[page 70↓]


Abe, K., K. L. Rossman, B. Liu, K. D. Ritola, D. Chiang, S. L. Campbell, K. Burridge, C. J. Der (2000). Vav2 is an activator of Cdc42, Rac1, and RhoA. J. Biol. Chem. 275, 10141-10149.

Adams, J. C. and F. M. Watt (1993). Regulation of development and differentiation by the extracellular matrix. Development 117, 1183-1198.

Adamson, E. D. (1990). Developmental activities of the epidermal growth factor receptor. Curr. Top. Dev. Biol. 24,1-29.

Aghazadeh, B., W. E. Lowry, X. Y. Huang, M. K. Rosen (2000). Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102, 625-633.

Akiyama, T., S. Matsuda, Y. Namba, T. Saito, K. Toyoshima, T. Yamamoto (1991). The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain. Mol. Cell Biol. 11, 833-842.

Araki, E., M. A. Lipes, M. E. Patti, J. C. Bruning, B. Haag, R. S. Johnson, C. R. Kahn (1994). Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186-190.

Aroian, R. V., M. Koga, J. E. Mendel, Y. Ohshima, P. W. Sternberg (1990). The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693-699.

Ausubel, F., R. Brent, R. Kingston, D. Moore, J. Smith, K. Struhl (1994). Current Protocols in Molecular Biology. John Wiley & Sons, Inc.

Awasaki, T., M. Saito, M. Sone, E. Suzuki, R. Sakai, K. Ito, C. Hama (2000). The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension. Neuron 26, 119-131.

Barcellos-Hoff, M. H., J. Aggeler, T. G. Ram, M. J. Bissell (1989). Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105, 223-235.

[page 71↓]

Bardelli, A., P. Longati, D. Gramaglia, M. C. Stella, P. M. Comoglio (1997). Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene 15, 3103-3111.

Barrett, K., M. Leptin, J. Settleman (1997). The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91, 905-915.

Bartel, P. L. and S. Fields (1995). Analyzing protein-protein interactions using two-hybrid system. Methods Enzymol. 254, 241-263.

Bateman, J., H. Shu, D. Van Vactor (2000). The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26, 93-106.

Baulida, J., M. H. Kraus, M. Alimandi, P. P. Di Fiore, G. Carpenter (1996). All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271, 5251-5257.

Bchini, O., A. C. Andres, B. Schubaur, M. Mehtali, M. LeMeur, R. Lathe, P. Gerlinger (1991). Precocious mammary gland development and milk protein synthesis in transgenic mice ubiquitously expressing human growth hormone. Endocrinology 128, 539-546.

Behrens, J., J. P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier (1996). Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638-642.

Ben-Levy, R., H. F. Paterson, C. J. Marshall, Y. Yarden (1994). A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J. 13, 3302-3311.

Berdichevsky, F., C. Gilbert, M. Shearer, J. Taylor-Papadimitriou (1992). Collagen-induced rapid morphogenesis of human mammary epithelial cells: the role of the alpha 2 beta 1 integrin. J. Cell Sci. 102, 437-446.

Billadeau, D. D., S. M. Mackie, R. A. Schoon, P. J. Leibson (2000). The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity. J. Exp. Med. 192, 381-392.

[page 72↓]

Bladt, F., D. Riethmacher, S. Isenmann, A. Aguzzi, C. Birchmeier (1995). Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376, 768-771.

Bocchinfuso, W. P. and K. S. Korach (1997). Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J. Mammary. Gland. Biol. Neoplasia. 2, 323-334.

Brisken, C., S. Park, T. Vass, J. P. Lydon, B. W. O'Malley, R. A. Weinberg (1998). A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc. Natl. Acad. Sci. U. S. A 95, 5076-5081.

Brisken, C., S. Kaur, T. E. Chavarria, N. Binart, R. L. Sutherland, R. A. Weinberg, P. A. Kelly, C. J. Ormandy (1999). Prolactin controls mammary gland development via direct and indirect mechanisms. Dev. Biol. 210, 96-106.

Brisken, C., A. Heineman, T. Chavarria, B. Elenbaas, J. Tan, S. K. Dey, J. A. McMahon, A. P. McMahon, R. A. Weinberg (2000). Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 14, 650-654.

Britsch, S., L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, D. Riethmacher (1998). The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12, 1825-1836.

Bruning, J. C., J. Winnay, B. Cheatham, C. R. Kahn (1997). Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol. Cell Biol. 17, 1513-1521.

Bustelo, X. R., J. A. Ledbetter, M. Barbacid (1992). Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature 356, 68-71.

Bustelo, X. R. (2000). Regulatory and signaling properties of the Vav family. Mol. Cell Biol. 20, 1461-1477.

Carraway, K. L., J. L. Weber, M. J. Unger, J. Ledesma, N. Yu, M. Gassmann, C. Lai (1997). Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.

Chang, H., D. J. Riese, W. Gilbert, D. F. Stern, U. J. McMahan (1997). Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 387, 509-512.

[page 73↓]

Chapman, R. S., P. C. Lourenco, E. Tonner, D. J. Flint, S. Selbert, K. Takeda, S. Akira, A. R. Clarke, C. J. Watson (1999). Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev. 13, 2604-2616.

