[Seite 69↓]


1 Bissell, D. M., and Guzelian, P. S. 1980. Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Annals of the New York Academy of Sciences 349: 85-98.

2 Ichihara, A., Nakamura, T., Tanaka, K., Tomita, Y., Aoyama, K., Kato, S., and Shinno, H. 1980. Biochemical functions of adult rat hepatocytes in primary culture. Annals of the New York Academy of Sciences 349: 77-84.

3 Crane, L. J., and Miller, D. L. 1983. Plasma protein induction by isolated hepatocytes. Molecular and Cellular Biochemistry 53-54: 89-109.

4 Flaim, K. E., Hutson, S. M., Lloyd, C. E., Taylor, J. M., Shiman, R., and Jefferson, L. S. 1985. Direct effect of insulin on albumin gene expression in primary cultures of rat hepatocytes. American Journal of Physiology 249: E447-53.

5 Lloyd, C. E., Kalinyak, J. E., Hutson, S. M., and Jefferson, L. S. 1987. Stimulation of albumin gene transcription by insulin in primary cultures of rat hepatocytes. American Journal of Physiology 252: C205-14.

6 Michalopoulos, G., Sattler, G. L., and Pitot, H. C. 1976. Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes. Life Sciences 18: 1139-44.

7 Jefferson, D. M., Reid, L. M., Giambrone, M. A., Shafritz, D. A., and Zern, M. A. 1985. Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology 5: 14-20.

8 Nawa, K., Nakamura, T., Kumatori, A., Noda, C., and Ichihara, A. 1986. Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes. Journal of Biological Chemistry 261: 16883-8.

9 Michalopoulos, G., and Pitot, H. C. 1975. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Experimental Cell Research 94: 70-8.

10 Michalopoulos, G., Sattler, C. A., Sattler, G. L., and Pitot, H. C. 1976. Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science 193: 907-9.

11 Rojkind, M., Gatmaitan, Z., Mackensen, S., Giambrone, M. A., Ponce, P., and Reid, L. M. 1980. Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. Journal of Cell Biology 87: 255-63.

12 Spray, D. C., Fujita, M., Saez, J. C., Choi, H., Watanabe, T., Hertzberg, E., Rosenberg, L. C., and Reid, L. M. 1987. Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures. Journal of Cell Biology 105: 541-51.

13 Guguen-Guillouzo, C., Clement, B., Baffet, G., Beaumont, C., Morel-Chany, E., Glaise, D., and Guillouzo, A. 1983. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Experimental Cell Research 143: 47-54.

14 Begue, J. M., Guguen-Guillouzo, C., Pasdeloup, N., and Guillouzo, A. 1984. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology 4: 839-42.

15 Guguen-Guillouzo, C., Clement, B., Lescoat, G., Glaise, D., and Guillouzo, A. 1984. Modulation of human fetal hepatocyte survival and differentiation by interactions with a rat liver epithelial cell line. Developmental Biology 105: 211-20.

16 Clement, B., Guguen-Guillouzo, C., Campion, J. P., Glaise, D., Bourel, M., and Guillouzo, A. 1984. Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of albumin secretion and accumulation of extracellular material. Hepatology 4: 373-80.

[Seite 70↓]

17 Goulet, F., Normand, C., and Morin, O. 1988. Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes. Hepatology 8: 1010-8.

18 Fujita, M., Spray, D. C., Choi, H., Saez, J. C., Watanabe, T., Rosenberg, L. C., Hertzberg, E. L., and Reid, L. M. 1987. Glycosaminoglycans and proteoglycans induce gap junction expression and restore transcription of tissue-specific mRNAs in primary liver cultures. Hepatology 7: 1S-9S.

19 Tseng, S. C., Lee, P. C., Ells, P. F., Bissell, D. M., Smuckler, E. A., and Stern, R. 1982. Collagen production by rat hepatocytes and sinusoidal cells in primary monolayer culture. Hepatology 2: 13-8.

20 Gerlach, J. C., Ziemer, R. A., Spatkowski, G., Zeilinger, K., and Neuhaus, P. 1997. Visualization of liver sinusoidal endothelial cell repair behavior after preservation by in vitro time-lapse video microscopy. Transplantation 63: 455-9.

21 Guguen-Guillouzo, C., and Guillouzo, A. 1983. Modulation of functional activities in cultured rat hepatocytes. Molecular and Cellular Biochemistry 53-54: 35-56.

22 Ben-Ze'ev, A., Robinson, G. S., Bucher, N. L., and Farmer, S. R. 1988. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proceedings of the National Academy of Sciences of the United States of America 85: 2161-5.

23 Guguen-Guillouzo, C. 1986. Role of homotopic and heterotopic cell interactions in expression of specific functions by cultured hepatocytes. Pages 259-284 in A. Guillouzo, editors.Isolated and cultured hepatocytes. John Libbey & Co. Ltd, London, England.

