“Systemische Mykosen bei Patienten nach Knochenmarktransplantation und unter Intensivtherapie”Kerstin Hahlweg,2151.1671.28922.110112.22.2.12.2.212132.3143153.13.2163.2.1547#3723.2.2173.2.3183.3193.3.120427#222438#20521433#241438#2253.3.22223507#3443.4243.4.1372#18325393#2023.4.23.4.32627589#70528604#7222930604#67731604#6413.53233343.6353.6.136554#3623.6.23738554#3623.739403.8414243605#75944612#74245610#77346605#7693.94748520#34149561#29050451525354555657585960616263646566676869520#19057071 Abkürzungsverzeichnis4 Literaturverzeichnis7273747576777879808182 Danksagung83 Lebenslauf 84 Eidestattliche Erklärung 85deInhaltsverzeichnisHilfe Literaturverzeichnis 1. Anderson, K.; Morris, G.; Kennedy, H.; Croall, J.; Michie, J.; Richardson, M. D.; Gibson, B.: Aspergillosis in immunocompromised paediatric patients: associations with building hygiene, design, and indoor air.. Thorax. 1996, 51, S.256-261, 2. Ansorg, R.; van den Boom, R.; von Heinegg, E. H.; Rath, P. M.: Association between Incidence of Aspergillus Antigenemia and Exposure to Construction Works at a Hospital Site. Zentralbl Bakteriol. 1996, 284, S.146-152, 3. Arning, M.; Aul, C.: Mycose-Prophylaxe bei neutropenischen Patienten.. Mycoses. 1994, 37, Suppl. 2, S.70-76, 4. Bach, M. C.; Adler, J. L.; Breman, J.; Peng, F.; Sahyoun, A.; Schlesinger, R. M.; Madras, P.: Influence of rejection therapy on fungal and nocardial infections in renal transplant recipiens.. Lancet. 1973, 1, S.180-184, 5. Balani, S. K.: Metabolites of Caspofungin acetate, a potent antifungal agent, in human plasma and urine.. Drug Metab Dis. 2000, 28, S.1274-1278, 6. Baron, O.; Guillaume, B.; Moreau, P.; Germaud, P.; Despins, P.; De Lajartre, A. Y.; Michaud, J. L.: Aggressive surgical management in localized pulmonary mycotic and nonmycotic infections for neutropenic patients with acute leucemia: report of eighteen cases.. J Thorac Cardiovasc Surg. 1998, 115, No. 1, S.63-68, 7. Becker, M. J., de Marie, S., Willemse, D., Verbrugh, H. A., Bakker-Woudenberg, I. A. J. M.: Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model.. J Clin Microbiol. 2000, 38, S.434-1438, 8. Berger, U.; Bertozzi-Süssmann, B.; Hässner, K.; Rüchel, R.; Zimmermann, O.: Tödliche pulmonale Mischinfektion mit Aspergillus species und Candida tropicalis.. Mykosen. 1986, 30, Suppl. 2, S.39-46, 9. Bernhardt, H.; Knoke, M.; Seebacher, C.: Systemmykosen-Definition, Pathogenese und Diagnostik.. Z Klin Med (Berlin). 1986, 41, Suppl. 8, S.585-588, 10. Beyer, J.; Schwartz, G.; Barzen, G.; Risse, G.; Dullenkopf, K.; Weyer, C.; Siegert, W.: Use of amphotericin B aerosols for prevention of pulmonary aspergillosis.. Infection. 1994, 22, No. 2, S.143-147, 11. Blaschke-Hellmessen, R.: Empfehlungen für die mykologische Diagnostik.. Arbeitsmappe. 1990 S.S. 14 ff., 12. Blechschmidt, J.; Meinhof, W.: Candida-Mykosen in der Praxis. Diagnostik und Therapie.. Diebach Verlag, Berlin, 1989 S.69, 13. Bodey, G. P.: The emergence of fungi as major hospital pathogens. J. Hosp.. Infect.. 1988, 11, S.411-426, 14. Bodey, G. P.; Vartivarian, S.: Aspergillosis.. Eur J Clin Microbiol Infect Dis. 1989, 8, Suppl. 5, S.413-437, 15. Bodey, G. P.; Buckley, M.; Sathe, Y. S. et al.: Quantitative relationships between circulating leucocytes and infections in patients with akute leukemia.. Ann Internal Med. 1966, 64, S.328-340,