Chiariello, M., M. J. Marinissen, J. S. Gutkind (2001). Regulation of c-myc expression by PDGF through Rho GTPases. Nat. Cell Biol. 3, 580-586.

Chodosh, L. A., H. P. Gardner, J. V. Rajan, D. B. Stairs, S. T. Marquis, P. A. Leder (2000). Protein kinase expression during murine mammary development. Dev. Biol. 219, 259-276.

Cohen, B. D., P. A. Kiener, J. M. Green, L. Foy, H. P. Fell, K. Zhang (1996). The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells. J. Biol. Chem. 271, 30897-30903.

Coleman-Krnacik, S. and J. M. Rosen (1994). Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. Mol. Endocrinol. 8, 218-229.

Crespo, P., X. R. Bustelo, D. S. Aaronson, O. A. Coso, M. Lopez-Barahona, M. Barbacid, J. S. Gutkind (1996). Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13, 455-460.

Crespo, P., K. E. Schuebel, A. A. Ostrom, J. S. Gutkind, X. R. Bustelo (1997). Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385, 169-172.

Crovello, C. S., C. Lai, L. C. Cantley, K. L. Carraway (1998). Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J. Biol. Chem. 273, 26954-26961.

Cunha, G. R. and Y. K. Hom (1996). Role of mesenchymal-epithelial interactions in mammary gland development. J. Mammary. Gland. Biol. Neoplasia. 1, 21-35.

Cunha, G. R., P. Young, Y. K. Hom, P. S. Cooke, J. A. Taylor, D. B. Lubahn (1997). Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants. J. Mammary. Gland. Biol. Neoplasia. 2, 393-402.

Dankort, D., B. Maslikowski, N. Warner, N. Kanno, H. Kim, Z. Wang, M. F. Moran, R. G. Oshima, R. D. Cardiff, W. J. Muller (2001). Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol. Cell Biol. 21, 1540-1551.

[page 74↓]

Dankort, D. L., Z. Wang, V. Blackmore, M. F. Moran, W. J. Muller (1997). Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol. Cell Biol. 17, 5410-5425.

Doody, G. M., D. D. Billadeau, E. Clayton, A. Hutchings, R. Berland, S. McAdam, P. J. Leibson, M. Turner (2000). Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J. 19, 6173-6184.

Doody, G. M., S. E. Bell, E. Vigorito, E. Clayton, S. McAdam, R. Tooze, C. Fernandez, I. J. Lee, M. Turner (2001). Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nature Immunol. 2, 542-547.

Dunbar, M. E. and J. J. Wysolmerski (1999). Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development. J. Mammary. Gland. Biol. Neoplasia. 4, 21-34.

Eaton, S., P. Auvinen, L. Luo, Y. N. Jan, K. Simons (1995). CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131, 151-164.

Eaton, S., R. Wepf, K. Simons (1996). Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J. Cell Biol. 135, 1277-1289.

Emerman, J. T. and D. R. Pitelka (1977). Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro 13, 316-328.

Erickson, S. L., K. S. O'Shea, N. Ghaboosi, L. Loverro, G. Frantz, M. Bauer, L. H. Lu, M. W. Moore (1997). ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124, 4999-5011.

Falls, D. L., K. M. Rosen, G. Corfas, W. S. Lane, G. D. Fischbach (1993). ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72, 801-815.

Faraldo, M. M., M. A. Deugnier, M. Lukashev, J. P. Thiery, M. A. Glukhova (1998). Perturbation of beta1-integrin function alters the development of murine mammary gland. EMBO J. 17, 2139-2147.

[page 75↓]

Fata, J. E., Y. Y. Kong, J. Li, T. Sasaki, J. Irie-Sasaki, R. A. Moorehead, R. Elliott, S. Scully, E. B. Voura, D. L. Lacey, W. J. Boyle, R. Khokha, J. M. Penninger (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103, 41-50.

Fazioli, F., U. H. Kim, S. G. Rhee, C. J. Molloy, O. Segatto, P. P. Di Fiore (1991). The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency. Mol. Cell Biol. 11, 2040-2048.

Fedi, P., J. H. Pierce, P. P. Di Fiore, M. H. Kraus (1994). Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members. Mol. Cell Biol. 14, 492-500.

Fields, S. and O. Song (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.

Fischer, K. D., A. Zmuldzinas, S. Gardner, M. Barbacid, A. Bernstein, C. Guidos (1995). Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature 374, 474-477.

Fischer, K. D., Y. Y. Kong, H. Nishina, K. Tedford, L. E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M. P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, J. M. Penninger (1998). Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8, 554-562.

Fixman, E. D., M. A. Naujokas, G. A. Rodrigues, M. F. Moran, M. Park (1995). Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Oncogene 10, 237-249.

Foley, J., P. Dann, J. Hong, J. Cosgrove, B. Dreyer, D. Rimm, M. Dunbar, W. Philbrick, J. Wysolmerski (2001). Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 128, 513-525.

Fowler, K. J., F. Walker, W. Alexander, M. L. Hibbs, E. C. Nice, R. M. Bohmer, G. B. Mann, C. Thumwood, R. Maglitto, J. A. Danks, a. et (1995). A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc. Natl. Acad. Sci. U. S. A 92, 1465-1469.

[page 76↓]

Freeman, M. (1998). Complexity of EGF receptor signalling revealed in Drosophila. Curr. Opin. Genet. Dev. 8, 407-411.

Freshney, N. W., S. D. Goonesekera, L. A. Feig (1997). Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain. FEBS Lett. 407, 111-115.

Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, G. Lemke (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.

Gorska, A. E., H. Joseph, R. Derynck, H. L. Moses, R. Serra (1998). Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 9, 229-238.

Graus-Porta, D., R. R. Beerli, N. E. Hynes (1995). Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol. Cell Biol. 15, 1182-1191.

Graus-Porta, D., R. R. Beerli, J. M. Daly, N. E. Hynes (1997). ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16, 1647-1655.

Grimm, J., M. Sachs, S. Britsch, S. Di Cesare, T. Schwarz-Romond, K. Alitalo, W. Birchmeier (2001). Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J. Cell Biol.(in press).

Guo, L., L. Degenstein, E. Fuchs (1996). Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 10, 165-175.

Guy, P. M., J. V. Platko, L. C. Cantley, R. A. Cerione, K. L. Carraway (1994). Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. U. S. A 91, 8132-8136.

Hacker, U. and N. Perrimon (1998). DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12, 274-284.

Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.

Harari, D., E. Tzahar, J. Romano, M. Shelly, J. H. Pierce, G. C. Andrews, Y. Yarden (1999). Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 18, 2681-2689.

[page 77↓]

Hart, M. J., A. Eva, D. Zangrilli, S. A. Aaronson, T. Evans, R. A. Cerione, Y. Zheng (1994). Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269, 62-65.

Hazan, R., B. Margolis, M. Dombalagian, A. Ullrich, A. Zilberstein, J. Schlessinger (1990). Identification of autophosphorylation sites of HER2/neu. Cell Growth Differ. 1, 3-7.

Herbst, R., P. M. Carroll, J. D. Allard, J. Schilling, T. Raabe, M. A. Simon (1996). Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85, 899-909.

Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, A. J. Wong (1996). A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379, 560-564.

Holmes, W. E., M. X. Sliwkowski, R. W. Akita, W. J. Henzel, J. Lee, J. W. Park, D. Yansura, N. Abadi, H. Raab, G. D. Lewis, a. et (1992). Identification of heregulin, a specific activator of p185erbB2. Science 256, 1205-1210.

Horseman, N. D., W. Zhao, E. Montecino-Rodriguez, M. Tanaka, K. Nakashima, S. J. Engle, F. Smith, E. Markoff, K. Dorshkind (1997). Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J. 16, 6926-6935.

Hubbard, S. R., M. Mohammadi, J. Schlessinger (1998). Autoregulatory mechanisms in protein-tyrosine kinases. J. Biol. Chem. 273, 11987-11990.

Huelsken, J. and W. Birchmeier (2001). New aspects of Wnt signaling pathways in higher vertebrates. Curr. Op. Genet. Dev. (in press).

Huelsken, J., R. Vogel, B. Erdmann, G. Cotsarelis, W. Birchmeier (2001). beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533-545.

Ihle, J. N. and I. M. Kerr (1995). Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 11, 69-74.

Imbert, A., R. Eelkema, S. Jordan, H. Feiner, P. Cowin (2001). Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J. Cell Biol. 153, 555-568.

[page 78↓]

Jackson, D., J. Bresnick, C. Dickson (1997). A role for fibroblast growth factor signaling in the lobuloalveolar development of the mammary gland. J. Mammary. Gland. Biol. Neoplasia. 2, 385-392.

Jallal, B., J. Schlessinger, A. Ullrich (1992). Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells. J. Biol. Chem. 267, 4357-4363.

Janes, P. W., R. J. Daly, A. deFazio, R. L. Sutherland (1994). Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene 9, 3601-3608.

Jhappan, C., A. G. Geiser, E. C. Kordon, D. Bagheri, L. Hennighausen, A. B. Roberts, G. H. Smith, G. Merlino (1993). Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J. 12, 1835-1845.

Jones, F. E., D. J. Jerry, B. C. Guarino, G. C. Andrews, D. F. Stern (1996). Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli. Cell Growth Differ. 7, 1031-1038.

Jones, F. E. and D. F. Stern (1999). Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation. Oncogene 18, 3481-3490.

Jones, F. E., T. Welte, X. Y. Fu, D. F. Stern (1999). ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J. Cell Biol. 147, 77-88.

Joseph, H., A. E. Gorska, P. Sohn, H. L. Moses, R. Serra (1999). Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. Mol. Biol. Cell 10, 1221-1234.

Karunagaran, D., E. Tzahar, N. Liu, D. Wen, Y. Yarden (1995). Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. J. Biol. Chem. 270, 9982-9990.

Karunagaran, D., E. Tzahar, R. R. Beerli, X. Chen, D. Graus-Porta, B. J. Ratzkin, R. Seger, N. E. Hynes, Y. Yarden (1996). ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15, 254-264.

