Literaturverzeichnis

1. Mertens, C., Kuhn, C., & Franke, W. W. Plakophilins 2a and 2b: Constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. Journal of Cell Biology 135, 1009-1025 (1996).

2. Riggleman, B., Wieschaus, E., & Schedl, P. Molecular Analysis of the Armadillo-Locus - Uniformly Distributed Transcripts and A Protein with Novel Internal Repeats Are Associated with A Drosophila Segment Polarity Gene. Genes & Development 3, 96-113 (1989).

3. Peifer, M. & Wieschaus, E. The Segment Polarity Gene Armadillo Encodes A Functionally Modular Protein That Is the Drosophila Homolog of Human Plakoglobin. Cell 63, 1167-1178 (1990).

4. Mccrea, P. D., Turck, C. W., & Gumbiner, B. A Homolog of the Armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin. Science 254, 1359-1361 (1991).

5. Butz, S., Stappert, J., Weissig, H., & Kemler, R. Plakoglobin and Beta-Catenin - Distinct But Closely Related. Science 257, 1142-1144 (1992).

6. Peifer, M., Berg, S., & Reynolds, A. B. A Repeating Amino-Acid Motif Shared by Proteins with Diverse Cellular Roles. Cell 76, 789-791 (1994).

7. Franke, W. W. et al. Molecular-Cloning and Amino-Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein. Proceedings of the National Academy of Sciences of the United States of America 86, 4027-4031 (1989).

8. Reynolds, A. B., Herbert, L., Cleveland, J. L., Berg, S. T., & Gaut, J. R. P120, A Novel Substrate of Protein Tyrosine Kinase Receptors and of P60V-Src Is Related to Cadherin-Binding Factors Beta-Catenin, Plakoglobin and Armadillo. Oncogene 7, 2439-2445 (1992).

9. Behrens, J. et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638-642 (1996).

10. Schmidt, A. et al. Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell and Tissue Research 290, 481-499 (1997).

11. Simcha, I. et al. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. Journal of Cell Biology 141, 1433-1448 (1998).

12. Daniel, J. M. & Reynolds, A. B. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Molecular and Cellular Biology 19, 3614-3623 (1999).

13. van de Wetering, M. et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789-799 (1997).

14. Hecht, A., Litterst, C. M., Huber, O., & Kemler, R. Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. Journal of Biological Chemistry 274, 18017-18025 (1999).

15. Kolligs, F. T. et al. gamma-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes & Development 14, 1319-1331 (2000).

16. Zhurinsky, J., Shtutman, M., & Ben Ze'ev, A. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Molecular and Cellular Biology 20, 4238-4252 (2000).

17. Conacci-Sorrell, M. et al. Nr-CAM is a target gene of the beta-catenin/LEF-1 in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes & Development 16, 2058-2072 (2002).

18. Miravet, S. et al. The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin. Journal of Biological Chemistry 277, 1884-1891 (2002).

19. Muller-Tidow, C. et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Molecular and Cellular Biology 24, 2890-2904 (2004).

20. Solanas, G. et al. beta-catenin and plakoglobin N- and C-tails determine ligand specificity. Journal of Biological Chemistry 279, 49849-49856 (2004).

21. Teuliere, J. et al. beta-catenin-dependent and -independent effects of Delta N-plakoglobin on epidermal growth and differentiation. Molecular and Cellular Biology 24, 8649-8661 (2004).

22. Eastman, Q. & Grosschedl, R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Current Opinion in Cell Biology 11, 233-240 (1999).

23. Bienz, M. & Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 103, 311-320 (2000).

24. White, P., Aberle, H., & Vincent, J. P. Signaling and adhesion activities of mammalian beta-catenin and plakoglobin in Drosophila. Journal of Cell Biology 140, 183-195 (1998).

25. Cox, R. T., Pai, L. M., Kirkpatrick, C., Stein, J., & Peifer, M. Roles of the C terminus of Armadillo in wingless signaling in Drosophila. Genetics 153, 319-332 (1999).

26. Piedra, J. et al. Regulation of beta-catenin structure and activity by tyrosine phosphorylation. Journal of Biological Chemistry 276, 20436-20443 (2001).

27. Brembeck, F. H. et al. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes & Development 18, 2225-2230 (2004).

28. Gottardi, C. J. & Gumbiner, B. M. Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. Journal of Cell Biology 167, 339-349 (2004).

29. Palka, H. L. & Green, K. J. Roles of plakoglobin end domains in desmosome assembly. Journal of Cell Science 110, 2359-2371 (1997).

30. Jamora, C. & Fuchs, E. Intercellular adhesion, signalling and the cytoskeleton. Nature Cell Biology 4, E101-E108 (2002).

31. Cowin, P., Kapprell, H. P., Franke, W. W., Tamkun, J., & Hynes, R. O. Plakoglobin - A Protein Common to Different Kinds of Intercellular Adhering Junctions. Cell 46, 1063-1073 (1986).

32. Chang, L. & Goldman, R. D. Intermediate filaments mediate cytoskeletal crosstalk. Nature Reviews Molecular Cell Biology 5, 601-613 (2004).

33. Revenu, C., Athman, R., Robine, S., & Louvard, D. The co-workers of actin filaments: From cell structures to signals. Nature Reviews Molecular Cell Biology 5, 635-646 (2004).

34. Kartenbeck, J., Franke, W. W., Moser, J. G., & Stoffels, U. Specific Attachment of Desmin Filaments to Desmosomal Plaques in Cardiac Myocytes. Embo Journal 2, 735-742 (1983).

35. Kartenbeck, J., Schwechheimer, K., Moll, R., & Franke, W. W. Attachment of Vimentin Filaments to Desmosomal Plaques in Human Meningiomal Cells and Arachnoidal Tissue. Journal of Cell Biology 98, 1072-1081 (1984).

36. Franke, W. W. & Moll, R. Cytoskeletal Components of Lymphoid Organs .1. Synthesis of Cytokeratin-8 and Cytokeratin-18 and Desmin in Subpopulations of Extrafollicular Reticulum Cells of Human Lymph-Nodes, Tonsils, and Spleen. Differentiation 36, 145-163 (1987).

37. Kuruc, N. & Franke, W. W. Transient Coexpression of Desmin and Cytokeratin-8 and Cytokeratin-18 in Developing Myocardial-Cells of Some Vertebrate Species. Differentiation 38, 177-193 (1988).

38. van der Loop, F. T. L., Schaart, G., Langmann, H., Ramaekers, F. C. S., & Viebahn, C. Rearrangement of Intercellular-Junctions and Cytoskeletal Proteins During Rabbit Myocardium Development. European Journal of Cell Biology 68, 62-69 (1995).

39. Allen, E., Yu, Q. C., & Fuchs, E. Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation. Journal of Cell Biology 133, 1367-1382 (1996).

40. Bierkamp, C., McLaughlin, K. J., Schwarz, H., Huber, O., & Kemler, R. Embryonic heart and skin defects in mice lacking plakoglobin. Developmental Biology 180, 780-785 (1996).

41. Ruiz, P. et al. Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. Journal of Cell Biology 135, 215-225 (1996).

42. McGrath, J. A. et al. Mutations in the plakophilin 1 gene result in ectodermal dysplasia skin fragility syndrome. Nature Genetics 17, 240-244 (1997).

43. Rickman, L. et al. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. Human Molecular Genetics 8, 971-976 (1999).

44. Mckoy, G. et al. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet 355, 2119-2124 (2000).

45. Norgett, E. E. et al. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Human Molecular Genetics 9, 2761-2766 (2000).

46. Chidgey, M. et al. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation. Journal of Cell Biology 155, 821-832 (2001).

47. Gallicano, G. I., Bauer, C., & Fuchs, E. Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development 128, 929-941 (2001).

48. Vasioukhin, V., Bowers, E., Bauer, C., Degenstein, L., & Fuchs, E. Desmoplakin is essential in epidermal sheet formation. Nature Cell Biology 3, 1076-1085 (2001).

49. Alcalai, R., Metzger, S., Rosenheck, S., Meiner, V., & Chajek-Shaul, T. A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. Journal of the American College of Cardiology 42, 319-327 (2003).

50. Kljuic, A. et al. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113, 249-260 (2003).

51. McGrath, J. A. Hereditary diseases of desmosomes. Journal of Dermatological Science 20, 85-91 (1999).

52. Chidgey, M. Desmosomes and disease: an update. Histology and Histopathology 17, 1179-1192 (2002).

53. Garrod, D. R., Merritt, A. J., & Nie, Z. X. Desmosomal cadherins. Current Opinion in Cell Biology 14, 537-545 (2002).

54. Franke, W. W. et al. Desmoplakins of Epithelial and Myocardial Desmosomes Are Immunologically and Biochemically Related. Differentiation 23, 115-127 (1982).

55. Schmelz, M. & Franke, W. W. Complexus Adhaerentes, A New Group of Desmoplakin-Containing Junctions in Endothelial-Cells - the Syndesmos Connecting Retothelial Cells of Lymph-Nodes. European Journal of Cell Biology 61, 274-289 (1993).

56. Schmelz, M., Moll, R., Kuhn, C., & Franke, W. W. Complexus Adhaerentes, A New Group of Desmoplakin-Containing Junctions in Endothelial-Cells .2. Different Types of Lymphatic Vessels. Differentiation 57, 97-117 (1994).

57. Valiron, O. et al. Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions. Journal of Cell Science 109, 2141-2149 (1996).

58. Kowalczyk, A. P. et al. VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions. Journal of Cell Science 111, 3045-3057 (1998).

59. Zhou, X. et al. Desmoplakin is required for microvascular tube formation in culture. Journal of Cell Science 117, 3129-3140 (2004).

60. Getsios, S., Huen, A. C., & Green, K. J. Working out the strength and flexibility of desmosomes. Nature Reviews Molecular Cell Biology 5, 271-281 (2004).

61. Koch, P. J. et al. Identification of Desmoglein, A Constitutive Desmosomal Glycoprotein, As A Member of the Cadherin Family of Cell-Adhesion Molecules. European Journal of Cell Biology 53, 1-12 (1990).

62. Amagai, M., Klauskovtun, V., & Stanley, J. R. Autoantibodies Against A Novel Epithelial Cadherin in Pemphigus-Vulgaris, A Disease of Cell-Adhesion. Cell 67, 869-877 (1991).

63. Schafer, S., Koch, P. J., & Franke, W. W. Identification of the Ubiquitous Human Desmoglein, Dsg2, and the Expression Catalog of the Desmoglein Subfamily of Desmosomal Cadherins. Experimental Cell Research 211, 391-399 (1994).

64. Collins, J. E. et al. Cloning and Sequence-Analysis of Desmosomal Glycoprotein-2 and Glycoprotein-3 (Desmocollins) - Cadherin-Like Desmosomal Adhesion Molecules with Heterogeneous Cytoplasmic Domains. Journal of Cell Biology 113, 381-391 (1991).

65. Mechanic, S., Raynor, K., Hill, J. E., & Cowin, P. Desmocollins Form A Distinct Subset of the Cadherin Family of Cell-Adhesion Molecules. Proceedings of the National Academy of Sciences of the United States of America 88, 4476-4480 (1991).

66. Kawamura, K. et al. cDNA Cloning and Expression of A Novel Human Desmocollin. Journal of Biological Chemistry 269, 26295-26302 (1994).

67. Franke, W. W., Mueller, H., Mittnacht, S., Kapprell, H. P., & Jorcano, J. L. Significance of 2 Desmosome Plaque-Associated Polypeptides of Molecular-Weights 75000 and 83000. Embo Journal 2, 2211-2215 (1983).

68. Kapprell, H. P., Owaribe, K., & Franke, W. W. Identification of A Basic-Protein of Mr 75,000 As An Accessory Desmosomal Plaque Protein in Stratified and Complex Epithelia. Journal of Cell Biology 106, 1679-1691 (1988).

69. Schmidt, A. et al. Plakophilin 3 - a novel cell-type-specific desmosomal plaque protein. Differentiation 64, 291-306 (1999).

70. Leung, C. L., Green, K. J., & Liem, R. K. H. Plakins: a family of versatile cytolinker proteins. Trends in Cell Biology 12, 37-45 (2002).

71. Green, K. J. & Gaudry, C. A. Are desmosomes more than tethers for intermediate filaments? Nature Reviews Molecular Cell Biology 1, 208-216 (2000).

72. Cowin, P., Franke, W. W., Grund, & Kapprell, H. P. The Desmosome-Intermediate Filament complex. In G.M. Edelman & J.P. Thiery (Eds.), The cell in contact: Adhesion and Junctions as morphogenetic determinants. New York: Wiley and Sons 427-460 (1985).

73. Watt, F. M., Mattey, D. L., & Garrod, D. R. Calcium-Induced Reorganization of Desmosomal Components in Cultured Human Keratinocytes. Journal of Cell Biology 99, 2211-2215 (1984).

74. Jones, J. C. R. & Goldman, R. D. Intermediate Filaments and the Initiation of Desmosome Assembly. Journal of Cell Biology 101, 506-517 (1985).

75. Holton, J. L. et al. Desmosomal Glycoprotein-2 and Glycoprotein-3 (Desmocollins) Show N-Terminal Similarity to Calcium-Dependent Cell Cell-Adhesion Molecules. Journal of Cell Science 97, 239-246 (1990).

76. Koch, P. J., Goldschmidt, M. D., Walsh, M. J., Zimbelmann, R., & Franke, W. W. Complete Amino-Acid-Sequence of the Epidermal Desmoglein Precursor Polypeptide and Identification of A 2Nd Type of Desmoglein Gene. European Journal of Cell Biology 55, 200-208 (1991).

77. Nilles, L. A. et al. Structural-Analysis and Expression of Human Desmoglein - A Cadherin-Like Component of the Desmosome. Journal of Cell Science 99, 809-821 (1991).

78. Parker, A. E. et al. Desmosomal Glycoprotein-Ii and Glycoprotein-Iii - Cadherin-Like Junctional Molecules Generated by Alternative Splicing. Journal of Biological Chemistry 266, 10438-10445 (1991).

79. Wheeler, G. N. et al. Desmosomal Glycoprotein Dgi, A Component of Intercellular Desmosome Junctions, Is Related to the Cadherin Family of Cell-Adhesion Molecules. Proceedings of the National Academy of Sciences of the United States of America 88, 4796-4800 (1991).

80. Buxton, R. S. et al. Nomenclature of the Desmosomal Cadherins. Journal of Cell Biology 121, 481-483 (1993).

81. Angst, B. D., Marcozzi, C., & Magee, A. I. The cadherin superfamily: diversity in form and function. Journal of Cell Science 114, 629-641 (2001).

82. Whittock, N. V. & Bower, C. Genetic evidence for a novel human desmosomal cadherin, desmoglein 4. Journal of Investigative Dermatology 120, 523-530 (2003).

83. Korman, N. J., Eyre, R. W., Klauskovtun, V., & Stanley, J. R. Demonstration of An Adhering-Junction Molecule (Plakoglobin) in the Auto-Antigens of Pemphigus Foliaceus and Pemphigus Vulgaris. New England Journal of Medicine 321, 631-635 (1989).

84. Mathur, M., Goodwin, L., & Cowin, P. Interactions of the Cytoplasmic Domain of the Desmosomal Cadherin Dsg1 with Plakoglobin. Journal of Biological Chemistry 269, 14075-14080 (1994).

85. Koch, P. J., Goldschmidt, M. D., Zimbelmann, R., Troyanovsky, R., & Franke, W. W. Complexity and Expression Patterns of the Desmosomal Cadherins. Proceedings of the National Academy of Sciences of the United States of America 89, 353-357 (1992).

86. Nuber, U. A., Schafer, S., Schmidt, A., Koch, P. J., & Franke, W. W. The Widespread Human Desmocollin Dsc2 and Tissue-Specific Patterns of Synthesis of Various Desmocollin Subtypes. European Journal of Cell Biology 66, 69-74 (1995).

87. Green, K. J., Goldman, R. D., & Chisholm, R. L. Isolation of cDNAs Encoding Desmosomal Plaque Proteins - Evidence That Bovine Desmoplakin-I and Desmoplakin-Ii Are Derived from 2 Messenger-Rnas and A Single Gene. Proceedings of the National Academy of Sciences of the United States of America 85, 2613-2617 (1988).

88. Virata, M. L. A., Wagner, R. M., Parry, D. A. D., & Green, K. J. Molecular-Structure of the Human Desmoplakin-I and Desmoplakin-Ii Amino Terminus. Proceedings of the National Academy of Sciences of the United States of America 89, 544-548 (1992).

89. Cowin, P., Kapprell, H. P., & Franke, W. W. The Complement of Desmosomal Plaque Proteins in Different Cell-Types. Journal of Cell Biology 101, 1442-1454 (1985).

90. Angst, B. D., Nilles, L. A., & Green, K. J. Desmoplakin-Ii Expression Is Not Restricted to Stratified Epithelia. Journal of Cell Science 97, 247-257 (1990).

91. O´Keefe, E. J., Erickson, H. P., & Bennett, V. Desmoplakin-I and Desmoplakin-Ii - Purification and Characterization. Journal of Biological Chemistry 264, 8310-8318 (1989).

92. Stappenbeck, T. S. & Green, K. J. The Desmoplakin Carboxyl Terminus Coaligns with and Specifically Disrupts Intermediate Filament Networks When Expressed in Cultured-Cells. Journal of Cell Biology 116, 1197-1209 (1992).

93. Stappenbeck, T. S. et al. Functional-Analysis of Desmoplakin Domains - Specification of the Interaction with Keratin Versus Vimentin Intermediate Filament Networks. Journal of Cell Biology 123, 691-705 (1993).

94. Kouklis, P. D., Hutton, E., & Fuchs, E. Making A Connection - Direct Binding Between Keratin Intermediate Filaments and Desmosomal Proteins. Journal of Cell Biology 127, 1049-1060 (1994).

95. Kowalczyk, A. P. et al. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. Journal of Cell Biology 139, 773-784 (1997).

96. Kowalczyk, A. P. et al. The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes - Implications for cutaneous disease. Journal of Biological Chemistry 274, 18145-18148 (1999).

97. Chitaev, N. A. et al. The binding of plakoglobin to desmosomal cadherins: Patterns of binding sites and Topogenic potential. Journal of Cell Biology 133, 359-369 (1996).

98. Wahl, J. K. et al. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: Identification of unique and shared domains. Journal of Cell Science 109, 1143-1154 (1996).

99. Witcher, L. L. et al. Desmosomal cadherin binding domains of plakoglobin. Journal of Biological Chemistry 271, 10904-10909 (1996).

100. Choi, H. J. & Weis, W. I. Structure of the armadillo repeat domain of plakophilin 1. Journal of Molecular Biology 346, 367-376 (2005).

101. Chen, X. Y., Bonne, S., Hatzfeld, M., van Roy, F., & Green, K. J. Protein binding and functional characterization of plakophilin 2 - Evidence for its diverse roles in desmosomes and beta-catenin signaling. Journal of Biological Chemistry 277, 10512-10522 (2002).

102. Huber, A. H., Nelson, W. J., & Weis, W. I. Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 90, 871-882 (1997).

103. Bornslaeger, E. A. et al. Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders. Journal of Cell Science 114, 727-738 (2001).

104. South, A. P. et al. Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. Journal of Cell Science 116, 3303-3314 (2003).

105. Smith, E. A. & Fuchs, E. Defining the interactions between intermediate filaments and desmosomes. Journal of Cell Biology 141, 1229-1241 (1998).

106. Hatzfeld, M., Haffner, C., Schulze, K., & Vinzens, U. The function of plakophilin 1 in desmosome assembly and actin filament organization. Journal of Cell Biology 149, 209-222 (2000).

107. Hofmann, I. et al. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. Journal of Cell Science 113, 2471-2483 (2000).

108. Hatzfeld, M., Kristjansson, G. I., Plessmann, U., & Weber, K. Band-6 Protein, A Major Constituent of Desmosomes from Stratified Epithelia, Is A Novel Member of the Armadillo Multigene Family. Journal of Cell Science 107, 2259-2270 (1994).

109. Bonne, S., van Hengel, J., Nollet, F., Kools, P., & van Roy, F. Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells. Journal of Cell Science 112, 2265-2276 (1999).

110. Bonne, S. et al. Defining desmosomal plakophilin-3 interactions. Journal of Cell Biology 161, 403-416 (2003).

111. Hatzfeld, M. & Nachtsheim, C. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: Evidence for a subfamily of closely related proteins. Journal of Cell Science 109, 2767-2778 (1996).

112. Hatzfeld, M., Green, K. J., & Sauter, H. Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. Journal of Cell Science 116, 1219-1233 (2003).

113. Reynolds, A. B. et al. Identification of A New Catenin - the Tyrosine Kinase Substrate P120(Cas) Associates with E-Cadherin Complexes. Molecular and Cellular Biology 14, 8333-8342 (1994).

114. Shibamoto, S. et al. Association of P120, A Tyrosine Kinase Substrate, with E-Cadherin/Catenin Complexes. Journal of Cell Biology 128, 949-957 (1995).

115. Staddon, J. M., Smales, C., Schulze, C., Esch, F. S., & Rubin, L. L. P120, A P120-Related Protein (P100), and the Cadherin Catenin Complex. Journal of Cell Biology 130, 369-381 (1995).

116. Paffenholz, R. & Franke, W. W. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation 61, 293-304 (1997).

117. Paffenholz, R., Kuhn, C., Grund, C., Stehr, S., & Franke, W. W. The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. Experimental Cell Research 250, 452-464 (1999).

118. Anastasiadis, P. Z. & Reynolds, A. B. The p120 catenin family: complex roles in adhesion, signaling and cancer. Journal of Cell Science 113, 1319-1334 (2000).

119. Mertens, C. Plakophilin 2: ein neues Cytoskelettprotein mit molekularen Interaktionen im Zellkern und in Zellverbindungen. Doktorarbeit. Ruprecht-Karls-Universität Heidelberg, Heidelberg, Deutschland. 161 Seiten. (1999).

120. Mertens, C., Kuhn, C., Moll, R., Schwetlick, I., & Franke, W. W. Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues. Differentiation 64, 277-290 (1999).

121. Mertens, C. et al. Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Proceedings of the National Academy of Sciences of the United States of America 98, 7795-7800 (2001).

122. Müller, J., Ritt, D. A., Copeland, T. D., & Morrison, D. K. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. Embo Journal 22, 4431-4442 (2003).

123. Boller, K., Vestweber, D., & Kemler, R. Cell-Adhesion Molecule Uvomorulin Is Localized in the Intermediate Junctions of Adult Intestinal Epithelial-Cells. Journal of Cell Biology 100, 327-332 (1985).

124. Nagafuchi, A. & Takeichi, M. Transmembrane Control of Cadherin-Mediated Cell-Adhesion - A 94 Kda Protein Functionally Associated with A Specific Region of the Cytoplasmic Domain of E-Cadherin. Cell Regulation 1, 37-44 (1989).

125. Ozawa, M., Baribault, H., & Kemler, R. The Cytoplasmic Domain of the Cell-Adhesion Molecule Uvomorulin Associates with 3 Independent Proteins Structurally Related in Different Species. Embo Journal 8, 1711-1717 (1989).

126. Hulsken, J., Birchmeier, W., & Behrens, J. E-Cadherin and Apc Compete for the Interaction with Beta-Catenin and the Cytoskeleton. Journal of Cell Biology 127, 2061-2069 (1994).

127. Ranscht, B. Cadherins and Catenins - Interactions and Functions in Embryonic-Development. Current Opinion in Cell Biology 6, 740-746 (1994).

128. Aberle, H., Schwartz, H., & Kemler, R. Cadherin-catenin complex: Protein interactions and their implications for cadherin function. Journal of Cellular Biochemistry 61, 514-523 (1996).

129. Conacci-Sorrell, M., Zhurinsky, J., & Ben Ze'ev, A. The cadherin-catenin adhesion system in signaling and cancer. Journal of Clinical Investigation 109, 987-991 (2002).

130. Geiger, B., Volk, T., & Volberg, T. Molecular Heterogeneity of Adherens Junctions. Journal of Cell Biology 101, 1523-1531 (1985).

131. Jackson, B. W. et al. Formation of Cytoskeletal Elements During Mouse Embryogenesis - Intermediate Filaments of the Cytokeratin Type and Desmosomes in Pre-Implantation Embryos. Differentiation 17, 161-179 (1980).

132. Jackson, B. W., Grund, C., Winter, S., Franke, W. W., & Illmensee, K. Formation of Cytoskeletal Elements During Mouse Embryogenesis .2. Epithelial Differentiation and Intermediate-Sized Filaments in Early Postimplantation Embryos. Differentiation 20, 203-216 (1981).

133. Franke, W. W., Grund, C., Kuhn, C., Jackson, B. W., & Illmensee, K. Formation of Cytoskeletal Elements During Mouse Embryogenesis .3. Primary Mesenchymal Cells and the 1St Appearance of Vimentin Filaments. Differentiation 23, 43-59 (1982).

134. Franke, W. W., Grund, C., Jackson, B. W., & Illmensee, K. Formation of Cytoskeletal Elements During Mouse Embryogenesis .4. Ultrastructure of Primary Mesenchymal Cells and Their Cell-Cell Interactions. Differentiation 25, 121-141 (1983).

135. Vasioukhin, V., Bauer, C., Yin, M., & Fuchs, E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 100, 209-219 (2000).

136. Gumbiner, B., Stevenson, B., & Grimaldi, A. The Role of the Cell-Adhesion Molecule Uvomorulin in the Formation and Maintenance of the Epithelial Junctional Complex. Journal of Cell Biology 107, 1575-1587 (1988).

137. Lewis, J. E. et al. Cross-talk between adherens junctions and desmosomes depends on plakoglobin. Journal of Cell Biology 136, 919-934 (1997).

138. Koeser, J., Troyanovsky, S. M., Grund, C., & Franke, W. W. De novo formation of desmosomes in cultured cells upon transfection of genes encoding specific desmosomal components. Experimental Cell Research 285, 114-130 (2003).

Borrmann, C. Molekulare Charakterisierung der Adhärenz-Zellverbindungen des Herzens: Identifizierung einer neuen Art, der Area composita. Doktorarbeit. Universität von Heidelberg, Heidelberg, Deutschland. 119 Seiten. (2000).

140. Hatsell, S. & Cowin, P. Deconstructing desmoplakin. Nature Cell Biology 3, E270-E272 (2001).

141. Gallicano, G. I. et al. Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. Journal of Cell Biology 143, 2009-2022 (1998).

142. Eshkind, L. et al. Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. European Journal of Cell Biology 81, 592-598 (2002).

143. Stanley, J. R., Koulu, L., Klauskovtun, V., & Steinberg, M. S. A Monoclonal-Antibody to the Desmosomal Glycoprotein Desmoglein-1 Binds the Same Polypeptide As Human Autoantibodies in Pemphigus Foliaceus. Journal of Immunology 136, 1227-1230 (1986).

144. Amagai, M., Koch, P. J., Nishikawa, T., & Stanley, J. R. Pemphigus vulgaris antigen (Desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. Journal of Investigative Dermatology 106, 351-355 (1996).

145. Koch, P. J. et al. Targeted disruption of the pemphigus vulgaris antigen (Desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. Journal of Cell Biology 137, 1091-1102 (1997).

146. Montagutelli, X., Lalouette, A., Boulouis, H. J., Guenet, J. L., & Sundberg, J. P. Vesicle formation and follicular root sheath separation in mice homozygous for deleterious alleles at the balding (bal) locus. Journal of Investigative Dermatology 109, 324-328 (1997).

147. Whittock, N. V. et al. Genomic amplification of the human plakophilin 1 gene and detection of a new mutation in ectodermal dysplasia/skin fragility syndrome. Journal of Investigative Dermatology 115, 368-374 (2000).

148. Hamada, T. et al. Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1. Experimental Dermatology 11, 107-114 (2002).

149. Sprecher, E. et al. Homozygous splice site mutations in PKP1 result in loss of epidermal plakophilin 1 expression and underlie ectodermal dysplasia/skin fragility syndrome in two consanguineous families. Journal of Investigative Dermatology 122, 647-651 (2004).

150. Rampazzo, A. et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. American Journal of Human Genetics 71, 1200-1206 (2002).

151. Keith, D. et al. Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Human Molecular Genetics 8, 143-148 (1999).

152. Whittock, N. V. et al. Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency. Journal of Investigative Dermatology 113, 940-946 (1999).

153. Arnemann, J., Sullivan, K. H., Magee, A. I., King, I. A., & Buxton, R. S. Stratification-Related Expression of Isoforms of the Desmosomal Cadherins in Human Epidermis. Journal of Cell Science 104, 741-750 (1993).

154. Legan, P. K. et al. The Bovine Desmocollin Family - A New Gene and Expression Patterns Reflecting Epithelial-Cell Proliferation and Differentiation. Journal of Cell Biology 126, 507-518 (1994).

155. Hunt, D. M. et al. Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma. European Journal of Human Genetics 9, 197-203 (2001).

156. Protonotarios, N. et al. Cardiac Abnormalities in Familial Palmoplantar Keratosis. British Heart Journal 56, 321-326 (1986).

157. Thomas, K. R. & Capecchi, M. R. Site-Directed Mutagenesis by Gene Targeting in Mouse Embryo-Derived Stem-Cells. Cell 51, 503-512 (1987).

158. Sedmera, D., Pexieder, T., Vuillemin, M., Thompson, R. P., & Anderson, R. H. Developmental patterning of the myocardium. Anatomical Record 258, 319-337 (2000).

159. Gerull, B. et al. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nature Genetics 36, 1162-1164 (2004).

160. Bornslaeger, E. A., Corcoran, C. M., Stappenbeck, T. S., & Green, K. J. Breaking the connection: Displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. Journal of Cell Biology 134, 985-1001 (1996).

161. Pasdar, M. & Nelson, W. J. Kinetics of Desmosome Assembly in Madin-Darby Canine Kidney Epithelial-Cells - Temporal and Spatial Regulation of Desmoplakin Organization and Stabilization Upon Cell Cell Contact .1. Biochemical-Analysis. Journal of Cell Biology 106, 677-685 (1988).

162. Pasdar, M., Li, Z., & Chan, H. Desmosome Assembly and Disassembly Are Regulated by Reversible Protein-Phosphorylation in Cultured Epithelial-Cells. Cell Motility and the Cytoskeleton 30, 108-121 (1995).

163. Boneko, V. M. & Merker, H. J. Development and Morphology of the Periderm of Mouse Embryos (Days 9-12 of Gestation). Acta Anatomica 133, 325-336 (1988).

164. McKenna, W. J. et al. Diagnosis of Arrhythmogenic Right-Ventricular Dysplasia/Cardiomyopathy. British Heart Journal 71, 215-218 (1994).

165. Gemayel, C., Pelliccia, A., & Thompson, P. D. Arrhythmogenic right ventricular cardiomyopathy. Journal of the American College of Cardiology 38, 1773-1781 (2001).

166. Ahmad, F. The molecular genetics of arrhythmogenic right ventricular dysplasia-cardiomyopathy. Clinical and Investigative Medicine-Medecine Clinique et Experimentale 26, 167-178 (2003).

167. Liew, C. C. & Dzau, V. J. Molecular genetics and genomics of heart failure. Nature Reviews Genetics 5, 811-825 (2004).

168. Rampazzo, A. et al. The Gene for Arrhythmogenic Right-Ventricular Cardiomyopathy Maps to Chromosome 14Q23-Q24. Human Molecular Genetics 3, 959-962 (1994).

169. Rampazzo, A. et al. A New Locus for Arrhythmogenic Right-Ventricular Cardiomyopathy (Arvd2) Maps to Chromosome 1Q42-Q43. Human Molecular Genetics 4, 2151-2154 (1995).

170. Severini, G. M. et al. A new locus for arrhythmogenic right ventricular dysplasia on the long arm of chromosome 14. Genomics 31, 193-200 (1996).

171. Rampazzo, A. et al. ARVD4, a new locus for arrhythmogenic right ventricular cardiomyopathy, maps to chromosome 2 long arm. Genomics 45, 259-263 (1997).

172. Ahmad, F. et al. Localization of a gene responsible for arrhythmogenic right ventricular dysplasia to chromosome 3p23. Circulation 98, 2791-2795 (1998).

173. Coonar, A. S. et al. Gene for arrhythmogenic right ventricular cardiomyopathy with diffuse nonepidermolytic palmoplantar keratoderma and woolly hair (Naxos disease) maps to 17q21. Circulation 97, 2049-2058 (1998).

174. Melberg, A. et al. Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy linked to chromosome 10q. Annals of Neurology 46, 684-692 (1999).

175. Li, D. X. et al. The locus of a novel gene responsible for arrhythmogenic right-ventricular dysplasia characterized by early onset and high penetrance maps to chromosome 10p12-p14. American Journal of Human Genetics 66, 148-156 (2000).

176. Tiso, N. et al. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Human Molecular Genetics 10, 189-194 (2001).

177. Basso, C. et al. Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs - A new animal model of human disease. Circulation 109, 1180-1185 (2004).

178. Kirchhof, P. et al. Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice. Journal of Molecular and Cellular Cardiology 36, 691-700 (2004).

179. Ozcelik, C. et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America 99, 8880-8885 (2002).

180. Zagorski, J., Debelak, J., Gellar, M., Watts, J. A., & Kline, J. A. Chemokines accumulate in the lungs of rats with severe pulmonary embolism induced by polystyrene microspheres. Journal of Immunology 171, 5529-5536 (2003).

181. Geisterfer-Lowrance, A. A. T. et al. A Molecular-Basis for Familial Hypertrophic Cardiomyopathy - A Beta-Cardiac Myosin Heavy-Chain Gene Missense Mutation. Cell 62, 999-1006 (1990).

182. Geisterfer-Lowrance, A. A. T. et al. A mouse model of familial hypertrophic cardiomyopathy. Science 272, 731-734 (1996).

183. Sambrock, J., Fritsch, E. F., & Maniatis, T. Molecular cloning: a laboratory manual (1989).

184. Ausubel, F. M. et al. Current protocols in molecular biology (1987).

185. Riethmacher, D., Brinkmann, V., & Birchmeier, C. A Targeted Mutation in the Mouse E-Cadherin Gene Results in Defective Preimplantation Development. Proceedings of the National Academy of Sciences of the United States of America 92, 855-859 (1995).

186. Hooper, M., Hardy, K., Handyside, A., Hunter, S., & Monk, M. Hprt-Deficient (Lesch-Nyhan) Mouse Embryos Derived from Germline Colonization by Cultured-Cells. Nature 326, 292-295 (1987).

187. Kuhn, R., Rajewsky, K., & Muller, W. Generation and Analysis of Interleukin-4 Deficient Mice. Science 254, 707-710 (1991).

188. Ramirez-Solis, R. et al. Genomic Dna Microextraction - A Method to Screen Numerous Samples. Analytical Biochemistry 201, 331-335 (1992).

189. Huelsken, J. et al. Requirement for beta-catenin in anterior-posterior axis formation in mi. Journal of Cell Biology 148, 567-578 (2000).

190. Borrmann, C. M. et al. Molecular diversity of plaques of epithelial-adhering junctions. Epithelial Transport and Barrier Function 915, 144-150 (2000).

191. Schmelz, M., Duden, R., Cowin, P., & Franke, W. W. A Constitutive Transmembrane Glycoprotein of Mr-165000 (Desmoglein) in Epidermal and Non-Epidermal Desmosomes .1. Biochemical-Identification of the Polypeptide. European Journal of Cell Biology 42, 177-183 (1986).

192. Nuber, U. A., Schafer, S., Stehr, S., Rackwitz, H. R., & Franke, W. W. Patterns of desmocollin synthesis in human epithelia: Immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. European Journal of Cell Biology 71, 1-13 (1996).

193. Schäfer, S., Stumpp, S., & Franke, W. W. Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues. Differentiation 60, 99-108 (1996).

194. Kurzen, H. et al. Compositionally different desmosomes in the various compartments of the human hair follicle. Differentiation 63, 295-304 (1998).

195. Langbein, L. et al. Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. European Journal of Cell Biology 81, 419-435 (2002).

196. Franke, W. W., Grund, C., Osborn, M., & Weber, K. The intermediate-sized filaments in rat kangaroo PtK2 cells. I. Morphology in situ. Cytobiologie 17, 365-391 (1978).

197. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970).


© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 4.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am:
06.02.2006