[Seite 93↓]


Abdurashidova, G., Deganuto, M., Klima, R., Riva, S., Biamonti, G., Giacca, M., and Falaschi, A. (2000). Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science 287, 2023-2026.

Achwal, C. W., Ganguly, P., and Chandra, H. S. (1984). Estimation of the amount of 5-methylcytosine in Drosophila melanogaster DNA by amplified ELISA and photoacoustic spectroscopy. EMBO J 3, 263-266.

Ahmad, K., and Henikoff, S. (2001). Centromeres are specialized replication domains in heterochromatin. J Cell Biol 153, 101-110.

Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990). Basic local alignment search tool. J Mol Biol 215, 403-410.

Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25, 3389-3402.

Bachman, K. E., Park, B. H., Rhee, I., Rajagopalan, H., Herman, J. G., Baylin, S. B., Kinzler, K. W., and Vogelstein, B. (2003). Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3, 89-95.

Bachman, K. E., Rountree, M. R., and Baylin, S. B. (2001). Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 276, 32282-32287.

Baker, T. A., and Bell, S. P. (1998). Polymerases and the replisome: machines within machines. Cell 92, 295-305.

Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., and Kouzarides, T. (2001 ). Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124.

Becker, P. B., Ruppert, S., and Schutz, G. (1987). Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell 51, 435-443.

Bell, S. P., Mitchell, J., Leber, J., Kobayashi, R., and Stillman, B. (1995). The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83, 563-568.

Berezney, R., Dubey, D. D., and Huberman, J. A. (2000). Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci. Chromosoma 108, 471-484.

Berezney, R., Mortillaro, M. J., Ma, H., Wei, X., and Samarabandu, J. (1995). The nuclear matrix: a structural milieu for genomic function. Int Rev Cytol, 1-65.

Berger, S. L. (2002). Histone modifications in transcriptional regulation. Curr Opin Genet Dev 12, 142-148.

Bestor, T., Laudano, A., Mattaliano, R., and Ingram, V. (1988). Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol 203, 971-983.

[Seite 94↓]

Bestor, T. H. (1992). Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J 11, 2611-2617.

Bestor, T. H. (2000). The DNA methyltransferases of mammals. Hum Mol Genet 9, 2395-2402.

Bestor, T. H., and Ingram, V. M. (1983). Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc Natl Acad Sci U S A 80, 5559-5563.

Bird, A. (2002). DNA methylation patterns and epigenetic memory. Genes Dev 16, 6-21.

Bird, A. P., Taggart, M. H., Nicholls, R. D., and Higgs, D. R. (1987). Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene . EMBO J 6, 999-1004.

Birnboim, H. C., and Doly, J. (1979). A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7, 1513-1523.

Blow, J. J. (2001). Control of chromosomal DNA replication in the early Xenopus embryo. EMBO J 20, 3293-3297.

Bonassi, S., and Au, W. W. (2002 ). Biomarkers in molecular epidemiology studies for health risk prediction . Mutat Res 511, 73-86.

Bourc'his, D., Xu, G. L., Lin, C. S., Bollman, B., and Bestor, T. H. (2001). Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539.

Bozhenok, L., Wade, P. A., and Varga-Weisz, P. (2002). WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J 21, 2231-2241.

Bravo, R., Frank, R., Blundell, P. A., and Macdonald-Bravo, H. (1987). Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 326, 515-517.

Bravo, R., and Macdonald-Bravo, H. (1987). Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105, 1549-1554.

Callebaut, I., Courvalin, J. C., and Mornon, J. P. (1999a). The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. FEBS Lett 446, 189-193.

Callebaut, I., Courvalin, J. C., and Mornon, J. P. (1999b). The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. FEBS Lett 446, 189-193.

Cardoso, M. C., Joseph, C., Rahn, H. P., Reusch, R., Nadal-Ginard, B., and Leonhardt, H. (1997). Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo. J Cell Biol 139, 579-587.

Cardoso, M. C., and Leonhardt, H. (1999a). „Differentiation, development and programmed cell death.“ in The Molecular Basis of Cell Cycle and Growth Control, G. Stein, R. Baserga, D. Denhardt, and A. Giordano, eds. (New York, John Wiley & Sons), pp. 305-347.

[Seite 95↓]

Cardoso, M. C., and Leonhardt, H. (1999b). DNA methyltransferase is actively retained in the cytoplasm during early development. J Cell Biol 147, 25-32.