24 Guillouzo, A. 1992. Hepatotoxicity. Pages 45-81 in J. Frazier, editors.In vitro toxicity testing. Applications to safety evaluation. Marcel Dekker Inc., New York, Basel, Hong-Kong.

25 Bissell, D. M., Arenson, D. M., Maher, J. J., and Roll, F. J. 1987. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. Journal of Clinical Investigation 79: 801-12.

26 Dunn, J. C., Yarmush, M. L., Koebe, H. G., and Tompkins, R. G. 1989. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB Journal 3: 174-7.

27 Dunn, J. C., Tompkins, R. G., and Yarmush, M. L. 1991. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnology Progress 7: 237-45.

28 Dunn, J. C., Tompkins, R. G., and Yarmush, M. L. 1992. Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. Journal of Cell Biology 116: 1043-53.

29 Isom, H. C., Secott, T., Georgoff, I., Woodworth, C., and Mummaw, J. 1985. Maintenance of differentiated rat hepatocytes in primary culture. Proceedings of the National Academy of Sciences of the United States of America 82: 3252-6.

30 Isom, I., Georgoff, I., Salditt-Georgieff, M., and Darnell, J. E. J. 1987. Persistence of liver-specific messenger RNA in cultured hepatocytes: different regulatory events for different genes. Journal of Cell Biology 105: 2877-85.

31 Donato, M. T., Gomez-Lechon, M. J., Jover, R., Nakamura, T., and Castell, J. V. 1998. Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. Journal of Pharmacology and Experimental Therapeutics 284: 760-7.

32 Donato, M. T., Castell, J. V., and Gomez-Lechon, M. J. 1995. Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture. Drug Metabolism and Disposition: The Biological Fate of Chemicals 23: 553-8.

33 Gomez-Lechon, M. J., Castelli, J., Guillen, I., O'Connor, E., Nakamura, T., Fabra, R., and Trullenque, R. 1995. Effects of hepatocyte growth factor on the growth and metabolism of human hepatocytes in primary culture. Hepatology 21: 1248-54.

[Seite 71↓]

34 Ohno, K., and Maier, P. 1994. Cultured rat hepatocytes adapt their cellular glycolytic activity and adenylate energy status to tissue oxygen tension: influences of extracellular matrix components, insulin and glucagon. Journal of Cellular Physiology 160: 358-66.

35 Landry, J., Bernier, D., Ouellet, C., Goyette, R., and Marceau, N. 1985. Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities. Journal of Cell Biology 101: 914-23.

36 Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB Journal 13: 1883-900.

37 Maher, J. J. 1988. Primary hepatocyte culture: is it home away from home?. Hepatology 8: 1162-6.

38 Reid, L. M., and Jefferson, D. M. 1984. Culturing hepatocytes and other differentiated cells. Hepatology 4: 548-59.

39 Neuhaus, P., Neuhaus, R., Vonnahme, F., and Pichelmayr, R. 1983. Verbesserte Möglichkeiten des temporären Leberersatzes durch ein neues Konzept der extrakorporalen Leberperfusion. in H. Schreiber, editors.Chirurgisches Forum 83 für experimentelle und klinische Forschung. Springer Verlag, Berlin, Heidelberg.

40 Neuhaus, P., and Blumhardt, G. 1993. Extracorporeal liver perfusion: applications of an improved model for experimental studies of the liver. International Journal of Artificial Organs 16: 729-39.

41 Schon, M. R., Lemmens, H. P., Neuhaus, P., Baehr, P., Heil, W., Pohlein, C., Thierry, J., and Hammer, C. 1994. Improved xenogeneic extracorporeal liver perfusion. Transplantation Proceedings 26: 1293-7.

42 Pascher, A., Sauer, I. M., Hammer, C., Gerlach, J. C., and Neuhaus, P. 2002. Extracorporeal liver perfusion as hepatic assist in acute liver failure: a review of world experience. Xenotransplantation 9: 309-24.

43 Arkadopoulos, N., Detry, O., Rozga, J., and Demetriou, A. A. 1998. Liver assist systems: state of the art. International Journal of Artificial Organs 21: 781-7.

44 Nose, Y., Mikami, J., and Kasai, Y. 1963. An experimental artificial liver utilizing extracorporeal metabolism with sliced or granulated canine liver. ASAIO Transactions 9: 358-362.

45 Brunner, G., Holloway, C. J., and Losgen, H. 1979. The application of immobilized enzymes in an artificial liver support system. Artificial Organs 3: 27-30.

46 Soyer, T., Lempinen, M., Walker, J. E., Supanwanid, P., and Eiseman, B. 1973. Extracorporeal assist of anhepatic animals with liver slice perfusion. American Journal of Surgery 126: 20-4.