16. Bodey, G. P.; Bolivar, R.; Fainstein, V.: Infectious complications in leucemic patients.. Hematologia. 1982, 19, S.193-226, 17. Bowden, R. A.; Cays, M.; Gooley, T.; Mamelok, R. D.; van Burik, J. A.: Phase I study of amphotericin B colloidal dispersion for the treatment of invasive fungal infections after marrow transplant.. J Infect Dis. 1996, 173, S.1208-1215, 18. Brandl, M.; Rettig, M.; Seibt, J.: Bedeutung einheimischer Mykosen für die Intensivmedizin.. Z Diagnost Ther Pflege. 1984, 1, S.27-35, 19. Bretagne, S.; Bart-Delabesse, E.; Wechsler, J.; Kuentz, M.; Dhedin, N.; Cordonnier, C.: Fatal primary cutaneous aspergillosis in a bone marrow transplant recipient: nosocomial acquisition in a laminar-air flow room.. J Hosp Infect. 1997, 36,, S.235-239, 20. Bretagne; S.; Marmorat-Khuong, A.; Kuentz, M.; Latge, J. P.; Bart-Delabesse, E.; Cordonnier, C.: Serum Aspergillus galactomannan antigen testing by sandwich ELISA: practical use in neutropenic patients.. J Infect. 1997, 35, Suppl. 1, S.7-15, 21. Brown, R. S. Jr.; Lake, J. R.; Katzmann, B. A.; Ascher, N. L.; Somberg, K. A.; Emond, J. C.; Roberts, J. P.: Incidence and significance of Aspergillus cultures following liver and kidney transplantation.. Transplantation. 1996, 61, No. 4 22. Burnie, J. P.; Williams, J. D.: Evaluation of the Ramco latex agglutination test in the early diagnosis of systemic candidiasis.. Eur J Clin Microbiol. 1985, 4, 2, S.98-102, 23. Cabezudo, I.; Pfaller, M.; Gerarden, T.; Koontz, F.; Wenzel, R.; Gingrich, R.; Heckmann, K.; Burns, C. P.: Value of the Cand-Tec Candida antigen assay in the diagnosis and therapy of systemic candidiasis in high-risk patients.. Eur J Clin Microbiol Infect Dis. 1989, 8, S.770-777, 24. Carliste, P. S.; Gucalp, R.; Wiernik, P. H.: .: Nosocomial infections in neutropenic cancer patients.. Infect Control Hosp Epidemiol. 1993, 14, S.320-324, 25. Castagnola, E.; Bucci, B.; Montinaro, E.; Viscoli, C.: .: Fungal infections in patients undergoing bone marrow transplantation: an approach to a rational management protocol.. Bone Marrow Transplant. 1996, 18, Suppl. 2, S.97-106, 26. Chandrasekar, P. H.; Gatny, C. M.: . : The effect of fluconazole prophylaxis on fungal colonization in neutropenic cancer patients.. J Antimicrob Chemother. 1994, 33, Suppl. 2, S.309-318, 27. Chiller, T., Farrokhshad, K., Brummer, E., Stevens, D. A.: .: Influence of human sera on the in vitro activity of the Echinocandin Caspofungin (MK-0991) against Aspergillus fumigatus.. Antimicrob Agents Chemother. 2000, 44, S.3302-3305, 28. Conneally, E.; Cafferkey, M. T.; Daly, P. A.; Keane, C. T.; Mc Cann, S. R.: Nebulized amphotericin B as prophylaxis against invasive aspergillosis in granulocytopenic patients.. Bone Marrow Transplant. 1990, 5, Suppl. 6, S.403-406, 29. Costabel, U.; Billmann, P.; Schaefer, H.-E.; Guzman, J.; Kappe, R.; Müller, J.: .: Invasive und granulomatöse Aspergillus-Pneumonie mit zerebralen Streuherden.. Mykosen. 30, Suppl. 2, S.29-38, 30. De Bock, R.: Epidemiology of invasive fungal infections in bone marrow transplantation.. Bone Marrow Transplantation. 1994, 14, Suppl. 5, S.1-2,

