Dittrich, Anna-Maria: Induktionsbedingungen und kostimulatorische Effekte von ICOS - einem neuen T-Zellspezifischen Oberflächenantigen



Alberola-Ila, J., Places, L., Cantrell, D.A., Vives, J. and Lozano, F . 1992 . "Intracellular Events Involved in CD5-Induced Human T Cell Activation and Proliferation." J. Immunol . 148 :1287-1293

Alderson, M.R., Tough, T.W., Davis-Smith, T., Braddy, S., Falk, B., Schooley, K.A., Goodwin, R.G., Smith, C.A., Ramsdell, F. and Lynch, D.H. 1995 . "Fas Ligand Mediates Activation-induced Cell Death in Human T Lymphocytes." J. Exp. Med. 181 :71-77

Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D. and Galibert, L. 1997 . "A homologue of the TNF receptor and ist ligand enhance T-cell growth and dendritic-cell function." Nature 390 :175-179

Arnold, B., Schönrich, G. and Hämmerling, G.J. 1993 . "Multiple levels of peripheral tolerance." Immunol. Today . 14 :12-14

Arpin, C., Déchanet, J., Van Kooten, C., Merville, P., Grouard, G., Brière, F., Banchereau, J., Liu, Y.-J. 1995 . "Generation of Memory B Cells and Plasma Cells in Vitro." Science 268 :720-722

Aversa, G., Chang, C-C.J., Carballido, J.M:, Cocks, B.G. and de Vries, J.E. 1997 . "Engagement of the Signaling Lymphocytic Activation Molecule (SLAM) on Activated T Cells Results in IL-2-Independent Cyclosporin-A-Sensitive T Cell Proliferation and IFN-gamma Production." J. Immunol . 158 :4036-4044

Azuma, M., Yssel, H., Phillips, J.H., Spits, H. and Lanier, L.L. 1993 . "Functional Expression of B7/BB1 on Activated T Lymphocytes." J. Exp. Med. 177 :845-850

Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Roussel, F., Saeland, S. 1994 . "The CD40 Antigen and Its Ligand." Ann. Rev. Immunol . 12 :881-922

Baroja, M.L., Lorre, K., Van Vaeck, F. and Ceuppens, J.L. 1989. "The Anti-T Cell Monoclonal antibody 9.3 (Anti-CD28) Provides a Helper Signal and Bypasses the Need for Accessory Cells in T Cell Activation with Immobilized Anti-CD3 and Mitogens." Cell. Immunol. 120 :205-217

Behar, B.S.M., Porcelli, S.A., Beckman, E.M. and Brenner, M.B. 1995 . "A Pathway of Costimulation That Prevents Anergy in CD28- T Cells: B7-Independent Costimulation of CD1-restricted T Cells." J. Exp. Med. 182 :2007-2018

Bich-Thuy, L.T. 1990 . "High-Affinity Receptors for Interleukin-2 Are Not Required for the Induction of Human Unstimulated B Lymphocyte Differentiation by This Lymphokine." "Cell. Immunol."


128 :22-30

Boise, L.H., Noel, P.J. and Thompson, C.B. 1995 . "CD28 and apoptosis." "Curr. Op. Immunol" . 7 :620-625

Boriello, F., Sethna, M.P., Boyd, S.D., Schweitzer, A.N., Tivol, E.A., Jacoby, D., Strom, T.B., Simpson, E.M., Freeman, G.J. and Sharpe, A.H. 1997 . "B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation." Immunity 6 :303-313

Boussiotis, V.A., Freeman, G.J., Gribben, J.G. and Nadler, L.M. 1996 . "The Role of B7-1/B7-2:CD28/CTLA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response." Immunol. Rev. 153 :5-25

Boussiotis, V.A., Freeman, G.J., Gribben, J.G. Nadler, L.M. 1995 . "The critical role of CD28 signalling in the prevention of human T-cell anergy." Res. Immunol. 146 :140-149

Boussiotis, V.A., Gribben, J.G., Freeman, G.J, Nadler, L.M. 1994 . "Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance." "Curr. Op. in Immunol." 6 :707-807

Boyum, A. 1968 . "Isolation of mononuclear cells and granulocytes from human blood." Scand. J. Clin. Invest. Suppl. 21 :977-997

Cebrián, M., Yagüe, E., Rincón, M., López-Botet, M., De Landázuri, M.O. and Sánchenz-Madrid, F. 1988 . "Triggering of T Cell Proliferation Through AIM, an Activation Inducer Molecule Expressed on Activated Human Lymphocytes." J. Exp. Med. 168 :1621-1637

Clark, E.A. and Lane, P.J. 1991 . "Regulation of Human B-Cell Activation and Adhesion." Ann. Rev. Immunol. 9 :97-127

Clark, E.A. and Ledbetter, J.A. 1994 . "How B and T cells talk to each other." Nature 367 :425-428

Cocks, B.G., Chang, C.-C.J., Caballido, J.M., Yssel, H., de Vries, J.E. and Aversa, G. 1995 ." A novel receptor involved in T-cell activation." Nature 376 :260-263

Corry, D.B., Reiner, S.L., Linsley, P.S. and Locksley, R.M. 1994 . "Differential Effects of Blockade of CD28-B7 on the Development of Th1 or Th2 Effector Cells in Experimental Leishmaniasis." J. Immunol. 153 :4142-4148

Damle, N.K. and Aruffo, A. 1991 . "Vascular cell adhesion molecule-1 induces T-cell antigen receptor-dependent activation of CD4+ T lymphocytes." Proc. natl. Acad. Sci. USA 88 :6403-6407

Damle, N.K., Klussman, K., Linsley, P.S., Aruffo, A. and Ledbetter, J.A. 1992 a. "Differential Regulatory Effects of Intercellular Adhesion Molecule-1 on Costimulation by the CD28 Counter-Receptor B7." J. Immunol. 149 :2541-2548

Damle, N.K., Klussmann, K., Leytze, G., Aruffo, A., Linsley, P.S. and Ledbetter, J.A. 1993 . "Co"


"stimulation with Integrin Ligands Intercellular Adhesion Molecule-1 or Vascular Cell Adhesion Molecule-1 Augments Activation-Induced Death of Antigen-Specific CD4+ T Lymphocytes." J. Immunol. 151 :2368-2379

Damle, N.K., Klussmann, K., Linsley, P.S. and Aruffo, A. 1992 b. "Differential Costimulatory Effects of Adhesion Molecules B7; ICAM-1, LFA-3, and VCAM-1 on Resting and Antigen-primed CD4+ T Lymphocytes." J. Immunol. 148 :1985-1992

Damle, N.K., Linsley, P.S. and Ledbetter, J.A. 1991 . "Direct helper T cell-induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7." Eur. J. Immunol. 21 :1277-1282

Dang, N.H., Torimoto, Y., Deusch, K., Schlossman, S.F. and Morimoto, C. 1990 . "Comitogenic Effect of solid-Phase Immobilized Anti-1F7 on Human CD4 T Cell Activation via CD3 and CD2 Pathways." J. Immunol. 144 :4092-4100

De Boer, M. Kasran, A., Kwekkeboom, J., Walter, H., Vandenberghe, P. and Ceuppens, J.L. 1993 . "Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells." Eur. J. Immunol. 23 :3120-3125

Del Prete, G., De Carli, M. , D´Elios, M.M., Daniel, K.C., Almerigogna, F., Alderson, M., Smith, C.A., Thomas, E. and Romagnani, S. 1995 . "CD30-mediated Signaling promotes the Development of Human T Helper Type 2-like T Cells." J. Exp. Med. 182 :1655-1661

Dhein, J., Walczak, H., Bäumler, C., Debatin, K.-H. and Krammer, P.H. 1995 . "Autocrine T cell suicide mediated by APO-1/(Fas/CD95)." Nature 373 :438-440

