Einfluss des Pneumoperitoneums auf die Ultrastruktur des Peritoneums:Eine rasterelektronenmikroskopische Studie.Jens Jakob1.131.1.1.1.1.141.1.2.151.1.3.161718191.1.4.20211.2.1.2.1.221.2.2.23482#35624252627281.3.1.3.1.29301.3.2.3133533#2811.3.3.34352.373839492#2673.413.1.3.1.1.423.1.2.43565#5803.1.3.443.1.4.453.2.3.2.1.463.2.2.473.2.3.48493.3.504.514.1.557#4464.2.52564#456534.3.4.3.1.567#466544.3.2.562#465554.3.3.563#465564.3.4.566#456574.3.5.566#2384.3.6.566#238584.3.7.559#4654.3.8.59554#6544.4.604.5.614.6.6263644.7.65664.8.675.695.1.5.1.1.705.1.2.715.1.3.72735.2.5.2.1.74757677785.2.2.796.8182 Literaturverzeichnis83848586878889909192 Lebenslauf95 Danksagung97deInhaltsverzeichnisHilfe Literaturverzeichnis Allendorf 1995 Allendorf, J.D.F. et al.: Tumor growth after laparotomy or laparoscopy. A preliminary study. Surg Endosc . 9 (1995), S.939 - 945 Allendorf 1996 Allendort, J.D.G. et al.: Better preservation of immune function after laparoscopic - assisted vs. open bowel resection in a murine model. l Dis Colon Rectum. 1996, S.67 - 72 Andreoli 1994 Andreoli, S.P. et al. : Mechanisms of polymorphnuclear leucocyte mediated peritoneal mesothelial cell injury. Kidney International. 46 (1994), S.1100 - 1109 Aoki 1999 Aoki, Y. et al.: A model of port-site metastases of gallbladder cancer: The influence of peritoneal injury and its repair on abdominal wall metastases. Surgery. 125 (1999), S.553 - 559 Ballantyne 2002 Ballantyne GH: Robotic surgery, telerobotic surgery, telepresence, and telementoring Surg Endosc. 16 (2002), S.1389-1402 Barberini 1977 Barberini, F. et al. : Observations by scanning electron microscopy (SEM) on the surface of mesothelial cells of different peritoneal areas of the rat. Anat Anz. 142 (1977), S. 486 - 496, Basson 2000 Basson, M.D. et al.: Effect of increased ambient pressure on colon cancer cell adhesion J Cell Biochem. 78 (2000), S.47 - 61 Bedrosian 1991 Bedrosian, I. et al.: Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells. Cytokine . 3 (1991), S.568 - 575 Berci 1995 Berci, C.: Pneumoperitoneum Hrsg.: Phillips, C.H.; Rosenthal, R.J.: Operative strategies in laparoscopic surgery. 1.

