<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">In <em>vivo-</em> und in <em>vitro-</em>Komplementaktivierung durch den monoklonalen CD20-Antikörper Rituximab bei der Behandlung von  Non-Hodgkin-Lymphomen</cms:entry><cms:entry type="author">Christian Gerecke</cms:entry><cms:entry id="N10045" part="front" ref="N10045" type="dedication">I</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1.</cms:entry><cms:entry id="N1005A" part="chapter1" ref="N1005A" type="section">1.1</cms:entry><cms:entry id="N10061" part="chapter1" ref="N10061" type="citenumber">1</cms:entry><cms:entry id="N1006D" part="chapter1" ref="N1006D" type="citenumber">2</cms:entry><cms:entry id="N10072" part="chapter1" ref="N10072" type="section">1.2</cms:entry><cms:entry id="N1007F" part="chapter1" ref="N1007F" type="citenumber">3</cms:entry><cms:entry id="N1008B" part="chapter1" ref="N1008B" type="citenumber">4</cms:entry><cms:entry id="N10090" part="chapter1" ref="N10090" type="section">1.3</cms:entry><cms:entry id="N1009D" part="chapter1" ref="N1009D" type="citenumber">5</cms:entry><cms:entry id="N100A9" part="chapter1" ref="N100A9" type="citenumber">6</cms:entry><cms:entry id="N100AE" part="chapter1" ref="N100AE" type="section">1.4</cms:entry><cms:entry id="N100BB" part="chapter1" ref="N100BB" type="citenumber">7</cms:entry><cms:entry id="N100C3" part="chapter1" ref="N100C3" type="section">1.5</cms:entry><cms:entry id="N100CD" part="chapter1" ref="N100CD" type="citenumber">8</cms:entry><cms:entry id="N100D0" part="chapter1" ref="N100D0" type="mm">548#282</cms:entry><cms:entry id="N1011F" part="chapter1" ref="N1011F" type="section">1.6</cms:entry><cms:entry id="N10126" part="chapter1" ref="N10126" type="citenumber">9</cms:entry><cms:entry id="N10138" part="chapter1" ref="N10138" type="citenumber">10</cms:entry><cms:entry id="N1014A" part="chapter1" ref="N1014A" type="citenumber">11</cms:entry><cms:entry id="N1015B" part="chapter1" ref="N1015B" type="section">1.7</cms:entry><cms:entry id="N10162" part="chapter1" ref="N10162" type="citenumber">12</cms:entry><cms:entry id="N1016E" part="chapter1" ref="N1016E" type="citenumber">13</cms:entry><cms:entry id="N10179" part="chapter1" ref="N10179" type="section">1.8</cms:entry><cms:entry id="N10183" part="chapter1" ref="N10183" type="mm">548#282</cms:entry><cms:entry id="N1018E" part="chapter1" ref="N1018E" type="citenumber">14</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2.</cms:entry><cms:entry id="N101C1" part="chapter2" ref="N101C1" type="section">2.1</cms:entry><cms:entry id="N101C6" part="chapter2" ref="N101C6" type="helpercitenumber">14</cms:entry><cms:entry id="N101C8" part="chapter2" ref="N101C8" type="table"/><cms:entry id="N10327" part="chapter2" ref="N10327" type="section">2.2</cms:entry><cms:entry id="N1032E" part="chapter2" ref="N1032E" type="citenumber">15</cms:entry><cms:entry id="N10331" part="chapter2" ref="N10331" type="table"/><cms:entry id="N104A8" part="chapter2" ref="N104A8" type="section">2.3</cms:entry><cms:entry id="N104B5" part="chapter2" ref="N104B5" type="citenumber">16</cms:entry><cms:entry id="N104C7" part="chapter2" ref="N104C7" type="citenumber">17</cms:entry><cms:entry id="N104CD" part="chapter2" ref="N104CD" type="table"/><cms:entry id="N104EB" part="chapter2" ref="N104EB" type="mm">783#545</cms:entry><cms:entry id="N104F7" part="chapter2" ref="N104F7" type="section">2.4</cms:entry><cms:entry id="N10504" part="chapter2" ref="N10504" type="citenumber">18</cms:entry><cms:entry id="N10517" part="chapter2" ref="N10517" type="citenumber">19</cms:entry><cms:entry id="N1052A" part="chapter2" ref="N1052A" type="citenumber">20</cms:entry><cms:entry id="N1053E" part="chapter2" ref="N1053E" type="section">2.5</cms:entry><cms:entry id="N1054A" part="chapter2" ref="N1054A" type="section">2.6</cms:entry><cms:entry id="N10554" part="chapter2" ref="N10554" type="citenumber">21</cms:entry><cms:entry id="N1055F" part="chapter2" ref="N1055F" type="section">2.7</cms:entry><cms:entry id="N10569" part="chapter2" ref="N10569" type="citenumber">22</cms:entry><cms:entry id="N1057B" part="chapter2" ref="N1057B" type="citenumber">23</cms:entry><cms:entry id="N10580" part="chapter2" ref="N10580" type="section">2.8</cms:entry><cms:entry id="N1058D" part="chapter2" ref="N1058D" type="citenumber">24</cms:entry><cms:entry id="N10599" part="chapter2" ref="N10599" type="citenumber">25</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3.</cms:entry><cms:entry id="N105B0" part="chapter3" ref="N105B0" type="section">3.1</cms:entry><cms:entry id="N105B7" part="chapter3" ref="N105B7" type="citenumber">26</cms:entry><cms:entry id="N105BD" part="chapter3" ref="N105BD" type="mm">399#436</cms:entry><cms:entry id="N105CE" part="chapter3" ref="N105CE" type="citenumber">27</cms:entry><cms:entry id="N105D1" part="chapter3" ref="N105D1" type="mm">399#436</cms:entry><cms:entry id="N105E5" part="chapter3" ref="N105E5" type="citenumber">28</cms:entry><cms:entry id="N105E8" part="chapter3" ref="N105E8" type="mm">451#447</cms:entry><cms:entry id="N105F9" part="chapter3" ref="N105F9" type="mm">440#439</cms:entry><cms:entry id="N10609" part="chapter3" ref="N10609" type="citenumber">29</cms:entry><cms:entry id="N1060F" part="chapter3" ref="N1060F" type="mm">467#447</cms:entry><cms:entry id="N10620" part="chapter3" ref="N10620" type="citenumber">30</cms:entry><cms:entry id="N10626" part="chapter3" ref="N10626" type="mm">437#440</cms:entry><cms:entry id="N10639" part="chapter3" ref="N10639" type="citenumber">31</cms:entry><cms:entry id="N1063C" part="chapter3" ref="N1063C" type="mm">355#372</cms:entry><cms:entry id="N10649" part="chapter3" ref="N10649" type="section">3.2</cms:entry><cms:entry id="N10656" part="chapter3" ref="N10656" type="citenumber">32</cms:entry><cms:entry id="N10659" part="chapter3" ref="N10659" type="mm">588#468</cms:entry><cms:entry id="N1066D" part="chapter3" ref="N1066D" type="mm">574#458</cms:entry><cms:entry id="N1067E" part="chapter3" ref="N1067E" type="citenumber">33</cms:entry><cms:entry id="N10684" part="chapter3" ref="N10684" type="mm">566#497</cms:entry><cms:entry id="N10698" part="chapter3" ref="N10698" type="citenumber">34</cms:entry><cms:entry id="N1069B" part="chapter3" ref="N1069B" type="mm">592#487</cms:entry><cms:entry id="N106AB" part="chapter3" ref="N106AB" type="section">3.3</cms:entry><cms:entry id="N106BB" part="chapter3" ref="N106BB" type="citenumber">35</cms:entry><cms:entry id="N106C1" part="chapter3" ref="N106C1" type="table"/><cms:entry id="N10745" part="chapter3" ref="N10745" type="table"/><cms:entry id="N1082C" part="chapter3" ref="N1082C" type="citenumber">36</cms:entry><cms:entry id="N1082F" part="chapter3" ref="N1082F" type="table"/><cms:entry id="N108B0" part="chapter3" ref="N108B0" type="citenumber">37</cms:entry><cms:entry id="N108B3" part="chapter3" ref="N108B3" type="mm">451#396</cms:entry><cms:entry id="N108C6" part="chapter3" ref="N108C6" type="mm">510#422</cms:entry><cms:entry id="N108D1" part="chapter3" ref="N108D1" type="citenumber">38</cms:entry><cms:entry id="N108D7" part="chapter3" ref="N108D7" type="mm">480#430</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4.</cms:entry><cms:entry id="N108EA" part="chapter4" ref="N108EA" type="section">4.1</cms:entry><cms:entry id="N108F1" part="chapter4" ref="N108F1" type="helpercitenumber">38</cms:entry><cms:entry id="N108F6" part="chapter4" ref="N108F6" type="citenumber">39</cms:entry><cms:entry id="N10905" part="chapter4" ref="N10905" type="citenumber">40</cms:entry><cms:entry id="N10911" part="chapter4" ref="N10911" type="citenumber">41</cms:entry><cms:entry id="N10920" part="chapter4" ref="N10920" type="citenumber">42</cms:entry><cms:entry id="N10931" part="chapter4" ref="N10931" type="section">4.2</cms:entry><cms:entry id="N10938" part="chapter4" ref="N10938" type="citenumber">43</cms:entry><cms:entry id="N10944" part="chapter4" ref="N10944" type="citenumber">44</cms:entry><cms:entry id="N10956" part="chapter4" ref="N10956" type="citenumber">45</cms:entry><cms:entry id="N10965" part="chapter4" ref="N10965" type="citenumber">46</cms:entry><cms:entry id="N1096A" part="chapter4" ref="N1096A" type="section">4.3</cms:entry><cms:entry id="N1097D" part="chapter4" ref="N1097D" type="citenumber">47</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5.