Ding, L. and Shevach E.M. 1996 . "Activated B Cells Express CD28/B7-Independent Costimulatory Activity." J. Immunol. 157 :1389-1396

Ding. L., Green, J.M., Thompson, C.B. and Shevach, E.M. 1995 . "B7/CD28-Dependent and -Independent Induction of CD40 Ligand Expression." J. Immunol. 155 :5124-5132

Eisen, S.A., Wednes, H.J. and Parker, C.W. 1972 . "Isolation of pure human peripheral blood T-lymphocytes using nylon wool columns." Immunol. Commun. 1 :571-577

Essery, G., Feldmann, M. and Lamb, J.R. 1988 . "Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes." Immunology . 64 :413-417

Fischer, H., Gjörloff, A., Hedlund, G., Hedman, H., Lundgren, E., Kalland, T., Sjögren, H.O. and Dohlsten, M. , 1992 . "Stimulation of Human Naive and Memory T Helper Cells with Bacterial Superantigen. Naive CD4+CD45RA+ Require a Costimulatory Signal Mediated through the LFA-1/ICAM-1 Pathway." J. Immunol. 148 :1993-1998

Fleisher, T.A. and Marti, G.E. 1992 "Detection of unseparated human lymphocytes by flow cytometry." In: Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober,


W. (Hrsg.): Current protocols in immunology . Wiley Interscience Verlag , 7.9.1.-7.9.7.

Fournel, S., Genestier, L., Robinet, E., Flacher, M. and Revillar, J.-P. 1996 . "Human T Cells Require IL-2 but Not G1/S Transition to Acquire Susceptibility to Fas-Mediated Apoptosis." J. Immunol. 157 :4309-4315

Freeman, G.J., Boussiotis, V.A., Anumanthan, A., Berstein, G.M., Ke, X.-Y., Rennert, P.D., Gray, G.S., Gribben, J.G. and Nadler, L.M. 1995 . "B7-1 and B7-2 Do Not Deliver Identical costimulatory Signals, since B7-2 but Not B7-1 Preferentially Costimulates the Initial Production of IL-4." Immunity 2 :523-532

Friccius, H., Siegels-Hübenthal, P., Rehbein, A., Schlotz, E. and Pawelec, G. 1993 . "Induction of Hyporesponsiveness in Human Lymphocytes-T Despite Their Expression of both the Co-receptor CD28 and Its Ligand B7." Cell. Immunol. 151 :283-290

Garonne, P., Neidhardt. E.-M., Garcia, E., Galibert, L., van Kooten, C. and Banchereau, J. 1995 . "Fas Ligation Induces Apoptosis of CD40-activated Human B Lymphocytes." J. Exp. Med . 182 :1265-1273

Graf, D., Müller, S., Korthäuer, U., van Kotten, C., Weise, C. and Kroczek, R.A. 1995 ." A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation." Eur. J. Immunol. 25 :1749-1754

Gray, D., Siepmann, K., Van Essen, D., Poudrier, J., Wykes, M., Jainandunsing, S., Bergthorsdottir, S. and Dullforce, P. 1996 . "B-T Lymphocyte Interactions in the Generation and Survival of Memory Cells." Immunol. Rev. 150 :45-61

Grouard, G., De Bouteiller, O., Barthelemy, C., Lebecque, S., Banchereau, J. and Liu, Y.-J. 1995 . "Regulation of Human B Cell Activation by Follicular Dendritic Cell and T Cell Signals." Curr. Top. Microbiol. Immunol. 201 :105-117

Groux, H., Torpier, G., Monté, D., Mouton, Y., Capron, A. and Ameisen, J.C. 1992 . "Activation-induced Death by Apoptosis in CD4+ T Cells from Human Immunodeficiency Virus-infected Asymptomatic Individuals." J. Exp. Med. 175 :331-340

