1 . Spatz H, Jauch KW: Tumorzelldissemination beim Pankreaskarzinom- Besonderheiten und prognostische Wertigkeit. 10.02.2003,

2 . Böttger T, Engelmann R, Seifert JK, Löw R, Junginger T: Preoperative diagnostics in pancreatic carcinoma: would less be better? Langenbeck`s Arch Surg 383: 243-248, 1998

3 . Bansal P, Sonnenberg A: Pancreatits is a risk factor for pancreatic cancer. Gastroenterology 109: 247-251, 1995.

4 . Riede UN, Stolte M: Pankreaskarzinome, Riede UN, Schaefer HE: Allgemeine und spezielle Pathologie, 4. Auflage,

5 . Warshaw AL, del Fernandez CC: Pancreatic carcinoma. N Engl J Med 326: 455-465, 1992.

6 . Nitecki SS, Sarr MG, Colby TV, van Heerden JA: Long-term survival after resection for ductal adenocarcinoma of the pancreas: is it really improving? Ann Surg 221: 59-66, 1995.

7 . Müller MF, Meyenberger C, Bertschinger P et al: Pancreatic tumors: evaluation with endoscopic US, CT and MRI imaging. Radiology190: 745-751, 1994.

8 . Ichikawa T, Haradome H, Hachiya J et al: Pancreatic ductal adenocarcinoma: preoperative assessment with helical CT versus dynamic MR imaging. Radiology 202: 655-662, 1997.

9 . Gmeinwieser J, Feuerbach S, Hohenberger W et al: Spiral-CT in diagnosis of vascular involvement in pancreatic cancer. Hepatogastroenterology 42: 418-422, 1995.

10 . Lentschig MG, Reimer P, Rummeny E et al: Die Wertigkeit der 3-Phasen-Spiral-CT und der Magnetresonanztomographie in der präoperativen Diagnostik des Pankreaskarzinoms. Radiologe 36: 406-412, 1996.

11 . Semelka RC, Arscher SM: MR imaging of the pancreas. Radiology (3) 188: 593-602, 1993.

12 . Brown ED, Semelka RC: Magnetic resonance imaging of the spleen and pancreas. Top Magn Reson Imaging7 (2): 82-89, 1995.

13 . Irie H, Honda H, Kaneko K, Kuroiwa T, Yoshimitsu K, Masuda K: Comparison of helical CT and MR imaging in detecting and staging small pancreatic adenocarcinoma. Abdominal Imaging 22: 429-433, 1997.

14 . Lopez Hänninen E, Amthauer H, Hosten N, Ricke J et al: Prospective evaluation of pancreatic tumors: accuracy of MR imaging with MR cholangiography and MR angiography. Radiology 224: 34-41, 2002.

15 . Catalano C, Pavone P, Laghi A et al: Pancreatic adenocarcinoma: combination of MR imaging, MR angiography, MR cholangiopancreaticography for the diagnosis and assessment of respectability. Eur Radiology 8: 428-434, 1998.

16 . Gaa J, Laub G, Edelmann RR et al: Erste klinische Ergebnisse mit der ultraschnellen, kontrastverstärkten 2-Phasen 3-D-MR-Angiographie im Abdomen. Fortschr Röntgenstr169: 1-5, 1998.

17 . Stehling MK, Holzknecht N, Laub G: Gadolinium-verstärkte Magnetresonanz-tomographie der Abdominalgefäße. Radiologe 37: 539-546, 1997.

18 . Delbeke D, Rose DM, Chapman WC, Pinson W, Wright JK, Beauchamp RD, Shyr Y, Leach SD: Optimal Interpretation of FDG PET in the Diagnosis, Staging and Management of Pancreatic Carcinoma. J Nucl Med (11) 40: 1784-1791, 1999.

19 . Fernandez-del Castillo C, Rattner DW, Warshaw AL: Further experience with laparoscopy and peritoneal cytology in staging for pancreatic cancer. Br J Surg 82: 1127-1129, 1995

20 . Landis SH, Murray T, Bolden S, Wingo PA: Cancer statistics. CA Cancer J Clin 4: 8 6-29, 1998.

21 . Maiman TH: Biomedical lasers evolve toward clinical applications. Hosp Manage 101: 39-41, 1996.

22 . Bown SG: Phototherapy of tumors. World J Surg 7: 700-709, 1983.

23 . Ascher PW, Justich E, Schrottner O: Interstitial thermotherapy of central brain tumors with Nd:YAG laser under real-time monitoring by MRI. J Clin Laser Med Surg (1) 9: 79-83, 1991.

24 . Auer LM, Ascher PW, Heppner F, Ladurner G, Bone G, Lechner H, Tolly E: Does acute endoscopic evacuation improve the outcome of patients with spontaneous intracerebral hemorrhage? Eur Neurol (4) 24: 254-261, 1985.

25 . Higuchi N, Bleier AR, Jolesz FA, Colucci VM, Morris JH: MRI of the acute effects of interstitial Nd:YAG laser irradiation on tissues. Invest Radiol 27: 814-821, 1992.

26 . Anzai Y, Lufkin RB, Castro DJ, Farahani K, Jabour BA, Layfield LJ, Udkoff R, Hanafee WN: MR imaging-guided interstitial Nd:YAG laser phototherapy: Dosimetry studi of acute tissue damage in an in-vivo model. J Magnet Res Imaging 1: 553-559, 1991.

27 . Masters A, Bown SG: Interstitial laser hyperthermia. Semin Surg Oncol 8: 242-249, 1992.

28 . Van Beuningen D: Hyperthermie als zytotoxisches und strahlensensibilisierendes Agens: zelluläre Effekte. Strahlentherapie 159: 60-66, 1983.

29 . Hiele M, Penninckx F, Gevers AM, Van Eyken P et al: Interstitial thermotherapy for liver tumors: Studie of different fibers and radiation characteristics. Laser Med Science 8: 121-126, 1993.

30 . Dalannoy J, Ching-Nien Chen, Turner R, Levin RL, Le Bihan D: Noninvasive temperature imaging using diffusion MRI. Magn Reson Med 19: 333-339, 1991.

31 . Huang GT, Wang TH, Sheu JC, Daikuzono N et al: Low-power laserthermia for treatment of small hepatocellular carcinoma. Eur J Cancer 27: 1622- 1627, 1991.

32 . Svaasand LO, Boerlid T, Oeveraasen M: Thermal and optical properties of living tissue: application laser-induced hyperthermia. Lasers Surg Med 5: 589-602, 1985.

33 . Roggan A, Müller G: Dosimetry and computer based irradiation planning for laser-induced interstitial thermotherapy (LITT) SPIE- The International Society for Optical Engineering Press Laser-induced Interstitial Thermotherapy.

34 . Vogl TJ, Mack M, Straub R, Eichler K, Engelmann K, Roggan A, Zangos S: Perkutane interstitielle Thermotherapie maligner Lebertumoren. Forschr Röntgenstr 172: 12-22, 2000.

35 . Anzai Y, Lufkin R, De Salles A et al: Prelimanary experience with MR-guided thermal ablation of brain tumors. AJNR 16: 39-48, 1995.

36 . Jäger L, Müller-Lisse GU, Gutmann R, Feyh J, Thoma M, Reiser M: Erste Ergebnisse der MRT-gesteuerten laserinduzierten interstitiellen Thermotherapie von Kopf- und Halstumoren. Radiologe 36: 236-244, 1996.

37 . Akimov AB, Seregin VE, Rusanov KV, Tyurina EG, Glushko TA, Nevzorov VP, Nevzorova OF, Akimova EV: Nd:YAG interstitial laser thermotherapy in the treatment of breast cancer. Lasers in Surgery and Medicine 22: 257-267, 1998.

38 . Bleier AR, Jolesz FA, Cohen MS, et al: Real-time magnetic resonance imaging of laser heat deposition in tissue. Magn Reson Med 21: 132-137, 1991.

39 . Castro DJ, Saxton RE, Layfield LJ, et al: Interstitial laser phototherapy assisted by magnetic resonance imaging: a new technique for monitoring laser-tissue interaction. Laryngoscope 100: 541-547, 1990.

40 . Dickinson AR, Hall AS, Hind AJ, Young IR: Measurement of changes in tissue temperature using MR imaging. J Comput Assist Tomogr 10: 486-472, 1986.

41 . Matsumoto R, Selig AM, Colucci VM et al: Interstitial Nd:YAG laser ablation in normal rabbit liver; Trial to maximize the size of laser-induced lesions. Laser Surg Med 12: 650-658, 1992.

42 . Haase A: Snapshot FLASH MRI. Applications to T1, T2 and Chemical-Shift Imaging. Magnetic Resonance in Medicine 13: 77-89, 1990.

43 . Müller-Lisse GU, Heuck A, Stehling MK: MRT-Monitoring vor, während und nach der interstitiellen laserinduzierten Thermotherapie der benignen Prostatahyperplasie Erste klinischer Erfahrungen. Der Radiologe 36: 722-731, 1996.

44 . Probst A, Henninger W, Willmann M, Bergmeister H, Losert U: CT-Anatomie des Pankreas beim Schwein in der medizinischen Forschung. Wiener Tierärztliche Monatsschrift 85: 352-358, 1998.

45 . Dondelinger RF, Ghysels MP, Brisbois P: Relevant radiological anatomy of the pig as a training model in interventional radiology. Eur Radiol 8: 1254-1273, 1998.

46 . Georgi M, Gaa J, Lehmann KJ, Diehl S, Jungius KP: Aktuelle Entwicklung in der radiologischen Diagnostik von Pankreaserkrankungen. Röntgenpraxis 51: 191-202, 1998.

47 . Kelly DM, Benjamin GS: Pancreatic carcinoma. Ann Oncol 6: 19-28, 1995.

48 . Cascinu S, Silva RR, Barni S et al: A combinationof gemcitabine and 5-fluorouracil in advanced panceatic cancer, a report from the Italien Group for the Study of Digestive Tract Cancer (GISCAD). Br J Cancer 80: 1595-1598, 1999.

49 . Seki T, Wakabayashi M, Nakagawa T et al: Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma. Cancer 74: 817-825, 1994.

50 . Merkle EM, Haaga JR, Duerk JL, Jacobs GH, Brambs H-J, Lewin JS: MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system. Radiology 213;2: 461-467, 1999.

51 . Murakami R, Yoshimatsu S, Yamashita Y, Matsukawa T, Takahashi M, Sagara K: Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation. AJR 164: 1159-1164, 1995.

52 . Tacke J, Adam G, Speetzen R et al: MR-guided interstitial cryotherapy of the liver with a novel, nitrogen-cooled cryoprobe. Magn Reson Med 39: 354-360, 1998.

53 . McDannold NJ, Hynynen K, Wolf D, Wolf G, Jolesz F: MRI evaluation of thermal ablation of tumors with focused ultrasound. JMRI 8: 91-100, 1998.

54 . Matsui Y, Nakagawa A, Kamiyama Y, Yamamoto K, Kubo N, Nakase Y: Selective Thermocaogulation of unresectable pancreatic cancers by using radiofrequency capacitive heating. Pancreas (1) 20: 14-20, 2000.

55 . Thomson S: Pathologic analysis of photothermal and photomechanical effects of laser-tissue interaction. Photochem Photobiol 53: 825-835, 1991.

56 . Lepock JR, Frey HE, Ritchie KP: Protein denaturation in intact hepatocytes and isolated organelles during heat shock. J Cell Biol 122: 1267-1276, 1993.

57 . Heiserkamp J, v. Hillegersberg R, Ijzermans JNM: Critical temperature and heating time for coagulation damage: implications for interstitial laser coagulation (ILC) of tumors. Lasers in Surgery and Medicine 25: 257-262, 1999.

58 . Orth K, Russ D, Steiner R, Beger HG: Dynamische interstitielle Laserapplikation zur Therapie sekundärer Lebertumoren. Chirurg 68: 1268-1274, 1997.

59 . Vogl TJ, Mack MG, Roggan A, Straub R, Eichler KC, Müller PK, Knappe V, Felix R: Internally colled power laser for MR-guided interstitial laser-induced thermotherapy of liver lesions: initial clinical results. Radiology 209: 381-385, 1998.

60 . Kahn T, Schwabe B, Bettag M, Harth T, Ulrich F, Rassek M, Schwarzmaier HJ, Mödder U: Mapping of the cortical motor hand area with functional MR imaging and MR imaging-guided laser-induced interstitial thermotherapy of brain tumors. Radiology 200: 149-157, 1996.

61 . Vogl TJ, Mack MG, Müller P, Philipp C, Juergens M, Knöbber D, Roggan A, Wust P, Jahnke V, Felix R: MR-gesteuerte laserinduzierte Thermotherapie bei Tumoren in der Kopf-Hals-Region: Erste klinische Ergebnisse. Forschr Röntgenstr 163: 505-514, 1995.

62 . Tracz RA, Wyman DR, Little PB, Towner RA et al: Comparison of magnetic resonance images and the histopathological findings of lesions induces by interstitial laser photocoagulation in the brain. Lasers in Surgery and Medicine 13: 45-54, 1993.

