Entwicklung des perifokalen Hirnödems und Therapie mit dem selektiven Bradykinin-B₂-Rezeptor-Antagonisten LF 16.0687 Ms Beurteilung anhand magnetresonanztomographischer und gravimetrischer MethodenNils-Kristian DohseMeinen Eltern111.1231.2451.31.4671.5891.6210113123.113806#31714153.23.2.1163.2.21718311#2723.2.31920411#509213.2.4223.2.5233.2.624801#3362526273.2.73.2.8283.2.9293.2.103.2.11303.33.3.1313.3.1.132166#5333811#3083.3.1.2675#26334381#443.3.1.335746#4463.3.1.436807#53137807#53738857#138828#28839829#2903.3.240810#127413.3.2.1433#1443.3.2.242846#15343586#1333.3.34434.1444.1.145731#381754#3864.1.24.1.2.146502#37147868#43248833#41249824#4244.1.2.250649#4724.24.2.151499#3694.2.252483#338418#3144.2.34.2.3.1534.2.3.254554.2.3.3564.2.3.44.34.3.157772#5234.3.24.3.2.158543#40359625#4704.3.2.260577#4144.3.361438#3344.3.462433#4314.3.563634#45564610#4214.3.65645.15.1.165665.1.2675.1.368695.2705.2.17172735.2.2745.2.3757677785.37980815.4825.4.183661#381848586742#465875.4.288786#3248990362#24391925.4.3939495407#2975.4.4965.4.597985.55.5.1639#305991001015.5.25.5.31025.61031041056105106107LiteraturverzeichnisDanksagungErklärung an Eides StattdeInhaltsverzeichnisHilfe Literaturverzeichnis Aarabi, B. und Long, D. M. (1979): Dynamics of cerebral edema, J Neurosurg 51, Seite 779-784. Adelson, P. D.; Whalen, M. J.; Kochanek, P. M.; Robichaud, P. und Carlos, T. M. (1998): Blood brain barrier permeability and acute inflammation in two models of traumatic brain injury in the immature rat: A preliminary report, Acta Neurochir Suppl. 71, Seite 104-106. Baethmann, A (1978): Pathophysiological and pathochemical aspects of cerebral edema, Neurosurg Rev 1, Seite 85-100. Baethmann, A.; Lehr, D.; Wirth, A. und et al. (1998): Prospective analysis of patient management in severe head injury, Acta Neurochir Suppl. 71, Seite 107-110. Baethmann, A.; Maier-Hauff, K.; Schürer, L.; Lange, M.; Kempski, O. und Unterberg, A. (1983): The effect of high intracranial pressure on activation and release of mediator compounds in traumatic vasogenic brain edema, Ishii, S.; Nagai, H. und Brock, M., Intracranial Pressure V , Seite 405-412, Springer Verlag,

Berlin/Heidelberg/New York

. Baldwin, S. A.; Fugaccia, I.; Brown, D. R.; Brown, L. V. und Scheff, S. W. (1996): Blood brain barrier Breach following cortical contusion in the rat, J Neurosurg 85 [3], Seite 476-481. Barzó, P.; Marmarou, A.; Corwin, F. und Dunbar, J. G. (1997): Acute blood-brain barrier changes in experimental closed head injury as measured by mri an gd-dtpa, Acta Neurochir Suppl. 70, Seite 243-246. Barzó, P.; Marmarou, A.; Fatouros, P. und Corwin, F. (1996): MRI-monitored acute blood-brain barrier changes in experimental traumatic brain injury, J Neurosurg 85, Seite 1113-1121. Barzó, P.; Marmarou, A.; Fatouros, P.; Hayasaki, K. und Corwin, F. (1997): Biphasic pathophysiological response of vasogenic and cellular edema in traumatic brain swelling, Acta Neurochir Suppl. 