47 Eiseman, B., Norton, L., and Kralios, N. C. 1976. Hepatocyte perfusion within a centrifuge. Surgery, Gynecology and Obstetrics 142: 21-8.

48 Uchino, J., Tsuburaya, T., Kumagai, F., Hase, T., Hamada, T., Komai, T., Funatsu, A., Hashimura, E., Nakamura, K., and Kon, T. 1988. A hybrid bioartificial liver composed of multiplated hepatocyte monolayers. ASAIO Transactions 34: 972-7.

49 Sussman, N. L., and Kelly, J. H. 1993. Improved liver function following treatment with an extracorporeal liver assist device. Artificial Organs 17: 27-30.

50 Ellis, A. J., Hughes, R. D., Wendon, J. A., Dunne, J., Langley, P. G., Kelly, J. H., Gislason, G. T., Sussman, N. L., and Williams, R. 1996. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology 24: 1446-51.

51 Stange, J., Mitzner, S., Strauss, M., Fischer, U., Lindemann, S., Peters, E., Holtz, M., Drewelow, B., and Schmidt, R. 1995. Primary or established liver cells for a hybrid liver? Comparison of metabolic features. ASAIO Journal 41: M310-5.

52 Gerlach, J. C., Zeilinger, K., Spatkowski, G., Hentschel, F., Schnoy, N., Kolbeck, S., Schindler, R. K., and Neuhaus, P. 2001. Large-scale isolation of sinusoidal endothelial cells from pig and human liver. Journal of Surgical Research 100: 39-45.

[Seite 72↓]

53 Gerlach, J. C. 1994. Use of hepatocyte cultures for liver support bioreactors. Advances in Experimental Medicine and Biology 368: 165-71.

54 Chapman, L. E., Folks, T. M., Salomon, D. R., Patterson, A. P., Eggerman, T. E., and Noguchi, P. D. 1995. Xenotransplantation and xenogeneic infections. New England Journal of Medicine 333: 1498-501.

55 Chapman, L. E., Heneine, W., Switzer, W., Sandstrom, P., and Folks, T. M. 1999. Xenotransplantation: the potential for xenogeneic infections. Transplantation Proceedings 31: 909-10.

56 Chapman, L. E., and Bloom, E. T. 2001. Clinical xenotransplantation. JAMA 285: 2304-6.

57 Allan, J. S., Broussard, S. R., Michaels, M. G., Starzl, T. E., Leighton, K. L., Whitehead, E. M., Comuzzie, A. G., Lanford, R. E., Leland, M. M., Switzer, W. M., and Heneine, W. 1998. Amplification of simian retroviral sequences from human recipients of baboon liver transplants. AIDS Research and Human Retroviruses 14: 821-4.

58 Blusch, J. H., Patience, C., and Martin, U. 2002. Pig endogenous retroviruses and xenotransplantation. Xenotransplantation 9: 242-51.

59 Dorling, A. 2002. Clinical xenotransplantation: pigs might fly?. American Journal of Transplantation 2: 695-700.

60 Gerlach, J. C. 1996. Development of a hybrid liver support system: a review. International Journal of Artificial Organs 19: 645-54.

61 Gerlach, J. C., Botsch, M., Kardassis, D., Lemmens, P., Schon, M., Janke, J., Puhl, G., Unger, J., Kraemer, M., Busse, B., Bohmer, C., Belal, R., Ingenlath, M., Kosan, M., Kosan, B., Sultmann, J., Patzold, A., Tietze, S., Rossaint, R., Muller, C., and Monch, 2001. Experimental evaluation of a cell module for hybrid liver support. International Journal of Artificial Organs 24: 793-8.

62 Sauer, I. M., Kardassis, D., Zeillinger, K., Pascher, A., Gruenwald, A., Pless, G., Irgang, M., Kraemer, M., Puhl, G., Frank, J., Muller, A. R., Steinmuller, T., Denner, J., Neuhaus, P., and Gerlach, J. C. 2003. Clinical extracorporeal hybrid liver support - phase I study with primary porcine liver cells. Xenotransplantation 10: 460-469.

63 Joly, A., Desjardins, J. F., Fremond, B., Desille, M., Campion, J. P., Malledant, Y., Lebreton, Y., Semana, G., Edwards-Levy, F., Levy, M. C., and Clement, B. 1997. Survival, proliferation, and functions of porcine hepatocytes encapsulated in coated alginate beads: a step toward a reliable bioartificial liver. Transplantation 63: 795-803.

64 Zeilinger, K., Sauer, I. M., Pless, G., Strobel, C., Rudzitis, J., Wang, A., Nussler, A. K., Grebe, A., Mao, L., Auth, S. H. G., Unger, J., Neuhaus, P., and Gerlach, J. C. 2002. Three-dimensional co-culture of primary human liver cells in bioreactors for in vitro drug studies: effects of the initial cell quality on the long-term maintenance of hepatocyte-specific functions. Altern Lab Anim 30: 525-38.

65 Fry, J., and Hammond, A. 1993. Assessment of the functional Integrity of Hepatocytes. Pharmacokinetics 3: 177-201

66 Callahan, A. 1967. Viability assay of tissues and organs. Cryobiology 4: 137-9.

67 Gerlach, J. C., Schnoy, N., Encke, J., Smith, M. D., Muller, C., and Neuhaus, P. 1995. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies. Hepatology 22: 546-52.

68 Gerlach, J., Schnoy, N., Smith, M. D., and Neuhaus, P. 1994. Hepatocyte culture between woven capillary networks: a microscopy study. Artificial Organs 18: 226-30.

69 Sauer, I. M., Zeilinger, K., Obermayer, N., Pless, G., Grunwald, A., Pascher, A., Mieder, T., Roth, S., Goetz, M., Kardassis, D., Mas, A., Neuhaus, P., and Gerlach, J. C. 2002. Primary human liver cells as source for modular extracorporeal liver support--a preliminary report. International Journal of Artificial Organs 25: 1001-5.

70 Herman, B., Nieminen, A. L., Gores, G. J., and Lemasters, J. J. 1988. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB Journal 2: 146-51.

[Seite 73↓]

71 Claret, M., and Mazet, J. L. 1972. Ionic fluxes and permeabilities of cell membranes in rat liver. J Physiol 223: 279-95.

72 Berry, M. N., Gregory, R. B., Grivell, A. R., Henly, D. C., Nobes, C. D., Phillips, J. W., and Wallace, P. G. 1988. Intracellular mitochondrial membrane potential as an indicator of hepatocyte energy metabolism: further evidence for thermodynamic control of metabolism. Biochimica et Biophysica Acta 936: 294-306.

73 Berry, M., Edwards, A., and Barritt, G. 1991. Assessment of integrety of isolated hepatocytes. Pages 83-98 in M. Berry, A. Edwards, and G. Barritt, editors. Isolated Hepatocytes. Elsevier, Amsterdam, New York, Oxford.

74 Buddecke, E., and Fischer, M. 1992. Enzyme. Pages 76-87 in E. Buddecke, and M. Fischer, editors. Pathophysiologie, Phatobiochemie, Klinische Chemie. Walter de Gruyter, Berlin.

75 Bircher, J. 1986. Assessment of prognosis in advanced liver disease: to score or to measure, that's the question. Hepatology 6: 1036-7.

76 Winkler, K., Bass, L., Keiding, S., and Tygstrup, N. 1979. The physiologic basis for clearance measurements in hepatology. Scandinavian Journal of Gastroenterology 14: 439-48.

77 Nyberg, S. L., Mann, H. J., Remmel, R. P., Hu, W. S., and Cerra, F. B. 1993. Pharmacokinetic analysis verifies P450 function during in vitro and in vivo application of a bioartificial liver. ASAIO Journal 39: M252-6.

78 Benowitz, N. L., and Meister, W. 1978. Clinical pharmacokinetics of lignocaine. Clinical Pharmacokinetics 3: 177-201.

79 Keenaghan, J. B., and Boyes, R. N. 1972. The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man. Journal of Pharmacology and Experimental Therapeutics 180: 454-63.

80 Bargetzi, M. J., Aoyama, T., Gonzalez, F. J., and Meyer, U. A. 1989. Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4. Clinical Pharmacology and Therapeutics 46: 521-7.

81 Gawronska-Szklarz, B., Musial, D. H., Pawlik, A., and Paprota, B. 2003. Effect of experimental diabetes on pharmacokinetic parameters of lidocaine and MEGX in rats. Polish Journal of Pharmacology 55: 619-24.

82 Mets, B., Hickman, R., and Chalton, D. 1994. Lidocaine extraction by the in vivo and isolated perfused pig liver. Journal of Hepatology 21: 1067-74.

83 Winkler, K., Henriksen, J. H., and Tygstrup, N. 1993. Hepatic, renal, and total body galactose elimination in the pig. American Journal of Physiology 265: G9-14.

84 Löffler, G., and Petrides, P. 1988. Intermediärstoffwechsel II: Kohlenhydrate. Pages 349-390 in G. Löffler, and P. Petrides, editors. Physiologische Chemie. Springer Verlag, Berlin, Heidelberg.

85 Keiding, S., Johansen, S., Winkler, K., Tonnesen, K., and Tygstrup, N. 1976. Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver. American Journal of Physiology 230: 1302-13.