[page 79↓]

Katoh, H., H. Yasui, Y. Yamaguchi, J. Aoki, H. Fujita, K. Mori, M. Negishi (2000). Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells. Mol. Cell Biol. 20, 7378-7387.

Katzav, S., D. Martin-Zanca, M. Barbacid (1989). vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8, 2283-2290.

Katzav, S., J. L. Cleveland, H. E. Heslop, D. Pulido (1991). Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. Mol. Cell Biol. 11, 1912-1920.

Klapper, L. N., H. Waterman, M. Sela, Y. Yarden (2000). Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60, 3384-3388.

Kleinberg, D. L. (1997). Early mammary development: growth hormone and IGF-1. J. Mammary. Gland. Biol. Neoplasia. 2, 49-57.

Kleinman, H. K., M. L. McGarvey, J. R. Hassell, V. L. Star, F. B. Cannon, G. W. Laurie, G. R. Martin (1986). Basement membrane complexes with biological activity. Biochemistry 25, 312-318.

Kodama, A., T. Matozaki, A. Fukuhara, M. Kikyo, M. Ichihashi, Y. Takai (2000). Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol. Biol. Cell 11, 2565-2575.

Kokai, Y., J. A. Cohen, J. A. Drebin, M. I. Greene (1987). Stage- and tissue-specific expression of the neu oncogene in rat development. Proc. Natl. Acad. Sci. U. S. A 84, 8498-8501.

Korach, K. S. (1994). Insights from the study of animals lacking functional estrogen receptor. Science 266, 1524-1527.

Kramer, R., N. Bucay, D. J. Kane, L. E. Martin, J. E. Tarpley, L. E. Theill (1996). Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc. Natl. Acad. Sci. U. S. A 93, 4833-4838.

Kratochwil, K. (1986). Tissue combination and organ culture studies in the development of the embryonic mammary gland. Dev. Biol. (N. Y. 1985. ) 43,15-33.

Lacey, D. L., E. Timms, H. L. Tan, M. J. Kelley, C. R. Dunstan, T. Burgess, R. Elliott, A. Colombero, G. Elliott, S. Scully, H. Hsu, J. Sullivan, N. Hawkins, E. Davy, C. Capparelli, A. Eli, Y. X. Qian, S. Kaufman, I. [page 80↓]Sarosi, V. Shalhoub, G. Senaldi, J. Guo, J. Delaney, W. J. Boyle (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176.

Lee, K. F., H. Simon, H. Chen, B. Bates, M. C. Hung, C. Hauser (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.

Lenferink, A. E., R. Pinkas-Kramarski, M. L. van de Poll, M. J. van Vugt, L. N. Klapper, E. Tzahar, H. Waterman, M. Sela, E. J. van Zoelen, Y. Yarden (1998). Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17, 3385-3397.

Levkowitz, G., H. Waterman, E. Zamir, Z. Kam, S. Oved, W. Y. Langdon, L. Beguinot, B. Geiger, Y. Yarden (1998). c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev. 12, 3663-3674.

Levkowitz, G., S. Oved, L. N. Klapper, D. Harari, S. Lavi, M. Sela, Y. Yarden (2000). c-Cbl is a suppressor of the neu oncogene. J. Biol. Chem. 275, 35532-35539.

Li, M., X. Liu, G. Robinson, U. Bar-Peled, K. U. Wagner, W. S. Young, L. Hennighausen, P. A. Furth (1997). Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc. Natl. Acad. Sci. U. S. A 94, 3425-3430.

Li, L., (2001). (submitted)

Licitra, E. J. and J. O. Liu (1996). A three-hybrid system for detecting small ligand-protein receptor interactions. Proc. Natl. Acad. Sci. U. S. A 93, 12817-12821.

Liebl, E. C., D. J. Forsthoefel, L. S. Franco, S. H. Sample, J. E. Hess, J. A. Cowger, M. P. Chandler, A. M. Shupert, M. A. Seeger (2000). Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26, 107-118.

Lin, C. Q. and M. J. Bissell (1993). Multi-faceted regulation of cell differentiation by extracellular matrix. FASEB J. 7, 737-743.

Liu, X., G. W. Robinson, K. U. Wagner, L. Garrett, A. Wynshaw-Boris, L. Hennighausen (1997). Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11, 179-186.

[page 81↓]

Lopez-Barahona, M., I. Fialka, J. M. Gonzalez-Sancho, M. Asuncion, M. Gonzalez, T. Iglesias, J. Bernal, H. Beug, A. Munoz (1995). Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells. EMBO J. 14, 1145-1155.

Lopez-Lago, M., H. Lee, C. Cruz, N. Movilla, X. R. Bustelo (2000). Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol. Cell Biol. 20, 1678-1691.

Luetteke, N. C., T. H. Qiu, R. L. Peiffer, P. Oliver, O. Smithies, D. C. Lee (1993). TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73, 263-278.

Luetteke, N. C., T. H. Qiu, S. E. Fenton, K. L. Troyer, R. F. Riedel, A. Chang, D. C. Lee (1999). Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126, 2739-2750.

Lund, L. R., J. Romer, N. Thomasset, H. Solberg, C. Pyke, M. J. Bissell, K. Dano, Z. Werb (1996). Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122, 181-193.

