[Seite 155↓]


1 Bachert, C., Allergic rhinitis. Pathophysiology, diagnosis, differential diagnosis and therapy, Z. Ärztl. Fortbil. Qualitätssich. 91, 501-505 (1997)

2 Wichtige Mitteilungen der Arzneimittelkommission Deutscher Apotheker, DAZ 138, 4016 (1998)

3 Wichtige Mitteilungen der Arzneimittelkommission Deutscher Apotheker, DAZ 142, 3630 (2002)

4 Wichtige Mitteilungen der Arzneimittelkommission Deutscher Apotheker, DAZ 142, 5228 (2002)

5 Chien, Y.W., Su, K.S.E., Chang, S.-F., Nasal systemic drug delivery, Marcel Dekker Inc. New York, Basel, 1989, S. 200-219

6 Fisher, A.N., Absorption across the nasal mucosa of animal species: Compounds applied and mechanisms involved, Prog. Drug Metabol. 12, (1990) 87-145

7 Ugwoke, M.I., Verbeke, N., Kinget, R., The biopharmaceutical aspects of nasal mucoadhesive drug delivery, J. Pharm. Pharmacol. 53, 3-22 (2001)

8 Hussain, A., Hirai, S., Bawarshi, R., Nasal absorption of propranolol from different dosage forms by rats and dogs, J. Pharm. Sci. 69, 1411-1413 (1980)

9 Provasi, D., Ascentiis, A.D., Colombo, P., Catellani, P.L., Nasal powders of progesterone: Manufacturing and bioavailability, Eur. J. Pharm. Bull. 40, 223-227 (1994)

10 van Cauwenberge, P., Bachert, P., Passalacqua, G., Bousquet, J., Canonica, G.W., Durham, S.R., Fokkens, W.J., Howarth, P.H.L., Howarth, V., Malling, H.J., Mygind, N., Passali, D., Scaddingm, G.K., Wang, D.Y., Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology, Allergy 55, 116-134 (2000)

11 Meltzer, A.N., An overview of current pharmacotherapy in perennial rhinitis, J. Allergy Clin. Immunol. 95, 1097-1100 (1995)

12 Aikawa, K., Matsumoto, K., Uda, H., Tanaka, S., Shimamura, H., Aramaki, Y., Tsuchiya, S., Prolonged release of drugs from O/W emulsion and residence in rat nasal cavity, Pharm. Drug Dev. Technol. 3, 461-469 (1998)

13 Schmidt, M.C., Peter, H., Lang, S.R., Ditzinger, G., Merkle, H.P., In vitro cell model to study nasal mucosal permeability and metabolism, Adv. Drug Deliv. Rev. 29, 51-79 (1998)

14 Thews, G., Mutschler, E., Vaupel, P., Anatomie, Physiologie und Pathophysiologie des Menschen, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1999, S. 292-296, 710 ff.

15 Sommer, K., Der Mensch, Weltbild Verlag GmbH Augsburg, 1994, S. 255 ff.

16 Merkus, F.W., Verhoef, J.C., Schipper, N.G., Marttin, E., Nasal mucociliary clearance as a factor in nasal drug delivery, Adv. Drug Deliv. Rev. 29, 13-38 (1998)

17 Jones, N.S., CT of the paranasal sinuses: A review of the correlation with clinical, surgical and histopathological findings, Clin. Otolaryngol. 27, 11-17 (2002)

18 Mutschler, E., Arzneimittelwirkungen, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2001, S. 88 ff., 617 ff.

19 Forth, W., Hentschler, D., Rummel, W., Allgemeine und spezielle Pharmakologie und Toxikologie, Spektrum Akademischer Verlag Heidelberg, Berlin, Oxford, 1996, S. 319-325

20 Bousquet, J., Chanal, I., Alquie, M.C., Prevention of pollen rhinitis symptoms: Comparison of fluticasone propionate aqueous nasal spray and disodium cromoglycate aqueous nasal spray. A multicenter, double-blind, double-dummy, parallel-group study, Allergy 48, 327-333 (1993)

21 Duchêne, D., Ponchel, G., Nasal administration: A tool for tomorrow’s systemic drug administration, Drug Dev. Ind. Pharm. 19, 101-122 (1993)

22 Cornaz, A., Buri, P., Nasal mucosa as an absorption barrier, Eur. J. Pharm. Biopharm. 40, 261-270 (1994)

23 Corbo, D., Liu, J.-C., Chien, Y.W., Characterisation of the barrier properties of mucosal membranes, J. Pharm. Sci. 79, 202-206 (1990)

24 McMartin, C., Hutchinson, L.E.F., Hyde, R., Peters, G.E., Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity, J. Pharm. Sci. 76, 535-540 (1987)

25 Khanvilkar, K., Donovan, M.D., Flanagan, D.R., Drug transfer through mucus, Adv. Drug Deliv. Rev. 48, 173-193 (2001)

[Seite 156↓]

26 Marttin, E., Romeijn, S.G., Verhorf, J.C., Merkus, F.W.H.M., Nasal absorption of dihydorergotamine from liquid and powder formulations in rabbits, J. Pharm. Sci. 86, 802-807 (1997)

27 Lim, S.T., Forbes, B., Berry, D.J., Martin, G.P., Brown, M.B., In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits, Int. J. Pharm. 231, 73-82 (2002)

28 Critchley, H., Davis, S.S., Farraj, N.F., Illum, L., Nasal absorption of desmopressin in rats and sheep, J. Pharm. Pharmacol. 46, 651-656 (1993)

29 Morimoto, K., Morisaka, K., Kamada, A., Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel, J. Pharm. Pharmacol. 37, 134-136 (1984)

30 Merkus, F.W.H.M., Schipper, N.G.M., Hermens, W.A.J.J., Romeijn, S.G., Verhoef, J.C., Absorption enhancers in nasal drug delivery: Efficacy and safety, J. Control. Release 24, 201-208 (1993)

