Was ist Leukozytoklasie?Eine histologische und elektronenmikroskopische Untersuchung an kutaner leukozytoklastischer VaskulitisKristin Ladell 341101.11.211594#5521.3121314604#4841.41522.12.2162.32.417182.4.1192.52.5.1202.5.22122604#4832.6232.7242.82.92533.13.1.1263.1.22728293.1.330313.23.2.13.2.1.13.2.1.23.2.1.2.1323.2.1.33.2.1.3.13.2.1.4333.2.2343.2.2.13.2.2.1.13.2.2.2353.2.2.2.166#1463637383.2.2.2.23.2.2.2.3393.2.2.3403.2.33.2.3.1413.2.3.24424.14.1.143444.1.2454.2464748495051524.3534.4544.4.1555657496#338495#33558463#400456#35659420#297420#41060483#371476#39061323#408323#37962331#412329#41563331#432331#41764328#43365329#451327#33666329#457329#39667313#380311#42268325#429325#4135695.1705.271725.3735.4745.4.1755.4.2765.4.3775.578795.6805.78168283 Abkürzungsverzeichnis89Danksagung84LebenslaufEidestattliche Erklärung Literatur858687888990919293949596979899100deInhaltsverzeichnisHilfe Literatur 1 Abend M., Schmelz H.U., Kraft K., Rhein A.P., van Beuningen D., Sparwasser C. Intercomparison of Apoptosis morphology with active DNA cleavage on single cells in vitro and on testis tumors. J. Pathol. 1998 185 419-26 2 Alderson M.R., Tough T.W., Davis-Smith T., Braddy S., Falk B., Schooley K.A., Goodwin R.G., Smith C.A., Ramsdell F., Lynch D.H. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 1995 181 71-77 3 Almendral J.M., Huebsch D., Blundell P.A., Macdonald-Bravo H., Bravo R. . Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. Proc. Natl. Acad. Sci. 1987 84 1575-9 4 Anderson C.L., Shen L., Eicher D.M., Wewers M.D., Gill J.K. Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes. J. Exp. Med. 1990 171 1333-45 5 Argenbright L.W., Barton R.W. Interaction of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. J. Clin. Invest. 1992 89 259-72 6 Arthus M. Injections répétées de sérum de cheval chez le lapin. C R Seances Soc Biol Filiales 1903 55 817 7 Banno S., Tamada Y., Matsumoto Y., Ohashi M. Apoptotic cell death of neutrophils in development of skin lesions of patients with Anaphylactoid purpura. J. Dermatol. 1997 24 94-99 8 Barduagni S., Frezzolini A., Ferrant G.i, Papi M., De Pita O. In situ labelling of fragmented DNA in cutaneous necrotizing vasculitis. J. Dermatol. Science 1998 17 160-4 9 Bessis M.C. Death of a Cell, 16-mm Film.

New York

Swift Motion Picture Laboratories. 1958 10 Brach M.A., de Vos S., Gruss H.-J., Herrmann F. Prolongation of Survival of Human Polymorphonuclear Neutrophils by Granulocyte-Macrophage Colony-Stimulating Factor Is Caused By Inhibition of Programmed Cell Death. Blood 1992 80 2920-4 11 Braun-Falco O., Plewig G., Wolff H.H. Erkrankungen der Blutgefäße; Hämorrhagische Diathesen; Vasculitis allergica (Gougerot 1932, Ruiter-Brandsma 1948) (Schönlein 1832, Henoch 1868) Dermatologie und Venerologie 4.

Heidelberg

Springer Verlag Berlin 1996 794-886 12 Braverman I.M., Yen A. Demonstration of immune complexes in spontaneous and Histamin-induced lesions and in normal skin of patients with leukocytoclastic angiitis. J. Invest. Dermatol. 1975 64 105-112 13 Bravo R., Frank R., Blundell P.A., Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 1987 326 515-7 14 Callen J.P., Kallenberg C.G.M. The vasculitides: relationship of cutaneous vasculitis to systemic disease. Kater L., Baart de la Faille H. Multi-Systemic Auto-Immune Diseases: an integrated approach.