</cms:entry><cms:entry id="N10996" part="chapter5" ref="N10996" type="citenumber">48</cms:entry><cms:entry id="N109A8" part="chapter5" ref="N109A8" type="citenumber">49</cms:entry><cms:entry id="N109B4" part="chapter5" ref="N109B4" type="citenumber">50</cms:entry><cms:entry id="N109C3" part="chapter5" ref="N109C3" type="citenumber">51</cms:entry><cms:entry id="N109D2" part="chapter5" ref="N109D2" type="citenumber">52</cms:entry><cms:entry ref="N109D8" type="back"/><cms:entry id="N109DA" part="N109DA" ref="N109DA" type="abbreviation">6. Abkürzungsverzeichnis</cms:entry><cms:entry id="N109E1" part="N109DA" ref="N109E1" type="table"/><cms:entry ref="N10CE4" type="bibliography">7.  Literaturverzeichnis  </cms:entry><cms:entry id="N11755" part="N11755" ref="N11755" type="declaration">Eidesstattliche Erklärung</cms:entry><cms:entry id="N11764" part="N11764" ref="N11764" type="acknowledgement">     Danksagung</cms:entry><cms:entry part="N10CE4" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N10CE4">
         <head>7.  Literaturverzeichnis  </head>
         <p>
            <strong>7.1 Bücher</strong>
         </p>
         
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               <workauthor>1.  Fauci A.S., Braunwald E., Isselbacher K.J., Wilson J.D., Martin J.B., Kasper D.L., Hauser S.L., Longo D.L.</workauthor>
               <pubdate>(1999):</pubdate> Harrisons Innere Medizin. <version>14. Auflage</version>
               <publisher>McGraw-Hill</publisher>
               <publisher>Internatinal (UK) Ltd.</publisher>
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               <workauthor>2. Fuchs R.</workauthor>
               <pubdate>(1997):</pubdate> Diagnostik und Therapie lymphatischer Neoplasien.</citation>
         
         
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               <workauthor>3. Bortz J., Lienert G.A.</workauthor>
               <pubdate>(1998):</pubdate> Kurzgefasste Statistik für die klinische Forschung. <address>Heidelberg:</address>
               <publisher>Springer</publisher>
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            <citation published="yes" workType="Book">
               <workauthor>4. Janeway C.A., Travers P., Walport M., Capra J.D.</workauthor> (<pubdate>1999</pubdate>): Immunobiologie. <version>4.</version>
               <version>Auflage</version>, <address>New York</address>
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            <citation published="yes" workType="Book">
               <workauthor>5. Schmoll H.-J., Höffken K., Possinger K.</workauthor> (<pubdate>1999</pubdate>): Kompendium Internistische Onkologie <version>3. Auflage,</version>
               <publisher>Springer Verlag</publisher>
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            <citation published="yes" workType="Book">
               <workauthor>6. Paumgartner G.:</workauthor> Therapie innerer Krankheiten. <version>9. Auflage</version>, <publisher>Springer Verlag</publisher>
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         <p>
            <strong>7.2 Zeitschriften</strong>
         </p>
         
            <citation published="yes" workType="Journal">
               <workauthor>7. Devesa S.S., Fears T</workauthor>
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               <articletitle>Non-Hodgkin`s Lymphoma Time Trends: United States and International Data.</articletitle> Cancer Research <volume>52</volume>
               <number>(Suppl.19):</number>
               <pages>5432-5440</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>8. Devesa S.S., Blot W.J., Stone B.J., Miller B.A., Tarone R.E., Fraumeni F., Jr.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Resent Cancer Trends in the United States</articletitle>. Journal National Cancer Institut <volume>87</volume>: <pages>175-182</pages>
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               <workauthor>9. Hardell L., Ericsson M.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>A case- control study of non-Hodgkin lym</articletitle>
               <articletitle>phoma and exposure to pesticides.</articletitle> Cancer <volume>85</volume>
               <number>(6):</number>
               <pages>1353-1360</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>10. Khorana A.A., Rosenblatt J.D., Young F.M.</workauthor>
               <pubdate>(2001):</pubdate>
               <articletitle>Immunopathogenesis of HIV and HTLV-1 infection: mechanisms for lymphomagenesis.</articletitle> Cancer Treatment Research <volume>104:</volume>
               <pages>19-74</pages>
