1Bilanzierung des lymphozytären Energiestoffwechsels von Patienten mit entzündlich – rheumatischen ErkrankungenAntje Kuhnke 213567623#35489101112132142.12.1.12.1.22.1.2.1152.1.2.2162.1.3172.1.3.12.1.3.218192.1.3.320212.1.3.42.1.3.5222.1.3.6232.1.3.72.1.3.8242.1.3.92.1.4252.1.4.1262.1.4.22.1.4.32.227282.32.3.12.3.1.12.3.1.229605#8830565#5522.3.2312.3.2.12.3.2.22.4322.4.1332.4.22.4.2.12.4.2.2342.4.2.3352.4.2.4362.4.2.537382.4.2.62.4.2.7392.5403413.13.1.13.1.1.1617#342423.1.1.2508#38743443.1.245539#38446541#37847541#373483.1.3493.1.3.150561#3363.1.3.251554#338523.1.3.33.1.3.43.1.4533.1.4.154550#3523.1.4.25556527#4063.1.4.35758522#42559531#4173.1.4.4603.2613.2.1502#1823.2.2623.2.2.1605#326633.2.364341#2704654.14.2664.2.167684.2.269707172734.2.374754.2.44.3764.3.177784.3.279542#4028081513#3818283516#37784511#39485864.3.34.3.4874.4888959069192 Abkürzungsverzeichnis95 Literaturverzeichnis96979899100101102103104105106 Eidesstattliche Erklärung 108deInhaltsverzeichnisHilfe Literaturverzeichnis Almawi,W.Y., Assi,J.W., Chudzik,D.M., Lazarovits,A.I. (1999) "Opposing effects of rapamycin and cyclosporin A on activation-induced Ca 2+ release" Eur J Pharmacol 381, 51-56 Arnett,F.C., Edworthy,S.M., Bloch,D.A. et al. (1987) "The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis" Arthritis Rheum 31, 315-24 Banner,K.H., Hoult,J.R.S., Taylor,M.N., Landells,L.J., Page,C.P. (1999) "Possible contribution of prostaglandin E2 to the antiproliferative effect of phosphodiesterase 4 inhibitors in human mononuclear cells" Biochem. Pharmacol. 58, 1487-1495 Berney,S.M., Atkinson,T.P. (1995) "Phosphatidylinositol hydrolysis in freshly isolated human T-lymphocytes" J. Immunol. Methods 186, 71-77 Bianchi,E., Bender,J.R., Blasi,F., Pardi,R. (1997) "Through and beyond the wall - late steps in leukocyte transendothelial migration" Immunology Today 18, 586-591 Bird,H.A., Esselinckx,W., Dixon,A. et al.(1979) "An evaluation of criteria for polymyalgia rheumatica" Annals of the Rheumatic Diseases 38, 434-39 Bonham,M.J., Danielpour,D. (1996) "Improved purification and yields of RNA by RNeasy" Bio Techniques 21, 57-60 Borsook,H., Jiggins,S., Wilson,R.T. (1971) "Two inducers of rapid erythroblast multiplication" in vitro.Nature 230, 328-330 Buc,H.A., Moncion,A., Hamet,M., Perignon (1993) "T-cell antigen receptor-mediated enhancement of the Adenylatzyklase pathway depends on tyrosine protein kinases" Int J Immunopharmac 15, 415-422 Buttgereit,F. (1996) "Habilitationsschrift" Buttgereit,F., Brand,M.D., Burmester,G.R. (1995) "Wirkungen der Glukokortikoide auf das zelluläre Immunsystem" In Nebenniere und Stress pp. 51-59, F.K. Schattauer Verlag,

Stuttgart, New York

Buttgereit,F., Brand,M.D., Müller,M. (1992) "Con A induced changes in energy metabolism of rat thymocytes" Biosci. Rep. 12, 381-386 Buttgereit,F., Brand,M.D., Müller,M. (1993) "Effects of methylprednisolone on the energy metabolism of quiescent and Con A -stimulated thymocytes of the rat" Biosci. Rep. 13, 41-52 Buttgereit,F., Brink,I., Thiele,B., Hiepe,F., Burmester,G.R., Hall,E. (1995) "Effects of methylprednisolone and 21-aminosteroids on mitogen-induced IL-6 and TNF-alpha production in human peripheral blood mononuclear cells" J. Pharm. Exp. Ther. 275, 850-853 Buttgereit,F., Burmester,G.R., Brand,M.D. (2000) "Bioenergetics of immune functions-fundamental and therapeutic aspects" Immunology Today 21, 189-196 Buttgereit,F., Grant,A., Müller,M., Brand,B. (1994) "The effects of methylprednisolone on oxidative phosphorylation in Con A-stimulated thymocytes - top down elasticity analysis and control analysis" Eur. J. Biochem. 