Hirohata, S. and Shinohara, S. 1993 . "Bidirectional Modulation of Human B Cell Stimulation by Activated T Cells." Cell. Immunol. 150 :257-268

Ho., N., Gullberg. M. and Chatila, T. 1996 . "Activation Protein1-Dependent Transcriptional Activation of Interleukin 2 Gene by Ca2+/Calmodulin Kinase Type IV/Gr." J. Exp. Med. 184 :101-112

Holter, W., Majdic, O., Liszka, K., Stockinger, H. and Knapp, W. 1985 . "Kinetics of Activation Antigen Expression in Vitro-Stimulated Human T Lymphocytes." Cell. Immunol. 90 :322-330

Jelinek, D.F., Splawski, J.B. and Lipsky, P.E. 1986 . "The roles of interleukin 2 and interferon-gamma in human B cell activation, growth and differentiation." Eur. J. Immunol. 16 :925-932


Jenkins, M.K. 1994 . "The Ups and Downs of T Cell Costimulation." Immunity 1 :443-446

Ju, S.-T., Panka, D.J., Cui, H., Ettinger, R., El-Khatib, M., Sherr, D.H., Stanger, B.Z. and Marshak-Rothstein, A. 1995 . "Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation." Nature 373 :444-448

Judge, T., Tang, A., Turka, L.A. 1996 . "Immunosuppression through Blockade of CD28:B7-Mediated Costimulatory Signals." Immunol. Res. 15 :38-49

Kelsoe, G. 1996 . "Life and Death in Germinal Centers." Immunity 4 :107-111

King, C.L., Stupi, R.J., Craighead, N., June, C.H. and Typhronitis, G. 1995 . "CD28 activation promotes Th2 subset differentiation by human CD4+ cells." "Eur. J. Immunol." 25 :587-595

Klas, C., Debatin, K.-M., Jonker, R.R. and Krammer, P.H. 1993 ." Activation interferes with the Apo-1 pathway in mature human T cells." Int. Immunol. 5 :625-630

Klaus, S.J., Pinchuk, L.M., Ochs, H.D., Law, C.-L., Fanslow, W.C., Armitage, R.J. and Clark, E.A. 1994 . "Costimulation Through CD28 Enhances T Cell-Dependent B Cell Activation Via CD40-CD40L Interaction." J. Immunol. 152 :5643-5652

Kobata, T., Agematsu, K., Kameoka, J., Schlossman, S.F. and Morimoto, C. 1994 . "CD27 Is a Signal-Transducing Molecule Involved in CD45RA+ Naive T Cell Costimulation." J. Immunol. 153 :5422-5432

Koopman, G., Keehnen, R.M.J., Lindhout, E., Newman, W., Shimizu, Y., van Seventer, G.A., de Groot, C. and Pals, S.T. 1994 . "Adhesion Through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) Pathways Prevents Apoptosis of Germinal Center B Cells." J. Immunol. 152 :3760-3767

Kosco-Vilbois, M.H., Bonnefoy, J.-Y.and Chvatchko, Y. 1997 . "The physiology of murine germinal center reactions." Immunol. Rev. 156 :127-136

Krammer, P.H., Behrmann, I., Daniel, P., Dhein, J. and Debatin, K.-M. 1994 . "Regulation of apoptosis in the immune system." Curr. Op. Immunol. 6 :279-289

Kruisbeek, A.M. and Shevach, E. 1991 . "Proliferative assays for T-cell function." In: Colilgan, J.E., Kruisbeek, D.H., Margulies, D.H., Shevach, E.M. and Strober, W. (Hrsg.): Current protocols in immunology. Wiley Interscience Verlag , 3.12.1.-3.12.14

Kuiper, H.M., Lens, S.M.A., Hintzen, R.Q. and van Lier, R.A.W. 1995 . "Lymphocyte costimulation: multiple pathways, multiple functions?" Res. Immunol. 146 :180-183

Kwekkeboom, J., de Rijk, D., Kasran, A., Barcy, S., de Groot C. and de Boer, M. 1994 . "Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40L interaction." Eur. J. Immunol. 24 :508-517


Lagresle, C., Bella, C. Daniel, P.T., Krammer, P.H. and Defrance, T. 1995 . "Regulation of Germinal Center B Cell Differentiation." J. Immunol. 154 :5746-5756

Lane, P. 1997 . "Regulation of T and B Cell Responses by Modulating Interactions between CD28/CTLA4 and Their Ligand, CD80 and CD86." Annals N.Y. Acad. Sci. 815 :392-400

Lane, P. 1995 "Blocking CD28/B7 with soluble competitors: immunological phenotype of mCTLA-4Hgamma1 transgenic mice." Res. Immunol. 146 :176-179

Lane, P., Burdet, C., Hubele, S., Scheidegger, D., Müller, U., McConnell, F. and Kosco-Vilbois, M. 1994 . "B Cell Function in Mice Transgenic for mCTLA4-Hgamma1: Lack of Germinal Centers Correlated with Poor Affinity maturation and Class Switching Despite Normal Priming of CD4+ T Cells." J. Exp. Med. 179 :819-830

Lederman, S., Yellin, M.J., Cleary, A.M., Pernis, A., Inghirami, G., Cohn, L, Covey, L., Lee, J.J., Rothman, P. and Chess, L. 1994 . "T-BAM/CD40-L on Helper T Lymphocytes Augments Lymphokine-Induced B Cell Ig Isotype Switch Recombination and Rescues B Cells from Programmed Cell Death." J. Immunol. 152 :2163-2171

Lederman, S., Yellin, M.J., Krichevsky, A., Belko, J., Lee, J.J. and Chess L. 1992 . "Identification of a Novel Surface Protein on Activated CD4+ T Cells that Induces Contact-dependent B Cell Differentiation (Help)." J. Exp. Med. 175 :1091-1101

Lenschow, D.J., Walunas, T.L. and Bluestone, J.A. 1996 . "CD28/B7 System of T Cell Costimulation." Ann. Rev. Immunol. 14 :233-258

Levine, B.L., Ueda, Y., Craighead, N., Huang, M.L. and June, C.H. 1995 . "CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro." Int. Immunol. 7 :891-904

Linsley, P.S., Brady, W., Urnes, M., Grosmaire, L.S., Damle, N.K. and Ledbetter, J.A. 1991 . "CTLA-4 Is a Second Receptor for the B Cell Activation Antigen B7." J. Exp. Med. 174 :561-569

Linsley, P.S. and Ledbetter, J.A. 1993 . "The role of the CD28 receptor during T cell responses to antigen." Ann. Rev. Immunol. 11 :192-212

Lipsky, P.E. 1990 . "The Induction of Human B-Cell Activation, Proliferation and Differentiation by Anti-CD3-Stimulated T Cells-A Model of T Cell/B Cell Collaboration." Res. in Immunol . 141 :424-427

Liu, Y. and Janeway, C.A. 1992 . "Cells that can present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4+ cells." Proc. Natl. Acad. Sci. USA 89 :3845-3849

Liu, Y. and Janeway, C.A. 1990 . "IFN-gamma plays a critical role in induced cell death of effector T cells: a possible third mechanism of self-tolerance." J. Exp. Med. 172 :1735-1739


Liu, Y. and Linsley, P.S. 1992. "Costimulation of T-cell growth." Curr. Op. Immunol. 4 :265-270

Liu, Y.-J. and Arpin, C. 1997 . "Germinal center development." Immunol. Rev. 156 :111-126

Liu, Y.-J., Joshua, D.E., Williams, G.T., Smith, G.T., Gordon, J. and MacLennan, I.C.M. 1989 . "Mechanism of antigen-driven selection in germinal centres." Nature . 342 :929-931