86 Keiding, S., Johansen, S., and Winkler, K. 1982. Hepatic galactose elimination kinetics in the intact pig. Scandinavian Journal of Clinical and Laboratory Investigation 42: 253-9.

87 Köttgen, E., and Tauber, R. 1995. Klinisch-chemische Untersuchungen. Pages 125-145 in W. Gerok, and H. Blum, editors. Hepatologie. Urban & Schwarzenberg, München - Wien - Baltimore.

88 Bircher, J. 1983. Quantitative assessment of deranged hepatic function: a missed opportunity?. Seminars in Liver Disease 3: 275-84.

89 Shreeve, W. W., Shoop, J. D., Ott, D. G., and McInteer, B. B. 1976. Test for alcoholic cirrhosis by conversion of [14C]- or [13C]galactose to expired CO2. Gastroenterology 71: 98-101.

[Seite 74↓]

90 Zeeh, J., Lange, H., Bosch, J., Pohl, S., Loesgen, H., Eggers, R., Navasa, M., Chesta, J., and Bircher, J. 1988. Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow. Gastroenterology 95: 749-59.

91 Molino, G., Cavanna, A., Avagnina, P., Ballare, M., and Torchio, M. 1987. Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow. Digestive Diseases and Sciences 32: 753-8.

92 Molino, G., Avagnina, P., Cavanna, A., Ballare, M., Torchio, M., Bona, B., and Belforte, G. 1986. Sorbitol clearance: a parameter reflecting liver plasma flow in the rat. Research Communications in Chemical Pathology and Pharmacology 52: 119-32.

93 Andreasen, P. B., Ranek, L., Statland, B. E., and Tygstrup, N. 1974. Clearance of antipyrine-dependence of quantitative liver function. European Journal of Clinical Investigation 4: 129-34.

94 Dossing, M., Poulsen, H. E., Andreasen, P. B., and Tygstrup, N. 1982. A simple method for determination of antipyrine clearance. Clinical Pharmacology and Therapeutics 32: 392-6.

95 Engel, G., Hofmann, U., Heidemann, H., Cosme, J., and Eichelbaum, M. 1996. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clinical Pharmacology and Therapeutics 59: 613-23.

96 Gross, J. B. J., Reichen, J., Zeltner, T. B., and Zimmermann, A. 1987. The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass. Hepatology 7: 457-63.

97 Löffler, G., and Petrides, P. 1988. Intermediärstoffwechsel IV: Aminosäuren. in G. Löffler, and P. Petrides, editors. Physiologische Chemie. Springer Verlag, Berlin, Heidelberg.

98 Lehninger, A. L., Nelson, D. L., and Cox, M. M. 2000. Lehninger principles of biochemistry. Worth Publishers, New York.

99 Castell, D. O. 1965. The ammonia tolerance test: an index of portal hypertension. Gastroenterology 49: 539-43.

100 Felding, C., Christensen, R. F., and Lindahl, F. 1984. Ammonia tolerance test used to differentiate between ascites of cirrhotic and malignant genesis. Scandinavian Journal of Gastroenterology 19: 365-8.

101 Berry, M., Edwards, A., and Barritt, G. 1991. Metabolic Activities - Ureogenesis. Pages 170- 171 in M. Berry, A. Edwards, and G. Barritt, editors. Isolated Hepatocytes. Elsevier, Amsterdam, New York, Oxford.

102 Fuchs, M., Gerlach, J., Unger, J., Encke, J., Smith, M., Neuhaus, P., Nundel, M., and Riedel, E. 1994. Alpha-keto acid metabolism by hepatocytes cultured in a hybrid liver support bioreactor. International Journal of Artificial Organs 17: 554-8.

103 Fuchs, M., Gerlach, J., Encke, J., Unger, J., Smith, M., Neuhaus, P., and Riedel, E. 1994. Amino acid metabolism by hepatocytes in a hybrid liver support bioreactor. International Journal of Artificial Organs 17: 663-9.

104 Sielaff, T. D., Hu, M. Y., Rao, S., Groehler, K., Olson, D., Mann, H. J., Remmel, R. P., Shatford, R. A., Amiot, B., and Hu, W. S. 1995. A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture. Transplantation 59: 1459-63.

105 Jeejeebhoy, K. N., Phillips, M. J., Ho, J., and Bruce-Robertson, A. 1980. Ultrastructural and functional studies of cultured adult rat hepatocytes. Annals of the New York Academy of Sciences 349: 18-27.

106 Berry, M. N. 1974. High-yield preparation of morphologically intact isolated parenchymal cells from rat liver. Methods in Enzymology 32: 625-32.

107 Gerlach, J., Brombacher, J., Smith, M., and Neuhaus, P. 1996. High yield hepatocyte isolation from pig livers for investigation of hybrid liver support systems: influence of collagenase concentration and body weight. Journal of Surgical Research 62: 85-9.