Berlin

, Springer , 1995 S.13 - 18 Berends 1994 Berends FJ: Subcutaneous metastases after laparoscopic colectomy. Lancet. 344 (1994), S.58 Birbeck/Wheatley 1965 Birbeck, M.S.C.; Wheatley, D.N.: An electron microscopic study of the invasion of tumor cells in the abdominal wall Cancer Res . 25 (1965), S.490 - 497 Blenckharn 1988 Blenckharn, J.J. et al.: Sustained anti - adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyfles S). J Pharmacol. 44 (1988), S.509 - 511 Bloechle 1999 Bloechle, C. et al. : A pneumoperitoneum perpetuates severe damage to the ultrastructual integrity of parietal peritoneum in gastric perforation - induced peritonitis in rats Surg Endosc 13 (1999). 683 - 688, Böhm 1999a Böhm, B. et al.: Leber- und Nierenfunktion nach laparoskopischer und konventioneller Resektion kolorektaler Tumore - Ergebnisse aus einer prospektiv randomisierten Studie. Visceralchirurgier. 34 (1999), S.20 - 24 Bouvy 1996 Bouvy, N.C. et al.: Impact of gas(less) laparoscopy and laparotomy on peritoneal tumor growth and abdominal wall metastases. Ann Surg. 24 (1996), S.694 - 701 Braet 1997 Braet, F. et al.: Drying cells for SEM, AFM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells. J Microsc. 186 (1997), S.84 - 87 Bray 1993 Bray, D.F. et al.: Comparison of hexamethyldisilazane (HMDS), Peldri II and critical point drying methods for scanning electron microscopy. Microsc Res Technique. 26 (1993), S.489 - 495 Buck 1973 Buck, C.R.: Walker 256 tumor implantation in normal and injured peritoneum studied by electron microscopy, scanning electron microscopy and autoradiography Cancer Res. 33 (1973), S.381 - 383 Chmielnicki 1994 Chmielnicki, Z. et al.: Effect of CO2 insufflation into the peritoneal cavity on selected indices of respiratory system function during laparoscopic cholecystectomy. Wiad lec. 47 (1994), S.503 - 505 Collet 1995 Collet, D. et al.: Peritoneal host defence are less impaired by laparoscopy than by open operation. Surg Endosc. 9 (1995), 1059 - 1064, Collins 1988 Collins, R. et al.: Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic and urologic surgery N Engl J Med. 318 (1988), S.1163 - 1173 Cunningham 1994 Cunningham, A.J. et al.: Laparoscopic cholecystectomy: anesthetic implications. Anesth. Analg.. 76 (1994), S.376 - 381 Curet 2000 Curet, M.J. et al.: Laparoscopically assisted colon resection for colon carcinoma: perioperative results and long - term outcome. Surg endosc. 14 (2000), S.1062 - 1066 Daphan 1999 Daphan, C.D. et al.: Effects of laparotomy and carbon dioxide and air pneumoperitoneum on cellular immunity and peritoneal host defences in rats. Eur J Surg. 165 (1999), S.253 - 258 Dexter 1999 Dexter, S. P. et al.: Hemodynamic consequence of high- and low - pressure capnoperitoneum during laparoscopic cholecystectomy Surg endosc. 13 (1999), S.376 - 381 Dizerega/Rodgers 1992 Dizerega, G.S.; Rodgers, K.E. : The Peritoneum. 1.

New York

, 1992 S.2 - 22 Dobbie 1989 Dobbie, J.W.: Morphology of the peritoneum in CAP Blood Purif . 7 (1989), S.74 - 85 Eleftheriaids 1996 Eleftheridis, E. et al.: Splanchnic ischemia during laparoscopic CCE Surg Endosc. 10 (1996), S.324 - 326 Fernandez-Cruz 1998 Fernandez - Cruz, L. et al.: Helium and carbon dioxide pneumoperitoneum in patients with pheochronocytoma undergoing laparoscopic adrenalectomy. World J Surg. 22 (1998), S.1250 - 1255 Fleshman 1999 Fleshman, J.W. et al.: Laparoscopic vs. open abdominoperineal resection for cancer Dis Colon Rectum. 42 (1999), S.930 - 939 Franklin 1996 Franklin, M.E. et al. : Prospective comparison of open vs. laparoscopic colon surgery for carcinoma. Dis Colon Rectum. 39 (1996), S.35 - 46 Franklin 2000 Franklin, M.E. et al. : Laparoscopic surgery for stage III colon cancer: Long term follow up. Surg endosc . 14 (2000), S.612 - 616 Galizia 2001 Galizia, G. et al.: Hemodynamic and pulmonary changes during open, carbon dioxide pneumoperitoneum and abdominal wall - lifting cholecystectomy. A prospective, randomized study. Surg endosc. 15 (2001), S.477 - 483 Gebhard 2001 Gebhard, H.: Minimal invasive Chirurgie Hrsg.: Henne - Bruns, D.; Dürig, M.; Kremer, B.: Duale Reihe: Chirurgie. 1.

