Der Einfluss des HIV-1 Tat-Proteins auf das Proteasom-System und die Folgen für die zelluläre ImmunabwehrXiaohua Huang111.12585#2031.23575#1411.341.451.51.6262.12.1.12.1.22.1.372.1.482.22.2.192.2.22.2.3102.2.42.2.5112.2.62.2.72.2.8122.2.92.2.102.2.11132.2.122.2.132.2.14142.2.152.2.162.2.172.2.18152.2.192.2.202.2.21162.2.2217182.2.232.2.242.2.25192.2.262.2.273203.121561#5413.222586#506233.3586#3343.424586#8333.526400#4873.627585#6213.729556#4863.830497#8953.932514#9083.103.1134586#4524354.14.2364.3374.438539 AbkürzungsverzeichnisIII Literaturverzeichnis40414243444546 Danksagung47 Lebenslauf48 Eidestattliche Erklärung49deInhaltsverzeichnisHilfe Literaturverzeichnis Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD. Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome. FEBS Lett 366, 37-42 (1995) Ahn K, Erlander M, Leturcq D, Peterson PA, Fruh K, Yang Y. 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Publikationen

Propper C, Huang X, Roth J, Sorg C, Nacken W. Analysis of the MRP8-MRP14 protein-protein interaction by the two-hybrid system suggests a prominent role of the C-terminal domain of S100 proteins in dimer formation. J Biol Chem 274 , 183-188 (1999) Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem 274 , 35297-35300 (1999) Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J 20 , 1630-1639 (2001) Pollmann C, Huang H, Mail J, Bech-Otschir D, Naumann M, Dubiel W. The Constitutive Photomorgenesis 9 Signalosome Directs Vascular Endothelial Growth Factor Production in Tumor Cells. Cancer Research 61 , 1630-1639 (2001) Huang, X, Seifert U, Salzmann U, Sijts E, Henklein, Preißner R, Henke W, Kloetzel PM, Dubiel W. The HIV-1 Tat Protein suppresses 11S regulator/PA28-dependent antigen presentation. Proc Natl Acad Sci USA , submitted