., Beher D., Prokop S., Steiner H., Kaether C., Shearman M.S., Haass C. (2004) Gamma-secretase complex assembly within the early secretory pathway. in press.

Kaether C., Capell A., Edbauer D., Winkler E., Novak B., Steiner H., Haass C. (2004) The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity23(24); 4738-4748.

Peters N., Opherk C., Zacherle S., Capell A., Gempel P., Dichgans M. (2004) CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk. 299(2); 454-464.

Capell A., Kaether C., Edbauer D., Shirotani K., Merkl S., Steiner H., Haass C. (2003) Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. . 278(52); 52519-52523.

Shirotani K., Edbauer D., Capell A., Schmitz J., Steiner H., Haass C. (2003) Gamma-secretase activity is associated with a conformational change of nicastrin. 278(19); 16474-16477

Lammich S., Okochi M., Takeda M., Kaether C., Capell A., Zimmer K., Edbauer D., Walter J., Steiner H., Haass C. (2002) Presenilin dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aß-like peptide. 277(47); 44754-44759.

Kaether C., Lammich S., Edbauer D., Ertl M., Rietdorf J., Capell A., Steiner H., Haass C. (2002). Presenilin-1 affects trafficking and processing of ßAPP and is targeted in a complex with nicastrin to the plasma membrane. 158(3); 551-561

Fluhrer R., Capell A., Westmeyer G., Willem M., Hartung B., Condron M.M., Teplow D.B., Haass C., Walter J. (2002) A non-amyloidogenic function of BACE-2 in the secretory pathway. . 81(5); 1011-1020.

Moehlmann T., Winkler E., Xia X., Edbauer D., Murrell J., Capell A., Kaether C., Zheng H., Ghetti B., Haass C., Steiner H. (2002) Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aß 42 production. USA 99(12); 8025-8030.

Capell A., Meyn L., Fluhrer R., Teplow D.B., Walter J., Haass C. (2002) Apical sorting of ß-secretase limits amyloid ß-peptide production. 277(7); 5637-5643.

Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., Condron M.M., Teplow D.B., Haass C. (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. (9); 835-841.

Walter J., Fluhrer R., Hartung B., Willem M., Kaether C., Capell A., Lammich S., Multhaup G., Haass C. (2001) Phosphorylation regulates intracellular trafficking of beta-secretase. . 276(18); 14634-14641

Okochi M., Eimer S., Bottcher A., Baumeister R., Romig H., Walter J., Capell A., Steiner H., Haass C. (2000) A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Aß 42 Generation in Human Cells 275(52); 40925-40932.

Steiner H., Kostka M., Romig H., Basset G., Pesold B., Hardy J., Capell A., Meyn L., Grim M.L., Baumeister R., Fechteler K., Haass C. (2000). Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. 2(11); 848-851.

Capell A., Steiner H., Willem M., Kaiser H., Meyer C., Walter J., Lammich S., Multhaup G., Haass C. (2000) Maturation and pro-peptide cleavage of beta-secretase.275(40); 30849-30854.

Kulic L., Walter J., Multhaup G., Teplow D.B., Baumeister R., Romig H., Capell A., Steiner H., Haass C. (2000). Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. USA 23, 97(11); 5913-5918.

Capell A., Steiner H., Romig H., Keck S., Baader M., Grim MG., Baumeister R., Haass C. (2000) Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. 2(4); 205-211.

Steiner H., Capell A., Leimer U., Haass C. (1999) Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. 249(6); 266-270. Review.

Steiner H., Duff K., Capell A., Romig H., Grim M.G., Lincoln S., Hardy J., Yu X., Picciano M., Fechteler K., Citron M., Kopan R., Pesold B., Keck S., Baader M., Tomita T., Iwatsubo T., Baumeister R., Haass C. (1999) A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. . 1, 274(40); 28669-73.

Guenette S.Y., Chen J., Ferland A., Haass C., Capell A., Tanzi R.E. (1999) hFE65L influences amyloid precursor protein maturation and secretion. 73(3); 985-993.

Steiner H., Capell A., Haass C. (1999) Proteolytic processing and degradation of Alzheimer's disease relevant proteins. . 27(2); 234-242. Review.