Stuttgart

, Georg Thieme Verlag, 2001 S.623 - 639 Goldstein 1993 Goldstein, D.S. et al.: Inhibition of peritoneal tumor cell implantation: Model for laparoscopic cancer surgery. J Endourol. 1993, 7, S.237 - 241 Guo 1993 Guo, S. et al.: Morphological response of the peritoneum and spleen to intraperitoneal biomaterials. Int J Artif Organs. 16 (1993), S.276 - 284 Gusnard/Kirschner 1977 Gusnard, D.; Kirschner, R. : Cell and organelle shrinkage during preparation for scanning electron microscopy: effects of fixation, dehydration and critical point drying. J Microsc. 110 (1977), S.51 - 57 Haney 2000 Haney, A.F.: Identification of macrophages at the site of peritoneal injury: evidence supporting a direct role for peritoneal macrophages in healing injured peritoneum Fertil Steril. 73 (2000), S.988 - 995 Hartley 2000 Hartley, J.E. et al.: Patterns of recurrence and survival after laparoscopic and conventional resections for colorectal carcinoma. Ann Surg. 232 (2000), S.181 - 186 Hazebroek 2002 Hazebroek, E.J. et al.: Impact of temperature and humidity of carbon dioxide pneumoperitoneum on body temperature and peritoneal morphology. J Laparoendosc Adv Surg Tech. 5 (2002), S.355 - 64 Henderson 1987 Henderson, I.S. et al.: Structure of the Peritoneum and changes brought by infection Contr Nephrol. 57 (1987), S.30 - 40 Henrich 1986 Henrich, M.H.: Tierexperimentelle Bariumperitonitis (Ratte, Hund) Chirurg . 57 (1986), S.801 - 804 Hyltander 2002 Hyltander A et al.: The transfer of basic skills learned in an laparoscopic simulator to the operating room. Surg endosc. 16 (2002), S.134-1329 Iwase 1993 Iwase, K. et al.: Serial Changes in renal function during laparoscopic surgery Eur Surg Res. 25 (1993), S.203 - 212 Jacobi 1997a Jacobi, C.A. et al.: Peritoneal instillation of taurolidin and heparin for preventing intraperitoneal tumor growth and trocar metastases in laparoscopic operations in the rat model. Arch Chir. 382 (1997), S.31 - 36 Jacobi 1997b Jacobi, C.A. et al.: Pneumoperitoneum with carbon dioxide stimulates growth of malignant colonic cells. Surgery. 121 (1997), S.72 - 78 Jacobi 1997c Jacobi, C.A. et al.: Inhibition of peritoneal tumor cell growth and implantation i laparoscopic surgery in a rat model. Am J Surg. 121 (1997), S.72 - 78 Jacobi 1998a Jacobi, C.A. et al.: Increased systemic inflammation after laparotomy vs. laparoscopy in an animal model of peritonitis. Arch Surg. 133 (1998), S.258 - 262 Jacobi 1998b Jacobi, C.A. et al. : The impact of laparoscopy with carbon dioxide versus helium on immunologic function and tumor growth in a rat model Dig Surg . 15 (1998), S.110 - 116 Jacobi 1998c Jacobi, C.A. et al.: The impact of elevated intraabdominal pressure during laparoscopy on tumor growth and trocar metastases in a rat model. Br J Surg. 85 (1998), S.72 - 78 Jacobi 1999a Jacobi, C.A. et al.: New therapeutic strategies to avoid intra- and extraperitoneal metastases during laparoscopy: results of a tumor model in the rat. Dig Surg . 16 (1999), S.393 - 399 Jacobi 2000a Jacobi, C.A. et al.: Cardiopulmonary changes during laparoscopy and vessel injury: comparison of CO2 and helium in an animal model. Langenbecks Arch Surg. 385 (2000), S.459 - 466 Johannsen 1989 Johannsen, G. et al. : The effect of general anesthesia on the hemodynamic events during laparoscopy with CO2 insufflation. Acta Anaesthesiol Scand. 33 (1989), S.132 - 136 Johnson 1997 Johnson, P.L. et al.: Laparoscopy: Gasless vs. CO2 Pneumoperitoneum J Reprod Med. 42 (1997), 5, S.255 - 259 Jonecko 1990 Jonecko, A. : Das menschliche Peritoneum und die menschliche Peritonitis in ultrastrukturellen und immunhistochemischen Untersuchungen Z Mikrok Anat Forsch. 104 (1990), S.907 - 943 Juhl 1994 Juhl, H. et al.: Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer. 57 (1994), S.330 - 335 Junqueira/Carneiro 1996 Junqueira, L.C.; Carneiro, J.: Histologie. . 4. korrigierte und übersetzte Auflage