223, 513-519 Buttgereit,F., Krauss,S., Brand,M.D. (1997) "Methylprednisolone inhibits uptake of Ca 2+ and Na + ions into concanavalin A-stimulated thymocytes" Biochem. J. 326, 329-332 Buttgereit,F., Müller,M., Rapoport,S.M. (1991) "Quantification of ATP-producing and consuming processes in quiescent pig spleen lymphocytes" Biochem. Int. 42, 59-67 Buttgereit,F., Wehling,M., Burmester,G.R. (1998) "A new hypothesis of modular glucocorticoid actions" Arthritis Rheum 41(5), 761-767 Carson,D.A., Seto,S., Wasson,D.B., Carrera,C.J. (1986) "DNA strand breaks, NAD metabolism and programmed cell death" Exp. Cell. Res. 164, 273-281 Chilson,O.P., Kelly-Chilson,A.E. (1989) "Mitogenic lectins bind to the antigen receptor on human lymphocytes" Eur. J. Immunol. 19, 389-396 Chomczinski,P., Sacchi,N. (1987) "Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction" Anal. Biochem. 162, 156-159 Christoffersen,T., Refsnes,M., Bronstad,G.O., Ostby,E., Huse,J., Haffner,F., Sand,T.E., Hunt,N.H., Sonne,O. (1984) Eur J Biochem 138, 217-226 Conti,M., Nemoz,G., Sette,C., Vicini,E. (1995) "Recent progress in understanding the hormonal regulation of phosphodiesterases" Endocrine Rev. 16, 370-389 Distelhorst,C.W., Dubyak,G. (1998) "Role of Calcium in Glucocorticosteroid-induced Apoptosis of Thymocytes and Lymphoma cells resurrection of old theories by new findings" Blood 91, 731-734 Dukas,K., Sarfati,P., Vaysse,N., Pradayrol,L. (1993) "Quantification of Changes in the Expression of Multiple Genes by Simultaneous Polymerase Chain Reaction" Anal. Biochem. 215, 66-72 Eagle,H. (1955) "Propagation in a fluid medium of a human epidermoid carcinoma, strain KB.(21811)" Poc. Soc. Exp. Biol. Med. 89, 362-364 Edgar,V.A., Sterin-Borda,L., Cremaschi,G.A., Genaro,A.M. (1999) "Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation" Eur J Pharmacol 372, 65-73 Edwardson,J.A., Bennet,G.W. (1974) "Modulation of corticotropin releasing factor release from hypothalamic synaptosomes" Nature 251, 425-427 Ekholm,D., Mulloy,J.C., Gao,G., Degerman,E., Franchini,G., Manganiello,V.C. (1999) "Cyclic nucleotide phosphodiesterase (PDE) 3and 4 in normal, malignant, and HTLV-I transformed human leukcytes" Biochem. Pharmacol. 58, 935-950 El Bawab,S., Macovschi,O., Sette,C., Conti,M., Lagarde,M., Nemoz,G. (1997) "selective stimulation of a cAMP-specific phosphodiesterase (PDE4A5) isoform by phosphadic acid molecular species endogenously formed in rat thymocytes" Eur J Biochem 247, 1151-1157 Elks,M.L., Manganiello,V.C., Vaughan,M. (1984) "Effects of dexamethasone on Adenosine 3`,5´-Monophosphate content and phosphodiesterase activities in 3T3-L1 adipocytes" Endocrin. 115(4), 1350-1356 Erkeller-Yüksel,F., Hulstaart,F., Hannet,I., Isenberg,D., Lydyard,P. (1993) "Lymphocyte subsets in a large cohort of patients with systemic Lupus erythematosus" Lupus 2, 227-231 Eyster,K.M. (1998) "Introduction to signal transduction" Biochem. Pharmacol. 55, 1927-1938 Gallin,E.K. (1991) "Ion channels in leukocytes" Physiol. Rev. 71(3), 775-811 Gassen,H.G., Sachse,G.E., Schulte,A. (1994) "PCR - Grundlagen und Anwendungen der Polymerase Kettenreaktion" Gustav Fischer Verlag Goldbeter,A., Koshland,D.E. (1987) "Energy expenditure in the control of biochemical systems by convalent modification" J. Biol. Chem. 262(10), 4460-71 Gorman,A.L., Thomas,M.V. (1980) "Potassium conductance and internal calcium accumulation in a molluscan neurone" J. Physiol. Lond. 308, 259-285 Goulding,N.J., Guyre,P.M. (1993) "Glucocorticoids, lipocortins and the immune response" Curr. Opin. Immunol. 