70, Seite 119-122. Baskaya, M. K.; Rao, A. M.; Dogan, A. und et al (1997): The biphasic opening of the blood- brain barrier in the cortex and hippocampus after traumatic brain injury in rats, Neurosci Lett 226, Seite 33-36. Bhoola, K. D.; Evans, R. H. und Forster, M. R. (1987): Excitatory effect of bradykinin on spinal neurones, Br.J Pharmacol 90, Seite 1-15. Bhoola, K. D.; Figueroa, C. D. und Worthy, K. (1992): Bioregulation of kinins: kallikreins, kininogens, and kininases, Pharmacol Rev 44, Seite 1-80. Bryan, Jr. R. M.; Cherian, L. und Robertson, C. (1995): Regional cerebral blood flow after controlled cortical impact injury in rats, Anaesth Anlag 80, Seite 687-695. Bullock, R.; Chesnut, R. M.; Clifton, G. L.; Ghajar, J.; Marion, D. W.; Narayan, R. K.; Newell, D. W.; Pitts, L. H.; Rosner, M. J. und Willenberger, J. W. (1996): Guidelines for the management of severe head injury. Brain Trauma Foundation, Eur.J Emerg Med 3, Seite 109-127. Bullock, R.; Satharn, P.; Patterson J und et al (1990): The time course of vasogenic brain edema after focal human head injury - evidence from SPECT mapping of blood brain barrier defects, Acta Neurochir Suppl. 51, Seite 286-288. Butt, A. M. und et al (1995): Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats, Brain Res 696, Seite 145-150. Chao, J.; Swain, C. C.; Tsai, J. und Margolius, H. S. (1987): Tissue kallikrein in the rat brain and pituitary: Regional distribution and oestrogen induction in the anterior pituitary, Endocrinology 120, Seite 475-482. Chesnut, R. M.; Marshall, L. F.; Klauber, M. R.; Blunt, B. A.; Eisenberg, H. M.; Jane, J. A.; Marmarou, A. und Foulkes, M. A. (1993): The role of secondary brain injury in determining outcome from severe head injury, J Trauma 34, Seite 216-222. Cholewinski, A. J.; Stevens, G. und Wilkin, G. P. (1991): Identification of B2 bradykinin binding sites on cultured cortical astrocytes, J Neurochem 57 [4], Seite 1456-1458. Copeland, J. R.; Willoughby, K. A.; Tynan, T. M.; Moore, S. F. und Ellis, E. F. (1995): Endothelial and nonendothelial cyclooxygenase mediate rabbit pial arteriole dilation by bradykinin, Am Physiol Soc, Seite H458-H466. Cserr, H. F.; Cooper, D. N. und Milhorat, T. H. (1977): Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus, Experimental Eye Research, Suppl. 25, Seite 461-473. Davis, K. D. und Dostrovsky, J. O. (1988): Cerebrovascular application of bradykinin excites central sensory neurons, Brain Res 446, Seite 401-406. Deisenroth, K.; Meinig, G. und Schurmann, K. (1990): Dose- and time-dependent dexamethasone effects in cold lesion-induced brain edema in the rat, Neurochirurgia 33, Seite 1-7. Dixon, C. E.; Clifton, G. L.; Lighthall, J. W.; Yaghmai, A. A. und Hayes, R. L. (1991): A controlled cortical impact model of traumatic brain injury in the rat, J Neurosci Methods 39 (3), Seite 253-262. Dixon, C. E.; Lyeth, B. G.; Povlishock, J. T. und et al. (1987): A fluid percussion model of experimental brain injury in the rat, J Neurosurg 67, Seite 110-119. Doctrow, S. R.; Abelleira, S. M.; Curry, L. A. und et al (1994): The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells, Journal of Pharmacology and experimental therapeutics 271, Seite 229-237. Dodey, P.; Pruneau, D., und Barth, M.:New nonpeptide bradykinin B2 receptor antagonists (Präsentiert beim 13. französisch-japanischen Symposium Medicinal and Fine Chemistry (Mai 1998)). Elliot, K. A. C. und Jasper, H. (1949): Measurement of experimentally induced brain swelling and shrinkage, American Journal of Physiology 157, Seite 122-129. Ellis, E. F.; Chao, J. und Heizer, M. L. (1989): Brain kininogen following experimental brain injury: evidence for a secondary event, J Neurosurg 71, Seite 437-442. Ellis, E. F.; Heizer, M. L.; Hambrecht, G. S.; Holt, S. A.; Stewart, J. M. und Vavrek, R. J. (1987): Inhibition of bradykinin- and kallikrein-induced cerebral arteriolar dilatation by a specific bradykinin antagonist, Stroke 18 [4], Seite 792-795. Eriskat, J.; Schürer, L.; Kempski, O. und et al (1994): Growth kinetics of a primary brain tissue necrosis from a focal lesion, Acta Neurochir Suppl. 