Cardoso, M. C., Leonhardt, H., and Nadal-Ginard, B. (1993). Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74, 979-992.

Cardoso, M. C., Sporbert, A., and Leonhardt, H. (1999). Structure and function in the nucleus: subnuclear trafficking of DNA replication factors. J Cell Biochem Suppl, 15-23.

Carlson, L. L., Page, A. W., and Bestor, T. H. (1992). Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting . Genes Dev 6, 2536-2541.

Celis, J. E., and Celis, A. (1985). Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci U S A 82, 3262-3266.

Chen, T., Ueda, Y., Xie, S., and Li, E. (2002). A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation . J Biol Chem 277, 38746-38754.

Chuang, L. S., Ian, H. I., Koh, T. W., Ng, H. H., Xu, G., and Li, B. F. (1997). Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277, 1996-2000.

Chuang, L. S., Ng, H. H., Chia, J. N., and Li, B. F. (1996). Characterisation of independent DNA and multiple Zn-binding domains at the N terminus of human DNA-(cytosine-5) methyltransferase: modulating the property of a DNA-binding domain by contiguous Zn-binding motifs. J Mol Biol 257, 935-948.

Colot, V., and Rossignol, J. L. (1999 ). Eukaryotic DNA methylation as an evolutionary device. Bioessays 21, 402-411.

Cox, L. S., and Laskey, R. A. (1991). DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro. Cell 66, 271-275.

Czank, A., Hauselmann, R., Page, A. W., Leonhardt, H., Bestor, T. H., Schaffner, W., and Hergersberg, M. (1991). Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase. Gene 109, 259-263.

Dalrymple, B. P., Kongsuwan, K., Wijffels, G., Dixon, N. E., and Jennings, P. A. (2001). A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems. Proc Natl Acad Sci U S A 98, 11627-11632.

Davis, T., Kirk, D., Rinaldi, A., Burdon, R. H., and Adams, R. L. (1985). Delayed methylation and the matrix bound DNA methylase . Biochem Biophys Res Commun 126, 678-684.

DePamphilis, M. L. (1999 ). Replication origins in metazoan chromosomes: fact or fiction? Bioessays 21, 5-16.

Ehrlich, M. (2002). DNA methylation in cancer: too much, but also too little. Oncogene 21, 5400-5413.

Ehrlich, M., and Wang, R. Y. (1981). 5-Methylcytosine in eukaryotic DNA. Science 212, 1350-1357.

[Seite 96↓]

Foss, H. M., Roberts, C. J., Claeys, K. M., and Selker, E. U. (1993). Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation. Science 262, 1737-1741.

Fox, M. H., Arndt-Jovin, D. J., Jovin, T. M., Baumann, P. H., and Robert-Nicoud, M. (1991). Spatial and temporal distribution of DNA replication sites localized by immunofluorescence and confocal microscopy in mouse fibroblasts. J Cell Sci 99, 247-253.

Franceschini, P., Martino, S., Ciocchini, M., Ciuti, E., Vardeu, M. P., Guala, A., Signorile, F., Camerano, P., Franceschini, D., and Tovo, P. A. (1995). Variability of clinical and immunological phenotype in immunodeficiency-centromeric instability-facial anomalies syndrome. Report of two new patients and review of the literature. Eur J Pediatr 154, 840-846.

Fuks, F., Burgers, W. A., Brehm, A., Hughes-Davies, L., and Kouzarides, T. (2000). DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24, 88-91.

Fuss, J., and Linn, S. (2002). Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase. J Biol Chem 277, 8658-8666.

Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H., and Domann, F. E. (2002). Role for DNA methylation in the control of cell type specific maspin expression. Nat Genet 31, 175-179.

Gaudet, F., Talbot, D., Leonhardt, H., and Jaenisch, R. (1998). A short DNA methyltransferase isoform restores methylation in vivo. J Biol Chem 273 , 32725-32729.

Geraci, D., Eremenko, T., Cocchiara, R., Granieri, A., Scarano, E., and Volpe, P. (1974). Correlation between synthesis and methylation of DNA in HeLa cells . Biochem Biophys Res Commun 57, 353-358.

Giacca, M., Zentilin, L., Norio, P., Diviacco, S., Dimitrova, D., Contreas, G., Biamonti, G., Perini, G., Weighardt, F., Riva, S., and et al. (1994). Fine mapping of a replication origin of human DNA. Proc Natl Acad Sci U S A 91, 7119-7123.