López-Cabrera, M., Santis, A.G., Fernández-Ruiz, E., Blacher, R., Esch, F., Sánchez-Mateos, P. and Sánchez-Madrid, F. 1993 . "Molecular Cloning, Expression, and Chromosomal Localization of the Human Earliest Lymphocyte Activation Antigen AIM/CD69, a New Member of the C-Type Lectin superfamily of Signal-transmitting Receptors." J. Exp. Med. 178 :537-547

Lynch, D.H., Ramsdell, F. and Alderson, M.A. 1995 . "Fas and FasL in the homeostatic regulation of immune responses." Immunol. Today. 16 :569-574

Lucas, P.J., Negishi, I., Nakayama, K.-I., Fields, L.E. and Loh, D.Y. 1995 . "Naive CD28-Deficient T Cells Can Initiate but Not Sustain an In Vitro Antigen-Specific Immune Response." J. Immunol. 154 :5757-5768

MacLennan, I.C.M. 1994 . "Germinal Centers." Ann. Rev. Immunol. 12 :117-139

MacLennan, I.C.M., Gulbranson-Judge, A., Toellner, K.-M., Casamayor-Palleja, M., Chan, E., Sze, D.M.-Y., Luther, S.A., Orbea, H.A. 1997 . "The changing preference of T and B cells for partners as T-dependent antibody responses develop." Immunol. Rev. 156 :53-66

Manyonada, I.T., Soltys, A.J. and Hay, F.C. 1992 . "A critical evaluation of the magnetic cell sorter and ist use in the positive and negative selection of CD45RO cells." J. Immunol. Methods. 149 :1-10

Melamed, M.R., Lindmo, T. and Mendelsohn, M.L. 1990 . Flow cytometry and sorting. 2nd Ed. Wiley-Liss., Inc. , New York

Melero, I. Shuford, W.W., Newby, S.A., Aruffo, A., Ledbetter, J.A., Hellström, K.E., Mittler, R.S. and Chen, L. 1997 . "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." Nature Medicine 3 :682-685

Meyaard, L., Otto, S.A., Jonker, R.R., Mijnster, M.J., Keet, R.P.M. and Miedema, F. 1992 . "Programmed Death of T Cells in HIV-1 Infection." Science . 257 :217-219

Mittrücker, H.-W., Shahinian, A., Bouchard, D., Kündig, T.M. and Mak, T.W. 1996 . "Induction of Unresponsiveness and Impaired T cell Expansion by Staphylococcal Enterotoxin B in CD28-deficient Mice." J. Exp. Med. 183 :2481-2488

Moskophidis, D., Lechner, F., Pircher, H.-P. and Zinkernagel, R.M. 1993 . "Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector cells." Nature . 362 :758-761


Müller, D.L., Jenkins, M.K. and Schwartz, R.H. 1989 . "Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy." Ann. Rev. Immunol. 7 :445-480

Müller, S., Dorner, B., Korthäuer, U., Mages, H.W., D´Apuzzo, M., Senger, G. and Kroczek, R.A. 1995 . "Cloning of ATAC, an activation-induced, chemokine-related molecule, exclusively expressed in CD8+ T lymphocytes." Eur. J. Immunol. 25 :1744-1748

Nafaguchi, H., Suzuki, N., Mizushima, Y. and Sakane, T. 1994 . "CD28- expansions in SLE." Arthritis & Rheum. 37 :377 . (Abstr.)

Nishioka, Y. and Lipsky, P.E. 1994 . "The Role of CD40-CD40 Ligand Interaction in Human T Cell-B Cell Collaboration." J. Immunol. 153 :1027-1036

Noel, P.J., Boise, L.H. and Thompson, C.B. "Regulation of T Cell Activation By CD28 and CTLA4" in: Mechanisms of Lymphocyte Activation and Immune Regulation VI , Plenum Press , New York , 1996 a, 209-217

Noel, P.J., Boise, L.H., Green, J.M. and Thompson, C.B. 1996 b. "CD28 Costimulation Prevents Cell Death During Primary T Cell Activation." J. Immunol. 157 :636-642