Amsterdam

Elsevier 1995 267-97 15 Campanile G., Lotti T. Clinical aspects of cutaneous necrotizing vasculitis. Int. Angiol. 1995 14 151-61 16 Claudy A.L. Diagnosis of cutaneous vasculitis. Int. Angiol. 1995 14 183-7 17 Claudy A. Review article: Pathogenesis of leukocytoclastic vasculitis. Eur. J. Dermatol. 1998 8 75-79 18 Cochrane C.G., Weigle W.O., Dixon F.J. The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis. J. Exp. Med. 1959 110 481-94 19 Cochrane C.G. Studies on localization of circulating antigen antibody complexes and other macromolecules in vessels. I. Structural studies. J. Exp. Med. 1963 118 489-502 20 Cochrane C.G. Studies on localization of circulating antigen antibody complexes and other macromolecules in vessels. II. Pathogenetic and pharmacodynamic studies. J. Exp. Med. 1963 118 503-13 21 Cochrane C.G. Mediators of the Arthus and related reactions. Prog. Allergy 1967 11 1-35 22 Cochrane C.G., Muller-Eberhard H.J., Aikin B.S. Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J. Immunol. 1970 105 55-69 23 Cochrane C.G. Mechanisms involved in the deposition of immune complexes in tissues. J. Exp. Med. 1971 134 Suppl. 75s-89s 24 Cohen G.M., Sun X.M., Snowden R.T., Dinsdale D., Skilleter D.N. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 1992 286 331-4 25 Collins R.J., Harmon B.V., Gobe G.C., Kerr J.F. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int. J. Radiat. Biol. 1992 61 451-3 26 Colotta F., Re F., Polentarutti N., Sozzani S., Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 1992 80 2012-20 27 Cordell J.L., Falini B., Erber W.N., et al. Immunoenzymatic Labeling of Monoclonal antibodies Using Immune Complexes of Alkaline Phosphatase and Monoclonal Anti-alkaline Phosphatase (APAAP Complexes). J. Histochem. Cytochem. 1984 32 219-29 28 Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. J. Immunol. 1995 154 4719-25 29 Cream J.J., Bryceson A.D.M., Ryder G. Disappearance of immunglobulin and complement from the Arthus reation and its relevance to the studies of vasculitis in man. Br. J. Dermatol. 1971 84 106-9 30 Csernok E., Ernst M., Schmitt W., Bainton D.F., Gross W.L. Activated neutrophils express PR3 on their plasma membrane in vitro and in vivo. Clin. Exp. Immunol. 1994 95 244-50 31 Daeron M. Fc receptor biology. Annu. Rev. Immunol. 1997 15 203 32 Debatin K.M. Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohematopoetic cells. Cell Death and Diff. 1996 3 185-9 33 de la Salle H., Galon J., Bausinger H., Spehner D., Bohbot A., Cohen J., Cazenave J.P., Fridman W.H., Sautes C., Hanau D. Soluble CD16/Fc gamma RIII induces maturation of dendritic cells and production of several cytokines including IL-12. Adv. Exp. Med. Biol. 1997 417 345-52 34 Delia D., Aiello A., Soligo D., Fontanella E., Melani C., Pezzella F., Pierotti M.A., Della Porta G. Bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood 1992 79 1291-8 35 Dianzani U., Bragardo M., DiFranco D., Alliaudi C., Scagni P., Buonfiglio D., Redoglia V., Bonissoni S., Correra A., Dianzani I., Ramenghi U. Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation. Blood 1997 89 2871-9 36 Dibbert B., Weber M., Nikolaizik W.H., Vogt P., Schöni M.H., Blaser K., Simon H.-U. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation. PNAS 1999 96 13331-35 37 DiGiuseppe J.A., LeBeau P., Augenbraun J., Borowitz M.J. Multiparameter flow-cytometric analysis of bcl-2 and Fas expression in normal and neoplastic hematopoiesis. Am.J.Clin.Pathol. 1996 106 345-51 38 Dockrell D.H., Badley A.D., Algeciras-Schimnich A., et al. Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number. AIDS Res. Hum. Retroviruses 1999 15 1509-18 39 Dransfield I.,Buckle A.-M.,Savill J.S., McDowall A., Haslett C., Hogg N. Neutrophil apoptosis is associated with a reduction in expression of CD 16 (Fc g RIII) expression. J. Immunol. 1994 153 1254-63 40 Druilhe A, Cai Z, Haile S, Chouaib S, Pretolani M. Fas-mediated apoptosis in cultured human eosinophils. Blood 1996 87 2822-30 41 Ellis R.E., Yuan J., Horvitz H.R. Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 1991 7 663-82 42 Enari M., Hase A., Nagata S. Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 1995 14 5201-8 43 Fadok V.A., Savill J.S., Haslett C., Bratton D.L., Doherty D.E., Campbell P.A., Henson P.M. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 1992 149 4029-35 44 Fadok V.A., Bratton D.L., Rose D.M., Pearson A., Ezekewitz R.A.B., Henson P.M. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000 405 85-90 45 Falk R.J., Terrell R.S., Charles L.A., Jennette J.C. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. 1990 87 4115-9 46 Farace F., Mitjavila M.T., Betaieb A., Dokhelar M.C., Wiels J., Finale Y., Kieffer N., Breton-Gorius J., Vainchenker W., Tursz T. New hematopoietic differentiation antigens detected by anti-K562 monoclonal antibodies. Cancer Res. 1988 48 5759-65 47 Fauci A.S., Haynes B.F., Katz P. The spectrum of vasculitis. Clinical, pathologic, immunologic, and therapeutic considerations. Ann. Intern. Med. 1978 89 660-76 48 Fecho K., Cohen P.L. Fas ligand (gld)- and Fas (lpr)-deficient mice do not show alterations in the extravasation or apoptosis of inflammatory neutrophils. J. Leukoc. Biol. 1998 64 373-83 49 Findley H.W., Gu L., Yeager A.M., Zhou M. Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 1997 89 2986-93 50 Fleit H.B., Kuhnle M. Biochemical characterization of an Fc receptor purified from human neutrophils. J. Immunol. 1988 140 3120-5 51 Frey T. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems. Cytometry 1997 28 253-63 52 Fritsch Dermatologie und Venerologie, Lehrbuch und Atlas