Gilbert, D. M. (1998). Replication origins in yeast versus metazoa: separation of the haves and the have nots. Curr Opin Genet Dev 8, 194-199.

Glickman, J. F., Pavlovich, J. G., and Reich, N. O. (1997). Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation. J Biol Chem 272, 17851-17857.

Gluzman, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23, 175-182.

Goldman, M. A., Holmquist, G. P., Gray, M. C., Caston, L. A., and Nag, A. (1984). Replication timing of genes and middle repetitive sequences. Science 224, 686-692.

Gowher, H., Leismann, O., and Jeltsch, A. (2000). DNA of Drosophila melanogaster contains 5-methylcytosine. EMBO J 19, 6918-6923.

Goyon, C., Rossignol, J. L., and Faugeron, G. (1996 ). Native DNA repeats and methylation in Ascobolus. Nucleic Acids Res 24, 3348-3356.

[Seite 97↓]

Graham, F. L., and van der Eb, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.

Gribskov, M., McLachlan, A. D., and Eisenberg, D. (1987). Profile analysis: detection of distantly related proteins. Proc Natl Acad Sci U S A 84, 4355-4358.

Gruenbaum, Y., Cedar, H., and Razin, A. (1982). Substrate and sequence specificity of a eukaryotic DNA methylase. Nature 295, 620-622.

Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. (1996). Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87, 297-306.

Hata, K., Okano, M., Lei, H., and Li, E. (2002). Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129, 1983-1993.

Hatton, K. S., Dhar, V., Brown, E. H., Iqbal, M. A., Stuart, S., Didamo, V. T., and Schildkraut, C. L. (1988). Replication program of active and inactive multigene families in mammalian cells. Mol Cell Biol 8, 2149-2158.

Heard, E., Rougeulle, C., Arnaud, D., Avner, P., Allis, C. D., and Spector, D. L. (2001). Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell 107, 727-738.

Hein, J. (1990 ). Unified approach to alignment and phylogenies. Methods Enzymol 183, 626-645.

Holliday, R., and Pugh, J. E. (1975 ). DNA modification mechanisms and gene activity during development. Science 187, 226-232.

Hozak, P., Hassan, A. B., Jackson, D. A., and Cook, P. R. (1993). Visualization of replication factories attached to nucleoskeleton. Cell 73, 361-373.

Issa, J. P., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., and Baylin, S. B. (1994). Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7, 536-540.

Jackson, D. A., and Cook, P. R. (1986). Replication occurs at a nucleoskeleton. EMBO J 5, 1403-1410.

Jackson, D. A., and Pombo, A. (1998). Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J Cell Biol 140, 1285-1295.

Jacob, F., Brenner, S., and Cuzin, F. (1964). On the regulation of DNA replication in bacteria. Cold Spring Harbor Sump Quant Biol 28, 329-345.

Jeanpierre, M., Turleau, C., Aurias, A., Prieur, M., Ledeist, F., Fischer, A., and Viegas-Pequignot, E. (1993). An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome. Hum Mol Genet 2, 731-735.

Jones, P. A., and Taylor, S. M. (1980). Cellular differentiation, cytidine analogs and DNA methylation. Cell 20, 85-93.

Jost, J. P., and Jost, Y. C. (1994). Transient DNA demethylation in differentiating mouse myoblasts correlates with higher activity of 5-methyldeoxycytidine excision repair. J Biol Chem 269, 10040-10043.

[Seite 98↓]

Kannouche, P., Broughton, B. C., Volker, M., Hanaoka, F., Mullenders, L. H., and Lehmann, A. R. (2001). Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev 15, 158-172.

Kouzminova, E., and Selker, E. U. (2001). dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora. EMBO J 20, 4309-4323.

Kress, C., Thomassin, H., and Grange, T. (2001). Local DNA demethylation in vertebrates: how could it be performed and targeted? FEBS Lett 494, 135-140.

Krishna, T. S., Kong, X. P., Gary, S., Burgers, P. M., and Kuriyan, J. (1994). Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell 79 , 1233-1243.

Lachner, M., and Jenuwein, T. (2002). The many faces of histone lysine methylation. Curr Opin Cell Biol 14, 286-298.

Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001). Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120.

Lei, H., Oh, S. P., Okano, M., Juttermann, R., Goss, K. A., Jaenisch, R., and Li, E. (1996). De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122, 3195-3205.

Leipe, D. D., Aravind, L., and Koonin, E. V. (1999). Did DNA replication evolve twice independently? Nucleic Acids Res 27, 3389-3401.