Oxenius, A., Campbell, K.A., Maliszewski, C.R., Kishimoto, T. Kikutani, H., Hengartner, H., Zinkernagel, R.M. and Bachmann, M.F. 1996 . "CD40-CD40 Ligand Interactions Are Critical in T-B Cooperation but Not for Other Anti-viral CD4+ T Cell Functions." J. Exp. Med. 183 :2209-2218

Parham, P. 1983 . "On the Fragmentation of Monoclonal IgG1, IgG2a, and IgG2b From BALB/c Mice." J. Immunol. 131 :2895-2902

Palmer, E.M. and van Seventer, G.A. 1997 . "Human T Helper Cell Differentiation Is Regulated by the Combined Action of Cytokines and Accessory Cell-Dependent Costimulatory Signals." J. Immunol. 158 :2654-2662

Park, W., Weyand, C.M., Schmidt, D., Goronzy, J.J. 1997 . "Co-stimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28- T cells." Eur. J. Immunol . 27 :1082-1090

Parker, D.C. 1993 . "T Cell-Dependent B Cell Activation." Ann. Rev. Immunol. 11 :331-360

Perez, V.L., Van Parijs, L., Biuckians, A., Zheng, X.X., Strom, T.B. and Abbas, A.K. 1997 . "Induction of Peripheral T Cell Tolerance in Vivo Requires CTLA-4 Engagement." Immunity . 6 :411-417

Porstmann, T. and Kiesing, S.T. 1992 . "Enzymimmunoassay techniques: An overview." In: Friemel, H. (Hrsg.): Immunologische Arbeitsmethoden. Gustav Fischer Verlag , Jena . 2.6. 135-188

Radvanyi, L.G., Mills, G.B. and Miller, R.G. 1993 . "Religation of the T cell Receptor after Primary "


"Activation of Mature T Cells Inhibits Proliferation and Induces Apoptotic Cell Death." J Immunol. 150 :5704-5715

Ronchese, F., Hausmann, B., Hubele, S. and Lane, P. 1994 . "Mice Transgenic for a Soluble Form of Murine CTLA-4 Show Enhanced Expansion of Antigen-specific CD4+ T Cells and Defective Antibody Production In Vivo." J. Exp. Med. 179 :809-817

Sansom, D.M., Wilson, A., Boshell, M., Lewis, J. and Hall, N.D. 1993 . "B7/CD28 but not LFA-3/CD2 interactions can provide „third-party“ co-stimulation for human T-cell activation." Immunology 80 :242-247

Saukonnen, J.J., Kornfeld, H. and Berman, J.S. 1993 . "Expansion of CD8+CD28- cell population in the blood and lung of HIV-positive patients." J. Acquir. Immune Defic. Syndr. 6 :1194-1204

Schattner, E.J., Elkon, K.B., Yoo, d.-H., Tumang, J., Krammer, P.H., Crow, M.K. and Friedman, S.M. 1995 . "CD40 Ligation Induces Apo-1/Fas Expression on Human B Lymphocytes and Facilitates Apoptosis through the Apo-1/Fas Pathway." J. Exp. Med. 182 :1557-1565

Schwartz, R.H. 1996 . "Models of T Cell Anergy: Is There A Common Molecular Mechanism?" . "J. Exp. Med." 184 :1-8

Schwartz, R.H. 1990 . "A Cell Culture Model for T Lymphocyte Clonal Anergy." Science 248 :1349-1356

Shahinian, A., Pfeffer, K., Lee, K.P. Kündig, T.M., Kishihara, K. Wakeham, A., Kawai, K., Ohashi, P.S., Thompson, C.B. and Mak, T.W. 1993 . "Differential T Cell Costimulatory Requirements in CD28-Deficient Mice." Science 261 :609-612

