<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">The Guanine Nucleotide Exchanger Vav2 Interacts with c-ErbB-2 and Induces Alveolar Morphogenesis of Mammary Epithelial Cells</cms:entry><cms:entry type="author">Silvana Di Cesare</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="N1006F" part="chapter1" ref="N1006F" type="pagenumber">3</cms:entry><cms:entry id="N10085" part="chapter1" ref="N10085" type="pagenumber">4</cms:entry><cms:entry id="N1008A" part="chapter1" ref="N1008A" type="section">1.1</cms:entry><cms:entry id="N1009B" part="chapter1" ref="N1009B" type="subsection">1.1.1</cms:entry><cms:entry id="N100A2" part="chapter1" ref="N100A2" type="pagenumber">5</cms:entry><cms:entry id="N100C4" part="chapter1" ref="N100C4" type="pagenumber">6</cms:entry><cms:entry id="N100CA" part="chapter1" ref="N100CA" type="subsection">1.1.2</cms:entry><cms:entry id="N100E3" part="chapter1" ref="N100E3" type="pagenumber">7</cms:entry><cms:entry id="N1010E" part="chapter1" ref="N1010E" type="pagenumber">8</cms:entry><cms:entry id="N10139" part="chapter1" ref="N10139" type="pagenumber">9</cms:entry><cms:entry id="N10151" part="chapter1" ref="N10151" type="subsection">1.1.3</cms:entry><cms:entry id="N10158" part="chapter1" ref="N10158" type="pagenumber">10</cms:entry><cms:entry id="N10180" part="chapter1" ref="N10180" type="pagenumber">11</cms:entry><cms:entry id="N1018A" part="chapter1" ref="N1018A" type="section">1.2</cms:entry><cms:entry id="N101A8" part="chapter1" ref="N101A8" type="pagenumber">12</cms:entry><cms:entry id="N101BC" part="chapter1" ref="N101BC" type="subsection">1.2.1</cms:entry><cms:entry id="N101C3" part="chapter1" ref="N101C3" type="pagenumber">13</cms:entry><cms:entry id="N101FB" part="chapter1" ref="N101FB" type="subsection">1.2.2</cms:entry><cms:entry id="N1020B" part="chapter1" ref="N1020B" type="pagenumber">14</cms:entry><cms:entry id="N1022D" part="chapter1" ref="N1022D" type="pagenumber">15</cms:entry><cms:entry id="N10233" part="chapter1" ref="N10233" type="subsection">1.2.3</cms:entry><cms:entry id="N10264" part="chapter1" ref="N10264" type="pagenumber">16</cms:entry><cms:entry id="N10294" part="chapter1" ref="N10294" type="subsection">1.2.4</cms:entry><cms:entry id="N102AA" part="chapter1" ref="N102AA" type="pagenumber">17</cms:entry><cms:entry id="N10311" part="chapter1" ref="N10311" type="pagenumber">18</cms:entry><cms:entry id="N10353" part="chapter1" ref="N10353" type="subsection">1.2.5</cms:entry><cms:entry id="N1035D" part="chapter1" ref="N1035D" type="pagenumber">19</cms:entry><cms:entry id="N10373" part="chapter1" ref="N10373" type="pagenumber">20</cms:entry><cms:entry id="N10392" part="chapter1" ref="N10392" type="pagenumber">21</cms:entry><cms:entry id="N103D2" part="chapter1" ref="N103D2" type="pagenumber">22</cms:entry><cms:entry id="N103F4" part="chapter1" ref="N103F4" type="pagenumber">23</cms:entry><cms:entry id="N103FB" part="chapter1" ref="N103FB" type="section">1.3</cms:entry><cms:entry id="N10444" part="chapter1" ref="N10444" type="pagenumber">24</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10452" part="chapter2" ref="N10452" type="pagenumber">25</cms:entry><cms:entry id="N1045D" part="chapter2" ref="N1045D" type="section">2.1</cms:entry><cms:entry id="N10478" part="chapter2" ref="N10478" type="section">2.2</cms:entry><cms:entry id="N10482" part="chapter2" ref="N10482" type="pagenumber">26</cms:entry><cms:entry