60, Seite 425-427. Farooqui, A. A.; Anderson, D. K.; Flynn, C.; Bradel, E.; Means, E. D. und Horrocks, L. A. (1990): Stimulation of mono- and diacylglycerol lipase activities by bradykinin in neural cultures, Biochemical and Biophysical Research Communications 166 [2], Seite 1001-1009. Feeney, D. M.; Boyeson, M. G.; Linn, R. T.; Murray, H. M. und Dail, W. G. (1981): Responses to cortical injury: I. Methodology and local effects of contusions in the rat, Brain Res 211, Seite 67-77. Feletou, M.; Germain, M.; Thuriau, C.; Fauchere, J. L. und Canet, E. (1994): Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, HOE 140, in isolated blood vessels from different species, Br J Pharmacol 112, Seite 683-689. Fior, D. R.; Martins, D. T. O. und Lindsey, C. J. (1993): Localisation of central pressor action of bradykinin in medulla oblongata, American Physiological Society, Seite H1000-H1006. Francel, P. C. (1992): Bradykinin and neuronal injury, J Neurotrauma 9, Seite 27-46. Fujiwara, Y.; Mantione, C. R. und Yamamura, H. I. (1988): Identification of B2 bradykinin binding sites in guinea-pig brain, Eur.J Pharmacol 147, Seite 487-488. Guillot, F. L. und Audus, K. L. (1990): Angiotensin peptide regulation of fluid-phase endocytosis in brain microvessel endothelial cell monolayers, J Cereb.Blood Flow Metab. 10 [6], Seite 827-834. Haberl, R. L.; Heizer, M. L. und Ellis, E. F. (1989): Laser-Doppler assessment of brain microcirculation: effect of local alterations, American Physiological Society, Seite H1255-H1260. Hall, E. D. und Braughler, J. M. (2005): Free radicals in CNS injury., Molecular and Cellular Approaches to the Treatment of Neurological Disease, Seite 81-105. Hannay, H. J.; Feldman, L.; Phan, P.; Keyani, A.; Panwar, N.; Goodman, J. C. und Robertson, C. S. (1999): Validation of a controlled cortical impact model of head injury in mice, J Neurotrauma 16 [11], Seite 1103-1114. Hayasaki, K.; Marmarou, A.; Barzo, P.; Fatouros, P. und Corwin, F. (1997): Detection of brain atrophy following traumatic brain injury using gravimetric techniques, Acta Neurochir Suppl. 70, Seite 75-77. Holodny, A. I.; Nusbaum, A. O.; Festa, S.; Pronin, I. N.; Lee, H. J. und Kalnin, A. J. (1999): Correlation between the degree of contrast enhancement and the volume of peritumoral edema in menigiomas and malignant gliomas, Neuroradiology 41, Seite 820-825. Homayoun, P. und Harik, S. I. (1991): Bradykinin receptors of cerebral microvessels stimulate phosphoinositide turnover, J.Cereb.Blood Flow Metab. 11 [4], Seite 557-566. Hösli, E. und Hösli, L. (1993): Autoradiographic localisation of binding sites for neuropeptide Y and bradykinin on astrocytes, NeuroReport 4, Seite 159-162. Ikeda, J. und Long, D. M. (1990): The molecular basis of brain injury and brain edema: the role of oxygene free radical, Neurosurg 27, Seite 1-11. Ikeda, J.; Ma, L.; Morita, I. und Murota, S. (1994): Involvement of nitric oxide and free radical (O2-) in neuronal injury induced by deprivation of oxgen and glucose in vitro, Acta Neurochir Suppl. 