5, 108-13 Grinstein,S., Dixon,J. (1989) "Ion transport, membrane potential, and cytoplasmatic pH in lymphocytes Changes during activation" Physiol. Rev. 69, 417-481 Grivennikova,V.G., Gavrikova,E.V., Vinogradov,A.D. (1994) "An increase in the energy capacity of submitochondrial particles in the presence of lanthanides" FEBS Letters 349, 403-406 Guppy,M., Greiner,E., Brand,K. (1993) "The role of the crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes" Eur. J. Biochem. 212, 95-99 Guyon,T., Levasseur,P., Truffault,F., Cottin,C., Gaud,C., Berrih-Aknin,S. (1994) "Quantification of steady-state Levels of Messenger RNA in Muscel Biopsy Using the Polymerase Chain Reaction" J. Clin. Invest. 94, 16-24 Hatz,H.J. (1998) "Glucocortikoide - immunologische Grunglagen, Pharmakologie und Therapierichtlinien" Wissenschaftliche Verlagsgesellschaft mbh Stuttgart Hermsdorf,T., Richter,W., Dettmer,D. (1999) "Effects of dexamethasone and glucagon after long term exposure on cyclic AMP Phosphodieserase 4 in cultured rat hepatocytes" Cell. Signal. 11(9), 685-690 Howard,Y. (1997) "Molecular motors structural adaptations to cellular functions" Nature 389, 561-567 Hunder,G.G., Bloch,D.A., Michel,B.A., Stevens,M.B., Arend,W.P., Calabrese,L.H., Edworthy,S.M., Fauci,A.S., Leavitt,R.Y., Lie,J.T. et al. (1990) "The American College of Rheumatology 1990 criteria for the classification of gigant cell arteritis" Arthritis Rheum. 33 (8), 1122-1128 International Study Group for Behcet`s Disease (1990) "Criteria for diagnosis of Behcet`s disease" Lancet 335, 1078-80 Janeway,C.A., Travers,P. (1997) "Immunologie" Spektrum Akademischer Verlag Karlsson,H., De Pierre,J.W., Nässberger,L. (1997) "Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin" in vitro. Biochim. Biophys. Acta 1319, 301-310 Kay,J.E. (1972) "Lymphocyte stimulation by phytohaemagglutinin - role of the early stimulation of potassium uptake" Exp. Cell. Res. 71(1), 245-247 Kiss,T., Osipenko,O.N., (1994) "Toxic effects of heavy metals on ionic channels" Pharmacol Rev 46, 245-267 Köhler,Th., Laßner,D., Rost,A.K., Thamm,B., Pustowoit,B., Remke,H. (1995) "Quantification of mRNA by Polymerase Chain Reaction" Springer Verlag Krauss,S., Buttgereit,F., Brand,M. (1999) "Effects of the mitogen Concanavalin A on pathways of thymocyte energy metabolism" Biochim. Biophys. Acta 1412, 129-138 Kroemer,G., Zamzami,N., Susin,S.A. (1997) "Mitochondrial control of apoptosis" Immunology Today 18(1), 44-51 Lakin-Thomas,P.L., Brand,M.D. (1988) "Stimulation of respiration by mitogens in rat thymocytes is independent of mitochondrial calcium" Biochem. J. 256, 167-173 Lewis,R.S., Cahalan,M.D. (1995) "Potassium and calcium channels in lymphocytes" Annu. Rev. Immunol. 13, 623-653 Lijnen,P., Saavedra,A., Petrov,V. (1997) "In vitro proliferative respons of human peripheral blood mononuclear cells to concanavalin A" Clin. Chim. Acta 264, 91-101 Lohr,M., Keppler,B., (1999) "Innere Medizin – Kompendium für Studium und Klinik" Ullstein Medical Verlagsgesellschaft mbH & Co.,

Wiesbaden