[Seite 75↓]

108 Gerlach, J., Kloppel, K., Schauwecker, H. H., Tauber, R., Muller, C., and Bucherl, E. S. 1989. Use of hepatocytes in adhesion and suspension cultures for liver support bioreactors. International Journal of Artificial Organs 12: 788-92.

109 Bergmeyer, H. G. M. &. W. H. 1983. Galactose Dehydrogenase. 2: 193-194. in H. Bergmeyer, editors. Methods of Enzymatic Analysis. VCH, Weinheim, Germany - Deerfield Beach, FL, USA.

110 Bergmeyer, H. G. M. &. W. H. 1983. Sorbitol Dehydrogenase. Pages 309-310 in H. Bergmeyer, editors. Methods of Enzymatic Analysis. VCH, Weinheim, Germany - Deerfield Beach, FL, USA.

111 Brosius, F. 2002. SPSS 11. mitp Verlag, Bonn.

112 Pallant, J. 2001. SPSS Survival Manual. Open University Press, Buckingham, Philadelphia.

113 Harten, H., Nägerl, H., and Schulte, H. 1993. Statistik für Mediziner. Chapman & Hall, London, New York.

114 Eric Weisstein 2004. Eric Weisstein's World of Mathematics. http://mathworld.wolfram.com.

115 Schutz, E., Shipkova, M., Niedmann, P. D., Wieland, E., Armstrong, V. W., and Oellerich, M. 1998. Determination of monoethylglycinexylidide by fluorescence polarization immunoassay in highly icteric serum samples: modified precipitation procedure and HPLC compared. Clinical Chemistry 44: 1269-74.

116 Zeilinger, K., Tonnelier, B., Tschesche, A., Nehls, W., Spatkowski, G., Schindler, R., Riedel, E., Gerlach, Y. C., and Neuhaus, P. 1997. Effect of energy substrates on the preservation outcome of hepatocytes and sinusoidal endothelial cells in an experimental hypoxia/reoxygenation model. Transplantation Proceedings 29: 403-5.

117 Obermayer, N., Busse, B., Grunwald, A., Monch, E., Muller, C., Neuhaus, P., and Gerlach, J. C. 2001. Biochemical characterization of bioreactors for hybrid liver support: serum-free liver cell coculture of nonparenchymal and parenchymal cells. Transplantation Proceedings 33: 1930-1.

118 Meyer-Wyss, B., Renner, E., Luo, H., and Scholer, A. 1993. Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests. Journal of Hepatology 19: 133-9.

119 Farrell, G. C., Cooksley, W. G., and Powell, L. W. 1979. Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes. Clinical Pharmacology and Therapeutics 26: 483-92.

120 Meyer, B., Luo, H. S., Bargetzi, M., Renner, E. L., and Stalder, G. A. 1991. Quantitation of intrinsic drug-metabolizing capacity in human liver biopsy specimens: support for the intact-hepatocyte theory. Hepatology 13: 475-81.

121 Saad, B., Thomas, H., Schawalder, H., Waechter, F., and Maier, P. 1994. Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes. Toxicology and Applied Pharmacology 126: 372-9.

122 Le Couteur, D. G., and McLean, A. J. 1998. The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis. Clinical Pharmacokinetics 34: 359-73.

123 Jauregui, H. O., Mullon, C. J., Trenkler, D., Naik, S., Santangini, H., Press, P., Muller, T. E., and Solomon, B. A. 1995. In vivo evaluation of a hollow fiber liver assist device. Hepatology 21: 460-9.

124 Lamesch, P., Ringe, B., Oellerich, M., Burdelski, M., Beyrau, R., Gubernatis, G., and Pichlmayr, R. 1990. Assessment of liver function in the early postoperative period after liver transplantation with ICG, MEGX, and GAL tests. Transplantation Proceedings 22: 1539-41.

125 Schroeder, T. J., Gremse, D. A., Mansour, M. E., Theuerling, A. W., Brunson, M. E., Ryckman, F. C., Suchy, F. J., Penn, I., Alexander, J. W., and Pesce, A. J. 1989. Lidocaine metabolism as an index of liver function in hepatic transplant donors and recipients. Transplantation Proceedings 21: 2299-301.

126 Burdelski, M., Oellerich, M., Lamesch, P., Raude, E., Ringe, B., Neuhaus, P., Bortfeld, S., Kammerling, C., Raith, H., and Scheruhn, M. 1987. Evaluation of quantitative liver function tests in liver donors. Transplantation Proceedings 19: 3838-9.

[Seite 76↓]

127 Burdelski, M., Oellerich, M., Bornscheuer, A., Luebbe, N., Ringe, B., Lamesch, P., Raude, E., Raith, H., Scheruhn, M., and Gubernatis, G. 1989. Donor rating in human liver transplantation: correlation of oxygen consumption after revascularization with MEGX formation in donors. Transplantation Proceedings 21: 2392-3.

