1 Ahlijanian MK, Barrazueta NX et al.: Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA. 2000, 97, 2910-2915,

2 Arendt T, Brückner MK et al.: Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of platsic remodeling in the adult brain. Neurosci. 1998, 43, 991-1002,

3 Auer IA, Schmidt ML et al.: Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease. Acta neuropathol. 1995, 90, 547-551,

4 Bachman DL, Wolf PA et al.: Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology. 1993, 43, 515-519,

5 Bancher C, Brunner C et al.: Accumulation of abnormally phosphorylated tau precedes formation of neurofibrillary tangles in Alzheimer's disease. Brain Res. 1989, 477, 90-99,

6 Bancher C, Jellinger K et al.: Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia. Eur Arch Psychiatry Clin Neurosci. 1996, 246, 137-146,

7 Billingsley ML, Kincaid RL: Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J. 1997, 323, 577-591,

8 Blass JP: Pathophysiology of Alzheimer's syndrome. Neurology. 1993, 43(Suppl 4), S25-S38,

9 Börnig H, Geyer G: Staining of cholesterol with the fluorescent antibiotic "filipin". Acta histochem. 1974, 50, 110-115,

10 Braak E, Braak H, Mandelkow EM: A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta neuropathol. 1994, 87, 554-567,

11 Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta neuropathol. 1991, 82, 239-259,

12 Brown MS, Goldstein JL: Multivalent feedback regulation of HMGCoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res. 1980, 21, 505-517,

13 Brown MS, Goldstein JL: A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA. 1999, 96, 11041-11048,

[Seite 52↓]

14 Carstea ED, Morris JA et al.: Niemann-Pick C1 gene: homology to mediators of cholesterol homeostasis. Sci. 1997, 277, 228-231,

15 Cataldo AM, Barnett JL et al.: Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J Neurosci. 1997, 17, 6142-6151,

16 Cataldo AM, Peterhoff CM et al.: Endocytic pathway abnormalities precede beta-amyloid deposition in sporadic Alzheimer's disease: differential effects of APOE genotype and presenilin mutations. Am J Pathol. 2000, 157, 277-286,

17 Corder EH, Saunders AM et al.: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late omset families. Sci. 1993, 261, 921-923,

18 Cruz JC, Sugii S et al.: Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol. J Biol Chem. 2000, 275, 4013-4021,

19 Davies RA, Chen FW, Ioannou YA: Transmembrane molecular pump activity of Niemann-Pick C1 protein. Sci. 2000, 290, 2295-2298,

20 Demel RA, de Kruyff B: The function of sterols in membranes. Biochim Biophys Acta. 1976, 457, 109-132,

21 Dietschy JM: Overview of cholesterol and lipoprotein metabolism in the brain, liver and extrahepatic organs. Nutr Metab Cardiovasc Dis. 1997, 7, 162-168,

22 Doll R: Review: Alzheimer's disease and environmental survival bias. Age Ageing. 1993, 22, 138-153,

23 Edlund C, Söderberg M, Kristensson K: Isoprenoids in aging and neurodegeneration. Neurochem Int. 1994, 25, 35-38,

24 Elleder M, Jirasek A, Smid F: Niemann-Pick disease (Crocker's type C) - a histochemical study of the distribution and of qualitative differences of the storage process. Acta neuropathol. 1975, 33, 191-200,

25 Elleder M, Jirasek A, Smid F et al.: Niemann-Pick disease type C - study on the nature of the cerebral storage process. Acta neuropathol. 1985, 66, 325-336,

26 Esler WP, Wolfe MS: A portrait of Alzheimer secretases - new features and familiar faces. Sci. 2001, 293, 1449-1454,

27 Fielding CJ, Fielding PE: Intracellular cholesterol transport. J Lipid Res. 1997, 38, 1503-1521,

28 Friedhoff P, von Bergen M et al.: Structure of tau protein and assembly into paired helical filaments. Biochim Biophys Acta. 2000, 1502, 122-132,

[Seite 53↓]

29 Gärtner U, Holzer M, Arendt T: Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration. Neurosci. 1999, 91, 1-5,

30 Georgieff IS, Liem RKH et al.: Expression of high molecular weight tau in the central and peripheral nervous systems. J Cell Sci. 1993, 105, 729-737,

31 Gertz HJ, Krüger H et al.: Tangle-bearing neurons show more extensive dendritic trees than tangle-free neurons in area CA1 of the hippocampus in Alzheimer's disease. Brain Res. 1991, 548, 260-266,

32 Ghetti B, Tagliavini F et al.: Gerstmann-Sträussler-Scheinker disease. II. Neurofibrillary tangles and plaques with PrP-amyloid coexist in an affected family. Neurology. 1989, 39, 1453-1461,

33 Gilbert EF, Callahan J et al.: Niemann-Pick disease type C - pathological, histochemical, ultrastructural and biochemical studies. Eur J Pediatr. 1981, 136, 263-271,

34 Goate AM: Molecular genetics of Alzheimer's disease. Geriatrics. 1997, 52, S9-S12,

35 Goedert M: Tau protein and the neurofibrillary pathology of Alzheimer's disease. Ann N Y Acad Sci. 1996, 777, 121-131,

36 Goedert M, Jakes R et al.: Assembly of microtubule-related protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature. 1996, 383, 550-553,

37 Grana X, Reddy PE: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene. 1995, 11, 211-219,

38 Grundke-Iqbal I, Iqbal K et al.: Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986, 83, 4913-4917,

39 Halliday WC, Chudley AE: 18q-syndrome: neurofibrillary tangles without neuritic plaques. J Neuropathol Exp Neurol. 1989, 48, 308,

40 Harik SI, Kalaria RN: Blood-brain border abnormalities in Alzheimer's disease. Ann N Y Acad Sci. 1991, 640, 47-52,

41 Haroutunian V, Purohit DP et al.: Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch Neurol. 1999, 56, 713-718,

42 Harzer K, Schlote W et al.: Neurovisceral lipidosis compatible with Niemann-Pick disease type C: morphological and biochemical studies of a late infantile case and enzyme and lipid assays in a prenatal case of the same family. Acta neuropathol. 1978, 43, 97-104,

[Seite 54↓]

43 Hassall DG, Graham A: Changes in free cholesterol content, measured by filipin fluorescence and flow cytometry, correlate with changes in cholesterol biosynthesis in THP-1 macrophages. Cytometry. 1995, 21, 352-362,

44 Henderson LP, Lin L et al.: Embryonic striatal neurons from Niemann-Pick type C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness. J Biol Chem. 2000, 275, 20179-29187,

45 Higgins JJ, Patterson MC et al.: A clinical staging classification for type C Niemann-Pick disease. Neurology. 1992, 42, 2286-2290,

46 Hirano A, Malamud N et al.: Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam. Arch Neurol. 1966, 15, 35-51,

47 Hof PR, Bouras C et al.: Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta neuropathol. 1992, 85, 23-30,

48 Horoupian DS, Yang SS: Paired helical filaments in neurovisceral lipidosis (juvenile dystonic lipidosis). Ann Neurol. 1978, 4, 404-411,

49 Hoyer S: Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol Scand Suppl. 1996, 165, 18-24,

50 Illenberger S, Zheng-Fischhöfer Q et al.: The endogenous and cell-cylce dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell. 1998, 9, 1495-1512,

51 Kabara JJ: A critical review of brain cholesterol metabolism. Prog Brain Res. 1973, 40, 363-382,

52 Kabouridis PS, Janzen J et al.: Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol. 2000, 30, 954-963,

53 Ko DC, Gordon MD et al.: Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. Mol Biol Cell. 2001, 12, 601-614,

54 Kölsch H, Ludwig M et al.: Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J Neural Transm. 2001, 108, 475-488,

55 Kölsch H, Lütjohann D et al.: The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Res. 1999, 818, 171-175,

56 Kruth HS, Vaughan M: Quantification of low density lipoprotein binding and cholesterol accumulation by single human fibroblasts using fluorescence microscopy. J Lipid Res. 1980, 21, 123-130,

[Seite 55↓]