60, Seite 94-97. Inamura, T. und Black, K. L. (1994): Bradykinin selectively opens blood-brain barrier in experimental brain tumors, J Cereb.Blood Flow Metab. 14, Seite 862-870. Ito, J.; Marmarou, A.; Barzo, P.; Fatouros, P. und Corwin, F. (1996): Characterisation of edema by diffusion-weighted imaging in experimental traumatic brain injury, J Neurosurg 84, Seite 97-103. Kaieda, R.; Todd, M. M.; Weeks, J. B. und Warner, D. S. (1989): A Comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits, Anaesth 71, Seite 571-579. Kamitani, T.; Little, M. H. und Ellis, E. F. (1985): Evidence for a possible role of the brain kallikrein-kinin system in the modulation of the cerebral circulation, Circ Res 57 [4], Seite 545-552. Kamiya, T.; Katayama, Y.; Kashiwagi, F. und Terashi, A. (1993): The role of bradykinin in mediating ischemic brain edema in rats, Stroke 24 [4], Seite 571-576. Kariya, K.; Yamauchi, A. und Sasaki, T. (1985): Regional distribution and characterisation of kinin in the cns of the rat, J Neurochem 44 No.6, Seite 1892-1897. Katayama, Y.; Becker, D. P.; Tamura, T. und Havda, D. A. (1990): Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury, J Neurosurg 73, Seite 889-900. Katusic, Z. S.; Milde, J. H.; Cosentino, F. und Mitrovic, B. S. (1993): Subarachnoid hemorrhage and endothelial L-arginine pathway in small brain stem ateries in dogs, Stroke 24 [3], Seite 392-399. Kempski, O. (2001): Cerebral edema, Semin Nephrol 21, Seite 303-307. Kilgore, D. P.; Greger, R. K.; Daniels, D. L.; Pojunas, K. W.; Williams, A. L. und Haughton, V. M. (1987): Cranial tissues: Normal mr appearance after intravenous injection of Gd-DTPA, Radiology 160, Seite 757-761. Klatzo, I (1967): Neuropathological aspects of brain edema, Journal of Neuropathol Exp Neurology 26, Seite 1-14. Klatzo, I; Chui, E.; Fujiwara, K. und Spatz, M. (1980): Resolution of vasogenic brain edema., Adv Neurol 28, Seite 359-373. Klatzo, I. und et al (1987): Pathophysiological aspects of brain edema, Acta Neuropath 72, Seite 236-239. Kroppenstedt, S. N.; Stover, J. F. und Unterberg, A. W. (2000): Effects of dopamine on posttraumatic cerebral blood flow, brain edema, and cerebraospinal fluid glutamate and hypoxanthine concentrations, Crit Care Med 28, Seite 3792-3798. Kuroiwa, T.; Ueki, M.; Chen, Q.; Suemasu, H.; Taniguchi, I. und Okeda, R. (1994): Biomechanical characteristics of brain edema: The difference between vasogenic-type and cytotoxic-type edema, Acta Neurochir Suppl. 60, Seite 158-161. Lee, J. G.; Smith, J. J.; Hudetz, A. G.; Hillard, C. J.; Bosnjak, Z. J. und Kampine, J. P. (1995): Laser-doppler measurement of the effects of halothane and isoflurane on the cerebrovascular co2 response in the rat, Anaesth Analg 80, Seite 696-702. Lewis, R. E.; Hoffman, W. E. und Phillips, I. (1990): Angiotensin II and bradykinin: interactions between two centrally active peptides, American Physiological Society, Seite R285-R261. Lighthall, J. W. (1988): Controlled cortical impact: a new experimental brain injury model, J Neurotrauma 5, Seite 1-15. Madeddu, P.; Anania, V. und et al (1992): Role of brain kallikrein-kinin system in regulation of adrenocorticotropin release, American Journal of Physiology, Seite E312-E318. Maier-Hauff, K.; Baethmann, A.; Lange, M.; Schürer, L. und Unterberg, A. (1984): The kallikrein-kinin system as mediator in vasogenic brain edema Part2: Studies on kinin formation in focal and perifocal brain tissue, J Neurosurg 61, Seite 97-106. Marmarou, A. (1994): Traumatic brain edema: an overview, Acta Neurochir Suppl. 