id="N10498" part="chapter2" ref="N10498" type="pagenumber">27</cms:entry><cms:entry id="N104A1" part="chapter2" ref="N104A1" type="section">2.3</cms:entry><cms:entry id="N104AE" part="chapter2" ref="N104AE" type="pagenumber">28</cms:entry><cms:entry id="N104B4" part="chapter2" ref="N104B4" type="section">2.4</cms:entry><cms:entry id="N104D0" part="chapter2" ref="N104D0" type="pagenumber">29</cms:entry><cms:entry id="N104D6" part="chapter2" ref="N104D6" type="section">2.5</cms:entry><cms:entry id="N104E8" part="chapter2" ref="N104E8" type="section">2.6</cms:entry><cms:entry id="N104EC" part="chapter2" ref="N104EC" type="pagenumber">30</cms:entry><cms:entry id="N10503" part="chapter2" ref="N10503" type="section">2.7</cms:entry><cms:entry id="N1050D" part="chapter2" ref="N1050D" type="pagenumber">31</cms:entry><cms:entry id="N1053A" part="chapter2" ref="N1053A" type="section">2.8</cms:entry><cms:entry id="N10544" part="chapter2" ref="N10544" type="pagenumber">32</cms:entry><cms:entry id="N10550" part="chapter2" ref="N10550" type="section">2.9</cms:entry><cms:entry id="N1055F" part="chapter2" ref="N1055F" type="pagenumber">33</cms:entry><cms:entry id="N10568" part="chapter2" ref="N10568" type="section">2.10</cms:entry><cms:entry id="N1056F" part="chapter2" ref="N1056F" type="pagenumber">34</cms:entry><cms:entry id="N10575" part="chapter2" ref="N10575" type="section">2.11</cms:entry><cms:entry id="N1057E" part="chapter2" ref="N1057E" type="section">2.12</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N10592" part="chapter3" ref="N10592" type="pagenumber">35</cms:entry><cms:entry id="N10597" part="chapter3" ref="N10597" type="section">3.1</cms:entry><cms:entry id="N105AD" part="chapter3" ref="N105AD" type="pagenumber">36</cms:entry><cms:entry id="N105B4" part="chapter3" ref="N105B4" type="mm">605#168</cms:entry><cms:entry id="N105C8" part="chapter3" ref="N105C8" type="pagenumber">37</cms:entry><cms:entry id="N105D8" part="chapter3" ref="N105D8" type="table"/><cms:entry id="N106B8" part="chapter3" ref="N106B8" type="pagenumber">38</cms:entry><cms:entry id="N106BF" part="chapter3" ref="N106BF" type="mm">541#548</cms:entry><cms:entry id="N106CD" part="chapter3" ref="N106CD" type="mm">578#233</cms:entry><cms:entry id="N106DA" part="chapter3" ref="N106DA" type="section">3.2</cms:entry><cms:entry id="N106E1" part="chapter3" ref="N106E1" type="pagenumber">40</cms:entry><cms:entry id="N106E8" part="chapter3" ref="N106E8" type="table"/><cms:entry id="N10AC7" part="chapter3" ref="N10AC7" type="mm">550#186</cms:entry><cms:entry id="N10AD7" part="chapter3" ref="N10AD7" type="section">3.3</cms:entry><cms:entry id="N10ADE" part="chapter3" ref="N10ADE" type="pagenumber">42</cms:entry><cms:entry id="N10AE5" part="chapter3" ref="N10AE5" type="table"/><cms:entry id="N10F04" part="chapter3" ref="N10F04" type="pagenumber">43</cms:entry><cms:entry id="N10F0F" part="chapter3" ref="N10F0F" type="section">3.4</cms:entry><cms:entry id="N10F25" part="chapter3" ref="N10F25" type="pagenumber">44</cms:entry><cms:entry id="N10F2C" part="chapter3" ref="N10F2C" type="mm">571#606</cms:entry><cms:entry id="N10F48" part="chapter3" ref="N10F48" type="pagenumber">45</cms:entry><cms:entry id="N10F4F" part="chapter3" ref="N10F4F" type="mm">605#196</cms:entry><cms:entry id="N10F74" part="chapter3" ref="N10F74" type="pagenumber">46</cms:entry><cms:entry