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               <workauthor>11. Du M.Q., Diss T.C., Liu H. et al.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>KSHV- and EBV-associated germinotropic lymphoproliferative disorder.</articletitle> Blood <volume>100</volume>
               <number>(9)</number>:<pages>3415-3418</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>12. Le Beau M.M.</workauthor>
               <pubdate>(1990)</pubdate>
               <articletitle>Chromosomal abnormalities in non-Hodgkin&#8217;s lymphomas.</articletitle> Seminars in Oncology <volume>17</volume>: <pages>20-29</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>13. Gerhard-Marchant R., Hamlin I., Lennert K., Rilke F., Stansfeld A., van Unnik J</workauthor>
               <pubdate>.(1974)</pubdate>
               <articletitle>Classification of non-Hodgkin lymphomas.</articletitle> Lancet <volume>2</volume>: <pages>406-408</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>14. Stansfeld A., Diebold J., Kapanci Y., et al.</workauthor>
               <pubdate>(1988)</pubdate>
               <articletitle>Updated Kiel classification for lymphomas.</articletitle> Lancet <volume>1:</volume>
               <pages>292-293</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>15. Lennert K., Feller A.</workauthor>
               <pubdate>(1992)</pubdate>
               <articletitle>Histopathology of Non-Hodgkin&#8217;s Lymphomas.</articletitle>
               <publisher>New York: Springer Verlag</publisher>
            </citation>
         
         
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               <workauthor>16. Rappaport H.</workauthor>
               <pubdate>(1966)</pubdate>
               <articletitle>Atlas of tumor pathology</articletitle>, <volume>section III, fascicle 8.</volume>
               <address>Armed Forces Institute of Pathology.</address>
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            <citation published="yes" workType="Journal">
               <articletitle>17. The Non-Hodgkin&#8217;s Lymphoma Classification Project: National Cancer Insti</articletitle>
               <articletitle>tute sponsored study of classification of Non-Hodgkin&#8217;s lymphomas: summary and description of a Working Formulation for clinical usage.</articletitle>
               <pubdate>(1982)</pubdate> Cancer <volume>49</volume>: <pages>2112-2135</pages>
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               <workauthor>18. Harris N.L., Jaffe E.S., Stein H. et al.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>A revised European-American classification of lymphoid neoplasms: a proposal from the International Lym</articletitle>
               <articletitle>phoma Study Group.</articletitle>
               <pubdate>(1994)</pubdate> Blood <volume>84:</volume>
               <pages>1361-1392</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>19. Jaffe E.S., Harris N.L., Diebold J., Müller-Hermelink H.K.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>World Health Organisation Classification of lymphomas: A work in progress.</articletitle> Annals of Oncology <volume>9</volume>
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            <citation published="yes" workType="Journal">
               <workauthor>20. Stein H., Hiddemann W.</workauthor>
               <pubdate>(1999)</pubdate>
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               <pages>A3168-3176</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>21. Carbone P.P., Kaplan H.S., Musshoff K., Smithers D.W., Tubina M.</workauthor>
               <pubdate>(1971)</pubdate>
               <articletitle>Report of the committee on Hodgkin&#8217;s disease staging classification.</articletitle> Cancer Research <volume>31:</volume>
               <pages>1860-1861</pages>
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            <citation published="yes" workType="Journal">
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               <pubdate>(1997)</pubdate>
               <articletitle>Extended field and total central lymphatic radiotherapy in the treatment of early stage lymph node centroblastic-centro</articletitle>