Berlin

, Springer Verlag, 1996 S.326 - 341 Karaviannakis 1997 Karaviannakis A.J. et al.: Systemic stress response after laparoscopic or open cholecystectomy: a randomized trial. Br J Surg. 84 (1997), S.467 - 471 Kaufman 1982 Kaufman, O.Y. et al. : Responses of peritoneal mesothelial cells in rats with aseptic and bacterial peritonitis Bull Exp Biol Med. 94 (1982), S.100 - 104 Kim 2002 Kim, W.W. et al.: Comparison of immune preservation between CO2 pneumoperitoneum and gasless abdominal lift laparoscopy. JSLS. 6 (2001), 1, S.11 - 15 Kimura 1985 Kimura A. et al. : Peritoneal mesothelial cell injury factors in rat cancerous ascites Cancer Res. 45 (1985), S.4330 - 4333 Kirk 1997 Kirk, R.M.: Chirurgische Techniken. 3. erweiterte

Stuttgart

, Georg Thieme, 1997 Koga 1980 Koga, S. et al.: A scanning electron microscopic study on the peritoneal implantation of ascites hepatoma AH100B cells in rats. Gann. 71 (1980), S.8 - 13 Koivusalo 1998 Koivusalo, A.M. et al.: A comparison of gasless mechanical and conventional carbon dioxide pneumoperitoneum methods for laparoscopic cholecystectomy Anesth Analg. 86 (1998), 1, S.153 - 158 Koks 2000 Koks, C.A.M. et al.: Menstruum induces changes in mesothelial cell morphology Gynecol Obstet invest. 50 (2000), S.13 - 18 Kopernik 1998 Kopernik, G. et al.: The effect of a high partial pressure of carbon dioxide environment on metabolism and immune functions of human peritoneal cells. Relevance to carbon dioxide pneumoperitoneum. Am J Obstet Gynecol. 179 (1998), S.1503 - 1510 Kremer, Platzer, Schreiber, Steichen 2001 Steichen et al: Instruments and Methods Hrsg.: Kremer K, Platzer W, Schreiber HW, Steichen FM : Minimally invasive abdominal Surgery. 1.

Stuttgart, New York

, Thieme, 2001 S.6-58 Kuntz 2000 Kuntz, C. et al.: Effect of pressure and gas type on intraabdominal, subcutaneous and blood pH in laparoscopy. Surg Endosc. 12 (2000), S.367 - 371 Lacy 1995 Lacy A.M. et al.: Short - term outcome analysis of a randomized study comparing laparoscopic versus open colectomy for colon cancer. Surg endosc. 9 (1995), S.1101 - 1105 Larsen 2001 Larsen, J.F. et al: Randomized comparison of conventional and gasless laparoscopic cholecystectomy: operative technique, postoperative course and recovery. Gastrointest Surg. 5 (2001), 3, S.330 - 335 Lauroy 1994 Lauroy, J. et al.: Metastatic recurrence at cannula site: should digestive cancers still be managed by laparoscopy. Br J Surg. 81 (1994), Suppl., S.31 Lechaux 2002 Lechaux, D. et al.: Five - year results of 206 laparoscopic left colectomies for cancer. Surg endosc. 2002, S.DOI: 10.1007/s00464-002-9011-7 Lee 1998 Lee, et al.: Traumatic handling of the tumor independent of pneumoperitoneum increases port site implantation rate of colon cancer in a murine model. Surg Endosc. 12 (1998), S.828 - 834 Lethola 1986 Lethola, A. et al.: The effect of peritoneal exsudate on peritoneal morphology in experimental acute pancreatitis: A histologic and scanning electron microscopic study. Scand J gastroenterol. 21 (1986), S.1173 - 1179 Lierse 1985 Lierse, W.: Das Peritoneum: Anatomische Grundlagen Chirurg. 56 (1985), S.357 - 359 Lord 1998 Lord, R.V.N. et al.: Incidence of deep vein thrombosis after laparoscopic vs. minilaparotomy CCE Arch Surg . 133 (1998), S.967 - 973 Majeed 1996 Majeed, A.W. et al. : Randomised, prospective, single - blind comparison of laparoscopic versus small - incision cholecystectomy Lancet. 347 (1996), S.989 - 994 Mathew 1996 Mathew, G. et al.: Wound metastases following laparoscopic and open surgery for abdominal cancer in a rat model. Br J Surg. 83 (1996), S.1087 - 1090 Mathew 1997 Mathew, G. et al.: The effect of laparoscopy on the movement of tumor cells and metastasis to surgical wounds. Surg Endosc. 11 (1997), S.1163 - 1166 McCourt 2000 McCourt, M. et al.: Taurolidine inhibits tumor cell growth in vitro and in vivo. Ann Surg Oncol. 7 (2000), S.685 - 691 McMahon 1993 McMahon, A.J. et al.: Comparison of metabolic responses to laparoscopic and minilaparotomy cholecystectomy. Br J Surg. 80 (1993), S.1255 - 1258 McMahon 1994 McMahon, A.M. et al.: Helium pneumoperitoneum for laparoscopic cholecystectomy: ventilatory and blood gas changes. Br J Surg. 81 (1994), S.1033 - 1036 Meyer/Hüttl 2001 Meyer, G.; Hüttl, T.P.: Laparoscopic surgery in Europe: Development and education: a German perspective, Surgical Endoscopy . 15 (2001), S.229 - 231 Michailova 1999 Michailova, K. et al.: Scanning and transmission electron microscopic study of visceral and parietal peritoneal regions in the rat. Ann Anat. 181 (1999), S.253 - 260 Milsom 1998 Milsom, J.W. et al.: A prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report. J Am Coll Surg. 187 (1998), S.46 - 54 Milsom 1998i Milsom, J.W. et al.: A prospective, randomised trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report. J AM Coll Surg. 187 (1998), S.46 – 54 Miura 2001 Miura, Y. et al.: Gasless hand - assisted laparoscopic surgery for colorectal cancer: an option for poor cardiopulmonary reserve. Dis Colon Rectum. 44 (2001), 6, S.896 - 898 Murdock 2000 Murdock CM et al. : Tisk factors for hypercarbia, subdutaneous emphysema, pneumothorax, and pneumomediastinum during laparoscopy Obstet Gynecol. . 95 (2000), S.704-709 Neuhaus 2001 Neuhaus, S.J. et al.: Helium and other alternative Insufflation gases for laparoscopy. A review. Surg Endosc. 15 (2001), S.553 - 560 Neuhaus 2001b Neuhaus, S.J. et al.: Metabolic and immunologic consequences of laparoscopy with helium or carbon dioxide insufflation: a randomized clinical study ANZ J Surg. 71 (2001), S.447 - 452 Nezhat 1998 Nezhat, C.R. et al.: Laparoscopic Surgery Hrsg.: Niederhuber, H.E.: Fundamentals of surgery. 1.

