Betrachtung der metabolischen Funktion von Hepatozyten in einem dynamischen KultursystemAndreas Grünwald1.101.1.1.1.1.11121.1.2.131.2.1.2.1.1.2.1.1.141.2.1.2.1.3.151.4.161.4.1.76#4776#4761#47169#4717111#24173#37138#4973#4570#24181.4.2.19526#5001.4.3.20101#451.4.4.70#241.4.5.211.5.1.5.1.22565#3631.5.2.1.5.3.231.5.4.1.5.5.1.6.242.252.1.2.1.1.306#2182.1.2.26585#373272.1.3.2.1.4.282.1.5.29302.2.2.2.1.312.2.2.322.2.3.332.2.4.2.3.342.3.1.170#242.3.2.35169#242.3.3.2.3.4.362.3.5.563#242.3.6.377#242.3.7.2.4.372.4.1.2.4.1.1.2.4.1.2.2.4.2.382.4.2.1.536#2722.4.2.2.399#2883.393.1.3.1.1.40577#3253.1.2.41570#3123.1.3.42585#3313.1.4.43575#3123.1.5.44570#3123.2.453.2.1.46585#3323.2.2.47585#3243.2.3.48586#3223.2.4.586#322493.3.503.3.1.586#32251288#2983.3.2.586#32252288#2983.3.3.585#33253285#2983.3.4.585#33254285#2983.4.553.4.1.370#2113.4.2.56370#2113.4.3.370#2113.4.4.57370#2113.4.5.58370#2114.594.1.4.1.1.604.1.2.614.1.3.624.1.4.4.1.5.634.2.644.2.1.4.2.2.4.2.3.4.3.65664.4.675.68 Abkürzungsverzeichnis89 Literaturverzeichnis69707172737475767778Danksagung und WidmungEidesstattliche ErklärungdeInhaltsverzeichnisHilfe Literaturverzeichnis 1 Bissell, D. M., and Guzelian, P. S. 1980. Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Annals of the New York Academy of Sciences 349: 85-98. 2 Ichihara, A., Nakamura, T., Tanaka, K., Tomita, Y., Aoyama, K., Kato, S., and Shinno, H. 1980. Biochemical functions of adult rat hepatocytes in primary culture. Annals of the New York Academy of Sciences 349: 77-84. 3 Crane, L. J., and Miller, D. L. 1983. Plasma protein induction by isolated hepatocytes. Molecular and Cellular Biochemistry 53-54: 89-109. 4 Flaim, K. E., Hutson, S. M., Lloyd, C. E., Taylor, J. M., Shiman, R., and Jefferson, L. S. 1985. Direct effect of insulin on albumin gene expression in primary cultures of rat hepatocytes. American Journal of Physiology 249: E447-53. 5 Lloyd, C. E., Kalinyak, J. E., Hutson, S. M., and Jefferson, L. S. 1987. Stimulation of albumin gene transcription by insulin in primary cultures of rat hepatocytes. American Journal of Physiology 252: C205-14. 6 Michalopoulos, G., Sattler, G. L., and Pitot, H. C. 1976. Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes. Life Sciences 18: 1139-44. 7 Jefferson, D. M., Reid, L. M., Giambrone, M. A., Shafritz, D. A., and Zern, M. A. 1985. Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology 5: 14-20. 8 Nawa, K., Nakamura, T., Kumatori, A., Noda, C., and Ichihara, A. 1986. Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes. Journal of Biological Chemistry 261: 16883-8. 9 Michalopoulos, G., and Pitot, H. C. 1975. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Experimental Cell Research 94: 70-8. 10 Michalopoulos, G., Sattler, C. A., Sattler, G. L., and Pitot, H. C. 1976. Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science 193: 907-9. 11 Rojkind, M., Gatmaitan, Z., Mackensen, S., Giambrone, M. A., Ponce, P., and Reid, L. M. 1980. Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. Journal of Cell Biology 87: 255-63. 12 Spray, D. C., Fujita, M., Saez, J. C., Choi, H., Watanabe, T., Hertzberg, E., Rosenberg, L. C., and Reid, L. M. 1987. Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures. Journal of Cell Biology 105: 541-51. 13 Guguen-Guillouzo, C., Clement, B., Baffet, G., Beaumont, C., Morel-Chany, E., Glaise, D., and Guillouzo, A. 1983. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Experimental Cell Research 143: 47-54. 14 Begue, J. M., Guguen-Guillouzo, C., Pasdeloup, N., and Guillouzo, A. 1984. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology 4: 839-42. 15 Guguen-Guillouzo, C., Clement, B., Lescoat, G., Glaise, D., and Guillouzo, A. 1984. Modulation of human fetal hepatocyte survival and differentiation by interactions with a rat liver epithelial cell line. Developmental Biology 105: 211-20. 16 Clement, B., Guguen-Guillouzo, C., Campion, J. P., Glaise, D., Bourel, M., and Guillouzo, A. 1984. Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of albumin secretion and accumulation of extracellular material. Hepatology 4: 373-80.

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