               <articletitle>cytic lymphomas: results of a prospective multicenter study.</articletitle> Cancer <volume>80</volume>: <pages>2273-2284</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>23. MacManus M.P., Hoppe R.T.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>Is radiotherapy curative for stage I or II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University.</articletitle> Journal of Clinical Oncology <volume>14</volume>: <pages>1282-1290</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>24. Vaughan-Hudson B., Vaughan-Hudson G., MacLennan K.A.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Clinical stage I non-Hodgkin&#8217;s lymphoma: Long-term follow-up of patients treated by the British National Lymphoma Investigation with radiotherapy alone as initial therapy.</articletitle> British Journal of Cancer <volume>69</volume>: <pages>1088-1093</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>25. Hiddemann W., Dreyling M., Unterhalt M.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Aktuelle Entwicklungen in der Therapie follikulärer Keimzentrumslymphome.</articletitle> Der Onkologe <volume>7</volume>: <pages>969-981</pages>
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               <workauthor>26. Biermann P., Vose J.M., Anderson J.R., Bishop M.R. Kessinger A., Armitage J.O.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>High-dose therapy with autologous hematopoietic rescue for follicular low-grade non-Hodgkin&#8217;s lymphoma.</articletitle> Journal of clinical Oncology <volume>15</volume>: <pages>445-450</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>27. Coiffier B., Lepage E., Brière J. et al.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>CHOP-Chemotherapie plus Rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.</articletitle> New England Journal of Medicine <volume>346</volume>: <pages>235-242</pages>
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               <workauthor>28. Pfreundschuh M., Truemper L., Schmits R.</workauthor>
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               <articletitle>2-weekly vs. 3-weekly CHOP with and without Etoposide in Young Patients with Low-Risk (low LDH) Aggressive Non-Hodgkin's Lymphoma: Results of the Completed NHL-B-1 Trial of the DSHNHL.</articletitle>
               <address>ASH 2002</address>; <pages>Abstract #340</pages>
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               <workauthor>29. Wunderlich A., Kloess M., Reiser M. et al.</workauthor>
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               <workauthor>30. Köhler G., Milstein C.</workauthor>, <pubdate>(1975)</pubdate>
               <articletitle>Continuous cultures of fused cells secreting anti</articletitle>
               <articletitle>body of pre-defined specificity</articletitle>. Nature <volume>256:</volume>
               <pages>652-661</pages>
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               <workauthor>31. Press O.W., Appelbaum F., Ledbetter J.A. et al.</workauthor>
               <pubdate>(1987)</pubdate>
               <articletitle>Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas.</articletitle> Blood <volume>69</volume>
               <number>(2)</number>: <pages>584-591</pages>
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               <workauthor>32. Foon K.A.</workauthor>
               <pubdate>(2000)</pubdate>
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               <workauthor>33. Coiffier B.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Monoclonal antibodies in the treatment of non-Hodgkin&#8217;s lymphoma.</articletitle> Haematologica <volume>84</volume>
               <pages>(14-18)</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>34. Quesada J.R., Reuben J., Manning J.T., Hersh E.M., Gutterman J.U.</workauthor>
               <pubdate>(1984)</pubdate>
               <articletitle>Alpha interferon for induction of remission in hairy cell leukaemia.</articletitle> New England Journal of Medicine <volume>310:</volume>
               <pages> 15-28</pages>
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            <citation published="yes" workType="Journal">
               <workauthor>35. Golomb H.M., Jacobs A., Fefer A. et al.</workauthor>
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