id="N10F7B" part="chapter3" ref="N10F7B" type="mm">447#658</cms:entry><cms:entry id="N10F9A" part="chapter3" ref="N10F9A" type="section">3.5</cms:entry><cms:entry id="N10FA7" part="chapter3" ref="N10FA7" type="pagenumber">48</cms:entry><cms:entry id="N10FAE" part="chapter3" ref="N10FAE" type="mm">605#512</cms:entry><cms:entry id="N10FC9" part="chapter3" ref="N10FC9" type="section">3.6</cms:entry><cms:entry id="N10FDC" part="chapter3" ref="N10FDC" type="pagenumber">50</cms:entry><cms:entry id="N10FE0" part="chapter3" ref="N10FE0" type="mm">485#361</cms:entry><cms:entry id="N10FED" part="chapter3" ref="N10FED" type="section">3.7</cms:entry><cms:entry id="N10FFD" part="chapter3" ref="N10FFD" type="pagenumber">51</cms:entry><cms:entry id="N1100D" part="chapter3" ref="N1100D" type="mm">453#489</cms:entry><cms:entry id="N11027" part="chapter3" ref="N11027" type="pagenumber">52</cms:entry><cms:entry id="N1102D" part="chapter3" ref="N1102D" type="section">3.8</cms:entry><cms:entry id="N1103D" part="chapter3" ref="N1103D" type="mm">605#384</cms:entry><cms:entry id="N1106C" part="chapter3" ref="N1106C" type="mm"/><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N11091" part="chapter4" ref="N11091" type="pagenumber">54</cms:entry><cms:entry id="N110AA" part="chapter4" ref="N110AA" type="section">4.1</cms:entry><cms:entry id="N110BA" part="chapter4" ref="N110BA" type="pagenumber">55</cms:entry><cms:entry id="N110C9" part="chapter4" ref="N110C9" type="section">4.2</cms:entry><cms:entry id="N110D3" part="chapter4" ref="N110D3" type="pagenumber">56</cms:entry><cms:entry id="N110DF" part="chapter4" ref="N110DF" type="section">4.3</cms:entry><cms:entry id="N110EC" part="chapter4" ref="N110EC" type="pagenumber">57</cms:entry><cms:entry id="N11117" part="chapter4" ref="N11117" type="pagenumber">58</cms:entry><cms:entry id="N1112C" part="chapter4" ref="N1112C" type="section">4.4</cms:entry><cms:entry id="N1113C" part="chapter4" ref="N1113C" type="pagenumber">59</cms:entry><cms:entry id="N11152" part="chapter4" ref="N11152" type="pagenumber">60</cms:entry><cms:entry id="N11174" part="chapter4" ref="N11174" type="pagenumber">61</cms:entry><cms:entry id="N11188" part="chapter4" ref="N11188" type="section">4.5</cms:entry><cms:entry id="N1118C" part="chapter4" ref="N1118C" type="pagenumber">62</cms:entry><cms:entry id="N111A2" part="chapter4" ref="N111A2" type="pagenumber">63</cms:entry><cms:entry id="N111ED" part="chapter4" ref="N111ED" type="section">4.6</cms:entry><cms:entry id="N111FA" part="chapter4" ref="N111FA" type="pagenumber">64</cms:entry><cms:entry id="N1123A" part="chapter4" ref="N1123A" type="pagenumber">65</cms:entry><cms:entry id="N11249" part="chapter4" ref="N11249" type="section">4.7</cms:entry><cms:entry id="N11265" part="chapter4" ref="N11265" type="pagenumber">66</cms:entry><cms:entry id="N1127B" part="chapter4" ref="N1127B" type="pagenumber">67</cms:entry><cms:entry id="N112AC" part="chapter4" ref="N112AC" type="pagenumber">68</cms:entry><cms:entry id="N112C4" part="chapter4" ref="N112C4" type="section">4.8</cms:entry><cms:entry id="N112CE" part="chapter4" ref="N112CE" type="pagenumber">69</cms:entry><cms:entry ref="N112F1" type="back"/><cms:entry id="N112F3" part="N112F3" ref="N112F3" type="bibliography">