31. De Lozier, J. B.: Rapid diagnosis of Candida sepsis in surgical patients.. Am Surg. 1987, 53, 10 , S.600-602, 32. De Witt, S.; Clumbeck, N.: Fluconazole in the treatment of fungal infections assoziated with AIDS.. Infection. 1989, 17, S.121-123, 33. Denning, D. W.: Handbuch der opportunistischen Pilzinfektionen.. Science Press. 1994, S.1-71, 34. Caspofungin. http://www.doctorfungus.org/thedrugs/Caspo-fungin.htm. 35. Edwards, J. E.; Bodey, G. P.; Bowden, R. A.; Buchner, T.; de Pauw, B. E.; Filler, S. G.: : International Conference for the Development of a Consensus on the Managment and Prevention of Severe Candidal Infections.. Clin Infect Dis. 1997, Suppl. 1, S.43-59, 36. Einsele, H., Quabeck, K., Müller, K.-D., Hebart, H., Rotenhöfer, I., Löffler, J., Schaefer, U. W.: Prediction of invasive colonisation of lower respiratory tract before marrow transplantation.. Lancet. 1998, 352, S.1443, 37. Epstein, J. B.; Ransier, A.; Lunn, R.; Chin, E.; Jacobson, J. J.; Le, N.; Reece, D.: Prophylaxis of candidiasis in patients with leucemia and bone marrow transplants.. Oral Surg Oral Med Oral Pathol. 1996, 8, S.291-295, 38. Ernst, E. J., Klepser, M. E., Pfaller, M. A.: Postfunginal effects of Echino-candin, Azole and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.. Antimicrob Agents Chemother. 2000, 44, S.1108-1111, 39. Fegeler, W.: Epidemiologie und Pathogenese generalisierter einheimischer Mykosen;. in: Systemische Mykosen. Editiones Roche, S.pp. 19-35,, 40. Fegeler, W.: Diagnostik und Frühdiagnostik von System- und Organmykosen.. In: Organmykosen. Aktuelles zur Klinik, Diagnostik und Therapie.. Verlag Stuttgart, 1989 S.4-8, 41. Fegeler, W.; Macher, W.; Nolting, S.: Tierexperimentelle Untersuchungen zur Immunität bei der Infektion mit Candida albicans.. Mykosen. 1987, 21, S.201-222, 42. Fegeler, W.; Kappe, R.; Müller, J.; Müller, H.-L.: Diagnostisches Vorgehen bei Verdacht auf Endomykosen.. Editiones „Roche“. 1990 S.3-27, 43. Fortun, J., Martin-Davila, P., Alvarez, M. E., Sanchez-Sousa, A., Quereda, C., Navas, E., Barcena, R., Vicente, E., Candelas, A., Honrubia, A., Nuno, J., Pintado, V., Moreno, S.: Aspergillus antigenemia sandwich-enzyme immunoassay test as a serodiagnostic method for invasive aspergillosis in liver transplant recipients.. Transplantation. 2001, 71, S.145-149, 44. Fortun, J.; Lopez-San Roman, A.; Velasco, J. J.; Sanchez-Sousa, A.; de Vicente, E.; Nuno, J.; Quereda, C.; Barcena, R.; Monge, G.; Candela, A.; Honrubia, A.; Guerrero, A.: Selection of Candida glabrata strains with reduced susceptibility to azoles in four liver transplant patients with invasive candidiasis.. Eur J Clin Microbiol Infect Dis. 1997, 16, S.314-318, 45. Fung, J. C.; Donta, S. T.; Tilton, R. C.: Candida detection system (CAND- TEC) to differentiate between Candida albicans colonization and disease.. J Clin Microbiol. 1986, 24, 4, S.542-547, 46. Galgiani, J. N.: Fluconazole, a new antifungal agent.. Ann Int Med. 1990, 113, S.177-179, 47. Gaya, H.; Tattersall, H. N.; Hutchinson, R. M.; Spiers, A. S.: Changing patterns of infection in cancer patients.. Eur J Cancer. 1973, 9, S.401-404, 48. Gemeinhardt, H.: Endomykosen: Schleimhaut-, Organ- und Systemmykosen..

Jena

, Gustav Fischer Verlag,, 1989 S.510 S., 49. Gentry, L. O.; Wilkinson, I. D.; Lea, A. S.; Price, M. F.: Latex agglutination test for detection of Candida antigen in patients with disseminated disease.. Eur J Clin Microbiol. 1983, 2, 2, S.122-128, 50. Gentry, L. O.; Zeluff, B. J.: Nosocomial and other difficult infections in the immunocompromised cardiac transplant patient.. J Hosp Infect. 1988, 11, Suppl. A, S.21-28, 51. Giamarellou, H.; Antoniadou, A.: Epidemiology, diagnosis, and therapy of fungal infections in surgery.. Infect Control Hosp Epidemiol. 1996, 17, Suppl. 8, S.558-564, 52. Glasmacher, A.; Marklein, G.; Just-Nübling, G.; Leutner, C.; Ewig, S.: Diagnostik invasiver Mycosen bei neutropenischen Patienten mit hämatologischen Systemerkrankungen.. DMW. 1998, Nr. 6,, S.157-160, 53. Gotzinger, P.; Sautner, T.; Wamser, P.; Gebhard, B.; Barlan, M.; Steininger, R.; Fugger, R.; Muhlbacher, F.: Frühe postoperative Infektionen nach Lebertransplantation- Keimspektrum und Risikofaktoren.. Klin Wochenschr. 1996, 108, No. 23, S.795-801, 54. Gugel, A., Finke, J., Bertz, H., Herrmann, J.: Aspergillus-Antigen ELISA im Vergleich mit klinisch-laborchemischen Verlaufsparametern bei Patienten mit invasiver Aspergillose.. 50. Kongreß der DGHM und 25. Jahrestagung der DGI,.

Berlin

, 4.-9. Oktober 1998, 55. Günther, I.: Ergebnisse der selektiven Dekontamination des Verdauungstraktes.. Dissertationsschrift.