60, Seite 421-424. Marmarou, A.; Foda MA; van den Brink W; Campbell J; Kita H und Demetriadou K (1994): A new model of diffuse brain injury in rats. Part I: Pathophysiology an biomechanics, J Neurosurg 80 [2], Seite 291-300. Marmarou, A.; Nichols, J.; Burgess, J. und et al (1999): Effects of the bradykinin antagonist bradycor (Deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial., J Neurotrauma 16, Seite 431-444. McIntosh, T. K.; Juhler, M. und Wieloch, T. (1998): Novel pharmacologic strategies in the treatment of experimental traumatic brain injury, J Neurotrauma 15, Seite 731-766. McIntosh, T. K.; Soares, H.; Thomas, M. und Cloherty, K. (1990): Development of regional cerebral oedema after lateral fluid-percussion brain injury in the rat, Acta Neurochir Suppl. 51, Seite 263-264. Michenfelder, J. D. (1980): The cerebral circulation., The circulation in anaesthesia . Miller, R. J. (1987): Bradykinin highlights the role of phospholipid metabolism in neuronal excitability, Trends Neurol Sci 10, Seite 226. Moreau, T.; Gutman, N.; Elmoujahed, A.; Esnard, F. und Gauthier, F. (1986): Relationship between the cysteine-protease-inhibitory function of the rat t-kininogen and the release of immunoreactive kinin upon trypsin treatment, Eur J Biochem 159, Seite 341-346. Murr, R.; Schürer, L.; Berger, S.; Enzenbach, R. und Baethmann, A (1990): Effects of anaesthetic agents on cerebral blood flow and brain oedema from a focal lesion in rabbit brain, Acta Neurochir Suppl. 51, Seite 97-99. Narotam, P. K.; Rodell, T. C.; Nadvi, S. S. und et al (1999): Traumatic brain contusions: a clinical role for the kinin antagonist CP-1027, Acta Neurochir 140, Seite 793-803. Nawashiro, H.; Shima, K. und Chigasaki, H. (1994): Blood-brain barrier, cerebral blood flow, and cerebral plasma volume immediately after head injury in the rat, Acta Neurochir Suppl. 60, Seite 440-442. Ohata, K. und Marmarou, A. (1992): Clearance of brain edema an macromolecules through the cortical extracellular space, J Neurosurg 77, Seite 387-396. Pappius, H. M. und Wolfe, L. S. (1983): Effects of indomethacin and ibuprofen on cerebral metabolism and blood flow in traumatized brain, J Cereb.Blood Flow Metab. 3, Seite 448-459. Pardridge, W. M. (1999): Blood-Brain barrier biology and methodology, J Neurovir 5, Seite 556-569. Pellegrino, L. J.; Pellegrino, A. S. und Cushman, A. J. (1979): A stereotaxic atlas of the rat brain. 2nd edition. Perry, D. C. und Snyder, S. H. (1984): Identification of bradykinin in mamalian brain, J Neurochem 43 [4], Seite 1072-1080. Pickard, J. D. (1981): Role of prostaglandins and arachidonic acid derivates in the coupling of cerebral blood flow to cerebral metabolism, J Cereb.Blood Flow Metab. 1 [4], Seite 361-384. Plesnila, N.; Schulz, J.; Stoffel, M.; Eriskat, J.; Pruneau, D. und Baethmann, A (2001): Role of bradykinin B2 receptors in the formation of vasogenic brain edema in rats, J Neurotrauma 18, Seite 1049-1058. Povlishock JT (2000): Guidelines for the management of severe traumatic brain injury, J Neurotrauma 17 [6/7], Seite 453-537. Privitera, P. J.; Daum, P. R.; Hill, D. R. und Hiley, C. R. (1991): Autoradiographic visualisation and characteristics of [125 I] bradykinin binding sites in guinea pig brain, Brain Res 577, Seite 73-79. Pruneau, D.; Chorny, J.; Benkowitz, V. und et al (1999): Effect of LF 16-0687Ms, a new non peptide bradykinin B2 receptor antagonist in a rat model of closed head trauma, J Neurotrauma 16, Seite 1057-1065. Pruneau, D.; Luccarini, J. M. und Fouchet, C. (1998): LF 16.0335, a novel potent and selective nonpeptide antagonist of the human bradykinin B2 receptor, Br.J Pharmacol 125, Seite 365-372. Pruneau, D.; Paquet, J. L.; Luccarini, J. M.; Defrene, E.; Fouchet, C.; Franck, B.; Loillier, C.; Robert, C.; Cremers, B.; Vernier, M. und Dodey, P. (2000): LF 16-0687 Ms - a novel nonpeptide bradykinin B2 receptor antagonist, Restor Neurol Neurosci, Seite 177. Pruneau, D.; Paquet, J. L.; Luccarini, J. M. und et al (1999): Pharmacological profile of LF 16-0687 Ms, a new potent non-peptide bradykinin B2 receptor antagonist, Immunopharmacol 43, Seite 187-194. Raidoo, D. M. und Bhoola, K. D. (1997): Kinin receptors on human neurones, J Neuroimmunol 77, Seite 39-44. Raidoo, D. M.; Ramchurren, N.; Naidoo.Y.; Naidoo, S.; Müller-Esterl, W. und Bhoola, K. D. (1996): Visualisation of bradykinin B2 receptors on human brain neurons, Immunopharmacol 33, Seite 104-107. Rao, P. J. R. M. und Bhattacharya, S. K. (1988): Hyperthermic effect of centrally admistered bradykinin in the rat, Int Journal of Hypertermia 4, Seite 183-189. Regoli, D.; Allogho, S. N.; Rizzi, A. und et al (1998): Bradykinin receptors and their antagonists, Eur J Pharmacol 348, Seite 1-10. Regoli, K. und Barabe, J. (1980): Pharmacology of bradykinin and related kinins, Pharmacol.Rev. 32, Seite 1-46. Relton, J. K.; Beckey, V. E.; Hanson, W. L. und Whalley, E. T. (1997): CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion, Stroke 28 [7], Seite 1430-1436. Reulen, H. J.; Graham, R.; Spatz, M. und Klatzo, I. (1977): Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema, J Neurosurg 46, Seite 24-36. Rodell, T. C. und et al (1997): The kallikrein/kinin system and kinin antagonists in trauma, Immunopharmacol 333, Seite 279-283. Sanovich, E.; Bartus, R. T.; Friden, P. M.; Dean, R. L.; Le, H. Q. und Brightman, M. W. (1995): Pathway across blood-brain barrier opened by bradykinin agonist,RMP-7, Brain Res 705, Seite 125-135. Schachter, M. (1979): Kallikreins (kininogenases)- a group of serine proteases with bioregulatory actions, Pharmacological Rev 31, Seite 1-17. Schilling, L. und Wahl, M (1999): Mediators of cerebral edema, Adv Exp Med Biol 474, Seite 123-141. Schilling, L. und Wahl, M. (1997): Brain edema: Pathogenesis and therapy, Kidney Int. 51 Suppl. 59, Seite 69-75. Schilling, L. und Wahl, M. (1994): Effects of antihistaminics on experimental brain edema, Acta Neurochir Suppl. 