Shanafelt, M.-C., Soderberg, C., Allsup, A., Adelman, D., Peltz, G. and Lahesmaa, R. 1995 . "Costimulatory signals Can Selectively Modulate Cytokine Production by Subsets of CD4+ T Cells." J. Immunol. 154 :1684-1690

Sideras, P., Noma, T. and Honio, T. 1988 . "Structure and Function of Interleukin 4 and 5." Immunol. Rev. 102 :189-212

Soares, L.R.B., Rivas, A., Tsavaler, L. and Engleman, E.G. 1997 . "Ligation of the V7 Molecule on T Cells Blocks Anergy Induction Through a CD28-Independent Mechanism." J Immunol. 159 :1115-1124

Splawski, J., Fu, S.M. and Lipsky, P.E. 1993 . "Immunoregulatory Role of CD40 in Human B Cell Differentiation." J. Immunol. 150 :1276-1285

Splawski, J. and Lipsky, P.E. 1991 . "Isolation of B cell populations." In: Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W. (Hrsg.): Current protocols in immunology. Wiley Interscience Verlag. , 7.5.1.-7.5.7.

Stüber, E. and Strober, W. 1996 . "The T Cell-B cell Interaction via OX40-OX40L Is Necessary for "


"the T Cell-dependent Humoral Immune Response." J. Exp. Med. 183 :979-989

Sunder-Plassman, R., Pichl, W.F., Majdic, O., Ruapp, W. and Holter, W. 1995 . "Crosslinking of CD27 in the Presence of CD28 Costimulation Results in T Cell Proliferation and Cytokine Secretion." Cell. Immunol. 164 :20-27

Thompson, C.B., Lindsten, T., Ledbetter, J., Kunkel, S.L., Young, H.A., Emerson, S.G., Leiden, J.M. and June, C.H. 1989 . "CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines / cytokines." Proc. Natl. Acad. Sci. USA 86 :1333-1337

Tivol, E.A., Schweiter, A.N. and Sharpe, A.H. , 1996 . "Costimulation and autoimmunity." Curr. Op. Immunol. 8 :822-830

Van Gool, E.A., Vandenberghe, P., de Boer, M. and Ceuppens, J.L. 1996 . "CD80, CD86 and CD40 Provide Accessory Signals in a Multiple-Step T-Cell Activation Model." Immunol. Rev. 155 :49-83

Van Seventer, G., Shimizu, Y., Horgan, K.J. and Shaw, S. 1990 . "The LFA-1 Ligand ICAM-1 Provides an Important Costimulatory Signal for T Cell Receptor-Mediated Activation of Resting T Cells." J. Immunol. 144 :4579-4586

Waterhouse, P., Marengère, L.E.M., Mittrücker, H.-W., and Mak, T.W. 1996 . "CTLA-4, a Negative Regulator of t-Lymphocyte Activation." Immunol. Rev. 153 :183-205

Wesselborg, S., Janssen, O und Kabelitz, D. 1993 . "Induction of Activation-Driven Death (Apoptosis) in Activated but Not Resting Peripheral Blood T Cells." J. Immunol . 150 :4338-4354

Weiss, A.. "T Lymphocyte Activation." In: Paul, W.E., (Hrsg.) Fundamental Immunology , 3rd Ed., Raven Press , 1993 , New York , 467-504

Wolf, H., Müller, Y., Salmen, S., Wilmanns, W. and Jung, G. 1994 . "Induction of anergy in resting human T lymphocytes by immobilized anti-CD3 antibodies." Eur. J. Immunol. 24 :1410-1417

Wong, B.R.; Rho, J. Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett III, F.S, Frankel, W.N., Lee, S.Y. and Choi, Y. 1997 . TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells. J. Bio. Chem. 272 :25190-25194

Zhang, Y.-Q., Joost van Nerven, R.J., Van Grool, S.W., Coorevits, L, de Boer, M. and Ceuppens, J.L. 1997 . "B7-CD28 interaction is a late acting co-stimulatory signal for human T cell responses." Int. Immunol. 9 :1095-1102

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