Universität Rostock

, 1985 56. Hadley, S.; Karchmer, A. W.: Fungal infections in solid organ transplant recipients.. Infect Dis Clin North Am. 1995, 9, S.1045-1074, 57. Hammarstrom, L.: Prophylaxis of Candida infections in transplanted patients.. Acta Paediatr. 1995, 84, Suppl. 4, S.463-464, 58. Hantschke, D.: Die Bedeutung zentraler Venenkatheter bei der Entstehung von Candida-Endomykosen.. Mycoses Berlin (W.). 1989, 32, S.235-238, 59. Hantschke, D.; Olbricht, I.: Häufigkeit des Sproßpilznachweises im Urin in Abhängigkeit von der Sproßpilzkeimzahl im Stuhl bei antibakteriell und nicht antibakteriell behandelten Kindern.. Mykosen-Berlin (W.). 1989, 19, S.12-18, 60. Hebart, H., Löffler, J., Meisner, C., Serey, F., Schmidt, D., Böhme, A., Martin, H., Engel, A., Bunjes, D., Kern W. V., Schumacher, U., Kanz, L., Einsele, H.: Early detection of Aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening.. J Infect Dis. 2000, 181, S.1713-1719, 61. Heidemann, H.: Prevention of amphotericin B nephrotoxity; The effects of salt loading and flucytosine.. Mycoses. 1988, 31, Suppl. 2, S.39-44, 62. Hibberd, P. L.; Rubin, R. H.: Clinical aspects of fungal infection in organ transplant recipients.. Clin Infect Dis. 1994, 19, Suppl. 1, S.33-40, 63. Höffken, G.: Fungal infections during neutropenia; The role of prophylaxis.. mycoses. 1989, 32, Suppl. 1, S.88-95, 64. Hoppe, J. E.; Klingebiel, M. D.; Niethammer, D.: Selection of Candida glabrata in paediatric bone marrow transplant recipients receiving Fluconazole.. Paediatr Hematol Oncol. 1994, 11, S.207-210, 65. Hoppe, J. E.; Klingebiel, T.; Niethammer, D.: Orointestinale Sproßpilzbesiedelung bei pädiatrischen Knochenmarktransplantationspatienten: Überwachung mittels quantitativer Kultur und Serologie.. Mycoses. 1995, 38, S.51-57, 66. Hoppe, J. E.; Klausner, M.; Klingebiel, T.; Niethammer, D.: Retrospective analysis of yeast colonization and infections in paediatric bone marrow transplant recipients.. Mycoses. 1997, 40, Suppl. 1-2, S.47-54, 67. Hopwood, V.; Johnson, E. M.; Cornish, J. M.; Food, A. B.; Evans, E. G.; Warnock, D. W.: Use of the Pastorex aspergillus antigen latex agglutination test for the diagnosis of invasive aspergillosis.. J Clin Pathol. 1995, 48, S.210-213, 68. Horn, L. C.; Nenoff, P.; Mierzwa, M.; Schwenke, H.; Friedrich,T.; Haustein, U. F.: Epidemiologie und Diagnostik invasiver Schimmelpilzinfektionen bei immunsupprimierten Patienten: Ergebnisse einer 3-Jahres-Studie der Leipziger Universität.. Verh Dtsch Ges Pathol. 1996, 80, S.337, 69. Jackson, A., C; Pharm. D.; William, E.: Oral azole drugs as systemic antifugal therapy.. N Engl J Med. 1994, 330, S.263-270, 70. Jandrlic, M.; Kalenic, S.; Labar, B.; Nemet, D.; Jakic-Razumovic, J.; Mrsic, M.; Plecko, V.; Bogdanic, V.: An autopsy study of systemic fungal infections in patients with hematologic malignancies.. Eur J Clin Micobiol Infect Dis. 1995, 14, S.768-774, 71. Jantunen, E., Ruutu, P., Piilonen, A., Volin, L., Parkkali, T., Ruutu, T.: Treat-ment and outcome of invasive Aspergillus infections in allogenic BMT reci-pients.. Bone Marrow Transplant. 2000, 26, S.759-762, 72. Jantunen, E.; Ruutu, P.; Niskanen, L.; Volin, L.; Parkkali, T.; Koukila-Kahkola, P.; Ruutu, T.: Incidence and risk factors for invasive fungal infections in allogeneic BMT recipients.. Bone Marrow Transplant. 1997, 19, Suppl. 8, S.801-808, 73. Jehn, U.: Antiinfektiöse Therapie in der Hämatologie und Onkologie. Antimykotische Therapie.. Symposium,. 1990 S.55-61, 74. Kaben, U.; Westphal, H.-J.; Günther, I.: Mykologische Probleme bei Patienten mit reduzierter Infektabwehr.. Z Klin Med. 1986, 41, Suppl. 10, S.739-742, 75. Kahn, F. W.; Jones, J. M.: Latex agglutination tests for detection of Candida antigens in sera of patients with invasive candidiasis.. Infect Dis. 1986, 153, S.579-583, 76. Kaiser, L.; Rochat, T .: .: Aspergillus lung pathology in transplant patients.. Rev Mal Respir. 1996, 13, Suppl. 5, S.93-101, 77. Kappe, R.; Müller, J.: Tieflokalisierte Mykosen- Klinik, Pathologie, Labordiagnostik und Therapie in Falldarstellungen.. Mycoses. 1987, 30, Suppl. 2, S.1-108, 78. Kehrer, E.; Brandt, G.: Mykosen im Autopsiematerial: Häufigkeit, Lokalisationen und Ursachenspektrum.. Mykosen. 1979, 22, Suppl. 8, S.280-288, 79. Klastersky, J.; Zinner, S. H.; Calandra, T.: Empiric Antimicrobial Therapy for Febrile Granulozytopenic Cancer Patients:. Lessons from Four EORTC Trials Oncol. Suppl. 1, 1988 S.535-545, 80. Klingspor, L.; Stintzing, G.; Fasth, A.; Tollemar, J.: Deep Candida infection in children receiving allogenic bone marrow transplants: incidence, risk factors and diagnosis.. Bone Marrow Transplant. 1996, 17, Suppl. 6, S.1043-1049,

81. Kostiala, I.; Elonen, E.; Ylipaavalniemi, P.: Prospective study on humoral immune response induced by fungal infection in patients with hematologic malignancies.. Infection. 1986, 14, S.255-260, 82. Krisch, H.; Scernow, E.: Sammlungen von Kasuistiken im Rahmen der klinischen Erprobung von Fluconazol in Deutschland.. Mycoses. 1990, 33, Suppl. 1, S.14-18, 83. Kroschinsky, F., Naumann, R., Ehninger, G.: Candida-Mykosen in der Hämatologie/Onkologie, Aspekte zur Epidemiologie, Diagnostik, Prophylaxe und Therapie.. Mycoses. 1999, 42,, Suppl.1 S.53-59, 84. Lajonchere, J. P.; Feuilhade de Chauvin, M.: Contamination by aspergillosis: evaluation of preventive measures and monitoring of the environment.. Path Biol. 1994, 42, No. 7, S.718-729, 85. Lam, H. H.; Althaus, B. L.: Antifugal prophylaxis in bone marrow transplant.. The Annals of Pharmacotherapy. 1995, Vol. 29,, S.921-924, 86. Lemieux, C.; St- Germain, G.; Vincelette, J.; Kaufmann, L.; de Repentigny, L.: Collaborative evaluation of antigen detection by a commercial latex agglutination test and enzyme immunoassay in the diagnosis of invasive candidiasis.. J Clin Microbiol. 1990, 28, S.249-253, 87. Lortholary, O; Dupont, B.: Antifungal prophylaxis during neutropenia and immunodeficiency.. Clin Microbiol Rev. 1997, 10, S.477-504, 88. Machetti, M., Feasi, M., Mordini, N., van Lint, M. T., Bacigalupo, A., Latge, J. P., Sarfati, J., Viscoli, C.: Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipients.. Bone Marrow Transplant. 1998, 21, S.917-921, 89. Maertens, J., Verhaegen, J., Demuynck, H., van Eldere, J., Verbist, L., Boogaerts, M.: Serial monitoring of circulating galactomannan in the early diagnosis of invasive aspergillosis: results of a prospective, autopsy-control-led study in haematological patients. Abstracts (J-43) of the 38th ICAAC, September 24-27,.

San Diego, California.

Annual Meeting of the Ame-rican Society of Microbiology.

, 1998 90. Mariott, S. M.; Richardson, K.: The discovery and mode of action of fluconazole.. In: Fromtling, R. A. (ed) Recent Trends in the Discovery, Developmentand Evaluation of Antifungal Agents..

Barcelona

, : J. R. Prous Science Publishers, 1987 S.pp. 81-92, 91. Marmorat-Khuong, A, Bretagne S, Cordonnier, C., Houin, R.: Detection of Aspergillus galactomannan by ELISA.. Abstract, 2nd meeting of the European Confederation of Medical Mycology (ECMM),.

Congress Centre Brussels, Belgium

, 1995 92. Marr, K. A.; White, T. C.; van Burik, J. A.; Bowden, R. A.: Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation.. Clin Infect Dis. 1997, 25, Suppl. 4, S.908-910, 93. Maschmeyer, G.; Link, H.; Hiddemann, W.; Meyer, P.; Helmerking, M.; Adam, D.: For the International Antimicrobial Strategy Study Group of the Paul Ehrlich Society for Chemotherapy; Interventional Antimicrobial Strategy in Febrile Neutropenic Patients- Results of a Multicenter Study in 1260 Patients with Hematological Malignancies.. Onkologie. 1990, 13, S.38-42, 94. Mazumdar, P. K., Marks, M. I.: Candida albicans infections in hospitalized children. A survery of predisponing factors.. Clin Pediatr. 1975, 14, S.123-129, 95. Meyers, J. D., Atkinson, K.: Infection in bone marrow transplantation.. Clin Haematol. 1983, 12, S.791-811, 96. Milliken, S. T.; Powles, R. L.: Antifungal prophylaxis in bone marrow transplantation.. Rev Infect Dis. 1990, 12, Suppl. 3, S.374-379, 97. Momin, F.; Chandrasekar, P. H.: Antimicrobial prophylaxis in bone marrow transplantation.. Ann Intern Med.. 123,

Wayne State University, Detroit, Michigan, USA

, 1995 S.205-215, 98. Morrison, V. A.; Haake, R. J.; Weisdorf, D. J.: Non-Candida fungal infections after bone marrow transplantation: risk factors and outcome.. The American Journal of Medicine. 1994, 96, S.497-502, 99. Müller, H.-L.: Serologische Diagnostik der Mykosen.. Chemotherapie. 1976, 22, Suppl. 1, S.87-102, 100. Müller, J.: Die Erregerdiagnostik der systemischen Pilzerkrankungen mit besonderer Berücksichtigung quantitativer Methoden.. Chemotherapie. 1976, 22, S.53-86, 101. Müller, J.: Immunbiological aspects of Candida mycoses- a review of electronmicroscopic studies.. Mycoses. 1978, 21, Suppl. 1, S.289-297, 102. Müller, J.: Die Labordiagnose der tieflokalisierten Candidose.. Mycoses. 1990, 33, Suppl. 1, S.7-13, 103. Müller, J.; Kappe, R.; Kubitza, D.; Feßler, R.; Scheidecker, I.: The incidence of deep-seated mycoses in Freiburg i. Br. (Federal Republic of Germany).. Mycoses. 1987, 30, Suppl. 2, S.9-28, 104. Müller, J.; Hanschke, D.: .: Diagnostische Wertigkeit der Keimzahl von Candida- und Torulopsis Arten in klinischen Untersuchungsmaterialien.. Mycoses. 1978, 21, S.122-124, 105. Myervitz, R. L.; Razin, G. J.; Allen, C. M.: Disseminated candidiasis; changes in incidense, underlying diseases and pathology.. Am J Med. 1977, 40, S.887-8, 106. Nucci, M., Biasoli, I., Akiti, T., Silveira, F., Solza, C., Barreiros, G., Spector, N., Derossi, A., Pulcheri, W.: A double-blind, randomized, placebo-control-led trial of itraconazole capsules as antifungal prophylaxis for neutropenic patients.. Clin Infect Dis. 2000, 30, S.300-305, 107. Patel, R.; Portela, D.; Badley, A. D.; Harmsen, W. S.; Larson- Keller, J. J.; Ilstrup, D. M.; Keating, M. R.; Wiesner, R. H.; Krom, R. A.; Paya, C. V.: Risk factors of invasive Candida and non-Candida fungal infections after liver transplantation.. Transplantation. 1996, 62, S.926-934, 108. Peters: Staphylokokken- eine Keimgattung kehrt zurück.. Physis. 1991, S.2-4, 109. Philips, P.; Dowd, A.; Jewesson, P.; Radigan, G.; Tweeddale, M: G.; Clarke, A.; Geere, I.; Kelly, M.: Nonvalue of antigen detection immunoassays for diagnosis of candemia.. J Clin Microbiol. 1990, 28, S.2320-2326, 110. Pizzo, P. A.; Robichaud, J.; Wesley, R.; Commers, J. R.: Fever in the Pedriatric and Young Adult Patients with Cancer.. Medicine. 1982, 61, Suppl. 3, S.153-165, 111. Pizzo, P. A.; Commers, J.; Cotton, D.; Gress, J.; Hathorn, J.; Hiemenz, J.; Longo, D.; Marschall, D.; Robichaud, K. J.: Approaching the controversies in antibacterial management of cancer patients.. Am J Med. 1984, 76, S.436-449, 112. Poirot, J. L., Isnard, F., Lesage, S., Leluan, P., Tabouret, M.: Detection by ELISA of aspergillus galactomannan in sera from hematological patients..

Lisboa,

, 1996 113. Price, M. F.; Gentry, L. O.: Incidence and significance of Candida antigen in low-risk and high-risk patient populations.. Eur J Clin Microbiol. 1986, 5, S.416-419, 114. Quabeck, K.: The lung as a critical organ in marrow transplantation.. Bone Marrow Transplant. 1994, 14, Suppl. 4, S.19-28, 115. Quabeck, K.; Müller, K. D.; Beelen, D. W.; Dermoumi, H.; Kölbel, M.; Kraft, J.; Schaefer, U. W.: Prophylaxe und Therapie von Pilz-infektionen mit Fluconazol bei Patienten nach KMT.. Mycoses. 1990, 33, Suppl. 1, S.19-25, 116. Rath, P. M.; Oeffelke, R.; Muller, K. D.; Ansorg, R.: Fragliche Aussagekraft des Nachweises von Aspergillus-Antigen in bronchoalveolären Lavagen bei Patienten nach Knochenmarktransplantation.. Mycoses. 1996, 39, S.367-370, 117. Rex, J., H.; Bennett, J. E.; Sugar, A. M.; Peter, M. D.: A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia.. N Engl J Med. 1994, 331, S.1325-1330, 118. Rieth, H.: Pilzdiagnostik- Mykosentherapie,. 7. Auflage

Melsungen

, notamed Verlag,, 1986 119. Rieth, H.: Handmykose durch Hefepilze.. Pilzdialog. 2, 1987 S.30, 120. Rimek, D., Kappe, R., Garg, A. P., Sonntag, H.-G.: PCR-Assay zur Diag-nostik invasiver Aspergillosen.. vom 4.-9. Oktober 1998, 121. Robinson, P. A.; Knirsch, A. K.; Joseph, J. A.: Fluconazole for live-treatening fungal infections in patients who cannot be treated with conventional antifungal agents.. Rev Infect Dis. 1990, 12, Suppl. 3, S.349-363, 122. Roth, C.; Gebhart, J.; Just-Nübling, G.; von Eisenhart-Rothe, B.; Beinhauer-Reeb, I.: Characterization of Amphotericin B Aerosols for Inhalation Treatment of Pulmonary Aspergillosis.. Infection. 1996, 24, No. 5, S.354-360, 123. Rousey, S. R.; Russler, S.; Gottlieb, M.; Ash, R. C.: Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogenic marrow transplantation.. Am J Med. 1991, 91, Suppl. 5, S.484-492, 124. Rüchel, R.: Diagnostik der Candidamykosen.. Internist. 1995, 36, S.125-127, 125. Rüchel, R.; Böning-Stutzer, B.; Mari, A.: A synoptical approach to the diagnosis of candidosis, relying on serological antigen and antibody tests, on culture, and on clinical data.. Mycoses. 1988, 31, S.87-106, 126. Ruchel, R.; Kern, W.: Chronic systemic aspergillosis.. Mycoses. 1997, 40, Suppl. 1, S.1, 127. Ruckdeschel, G.: Wichtige Erreger-Epidemiologie, Resistenzlage. . Antiinfektiöse Therapie in der Hämatologie und Onkologie. Symposium, Klinikum Großhadern. 1990 S.6-14, 128. Schattenberg, A.; De Vries, F.; De Witt, T.; Cohen, O.; Donelly, J. P.: Allogeneic bone marrow transplantation after partial lobectomy for aspergillosis of the lung.. Bone Marrow Transplant. 1988, 3, Suppl. 5, S.509-522, 129. Schimpff, S. C., Satterlee, W., Young, V., Serpick, A.: Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocyto-penia.. N Engl J Med. 1971, 284, S.1061, 130. Schönian, G.; Meusel, O.; Tietz, H.-J.; Meyer, W.; Gräser, Y.; Tausch, I.; Presber, W.; Mitchell, T. G.: Identification of clinical strains of Candida albicans by DNA fingerprinting with the polymerase chain reaction.. Mycoses. 1993, 36, S.171-179, 131. Schwartz, S.; Milatovic, D.; Thiel, E.: Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leucaemia.. Br J Haematol. 1997, Suppl. 3, S.663-665, 132. Schwenke, H.: Pilzinfektionen bei granulozytopenischen und immunsupprimierten Patienten.. Z gesamte Inn Med. 1992, 47, S.423-437, 133. Scroggs, M. W.; Wolfe, J. A.; Bollinger, R. R.; Sanfilippo, F.: Causes of death in renal transplant recipients: a review of autopsy findings from 1966 trough 1985.. Arch Pathol Lab Med. 1987, 111, S.983-987, 134. Seeling, M. S.: The role of antibiotics in the pathogenesis of Candida infections.. Am J Med. 1966, 40, S.887-917, 135. Seibold, M.: Labordiagnostik der Aspergillose beim abwehrgeschwächten Patienten.. In: Staib, F., Huhn, D. (Hrsg.) Pilzinfektionen bei abwehrgeschwächten Patienten.. Springer Verlag, 1991 S.17-25, 136. Selby, R.; Ramirez, C. B; Singh, R.; Kleopoulos, I.; Kusne, S.; Starzl, T. E.; Fung, J.: Brain abscess in solid organ transplant recipients receiving cyclosporine- based immunosuppression.. Arch Surg. 1997, Suppl. 3, S.304-310, 137. Shah, P. M.: Pilzinfektionen bei Organtransplantationen.. pilzdialog-München. 1989, 3, S.45-46, 138. Sulahian, A.; Tabouret, M.; Ribaud, P.; Sarfati, J.; Gluckman, E.; Latge, J. P.; Derouin, F.: Comparison of an enzyme immunoassay and latex agglutination test for detection of galactomannan in the diagnosis of invasive aspergillosis.. Eur J Clin Microbiol Infect Dis. 1996, 15, S.139-145, 139. Swanink, C. M. A., Meis, J. F. G. M., Rijs, A. J. M. M., Donnelly, J. P., Verweij, P. E.: Specifity of a sandwich enzyme-linked immunosorbent assay for detecting aspergillus galactomannan.. J Clin Microbiol. 1997, 35, S.257-260, 140. Tausch, I.; Pertschy, J.; Reinke, P.; Ziegler- Böhme, H.: Systemische Candidose bei Patienten nach Nieren- und Herztransplantation.. mycoses. 1990, 33, Suppl. 1, S.27-31, 141. Tietz, H.-J.; Schönian, G.; Schweynoch, C.: Candida glabrata: Ein Erreger im Aufwind?. hautnah derm. 1994, 10, S.552-558, 142. Tietz, H.-J.; Tausch, I.: Differenzierte Candidaserologie auf dem Prüfstand.. pilzdialog. 1993, 4, S.55-56, 143. Tietz, H.-J.; Tausch, I.; Engelmann, W.; Jänisch, W.; Döcke, W.- D.; Klug, R.: Aspergillusinfektionen in der Intensivmedizin.. hautnah mykologie-Hamburg. 1993, 3, S.58-61, 144. Troke, P. F.; Andrews, R. J.; Pye, G. W.; Richardson, K.: Fluconazole and other azoles: translation of in vitro activity to in vivo and clinical efficacy.. Rev. Infect. Dis. 1990, . 12, Suppl. 3, S.276-280, 145. van Belkum, A., Mol, W., van Saene, R., Ball, L. M., van Velzen, D., Quint, W.: PCR-mediated genotyping of Candida albicans strains from bone marrow transplant patients.. Bone Marrow Transpl. 1994, 13, S.811-815, 146. Van Cutsem, J.; Meulemans, L.; Van Gerven, F.; Stynen, D.: : Detection of circulating galactomannan by Pastorex Aspergillus in experimental invasive aspergillosis.. Mycoses. 1990, 33, Suppl. 2, S.61-69, 147. Verweij, P. E., Latge, J.-P., Rijs, A. J. M. M., Melchers, W. J. G., de Pauw, B. E., Hoogkamp-Korstanje, J. A. A., Meis, J. F. G. M.: Comparison of anti-gen detection of PCR assay using bronchoalveolar lavage fluid for diagno-sing invasive pulmonary aspergillosis in patients receiving treatment for he-matological malignancies.. J Clin Microbiol. 1995, 33, S.3150-3153, 148. Verweij, P. E., Stynen, D., Rijs, A. J. M. M., De Pauw, B. E., Hoogkamp-Korstanje, J. A. A., Meis, J. F. G. M.: Sandwich enzyme-linked immunosor-bent assay compared with pastorex latex agglutination test for diagnosing invasive aspergillosis in immunocompromised patients.. J Clin Microbiol. 1995, 33, S.1912-1914, 149. Verweij, P. E.; Dompeling, E. C.; Donnelly, J. P.; Schattenberg, A. V.; Meis, J. F.: Serial monitoring of Aspergillus antigen in the early diagnosis of invasive aspergillosis.. Infection. 1997, 25, Suppl. 2, S.86-89, 150. Villalba, R.; Gonzalez, A. I.; Linares, M. J.; Casal, M.; Torres, A.: Detection of antibodies to Candida albicans germ tube as a possible aid in diagnosing systemic candidiasis in bone marrow transplant patients.. Eur. J. Clin. Microbiol. Infect. Dis.. 1993, 12, S.347-349, 151. Viscoli, C., Machetti, M., Gazzola, P., Ricco, E., Paola, D., van Lint, M. T., Gualandi, F., Bacigalupo, A.: ELISA galactomannan antigen detection in CSF of patients with and without CNS aspergillosis.. Abstracts (J-45) of the 38th ICAAC,.

San Diego, California.

, September 24-27, 1998 152. Vogeser, M.; Haas, A.; Aust, D.; Ruckdeschel, G.: Postmortem analysis of invasive aspergillosis in a tertiary care hospital.. Eur. J. Clin. Microbiol. Infect. Dis.. 1997, 16, S.1-6, 153. von Beahr, R.; Lohmann, T.; Heym, S.; Reinke, P.; Tausch, W.; & Volk, H.- D.: Immunparalyse bei Septikämien- Labordiagnostischer Nachweis und klinische Konsequenzen.. Z Klin Med. 1990, 45, S.1133-1137, 154. von Eiff, M.; Essink, M.; Fegeler, W.; Schellong, S.; Schmidt, H.; Hiddemann, W.; Büchner, Th.; Van de Loo, J.: Klinischer Verlauf und Risikofaktoren bei Patienten mit generalisierten Mycosen.. Schweiz Med Wochenschr. 1988, 118, S.584-591, 155. Voss, A.: Eine Keimgattung kehrt zurück - Staphylokokken.. Physis spezial,. 1991, Nr. 6, Suppl. 6, S.6, 156. Warnock, D. W.: Fungal complications of transplantation: diagnosis, treatment and prevention.. J Antimicrob Chemother. 1995, 36, Suppl. B, S.73-90, 157. Weber, A.; Romig, D.: Vergleichende histologische und kulturelle Untersuchungen zum Vorkommen von Sproßpilzen in einem Obduktionsgut.. mykosen-Berlin (W.). 1982, 25, Suppl. 2, S.82-88, 158. Wegmann, T.: Rundtischdiskussion über Diagnostik und Therapie von Organmykosen,. Symposium Organmykosen,.

Erlangen

, 1986 159. Wegmann, T.: Medizinische Mykologie - ein praktischer Leitfaden..

Basel

, Editiones ROCHE,, 1988 S.260 S., 160. Willems, L., van der Gesst, R., de Beule, K.: Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodyna-mics.. J Clin Pharm Ther. 2001, 26, S.159-169, 161. Williamson E. C., Millar, M. R., Steward, C. G., Cornish, J. M., Foot, A. B. M., Oakhill, A., Pamphilon, D. H., Reeves, B., Caul, E. O., Warnock, D. W., Marks, D. I.: Infections in adults undergoing unrelated donor bone marrow transplantation.. Br J Haematol. 1999, 104, S.560-568, 162. Williamson, E. C., Leeming, J. P., Palmer, H. M., Steward, C. G., Warnock, D., Marks, D. I., Millar, M. R.: Diagnosis of invasive aspergillosis in bone marrow transplant recipients by polymerase chain reaction.. Br J Haematol. 2000, 108, S.132-139, 163. Wingard, J. R.; Merz, W. G.; Rinaldi, M. G.; Miller, C. B.; Karp, J. E., Saral, R.: Association of Turulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients.. Antimicrob. Agents Chemother.. 1993, 37, S.1847-1849, 164. Wums, J. J. Jr.; Andremont, A.; Davis, B. J.; Tancrede, C. H.; Guiguet, M.; Padhyl, A. A.; Squinazi, F.; Martone, W. J.: Pseudoepidemic of aspergillosis after development of pulmonary infiltrates in a group of bone marrow transplant patients.. J Clin Microbiol. 1987, 25, Suppl. 8, S.1459-1462,