Einfluss von Cyclodextrinen auf die okulare Verfügbarkeit von Antiglaukomatosa und Immunsuppressiva in vitro / in vivoSigrid Knapp-UlrichI.123II.4III.5III.1.III.1.1.518#35167III.1.2.8509#1519III.1.3.1011III.1.4.12III.2.III.2.1.131415III.2.2.16171819III.2.3.202122III.3.23III.3.1.III.3.1.1.24III.3.1.2.III.3.2.25III.3.2.1.2627III.3.2.2.2829303132III.3.3.33III.3.3.1.34III.3.3.2.35III.3.4.36III.3.5.37III.4.III.4.1.III.4.1.1.3839III.4.1.2.4041424344III.4.1.3.45III.4.1.4.46III.4.1.5.III.4.1.5.1.47III.4.1.5.2.48III.4.1.5.3.III.4.1.5.4.49III.4.1.5.5.50IV.IV.1.51IV.2.52184#45364#234288#50IV.3.53IV.3.1.IV.3.1.1.IV.3.1.2.54128#39IV.3.1.3.293#22855117#41IV.3.2.56IV.4.IV.5.5758V.V.1.V.1.1.596061V.1.2.62V.1.2.1.63V.1.2.2.646566566#310V.1.2.3.676869529#26170537#265530#289V.1.2.4.7172V.1.2.5.73747576777879V.1.2.6.80V.1.2.6.1.8182567#28683V.1.2.6.2.8485517#370V.1.3.868788599#806V.1.4.8990V.2.9192V.2.1.93481#27394605#32295470#286474#27096502#287V.2.2.97V.2.3.9899V.2.4.100101102V.2.5.103V.3.104V.3.1.V.3.1.1.105106V.3.1.2.107559#274V.3.2.108V.3.2.1.109110V.3.2.2.111532#256112V.3.2.3.113V.3.2.4.114502#352115V.3.3.VI.116VI.1.117118119VI.2.VI.2.1.VI.2.1.1.VI.2.1.2.120VI.2.1.3.VI.2.1.4.VI.2.1.5.VI.2.1.6.VI.2.1.7.121117#43VI.2.1.8.VI.2.2.122123VI.2.2.1.VI.2.2.2.124VI.2.2.3.125VI.2.2.4.126VI.2.2.5.78#46127VI.2.3.VI.2.3.1.VI.2.3.2.VI.2.3.2.1.128VI.2.3.2.2.VI.2.3.2.3.129VI.2.4.130VI.2.4.1.VI.2.4.2.131409#226132290#187VI.2.4.3.133VI.2.4.4.VI.2.4.4.1.134135VI.2.4.4.2.VI.2.5.VI.2.6.136VI.2.6.1.137VI.2.6.2.138VI.2.6.3.VI.2.6.3.1.VI.2.6.3.2.VI.2.6.3.3.139VI.2.6.3.4.VI.2.7.VI.2.7.1.VI.2.7.2.140VI.2.7.3.VI.2.7.3.1.141VI.2.7.3.2.VI.2.7.3.3.VI.2.7.3.4.142VI.2.7.3.5.143VI.2.7.3.6.VI.2.8.144145VI.2.9.VI.2.9.1.146VI.2.9.2.VII.147148149150151 Literaturverzeichnis155156157158159160161162163164165166167168169170 Publikationen171172173ErklärungdeInhaltsverzeichnisHilfe Literaturverzeichnis 1 Abdel Rahman, A.A., Khidr, S.H., Ahmed, S.M., Aboutaleb, A.E., Evaluation of chloramphenicol- β -cyclodextrin inclusion complex, Eur. J. Pharm. Biopharm. 37, 34-37 (1991) 2 Ahmed, I., Gokhale, R.D., Shah, M.V., Patton, T.F., Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea, J. Pharm. Sci. 76, 583-586 (1987) 3 Ahmed, I., Patton, T., Effect of pH and buffer on precorneal disposition and ocular penetration of pilocarpine in rabbits, Int. J. Pharm. 19, 215-227 (1984) 4 Ahmed, I., Patton, T.F., Importance of the noncorneal absorption route in topical ophthalmic drug delivery, Invest. Ophthalmol. Vis. Sci. 26, 584-587 (1985) 5 Akiyama, S., Yokoyama, T., Takano, T., Kobayashi, C., Kanai, A., Application of cyclosporin for corneal graft, Nippon Ganka Gakkai Zasshi 97, 378-382 (1993) 6 Allison, A.C., Almquist, S.J., Muller, C.D., In vitro immunosuppressive effects of mycophenolic acid and an ester prodrug, Transplant. Proc. 23 , Suppl. 2, 10-14 (1991) 7 Anaizi, N.H., Swenson, C.F., Dentinger, P.J., Stability of mycophenolate mofetil in an extemporaneously compounded oral liquid, Am. J. Health-Syst. Pharm. 55, 926-929 (1998) 8 Ashton, P., Podder, S.K., Lee, V.H.L., Formulation influence on conjunctival penetration of four beta-blockers in the pigmented rabbit: a comparison with corneal penetration, Pharm. Res. 8, 1166-1174 (1991) 9 Ausschuss für Arzneispezialitäten , Europäischer Öffentlicher Beurteilungsbericht: Cellcept^® , CPMP 767, Rev. 5 (2003) 10 Auterhoff, H., Knabe, J., Höltje, H.D., Lehrbuch der Pharmazeutischen Chemie, Wiss. Verlagsgesellschaft mbH, S. 512-524 (1994) 11 Babiole, M., Wilhelm, F., Schoch, C., In vitro corneal permeation of unoprostone isopropyl (UI) and its metabolism in the isolated pig eye, J. Ocular Pharmacol. Ther. 17, 159-172 (2001) 12 Bary, A.R., Tucker, I.G., Davies, N.M., Considerations in the use of hydroxypropyl-beta-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone, Eur. J. Pharm. Biopharm. 50, 237-244 (2000) 13 Bauer, K.H., Frömming, K.-H., Führer, C. (Hrsg.), Lehrbuch der Pharmazeutischen Technologie, Georg Thieme Verlag,

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