128 Oellerich, M., Raude, E., Burdelski, M., Schulz, M., Schmidt, F. W., Ringe, B., Lamesch, P., Pichlmayr, R., Raith, H., and Scheruhn, M. 1987. Monoethylglycinexylidide formation kinetics: a novel approach to assessment of liver function. Journal of Clinical Chemistry and Clinical Biochemistry 25: 845-53.

129 Oellerich, M., Burdelski, M., Ringe, B., Lamesch, P., Gubernatis, G., Bunzendahl, H., Pichlmayr, R., and Herrmann, H. 1989. Lignocaine metabolite formation as a measure of pre-transplant liver function. Lancet 1: 640-2.

130 Ercolani, G., Grazi, G. L., Calliva, R., Pierangeli, F., Cescon, M., Cavallari, A., and Mazziotti, A. 2000. The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery. Surgery 127: 464-71.

131 Shiffman, M. L., Luketic, V. A., Sanyal, A. J., Duckworth, P. F., Purdum, P. P. 3., Contos, M. J., Mills, A. S., Edinboro, L. E., and Poklis, A. 1994. Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis. Hepatology 19: 933-40.

132 Fabbri, A., Bianchi, G. P., and Marchesini, G. 1995. Hepatic lidocaine metabolism and liver histology. Hepatology 21: 1761-2.

133 Huang, Y. S., Lee, S. D., Deng, J. F., Wu, J. C., Lu, R. H., Lin, Y. F., Wang, Y. J., and Lo, K. J. 1993. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. Journal of Hepatology 19: 140-7.

134 Molino, G., Avagnina, P., Belforte, G., and Bircher, J. 1998. Assessment of the hepatic circulation in humans: new concepts based on evidence derived from a D-sorbitol clearance method. Journal of Laboratory and Clinical Medicine 131: 393-405.

135 Bradley, S., Ingelfinger, F., Bradley, G., and Curry, J. 1945. The estimation of hepatic blood flow in man. The Journal of Clinical Investigation 24: 890-897.

136 Bradley, S. 1962. The hapatic circulation. Pages 1387-1438 in e. American Physiologic Society, editors.Handbook of Physiology: Circulation. American Physiologic Society, Washington, DC.

137 Salganik, R. I., and Solov'eva, N. A. 1972. Induction of galactose-1-phosphate uridylyltransferase in rat liver by galactose and experimental galactosemia. Voprosy Meditsinskoi Khimii 18: 472-7.

138 Keiding, S., Andreasen, P. B., and Fauerholdt, L. 1973. Effect of phenobarbital induction on galactose elimination capacity in the rat. Biochemical Pharmacology 22: 2293-7.

139 Keiding, S., Johansen, S., and Tonnesen, K. 1977. Kinetics of ethanol inhibition of galactose elimination in perfused pig liver. Scandinavian Journal of Clinical and Laboratory Investigation 37: 487-94.

140 Bircher, J., and Colombo, J. P. 1978. Liver tests and tests of liver function. Therapeutische Umschau 35: 701-6.

141 Winkel, P., Ramsoe, K., Lyngbye, J., and Tygstrup, N. 1975. Diagnostic value of routine liver tests. Clinical Chemistry 21: 71-5.

142 Fabbri, A., Bianchi, G., Motta, E., Brizi, M., Zoli, M., and Marchesini, G. 1996. The galactose elimination capacity test: a study of the technique based on the analysis of 868 measurements. American Journal of Gastroenterology 91: 991-6.

143 Fabbri, A., Bianchi, G., Brizi, M., Zoli, M., and Marchesini, G. 1997. Uncertainty in liver function assessment on the basis of single-point galactose concentration. Digestion 58: 379-83.

144 De Bartolo, L., Jarosch-Von Schweder, G., Haverich, A., and Bader, A. 2000. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnology Progress 16: 102-8.

[Seite 77↓]

145 Mundt, A., Puhl, G., Muller, A., Sauer, I., Muller, C., Richard, R., Fotopoulou, C., Doll, R., Gabelein, G., Hohn, W., Hofbauer, R., Neuhaus, P., and Gerlach, J. 2002. A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support. International Journal of Artificial Organs 25: 542-8.

146 Sestoft, L., and Marshall, M. O. 1988. Regulation of lactate uptake and lactate production in liver from 48-h-starved rats: effects of pH, flow and glucose concentration. Clin Sci (Lond) 74: 403-6.

147 Sestoft, L., Bartels, P. D., and Folke, M. 1982. Pathophysiology of metabolic acidosis: effect of low pH on the hepatic uptake of lactate, pyruvate and alanine. Clinical Physiology 2: 51-8.