Heidelberg

Springer Verlag Berlin 1998 493-505 53 Gamberale R., Giordano M., Trevani A.S., Andonegui G., Geffner J.R. Modulation of Human Neutrophils Apoptosis by Immune Complexes. J. Immunol. 1998 161 3666-74 54 Gammon R. Leucocytoclastic vasculitis. Clin. Rheum. Dis. 1982 8 397-413 55 Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 1992 119 493-501 56 Geffner J.R., Giordano M., Serebrinsky G., Isturiz M.A. Different activation pathways involved in antibody-dependent and immune-complexes-triggered cytotoxicity mediated by neutrophils. Clin. Exp. Immunol. 1988 74 471-6 57 Goeken J.A. Antineutrophil cytoplasmic and anti-endothelial cell antibodies: mechanisms for vasculitis. Curr. Opin. Dermatol. 1995 1 75 58 Gräper L. Eine neue Anschauung über physiologische Zellausschaltung. Arch. Zellforsch. 1914 12 373-94 59 Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 1995 21 1465-146 60 Griffith T.S., Yu X., Herndon J.M., Green D.R., Ferguson T.A. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 1996 5 7-16 61 Grigg J.M., Savill J.S., Sarraf C., Haslett C., Silverman M. Neutrophil apoptosis and clearance from neonatal lungs. Lancet 1991 338 720-22 62 Gross W.L., Csernok E. Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. Curr. Op. Rheumatol. 1995 7 11-19 63 Grunwald M.H., Avinoach I., Amichai B., Halevy S. Leukocytoclastic vasculitis: correlation between different histologic stages and direct immunofluorescence. Int. J. Dermatol. 1975 64 105-112 64 Grunwald M.H., Shriker O., Halevy S., Alkan M., Levy R. Impaired neutrophil functions in patients with leukocytoklastic vasculitis. Int. J. Dermatol. 1997 36 509-513 65 Hamasaki A., Sendo F., Nakayama K., Ishida N., Negishi I., Nakayama Ki., Hatakeyama S. Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J. Exp. Med. 1998 188 1985-92 66 Hanada M., Aime-Sempe C., Sato T., Reed J.C. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem. 1995 270 11962-9 67 Harper L., Savage C.O.S. Review Article: Pathogenesis of ANCA-associated systemic vasculitis. J. Pathol. 2000 190 349-59 68 Haslett C., Savill J.S., Whyte M.K., Stern M., Dransfield I., Meagher L.C. Granulocyte apoptosis and the control of inflammation. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1994 345 327-33 69 Haynes B.F. Vasculitis. Pathogenic mechanisms of vessel damage. Gallin J.I., Goldstein I.M., Snyderman R. Inflammation: Basic Principles and Clinical Correlates. 2.

New York

Raven Press 1992 921-41 70 Hazen P.G., Michel B. Management of necrotizing vasculitis with cholchicine. Improvement in patients with cutaneous lesions and Behcet's syndrome. Arch. Dermatol. 1979 115 1303-6 71 Hockenbery D.M., Zutter M., Hickey W., Nahm M., Korsmeyer S.J. bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. 1991 88 6961-5 72 Homburg C.H., de Haas M., von dem Borne A.E., Verhoeven A.J., Reutelingsperger C.P., Roos D. Human neutrophils lose their surface Fcgamma RIII and acquire Annexin V binding sites during apoptosis in vitro. Blood 1995 85 532-40 73 Hruban R.H., Kuhajda F.P., Mann R.B. Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaryocytic leukemia. Am. J. Clin. Pathol. 1987 88 578-88 74 Hundt M., Schmidt R.E. The glycosylphosphatidylinositol-linked Fc gamma receptor III represents the dominant receptor structure for immune complex activation of neutrophils. Eur. J. Immunol. 1992 22 811-6 75 Hurley J.V. Termination of Acute Inflammation. (In: Acute Inflammation)

London

Churchill Livingstone 1983 109-17 76 Ierino F.L., Powell M.S., McKenzie I.F.C, Hogarth P.M. Recombinant soluble human Fcgamma RII: production, characterization, and inhibition of the Arthus reaction. J. Exp. Med. 1993 178 1617-28 77 Iida K., Mornaghi R., Nussenzweig V. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. J. Exp. Med. 1982 155 1427-38 78 Indik Z.K., Park J.G., Hunter S., Mantaring M., Schreiber A.D. Molecular dissection of Fc gamma receptor-mediated phagocytosis. Immunol. Lett. 1995 44 133-8 79 Itho N., Yonehara S., Ishii A., Yonehara M., Mizushima S., Sameshima M., Hase A., Seto Y., Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Eur. J. Immunol. 1991 24 440-44 80 Itho N., Tsujimoto Y., Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immuol. 1993 151 621-27 81 Iwai K., Miyawaki T., Takizawa T., Konno A., Ohta K., Yachie A., Seki H., Taniguchi N. Differential Expression of bcl-2 and Susceptibility to Anti-Fas-Mediated Cell Death in Peripheral Blood Lymphocytes, Monocytes and Neutrophils. Blood 1994 84 1201-8 82 Jaattela M., Benedict M., Tewari M., Shayman J.A., Dixit V.M. Bcl-x and Bcl-2 inhibit TNF-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 1995 10 2297-305 83 Jenette J.C., Falk R.J., Anddrassy K., Bacon P.A., Churg J., Gross W.L., Hagen E.C., Hoffman G.S., Hunder G.G., Kallenberg C.G.M., McCluskey R.T., Sinico R.A., Rees A.J., van Es LA, Waldherr R., Wiik A. Nomenclature of systemic vasculitides. Arthritis Rheum. 1994 37 187-92 84 Jimenez M.F., Watson R.W., Parodo J., Evans D., Foster D., Steinberg M., Rotstein O.D., Marshall J.C. Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. Arch. Surg. 1997 132 1263-70 85 Jones J., Morgan B.P. Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation. Immunology 1995 86 651-60 86 Jorizzo J.L., Solomon A.R., Zanolli M.D.,Leshin B. Neutrophilic vascular reactions. J. Am. Acad. Dermatol. 1988 19 983-1005 87 Jorizzo J.L. Classifacation of vasculitis. J. Invest. Dermatol. 1993 100 106-10 88 Ju S., Panka D.J., Cui H., Ettinger R., El-Khatib M., Sherr D.H., Stranger B.Z., Marshak-Rothstein A. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 1995 373 444-8 89 Kagi D., Vignaux F., Ledermann B., Burki K., Depraetere V., Nagata S., Hengartner H., Golstein P. Fas and perforin pathways as major mechanisms of T-cell mediated cytotoxicity. Science 1994 265 528-30 90 Kallenberg C.G.M, Brouwer E., Weening J.J., Cohen Tervaert J.W. Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiological potential. Kidney Int. 1994 46 1-15 91 Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ord T., Bredesen D.E. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993 262 1274-7 92 Karasek M.A. Microvascular endothelial cell culture. J. Invest. Dermatol. 1989 93 33-38 93 Katz S.I. Dapsone, in Dermatology, Chap. 233 Fitzpatrick T.B., Eisen A.Z., Wolf K., Freedberg I.M., Austen K.F. General Medicine 2 4.

New York

McGraw-Hill, Inc. 1993 94 Kawana S. The membrane attack complex of complement alters the membrane integrity of cultured endothelial cells: a possible pathophysioloy for immune complex vasculitis. Acta. Dermatol. Venereol. 1996 76 13-16 95 Kerr J.F.R. Shrinkage necrosis: a distinct mode of cellular death. J. Pathol. 1971 105 13-20 96 Kerr J.F.R., Wyllie A.H, Currie A.R. Apoptosis a basics biological phenmenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972 26 239-57 97 Kerr J.F.R, Harmon B.V. Tomei L.D., Cope F.O. Apoptosis I: The molecular basis of cell death. Cold Spring Harbor Laboratory Press 1991 5-29 98 Klebs E. Die Allgemeine Pathologie. Zweiter Theil. Störungen des Baues und der Zusammensetzung.

Jena

1889 Gustav Fischer Verlag 99 Knepper Nicolai B., Savill J., Brown S.B. Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases. J. Biol. Chem. 1998 273 30530-6 100 Koenderman L., Hermans S.W., Capel P.J., van-de-Winkel J.G. Granulocyte-macrophage colony-stimulating factor induces sequential activation and deactivation of binding via a low-affinity IgG Fc receptor, hFc gamma RII, on human eosinophils. Blood 1993 81 2413-9 101 Kolde G., Henseleit U., Rosenbach T. Programmed Cell Death in Cutaneous Immunopathology. Bos J.D. The Skin Immune System.

New York

CRC Press,

Boca Raton-New York

1997 327-38 102 Korsmeyer S.J., Shutter J.R., Veis D.J., Merry D.E., Oltvai Z.N. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer. Biol. 1993 4 327-32 103 Krajewski K., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the Bcl-2 oncoprotein : residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 1993 53 4701-14 104 Krajewski K., Bodrug S., Krajewska M., Shabaik A., Gasgoyne N., Berean K., Reed J.C. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am. J. Pathol. 1995 146 1309-19 105 Kurki P., Ogata K., Tan E.M. Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry. J. Immunol. Methods 1988 109 49-59 106 Lagasse E., Weissman I.L. Bcl-2 Inhibits Apoptosis of Neutrophils but Not Their Engulfment by Macrophages. J. Exp. Med. 1994 179 1047-52 107 Le Deist F., Emile J.F., Rieux-Laucat F., Benkerrou M., Roberts I., Brousse N., Fischer A. Clinical, immunological, and pathological consequences of Fas-deficient conditions. Lancet 1996 348 719-23 108 Lee A., Whyte M.K., Haslett C. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J. Leukoc. Biol. 1993 54 283-8 109 Leibovich S.J., Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am. J. Pathol. 1975 78 71-100 110 Leverkus M., Yaar M., Gilchrest B.A. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp. Cell Res. 1997 232 255-62 111 Levine A.J., Momand J., Finlvay C.A. The p53 tumor suppressor gene. Nature 1991 351 453-6 112 Liao G., Simon S.R. Temporal down-regulation of Fc gamma RIII expression and Fc gamma receptor-mediated phagocytosis in human monocyte-derived macrophages induced by TNF-alpha and IL-1 beta. J. Leukoc. Biol. 1994 55 702-10 113 Liles W.C., Klebanoff S.J. Regulation of Apoptosis in Neutrophils-Fas track to death? J. Immunol. 1995 155 3289-91 114 Liles C., Kiener P.A., Ledbetter J.A., Aruffo A., Klebanoff S. J. Differential Expression of Fas (CD95) and Fas Ligand on Normal Human Phagocytes:Implications for the Regulation of Apoptosis in Neutrophils. J. Exp. Med. 1996 184 429-40 115 Listman J.A., Wang Y., Castro J.E., Rimm I.J., Finn P.W., Perkins D.L. Detection of rare apoptotic T cells in vivo. Cytometry 1998 33 340-7 116 Lockshin R.A., Williams C.M. Programmed cell death. II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths. J. Insect. Physiol. 1964 10 643-49 117 Lotti T. The management of systemic compilications of vasculitis. Panconesi E. Dermatology in Europe.

Oxford

Blackwell Science Publications 1991 330-2 118 Lotti T., Comacchi C., Ghersetich I. Cutaneous necrotizing vasculitis. Int. J. Dermatol. 1996 35 457-74 119 Lotti T., Ghersetich I., Comacchi C., Jorizzo J.L. Cutaneous small-vessel vasculitis. J. Am. Acad. Dermatol. 1998 39 667-87 120 Lowin B., Hahne M., Mattmann C., Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994 370 650-52 121 Lynch P.J. Vascular reactions. Schachner L.A., Hansen R.C. Pediatric dermatology.