Grünberg J., Walter J., Eckman C., Capell A., Schindzielorz A., Younkin S., Mehta N., Hardy J., Haass C. (1998) Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. 9(14); 3293-3299

Steiner H., Capell A., Pesold B., Citron M., Kloetzel P.M., Selkoe D.J., Romig H., Mendla K., Haass C. (1998) Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. 273(48); 32322-32331.

Haass C., Grunberg J., Capell A., Wild-Bode C., Leimer U., Walter J., Yamazaki T., Ihara I., Zweckbronner I., Jakubek C., Baumeister R. (1998) Proteolytic processing of Alzheimer's disease associated proteins. Suppl. 53; 159-167. Review.

Capell A., Grünberg J., Pesold B., Diehlmann A., Citron M., Nixon R., Beyreuther K., Selkoe D.J. and Haass C. (1998) The proteocytic fragments of the Alzeimer’s disease-associated presenilin-1 form heterodimers and occur as a 100-150 kDa molecular mass complex..273(6); 3205-3211

Oyama F., Sawamura N., Kobayashi K., Morisshima-Kawashima M., Kuramochi T., Ito M., Tomita T., Maruyama K., Saido T.C., Iwatsubo T., Capell A., Walter J., Gruenberg J., Ueyama Y., Haass C., Ihara Y. (1998) Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. 71(1); 313-322

Capell A., Saffrich R., Olivio J.-C., Meyn L., Walter J., Grünberg J., Dotti C. and Haass C. (1997) Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. . 69(6); 2432-2440

Tomita T., Maruyama K., Saido T., Kume H., Shinozaki K., Tokohiro S., Haass C., Capell A., Walter J., Grünberg J., Iwatsubo T. and Obata K. (1997) The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease increases the secretion of Amyloid ß-protein ending at Aß42. 94 (5); 2025-2030.

Walter J., Grünberg J., Capell A., Pesold B., Schindzierlorz A., Mendla K., St George Hyslop P., Selkoe D. J. and Haass C. (1997) Proteolytic processing of presenilin-1 generates an in vivo substrate for protein kinase C. 94 (10); 5349-5354.

Walter J., Capell A., Hung A,Y.,Langen, H., Schnölzer M., Thinakaran G., Sisodia S. S., Selkoe D.J. and Haass C. (1996) Ectodomain phosphorylation of ß-Amyloid precursor protein at two distinct cellular locations. 272(3)1896-1903

Wild-Bode C.*, Yamazaki T.*, Capell A.*, Leimer U., Steiner H., Ihara Y. and Haass C. (1997) Intracellular generation and accumulation of Amyloid ß-peptide terminating at amino acid 42. 272(26); 16085-16088.

* the first three authors contributed equally to this manuscript

Walter J., Capell A., Grünberg J., Pesold B., Schindzielorz A., Prior R., Podlisny M., Fraser P., St George Hyslop P., Selkoe D.J. and Haass C. (1996) The Alzheimer's disease associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. 2(6);673-691.

Capell A., Teplow D.B., Citron M., Selkoe D.J. and Haass C. (1996) Substitution of phenylalanine by proline at position 19 of amyloid-ß peptide results in the inhibition of protein kinase C mediated decrease of amyloidogenic processing; 3150-155.

Citron M., Diehl T.S., Capell A., Haass C., Teplow D.B. and Selkoe D.J. (1996) Inhibition of Amyloid ß-Protein production in neural cells by the serine protease inhibitor AEBSF. 17(1);171-17

Haass C., Koo E.H., Capell A., Teplow D.B. and Selkoe D.J. (1995) Polarized sorting of ß-Amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. 128(4); 537-547.

Haass C., Capell A., Citron M., Teplow D.B. and Selkoe D.J. (1995) The vacuolar H+-ATPase inhibitor Bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type ß-amyloid precursor protein. 270(11); 6186-6192.

Haass C., Lemere C.A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L. and Selkoe D.J. (1995) ß-Secretase cleavage of ß-Amyloid precursor protein with the Swedish mutation occurs within the secretory pathway after the trans-Golgi network. 1(12); 1291-1296.

München, den 24.02.2005

(Anja Capell)


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