57 Kunze K: Lehrbuch der Neurologie. Stuttgart, 1992

58 Lange Y, Ye J et al.: Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. J Lipid Res. 2002, 43, 198-204,

59 Lee VMY, Balin BJ et al.: A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Sci. 1991, 251, 675-678,

60 Lizard G, Gueldry S et al.: Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. FASEB J. 1998, 12, 1651-1663,

61 Love S, Bridges LR, Case CP: Neurofibrillary tangles in Niemann-Pick disease type C. Brain. 1995, 118, 119-129,

62 Lund EG, Gulleyardo JM, Russell DW: cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in brain. Proc Natl Acad Sci USA. 1999, 96, 7238-7243,

63 Lusa S, Blom TS et al.: Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. J Cell Sci. 2001, 114, 1893-1900,

64 Lütjohann D, Breuer O et al.: Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain to the circulation. Proc Natl Acad Sci USA. 1996, 93, 9799-9804,

65 Lynch C, Mobley W: Comprehensive theory of Alzheimer's disease: the effects of cholesterol on membrane receptor trafficking. Ann N Y Acad Sci. 2000, 924, 104-111,

66 Mandelkow EM, Schweers O et al.: Structure, microtubule interactions, and phosphorylation of tau protein. Ann N Y Acad Sci. 1996, 777, 96-106,

67 Markesbery WR: Oxidative stress hypothesis in Alzheimer's disease. Free Rad Biol Med. 1997, 23, 134-147,

68 Masliah E, Terry RD, Alford M et al.: Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol. 1991, 138, 235-246,

69 Masliah E, Terry RD, Mallory M et al.: Diffuse plaques do not accentuate synpase loss in Alzheimer's disease. Am J Pathol. 1990, 137, 1293-1297,

70 Mauch DH, Nägler K et al.: CNS synaptogenesis promoted by glia-derived cholesterol. Sci. 2001, 294, 1354-1357,

[Seite 56↓]

71 Mercken M, Vandermeeren M et al.: Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitopes. Acta neuropathol. 1992, 84, 265-272,

72 Mori T, Paris D et al.: Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPSW mice. J Neuropathol Exp Neurol. 2001, 60, 778-785,

73 Mortimer JA, French LR et al.: Head injury as a risk factor for Alzheimer's disease. Neurology. 1985, 35, 264-267,

74 Nagy Z, Esiri MM, Cato AM et al.: Cell cycle markers in the hippocampus in Alzheimer's disease. Acta neuropathol. 1997, 94, 6-15,

75 Nagy Z, Esiri MM, Jobst KA et al.: Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neurosci. 1995, 69, 757-761,

76 Nagy Z, Esiri MM, Smith AD: The cell division cycle and the pathophysiology of Alzheimer's disease. Neurosci. 1998, 87, 731-739,

77 Nathan BP, Bellosta S et al.: Differential aspects of apolipoproteins E3 and E4 on neuronal growth in vitro. Sci. 1994, 264, 850-852,

78 Naureckiene S, Sleat DE et al.: Identification of HE1 as the second gene of Niemann-Pick C disease. Sci. 2000, 290, 2298-2301,

79 Norman RM, Forrester RM, Tingey AH: The juvenile form of Niemann-Pick disease. Arch Dis Childh. 1967, 42, 91-96,

80 Notkola IL, Sulkava R et al.: Serum total cholesterol, apoliporotein E epsilon4 allele, and Alzheimer's disease. Neuroepidemiology. 1998, 17, 14-20,

81 Ohm TG, Braak H: Olfactory bulb changes in Alzheimer's disease. Acta neuropathol. 1987, 73, 365-369,

82 Panchuk-Voloshina N, Haugland RP et al.: Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates. J Histochem Cytochem. 1999, 47, 1179-1188,

83 Papassotiropoulos A, Lütjohann D et al.: 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiatr Res. 2002, 36, 27-32,

84 Pearson RCA, Esiri MM et al.: Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci USA. 1985, 82, 4531-4534,

85 Perez M, Cuadros R et al.: Phosphorylated, but not native, tau protein assembles following reaction wih the lipid peroxidation product, 4-hydroxy-2-nonenal. FEBS Lett. 2000, 486, 270-274,

86 Poirier J: Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. TINS. 1994, 17, 525-530,

[Seite 57↓]