Stanford, Connecticut

, Appleton and Lange, 1998 S.116 - 128 Nilsson 2000 Nilsson, G. et al. : Randomized clinical trial of laparoscopic versus open fundoplication: blind evaluation of recovery and discharge period. Br J Surg. 87 (2000), S.873 - 878 Ogihara 1999 Ogihara, Y. et al.: Abdominal wall lift versus carbon dioxide insufflation for laparoscopic resection of ovarian tumors J Clin Anaeth. 11 (1999), 5, S.406 - 412 Ordemann 2001 Ordemann, J. et al.: Cellular and humoral inflammatory response after laparoscopic and conventional colorectal resections - Results of a prospective randomized trial. Surg Endosc. 15 (2001), S.600 - 608 Ortega 1996 Ortega, A.E. et al.: A prospective randomiezed comparison of the metabolic and stress hormonal responses of laparoscopic and open cholecystectomy J AM Coll Surg. 183 (1996), S.249 - 256 Papadimitriou 1973 Papdimitriou, J.M. et al.: Surface characteristics of macrophages, epithelioid and giant cells using scanning electron microscopy. Exp cell Res. 76 (1973), S.353 - 362 Perttila 1999 Perttila, J. et al.: Immune response after laparoscopic and conventional nissen fundoplication. Eur J Surg. 21 (1999), S.165 - 170 Poulin 1999 Poulin, E.C. et al.: Laparoscopic resection does not adversely affect early survival curves in Patient undergoing surgery for colorectal adenocarcinoma. Ann Surg. 229 (1999), S.487 - 492 Puttick 1999a Puttick, M.I.: Full laparotomy in a warm humid environment causes less postoperative tumour growth than full laparotomy in room air. Data presented of the Third International Laparoscopic Physiology Conference..

New York

, March 1999 Puttick 1999b Puttick, M.I. et al.: Carbon dioxide pneumoperitoneum increases tumour cell invasiveness. Data presented of the Third International Laparoscopic Physiology Conference.

New York

, March 1999 Raz 1976 Raz, A. and Goldman, R.: Effect of hashish compounds on mouse peritoneal macrophages Lab Invest. 68 (1976), S.69 - 76 Reilly 1996 Reilly, W.T. et al.: Wound recurrence following conventional treatment of colorectal cancer: A rare but perhaps underestimated problem. Dis colon rectum. 39 (1996), S.200 - 207 Rittmann/Koller 1994 Rittmann, W.W.; Koller, C.: Laparoskopische Chirurgie - Manual für das Operationsteam. 1.

Bern

, Verlag Hans Huber, 1994 Roberts 1997 Roberts, M.W. et al.: Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases. Surg Endosc. 11 (1997), S.341 - 346 Sarli 2000 Sarli l et al.: Prospective randomized trial of low-pressure pneumoperitoneum for reduction of shoulder-tip pain following laparoscopy. Br J Surg. 87(2000), S.161-1165 Schaeff 1998a Schaeff, B. et al.: elektronenmikroskopische Veränderungen am Peritoneum nach laparoskopischen Operationen Langenbecks Arch Chir Suppl 1. 1998, S.571 - 573 Schaeff 1998b Schaeff, B. et al.: Port Site recurrence after laparoscopic surgery: A review. Dig Surg. 12 (1998), S.485 - 495 Schiedeck 2000 Schiedeck, T.H. et al.: Laparoscopic surgery for the cure of colorectal cancer: results of a German five - center study. Dis Colon Rectum. 43 (2000), S.1 - 8 Schneider 1999 Schneider, C. et al.: Surgical technique is a major factor in the incidence of port - site recurrences. Data Presented of the third international laparoscopic physiology conference.