Marcoz,P., Prigent,A.F., Lagarde,M., Nemoz,G. (1993) "Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents" Mol Pharmacol 44, 1027-35 Martens,M.E., Peterson,P.L., Lee,C.P. (1991) "In vitro effects of glucocorticoid on mitochondrial energy metabolism" Biochim. Biophys. Acta 1058, 152-160 Masi,A.T., Medsger,T.A. et al. (1979)"Methods and preliminary results of the scleroderma criteria cooperative study of the American Rheumatism Association" Clinics in the Rheumatic Diseases 5,27-48 Masi,A.T., Medsger,T.A. et al. (1980) "Preliminary criteria for the classification of systemic sclerosis" Arthritis and Rheumatism 23, 581-90 Mc Carty,D.J., O`Duffy,J.D., Pearson,L., Hunter,J.B. (1985) "Remitting Seronegative Symmetrical Synovitis with Pitting Edema - RS3PE Syndrome" Jama 254, 2763-2767 Medsger,T.A., Silman,V.D. et al. (1999) "A Disease Severity Scale for Systemic Sclerosis - Development and Testing" J Rheumatol 26, 2159-67 Meskini,N., Hosni,M., Nemoz,G., Lagarde,M., Prigent,A.F. (1992) "Early increase in Lymphocyte cyclic Nucleotide Phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells" J.Cell. Physiol. 150, 140-148 Miehle,W., Fehr,K., Schattenkirchner,M., Tillmann,K. et al. (2000) "Rheumatologie in Praxis und Klinik" Thieme Verlag, 2.Auflage Migita,K., Eguchi,K., Kawabe,Y. et al. (1997) "Apoptosis induction in human peripheral blood T-Lymphocytes by high.dose steroid therapie" Transplantation 63, 583-587 Moore,F.L., Orchinik,M. (1994) "Membrane receptors for corticosterone - a mechanism for rapid behavioral responses in an amphibian" Horm. Behav. 28, 512-519 Müller,M., Siems,W., Buttgereit,F., Dumdey,R., Rapoport,S.M. (1986) "Quantification of ATP-producing and consuming processes of Ehrlich ascites tumor cells" Eur. J. Biochem. 161, 701-705 Mullis,K.B., Faloona, F. (1987) "Specific synthesis of DNA in vitro via a polymerase chain reaction" Methods in Enzymology 155, 335-350 Oxholm,P. (1992) "Primary Sjögren`s syndrome - clinical and laboratory markers of disease activity" Semin. Arthritis Rheum. 22 (2), 114-26 Parker,C.W., Huber,M.G., Baumann,M.L. (1973) "Alterations in cyclic AMP metabolism in human bronchial asthma. Leukocyte and Lymphocyte responses to steroids" J Clin Invest 52, 1342-8 Petit,P.X., Lecoeur,H., Zorn,E., Dauguet,C., Mignotte,B. (1995) "Early events of dexamethasone-induced thymocyte apoptosis" J. Cell. Biol. 130(1), 157-167 Pschyrembel Klinisches Wörterbuch Rapoport,S.M., Raderecht,H.J. (1977) "Physiologisch-chemisches Praktikum" VEB Verlag Volk und Gesundheit 7.Auflage Rassner,G. (1992) "Dermatologie - Lehrbuch und Atlas" Urban & Schwarzenberg Verlag Rolfe,D.F.S., Brand,M.D. (1997) "The physiological significance of mitochondrial protonen leak in animal cells and tissues" Biosci. Rep. 17, 9-16 Saiki,R.K., Scharf,S., Faloona,F., Mullis,K.B., Horn,G.T., Erlich,H.A., Arnheim,N. (1985) "Enzymatic amplifikation of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia" Science 230, 1350-1354 Schmid,D. (2000) "Dissertation-Bilanzierung des zellulären Energiestoffwechsels humaner Lymphozyten und die therapeutische Beeinflussung durch Glukokortikoide" vorgelegt der Medizinischen Fakultät der Humboldt-Universität zu Berlin Segal,J. (1986) "Lanthanum increases the rat thymocyte cytoplasmatic free calcium concentration by enhancing calcium influx" Biochim. Biophys. Acta 886, 267-271 Segerer,S., Dietz-Laukemann,P., Schattenkirchner,M. (1999) "Das RS3PE-Syndrom" Z Rheumatol 58, 35-38 Seligmann,B. (1990) "Monovalent ion transport and membrane potential changes during leukocyte activation lymphocytes" in Kleinzeller,A., Grinstein,S., Rothstein,O. Current Topics in Membranes and Transport. Mechanism of Leukocyte Activation. Academic Press.

New York

. 35, 103-125 Seth,S.B., Chaganti,K., Bastepe,M., Ajuria,J., Brennan,K., Biradavolu,R., Colman,R.W. (1997) "Cyclic AMP phosphodiesterases in human lymphocytes" Br. J. Haematol. 99, 784-789 Seto,S., Carrera,C.J., Wasson,D.B., Carson,D.A. (1986) "Inhibition of DNA by deoxyadenosine in resting human lymphocytes" J. Immunol., 136 (8), 2839-43 Siems,W., Dubiel,W., Dumdey,R., Müller,M., Rapoport,S.M. (1984) "Accounting for ATP-consuming processes in rabbit reticulocytes" Eur. J. Biochem. 139, 101-107 Silman,A.J., Symmons,D.P.M. (1995) "Classification and Assessment of Rheumatic Diseases" Bailliere`s Clinical Rheumatology Skalhegg,B.S., Rasmussen,A.M., Tasken,K., Hansson,V. (1994) "Cyclic AMP sensitive signalling by the CD28 Marker requires concomitant stimulation by the T-cell antigen receptor complex" Scand J Immunol 40, 201-208 St Clair,E.W., Mc Callum, R.M. (1999) "Cogan`s syndrome" Current Opinion in Rheumatology 11, 47-52 Tamir,A., Granot,Y., Isakov,N. (1996) "Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-jun N-terminal kinase" Immunology 157, 1514-1522 Tan,E.M., Cohen,A.S., Fries,J.F. et al.(1982) "The revised criteria for the classification of systemic lupue erythematosus" Arthritis Rheum. 25, 1271-1277 Thoresen,G.H., Gjone,I.H., Gladhaug,I.P., Refsnes,M., Ostby,E., Christoffersen,T. (1989) "Studies of glucocorticoid enhancement of the capacity of hepatocytes to accumulate cyclic AMP" Pharmacol Toxicol 65, 175-180 Trueba,M., Ibarolla,I., Ogiza,K., Marino,A., Macarulla,J.M. (1991) "Specific binding sites for corticosterone in isolated cells and plasma membranes from rat liver" J. Membr. Biol. 120, 115-124 Van Noort,J.M., Amor,S. (1998) "Cell biology of autoimmune diseases" Int. Rev. Cytol. 178, 127-206 Venables,P.J.W. (1996) "Overlap syndromes" Brit. J. Rheumatol . 35, 305-308 Vitali et al.(1992) "European consensus lupus activity measurement" Clinical and Experimental Rheumatology 10, 541-547 Vitali,C., Bombardieri,S., Moutsopoulos,H.M., Balestrieri,G., Bencivelli,W., Bernstein,R.M., Bjerrum,K.B., Braga,S., Coll,J., de-Vita,S. et al. (1993) "Preliminary criteria for the classification of Sjogren`s syndrome. Results of a prospective concerted action supported by the European Community" Arthritis Rheum. 36 (3), 340-47 Voet,D., Voet,J. (1992) "Biochemie" VHC Wehling,M. (1997) "Specific, nongenomic actions of steroid hormones" Annu. Rev. Physiol. 59, 365-93 Wertenauer,J. (2000) "Dissertation - Untersuchungen zur Wirkung von Methylprednisolon und Anti-cd4-Antikörper auf die Signaltransduktion in PBMC" Veröffentlichung voraussichtlich im Jahr 2000 durch die Universitätsklinik Charite, Humboldt Universität Berlin Yakura,H. (1998) "Phosphatases and kinases in lymphocyte signaling" Immunology Today 19(5), 198-201 Yingling,J.D., Fuller,L.Z., Jackson,B.A. (1994) "Modulation of cyclic AMP metabolism by glucocorticoids in PC 18 cells" J. Neurochem. 63, 1271-1276 Yocum,D.E. (1999) "T-cells Pathogenetic cells and therapeutic targets in Rheumatoid Arthritis" Semin. Arthritis Rheum. 29, 27-35 Zempleni,J., Mock,D.M. (1999) "Mitogen - induced proliferation increases biotin uptake into human peripheral blood mononuclear cells" Am. J. Physiol. 276 (Cell Physiol. 45), C1079-C1084