87 Poirier J, Baccichet A et al.: Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neurosci. 1993, 55, 81-90,

88 Poirier J, DavignonJ et al.: Apolipoprotein E polymorphism and Alzheimer's disease. Lancet. 1993, 342, 697-699,

89 Probst A, Langui D, Ulrich J: Alzheimer's disease: a description of the structural lesions. Brain Pathol. 1991, 1, 229-239,

90 Raina AK, Hochman A et al.: Abortive apoptosis in Alzheimer's disease. Acta neuropathol. 2001, 101, 305-310,

91 Richmond W: Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem. 1973, 19, 1350-1356,

92 Sawamura N, Gong JS et al.: Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice. J Biol Chem. 2001, 276, 10314-10319,

93 Schroeder F, Holland JF, Bieber LL: Fluorometric investigations of the interaction of polyene antibiotics with sterols. Biochemistry. 1972, 11, 3105-3111,

94 Sevanian A, McLeod LL: Cholesterol autoxidation in phospholipid membrane bilayers. Lipids. 1987, 22, 627-636,

95 Severs NJ, Robenek H: Detection of microdomains in biomembranes. Biochim Biophys Acta. 1983, 737, 373-408,

96 Simons K, Ikonen E: How cells handle cholesterol. Sci. 2000, 290, 1721-1726,

97 Sparks DL: Coronary heart disease, hypertension, apoE, and cholesterol: a link to Alzheimer's disease?. Ann N Y Acad Sci. 1997, 826, 128-146,

98 Spillantini MG, Goedert M: Tau protein pathology in neurodegenerative diseases. TINS. 1998, 21, 428-433,

99 Sumpter PQ, Mann DMA et al.: An ultrastructural analysis of the effects of accumulation of neurofibrillary tangles in pyramidal neurons of the cerebral cortex in Alzheimer's disease. Neuropathol Appl Neurobiol. 1986, 12, 305-319,

100 Suzuki K, Parker CC et al.: Neurofibrillary tangles in Niemann-Pick disease type C. Acta neuropathol. 1995, 89, 227-238,

101 Svennerholm L, Gottfries CG: Membrane lipids, selectively diminished in Alzheimer brains, suggest synpase loss as a primary event in early-onset form (type 1) and demyelination in late-onset form (type 2). J Neurochem. 1994, 62, 1039-1047,

102 Vanier MT: Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature. Neurochem Res. 1999, 24, 481-489,

[Seite 58↓]

103 Vanier MT, Rodriguez-Lafrasse C et al.: Type C Niemann-Pick disease: biochemical aspects and phenotypic heterogeneity. Dev Neurosci. 1991, 13, 307-314,

10 4 Vanier MT, Suzuki K: Recent advances in elucidating Niemann-Pick C disease. Brain Pathol. 1998, 8, 163-174,

105 Vedder H, Anthes N et al.: Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system. J Neurochem. 1999, 72, 2531-2538,

106 Weaver CL, Espinoza M et al.: Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging. 2000, 21, 719-727,

107 Weis S, Weber G: Handbuch Morbus Alzheimer. Weinheim, 1997

108 Wilson DM, Binder LI: Free fatty acids stimulate the polymerization of tau and amyloid beta peptides - in vitro evidence for a common effector of pathogenesis in Alzeimer's disease. Am J Pathol. 1997, 150, 2181-2195,

109 Wisniewski K, Jervis GA et al.: Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol. 1979, 5, 288-294,

110 Wolozin B, Kellman W et al.: Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arch Neurol. 2000, 57, 1439-1443,

111 Yamada A, Saji M et al.: Progressive neuronal loss in the ventral posterior lateral and medial nuclei of thalamus in Niemann-Pick disease type C mouse brain. Brain Dev. 2001, 23, 288-297,

112 Yang Y, Geldmacher DS, Herrup K: DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci. 2001, 21, 2661-2668,

113 Yoshitake T, Kiyohara Y et al.: Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study. Neurology. 1995, 45, 1161-1168,

114 Zervas M, Dobrenis K, Walkley SU: Neurons in Niemann-Pick disease type C accumulate ganglioside as well as unesterified cholesterol and undergo dendritic and axonal alterations. J Neuropathol Exp Neurol. 2001, 60, 49-64.

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