31 Sakar, M.A., Drug metabolism in the nasal mucosa, Pharm. Res. 9, 1-8 (1992)

32 Edman, P., Björk, E., Ryden, L., Microspheres as a nasal delivery system for peptide drugs, J. Control. Release 21, 165-172 (1992)

33 Ishida, M., Machida, Y., Nambu, N., Nagai, T., New mucosal dosage form of insulin, Chem. Pharm. Bull. 29, 810-816 (1981)

34 Cass, L.M.R., Efthymiopoulus, C., Bye, A., Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers, Clin. Pharmacokinet. 36, 1-11 (1999)

35 Almeida, A.J., Alpar, H.O., Nasal delivery of vaccines, J. Drug Target. 3, 455-467 (1996)

36 Verhoef, J.C., Merkus, F.W.H.M., Nasal absorption enhancement: Relevance to nasal drug delivery, Hrsg.: de Boer, A.G., Drug absorption enhancement, Harwood academic publishers Chur, 1994, S. 120 ff.

37 Dondeti, P., Hossein, Z., Nedham, T.E., Bioadhesive and formulation parameters affecting nasal absorption, Int. J. Pharm. 127, 115-133 (1996)

38 Gizurarson, S., Animal models for intranasal drug delivery studies, Acta Pharm. Nord. 2, 105-122 (1990)

39 Illum, L., Nasal delivery. The use of animal models to predict performance in man, J. Drug. Target. 3, 427-442 (1995)

40 Dondeti, P., Zia, H., Needham, T.E., Luzzi, L.A., Development of a new non-surgical perfusion technique for evaluation of nasal drug delivery, Pharmazie 49, 505-509 (1994)

41 Wadell, C., Björk, E., Camber, O., Nasal drug delivery – Evaluation of an in vitro model using porcine nasal mucosa, Eur. J. Pharm. Sci. 7, 197-206 (1999)

42 Schmidt, M.C., Simmen, D., Hilbe, M., Boderke, P., Ditzinger, G., Sandow, J., Lang, S., Rubas, W., Merkle, H.P., Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium, J. Pharm. Sci. 89, 396-406 (2000)

43 Borchardt, R.T., Smith, P.L., Wilson, G., Models for assessing drug absorption metabolism, Pharm. Biotechnol. 8, 309-323 (1996)

44 Kissel, T., Werner, U., Nasal delivery of peptides: An in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium, J. Control. Release 53, 195-203 (1998)

45 Werner, U., Kissel, T., In-vitro cell culture models of nasal epithelium. A comparative histochemical investigation of their suitability for drug transport studies, Pharm. Res. 13, 978-988 (1996)

46 Batts, A.H., Mariott, C., Martin, G.P., Bond, S.W., Greaves, J.L., Wilson, C.G., The use of a radiolabelled saccharin solution to monitor the effect of the preservatives thiomersal, benzalkonium chloride and EDTA on human nasal clearance, J. Pharm. Pharmacol. 43, 180-185 (1991)

47 Petruson, B., Structural and functional aspects of cells in the nasal mucociliary system, Arch. Otolaryngol. 110, 576-581 (1984)

48 Mygind, N., Änggård, A., Anatomy and physiology of the nose – Pathophysiologic alterations in allergic rhinitis, Clin. Rev. Allergy 2, 173-188 (1984)

49 Sezaki, H., Mucosal penetration enhancement, J. Drug Target. 3, 175-177 (1995)

50 Noach, A.B.J., Hurni, M.A., de Boer, A.B., Breimer, D.D., Drug transport and its enhancement via the paracellular pathway, Hrsg.: de Boer, A.G., Drug absorption enhancement, Harwood academic publishers Chur, 1994, S.291 ff.,

51 Hochman, J., Atursson, P., Mechanism of absorption enhancement and tight junction regulation, J. Control. Release 29, 253-267 (1994)

[Seite 157↓]

52 Borchardt, G., Lueßen, H.L., de Boer, A.G., Verhoef, J.C., Lehr, C.-M., Junginger, H.E., The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro, J. Control. Release. 39, 131-138 (1996)

53 Wikman-Larhed, A., Artursson, P., Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption, J. Pharm. Sci. 3, 471-183 (1995)

54 Frederiksen, O., Röpke, M., Hansen, M., Carstens, S., Hilm, M., Christensen, P., Colding-Jorgensen, A., Danielsen, G., Phospholipid-induced changes of the rabbit nasal mucosa in vitro, Am. J. Physiol. 271, 646-655 (1996)

55 Marttin, E., Verhoef, J.C., Spies, F., van der Meulen, J., Nagelkerke, J.F., Koerten, H.K., Merkus, F.W.H.M., The effect of methylated β-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium: Electron microscopic and confocal laser scanning microscopic visualization studies, J. Control. Release 57, 205-213 (1999)

56 Pujara, C.P., Shao, Z., Duncan, M.R., Mitr, A.K., Effect of formulation variables on nasal epithelial cell integrity: Biochemical evaluations, Int. J. Pharm. 114, 197-203 (1995)

57 Dodane, V., Khan, M.A., Mervin, J.R., Effect of chitosan on epithelial permeability and structure, Int. J. Pharm. 181, 21-32 (1999)

58 Carstens, S., Danielsen, G., Guldhammer, B., Frederiksen, O., Transport of insulin across rabbit nasal mucosa in vitro induced by didecanoyl-L-α-phosphatidylcholine, Diabetes 42, 1032-1040 (1993)

59 Bechgaard, E., Gizurarson, S., Jorgensen, L., Larsen, R., The viability of isolated rabbit nasal mucosa in the ussing chamber, and the permeability of insulin across the membrane, Int. J. Pharm. 87, 125-132 (1992)

60 Hsiung, C.C., Skalak, R., Hydrodynamic and mechanical aspects of endothelial permeability, Biorheology 21, 207-221 (1984)

61 Hosoya, K., Kubo, H., Natsume, H., Sugibayashi, K., Morimoto, Y., Evaluation of enhancers to increase nasal absorption using ussing chamber technique, Biol. Pharm. Bull. 21, 207-221 (1994)

62 Gizurarson, S., Tamura, S., Kurata, T., Estimating tissue permeability and other bioelectrical parameters using membrane voltage and short-circuit current, Chem. Pharm. Bull. 39, 1636-1627 (1991)

63 Kubo, H., Hosoya, K., Natsume, H., Sugibayashi, K., Morimoto, Y., In vitro permeation of several model drugs across rabbit nasal mucosa, Int. J. Pharm. 103, 27-36 (1994)

64 Cotton, C.U., Stutts, M.J., Knowles, M.R., Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis, J. Clin. Invest. 79, 80-85 (1987)

65 Bechgaard, E., Jorgenson, L., Larsen, R., Gizurarson, S., Cartensen, J., Hvass, A., Insulin and didecanoyl-L-α-phosphatidylcholine: In vitro study of the transport through rabbit nasal mucosa, Int. J. Pharm. 89, 147-153 (1993)

66 Hosoya, K., Kubo, H., Natsume, H., Sugibayashi, K., Morimoto, Y., Yamashita, S., The structural barrier of absorptive mucosae: Site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits, Biopharm. Drug Pos. 14, 685-696 (1993)

67 Schmidt, M.C., Rubas, W., Merkle, H.P., Nasal epithelial permeation of thymotrinan (TP3) versus thymocartin (TP4): Competitive metabolism and self-enhancement, Pharm. Res. 17 , 200-2008 (2002)

68 Quarishi, M.S., Jones, N.S., Mason, J., The rheology of nasal mucus: A review, Clin. Otolaryngol. 23, 403-413 (1998)

69 Middleton, P.G., Pollard, K.A., Wheatley, J.R., Hypertonic saline alters ion transport across the human airway epithelium, Eur. Respir. J. 17, 195-199 (2001)

70 Junginger, H.E., Lehr, C.-M., Bioadhäsive Arzneistoffabgabesysteme und Arzneiformen für perorale und rektale Anwendung, DAZ 130, 791-797 (1990)

71 Duch ê ne, D., Touchard, F., Peppas, N.A., Pharmaceutical and medical aspects of bioadhesive systems for drug administration, Drug Develop. Ind. Pharm. 14, 283-318 (1988)

72 Lehr, C.-M., Bioadhäsion und bioadhäsive Arzneiformen, Hrsg.: Müller, R.H., Moderne Arzneiformen, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1998

73 Madsen, F., Eberth, K., Smart, J.D., A rheological examination of the mucoadhesive/mucus interaction: The effect of mucoadhesive type and concentration, J. Control. Release 50, 167-178 (1998)

74 Woodley, J., Bioadhesion: New possibilities for drug administration?, Clin. Pharmacokinet. 40, 77-84 (2001)

[Seite 158↓]

75 Madsen, F., In-vitro evaluation of mucoadhesion, Ph.D.-thesis, The Royal Danish School of Pharmacy, Copenhagen, 1995

76 Mortazavi, S.A., Smart, J.D., An in vitro method for assessing the duration of mucoadhesion, J. Control. Release 31, 207-212 (1994)

77 Peppas, N.A., Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J. Control. Release 2, 257-275 (1985)

78 Herzfeldt, C.-D., Kreuter, J., Grundlagen der Arzneiformenlehre, Springer-Verlag Berlin, Heidelberg, 1999, S. 26 ff., 136, 159, 275 ff. 387 ff.

79 Lehr, C.-M., Bodde, H.E., Bouwstra, A., Junginger, H.E., A Surface energy analysis of mucoadhesion. II: Prediction of mucoadhesive performance by spreading coefficients, Eur. J. Pharm. Sci. 1, 19-30 (1993)

80 Samrt, J.D., Kellaway, I.W., Worthington, H.E.C., An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery, J. Pharm. Pharmacol. 36, 295-299 (1984)

81 Jabbari, E., Wisniewski, N., Peppas, N.A., Evidence of mucoadhesion by chain interpenetration at a poly(acrylic acid)/mucin interface using ATR-FTIR spectroscopy, J. Control. Release 26, 99-108 (1993)

82 Caramella, C., Bonferoni, M.C., Rossi, S., Ferrari, F., Rheological and tensile tests for the assessment of polymer-mucin interactions, Eur. J. Pharm. Biopharm. 40, 213-217 (1994)

83 Ahuja, A., Khar, R.K., Ali, J., Mucoadhesive drug delivery systems, Drug Dev. Ind. Pharm. 23, 489-515 (1997)

84 Lehr, C.-M., Schnurrer, J., Mucoadhesive properties of the mussel adhesive protein, Int. J. Pharm. 141, 251-256 (1996)

85 Bernkop-Schnürch, A., Freudl, J., Comparative in vitro study of different chitosan-complexing agent conjugates, Pharmazie 54, 369-371 (1999)

86 Blanc-Fuente, H., Vila-Dorrio, B., Anguiano-igea, S., Otero-Espinar, K., Blanco-medez, J., Tanned leather: A good model for determining hydrogels bioadhesion, Int. J. Pharm. 138, 103-112 (1996)

87 Rossi, S., Bonferoni, M.C., Ferrari, F., Bertoni, M., Caramella, C., Charakterization of mucin interaction with three viscosity grades of sodium carboxymethylcellulose. Comparison between rheological and tensile testing, Eur. J. Pharm. Sci. 4, 189-196 (1996)

88 Hassan, E.E., Gallo, J.M., A simple rheological method for the in vitro assessment on mucin-polymer bioadhesive bond strength, Pharm. Res. 7, 491-495 (1990)

89 Oechsner, M., Bipolymere Zubereitungen auf Polyacrylsäure-Basis zur Anwendung in der Therapie der Keratoconjunctivitis sicca und des Glaukoms, Dissertation, Humboldt-Universität zu Berlin , Berlin , 1998

90 Rossi, S., Bonferoni, M.C., Caramella, C., Ironi, L., Tentoni, S., Model-based interpenetration of creep profiles for the assessment of polymer-mucin interaction, Pharm. Res. 16, 1456-1463 (1999)

91 Nakamura, F., Ohta, R., Machida, Y., Nagai, T., In vitro and in vivo nasal mucoadhesion of some water-soluble polymers, Int. J. Pharm. 134, 173-181 (1996)

92 Macchione, M., King, M., Lorenzi-Filho, G., Guimaraes, E.T., Zin, W.A., Böhm, G.M., Saldiva, P.H.N., Rheological determinants of mucociliary transport in the nose of the rat, Resp. Physiol. 99, 165-172

93 Rhee, C., Majima, Y., Cho, J., Arima, S., Min, Y., Sakakura, Y., Arch, H., Effects of mucokinetic drugs on rheological properties of reconstituted human nasal mucus, Otolaryngol. Head Neck Surg. 125, 101-105 (1999)

94 Aspden, T.J., Mason, J.D.T., Jones, M.S., Lowe, J., Skaugrud, Ø., Illum, L., Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers, J. Pharm. Sci. 86, 509-513 (1997)

95 Hagers Handbuch der Pharmazeutischen Praxis, Band 9, Stoffe A-D, Springer-Verlag Berlin, Heidelberg, 1993, S. 1108-1110

96 Hartke, K., Hartke, H., Mutschler, E., Rücker, G., Wichtl, M. (Hrsg.), DAB-10 Kommentar für Studierende, Band 3, Monographien A-Z, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1991, N 18

97 Shapiro, G., König, P., Cromolyn sodium: A review, Pharmacotherapy 5, 165-170 (1985)

98 Hueston, C.K., Mast cell stabilizers, Otolaryngol. Head Neck Surg. 107, 841-844 (1992)

[Seite 159↓]

99 Ochoa de Aspuru, E., Lourdes Zaton, A.M., Effect of the antiallergic drug sodium cromoglycate and various derivatives on alkaline phosphatase, J. Enzyme Inhib. 8, 87-95 (1994)

100 Ochoa de Aspuru, E., Lourdes Zaton, A.M., Effect of the antiallergic drug disodium cromoglycate on phosphodiesterase activity, J. Enyzme Inhib. 10, 135-139 (1996)

101 Wang, L., Correia, I., Basu, S., Theoharides, T.C., Ca2+ and phorbol ester effect on the mast cell phosphoprotein induced by cromolyn, Eur. J. Pharm. 371, 241-249 (1999)

102 Ratner, P.H., Ehrlich, P.M., Finemann, S.M., Meltzer, E.O., Skoner, D.P., Use of intranasal cromolyn sodium for allergic rhinitis, Mayo Clin. Proc. 77, 350-354 (2002)

103 Moss, G.F., Jones, K.M., Ritchie, J.T., Cox, J.S.G., Distribution and metabolism of disodium cromoglycate in rats, Tox. Appl. Pharmacol. 17, 691-698 (1970)

104 Hagers Handbuch der Pharmazeutischen Praxis, Band 9, Stoffe E-O, Springer-Verlag Berlin, Heidelberg, 1993, S. 1277-1279

105 Hartke, K., Hartke, H., Mutschler, E., Rücker, G., Wichtl, M. ( Hrsg.), DAB-10 Kommentar für Studierende, Band 3, Monographien M-Z, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1991, O 17

106 Hagers Handbuch der Pharmazeutischen Praxis, Band 9, Stoffe P-Z, Springer-Verlag Berlin, Heidelberg, 1993, S. 1217-1220

107 Deitmer, T., Scheffler, R., The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro, Rhinology 31, 151-153 (1993)

108 Ingels, K.J.A.O., Meeuwsen, F., Graamans, K., Huizing, E.H., Influence of sympathetic and parasympathetic substances in clinical concentrations on human nasal ciliary beat, Rhinology 30, 149-160 (1992)

109 Graf, P., Enerdal, J., Hallen, H., Ten days use of oxymetazoline nasal spray with or without benzalkonium chloride in patients with vasomotor rhinitis, Arch. Otolaryngol. Head Neck Surg. 125, 1128-1132 (1999)

110 Graf, P., Adverse effects of benzalkonium chloride on the nasal mucosa: Allergic rhinitis and rhinitis medicamentosa, Clin. Ther. 21, 1749-1755 (1999)

111 Hagers Handbuch der Pharmazeutischen Praxis, Band 9, Stoffe, Springer-Verlag Berlin, Heidelberg, 1993, S. 414-416

112 Bernstein, I.L., Is the use of benzalkonium chloride as a preservative for nasal formulations a safety concern? A cautionary note based on compromised mucociliary transport, J. Allergy Clin. Immunol. 105, 39-44 (2000)

113 Hagers Handbuch der Pharmazeutischen Praxis, Band 9, Stoffe E-O, Springer-Verlag Berlin, Heidelberg, 1993, S. 5 ff.

114 Rimpler, H. (Hrsg.), Biogene Arzneistoffe, Deutscher Apotheker Verlag Stuttgart, 1999, S. 129 ff.

115 Crater, D.L., van de Rijn, I., Hyaluronic acid synthesis operon (has) expressions in group A streptococci, J. Biol. Chem. 31, 18452-18458 (1995)

116 Sintzel, M.B., Bernatchez, S.F., Tabatabay, C., Gurny, R., Biomaterials in ophthalmic drug delivery, Eur. J. Pharm. Biopharm. 42, 358-374 (1996)

117 Ryden, L., Edman, P., Effect of polymers and microspheres on the nasal absorption of insulin in rats, Int. J. Pharm. 83, 1-10 (1992)

118 Döppenschmidt, S., Entwicklung und Validierung analytischer Methoden zur Bestimmung verschiedener Glucocorticoide in Humanplasma und Humanserum , Dissertation, Humboldt-Universität zu Berlin , Berlin , 1996

119 Kromidas, S. ( Hrsg), Handbuch der Validierung in der Analytik, Wiley-VCH Verlag GmbH Weinheim, 2000

120 International Conference on Harmonisation (ICH) of technical requirements or registration of pharmaceuticals for human use: Guideline on validation of analytical procedures: Methodology, by the IHC Stering committee, IFPMA, Switzerland, (1996)

121 Hartmann, C., Smeyers-Verbeke, J., Massart, D.L., McDowall, R.D., Validation of bioanalytical chromatographic methods, J. Pharm. Biomed. Anal. 17, 193-218 (1998)

122 Gottwald, W. (Hrsg.), RP-HPLC für Anwender, Wiley-VCH Verlag GmbH, Weinheim, 1993

123 Lingemann, H., Munster, H.A., Beynen, J.H., Underberg, W.J., Hulshoff, A., High-performance liquid chromatographic analysis of basic compounds on non-modified silica gel and aluminium oxide with aqueous solvent mixtures, J. Chromatogr. 21, 261-274 (1986)

[Seite 160↓]

124 Hoffmann, T.J., Thompson, R.D., Seifert, J.R., Determination of the nasal decongestant, oxymetazoline hydrochloride, in pharmaceutical formulations by HPLC, Drug Dev. Ind. Pharm. 15, 743-757 (1989)

125 Prüfanweisung zur Gehaltsbestimmung von Xylometazolin-HCl , ct-Arzneimittel , 1997

126 Reviewer guideline: Validation of chromatographic methods , Centre for Drug Evaluation and Research (CDER), Food and Drug Administration, 1994

127 Lee, Y.C., Chan, C.C., System suitability tests for quantitative chromatography methods, Laboratory-Gazette Edition Band 4, 1999, S. 7 ff.

128 NG, L.L, Reversed-phase liquid chromatographic determination of cromolyn sodium in drug substance and select dosage forms, J. AOAC Int. 77, 1689-1694 (1994)

129 Aswania, O.A., Corlett, S.A., Chrystyn, H., Development and validation of an ion-pair liquid chromatographic method for the quantification of sodium cromoglycate in urine following inhalation, J. Chrom. B Biomed. Sci. Appl. 690, 373-378 (1997)

130 Yoshimi, A., Hashizume, H., Kitagawa, M., Nishimura, K., Kakeya, N., Characteristics of 1,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)-lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits, Pharmacobiodyn. 15, 681-686 (1992)

131 List, P.H. (Hrsg.), Arzneiformenlehre: Ein Lehrbuch für Pharmazeuten, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1985, S. 442

132 Bommer, R., Latest advances in nasal drug-delivery technology, Med. Device Technol. 5, 22-28 (1999)

133 Siefert, B., Einfluß von Cyclodextrin auf die Löslichkeit und okulare Verfügbarkeit von Pilocarpin-HCl bzw. Thalidomid , Dissertation, Humboldt-Universität zu Berlin, Berlin, 1998

134 Leuenberger, H. (Hrsg.), Martin Physikalische Chemie, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 2002, S. 355 ff., 479 ff., 561 ff.

135 Uchida, N., Yoshie, M., Nakagaki, M., Nagai, T., Influence of bile salts on the permeability of insulin through the nasal mucosa of rabbits in comparison with dextran derivatives, Int. J. Pharm. 74, 95-103 (1991)

136 Berndt, S.M., Entwicklung und Charakterisierung galenischer Formulierungen zur potentiellen nasalen Anwendung von Androstendion und Levodopa , Dissertation, Humboldt-Universität zu Berlin, Berlin, 2000

137 Lang, S., Rothen-Rutishauser, B., Perriard, J.-C., Schmidt, M.C., Merkle, H.P., Permeation and pathways of human calcitonin (hct) across excised bovine nasal mucosa, Peptides 19, 599-607 (1998)

138 Batts, A.H., Mariott, G.P., Wood, C.F., Bond, S.W., The effect of some preservatives used in nasal preparations on the mucus and ciliar components of mucociliary clearance, J. Pharm. Pharmacol. 42, 145-151 (1990)

139 Reardon, P., Wall, A.D., Hart, T.K., Smith, P.L., Gochoco, C.H., Lack of effect of ammonium glycyrrhizinate on the morphology of ovine nasal mucosa in vitro, Pharm. Res.10 , 1301-1307 (1993)

140 Anderberg, E.K., Artursson, P., Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells, J. Pharm. Sci. 82, 392-398 (1993)

141 Clausen, A.E., Bernkop-Schnürch, A., Thiolated carboxymethylcellulose: In vitro evaluation of its permeation enhancing effect on peptide drugs, Eur. J. Pharm. Biopharm. 51, 25-32 (2001)

142 Lindmark, T., Kimura, Y., Artursson, P., Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells, J. Pharm. Exp. Ther. 284, 362-369 (1998)

143 Hussain, A.A., Mechanism of nasal absorption of drugs, Prog. Clin. Biol. Res. 314, 183-189 (1989)

144 Corbo, D.C., Lui, J.-C., Chien, Y.W., Drug absorption through mucosal membranes: Effect of mucosal route and penetrant hydrophilicity, Pharm. Res. 6, 848-852 (1989)

145 Hussain, A.A., Intranasal drug delivery, Adv. Drug Deliv. Rev. 29, 39-49 (1998)

146 Rojanasakul, Y., Wang, L.-Y., Bhat, M., Glover, D.D., Malanga, C.J., Ma, J.K.H., The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit, Pharm. Res. 9, 1029-1034 (1992)

147 Grass, G.M., Wood, R.W., Robinson, J.R., Effects of calcium chelating agents on corneal permeability, Invest. Opthal. Vis. Sci. 26, 110-113 (1985)

[Seite 161↓]

148 Liu, D.-Z., ElCluyse, E.L., Thakker, D.R., Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers, J. Pharm. Sci. 88, 1161-1168 (1999)

149 Kotze, A.F., Lueßen, H.L., de Boer, A.G., Junginger, H.E., Chitosan for enhanced intestinal permeability: Prospects for derivatives in neutral and basic environment, Eur. J. Pharm. Sci. 7, 145-151 (1998)

150 Quan, Y., Hattori, K., Lundborg, E., Fujita, T., Murakami, M., Muranishi, S., Yamamoto, A., Effectiveness and toxicity of various absorption enhancers using Caco-2 cell monolayers, Biol. Pharm. Bull. 21, 615-620 (1998)

151 Marttin, E., Verhoef, J.C., Romeijn, S.G., Zwart, P., Merkus, F.W.H.M., Acute histopathological effects of benzalkonium chloride and absorption enhancers on rat nasal epithelium in vivo, Int. J. Pharm. 141, 1 51-160 (1996)

152 Eichman, J.D., Robinson, J.R., Mechanistic studies on effervescent-induced permeability enhancement, Pharm. Res. 15, 925-930 (1998)

153 Donovan, M.D., Robinson, J.R., Amidon, G.L., The molecular weight dependence on nasal absorption: The effect of absorption enhancers, Pharm. Res. 7 , 808-815 (1990)

154 Wilson, C.G., Tomlinson, E., Davis, S.S., Olejnik, O., Altered ocular absorption and disposition of sodium cromoglycate upon ion-pair and complex formation with dodecylbenzyldimethylammonium chloride, J. Pharm. Pharmacol. 31, 749-753 (1981)

155 Pereswetoff-Morath, L., Edman, P., Influence of osmolarity on nasal absorption of insulin from the thermogelling polymer ethyl(hydroxyethyl)cellulose, Int. J. Pharm. 125, 205-213 (1995)

156 Suleymanian, M.A., Baumgarten, C.M., Osmotic gradient-induced water permeation across the sarcolemma of rabbit ventricular myocytes, J. Gen. Physiol. 107, 503-514 (1996)

157 Salomon, A.K., Water channels across the red blood cell and other biological membranes, Methods Enzymol. 173, 192-222 (1989)

158 Bjarnason, I., MacPherson, A., Hollander, D., Intestinal permeability: An overview, Gastroenterology 108, 1566-1581 (1995)

159 Voigt, R. (Hrsg.), Pharmazeutische Technologie, Deutscher Apotheker Verlag Stuttgart, 2000, S. 40 ff., 82 ff.

160 Romejin, S.G., Verhoef, C.J., Marttin, E., Merkus, F.W.H.M., The effect of nasal drug formulations on ciliary beating in vitro, Int. J. Pharm. 135, 137-145 (1996)

161 Maitani, Y., Uchida, N., Nakagaki, M., Nagai, T., Effect of bile salts on the nasal mucosa: membrane potential measurement, Int. J. Pharm. 69, 21-27 (1991)

162 Pohl, E.E., Krylov, A.V., Block, M., Pohl, P., Changes of membrane potential profile induced by verapamile and propranolol, Biochim. Biophys. Acta 1373, 170-178 (1998)

163 Natsume, H., Iwata, S., Ohtake, K., Miyamoto, M., Yamaguchi, M., Hosoya, K., Kobayashi, D., Sugibayashi, K., Morimoto, Y., Screening of cationic compounds as an absorption enhancer for nasal drug delivery, Int. J. Pharm. 185, 1-12 (1999)

164 Marttin, E., Verhoef, J.C., Romeijn, S.G., Merkus, F.W.H.M., Effects of absorption enhancer on rat nasal epithelium in vivo: Release of marker compounds in the nasal cavity, Pharm. Res. 12, 1151-1157 (1995)

165 Krishnamoorthy, R., Wolka, A.M., Shao, Z., Mitra, A.K., Cyclodextrins as mucosal absorption promotors. IV: Evaluation of nasal mucotoxicity, Eur. J. Pharm. Biopharm. 41, 296-301 (1995)

166 Aspden, T.J., Illum, L., Skaugrud, Ø ., Chitosan as a nasal delivery system: Evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models, Eur. J. Pharm. Sci. 4, 23-31 (1996)

167 Lowry, O.H., Rosenbrough, N.J., Farr, A.L., Randall, P.J., J. Biol. Chem. 193, 265 (1951)

168 Vejdelek, Z.J. (Hrsg.), Farbreaktionen in der spektrophotometrischen Analyse organischer Verbindungen, Gustav Fischer Verlag Jena, 1976

169 Schuppan, J., Theorie und Messmethoden in der Konduktometrie, Akademie-Verlag Berlin, 1980,S. 20 ff.

170 Glaser, R. (Hrsg.), Biophysik, Gustav Fischer Verlag Stuttgart, 1986, S.300 ff.

171 Karlson, P. (Hrsg.), Kurzes Lehrbuch der Biochemie für Mediziner und Naturwissenschaftler, Georg Thieme Verlag Stuttgart, 1988, S. 297 ff.

[Seite 162↓]

172 Cox, J.S.G., Woodward, G.D., McCrone, W.C., Solid-state chemistry of cromolyn sodium, J. Pharm. Sci. 60, 1458-1465 (1971)

173 Richter, H.J., Böhm, M. (Hrsg.), Pharmazeutisches Lexikon, Verlag Volk und Wissen Berlin, 1989

174 Bauer, K.H., Frömming, K.-H., Führer, C. (Hrsg.), Lehrbuch der Pharmazeutischen Technologie, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1999

175 Champion, J.V., Meeten, G.H., Conformation of sodium cromolyn in aqueous solution using light scattering and magnetic birefringence, J. Pharm. Sci. 62, 1589-1595 (1973)

176 Hamodrakas, S., Geddes, A.J., Sheldrick, B., X-ray analysis of disodium cromoglycate, J. Pharm. Pharmacol. 26, 54-56 (1974)

177 Saha, P., Kou, J.H., Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers, Eur. J. Pharm. Biopharm. 50, 403-411 (1990)

178 Attiga, S.A., Eley, D.D., Hey, M.J., A nuclear magnetic relaxation study of bound water in solutions of disodium cromoglycate, J. Pharm. Pharmacol. 31, 387-391 (1979)

179 Jepsen, M., Graham, S., Karp, P.H., Zabner, J., Effect of topical nasal pharmaceuticals on sodium and chloride transport by human airway epithelia, Am. J. Rhinol. 14, 405-409 (2000)

180 Lueßen, H.L., Leeuw, B.J., Langemeyer, M.W.E., de Boer, A.G., Verhoef, J.C., Junginger, H.E., Mucoadhesive polymers in peroral peptide drug delivery. IV: Carbomer and chitosan improve the intestinal absorption of the peptide drug burserelin in vivo, Pharm. Res. 13, 1668-1672 (1996)

181 Schipper, N.G.M., Verhoef, J., Romeijn, S.G., Merkus, F.W.H.M., Absorption enhancers in nasal insulin delivery and their influence on nasal ciliary functioning, J. Control. Release 21, 173-186 (1992)

182 Reardon, P., Gochoco, C.H., Audus, K.L., Wilson, G., Smith, P.L., In vitro nasal transport across ovine mucosa: Effects of ammonium glycyrrhizinate on electrical properties and permeability of growth hormone releasing peptide, mannitol and lucifer yellow, Pharm. Res. 10, 553-561 (1993)

183 Donovan, M.D., Flynn, G.L., Amidon, G.L., Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption, Pharm. Res. 7, 863-868 (1990)

184 Evrard, D., Touitou, E., Kolusheva, S., Fishov, Y., Jelinek, R., A new colorimetric assay for studying and rapid screening of membrane penetration enhancers, Pharm. Res. 18, 943-949 (2001)

185 Irwin, W.J., Dwivedi, A.K., Holbroock, P.A., Dey, M.J., The effect of cyclodextrins on the stability of peptides in nasal enzymatic systems, Pharm. Res. 11, 1698-1703 (1994)

186 Maitani, Y., Ishigaki, K., Takamura, K., Nagai, T., In vitro nasal transport across rabbit mucosa: Effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17-ß-estradiol, Int. J. Pharm. 146, 11-19 (1997)

187 Pahl, M.H. (Hrsg.), Praktische Rheologie der Elastomere und Kunststoffe, VDI-Verlag GmbH Düsseldorf, 1991, S. 10 ff., 136 ff.

188 Stettin, H., private Korrespondenz

189 Schramm, G. (Hrsg.), Einführung in Rheologie und Rheometrie, Gebrüder HAAKE GmbH Karlsruhe, 1995, S. 10 ff., 156 ff.

190 Metzger, T. (Hrsg.), Ein kleiner Rheologiekurs, PHYSIKA Messtechnik GmbH Stuttgart, 1992

191 Gehm, L. (Hrsg.), Rheologie, Vincentz Verlag Hannover, 1998, S. 29 ff. 45 ff.

192 Welin-Berger, K., Neelissen, J.A.M., Bergenstahl, B., The effect of rheological behaviour of a topical anaesthetic formulation on the release and permeation rates of the active compound, Eur. J. Pharm. Sci. 13, 103-111 (2001)

193 Ludwig, A., Van Oteghem, M., Evaluation of sodium hyaluronate as viscous vehicle for eye drops, J. Pharm. Belg. 13, 391-397 (1989)

194 Pritchard, K., Lansley, A.B., Martin, G.P., Helliwell, M., Marriott, C., Benedetti, L.M., Evaluation of the bioadhesive properties of hyaluronan derivatives: Detachment weight and mucociliary transport rate studies, Int. J. Pharm. 129, 137-145 (1996)

195 Ozsoy, Y., Tuncel, T., Can, A., Akev, N., Birteksoz, S., Gerceker, A., In vivo studies on nasal preparations of ciprofloxacin hydrochloride, Pharmazie 55, 607-609 (2000)

196 De Andres-Santos, A.I., Velasco-Martin, A., Hernandez-Velasco, E., Martin-Gil, J., Martin-Gil, F.J., Thermal behaviour of aqueous solutions of sodium hyaluronate from different commercial sources, Thermoch. Acta 242, 153-160 (1994)

197 Produktinformation Pronova Biopolymer, Norderstedt

[Seite 163↓]

198 Larhed-Wikman, A., Artursson, P., Grasjö, B., Björk, E., Diffusion of drugs in native and purified gastrointestinal mucus, J. Pharm. Sci. 86, 660-665 (1997)

199 Bhat, P.G., Flanagan, M.D., The limitating role of mucus in drug absorption: Drug permeation through mucus solution, Int. J. Pharm. 126, 179-187 (1995)

200 Keipert, S., Fedder, J., Böhm, A., Hanke, B., Interactions between cyclodextrins and pilocarpine – As an example of a hydrophilic drug, Int. J. Pharm. 142, 153-162 (1996)

201 Passali, D., Bellussi, L., Lauriello, M., The rheological characteristics of nasal mucus in patients with rhinitis, Eur. Arch. Otorhinolaryngol. 252, 348-352 (1995)

202 Batts, A.H., Mariott, C., Martin, G.P., Bond, S.W., The effect of some preservatives used in nasal preparations on mucociliary clearance, J. Pharm. Pharmacol. 41, 156-159 (1988)

203 Stoll, A.J., The effect of antiallergic intranasal formulations on ciliary beat frequency of human nasal epithelium in vitro, Allergy 53, 986-989 (1998)

204 Hermens, W.A.J.J., Merkus, F.W.H.M., Nasale Arzneimittel: Der Einfluß von Arzneimitteln auf die Bewegung nasaler Flimmerhaare, DAZ 130, 2411-2415 (1990)

205 Saketkhoo, K., Yergin, B.M., Januszkiewicz, A., Kovitz, K., Sackner, M.A., The effect of nasal decongestants on nasal mucus velocity, Am. Rev. Resp. Dis. 118, 251-254 (1978)

206 Morimoto, K., Yamaguchi, H., Iwakura, Y., Morisaka, K., Ohashi, Y., Nakai, Y., Effects of viscous hyaluronate-sodium solutions on the nasal absorption of vasopressin and an analogue, J. Pharm. Pharmacol. 37, 134-136 (1991)

207 Pereswetoff-Morath, L., Bjurstrom, S., Khan, R., Dahlin, M., Edmann, P., Toxilogical aspects of the use of dextran microspheres and thermogelling(hydroxyethyl)cellulose (EHEC) as nasal drug delivery systems, Int. J. Pharm. 128, 9-21 (1996)

208 Su, X.Y., Mattern, C., Häcker, R., Li Wan Po, A., Does sea-water made isotonic affect ciliary beat frequency?, Int. J. Pharm. 123, 47-51 (1995)

209 Hermens, W.A.J.J., Merkus, F.W.H.M., Nasale Arzneimittel: Der Einfluss von Arzneimitteln auf die Bewegung nasaler Flimmerhaare, DAZ 130, 2411-2415 (1990)

210 Van de Donk, H.J.M., Heuvel, A.G.M., Zuidema, J., Merkus, F.W.H.M., The effects of nasal drops and their additive on human nasal mucociliary clearance, Rhinology 20, 127-137 (1982)

211 Leone-Bay, A., Leipold, H., Sarubbi, D., Variano, B., Rivera, T., Baughman, R.A., Oral delivery of sodium cromolyn: Preliminary studies in vivo and in vitro, Pharm. Res. 13, 222-226 (1996)

212 Aswania, O.A., Corltt, S.A., Chrystyn, H., Relative bioavailability of sodium cromoglycate to the lung following inhalation, using urinary excretion, Br. J. Clin. Pharmacol. 47, 613-618 (1999)

213 Lee, V.H.-L., Swarbrick, J., Stratford, R.E., Morimoto, K.W., Disposition of topically applied sodium cromoglycate in the albino rabbit eye, J. Pharm. Pharmacol. 35, 445-450 (1983)

214 Fisher, A.N., Brown, K., Davis, S.S., Parr, G.D., Smith, D.A., The nasal absorption of sodium cromoglycate in the albino rat, J. Pharm. Pharmacol. 37, 38-41 (1985)

215 Mayor, S.H., Illum, L., Investigation of the effect of anaesthesia on nasal absorption of insulin in rats, Int. J. Pharm. 149, 123-129 (1997)

216 Illum, L., Farraj, N.F., Davis, S.S., Johansen, B.R., Davis, S.S., Investigation of the nasal absorption of biosynthetic human growth hormone in sheep: Use of a bioadhesive microsphere delivery system, Int. J. Pharm. 63, 207-211 (1990)

217 Wolff, R.K., Allen, D.L., Hughes, B.L., Osier, M., Dorato, M.A., Nasal clearance in rhesus monkeys, J. Aerosol. Med. 6, 111-119 (1993)

218 Pfeifer, S., Pflegel, P., Borchert, H.-H. (Hrsg.), Biopharmazie, Ullstein/Mosby GmbH & CoKg Berlin, Wiesbaden, 1995, S. 87 ff.

219 Kato, Y., Muraki, K., Fujitaka, M., Sakura, N., Ueda, K., Disodium cromoglycate use in children and adolescents with asthma: Correlation between plasma concentrations and protective effects for various inhalation methods, Ann. Allergy Asthma Immunol. 83, 553-558 (1999)

220 Dolder, R. (Hrsg.), Ophthalmika, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1990, S. 243-244

221 Greaves, J.L., Wilson, C.G., Treatment of diseases of the eye with mucoadhesive delivery systems, Adv. Drug Del. Rev. 11, 349-383 (1993)

222 Snibson, G.R., Greaves, J.L., Soper, J.L., Prydal, J.I., Wilson, C.G., Bron, A.T., Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy, Eye 4, 594-602 (1990)

[Seite 164↓]

223 Snibson, G.R., Greaves, J.L., Soper, B., Tiffany, J.M., Wilson, C.G., Bron, A.T., Ocular surface residence times of artificial tear solutions, Cornea 11, 288-293 (1992)

224 Saettone, M.F., Chetoni, P., Torracca, M.T., Burgalassi, S., Giannaccini, B., Evaluation of mucoadhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid, Int. J. Pharm. 51, 203-212 (1989)

225 Kano, S., Hirose, T., Nishima, S., Change in osmolarity of disodium cromoglycate solution and protection against exercise-induced bronchospasm in children with asthma, Eur. J. Respir. 9, 1891-1895 (1996)

226 Aspden, T., Illum, L., Skaugrud, Ø., The effect of chronic nasal application of chitosan solutions on cilia beat frequency in guinea pigs, Int. J. Pharm. 153, 137-146 (1997)

227 Hardy, J.G., Lee, S.W., Wilson, C.G., Intranasal drug delivery by spray and drops, J. Pharm. Pharmacol. 37, 294-297 (1985)

228 Hagers Handbuch der Pharmazeutischen Praxis, Band 2, Methoden, Springer-Verlag Berlin, Heidelberg, 1993, S. 761

229 Lechner, M.D. (Hrsg.), D’Ans Lax – Taschenbuch für Chemiker und Physiker, Band 1, Physikalisch-chemische Daten, Springer-Verlag Berlin, Heidelberg, 1992, S. 476

230 Jones, M.-C., Leroux, J.C., Polymeric micelles - A new generation of colloidal drug carriers, Eur. J. Pharm. Biopharm. 48, 101-111 (1999)

231 Golander, Y., De Witte, W.J., Analytical profiles of drug substances 14, 1985, S. 135 ff.

232 Siebenbrodt, I., Untersuchungen zur Verfügbarkeitsoptimierung von Ophthalmika , Dissertation, Humboldt-Universität zu Berlin, Berlin, 1990

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