				References</cms:entry><cms:entry id="N112F7" part="N112F3" ref="N112F7" type="pagenumber">70</cms:entry><cms:entry id="N11352" part="N112F3" ref="N11352" type="pagenumber">71</cms:entry><cms:entry id="N113B0" part="N112F3" ref="N113B0" type="pagenumber">72</cms:entry><cms:entry id="N11417" part="N112F3" ref="N11417" type="pagenumber">73</cms:entry><cms:entry id="N1147E" part="N112F3" ref="N1147E" type="pagenumber">74</cms:entry><cms:entry id="N114DC" part="N112F3" ref="N114DC" type="pagenumber">75</cms:entry><cms:entry id="N11531" part="N112F3" ref="N11531" type="pagenumber">76</cms:entry><cms:entry id="N1159E" part="N112F3" ref="N1159E" type="pagenumber">77</cms:entry><cms:entry id="N11602" part="N112F3" ref="N11602" type="pagenumber">78</cms:entry><cms:entry id="N11660" part="N112F3" ref="N11660" type="pagenumber">79</cms:entry><cms:entry id="N116C7" part="N112F3" ref="N116C7" type="pagenumber">80</cms:entry><cms:entry id="N11728" part="N112F3" ref="N11728" type="pagenumber">81</cms:entry><cms:entry id="N11786" part="N112F3" ref="N11786" type="pagenumber">82</cms:entry><cms:entry id="N117ED" part="N112F3" ref="N117ED" type="pagenumber">83</cms:entry><cms:entry id="N1184B" part="N112F3" ref="N1184B" type="pagenumber">84</cms:entry><cms:entry id="N118B2" part="N112F3" ref="N118B2" type="pagenumber">85</cms:entry><cms:entry id="N11910" part="N112F3" ref="N11910" type="pagenumber">86</cms:entry><cms:entry id="N11977" part="N112F3" ref="N11977" type="pagenumber">87</cms:entry><cms:entry id="N119D5" part="N112F3" ref="N119D5" type="pagenumber">88</cms:entry><cms:entry id="N11A33" part="N112F3" ref="N11A33" type="pagenumber">89</cms:entry><cms:entry id="N11A91" part="N112F3" ref="N11A91" type="pagenumber">90</cms:entry><cms:entry id="N11AEF" part="N112F3" ref="N11AEF" type="pagenumber">91</cms:entry><cms:entry id="N11B44" part="N112F3" ref="N11B44" type="pagenumber">92</cms:entry><cms:entry id="N11B7D" part="N11B7D" ref="N11B7D" type="abbreviation">
				Abbreviations</cms:entry><cms:entry id="N11B81" part="N11B7D" ref="N11B81" type="pagenumber">93</cms:entry><cms:entry id="N11B88" part="N11B7D" ref="N11B88" type="table"/><cms:entry id="N11DC9" part="N11B7D" ref="N11DC9" type="pagenumber">94</cms:entry><cms:entry id="N11F6D" part="N11F6D" ref="N11F6D" type="declaration">
				Erklärung</cms:entry><cms:entry id="N11F71" part="N11F6D" ref="N11F71" type="pagenumber">95</cms:entry><cms:entry ref="N11F80" type="vita">
				Curriculum Vitae</cms:entry><cms:entry ref="N11F84" type="pagenumber">96</cms:entry><cms:entry ref="N11F8B" type="table"/><cms:entry ref="N12130" type="pagenumber">97</cms:entry><cms:entry part="N11F80" type=":current"/><cms:entry type=":lang">en</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Table of contents</cms:entry><cms:entry type=":help"><url href="http://...">Help</url></cms:entry></cms:meta><cms:content><vita id="N11F80">
			<head>
				<pagenumber id="N11F84" label="96" numbering="arabic" start="96"/>Curriculum Vitae</head>
			<p>
				<table frame="none" id="N11F8B" orient="port" tocentry="1">
					<tgroup align="left" char="" charoff="50" cols="2">
						<colspec colname="1" colnum="1"/>
						<colspec colname="2" colnum="2"/>
						<tbody valign="top">
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>
										<strong>Name</strong>
									</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Di Cesare, Silvana Patricia</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>
										<strong>Date of birth </strong>
									</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>23. September 1963</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>