60, Seite 79-82. Schneider, G. H.; Hennig, S.; Lanksch, W. R. und Unterberg, A. (1994): Dynamics of posttraumatic brain swelling following a cryogenic injury in rats, Acta Neurochirur 60, Seite 437-439. Schürer, L; Temesvari, P.; Wahl, M; Unterberg, A und Baethmann, A (1989): Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexametasone, Acta Neuropath 77, Seite 576-581. Shapira, Y.; Setton, D.; Artru, A. A. und Shohami, E. (1993): Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats, Anaesth Anlag 77, Seite 141-148. Shapira, Y.; Shohami, E.; Sidi, A.; Soffer, D.; Freeman, S. und Cotev, S. (1988): Experimental closed head injury in rats: Mechanical, pathophysiologic, and neurologic properties, Crit Care Med 16 [3], Seite 258-265. Smith, A. L. und Marque, J. J. (1976): Anaesthetics and cerebral edema, Anaesth 45, Seite 64. Stephens, G. J.; Marriott, D. R. und Djamgoz, M. B. A. (1993): Electrophysiological and biochemical evidence for bradykinin receptors on cultured rat cortical oligodendrocytes, Neurosci Lett 153, Seite 223-226. Stewart, J. M.; Gera, L.; Hanson WL; Zuzack, J. S.; Burkard, M.; McCullough, R. und Whalley, E. T. (1996): A new generation of bradykinin antagonists, Immunopharmacol 33, Seite 51-60. Stover, J. F.; Kroppenstedt, S. N.; Thomale, U.; Kempski, O. und Unterberg, A. W. (2000): Isoflurane doubles plasma glutamate and icreases posttraumatic brain edema, Acta Neurochir Suppl. 76, Seite 375-378. Stover, J. F.; Schöning, B.; Beyer, T. F.; Woiciechowsky, C. und Unterberg, A. W. (2000): Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-a in relation to brain edema and contusion following controlled cortical impact injury in rats, Neurosci Lett 288, Seite 25-28. Stover, J. F.; Schöning, B.; Sackowitz, O. W.; Woiciechowsky, C. und Unterberg, A. W. (2001): Effects of tacrolimus on hemispheric water content and cerebrospinal fluid levels of glutamate, hypoxanthine, interleukin-6, and tumor necrosis factor-alpha following controlled cortical impact injury in rats, J Neurosurg 94, Seite 782-787. Stover, J. F. und Unterberg, A. W. (2000): Increased cerebrospinal fluid glutamate and taurine concentrations are associated with traumatic brain edema formation in rats, Brain Res 875, Seite 51-55. Stroop, R.; Thomale, U. W.; Päuser, S.; Bernarding, J.; Vollmann, W.; Wolf, K. J. und Lanksch, W. R. (1998): Magnetic resonace imaging studies with cluster algorithm for characterisation of brain edema after controlled cortical impact injury, Acta Neurochir Suppl. 71, Seite 303-305. Sutton, R. L.; Hovda, D. A.; Adelson, P. D.; Benzel, E. C. und Becker, D. P. (1994): Metabolic changes following cortical contusion: Relationship to edema and morphological changes, Acta Neurochir Suppl. 60, Seite 446-448. Takahashi, H.; Manaka, S. und Sano, K. (1981): Changes in extracellular potassium concentration in cortex and brain stem during the acute phase of closed head injury, J Neurosurg 55, Seite 708-717. Todd, M. M. und Weeks, J. B. (1996): Comparative effects of propofol, pentobarbital, and isoflurane on cerebral blood flow and blood volume, J Neurosurg Anesthesiol, Seite 296-303. Todd, N. V. und Graham, D. I. (1990): Blood-brain barrier damage in traumatic brain contusions, Acta Neurochir Suppl. 51, Seite 296-299. Uhl, E.; Wrba, E.; Nehring, V.; Chang, R. C.; Baethmann, A. und Reulen, H. J. (1999): Technical note: a new model for quantitative analysis of brain oedema resolution into the ventricles and the subarachnoid space, Acta Neurochir 141, Seite 89-92. Unterberg, A. W. und Baethmann, A (1992): Leukotrienes and cerebral edema, J Neurosurg 76, Seite 339-341. Unterberg, A. W. und Baethmann, A. (1984): The kallikrein-kinin system as mediator in vasogenic brain edema Part1: cerebral exposure to