63 . Mumtaz H, Hall-Craggs MA, Wotherspoon A, Paley M, Buonaccorsi G, Amin Z, Wilkinson I, Kissin MW, Davidson TI, Taylor I, Bown SG: Laser therapy for breast cancer: MR imaging and histopathologic correlation. Radiology 200: 651-658, 1996.

64 . Mueller-Lisse UG, Thoma M, Faber S et al: Coagulative interstitial laser-induced thermotherapy of benign prostatic hyperplasia: online imaging with a T2-weighted fast spin-echo MR sequence- experience in six patients. Radiology 210: 373-379, 1999.

65 . Vogl TJ, Mack MG, Straub R et al: Interventionelle MR-gesteuerte laserinduzierte Thermotherapie bei onkologischen Fragestellungen. Radiologe 39: 764-771, 1999.

66 . Dachmann AH, McGehee JA, Beam TE, Burris JA, Powell DA: US-guided percutaneous laser ablation of liver tissue in a chronic pig model. Radiology 176: 129-133, 1990.

67 . Frank F, Hessel S: Technical prerequisites for the interstitial thermotherapy with the Nd:YAG laser. Lasermedizin 10: 36-40, 1990.

68 . Castrén-Persons M, Lipasti J, Poulakkainen P, Schröder T: Laserinduced hyperthermia: Comparison of two different methods. Laser Surg Med 12: 665-668, 1992.

69 . Gewiese B, Beuthan J, Fobbe F: Magnetic resonance imaging-controlled laserinduced interstitial thermotherapy. Invest Radiol (3) 29: 345-351, 1994.

70 . Van Hillegersberg R, Van Staveren HJ, Kort WJ: Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liber metastases. Laser Surg Med (2) 14: 124-138, 1994.

71 . Brandt KR, Charboneau JW, Stephens DH, Welch TJ, Goellner JR: CT- and US-guided biopsy of the pancreas. Radiology 187: 99-104, 1993.

72 . Wacker FK: Interventionelle MRT. Fortschr Röntgenstr 176: 941-943, 2004.

73 . Malone DE, Wyman DR, DeNardi FG, McGrath FP, De Gara CJ, Wilson BC: Hepatic interstitial laser photocoagulation. An investigation of the relationship between acute thermal lesions and their sonographic images. Invest Radiol 29: 915-921, 1994.

74 . Malone DE, Wyman DR, Moote DJ, DeNardi FG et al: Sonographic changes during hepatic interstitial laser photocoagulation. An intervestigation of three optical fiber tips. Invest Radiol 27: 804-813, 1992.

75 . Goldberg SN, Mallery S, Gazelle GS et al: EUS-guided radiofrequency ablation in the pancreas: results in a porcine model. Gastrointestinal Endoscopy 503: 392-401, 1999.

76 . Vogl TJ, Müller PK, Hammerstingl R et al: Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results. Radiology 196: 257-265, 1995.

77 . Rummeny EJ, Peters PE: Stand der Entwicklung neuer klinischer Kontrastmittel für die MR-Diagnostik von Lebererkrankungen. Radiologie 32: 225-231, 1992.

78 . Lees WR, Gilliams AR, Whitelaw D, Bown SG, Hatfield AR: CT guided percutaneous treatment of pancreatic cancer with photodynamic therapy. Radiology (P) 209: 449, 1998.

79 . Jolesz FA, Bleier AR, Jakab: MR imaging of laser-tissue interactions. Radiology 168: 249-253, 1988.

80 . Anzai Y, Lufkin RB, Hirschowitz S, Castro DJ: MR imaging-Correlation of thermal injuries induced with interstitial Nd:YAG laser irradiation in the chronic model. J Magnet Res Imaging 2: 671-678, 1992.

81 . Beger HG, Poch B, Schwarz M, Gansauge F: Pankreaskarzinom: Stellenwert der neoadjuvanten Therapie. Chirurg 74: 202-207, 2003.

82 . Puls R, Kroncke TJ, Kluner C, Gaffke G, Stroszczynski C, Albrecht T, Speck U, Hamm B: Double contrast MRI of thermally ablated liver metastases. ROFO Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr (11) 175: 1467-1470, 2003.

83 . McNichls RJ, Gowda A, Kangasniemi M, Bankson JA, Price RE, Hazle JD: MR thermometry-based feedback control of laser interstitial thermal therapy al 980 nm. Lasers Surg Med (1) 34: 48-55, 2004.