Endotheliale Stickstoffmonoxidsynthase-vermittelte Effekte von HMG-CoA-Reduktase-Inhibitoren und körperlicher Aktivität im experimentellen SchlaganfallmodellKaren Gertz112454#340324356748910511121314467#34815Abkürzungsverzeichnis Literaturverzeichnis1617181920 Verwendete Publikationen21 Selbständigkeitserklärung2223Danksagung Eidesstattliche Erklärung24 Lebenslauf und Publikationsliste25 Publikationen (kumulativer Impactfaktor, Stand 2003: 48,3)2627deInhaltsverzeichnisHilfe Publikationen (kumulativer Impactfaktor, Stand 2003: 48,3)

Katchanov J, Waeber C, Gertz K, Gietz A, Winter B, Bruck W, Dirnagl U, Veh RW, Endres M (2003) Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain Pathol 13 (4): 452-464[3,8]

Endres M, Gertz K, Lindauer U, Katchanov J, Schultze J, Schrock H, Nickenig G, Kuschinsky W, Dirnagl U, Laufs U (2003) Mechanisms of stroke protection by physical activity. Ann Neurol 54 (5): 582-590[7,7]

Gertz K, Laufs U, Lindauer U, Nickenig G, Bohm M, Dirnagl U, Endres M (2003) Withdrawal of statin treatment abrogates stroke protection in mice. Stroke 34 (2): 551-557 [5,2]

Laufs U, Gertz K, Dirnagl U, Bohm M, Nickenig G, Endres M (2002) Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 942 (1-2): 23-30[2,5]

Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, von Harsdorf R, Bruck W, Hortnagl H, Dirnagl U, Bhide PG, Endres M (2001) Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci 21 (14): 5045-5053[8,3]

Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabo C, Endres M (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in vitro and in vivo models of stroke. Int J Mol Med 7 (3): 255-260[1,9]

Laufs U, Gertz K, Huang P, Nickenig G, Bohm M, Dirnagl U, Endres M (2000) Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke 31 (10): 2442-2449[5,2]

Prass K, Wiegand F, Schumann P, Ahrens M, Kapinya K, Harms C, Liao W, Trendelenburg G, Gertz K, Moskowitz MA, Knapp F, Victorov IV, Megow D, Dirnagl U (2000) Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent. Brain Res 871 (1): 146-150[2,5]

Laufs U, Endres M, Custodis F, Gertz K, Nickenig G, Liao JK, Bohm M (2000) Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 102 (25): 3104-3110[11,2]

Karen Gertz

Berlin, 21. September 2004