New York

, March 1999 Schulte-Steinberg 1996 Schulte - Steinberg, H. et al.: Sind Risikopatienten zur minimal - invasiven Operation mit CO2 - Pneumoperitoneum geeignet? Chirurg. 67 (1996), S.72 - 76 Schulze 1999 Schulze, S. et al.: Cardiovascular and respiratory changes and convalescence in laparoscopic colonic surgery. Arch Surg. 134 (1999), 10, S.1112 - 1118 Schwenk 1998 Schwenk, W. et al.: laparoscopic versus conventional colorectal resection: a prospective randomized study of postoperative ileus and early postoperative feeding. Langenbecks Arch Surg. 383 (1998), S.49 - 55 Schwenk 1999 Schwenk, W. et al.: Pulmonary function following laparoscopic or conventional colorectal resection: a randomized controlled evaluation. Arch Surg. 134 (1999), S.6 - 12 Sendt 1999 Sendt, W. et al.: Local inflammatory peritoneal response to operative trauma: studies on cell activity, cytokine expression, and adhesion molecules. Eur J Surg. 165 (1999), 11, S.1024 - 1030 Skipper 1989 Skipper, D. et al.: Enhanced growth of tumour cells in healing colonic anastomoses and laparotomy wounds. Int J Colorect Dis. 1989, S.172 - 177 Squirrel 1998 Squirrel, D.M. et al. : A randomized, prospective, blinded comparison of postoperative pain, metabolic response, and perceived health after laparoscopic and small incision cholecystectomy Surgery. 123 (1998), S.528 - 533 Stage 1997 Stage, J.H. et al.: Prospective randomized study of laparoscopic versus open colonic resectible adenocarcinoma. Br J Surg. 84 (1997), S.391 - 396 Stuttmann 1995 Stuttmann, R. et al.: Hemodynamic changes during laparoscopic cholecystectomy in the high - risk patient. Endosc surg. 3 (1995), S.174 - 179 Suematsu 2001 Suematsu, T. et al.: Morphology of the murine peritoneum after pneumoperitoneum vs. laparotomy: A scanning electron microscopy study. Surg Endosc. 15 (2001), Tate 1993 Tate, J.J.T. et al.: Laparoscopic versus open appendectomy: a prospective randomised trial. Lancet. 342 (1993), S.633 - 637 Verger 1983 Verger, C. et al. : Acute changes in peritoneal morphology and transport properties with infectious peritonitis and mechanical injury Kidney International. 23 (1983), S.823 - 831 Virtanen 1984 Virtanen, J. et al. : The effect of fixation on corneal endothelial cell dimensions and morphology in scanning electron microscopy. Acta Ophthal. 62 (1984), S.577 – 585 Volpino 1998 Volpino, P. et al.: Hemodynamic and pulmonary changes during and after laparoscopic cholecystectomy. A comparison with traditional surgery. Surg endosc. 12 (1998), S.119 - 123 Volz 1999a Volz, J. et al.: Characteristic alterations of the peritoneum after carbon dioxide pneumoperitoneum. Surg Endosc. 13 (1999), S.611 - 619 Volz 1999b Volz, J. et al.: The influence of pneumoperitoneum used in laparoscopic surgery on an intraabdominal tumor growth. Cancer. 86 (1999), S.770 - 774 Wallace 1997 Wallace, D. H. et al.: Randomized trial of different insufflation pressures for laparoscopic cholecystectomy Brit J Surg. 84 (1997), S.455 - 458 Watters/Buck 1972 Watters, W.B.; Buck, R.C.: Scanning electron microscopy of mesothelial regeneration in the rat Lab Invest. 26 (1972), S.604 - 609 Wexner 1995 Wexner, S.D. et al.: Port site metastases after laparoscopic colorectal surgery for cure of malignancy. Br J Surg. 82 (1995), 3, S.295 - 298 Whelan 1996 Whelan, R.L. et al.: Trocar sit recurrence is unlikely to result from aerosolization of tumor cells. Dis Colon Rectum. 39 (1996), S.7 - 13 Whelan 2001 Whelan, R.L.: Laparotomy, Laparoscopy, cancer and beyond Surgical endosc. 15 (2001), S.110 - 115 Whitaker/Papadimitriou 1985 Whitaker, D.; Papadimitriou, J.: Mesothelial healing: Morphological and kinetic investigations. J Pathology. 145 (1985), S.159 - 175 Wildbrett 2002 Wildbrett, P. et al.: Impact of laparoscopic gases on peritoneal microenvironment and essential parameters of cell function. Surg Endosc. 16 (2002), Wurst 1996 Wurst, H. et al.: Zur Frage des CO2 - Speicherung bei laparoskopischer Cholecystektonie mit CO2 - Pneumoperitoneum der Anaesthesist. 44 (1996), S.147 - 153