bradykinin and plasma, J Neurosurg 61, Seite 87-96. Unterberg, A. W.; Dautermann, C.; Baethmann, A. und et al (1986): The kallikrein-kinin system as mediator in vasogenic brain edema. Part3: Inhibition of the kallikrein-kinin system in traumatic brain swelling, J Neurosurg 64, Seite 269-276. Unterberg, A. W.; Hack, U. und Baethmann, A. (1985): Blood Flow, metabolism, and function of the brain during cerebral administration of bradykinin, Adv Neurosurg 13, Seite 326-330. Unterberg, A. W.; Schmidt, W.; Dautermann, C. und Baethmann, A. (1990): The effect of various steroid treatment regimens on cold-induced brain swelling, Acta Neurochir Suppl. 51, Seite 104-106. Unterberg, A. W.; Stroop, R. und Thomale, U. (1997): Characterisation of brain edema following controlled cortical impact injury in rats, Acta Neurochir Suppl. 70, Seite 106-108. Unterberg, A. W.; Wahl, M. und Baethmann, A. (1984): Effects of bradykinin on permeability and diameter of pial vessels in vivo, J Cereb.Blood Flow Metab. 4, Seite 574-585. Unterberg, A. W.; Wahl, M. und Baethmann, A. (1983): Bradykinin as a mediator in vasogenic brain edema: effects on blood brain barrier function and pial microcirculation, Adv Neurosurg 11, Seite 355-358. Unterberg, A. W.; Wahl, M.; Hammersen, F. und Baethmann, A. (1987): Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid, Acta Neuropath (Berl) 73 [3], Seite 209-219. Van den Brink, W. A.; Marmarou, A. und Avezaat, C. J. J. (1990): Brain edema in experimental closed head injury in the rat, Acta Neurochir Suppl. 51, Seite 261-262. Van den Brink, W. A.; Santos, B. O.; Marmarou, A. und Avezaat, C. J. J. (1994): Quantitative analysis of blood-brain barrier damage in two models of experimental head injury in the rat, Acta Neurochir Suppl. 60, Seite 456-458. Vorbrodt, A. W.; Lossinsky, A. S.; Wisniewski, H. M.; Suzuki, T.; Yamaguchi, T.; Masaoka, H. und Klatzo, I. (1985): Ultrastructural observations on the transvascular route of protein removal in vasogenic brain edema, Acta Neuropath 66, Seite 265-273. Wahl, M.; Schilling, L.; Unterberg AW und Baethmann, A. (1993): Mediators of Vascular and Parenchymal Mechanisms in Secondary Brain Damage, Acta Neurochir Suppl. 57, Seite 64-72. Wahl, M.; Unterberg, A. und Baethmann, A. (1985): Intravital flourescence microscopy for the study of blood-brain-barrier function, Int.J Microcirc 4, Seite 3-18. Wahl, M.; Whalley, E. T.; Unterberg, A.; Schilling, L.; Parsons, A. A.; Baethmann, A. und Young, A. R. (1996): Vasomotor and permeability effects of bradykinin in the cerebral microcirculation, Immunopharmacol 33, Seite 257-263. Walker, K.; Perkins, M. und Dray, A. (1995): Kinins and kinin receptors in the nervous system, Neurochem Int 26, Seite 1-16. Wolfe, L. S.; Pappius, H. M. und Marion, J. (1976): The biosynthesis of prostaglandins by brain tissue in vitro, Adv Prostaglandin and Throboxane Res 1, Seite 345-355. Wrba, E.; Nehring, V.; Baethmann, A.; Reulen, H. J. und Uhl, E. (1998): Resolution of experimental vasogenic brain edema at different intracranial pressures, Acta Neurochir Suppl. 71, Seite 313-315. Zweckenberger, K.; Stoffel, M.; Baethmann, A. und Plesnila, M. (2003): Effect of decompression craniotomy on increase of contusion volume and functional outcome after controlled cortical impact in mice, J Neurotrauma 20, Seite 1307-1314.