Aikawa, R.; Nawano, M.; Gu, Y.; Katagiri, H.; Asano, T.; Zhu, W.; Nagai, R. and Komuro, I. (2000): Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt, Circulation 102 [23], pp.2873-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11104747 Anneren, C. (2002): Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin, J Endocrinol 172 [1], pp.145-53. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11786382 Anneren, C.; Lindholm, C. K.; Kriz, V. and Welsh, M. (2003): The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation, Curr Mol Med 3 [4], pp.313-24. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12776987 Anneren, C.; Reedquist, K. A.; Bos, J. L. and Welsh, M. (2000): GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase, J Biol Chem 275 [37], pp.29153-61. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10878015 Anneren, C. and Welsh, M. (2000): Role of the Bsk/Iyk non-receptor tyrosine kinase for the control of growth and hormone production in RINm5F cells, Growth Factors 17 [4], pp.233-47. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10801074 Anneren, C. and Welsh, M. (2001): Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK, Mol Med 7 [5], pp.301-10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11474576 Baisse, B.; Fontolliet, C.; Bian, Y. S.; Vuilleumier, H. and Benhattar, J. (2004): Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with a focus on genetic alterations and carcinogenesis, J Clin Pathol 57 [8], pp.885-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15280414 Barker, K. T.; Jackson, L. E. and Crompton, M. R. (1997): BRK tyrosine kinase expression in a high proportion of human breast carcinomas, Oncogene 15 [7], pp.799-805. Barlat, I.; Maurier, F.; Duchesne, M.; Guitard, E.; Tocque, B. and Schweighoffer, F. (1997): A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain, J Biol Chem 272 [6], pp.3129-32. Batlle, E.; Henderson, J. T.; Beghtel, H.; van den Born, M. M.; Sancho, E.; Huls, G.; Meeldijk, J.; Robertson, J.; van de Wetering, M.; Pawson, T. and Clevers, H. (2002): Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB, Cell 111 [2], pp.251-63. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12408869 Becker, C.; Fantini, M. C.; Schramm, C.; Lehr, H. A.; Wirtz, S.; Nikolaev, A.; Burg, J.; Strand, S.; Kiesslich, R.; Huber, S.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Galle, P. R.; Blessing, M.; Rose-John, S. and Neurath, M. F. (2004): TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling, Immunity 21 [4], pp.491-501. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15485627 Berclaz, G.; Altermatt, H. J.; Rohrbach, V.; Dreher, E.; Ziemiecki, A. and Andres, A. C. (2000): Hormone-dependent nuclear localization of the tyrosine kinase iyk in the normal human breast epithelium and loss of expression during carcinogenesis, Int J Cancer 85 [6], pp.889-94.. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10709113 Berin, M. C.; McKay, D. M. and Perdue, M. H. (1999): Immune-epithelial interactions in host defense, Am J Trop Med Hyg 60 [4 Suppl], pp.16-25. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10344673 Bienz, M. and Clevers, H. (2000): Linking colorectal cancer to Wnt signaling, Cell 103 [2], pp.311-20. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11057903 Bild, A. H.; Turkson, J. and Jove, R. (2002): Cytoplasmic transport of Stat3 by receptor-mediated endocytosis, Embo J 21 [13], pp.3255-63. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12093727 Boivin, G. P.; Washington, K.; Yang, K.; Ward, J. M.; Pretlow, T. P.; Russell, R.; Besselsen, D. G.; Godfrey, V. L.; Doetschman, T.; Dove, W. F.; Pitot, H. C.; Halberg, R. B.; Itzkowitz, S. H.; Groden, J. and Coffey, R. J. (2003): Pathology of mouse models of intestinal cancer: consensus report and recommendations, Gastroenterology 124 [3], pp.762-77. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12612914 Booth, D. and Potten, C. S. (2001): Protection against mucosal injury by growth factors and cytokines, J Natl Cancer Inst Monogr [29], pp.16-20. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11694560 Brivanlou, A. H. and Darnell, J. E., Jr. (2002): Signal transduction and the control of gene expression, Science 295 [5556], pp.813-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11823631 Brown, M. T. and Cooper, J. A. (1996): Regulation, substrates and functions of src, Biochim Biophys Acta 1287 [2-3], pp.121-49. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8672527 Burgess, D.R.; Jiang, W.; Mamajiwalla, S. and Kinsey, W. (1989): Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine containing proteins and tyrosine kinase activity relative to differentiated enterocytes., J. Cell Biol. 109, pp.2139-2144. Cance, W.G.; Craven, R.J.; Bergman, M.; Xu, LiHui; Aitalo, K. and Liu, E.T. (1994): Rak, a novel nuclear tyrosine kinase expressed in epithelial cells, Cell Growth Diff. 5, pp.1347-1355. Cans, C.; Mangano, R.; Barila, D.; Neubauer, G. and Superti-Furga, G. (2000): Nuclear tyrosine phosphorylation: the beginning of a map, Biochem Pharmacol 60 [8], pp.1203-15. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11007959 Cartwright, C.A.; Mamajiwalla, S.; Skolnick, S.A.; Eckhart, W. and Burgess, D.R. (1993): Intestinal crypt cells contain higher levels of cytoskeletal-associated pp60c-src protein kinase activity than do differentiated enterocytes, Oncogene 8, pp.1033-1039. Chandrasekharan, S.; Qiu, T. ; Alkharouf, N; Brantley, K.; Mitchell, J.B. and Liu, E.T. (2002): Characterization of mice deficient in the Src family non-receptor kinase Frk/rak, Mol. Cell. Biol. 22 [14], p.In press. Chandrasekharan, S.; Qiu, T. H.; Alkharouf, N.; Brantley, K.; Mitchell, J. B. and Liu, E. T. (2002): Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak, Mol Cell Biol 22 [14], pp.5235-47. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12077350 Chang, L. and Karin, M. (2001): Mammalian MAP kinase signalling cascades, Nature 410 [6824], pp.37-40. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11242034 Chen, H. Y.; Shen, C. H.; Tsai, Y. T.; Lin, F. C.; Huang, Y. P. and Chen, R. H. (2004): Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin, Mol Cell Biol 24 [24], pp.10558-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15572663 Chen, J.; Tsang, L. L.; Ho, L. S.; Rowlands, D. K.; Gao, J. Y.; Ng, C. P.; Chung, Y. W. and Chan, H. C. (2004): Modulation of human enteric epithelial barrier and ion transport function by Peyer's patch lymphocytes, World J Gastroenterol 10 [11], pp.1594-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15162532 Cheng, L. and Lai, M. D. (2003): Aberrant crypt foci as microscopic precursors of colorectal cancer, World J Gastroenterol 9 [12], pp.2642-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14669304 Chomczynski, P. and Sacchi, N. (1987): Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem 162 [1], pp.156-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2440339 Clark, R. A. (2003): Epithelial-mesenchymal networks in wounds: a hierarchical view, J Invest Dermatol 120 [6], pp.ix-xi. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12787148 Clarke, A.R.; Gledhill, S.; Hoper, M.L.; Bird, C.C. and Wyllie, A.H. (1994): p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation, Oncogene 9, pp.1767-1773. Clevers, H. (2004): At the crossroads of inflammation and cancer, Cell 118 [6], pp.671-4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15369667 Coffer, P. J.; Jin, J. and Woodgett, J. R. (1998): Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation, Biochem J 335 ( Pt 1), pp.1-13. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9742206 Conus, N. M.; Hannan, K. M.; Cristiano, B. E.; Hemmings, B. A. and Pearson, R. B. (2002): Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase, J Biol Chem 277 [41], pp.38021-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12149249 Cooper, H. S.; Murthy, S. N.; Shah, R. S. and Sedergran, D. J. (1993): Clinicopathologic study of dextran sulfate sodium experimental murine colitis, Lab Invest 69 [2], pp.238-49. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8350599 Corpet, D. E. and Pierre, F. (2003): Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system, Cancer Epidemiol Biomarkers Prev 12 [5], pp.391-400. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12750232 Coyle, J. H.; Guzik, B. W.; Bor, Y. C.; Jin, L.; Eisner-Smerage, L.; Taylor, S. J.; Rekosh, D. and Hammarskjold, M. L. (2003): Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK, Mol Cell Biol 23 [1], pp.92-103. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12482964 Datta, S. R.; Brunet, A. and Greenberg, M. E. (1999): Cellular survival: a play in three Akts, Genes Dev 13 [22], pp.2905-27. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10579998 Datta, S. R.; Dudek, H.; Tao, X.; Masters, S.; Fu, H.; Gotoh, Y. and Greenberg, M. E. (1997): Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell 91 [2], pp.231-41. Davidson, L. A.; Lupton, J. R.; Jiang, Y. H.; Chang, W. C.; Aukema, H. M. and Chapkin, R. S. (1995): Dietary fat and fiber alter rat colonic protein kinase C isozyme expression, J Nutr 125 [1], pp.49-56. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7815176 Denegri, M.; Chiodi, I.; Corioni, M.; Cobianchi, F.; Riva, S. and Biamonti, G. (2001): Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors, Mol Biol Cell 12 [11], pp.3502-14.. hhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11694584 Dent, P.; Yacoub, A.; Fisher, P. B.; Hagan, M. P. and Grant, S. (2003): MAPK pathways in radiation responses, Oncogene 22 [37], pp.5885-96. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12947395 Derry, J. J.; Prins, G. S.; Ray, V. and Tyner, A. L. (2003): Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells, Oncogene 22 [27], pp.4212-20. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12833144 Derry, J. J.; Richard, S.; Valderrama Carvajal, H.; Ye, X.; Vasioukhin, V.; Cochrane, A. W.; Chen, T. and Tyner, A. L. (2000): Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability, Mol Cell Biol 20 [16], pp.6114-6126. Di Fruscio, M.; Chen, T. and Richard, S. (1999): Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM- 1 is a Src substrate during mitosis, Proc Natl Acad Sci U S A 96 [6], pp.2710-5. Diehl, S. and Rincon, M. (2002): The two faces of IL-6 on Th1/Th2 differentiation, Mol Immunol 39 [9], pp.531-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12431386 Dignass, A. U. (2001): Mechanisms and modulation of intestinal epithelial repair, Inflamm Bowel Dis 7 [1], pp.68-77. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11233665 Dive, C. and Hickman, J. A. (1991): Drug-target interactions: only the first step in the commitment to a programmed cell death?, Br J Cancer 64 [1], pp.192-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1854622 Easty, D. J.; Mitchell, P. J.; Patel, K.; Florenes, V. A.; Spritz, R. A. and Bennett, D. C. (1997): Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma, Int J Cancer 71 [6], pp.1061-5. Fearon, E.R. and Vogelstein, B. (1990): A genetic model for colorectal tumorigenesis, Cell 61, pp.759-767. Foss, F.M.; Veillette, A.; Sartor, O.; Rosen, N. and Bolen, J.B. (1989): Alterations in the expression of pp60c-src and p56-lck associated with butyrate-induced differentiation of human colon carcinom cells, Oncogene Res. 5, pp.13-23. Fujio, Y.; Nguyen, T.; Wencker, D.; Kitsis, R. N. and Walsh, K. (2000): Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart, Circulation 101 [6], pp.660-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10673259 Fukumoto, S.; Hsieh, C. M.; Maemura, K.; Layne, M. D.; Yet, S. F.; Lee, K. H.; Matsui, T.; Rosenzweig, A.; Taylor, W. G.; Rubin, J. S.; Perrella, M. A. and Lee, M. E. (2001): Akt participation in the Wnt signaling pathway through Dishevelled, J Biol Chem 276 [20], pp.17479-83. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11278246 Gauthier, R.; Harnois, C.; Drolet, J. F.; Reed, J. C.; Vezina, A. and Vachon, P. H. (2001): Human intestinal epithelial cell survival: differentiation state-specific control mechanisms, Am J Physiol Cell Physiol 280 [6], pp.C1540-54. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11350749 Gauthier, R.; Laprise, P.; Cardin, E.; Harnois, C.; Plourde, A.; Reed, J. C.; Vezina, A. and Vachon, P. H. (2001): Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathways, J Cell Biochem 82 [2], pp.339-55. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11527158 Gibson, S.; Tu, S.; Oyer, R.; Anderson, S. M. and Johnson, G. L. (1999): Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation, J Biol Chem 274 [25], pp.17612-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10364198 Giles, R. H.; van Es, J. H. and Clevers, H. (2003): Caught up in a Wnt storm: Wnt signaling in cancer, Biochim Biophys Acta 1653 [1], pp.1-24. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12781368 Grandori, C.; Cowley, S. M.; James, L. P. and Eisenman, R. N. (2000): The myc/max/mad network and the transcriptional control of cell behavior, Annu Rev Cell Dev Biol 16, pp.653-699. Greten, F. R.; Eckmann, L.; Greten, T. F.; Park, J. M.; Li, Z. W.; Egan, L. J.; Kagnoff, M. F. and Karin, M. (2004): IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer, Cell 118 [3], pp.285-96. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15294155 Haas-Kogan, D.; Shalev, N.; Wong, M.; Mills, G.; Yount, G. and Stokoe, D. (1998): Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC, Curr Biol 8 [21], pp.1195-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9799739 Haegebarth, A.; Heap, D.; Bie, W.; Derry, J. J.; Richard, S. and Tyner, A. L. (2004): The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2, J Biol Chem 279 [52], pp.54398-404. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15471878 Haggitt, R. C. and Reid, B. J. (1986): Hereditary gastrointestinal polyposis syndromes, Am J Surg Pathol 10 [12], pp.871-87. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3024515 Hartmann, A. M.; Nayler, O.; Schwaiger, F. W.; Obermeier, A. and Stamm, S. (1999): The interaction and colocalization of Sam68 with the splicing- associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn), Mol Biol Cell 10 [11], pp.3909-26. Harvey, A. J. and Crompton, M. R. (2003): Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation, Oncogene 22 [32], pp.5006-10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12902983 He, T. C.; Sparks, A. B.; Rago, C.; Hermeking, H.; Zawel, L.; da Costa, L. T.; Morin, P. J.; Vogelstein, B. and Kinzler, K. W. (1998): Identification of c-MYC as a target of the APC pathway, Science 281 [5382], pp.1509-12. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9727977 He, X. C.; Zhang, J.; Tong, W. G.; Tawfik, O.; Ross, J.; Scoville, D. H.; Tian, Q.; Zeng, X.; He, X.; Wiedemann, L. M.; Mishina, Y. and Li, L. (2004): BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling, Nat Genet 36 [10], pp.1117-21. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15378062 Heinrich, P. C.; Behrmann, I.; Haan, S.; Hermanns, H. M.; Muller-Newen, G. and Schaper, F. (2003): Principles of interleukin (IL)-6-type cytokine signalling and its regulation, Biochem J 374 [Pt 1], pp.1-20. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12773095 Hermiston, M. L.; Wong, M. H. and Gordon, J. I. (1996): Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system, Genes Dev 10 [8], pp.985-96. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8608945 Hinoi, T.; Yamamoto, H.; Kishida, M.; Takada, S.; Kishida, S. and Kikuchi, A. (2000): Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin Facilitates Glycogen Synthase Kinase-3beta -dependent Phosphorylation of beta -Catenin and Down-regulates beta -Catenin, J Biol Chem 275 [44], pp.34399-34406. Hocker, M. and Wiedenmann, B. (1998): Molecular mechanisms of enteroendocrine differentiation, Ann N Y Acad Sci 859, pp.160-74. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9928379 Huang, J.; Papadopoulos, N.; McKinley, A. J.; Farrington, S. M.; Curtis, L. J.; Wyllie, A. H.; Zheng, S.; Willson, J. K.; Markowitz, S. D.; Morin, P.; Kinzler, K. W.; Vogelstein, B. and Dunlop, M. G. (1996): APC mutations in colorectal tumors with mismatch repair deficiency, Proc Natl Acad Sci U S A 93 [17], pp.9049-54. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8799152 Huelsken, J. and Birchmeier, W. (2001): New aspects of Wnt signaling pathways in higher vertebrates, Curr Opin Genet Dev 11 [5], pp.547-53. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11532397 Hunter, T. (2002): Tyrosine phosphorylation in cell signaling and disease, Keio J Med 51 [2], pp.61-71. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12125907 Itzkowitz, S. H. and Yio, X. (2004): Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation, Am J Physiol Gastrointest Liver Physiol 287 [1], pp.G7-17. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15194558 Jass, J. R. (1998): Diagnosis of hereditary non-polyposis colorectal cancer, Histopathology 32 [6], pp.491-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9675586 Jemal, A.; Thomas, A.; Murray, T. and Thun, M. (2002): Cancer statistics, 2002, CA Cancer J Clin 52 [1], pp.23-47. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11814064 Kamalati, T.; Jolin, H. E.; Fry, M. J. and Crompton, M. R. (2000): Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation, Oncogene 19 [48], pp.5471-6.. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11114724 Kamalati, T.; Jolin, H. E.; Mitchell, P. J.; Barker, K. T.; Jackson, L. E.; Dean, C. J.; Page, M. J.; Gusterson, B. A. and Crompton, M. R. (1996): Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor, J Biol Chem 271 [48], pp.30956-63. Kanai, T. and Watanabe, M. (2004): [Regulatory T cells and inflammatory bowel diseases], Nihon Rinsho Meneki Gakkai Kaishi 27 [5], pp.302-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15559318 Kandel, E. S. and Hay, N. (1999): The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB, Exp Cell Res 253 [1], pp.210-29. Kau, T. R.; Way, J. C. and Silver, P. A. (2004): Nuclear transport and cancer: from mechanism to intervention, Nat Rev Cancer 4 [2], pp.106-17. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14732865 Kaufmann, S. H. and Gores, G. J. (2000): Apoptosis in cancer: cause and cure, Bioessays 22 [11], pp.1007-17. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11056477 Kennedy, S. G.; Kandel, E. S.; Cross, T. K. and Hay, N. (1999): Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria, Mol Cell Biol 19 [8], pp.5800-10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10409766 Kennedy, S. G.; Wagner, A. J.; Conzen, S. D.; Jordan, J.; Bellacosa, A.; Tsichlis, P. N. and Hay, N. (1997): The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal, Genes Dev 11 [6], pp.701-13. Kinzler, K. W.; Nilbert, M. C.; Su, L. K.; Vogelstein, B.; Bryan, T. M.; Levy, D. B.; Smith, K. J.; Preisinger, A. C.; Hedge, P.; McKechnie, D. and et al. (1991): Identification of FAP locus genes from chromosome 5q21, Science 253 [5020], pp.661-5. Kohmura, N.; Yagi, T.; Tomooka, Y.; Oyanagi, M.; Kominami, R.; Takeda, N.; Chiba, J.; Ikawa, Y. and Aizawa, S. (1994): A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption, Mol Cell Biol 14 [10], pp.6915-25. Langholz, E.; Munkholm, P.; Davidsen, M. and Binder, V. (1992): Colorectal cancer risk and mortality in patients with ulcerative colitis, Gastroenterology 103 [5], pp.1444-51. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1358741 Lasko, P. (2003): Gene regulation at the RNA layer: RNA binding proteins in intercellular signaling networks, Sci STKE 2003 [179], p.RE6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12709531 Lee, H.; Kim, M.; Lee, K. H.; Kang, K. N. and Lee, S. T. (1998): Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase, Mol Cells 8 [4], pp.401-7. Lee, J.; Wang, Z.; Luoh, S-M; Wood, W.L. and Scadden, D.T. (1994): Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene, Gene 138, pp.247-251. Lee, S. T.; Strunk, K. M. and Spritz, R. A. (1993): A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes, Oncogene 8 [12], pp.3403-10. Li, J.; Simpson, L.; Takahashi, M.; Miliaresis, C.; Myers, M. P.; Tonks, N. and Parsons, R. (1998): The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene, Cancer Res 58 [24], pp.5667-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9865719 Lin, H. S.; Berry, G. J.; Fee, W. E., Jr.; Terris, D. J. and Sun, Z. (2004): Identification of tyrosine kinases overexpressed in head and neck cancer, Arch Otolaryngol Head Neck Surg 130 [3], pp.311-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15023838 Liu, X.; Brodeur, S. R.; Gish, G.; Songyang, Z.; Cantley, L. C.; Laudano, A. P. and Pawson, T. (1993): Regulation of c-Src tyrosine kinase activity by the Src SH2 domain, Oncogene 8 [5], pp.1119-26. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7683128 Llor, X.; Serfas, M. S.; Bie, W.; Vasioukhin, V.; Polonskaia, M.; Derry, J.; Abbott, C. M. and Tyner, A. L. (1999): BRK/Sik expression in the gastrointestinal tract and in colon tumors, Clin Cancer Res 5 [7], pp.1767-77. Lowell, C. A.; Niwa, M.; Soriano, P. and Varmus, H. E. (1996): Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis, Blood 87 [5], pp.1780-1792. Lu, X. and Li, Y. (1999): Drosophila Src42A is a negative regulator of RTK signaling, Dev Biol 208 [1], pp.233-43.. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10075855 Lukong, K. E. and Richard, S. (2003): Sam68, the KH domain-containing superSTAR, Biochim Biophys Acta 1653 [2], pp.73-86. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14643926 Lynch, H. T. and de la Chapelle, A. (2003): Hereditary colorectal cancer, N Engl J Med 348 [10], pp.919-32. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12621137 Macleod, K. (2000): Tumor suppressor genes, Curr Opin Genet Dev 10 [1], pp.81-93. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10679386 Maehama, T. and Dixon, J. E. (1998): The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate, J Biol Chem 273 [22], pp.13375-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9593664 Maher, P.A. and Pasquale, E. B. (1988): Tyrosine phosphorylated proteins in different tissues during chick embryo development, J. Cell Biol. 106, pp.1747-1755. Marte, B. M. and Downward, J. (1997): PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond, Trends Biochem Sci 22 [9], pp.355-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9301337 Matsui, T.; Li, L.; del Monte, F.; Fukui, Y.; Franke, T. F.; Hajjar, R. J. and Rosenzweig, A. (1999): Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro, Circulation 100 [23], pp.2373-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10587343 Matter, N.; Herrlich, P. and Konig, H. (2002): Signal-dependent regulation of splicing via phosphorylation of Sam68, Nature 420 [6916], pp.691-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12478298 McLaren, M.; Asai, K. and Cochrane, A. (2004): A novel function for Sam68: enhancement of HIV-1 RNA 3' end processing, Rna 10 [7], pp.1119-29. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15208447 Merritt, A. J.; Allen, T. D.; Potten, C. S. and Hickman, J. A. (1997): Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation, Oncogene 14 [23], pp.2759-66. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9190891 Merritt, A. J.; Potten, C. S.; Watson, A. J.; Loh, D. Y.; Nakayama, K. and Hickman, J. A. (1995): Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia, J Cell Sci 108 ( Pt 6), pp.2261-71. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7673346 Merritt, A.J.; Potten, C.S.; Kemp, C.J.; Hickman, J.A.; Balmain, A.; Lane, D.P. and Hall, P.A. (1994): The role of p53 in spontaneous and radiation induced apapotosis in the gastrointestinal tract of normal and p53 deficient mice, Cancer Res. 5420, pp.614-617. Meyer, T.; Xu, L.; Chang, J.; Liu, E. T.; Craven, R. J. and Cance, W. G. (2003): Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase, Int J Cancer 104 [2], pp.139-46. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12569567 Mitchell, P. J.; Sara, E. A. and Crompton, M. R. (2000): A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK, Oncogene 19 [37], pp.4273-82. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010980601 Mitchell, P.J.; Barker, K.T.; Martindale, J.E.; Kamalati, T.; Lowe, P.N.; Page, M.J.; Gusterson, B.A. and Crompton, M.R. (1994): Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours., Oncogene 9, pp.2383-2390. Monteleone, G.; Trapasso, F.; Parrello, T.; Biancone, L.; Stella, A.; Iuliano, R.; Luzza, F.; Fusco, A. and Pallone, F. (1999): Bioactive IL-18 expression is up-regulated in Crohn's disease, J Immunol 163 [1], pp.143-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10384110 Moser, A. R.; Dove, W.F.; Roth, K. A. and Gordon, J.I. (1992): The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system., J. Cell Biol. 116, pp.1517-1526. Munkholm, P. (2003): Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease, Aliment Pharmacol Ther 18 Suppl 2, pp.1-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12950413 Nakamura, Y.; Nishisho, I.; Kinzler, K. W.; Vogelstein, B.; Miyoshi, Y.; Miki, Y.; Ando, H. and Horii, A. (1992): Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors, Tohoku J Exp Med 168 [2], pp.141-7. Neta, R. and Okunieff, P. (1996): Cytokine-Induced Radiation Protection and Sensitization, Semin Radiat Oncol 6 [4], pp.306-320. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10717188 Neutra, M. R. (1998): Current concepts in mucosal immunity. V Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system, Am J Physiol 274 [5 Pt 1], pp.G785-91. Nishina, H.; Fischer, K. D.; Radvanyi, L.; Shahinian, A.; Hakem, R.; Rubie, E. A.; Bernstein, A.; Mak, T. W.; Woodgett, J. R. and Penninger, J. M. (1997): Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3, Nature 385 [6614], pp.350-3. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9002521 Nucci, M. R.; Robinson, C. R.; Longo, P.; Campbell, P. and Hamilton, S. R. (1997): Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa, Hum Pathol 28 [12], pp.1396-407. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9416697 Oberg-Welsh, C.; Anneren, C. and Welsh, M. (1998): Mutation of C-terminal tyrosine residues Y497/Y504 of the Src-family member Bsk/Iyk decreases NIH3T3 cell proliferation, Growth Factors 16 [2], pp.111-24. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9932229 Oberg-Welsh, C. and Welsh, M. (1995): Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution, Gene 152 [2], pp.239-42.. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7835707 Okayasu, I.; Hatakeyama, S.; Yamada, M.; Ohkusa, T.; Inagaki, Y. and Nakaya, R. (1990): A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice, Gastroenterology 98 [3], pp.694-702. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1688816 Okayasu, I.; Ohkusa, T.; Kajiura, K.; Kanno, J. and Sakamoto, S. (1996): Promotion of colorectal neoplasia in experimental murine ulcerative colitis, Gut 39 [1], pp.87-92. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8881816 Okayasu, I.; Yamada, M.; Mikami, T.; Yoshida, T.; Kanno, J. and Ohkusa, T. (2002): Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model, J Gastroenterol Hepatol 17 [10], pp.1078-83. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12201867 Okazawa, A.; Kanai, T.; Nakamaru, K.; Sato, T.; Inoue, N.; Ogata, H.; Iwao, Y.; Ikeda, M.; Kawamura, T.; Makita, S.; Uraushihara, K.; Okamoto, R.; Yamazaki, M.; Kurimoto, M.; Ishii, H.; Watanabe, M. and Hibi, T. (2004): Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes, Clin Exp Immunol 136 [2], pp.269-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15086390 Oshima, M.; Dinchuk, J. E.; Kargman, S. L.; Oshima, H.; Hancock, B.; Kwong, E.; Trzaskos, J. M.; Evans, J. F. and Taketo, M. M. (1996): Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2), Cell 87 [5], pp.803-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8945508 Pawson, T. (1994): Signal transduction. Look at a tyrosine kinase [news; comment], Nature 372 [6508], pp.726-7. Pawson, T. (1995): Protein modules and signalling networks, Nature 373, pp.573-579. Pawson, T. and Bernstein, A. (1990): Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development., TIG 6, pp.350-356. Pawson, T. and Hunter, T. (1994): Oncogenes and cell proliferation, Current Opinion in Genetics and Development 4, pp.1-4. Pear, W. S.; Nolan, G. P.; Scott, M. L. and Baltimore, D. (1993): Production of high-titer helper-free retroviruses by transient transfection, Proc Natl Acad Sci U S A 90 [18], pp.8392-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7690960 Pedron, T.; Thibault, C. and Sansonetti, P. J. (2003): The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2, J Biol Chem 278 [36], pp.33878-86. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12813033 Pegg, A. E. (1984): Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents, Cancer Invest 2 [3], pp.223-31. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6733565 Persad, S.; Troussard, A. A.; McPhee, T. R.; Mulholland, D. J. and Dedhar, S. (2001): Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation, J Cell Biol 153 [6], pp.1161-74. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11402061 Petro, B. J.; Tan, R. C.; Tyner, A. L.; Lingen, M. W. and Watanabe, K. (2004): Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium, Oral Oncol 40 [10], pp.1040-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15509496 Philip, M.; Rowley, D. A. and Schreiber, H. (2004): Inflammation as a tumor promoter in cancer induction, Semin Cancer Biol 14 [6], pp.433-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15489136 Pinto, D.; Gregorieff, A.; Begthel, H. and Clevers, H. (2003): Canonical Wnt signals are essential for homeostasis of the intestinal epithelium, Genes Dev 17 [14], pp.1709-13. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12865297 Pizarro, T. T.; Michie, M. H.; Bentz, M.; Woraratanadharm, J.; Smith, M. F., Jr.; Foley, E.; Moskaluk, C. A.; Bickston, S. J. and Cominelli, F. (1999): IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells, J Immunol 162 [11], pp.6829-35. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10352304 Podolsky, D. K. (1999): Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense, Am J Physiol 277 [3 Pt 1], pp.G495-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10484372 Podolsky, D. K. (2002): Inflammatory bowel disease, N Engl J Med 347 [6], pp.417-29. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12167685 Polakis, P. (2000): Wnt signaling and cancer, Genes Dev 14 [15], pp.1837-51. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10921899 Pories, S. E.; Hess, D. T.; Swenson, K.; Lotz, M.; Moussa, R.; Steele, G., Jr.; Shibata, D.; Rieger-Christ, K. M. and Summerhayes, C. (1998): Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells [see comments], Gastroenterology 114 [6], pp.1287-95. Porter, E. M.; Bevins, C. L.; Ghosh, D. and Ganz, T. (2002): The multifaceted Paneth cell, Cell Mol Life Sci 59 [1], pp.156-70. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11846026 Potten, C. (1992): The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice, Cancer and Metast. Rev. 11, pp.179-195. Potten, C. S. (1990): A comprehensive study of the radiobiological response of the murine (BDF1) small intestine, Int J Radiat Biol 58 [6], pp.925-73. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1978853 Potten, C. S. (1992): The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice, Cancer Metastasis Rev 11 [2], pp.179-95. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1394796 Potten, C. S. (1997): Epithelial cell growth and differentiation. II. Intestinal apoptosis, Am J Physiol 273 [2 Pt 1], pp.G253-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9277401 Potten, C. S. (1998): Stem cells in gastrointestinal epithelium: numbers, characteristics and death, Philos Trans R Soc Lond B Biol Sci 353 [1370], pp.821-30. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9684279 Potten, C. S. (2004): Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine, Radiat Res 161 [2], pp.123-36. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14731078 Potten, C. S. and Grant, H. K. (1998): The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine, Br J Cancer 78 [8], pp.993-1003. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9792141 Potten, C. S.; Owen, G. and Booth, D. (2002): Intestinal stem cells protect their genome by selective segregation of template DNA strands, J Cell Sci 115 [Pt 11], pp.2381-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12006622 Potten, C.S. and Loeffler, M. (1990): Stem cells: attributes, cycles, spirals, pitfalls, and uncertainties. Lessons for and from the crypt, Development 110, pp.1001-1020. Qiu, H. and Miller, W. T. (2002): Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition, J Biol Chem 277 [37], pp.34634-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12121988 Qiu, H. and Miller, W. T. (2004): Role of the Brk SH3 domain in substrate recognition, Oncogene 23 [12], pp.2216-23. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14676834 Quellette, A.J.; Greco, R.M.; James, M.; Frederick, D.; Naftilan, J. and Fallon, J.T. (1989): Developmental regulation of cryptin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium, J. Cell Biol. 108, pp.1687-1695. Rakoff-Nahoum, S.; Paglino, J.; Eslami-Varzaneh, F.; Edberg, S. and Medzhitov, R. (2004): Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell 118 [2], pp.229-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15260992 Rampino, N.; Yamamoto, H.; Ionov, Y.; Li, Y.; Sawai, H.; Reed, J. C. and Perucho, M. (1997): Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype, Science 275 [5302], pp.967-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9020077 Read, R. D.; Bach, E. A. and Cagan, R. L. (2004): Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways, Mol Cell Biol 24 [15], pp.6676-89. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15254235 Reddy, T. R.; Xu, W.; Mau, J. K.; Goodwin, C. D.; Suhasini, M.; Tang, H.; Frimpong, K.; Rose, D. W. and Wong-Staal, F. (1999): Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev, Nat Med 5 [6], pp.635-42. Renehan, A. G.; O'Dwyer, S. T.; Haboubi, N. J. and Potten, C. S. (2002): Early cellular events in colorectal carcinogenesis, Colorectal Dis 4 [2], pp.76-89. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12780627 Reya, T.; Duncan, A. W.; Ailles, L.; Domen, J.; Scherer, D. C.; Willert, K.; Hintz, L.; Nusse, R. and Weissman, I. L. (2003): A role for Wnt signalling in self-renewal of haematopoietic stem cells, Nature 423 [6938], pp.409-14. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12717450 Robinson, D. R.; Wu, Y. M. and Lin, S. F. (2000): The protein tyrosine kinase family of the human genome, Oncogene 19 [49], pp.5548-57. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11114734 Rogers, A. B. and Fox, J. G. (2004): Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer, Am J Physiol Gastrointest Liver Physiol 286 [3], pp.G361-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14766534 Rogler, G. and Andus, T. (1998): Cytokines in inflammatory bowel disease, World J Surg 22 [4], pp.382-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9523521 Sambrook, J.; Fritsch, E.F. and Maniatis, T. (1989): Molecular Cloning, A Laboratory Manual. Edition, Cold Spring Harbor Laboratory Press,