148 Munoz, A. E., Miguez, C., Rubio, M., Bartellini, M., Levi, D., Podesta, A., Niselman, V., and Terg, R. 1999. Lidocaine and monoethylglycinexylidide serum determinations to analyze liver function of cirrhotic patients after oral administration. Digestive Diseases and Sciences 44: 789-95.

149 Vessey, D. 1996. Metabolism of Xenobiotics by the Human Liver. Pages 257-306 in D. Zakim, and T. Boyer, editors.Hepatology - A textbook of Liver Disease. W.B. Saunders Company, Philadelphia.

150 Larrey, D., and Branch, R. A. 1983. Clearance by the liver: current concepts in understanding the hepatic disposition of drugs. Seminars in Liver Disease 3: 285-97.

151 Winkler, K., Keiding, S., Tonnesen, K., and Tygstrup, N. 1986. Effect of short lasting hypoxia on the metabolic function of the perfused pig liver. Comparison of ischaemic and hypoxaemic hypoxia. European Journal of Clinical Investigation 16: 106-12.

152 Kardassis, D., Busse, B., Besseling, A., Kraemer, M., Puhl, G., Spatkowski, G., Holland, G., Schnoy, N., Mueller, C., Neuhaus, P., and Gerlach, J. 1999. Enzyme release in hybrid liver support systems: marker for quality prior to clinical application. Transplantation Proceedings 31: 668-9.

153 Bader, A., De Bartolo, L., and Haverich, A. 2000. High level benzodiazepine and ammonia clearance by flat membrane bioreactors with porcine liver cells. Journal of Biotechnology 81: 95-105.

154 Pan, J., Naik, S., Santangini, H., Trenkler, D., and Jauregui, H. 1996. Flow cytometric characterization of isolated porcine hepatocyte suspensions for liver support. Artificial Organs 20: 1173-80.

155 De Bartolo, L., and Bader, A. 2002. Flat membrane bioreactor for the replacement of liver functions. Ernst Schering Res Found Workshop 89-104.

156 Rosenberg, E., Faris, R. A., Spray, D. C., Monfils, B., Abreu, S., Danishefsky, I., and Reid, L. M. 1996. Correlation of expression of connexin mRNA isoforms with degree of cellular differentiation. Cell Adhesion and Communication 4: 223-35.

157 Riordan, S. M., Skouteris, G. G., and Williams, R. 1998. Metabolic activity and clinical efficacy of animal and human hepatocytes in bioartificial support systems for acute liver failure. International Journal of Artificial Organs 21: 312-8.

158 Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V., and Schultz, P. G. 2002. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proceedings of the National Academy of Sciences of the United States of America 99: 11181-6.

159 Browne, T. R. 1990. Stable isotopes in clinical pharmacokinetic investigations. Advantages and disadvantages. Clinical Pharmacokinetics 18: 423-33.

160 Ontell, S. J., Makowka, L., Trager, J., Mazzaferro, V., Ove, P., and Starzl, T. E. 1989. Pharmacologic modulation of experimental postischemic hepatic function. Annals of Surgery 209: 200-10.

161 Maganto, P., Cienfuegos, J. A., Santamaria, L., Eroles, G., Andres, S., Castillo-Olivares, J. L., and Municio, A. M. 1988. Cryopreservation and transplantation of hepatocytes: an approach for culture and clinical application. Cryobiology 25: 311-22.

162 Maganto, P., Cienfuegos, J. A., Santamaria, L., Rodriguez, V., Eroles, G., Andres, S., Castillo-Olivares, J. L., and Municio, A. M. 1990. Auxiliary liver by transplanted frozen-thawed hepatocytes. Journal of Surgical Research 48: 24-32.

[Seite 78↓]

163 Maganto, P., Cienfuegos, J. A., Santamaria, L., Eroles, G., Andres, S., Pardo, F., Castillo-Olivares, J. L., and Municio, A. M. 1990. Transplanted frozen-thawed hepatocytes as a therapeutic approach in liver disease. Transplantation Proceedings 22: 2017-9.

164 Gerlach, J. C., Zeilinger, K., Sauer, I. M., Mieder, T., Naumann, G., Grunwald, A., Pless, G., Holland, G., Mas, A., Vienken, J., and Neuhaus, P. 2002. Extracorporeal liver support: porcine or human cell based systems?. International Journal of Artificial Organs 25: 1013-8.

165 Gerlach, J. C., and Zeilinger, K. 2002. Adult stem cell technology--prospects for cell based therapy in regenerative medicine. International Journal of Artificial Organs 25: 83-90.

166 Squinto, S. P. 1997. Genetically modified animal organs for human transplantation. World Journal of Surgery 21: 939-42.

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 3.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am: