1. Kerr,J.F. Shrinkage necrosis: a distinct mode of cellular death. J. Pathol. 105 , 13-20 (1971).

2. Linnik,M.D., Zobrist,R.H. & Hatfield,M.D. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24, 2002-2008 (1993).

3. Fink,K. et al. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation. J. Cereb. Blood Flow Metab. 18, 1071-1076 (1998).

4. Endres,M. et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J. Cereb. Blood Flow Metab. 18, 238-247 (1998).

5. Ngo,E.O., Nutter,L.M., Sura,T. & Gutierrez,P.L. Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone. Chem. Res. Toxicol. 11, 360-368 (1998).

6. Pink,J.J. et al. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem. 275, 5416-5424 (2000).

7. Asher,G., Lotem,J., Cohen,B., Sachs,L. & Shaul,Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl. Acad. Sci. U. S. A 98, 1188-1193 (2001).

8. Paganini-Hill,A. & Henderson,V.W. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140, 256-261 (1994).

9. Robinson,D., Friedman,L., Marcus,R., Tinklenberg,J. & Yesavage,J. Estrogen replacement therapy and memory in older women. J. Am. Geriatr. Soc. 42, 919-922 (1994).

10. Hurn,P.D. & Macrae,I.M. Estrogen as a neuroprotectant in stroke. J. Cereb. Blood Flow Metab. 20, 631-652 (2000).

11. Allison,D.W., Gelfand,V.I., Spector,I. & Craig,A.M. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J. Neurosci. 18, 2423-2436 (1998).

12. Furukawa,K. et al. The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J. Neurosci. 17, 8178-8186 (1997).

13. Endres,M. et al. Neuroprotective effects of gelsolin during murine stroke. J. Clin. Invest 103, 347-354 (1999).

14. Brewer,G.J. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J. Neurosci. Res. 42, 674-683 (1995).

15. Harms,C. et al. Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures. FASEB J. 14, 1814-1824 (2000).

16. Murphy,T.H., De,L.M. & Coyle,J.T. Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress. J. Neurochem. 56, 990-995 (1991).

17. Kwiatkowski,D.J. Functions of gelsolin: motility, signaling, apoptosis, cancer. Curr. Opin. Cell Biol. 11, 103-108 (1999).

18. Bubb,M.R., Senderowicz,A.M., Sausville,E.A., Duncan,K.L. & Korn,E.D. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J. Biol. Chem. 269, 14869-14871 (1994).

19. Koh,J.Y. & Choi,D.W. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 20, 83-90 (1987).

20. Prochaska,H.J. & Santamaria,A.B. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal. Biochem. 169, 328-336 (1988).

21. Murphy,T.H., So,A.P. & Vincent,S.R. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation. J. Neurochem. 70, 2156-2164 (1998).

22. Swanson,R.A. et al. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10, 290-293 (1990).

23. Harms,C. et al. Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration. J. Neurosci. 21, 2600-2609 (2001).

24. Kapinya,K.J. et al. Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. J. Neurochem. 84, 1028-1039 (2003).

25. Harms,C. et al. Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Mol. Cell Neurosci. 25, 69-82 (2004).

26. Raina,A.K., Templeton,D.J., Deak,J.C., Perry,G. & Smith,M.A. Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease. Redox. Rep. 4, 23-27 (1999).

27. Wang,Y., Santa-Cruz,K., DeCarli,C. & Johnson,J.A. NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease. Neurobiol. Aging 21, 525-531 (2000).

28. Laxton,A.W., Sun,M.C., Shen,H., Murphy,T.H. & Honey,C.R. The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia. Neuroreport. 12, 1045-1048 (2001).

29. Gottron,F.J., Ying,H.S. & Choi,D.W. Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death. Mol. Cell Neurosci. 9, 159-169 (1997).

30. Murphy,T.H. et al. Preferential expression of antioxidant response element mediated gene expression in astrocytes. J. Neurochem. 76, 1670-1678 (2001).

31. Duffy,S., So,A. & Murphy,T.H. Activation of endogenous antioxidant defenses in neuronal cells prevents free radical-mediated damage. J. Neurochem. 71, 69-77 (1998).

32. Moehlenkamp,J.D. & Johnson,J.A. Activation of antioxidant/electrophile-responsive elements in IMR-32 human neuroblastoma cells. Arch. Biochem. Biophys. 363, 98-106 (1999).

33. Dinkova-Kostova,A.T. & Talalay,P. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. Free Radic. Biol. Med. 29, 231-240 (2000).

34. Li,Y. & Jaiswal,A.K. Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J. Biol. Chem. 268, 21454 (1993).

35. Prestera,T., Zhang,Y., Spencer,S.R., Wilczak,C.A. & Talalay,P. The electrophile counterattack response: protection against neoplasia and toxicity. Adv. Enzyme Regul. 33, 281-296 (1993).

36. Valerio,L.G.J., Kepa,J.K., Pickwell,G.V. & Quattrochi,L.C. Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol. Lett. 119, 49-57 (2001).

37. Ahlgren-Beckendorf,J.A., Reising,A.M., Schander,M.A., Herdler,J.W. & Johnson,J.A. Coordinate regulation of NAD(P)H:quinone oxidoreductase and glutathione-S-transferases in primary cultures of rat neurons and glia: role of the antioxidant/electrophile responsive element. Glia 25, 131-142 (1999).

38. Iwata-Ichikawa,E., Kondo,Y., Miyazaki,I., Asanuma,M. & Ogawa,N. Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis. J. Neurochem. 72, 2334-2344 (1999).

39. Campagne,M.V., Thibodeaux,H., van,B.N., Cairns,B. & Lowe,D.G. Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J. Neurosci. 20, 5200-5207 (2000).

40. Eftekharpour,E., Holmgren,A. & Juurlink,B.H. Thioredoxin reductase and glutathione synthesis is upregulated by t-butylhydroquinone in cortical astrocytes but not in cortical neurons. Glia 31, 241-248 (2000).

41. Hoult,J.R. & Paya,M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen. Pharmacol. 27, 713-722 (1996).

42. Planchon,S.M. et al. beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. Exp. Cell Res. 267, 95-106 (2001).

43. Siemankowski,L.M., Morreale,J., Butts,B.D. & Briehl,M.M. Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD(P)H:quinone reductase. Cancer Res. 60, 3638-3644 (2000).

44. Crumrine,R.C., Thomas,A.L. & Morgan,P.F. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. Cereb. Blood Flow Metab. 14, 887-891 (1994).

45. Banasiak,K.J. & Haddad,G.G. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res. 797, 295-304 (1998).

46. Culmsee,C. et al. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J. Neurochem. 77, 220-228 (2001).

47. Dubal,D.B. et al. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc. Natl. Acad. Sci. U. S. A98, 1952-1957 (2001).

48. Kahlert,S. et al. Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J. Biol. Chem. 275, 18447-18453 (2000).

49. Kothakota,S. et al. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278, 294-298 (1997).

50. Azuma,T., Koths,K., Flanagan,L. & Kwiatkowski,D. Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. J. Biol. Chem. 275, 3761-3766 (2000).

51. Koya,R.C. et al. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. 275, 15343-15349 (2000).

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 4.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am: