Charakterisierung rekombinanter immunreaktiver Antigene der Krätzmilbe Sarcoptes scabiei Carola Kuhn1111.11.1.11.1.212603#377131.1.3141.1.4151.1.5161.21.317181.4191.4.11.4.22021221.4.3231.51.5.1241.5.21.5.3251.6261.7271.8282292.12.1.12.1.2302.1.32.1.4312.1.532332.1.6342.1.72.1.835362.1.9372.1.10382.1.112.1.11.12.1.11.22.1.11.32.1.12392.1.12.12.1.12.22.1.12.3402.1.12.4412.1.12.5422.1.12.62.1.12.72.1.12.82.1.12.9432.1.12.102.1.12.11442.1.12.122.1.12.13452.1.12.142.1.12.152.1.12.16462.1.12.172.1.12.18472.2482.2.12.2.1.12.2.1.22.2.1.32.2.2492.2.2.12.2.2.2502.2.2.32.2.2.42.2.2.5512.2.2.6522.2.2.72.2.2.7.1532.2.2.7.22.2.2.7.3542.2.2.7.42.2.2.7.52.2.2.7.6552.2.2.8562.2.2.92.2.2.102.2.2.11572.2.2.11.12.2.2.11.22.2.2.122.2.2.13582.2.2.14592.2.2.152.2.2.16602.2.2.172.2.2.18612.2.2.192.2.2.20622.2.2.212.2.2.22632.2.2.232.2.2.23.12.2.2.23.2642.2.2.23.2.12.2.2.23.3652.2.2.23.42.2.2.23.4.12.2.2.23.4.2662.2.2.242.2.2.252.2.2.25.1672.2.2.25.22.2.2.262.2.2.27682.2.2.27.12.2.2.27.22.2.2.27.3692.2.2.28702.2.3712.2.3.12.2.3.22.2.3.3722.2.3.42.2.4732.2.4.12.2.4.274752.2.4.3762.2.4.42.2.4.4.12.2.4.4.22.2.4.4.3772.2.4.4.42.2.4.5782.2.4.62.2.4.6.12.2.4.6.2792.2.4.6.32.2.4.7802.2.4.82.2.4.92.2.4.9.1812.2.4.9.2822.2.4.9.32.2.4.9.42.2.4.9.5832.2.53843.1616#2083.285556#2113.3863.4325#2003.587604#3193.6883.73.7.1603#1773.88990603#273913.9923.9.13.9.1.1560#34393553#8853.9.1.29495528#88696603#3453.9.1.39798532#88599552#3923.9.1.43.9.1.4.1100603#253101540#885102583#3613.9.21033.9.2.1604#73104548#885105579#3443.9.2.2106604#129107559#885108487#3453.9.2.3109603#208110556#8861113.9.2.43.9.2.4.1337#2773.9.2.4.2112113603#493114115604#8373.9.2.4.3116117551#8853.9.2.4.41183.9.2.4.5603#137119603#3353.9.2.4.6120491#4091213.9.2.4.7368#4553.9.2.4.81223.9.2.4.8.1123124575#3633.9.2.4.8.21253.9.2.4.8.2.13.9.2.4.8.2.23.9.2.4.8.2.31263.9.2.4.8.2.4127603#638128581#679603#2881293.103.10.1130608#248560#2093.10.2131608#248132547#2093.10.3133552#221552#2053.10.4134608#243135608#245553#199136544#2153.10.5137608#244551#2103.10.6138609#244139560#2213.10.7140608#235559#220141613#61741424.11434.21441454.31461474.41481491504.51511521531541551561571581594.61604.6.11611624.6.21631645165 Literatur166167168169170171172173174175176177178179180181182183184 Abkürzungsverzeichnis185186 Symbole für Aminosäuren187Buchstabencode mehrdeutiger Nukleotide (Wobbles)Sequenzen der charakterisierten Klone603#591603#480604#613603#513603#459603#415603#424603#646603#724DanksagungLebenslaufdeInhaltsverzeichnisHilfe Literatur ADAM, R., B. KALTMANN, W. RUDIN, T. FRIEDRICH, T. MARTI und R. LUCIUS (1996): Identification of chitinase as the immunodominant filarial antigen recognized by sera of vaccinated rodents. J. Biol. Chem. 271 (3), S. 1441-1447. ADLER, B. K., M. E. HARRIS, K. I. BERTRAND und S. L. HAJDUK (1991): Modification of Trypanosoma brucei Mitochondrial rRNA by Posttranscriptional 3´ Polyuridine Tail Formation. Mol. Cel. Biol. 11 (12), S. 5878-5884 ALONSO DE VEGA, F., J. MENDEZ DE VIGO, J. ORTIZ SANCHEZ, C. MARTINEZ-CARRASCO PLEITE, A. ALBALADEJO SERRANO und M. R. RUIZ DE YBANEZ CARNERO (1998): Evaluation of the prevalence of sarcoptic mange in slaughtered fattening pigs in southeastern Spain. Vet. Parasitol. 76 (3), S. 203-209 ANDERS, R. F. (1986): Multiple cross-reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria. Parasite Immunol. 8 (6), S. 529-539 ARENDS, J. J., C. M. STANISLAW und D. GERDON (1990): Effects of sarcoptic mange on lactating swine and growing pigs. J. Anim. Sci. 68 (6), S. 1495-1499 ARLIAN, L. G., D. L. VYSZENSKI-MOHER und A. M. GILMORE (1988): Cross-Antigenicity Between Sarcoptes scabiei and the House Dust Mite, Dermatophagoides farinae (Acari: Sarcoptidae and Pyroglyphidae). J. Med. Entomol. 25 (4), S. 240-247. ARLIAN, L. G., D. L. VYSZENSKI-MOHER und M. J. POLE (1989): Survival of adults and development stages of Sarcoptes scabiei var. canis when off the host. Exp. Appl. Acarol. 6, S. 181-187 ARLIAN, L. G., D. L. VYSZENSKI-MOHER, S. G. AHMED und S. A. ESTES (1991): Cross-antigenicity between the scabies mite, Sarcoptes scabiei, and the house dust mite, Dermatophagoides pteronyssinus. J. Invest. Dermatol. 96 (3), S. 349-54 AR LIAN, L. G., D. BERNSTEIN, I. L. BERNSTEIN, S. FRIEDMAN, A. GRANT, P. LIEBERMAN, M. LOPEZ, J. METZGER, T. PLATTS-MILLS und M. SCHATZ (1992): Prevalence of dust mites in the homes of people with asthma living in eight different geographic areas of the United States. J. Allergy Clin. Immunol. 90 (3 Pt 1), S. 292-300 ARLIAN, L. G., C. M. RAPP, D. L. VYSZENSKI-MOHER und M. S. MORGAN (1994a): Sarcoptes scabiei: Histopathological Changes Associated with Acquisition and Expression of Host Immunity to Scabies. Exp. Parasitol. 78 (1), S. 51-63 ARLIAN, L. G., M. S. MORGAN, D. L. VYSZENSKI-MOHER und B. L. STEMMER (1994b): Sarcoptes scabiei: The Circulating Antibody Response and Induced Immunity to Scabies. Exp. Parasitol. 78 , S. 37-50 ARLIAN, L. G., C. M. RAPP und M. S. MORGAN (1995): Resistance and immune response in Scabies-infested hosts immunized with Dermatophagoides mites. Am. J. Trop. Med. Hyg. 52 (6), S. 539-545 ARLIAN, L. G. (1996): Immunology of scabies. Wikel, S. K. ed., in: The Immunology of Host-Ectoparasitic Arthropod Relationships. Wallingford, UK: CAB International, S. 232-257 ARLIAN, L. G., M. S. MORGAN und J. J. ARENDS (1996a): Immonologic cross-reactivity among various strains of Sarcoptes scabiei. J. Parasitol. 82 (1), S. 66-72 ARLIAN, L. G., M. S. MORGAN, C. M. RAPP, und D. L. VYSZENSKI-MOHER (1996b): The development of protective immunity in canine scabies. Vet. Parasitol. 62 (1-2), S. 133-142 ARLIAN, L. G., D. L. VYSZENSKI-MOHER, C. M. RAPP und B. A. HULL (1996c): Production of IL-1 α und IL-1 β by human skin equivalents parasitized by Sarcoptes scabiei. J. Parasitol. 82 (5), S. 719-723 ARLIAN, L. G. und M. S. MORGAN (2000 ): Serum antibody to Sarcoptes scabiei and house dust mite prior to and during infestation with S. scabiei. Vet. Parasitol. 90 (4), S. 315-326 ARLIAN, L. G. (2002): Arthropod allergens and human health. Annu. Rev. Entomol. 47, S. 395-433 ARLIAN, L. G., M. S. MORGAN und J. S. NEAL (2003): Modulation of cytokine expression in human keratinocytes and fibroblasts by extracts of scabies mites. Am. J. Trop. Med. Hyg. 69 (9), S. 652-656 ARLIAN, L. G., M. S. MORGAN, S. A. ESTES, S. F. WALTON, D. J. KEMP und B. J. CURRIE (2004): Circulating IgE in Patients with Ordinary and Crusted Scabies . J. Med. Entomol. 41 (1), S. 74-77 BEGHETTO, E., A. PUCCI, O. MINENKOVA, A. SPADONI, L. BRUNO, W. BUFFOLANO, D. SOLDATI, F. FELICI und N. GARGANO (2001 ): Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries . Int J. Parasitol. 31 (14), S. 1659-1668 BERRILLI, F., S. D´AMELIO und L. ROSSI (2002): Ribosomal and mitochondrial DNA sequence variation in Sarcoptes mites from different hosts and geographical regions. Parasitol. Res. 88 (8), S. 772-777 BEZOLD, G., M. LANGE, R. SCHIENER, G. PALMEDO, C. A. SANDER, M. KERSCHER und R. U. PETER (2001): Hidden scabies: diagnosis by polymerase chain reaction. Br. J. Dermatol. 144 (3), S. 614-618 BORNSTEIN, S. und P. WALLGREN (1997): Serodiagnosis of sarcoptic mange in pigs. Vet. Rec. 141 (1), S. 8-12 BOIX, V., J. SANCHEZ-PAYA, J. PORTILLA und E. MERINO (1997 ): Nosocomial outbreak of scabies clinically resistant to lindane. Infect. Control Hosp. Epidemiol. 18 (10), S. 677 BÖCK, P. (Hrsg.) (1989): Schnellfärbung von Semidünnschnitten. in: Romeis Mikroskopische Techniken. Urban & Schwarzenberg München-Wien-Baltimore, 17. Aufl., S. 247-249 BRADLEY, J. E., R. HELM, M. LAHAISE und R. M. MAIZELS (1991): cDNA clones of Onchocerca volvulus molecular weight antigens provide immunologically specific diagnostic probes. Mol. Biochem. Parasitol. 46 (2), S. 219-228 BRENNAN, C. M. und J. A. STEITZ (2001): HuR and mRNA stability. Cell. Mol. Life Sci. 58 (2), S. 266-277 BROOKS, P. und R. F. GRACE (2002): Ivermectin is better than benzyl benzoate for childhood scabies in developing countries. J. Pediatr. Child Health 38, S. 401-404 BUFFET, M. und N. DUPIN (2003): Current treatments for scabies. Fundam. Clin. Pharmacol. 17 (2), S. 217-225 BURGESS, I. (1994): Sarcoptes scabiei and Scabies. Adv. Parasitol. 33, S. 235-292 CARTEGNI, L., S. L. CHEW und A. R. KRAINER (2002): Listening to silence and understanding nonsense: exonic mutation that affect splicing. Nat. Rev. Genet. 3 (4), S. 285-298 CATMULL, J., D. ZHANG, F. RUGGIERO, D. B. COPEMAN und D. J. MILLER (1994): Identification and characterisation of a novel repetitive antigen from Onchocerca. spp.. Mol. Biochem. Parasitol. 63 (1), S. 49-57 CHAHAN, B., I. GATURAGA, X. HUANG, M. LIAO, S. FUKUMOTO, H. HIRATA, Y. NISHIKAWA, H. SUZUKI, C. SUGIMOTO, H. NAGASAWA, K. FUJISAKI, I. IGARASHI, T. MIKAMI und X. XUAN (2003): Serodiagnosis of Neospora caninum in cattle by enzyme-linked immunosorbant assay with recombinant truncated NcSAG1. Vet. Parasitol. 118 (3-4), S. 177-185 CHAPMAN, M. D., A. M. SMITH, L. D. VAILES, K. ARRUDA, V. DHANARAJ und A. POMES (2000): Recombinant allergens for diagnosis and therapy of allergic disease. J. Allergy Clin. Immunol. 106 (3), S. 409-418 CHOSIDOW, O. (2000): Scabies and pediculosis. Lancet 355 (9206), S. 819-826 CHO-NGWA, F., M. AKOACHERE und V. P. K. TITANJI (2003): Sensitive and specific serodiagnosis of river blindness using Onchocerca ochengi antigens. Act. Tropica 89 (1), S. 25-32 CHUNG, Y.Y.Y. und R. C. KO (1999): A novel cDNA clone encoding a specific excretory/secretory antigen of larval Trichinella pseudospiralis. Parasitol. Res. 85 (8-9), S. 685-691 CORNELISSEN, J. B. W. J., C. P. H. GAASENBEEK, F. H. M. BORGSTEEDE, W. G. HOLLAND, M. M. HARMSEN und W. J. A. BOERSMA (2001): Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease. Int. J. Parasitol. 31 (7), S. 728-737 CURRIE, B. J., C. M. CONNORS und V. L. KRAUSE (1994): Scabies programs in Aboriginal communities. Med. J. Aust. 161 (10), S. 636-637 CURRIE, B. J. und J. R. CARAPETIS (2000): Skin infections and infestations in Aboriginal communities in northern Australia. Australas. J. Dermatol., 41 (3), S. 139-143 CURRIE, B. J., P. HARUMAL, M. MCKINNON und S. F. WALTON (2004): First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei. Clin. Infect. Dis. 39 (1), S. 8-12 CURTIS, C. F. (2001): Evaluation of a commercially available enzyme-linked immunosorbant assay for the diagnosis of canine sarcoptic mange. Vet. Rec. 148 (8), S. 238-239 DALTON, J. P., P. J. BRINDLEY, D. P. KNOX, C. P. BRADY, P. J. HOTEZ, S. DONNELLY, S. M. O´NEILL, G. MULCAHY und A. LOUKAS (2003): Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression. Int. J. Parasitol. 33 (5-6), S. 621-640 DAVIES, P. R., P. B. BAHNSON, J. J. GRASS, W. E. MARSH, R. GARCIA, J. MELANCON und G. D. DIAL (1996): Evaluation of the monitoring of papular dermatitis lesions in slaughtered swine to assess sarcoptic mite infestation. Vet. Parasitol. 62 (1-2), S. 143-153 DAVIS, D. P. und R. D. MOON (1990 ): Dynamics of Swine Mange: A Critical Review of the Literature. J. Med. Entomol. 27 (5), S. 727-737 ELGART, M. L. (1996): A risk-benefit assessment of agents used in the treatment of scabies. Drug Saf. 14 (6), S. 386-393 ELGART, M. L. (1999): Current treatments for scabies and pediculosis. Skin Therapy Lett. 5 (1), S. 1-3 ELMOGY, M., H. FAYED, H. MARZOK und A. RASHAD (1999): Oral ivermectin in the treatment of scabies. Int. J. Dermatol 38 (12), S. 926-928 EVANS, G. O. (1992): Reproductive Systems. in: Principles in Acarology CAB International, University Press, Cambridge, S. 263-298 FISCHER, K., D. HOLT, P. HARUMURAL, B. J. CURRIE, S. F. WALTON und D. J. KEMP (2003): Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens. Am. J. Trop. Med. Hyg. 68 (1), S. 61-64 FONG, M.-Y. und Y.-L. LAU (2004): Recombinant expression of the larval excretory-secretory antigen TES-120 of Toxocara canis in the methylotrophic yeast Pichia pastoris. Parasitol. Res. 92 (2), S. 173-176 FROHMAN, M. A., M. K. DUSH und G. R. MARTIN (1988): Rapid production of full-length cDNAs from rare transcripts: amplification using single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85 (23), S. 8998-9002 GALLIN, M. Y., M. TAN, M. A. KRON, D. RECHNITZER, B. M. GREENE, H. S. NEWLAND, A. T. WHITE, H. R. TAYLOR und T. R. UNNASCH (1989): Onchocerca volvulus recombinant antigen; physical characterisation and clinical correlates with serum reactivity. J. Infect. Dis. 160 (3), S. 521-529 GASSEN, H. G. und G. SCHRIMPF (2002): Gelelektrophoresen. in Gentechnische Methoden. Spektrum Akademischer Verlag Gustav Fischer, S. 19-71 DE GRAAF, D. C., P. BERGHEN, H. HILDERSON, H. DE COCK und J. VERCRUYSSE (1993): Identification and purification of Cooperia oncophora-specific antigens to improve serological diagnosis. Int. J. Parasitol. 23 (1), S. 141-144 GUTIÉRREZ, J. F., J. MENDEZ DE VIGO, J. CASTELLÁ, E. MUNOZ und D. FERRER (1996): Prevalence of sarcoptic mange in fattening pigs sacrified in a slaughterhouse of northeastern Spain. Vet. Parasitol. 61 (1-2), S. 145-149 HAJDUK, S. L., B. ADLER, S. MADISON-ANTENUCCI, M. MCMANUS und R. SABATINI (1997): Insertional and deletional RNA editing in trypanosome mitochondria. Nucleic Acids Symp. Ser. 36, S. 15-18 HARRIS, M. E., D. R. MOORE und S. L. HAJDUK (1990): Addition of Uridines to Edited RNAs in Trypanosome Mitochondria Occurs Independently of Transcription. J. Biol. Chem. 265 (19), S. 11368-11376 HARUMAL, P., M. MORGAN, S. F. WALTON, D. C. HOLT, J. RODE, L. G. ARLIAN, B. J. CURRIE und D. J. KEMP (2003 ): Identification of a homologue of a house dust mite allergen in a cDNA library from Sarcoptes scabiei var. hominis and evaluation of its vaccine potential in a rabbit/S. scabiei var. canis model. Am. J. Trop. Med. Hyg. 68 (1), S. 54-60 HEAD, S. E., E. M. MACDONALD, A. EWERT und P. APISARNTHANARAX (1990): Sarcoptes scabiei in Histopathologic Sections of Skin in Human Scabies. Arch. Dermatol. 126 (11), S. 1475-1476 VAN DER HEIJDEN, H. M. J. F., P. G. M. RAMBAGS, A. R. W. ELBERS, C. VAN MAANEN und W. A. HUNNEMANN (2000): Validation of ELISAs for the detection of antibodies to Sarcoptes scabiei in pigs. Vet. Parasitol. 89 (1-2), S. 94-107 HOFFMANN, A., S. VIETHS und D. HAUSTEIN (1997): Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction. J. Allergy Clin. Immunol. 99 (2), S. 227-232 HOLLANDERS, W., J. VERCRUYSSE, S. RAES und S. BORNSTEIN (1997): Evaluation of an immunosorbant assay (ELISA) for the serological daignosis of sarcoptic mange in swine. Vet. Parasitol. 69 (1-2), S. 117-123 HOLT, D. C., K. FISCHER, G. E. ALLEN, P. WILSON, R. SLADE, B. J. CURRIE, S. F. WALTON und D. J. KEMP (2003): Mechanisms for a Novel Immune Evasion Strategy in the Scabies Mite Sarcoptes scabiei: A Multigene Family of Inactivated Serine Proteases. J. Invest. Derm. 121 (6), S. 1419-1424 HOLT, D.C., K. FISCHER S.J. PIZZUTTO, B.J. CURRIE, S.F. WALTON und KEMP D.J. (2004): A multigene family of inactivated cysteine proteases in Sarcoptes scabiei. J. Invest. Dermatol. 123 (1), S. 240-241 IAROVAIA, O., S. V. RAZIN, G. LINARES-CRUZ, N. SJAKSTE und K. SCHERRER (2001): In Chicken Leukemia Cells Globin Genes Are Fully Transcribed but Their RNAs Are Retained in the Perinucleolar Area. Exp. Cell Res. 270 (2), S. 159-165 INOUE, H., H. NOJIMA und H. OKAYAMA (1990): High efficiency transformation of Escherichia coli with plasmids. Gene 96 (1), S. 23-28 JACOBSON, M., S. BORNSTEIN und P. WALLGREN (1999): The efficacy of simplified eradication strategies against sarcoptic mange mite infections in swine herds monitored by an ELISA. Vet. Parasitol. 