Leonhardt, H., and Cardoso, M. C. (1995). Targeting and association of proteins with functional domains in the nucleus: the insoluble solution. Int Rev Cytol 162B, 303-335.

Leonhardt, H., and Cardoso, M. C. (2000). DNA methylation, nuclear structure, gene expression and cancer . J Cell Biochem Suppl, 78-83.

Leonhardt, H., Page, A. W., Weier, H. U., and Bestor, T. H. (1992). A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865-873.

Leonhardt, H., Rahn, H. P., and Cardoso, M. C. (1998 ). Intranuclear targeting of DNA replication factors. J Cell Biochem Suppl 31, 243-249.

Leonhardt, H., Rahn, H. P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D., and Cardoso, M. C. (2000a). Dynamics of DNA replication factories in living cells. J Cell Biol 149, 271-280.

Leonhardt, H., Sporbert, A., and Cardoso, M. C. (2000b). Targeting regulatory factors to intranuclear replication sites. Crit Rev Eukaryot Gene Expr 10, 127-133.

Li, E., Beard, C., and Jaenisch, R. (1993). Role for DNA methylation in genomic imprinting. Nature 366, 362-365.

Li, E., Bestor, T. H., and Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926.

[Seite 99↓]

Litt, M. D., Simpson, M., Gaszner, M., Allis, C. D., and Felsenfeld, G. (2001). Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 293, 2453-2455.

Liu, Y., Oakeley, E. J., Sun, L., and Jost, J. P. (1998). Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci. Nucleic Acids Res 26, 1038-1045.

Lock, L. F., Takagi, N., and Martin, G. R. (1987). Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell 48, 39-46.

Lyko, F., Whittaker, A. J., Orr-Weaver, T. L., and Jaenisch, R. (2000). The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries. Mech Dev 95, 215-217.

Ma, H., Samarabandu, J., Devdhar, R. S., Acharya, R., Cheng, P. C., Meng, C., and Berezney, R. (1998). Spatial and temporal dynamics of DNA replication sites in mammalian cells. J Cell Biol 143, 1415-1425.

Margot, J. B., Aguirre-Arteta, A. M., Di Giacco, B. V., Pradhan, S., Roberts, R. J., Cardoso, M. C., and Leonhardt, H. (2000). Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure. J Mol Biol 297, 293-300.

Margot, J. B., Cardoso, M. C., and Leonhardt, H. (2001). Mammalian DNA methyltransferases show different subnuclear distributions. J Cell Biochem 83, 373-379.

Martienssen, R. A., and Colot, V. (2001). DNA methylation and epigenetic inheritance in plants and filamentous fungi. Science 293, 1070-1074.

Matthias, P., Müller, M. M., Schreiber, E., Rusconi, S., and Schaffner, W. (1989). Eukaryotic expression vectors for the analysis of mutant proteins. Nucl Acids Res 17, 6418.

Mattock, H., Lane, D. P., and Warbrick, E. (2001). Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein. Exp Cell Res 265, 234-241.

Mayer, W., Niveleau, A., Walter, J., Fundele, R., and Haaf, T. (2000). Demethylation of the zygotic paternal genome. Nature 403, 501-502.

Monk, M., Boubelik, M., and Lehnert, S. (1987). Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382.

Montecucco, A., Rossi, R., Levin, D. S., Gary, R., Park, M. S., Motycka, T. A., Ciarrocchi, G., Villa, A., Biamonti, G., and Tomkinson, A. E. (1998). DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J 17, 3786-3795.

Montecucco, A., Savini, E., Weighardt, F., Rossi, R., Ciarrocchi, G., Villa, A., and Biamonti, G. (1995). The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication . EMBO J 14, 5379-5386.

[Seite 100↓]

Nakamura, H., Morita, T., and Sato, C. (1986). Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res 165, 291-297.

Nakayasu, H., and Berezney, R. (1989). Mapping replicational sites in the eucaryotic cell nucleus. J Cell Biol 108, 1-11.

Newlon, C. S., and Theis, J. F. (1993). The structure and function of yeast ARS elements. Curr Opin Genet Dev 3, 752-758.

Nishioka, K., Chuikov, S., Sarma, K., Erdjument-Bromage, H., Allis, C. D., Tempst, P., and Reinberg, D. (2002). Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev 16, 479-489.

Noma, K., Allis, C. D., and Grewal, S. I. (2001). Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293, 1150-1155.

O'Keefe, R. T., Henderson, S. C., and Spector, D. L. (1992). Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. J Cell Biol 116, 1095-1110.

Okano, M., Bell, D. W., Haber, D. A., and Li, E. (1999). DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257.

Okano, M., Xie, S., and Li, E. (1998a). Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19, 219-220.

Okano, M., Xie, S., and Li, E. (1998b). Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res 26, 2536-2540.

Ono, T., Takahashi, N., and Okada, S. (1989). Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice. Mutat Res 219, 39-50.

Oswald, J., Engemann, S., Lane, N., Mayer, W., Olek, A., Fundele, R., Dean, W., Reik, W., and Walter, J. (2000). Active demethylation of the paternal genome in the mouse zygote. Curr Biol 10, 475-478.

Otterlei, M., Warbrick, E., Nagelhus, T. A., Haug, T., Slupphaug, G., Akbari, M., Aas, P. A., Steinsbekk, K., Bakke, O., and Krokan, H. E. (1999). Post-replicative base excision repair in replication foci. EMBO J 18, 3834-3844.

Parker, B. A., and Stark, G. R. (1979). Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA. J Virol 31, 360-369.

Pinarbasi, E., Elliott, J., and Hornby, D. P. (1996). Activation of a yeast pseudo DNA methyltransferase by deletion of a single amino acid. J Mol Biol 257, 804-813.

Pradhan, S., Bacolla, A., Wells, R. D., and Roberts, R. J. (1999). Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation . J Biol Chem 274, 33002-33010.

[Seite 101↓]

Prelich, G., Tan, C. K., Kostura, M., Mathews, M. B., So, A. G., Downey, K. M., and Stillman, B. (1987). Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 326, 517-520.

Rabinowicz, P. D., Schutz, K., Dedhia, N., Yordan, C., Parnell, L. D., Stein, L., McCombie, W. R., and Martienssen, R. A. (1999). Differential methylation of genes and retrotransposons facilitates shotgun sequencing of the maize genome. Nat Genet 23, 305-308.

Razin, A., Szyf, M., Kafri, T., Roll, M., Giloh, H., Scarpa, S., Carotti, D., and Cantoni, G. L. (1986). Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation. Proc Natl Acad Sci U S A 83, 2827-2831.

Reik, W., Dean, W., and Walter, J. (2001). Epigenetic reprogramming in mammalian development. Science 293, 1089-1093.

Riggs, A. D. (1975). X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 14, 9-25.

Roberts, D. B. (1998). Drosophila, A Practical Approach (Second Edition). Oxford University Press.

Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., and Wolffe, A. P. (2000). DNMT1 forms a complex with rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25, 338-342.

Robertson, K. D., and Wolffe, A. P. (2000). DNA methylation in health and disease. Nat Rev Genet 1, 11-19.

Rougier, N., Bourc'his, D., Gomes, D. M., Niveleau, A., Plachot, M., Paldi, A., and Viegas-Pequignot, E. (1998). Chromosome methylation patterns during mammalian preimplantation development. Genes Dev 12, 2108-2113.

Rountree, M. R., Bachman, K. E., and Baylin, S. B. (2000). DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 25, 269-277.

Sadoni, N., Langer, S., Fauth, C., Bernardi, G., Cremer, T., Turner, B. M., and Zink, D. (1999). Nuclear organization of mammalian genomes. Polar chromosome territories build up functionally distinct higher order compartments. J Cell Biol 146, 1211-1226.

Samaniego, R., de la Torre, C., and Moreno Diaz de la Espina, S. (2002). Dynamics of replication foci and nuclear matrix during S phase in Allium cepa L. cells. Planta 215, 195-204.

Sambrook, J., and Russell, D. W. (2001). Molecular Cloning, A Laboratory Manual (Third Edition). Cold Spring Harbor Laboratory Press.

Schneider, I. (1972). Cell lines derived from late embryonic stages of Drosophila melanogaster. J Embryol Exp Morphol 27, 353-365.

Simmen, M. W., Leitgeb, S., Charlton, J., Jones, S. J., Harris, B. R., Clark, V. H., and Bird, A. (1999). Nonmethylated transposable elements and methylated genes in a chordate genome. Science 283, 1164-1167.

[Seite 102↓]

Smith, J. G., and Calos, M. P. (1995 ). Autonomous replication in Drosophila melanogaster tissue culture cells. Chromosoma 103, 597-605.