										<strong>Place of birth</strong>
									</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>La Plata, Argentina</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>
										<strong>Education</strong>
									</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>1968-1975</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Primary school</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Colegio Corazon Eucaristico de Jesus, La Plata</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>1976-1980</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Secondary school</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Colegio Corazon Eucaristico de Jesus, La Plata</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>1981-1989</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Studies and Graduation in Biochemistry</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Facultad de Ciencias Exactas, Universidad Nacional de La Plata</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>1992-1995</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Dissertation in Human Biology: <em>Studies of the immunoneuroendocrine interactions in an animal model of systemic lupus erythemathosus.</em>
									</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Supervisor: Prof. Dr. Hugo Besedovsky</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Philipps-Universität, Marburg</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top"/>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top">
									<p>since 1996</p>
								</entry>
								<entry morerows="0" rotate="0" valign="top">
									<p>Graduate student. Supervisor: Prof. Dr. Walter Birchmeier</p>
								</entry>
							</row>
							<row>
								<entry morerows="0" rotate="0" valign="top"/>
								<entry morerows="0" rotate="0" valign="top">
									<p>Max-Delbrück-Centrum für Molekulare Medizin, Berlin</p>
								</entry>
							</row>
						</tbody>
					</tgroup>
				</table>
			</p>
		<p><strong><pagenumber id="N12130" label="97" numbering="arabic" start="97"/>Publications</strong></p>
				
			<p>Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, W. Birchmeier (1996). Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. <em>Nature</em>
				<strong>384</strong>, 173-176.</p>
			<p>Birchmeier, W., V. Brinkmann, C. Niemann, S. Meiners, S. Di Cesare, H. Naundorf, M. Sachs (1997). Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells. In <em>Plasminogen-related growth factors </em>(eds. G. R. Bock and J. A. Goode). John Wiley and Sons Ltd, West Sussex, England. </p>
			<p>Di Cesare S., K. M. Weidner, M. Sachs, V. Brinkmann, W. Birchmeier (1996). Gab1 functionally interacts with c-Met to mediate branching morphogenesis. In <em>Mol. Biol. Cell </em>(ASCB Abstracts, Supplement to Vol.<strong> 7</strong>).</p>
			<p>Grimm, J., M. Sachs, S. Britsch, S. Di Cesare, T. Schwarz-Romond, K. Alitalo, W. Birchmeier (2001). Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. <em>J. Cell Biol.</em>
				<strong>154</strong>(2), 345-354.</p>
			<p>Di Cesare S., J. Huelsken, B. Erdmann, M. Sachs, J. Grimm, W. Birchmeier (2001). The guanine nucleotide exchange factor Vav2 induces alveolar morphogenesis of mammary gland epithelial cells. (Manuscript in preparation).</p>
			
		</vita></cms:content></cms:document></cms:container>