81 (3), S. 249-258 JACOBSON, M., S. BORNSTEIN, E. PALMER und P. WALLGREN (2000): Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. Acta Vet. Scand. 41 (3), S. 227-235 KAMBARAGE, D. M., P. MSOLLA und J. FALMER-HANSEN (1990): Epidemiological studies of Sarcoptic mange in Tanzanian pig herds. Trop. Anim. Hlth. Prod. 22, S. 226-230 KATENDE, J., S. MORZARIA, P. TOYE, R. SKILTON, V. NENE, C. NKONGE und A. MUSOKE (1998): An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule. Parasitol. Res. 84 (5), S. 408-416 KEATING, K. M., D. B. SEGAL, S. J. CRAIG, A. K. NAULT, V. SEMENSI, A. S. WASSERMAN, C. M. COUNSELL und J. F. BOND (1995): Enhanced immunoreactivity and preferential heterodimer formation of reassociated Fel d I recombinant chains. Mol. Immunol. 32 (4), S. 287-293 KESSLER, E., H.-F. MATTHES, E. SCHEIN und M. WENDT (2003): Detection of antibodies in sera of weaned pigs after contact infection with Sarcoptes scabiei var. suis and after treatment with an antiparasitic agent by three different indirect ELISAs. Vet. Parasitol. 114 (1), S. 63-73 KIM, Y. M., H. A. HWANG., W. S. YUN, S. KIM, K. W. LEE, S. K. PARK, Y. J. LEE, T. K. KIM, C. WONGSRICHANALAI, J. A. SAKANARI und H. PARK (2004): Efficacy of the Merozoite Surface Protein 1 of Plasmodium Vivax as an Antigen for ELISA to Diagnose Malaria. Yonsei Med. J. 45 (1), S. 129-134 KIMBITA, E. N., X. XUAN, X. HUANG, T. MIYAZAWA, S. FUKUMOTO, M. MISHIMA, H. SUZUKI, C. SUGIMOTO, H. NAGASAWA, K. FUJISAKI, N. SUZUKI, T. MIKAMI und I. IGARASHI (2001): Serodiagnosis of Toxoplasma gondii infection in cats by enzyme-linked immunosorbent assay using recombinant SAG1. Vet. Parasitol. 102 (1-2), S. 35-44 KLION, A. D., A. VIJAYKUMAR, T. OEI, B. MARTIN und T. B. NUTMAN (2002): Serum Immunoglobin G4 Antibodies to the Recombinant Antigen, Ll-SXP-1, Are Highly Specific for Loa loa Infection. J. Infect. Dis. 187 (1), S. 128-33 KUMARI, S., C. D. LILLIBRIDGE, M. BAKEER, R. C. LOWRIE Jr., K. JAYARAMAN und M. T. PHILIPP (1994): Brugia malayi: the diagnostic potential of recombinant excretory/secretory antigens. Exp. Parasitol. 79 (4), S. 489-505 LAEMMLI, U. K. (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (5259), S. 680-685 LALLI, P. N., M. S. MORGAN und L. G. ARLIAN, (2004): Skewed Th1/Th2 immune response to Sarcoptes scabiei. J. Parasitol. 90 (4), S. 711-714 LEE, A. J., J. MACHELL, A. H. M. VAN DEN BROEK, A. J. NISBET, H. R. P. MILLER, R. E. ISAAC und J. F. HUNTLEY (2002): Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens. Parasite Immunol. 24 (8), S. 413-422 LIGHTOWLERS, M. W. und M. D. RICKARD (1988): Excretory-secretory products of helminth parasites: effects on host immune responses. Parasitology 96 Suppl., S. 123-166 LJUNGGREN E. L., D. NILSSON und J. G. MATTSSON (2003): Expressed sequence tag analysis of Sarcoptes scabiei. Parasitology 127 (2), S. 139-145 LOBOS, E., M. ALTMAN, G. MENGOD, N. WEISS, W. RUDIN und M. KARAM (1990): Identification of an Onchocerca volvulus cDNA encoding a low-molecular weight antigen uniquely recognised by onchocerciasis patient sera. Mol. Biochem. Parasitol. 39 (1), S. 135-145 LORENZO, S., F. ROMARÍS, R. IGLESIAS, M. T. AUDÍCANA, J. M. ALONSO, J. LEIRO und F. M. UBEIRA (2000): O-glycans as a source of cross-reactivity in determinations of human serum antibodies to Anisakis simplex antigens. Clin. Exp. Allergy 30 (4), S. 551-559 LOTTSPEICH, F. und H. ZORBAS (1998): Immunologische Techniken. in Bioanalytik. Spektrum Akademischer Verlag, S. 68-102. LOWER, K. S., L. M. MEDLEAU, K. HNILICA und B. BIGLER (2001): Evaluation of an enzyme-linked immunosorbant assay (ELISA) for the serological diagnosis of sarcoptic mange in dogs. Vet. Dermatol. 12 (6), S. 315-320 LÖWENSTEIN, M., H. KAHLBACHER und R. PESCHKE (2004): On the substantial variation in serological responses in pigs to Sarcoptes scabiei var. suis using different commercially available indirect enzyme-linked immunosorbant assays. Parasitol. Res. 96 (1), S. 24-30 LUCIUS, R., A. KERN, F. SEEBER, T. POGONKA, J. WILLENBUCHER, H. R. TAYLOR, M. PINDER, H. W. GHALIB, H. SCHULZ-KEY und P. SOBOSLAY (1992): Specific and sensitive IgG4 immunodiagnosis of onchocerciasis with a recombinant 33 kD Onchocerca volvulus protein (Ov33). Trop. Med. Parasitol. 43 (3), S. 139-145 MATTHES, H.-F., K. NÖCKLER und T. HIEPE (1992 ): Immunreaktionen bei Sarcoptes-Infektionen. Nova Acta Leopoldina NF 68 (283), S. 119-129 MATTHES, H.-F., G. B. L. HARRISON, R. J. SHAW, A. C. G. HEATH, A. PFEFFER und T. H. HIEPE (1996): Cross-reacting Antibodies to Sarcoptes suis, Chorioptes bovis and Notoedres cati and anti-P. ovis IgE in Sera from Sheep Infested Naturally with Psoroptes ovis. Int. J. Parasitol 26 (4), S. 437-444 MATTSSON, J. G., E. L. LJUNGGREN und K. BERGSTRÖM (2000): Paramyosin from the parasitic mite Sarcoptes scabiei: cDNA cloning and heterologous expression. Parasitology 122 (5), S. 555-562 MCCARTHY, J. S., D. J. KEMP, S. F. WALTON und B. J. CURRIE (2004): Scabies: more than just an irritation. Postgrad. Med. J. 80 (945): 382-387 MEINKING, T. L., D. TAPLIN, J. L. HERMINDA, R. PARDO und F. A. FRANCISCO (1995): The Treatment of Scabies with Ivermectin. N. Engl. J. Med. 333 (1), S. 26-30 MEINKING, T. L. und G. W. ELGART (2000): Scabies Therapy for the Millennium. Pediatr. Dermatol. 17 (2), S. 154-156 MEIRA, W. S. F., L. M. C. GALVAO, E. D. GONTIJO, G. L. L. MACHADO-COELHO, K. A. NORRIS und E. CHIARI (2002): Trypanosoma cruzi Recombinant Complement Regulatory Protein: a Novel Antigen for Use in an Enzyme-Linked Immunosorbant Assay for Diagnosis of Chagas´ Disease. J. Clin. Microbiol. 40 (10), S. 3735-3740 MELLANBY, K. (1944): The development of symptoms, parasitic infestation and immunity in human scabies. Parasitology 35, S. 197-206 MIGNONE, F., C. GISSI, S. LIUNI und G. PESOLE (2002): Untranslated regions of mRNA. Genome Biol. 3 (3), S. 1-10 MOLINARI, J. L., E. GARCÍA-MENDOZA, Y. DE LA GARZA, J. A. RAMÍREZ, J. SOTELO und P. TATO (2002): Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an Enzyme-Linked Immunosorbent Assay. Am. J. Trop. Med. Hyg. 66 (6), S. 777-781 MORGAN, M. S., L. G. ARLIAN und S. A. ESTES (1997): Skin test and radioallergosorbent test characteristics of scabietic patients. Am. J. Trop. Med. Hyg. 57 (2), S. 190-196 MORSY, G. H. und S. M. GAAFAR (1989): Responses of immunoglobulin-secreting cells in the skin of pigs during Sarcoptes scabiei infestation. Vet. Parasitol. 33 (2), S. 165-175 MULLIS, R. B. und F. A. FALOONA (1987): Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol. 155, S. 335-350 NAGANO, I., F. PEI, Z. WU, J. WU, H. CUI, T. BOONMARS und Y. TAKAHASHI (2004): Molecular Expression of a Cysteine Proteinase of Clonorchis sinensis and Its Application to an Enzyme-Linked Immunosorbent Assay for Immunodiagnosis of Clonorchiasis. Clin. Diagn. Lab. Immunol. 11 (2), S. 411-416 NDE, P. N., T. POGONKA, J. E. BRADLEY, V. P. K. TITANJI und R. LUCIUS (2002): Sensitive and specific serodiagnosis of Onchocerciasis with recombinant hybrid proteins. Am. J. Trop. Med. Hyg. 66 (5), S. 566-571 NIELSEN, H. und A. KROGH (1998): Prediction of signal peptides and signal anchors by a hidden Markov model. Proc. Int. Conf. Intell. Syst. Mol. Biol. 6, S. 122-130 NIEUWLAND, M. G. B., H. W. PLOEGER, A. KLOOSTERMAN und H. K. PARMENTIER (1995): Systematic antibody responses of calves to low molecular weight Cooperia oncophora antigens. Vet. Parasitol. 59 (3-4), S. 231-239 NISHIYAMA, C., T. YASUHARA, T. YUKI und Y. OKUMURA (1997): Recombinant Der f III allergen and its production. Patent: JP 1997040583-A 1 Asahi Breweries LTD, Torii Yakuhin KK, Nikka Uisukii KK NSOSO, S. J., K. P. MOSALA, R. T. NDEBELE und S. S. RAMABU (2000): The prevalence of internal and external parasites in pigs of different ages and sexes in Southeast District, Botswana. Onderstepoort J. Vet. Res. 67 (3), S. 217-220 OLEAGA-PEREZ, A., R. PEREZ-SANCHEZ, A. ASTIGARRAGA und A. ENCINAS-GRANDES (1994 ): Detection of pig farms with Ornithodorus erraticus by pig serology. Elimination of non-specific reactions by carbohydrate epitopes of salivary antigens. Vet. Parasitol. 52 (1-2), S. 97-111 OKANO, M., A. R. SATOSKAR, K. NISHIZAKI, M. ABE und D. A. HARN, jr. (1999): Induction of Th2 Responses and IgE is Largely Due to Carbohydrates Functioning as Adjuvants on Schistosoma mansoni Egg Antigens. J. Immunol. 163 (15), S. 6712-6717 PERMIN, A., L. YELIFARI, P. BLOCH, N. STEENHARD, N. P. HANSEN und P. NANSEN (1999): Parasites in cross-bred pigs in the Upper East Region of Ghana. Vet. Parasitol. 87 (1), S. 63-71 PETERS, N. T., J. A. ROHRBACH, B. A. ZALEWSKI, C. M. BYRKETT und J. C. VAUGHN (2003): RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA 9 (6), S. 698-710 RALSTON, M. J. und D. D. HEATH (1995): A defined antigen for the serodiagnosis of Taenia ovis infections in dogs. J. Parasitol. 81 (3), S. 422-428 RAMACHANDRAN, S., R. W. THOMPSON, A. A. GAM und F. A. NEVA (1998): Recombinant cDNA Clones for Immunodiagnosis of Strongyloidiasis. J. Infect. Dis. 177 (1), S. 196-203 RAWLINGS, N. D. und A. J. BARRETT (1994): Families of serine peptidases. Meth. Enzymol. 244, S. 19-61 REHBEIN, S., M. VISSER, R. WINTER, B. TROMMER, H.-F. MATTHES, A. E. MACIEL und S. E. MARLEY (2003): Productivity effects of bovine mange and control with ivermectin. Vet. Parasitol. 114 (4), S. 267-284 ROBERT-KOCH-INSTITUT (2000): Krätzmilbenbefall (Skabies) - Erkennung, Behandlung und Verhütung. Merkblatt für Ärzte. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 2000, Springer Verlag 43 , S. 550-554 ROOS, T. C., M. ALAM, S. ROOS, H. F. MERK und D. R. BICKERS (2001): Pharmacotherapy of ectoparasitic infections. Drugs 61 (8), S. 1067-1088 RUETER, S. M., T. R. DAWSON und R. B. EMESON (1999): Regulation of alternative splicing by RNA editing. Nature 399 (6731), S. 75-79 SALOTRA, P., G. SREENIVAS, A. A. NASIM, B. V. SUBBA RAJU und V. RAMESH (2002): Evaluation of Enzyme-Linked Immunosorbant Assay for Diagnosis of Post-Kala-Azar Dermal Leishmaniasis with Crude or Recombinant k39 Antigen. Clin. Diagn. Lab. Immunol. 9 (2), S. 370-373 SANDEMAN, R. M., M. ZALUNARDO und C. F. CARGILL (2001): Patentschrift: PCT/AU00/00930, Internationale Publ. Nr.: WO 01/11365 A1 SANGER, F., S. NICKLEN und A. R. COULSON (1977): DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA 74 (12), S. 5463-5467 SCHEIBLHOFER, S., D. CHEN, R. WEISS, F. KHAN, S. MOSTBÖCK, K. FEGEDING, W. W. LEITNER , J. THALHAMER und J. A. LYON (2001): Removal of the circumsporozoite protein (CSP) glycosylphosphatidylinositol signal sequence from a CSP DNA vaccine enhances induction of CSP-specific Th2 type immune responses and improves protection against malaria infection. Eur. J. Immunol. 31 (3), S. 6992-698 SCHNIEDER, T. (1992): Use of recombinant Dictyocaulus viviparus antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of bovine dictyocaulosis. Parasitol. Res. 78 (4), S. 298-302 SCHOFIELD, L. (1991): On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites. Parasitol. Today 7 (5), S. 99-105 SEMENOV, E. P. und W. L. PAK (1999): Diversification of Drosophila Chloride Channel Gene by Multiple Posttranscriptional mRNA Modifications. J. Neurochem. 72 (1), S. 66-72 SKERRATT, L. F., N. J. H. CAMPELL, A. MURELL, S. WALTON, D. KEMP und S. C. BARKER (2002): The mitochondrial 12S gene is a suitable marker of populations of Sarcoptes scabiei from wombats, dogs and humans in Australia. Parasitol. Res. 88 (4), S. 376-379 SMETS, K. und J. VERCRUYSSE (2000): Evaluation of different methods for the diagnosis of scabies in swine. Vet. Parasitol. 90 (1-2), S. 137-145 SOMMER, A., M. NIMITZ, H. S. CONRADT, N. BRATTIG, K. BOETTCHER, P. FISCHER, R. D. WALTER und E. LIEBAU (2001): Structural Analysis and Antibody Response to the Extracellular Glutathione S-Transferases from Onchocerca volvulus. Infect. Immun. 69 (12), S. 7718-7728 STEMMER, B. L., L. G. ARLIAN, M. S. MORGAN, C. M. RAPP und P. F. MOORE (1996): Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions. Vet. Parasitol. 67 (3-4), S. 247-258 TAUSCH, I. (1999): Crotamiton-eine wirksame und sichere Substanz für die Therapie der Skabies, Ergebnisse einer kontrollierten klinischen Prüfung. Z. Hautkr., 3 (74), S. 162-167 TAWILL, S., L. LE GOFF, F. ALI, M. BLAXTER und J. E. ALLEN (2004): Both Free-living and Parasitic Nematodes Induce a Characteristic Th2 Response That Is Dependent on the Presence of Intact Glycans. Infect. Immun. 72 (1), S. 398-407 TELLAM, R. L., C. H. EISEMANN, T. VUOCOLO, R. CASU, J. JARMEY, V. BOWLES und R. PEARSON (2001): Role of oligosaccharides in the immune response of sheep vaccinated with Lucilia cuprina larval glycoprotein, peritrophin-95. Int. J. Parasitol. 31 (8), S. 798-809 VIRGINIO, V. G., A. HERNÁNDEZ, M. B. ROTT, K. M. MONTEIRO, A. F. ZANDONEI, A. NIETO, A. ZAHA und H. B. FERREIRA (2003): A set of recombinant antigens from Echinococcus granulosus with potential for use in the immunodiagnosis of human cystic hydatid disease. Clin. Exp. Immunol. 132 (2), S. 309-315 WALLGREN, P. und S. BORNSTEIN (1997). The spread of porcine sarcoptic mange during the fattening period revealed by development of antibodies to Sarcoptes scabiei. Vet. Parasitol. 73 (3-4), S. 3135-324 WALLIS, A. E. und W. R. MCMASTER (1987): Identification of Leishmania genes encoding proteins containing tandemly repeating peptides. J. Exp. Med. 166 (6), S. 1814-1824 WALTON, S. F., B. J. CURRIE und D. J. KEMP (1997): A DNA fingerprinting system for the ectoparasite Sarcoptes scabiei. Mol. Biochem. Parasitol. 85 (2), S. 187-196 WALTON, S. F., M. R. MYERSCOUGH und B. J. CURRIE (2000): Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis. Trans. R. Soc. Trop. Med. Hyg. 94 (1), S. 92-96 WALTON, S. F., A. DOUGALL, S. PIZZUTTO, D. HOLT, D. TAPLIN, L. G. ARLIAN, M. MORGAN, B. J. CURRIE und D. J. KEMP (2004): Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern Australia. Int. J. Parasitol. 34 (7), S. 839-849 WELLENREUTHER, R., I. SCHUPP, THE GERMAN cDNA CONSORTIUM, A. POUSTKA und S. WIEMANN (2004): SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. BMC Genomics 5 (1): 36,

online Publikation

WENDEL, K. und A. ROMPALO (2002): Scabies and Pediculosis Pubis: An Update of Treatment Regimens and General Review. Clin. Infect. Dis. 35 (2), S. 146-51 WILLIAMSON, K. C., H. FUJIOKA, M. AIKAWA und D. C. KASLOW (1996): Stage-specific processing of PFS230, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol. Biochem. Parasitol. 78 (1-2), S. 161-169 YAMASAKI, H., K. ARAKI, P. K. C. LIM, N. ZASMY, J. W. MAK, R. TAIB und T. AOKI (2000): Development of a Highly Specific Recombinant Toxocara canis Second-Stage Larva Excretory-Secretory Antigen for Immunodiagnosis of Human Toxocariasis. J. Clin. Microbiol. 38 (4), S. 1409-1413 ZAHLER M., A. ESSIG, R. GOTHE und H. RINDER (1999): Molecular analyses suggest monospecifity of the genus Sarcoptes (Acari: Sarcoptidae). Int. J. Parasitol. 29 (5), S. 759-766 ZANG, X., A. K. ATMADJA, P. GRAY, J. E. ALLEN, C. A. GRAY, R. A. LAWRENCE, M. YAZDANBAKHSH und R. M. MAIZELS (2000): The Serpin Secreted by Brugia malayi Microfilariae, BM-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans. J. Immunol. 165 (9), S. 5161-5169.