Somanathan, S., Suchyna, T. M., Siegel, A. J., and Berezney, R. (2001). Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus. J Cell Biochem 81, 56-67.

Sparvoli, E., Levi, M., and Rossi, E. (1994). Replicon clusters may form structurally stable complexes of chromatin and chromosomes. J Cell Sci 107, 3097-3103.

Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H., and Cardoso, M. C. (2002). DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters. Mol Cell 10, 1355-1365.

Stewart, C. L., Stuhlmann, H., Jahner, D., and Jaenisch, R. (1982). De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci U S A 79, 4098-4102.

Stinchcomb, D. T., Struhl, K., and Davis, R. W. (1979). Isolation and characterisation of a yeast chromosomal replicator. Nature 282, 39-43.

Strahl, B. D., and Allis, C. D. (2000). The language of covalent histone modifications. Nature 403, 41-45.

Suetake, L., Shi, L., Watanabe, D., Nakamura, M., and Tajima, S. (2001). Proliferation stage-dependent expression of DNA methyltransferase (Dnmt1) in mouse small intestine. Cell Struct Funct 26, 79-86.

Tate, P. H., and Bird, A. P. (1993). Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 3, 226-231.

Ten Hagen, K. G., Gilbert, D. M., Willard, H. F., and Cohen, S. N. (1990). Replication timing of DNA sequences associated with human centromeres and telomeres. Mol Cell Biol 10, 6348-6355.

Toth, M., Muller, U., and Doerfler, W. (1990). Establishment of de novo DNA methylation patterns. Transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter. J Mol Biol 214, 673-683.

Tucker, J. D., and Preston, R. J. (1996). Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat Res 365, 147-159.

Tweedie, S., Ng, H. H., Barlow, A. L., Turner, B. M., Hendrich, B., and Bird, A. (1999). Vestiges of a DNA methylation system in Drosophila melanogaster? Nat Genet 23, 389-390.

Varga-Weisz, P. D., and Dalgaard, J. Z. (2002). A mark in the core: silence no more! Mol Cell 9, 1154-1156.

Warbrick, E., Heatherington, W., Lane, D. P., and Glover, D. M. (1998). PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain. Nucleic Acids Res 26, 3925-3932.

Wigler, M., Levy, D., and Perucho, M. (1981). The somatic replication of DNA methylation. Cell 24, 33-40.

[Seite 103↓]

Wilkinson, C. R., Bartlett, R., Nurse, P., and Bird, A. P. (1995). The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue. Nucleic Acids Res 23, 203-210.

Wilks, A., Seldran, M., and Jost, J. P. (1984). An estrogen-dependent demethylation at the 5' end of the chicken vitellogenin gene is independent of DNA synthesis. Nucleic Acids Res 12, 1163-1177.

Woodcock, D. M., Adams, J. K., and Cooper, I. A. (1982). Characteristics of enzymatic DNA methylation in cultured cells of human and hamster origin, and the effect of DNA replication inhibition. Biochim Biophys Acta 696, 15-22.

Wu, C., and Morris, J. R. (2001). Genes, genetics, and epigenetics: a correspondence. Science 293, 1103-1105.

Wu, J. C., and Santi, D. V. (1987). Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem 262, 4778-4786.

Xu, G. L., Bestor, T. H., Bourc'his, D., Hsieh, C. L., Tommerup, N., Bugge, M., Hulten, M., Qu, X., Russo, J. J., and Viegas-Pequignot, E. (1999). Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402, 187-191.

Yaffe, D., and Saxel, O. (1977). Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 270, 725-727.

Yoder, J. A., Soman, N. S., Verdine, G. L., and Bestor, T. H. (1997a). DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J Mol Biol 270, 385-395.

Yoder, J. A., Walsh, C. P., and Bestor, T. H. (1997b). Cytosine methylation and the ecology of intragenomic parasites . Trends Genet 13, 335-340.

Zhang, Z., Hayashi, M. K., Merkel, O., Stillman, B., and Xu, R. M. (2002). Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing . EMBO J 21, 4600-4611.

Zhang, Z., Shibahara, K., and Stillman, B. (2000). PCNA connects DNA replication to epigenetic inheritance in yeast. Nature 408, 221-225.

Zheleva, D. I., Zhelev, N. Z., Fischer, P. M., Duff, S. V., Warbrick, E., Blake, D. G., and Lane, D. P. (2000). A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics. Biochemistry 39, 7388-7397.

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