Lydon, J. P., F. J. DeMayo, C. R. Funk, S. K. Mani, A. R. Hughes, C. A. Montgomery, G. Shyamala, O. M. Conneely, B. W. O'Malley (1995). Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9, 2266-2278.

Mackay, D. J. and A. Hall (1998). Rho GTPases. J. Biol. Chem. 273, 20685-20688.

Magie, C. R., M. R. Meyer, M. S. Gorsuch, S. M. Parkhurst (1999). Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development. Development 126, 5353-5364.

Mann, G. B., K. J. Fowler, A. Gabriel, E. C. Nice, R. L. Williams, A. R. Dunn (1993). Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73, 249-261.

Marchionni, M. A., A. D. Goodearl, M. S. Chen, O. Bermingham-McDonogh, C. Kirk, M. Hendricks, F. Danehy, D. Misumi, J. Sudhalter, K. Kobayashi, a. et (1993). Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362, 312-318.

[page 82↓]

Margolis, B., P. Hu, S. Katzav, W. Li, J. M. Oliver, A. Ullrich, A. Weiss, J. Schlessinger (1992). Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356, 71-74.

Matsui, Y., S. A. Halter, J. T. Holt, B. L. Hogan, R. J. Coffey (1990). Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell 61, 1147-1155.

Meyer, D. and C. Birchmeier (1994). Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc. Natl. Acad. Sci. U. S. A 91, 1064-1068.

Meyer, D. and C. Birchmeier (1995). Multiple essential functions of neuregulin in development. Nature 378, 386-390.

Miettinen, P. J., J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen, Z. Werb, R. Derynck (1995). Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376, 337-341.

Moores, S. L., L. M. Selfors, J. Fredericks, T. Breit, K. Fujikawa, F. W. Alt, J. S. Brugge, W. Swat (2000). Vav family proteins couple to diverse cell surface receptors. Mol. Cell Biol. 20, 6364-6373.

Mori, S., L. Ronnstrand, K. Yokote, A. Engstrom, S. A. Courtneidge, L. Claesson-Welsh, C. H. Heldin (1993). Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J. 12, 2257-2264.

Morini, M., S. Astigiano, M. Mora, C. Ricotta, N. Ferrari, S. Mantero, G. Levi, M. Rossini, O. Barbieri (2000). Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4. Oncogene 19, 6007-6014.

Morris, J. K., W. Lin, C. Hauser, Y. Marchuk, D. Getman, K. F. Lee (1999). Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron 23, 273-283.

Movilla, N. and X. R. Bustelo (1999). Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell Biol. 19, 7870-7885.

Murphy, A. M. and D.J.Montell (1996). Cell type specific roles for Cdc42, Rac and RhoL in drosophila oogenesis. J. Cell Biol. 133, 617-630.

[page 83↓]

Muthuswamy, S. K. and W. J. Muller (1994). Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Adv. Cancer Res. 64, 111-123.

Muthuswamy, S. K. and W. J. Muller (1995a). Activation of Src family kinases in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo. Oncogene 11, 1801-1810.

Muthuswamy, S. K. and W. J. Muller (1995b). Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. Oncogene 11, 271-279.

Nemanic, M. K. and D. R. Pitelka (1971). A scanning electron microscope study of the lactating mammary gland. J. Cell Biol. 48, 410-415.

Newsome, T. P., S. Schmidt, G. Dietzl, K. Keleman, B. Asling, A. Debant, B. J. Dickson (2000). Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101, 283-294.

Nguyen, A. V. and J. W. Pollard (2000). Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution. Development 127, 3107-3118.

Nguyen, L., M. Holgado-Madruga, C. Maroun, E. D. Fixman, D. Kamikura, T. Fournier, A. Charest, M. L. Tremblay, A. J. Wong, M. Park (1997). Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356. J. Biol. Chem. 272, 20811-20819.

Niemann, C., V. Brinkmann, E. Spitzer, G. Hartmann, M. Sachs, H. Naundorf, W. Birchmeier (1998). Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J. Cell Biol. 143, 533-545.

Niranjan, B., L. Buluwela, J. Yant, N. Perusinghe, A. Atherton, D. Phippard, T. Dale, B. Gusterson, T. Kamalati (1995). HGF/SF: a potent cytokine for mammary growth, morphogenesis and development. Development 121, 2897-2908.

O'Neill, T. J., A. Craparo, T. A. Gustafson (1994). Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell Biol. 14, 6433-6442.

[page 84↓]

Olayioye, M. A., D. Graus-Porta, R. R. Beerli, J. Rohrer, B. Gay, N. E. Hynes (1998). ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell Biol. 18, 5042-5051.

Olayioye, M. A., I. Beuvink, K. Horsch, J. M. Daly, N. E. Hynes (1999). ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J. Biol. Chem. 274, 17209-17218.

Olayioye, M. A., R. M. Neve, H. A. Lane, N. E. Hynes (2000). The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19, 3159-3167.

Olson, M. F., N. G. Pasteris, J. L. Gorski, A. Hall (1996). Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6, 1628-1633.

Ormandy, C. J., A. Camus, J. Barra, D. Damotte, B. Lucas, H. Buteau, M. Edery, N. Brousse, C. Babinet, N. Binart, P. A. Kelly (1997). Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11, 167-178.

Pandey, A., A. V. Podtelejnikov, B. Blagoev, X. R. Bustelo, M. Mann, H. F. Lodish (2000). Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. Proc. Natl. Acad. Sci. U. S. A 97, 179-184.

Park, M., M. Dean, C. S. Cooper, M. Schmidt, S. J. O'Brien, D. G. Blair, G. F. Vande-Woude (1986). Mechanism of met oncogene activation. Cell 45, 895-904.

Partanen, A. M. (1990). Epidermal growth factor and transforming growth factor-alpha in the development of epithelial-mesenchymal organs of the mouse. Curr. Top. Dev. Biol. 24, 31-55.

Pasteris, N. G., A. Cadle, L. J. Logie, M. E. Porteous, C. E. Schwartz, R. E. Stevenson, T. W. Glover, R. S. Wilroy, J. L. Gorski (1994). Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor. Cell 79, 669-678.

Pawson, T. (1995). Protein modules and signalling networks. Nature 373, 573-580.

Pawson, T. and J. D. Scott (1997). Signaling through scaffold, anchoring, and adaptor proteins. Science 278, 2075-2080.

[page 85↓]

Peles, E. and Y. Yarden (1993). Neu and its ligands: from an oncogene to neural factors. Bioessays 15, 815-824.

Peles, E., R. Ben Levy, E. Tzahar, N. Liu, D. Wen, Y. Yarden (1993). Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships. EMBO J. 12, 961-971.

Pepper, M. S., J. V. Soriano, P. A. Menoud, A. P. Sappino, L. Orci, R. Montesano (1995). Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution. Exp. Cell Res. 219, 204-210.

Pierce, D. F., M. D. Johnson, Y. Matsui, S. D. Robinson, L. I. Gold, A. F. Purchio, C. W. Daniel, B. L. Hogan, H. L. Moses (1993). Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Genes Dev. 7, 2308-2317.

Pinkas-Kramarski, R., L. Soussan, H. Waterman, G. Levkowitz, I. Alroy, L. Klapper, S. Lavi, R. Seger, B. J. Ratzkin, M. Sela, Y. Yarden (1996). Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 15, 2452-2467.

Pinkas-Kramarski, R., R. Eilam, I. Alroy, G. Levkowitz, P. Lonai, Y. Yarden (1997). Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation. Oncogene 15, 2803-2815.

Pinkas-Kramarski, R., M. Shelly, B. C. Guarino, L. M. Wang, L. Lyass, I. Alroy, M. Alimandi, A. Kuo, J. D. Moyer, S. Lavi, M. Eisenstein, B. J. Ratzkin, R. Seger, S. S. Bacus, J. H. Pierce, G. C. Andrews, Y. Yarden, M. Alamandi (1998). ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol. Cell Biol. 18, 6090-6101.

Pollard, J. W. and L. Hennighausen (1994). Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc. Natl. Acad. Sci. U. S. A 91, 9312-9316.

Prigent, S. A. and W. J. Gullick (1994). Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J. 13, 2831-2841.

Qian, X., W. C. Vass, A. G. Papageorge, P. H. Anborgh, D. R. Lowy (1998). N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. Mol. Cell Biol. 18, 771-778.

[page 86↓]

Raabe, T., J. Riesgo-Escovar, X. Liu, B. S. Bausenwein, P. Deak, P. Maroy, E. Hafen (1996). DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell 85, 911-920.

Reichmann, E., R. Ball, B. Groner, R. R. Friis (1989). New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally. J. Cell Biol. 108, 1127-1138.

Ricci, A., L. Lanfrancone, R. Chiari, G. Belardo, C. Pertica, P. G. Natali, P. G. Pelicci, O. Segatto (1995). Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase. Oncogene 11, 1519-1529.

Riese, D. J., T. M. van Raaij, G. D. Plowman, G. C. Andrews, D. F. Stern (1995). The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol. Cell Biol. 15, 5770-5776.

Riese, D. J. and D. F. Stern (1998). Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20, 41-48.

Riethmacher, D., E. Sonnenberg-Riethmacher, V. Brinkmann, T. Yamaai, G. R. Lewin, C. Birchmeier (1997). Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389, 725-730.

Robinson, G. W., A. B. Karpf, K. Kratochwil (1999). Regulation of mammary gland development by tissue interaction. J. Mammary. Gland. Biol. Neoplasia. 4, 9-19.

Rodrigues, G. A. and M. Park (1993). Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol. Cell Biol. 13, 6711-6722.

Ruan, W. and D. L. Kleinberg (1999). Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140, 5075-5081.

Sachs, M., K. M. Weidner, V. Brinkmann, I. Walther, A. Obermeier, A. Ullrich, W. Birchmeier (1996). Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J. Cell Biol. 133, 1095-1107.

Sachs, M., H. Brohmann, D. Zechner, T. Muller, J. Hulsken, I. Walther, U. Schaeper, C. Birchmeier, W. Birchmeier (2000). Essential role of Gab1 for signaling by the c-Met receptor in vivo. J. Cell Biol. 150, 1375-1384.

[page 87↓]

Sakakura, T. (1987). Mammary embryogenesis. In The mammary gland: Development, regulation and function. (eds. M. C. Neville and C. W. Daniel), pp. 37-66. Plenum Press, New York.

Sandgren, E. P., J. A. Schroeder, T. H. Qui, R. D. Palmiter, R. L. Brinster, D. C. Lee (1995). Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res. 55, 3915-3927.

Sawer, R. J. and J. F. Fallon (1983). Epithelial-mesenchymal interactions in development. Praeger Publishers, New York.

Schaeffer, H. J. and M. J. Weber (1999). Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 19, 2435-2444.

Schaeper, U., N. H. Gehring, K. P. Fuchs, M. Sachs, B. Kempkes, W. Birchmeier (2000). Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J. Cell Biol. 149, 1419-1432.

Schlessinger, J. and D. Bar-Sagi (1994). Activation of Ras and other signaling pathways by receptor tyrosine kinases. Cold Spring Harb. Symp. Quant. Biol. 59, 173-179.

Schroeder, J. A. and D. C. Lee (1998). Dynamic expression and activation of ErbB receptors in the developing mouse mammary gland. Cell Growth Differ. 9, 451-464.

Schuebel, K. E., X. R. Bustelo, D. A. Nielsen, B. J. Song, M. Barbacid, D. Goldman, I. J. Lee (1996). Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene 13, 363-371.

Schuebel, K. E., N. Movilla, J. L. Rosa, X. R. Bustelo (1998). Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17, 6608-6621.

Sebastian, J., R. G. Richards, M. P. Walker, J. F. Wiesen, Z. Werb, R. Derynck, Y. K. Hom, G. R. Cunha, R. P. DiAugustine (1998). Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. Cell Growth Differ. 9, 777-785.

Segatto, O., F. Lonardo, J. H. Pierce, D. P. Bottaro, P. P. Di Fiore (1990). The role of autophosphorylation in modulation of erbB-2 transforming function. New Biol. 2, 187-195.

[page 88↓]

Segatto, O., G. Pelicci, S. Giuli, G. Digiesi, P. P. Di Fiore, J. McGlade, T. Pawson, P. G. Pelicci (1993). Shc products are substrates of erbB-2 kinase. Oncogene 8, 2105-2112.

Sibilia, M. and E. F. Wagner (1995). Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234-238.

Sibilia, M., J. P. Steinbach, L. Stingl, A. Aguzzi, E. F. Wagner (1998). A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J. 17, 719-731.

Silberstein, G. B. (2001). Postnatal mammary gland morphogenesis. Microsc. Res. Tech. 52, 155-162.

Sone, M., M. Hoshino, E. Suzuki, S. Kuroda, K. Kaibuchi, H. Nakagoshi, K. Saigo, Y. Nabeshima, C. Hama (1997). Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. Science 275, 543-547.

Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, a. et (1993). SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778.

Songyang, Z., S. E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X. R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, a. et (1994). Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol. Cell Biol. 14, 2777-2785.

Sonnenberg, A., C. J. Linders, P. W. Modderman, C. H. Damsky, M. Aumailley, R. Timpl (1990). Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. J. Cell Biol. 110, 2145-2155.

Soriano, J. V., M. S. Pepper, T. Nakamura, L. Orci, R. Montesano (1995). Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J. Cell Sci. 108, 413-430.

Stein, D., J. Wu, S. A. Fuqua, C. Roonprapunt, V. Yajnik, P. D'Eustachio, J. J. Moskow, A. M. Buchberg, C. K. Osborne, B. Margolis (1994). The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J. 13, 1331-1340.

[page 89↓]

Steven, R., T. J. Kubiseski, H. Zheng, S. Kulkarni, J. Mancillas, A. Ruiz-Morales, C. W. Hogue, T. Pawson, J. Culotti (1998). UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795.

Streuli, C. H., N. Bailey, M. J. Bissell (1991). Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. 115, 1383-1395.

Streuli, C. H., C. Schmidhauser, N. Bailey, P. Yurchenco, A. P. Skubitz, C. Roskelley, M. J. Bissell (1995a). Laminin mediates tissue-specific gene expression in mammary epithelia. J. Cell Biol. 129, 591-603.

Streuli, C. H., G. M. Edwards, M. Delcommenne, C. B. Whitelaw, T. G. Burdon, C. Schindler, C. J. Watson (1995b). Stat5 as a target for regulation by extracellular matrix. J. Biol. Chem. 270, 21639-21644.

Strutt, D. I., U. Weber, M. Mlodzik (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387, 292-295.

Sun, X. J., P. Rothenberg, C. R. Kahn, J. M. Backer, E. Araki, P. A. Wilden, D. A. Cahill, B. J. Goldstein, M. F. White (1991). Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77.

Sun, X. J., L. M. Wang, Y. Zhang, L. Yenush, M. G. Myers, E. Glasheen, W. S. Lane, J. H. Pierce, M. F. White (1995). Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.

Sweeney, C. and K. L. Carraway (2000). Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage. Oncogene 19, 5568-5573.

Tamemoto, H., T. Kadowaki, K. Tobe, T. Yagi, H. Sakura, T. Hayakawa, Y. Terauchi, K. Ueki, Y. Kaburagi, S. Satoh, a. et (1994). Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182-186.

Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, V. L. Tybulewicz (1995). Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470.

[page 90↓]

Tedford, K., L. Nitschke, I. Girkontaite, A. Charlesworth, G. Chan, V. Sakk, M. Barbacid, K. D. Fischer (2001). Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nature Immunol. 2, 548-555.

Threadgill, D. W., A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R. C. Harris, a. et (1995). Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269, 230-234.

Timpl, R. (1996). Macromolecular organization of basement membranes. Curr. Opin. Cell Biol. 8, 618-624.

Tonner, E., M. C. Barber, M. T. Travers, A. Logan, D. J. Flint (1997). Hormonal control of insulin-like growth factor-binding protein-5 production in the involuting mammary gland of the rat. Endocrinology 138, 5101-5107.

Tzahar, E., G. Levkowitz, D. Karunagaran, L. Yi, E. Peles, S. Lavi, D. Chang, N. Liu, A. Yayon, D. Wen, a. et (1994). ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. J. Biol. Chem. 269, 25226-25233.

Tzahar, E., H. Waterman, X. Chen, G. Levkowitz, D. Karunagaran, S. Lavi, B. J. Ratzkin, Y. Yarden (1996). A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell Biol. 16, 5276-5287.

Tzahar, E., R. Pinkas-Kramarski, J. D. Moyer, L. N. Klapper, I. Alroy, G. Levkowitz, M. Shelly, S. Henis, M. Eisenstein, B. J. Ratzkin, M. Sela, G. C. Andrews, Y. Yarden (1997). Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J. 16, 4938-4950.

Van Aelst, L. and C. D'Souza-Schorey (1997). Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322.

van Genderen, C., R. M. Okamura, I. Farinas, R. G. Quo, T. G. Parslow, L. Bruhn, R. Grosschedl (1994). Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8, 2691-2703.

Vonderhaar, B. K. (1987). Local effects of EGF, alpha-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo. J. Cell Physiol 132, 581-584.

[page 91↓]

Webster, M. A., R. D. Cardiff, W. J. Muller (1995). Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene. Proc. Natl. Acad. Sci. U. S. A 92, 7849-7853.

Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, W. Birchmeier (1996). Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.

Wen, D., E. Peles, R. Cupples, S. V. Suggs, S. S. Bacus, Y. Luo, G. Trail, S. Hu, S. M. Silbiger, R. Ben-Levi, R. A. Koski, H. S. Lu, Y. Yarden (1992). Neu differentiation factor: a transmembrane protein containing an EGF domain and an immunoglobulin homology unit. Cell 69, 559-572.

Wiesen, J. F., P. Young, Z. Werb, G. R. Cunha (1999). Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126, 335-344.

Withers, D. J., J. S. Gutierrez, H. Towery, D. J. Burks, J. M. Ren, S. Previs, Y. Zhang, D. Bernal, S. Pons, G. I. Shulman, S. Bonner-Weir, M. F. White (1998). Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904.

Woldeyesus, M. T., S. Britsch, D. Riethmacher, L. Xu, E. Sonnenberg-Riethmacher, F. Abou-Rebyeh, R. Harvey, P. Caroni, C. Birchmeier (1999). Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 13, 2538-2548.

Wysolmerski, J. J., W. M. Philbrick, M. E. Dunbar, B. Lanske, H. Kronenberg, A. E. Broadus (1998). Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125, 1285-1294.

Xie, W., A. J. Paterson, E. Chin, L. M. Nabell, J. E. Kudlow (1997). Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development. Mol. Endocrinol. 11, 1766-1781.

Yamauchi, T., K. Tobe, H. Tamemoto, K. Ueki, Y. Kaburagi, R. Yamamoto-Honda, Y. Takahashi, F. Yoshizawa, S. Aizawa, Y. Akanuma, N. Sonenberg, Y. Yazaki, T. Kadowaki (1996). Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell Biol. 16, 3074-3084.

[page 92↓]

Yang, Y., E. Spitzer, D. Meyer, M. Sachs, C. Niemann, G. Hartmann, K. M. Weidner, C. Birchmeier, W. Birchmeier (1995). Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol. 131, 215-226.

Yenush, L., R. Fernandez, M. G. Myers, T. C. Grammer, X. J. Sun, J. Blenis, J. H. Pierce, J. Schlessinger, M. F. White (1996). The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Mol. Cell Biol. 16, 2509-2517.

Zhang, D., M. X. Sliwkowski, M. Mark, G. Frantz, R. Akita, Y. Sun, K. Hillan, C. Crowley, J. Brush, P. J. Godowski (1997). Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci. U. S. A 94, 9562-9567.

Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, W. Swat (1995). Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470-473.

Zheng, Y., D. J. Fischer, M. F. Santos, G. Tigyi, N. G. Pasteris, J. L. Gorski, Y. Xu (1996). The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor. J. Biol. Chem. 271, 33169-33172.

Zrihan-Licht, S., B. Deng, Y. Yarden, G. McShan, I. Keydar, H. Avraham (1998). Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation. J. Biol. Chem. 273, 4065-4072.

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