New York

Churchill Livingstone 1988 959-1014 122 Mackel S.E., Jordon R.E. Leukocytoklastic vasculitis: a cutaneous expression of immune complex disease. Arch. Dermatol. 1982 118 296-301 123 Majno G., Joris I. Review: Apoptosis, Oncosis, and Necrosis. An Overview of Cell Death. Am. J. Pathol. 1995 146 3-15 124 Malech H.D., Gallin J.I. Neutrophils in human diseases. New Eng. J. Med. 1988 317 687-92 125 Martin D.A., Combadiere B., Hornung F., Jiang D., McFarland H., Siegel R., Trageser C., Wang J., Zheng L., Lenardo M.J. Molecular genetic studies in lymphocyte apoptosis and human autoimmunity. Novartis. Found. Symp. 1998 215 73-91 126 Marzo I., Brenner C., Zamzami N., Susin S.A., Beutner G., Brdiczka D., Remy R., Xie-Z.H., Reed J.C., Kroemer G. The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J. Exp. Med. 1998 187 1261-71 127 Mathews M.B., Bernstein R.M., Franza B.R. Jr., Garrels J.I. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984 309 374-6 128 Matsumoto K., Schleimer R.P., Saito H., Iikura Y., Bocher B.S. Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro. Blood 1995 86 1437-43 129 Meagher L.C., Savill J.S., Baker A., Haslett C. Phagocytosis of apoptotic neutrophils does not induce macrophage release of Thromboxane B2. J. Leuk. Biol. 1992 52 269-73 130 Meikrantz W., Gisselbrecht S., Tam S.W., Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc. Natl. Acad. Sci. 1994 91 3754-8 131 Memon S.D., Guy G.R., Tan Y.H. Involvement of a putative protein-tyrosine phosphatase and I kappa B-alpha serine phosphorylation in nuclear factor kappa B activation by tumor necrosis factor. J. Biol. Chem. 1995 270 18881-7 132 Meszaros A.J., Reichner J.S., Albina J.E. Macrophage phagocytosis of wound neutrophils. J. Leukoc. Biol. 1999 65 35-42 133 Micklem K., Rigney E., Cordell J., Simmons D., Stross P., Turley H., Seed B., Mason D. A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies. Br. J. Haematol. 1989 73 6-11 134 Middelhoven P.J., Van-Buul J.D., Kleijer M., Roos D., Hordijk P.L. Actin polymerization induces shedding of FcgammaRIIIb (CD16) from human neutrophils. Biochem. Biophys. Res. Commun. 1999 255 568-74 135 Miwa K., Asano M., Horai R., Iwakura Y., Nagata S., Suda T. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat. Med. 1998 4 1287-92 136 Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995 80 293-9 137 Molica S., Mannella A., Dattilo A., Levato D., Iuliano F., Peta A., Consarino C., Magro S. Differential expression of BCL-2 oncoprotein and Fas antigen on normal peripheral blood and leukemic bone marrow cells. A flow cytometric analysis. Haematologica 1996 81 302-9 138 Monaghan P., Robertson D., Amos T.A., Amos S., Dyer M.J., Mason D.Y., Greaves M.F. Ultrastructural localization of Bcl-2 protein. J. Histochem. Cytochem. 1992 40 1819-25 139 Moser R., Etter H., Oligati L., Fehr J. Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fcgamma RII (CD32) and Fcgamma RIII (CD16). J. Lab. Clin. Med. 1995 126 588-96 140 Moulding D.A., Quayle J.A., Hart C.A., Edwards S.W. Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood 1998 92 2495-502 141 Moulding D.A., Hart C.A., Edwards S.W. Regulation of neutrophil FcgammaRIIIb (CD16) surface expression following delayed apoptosis in response to GM-CSF and sodium butyrate. J. Leukoc. Biol. 1999 65 875-82 142 Muller Kubold A., Kallenberg C., Cohen Tervaert J. Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis. Br. J. Rheum. 1998 37 901-7 143 Nagata S. Fas and Fas ligand: a death factor and its receptor. Adv. Immunol. 1994 57 129-144 144 Nagata S., Golstein P. The Fas death factor. Science 1995 267 1449-56 145 Negoescu A., Lorimier P., Labat-Moleur F., Azoti L., Robert C., Guillermet C., Brambilla C., Brambilla E. TUNEL: Improvement and Evaluation of the Method for In Situ Apoptotic Cell Identification. Biochemica Information 1997 101 19-23 146 Newman S.L., Henson J.E., Henson P.M. Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages. J. Exp. Med. 1982 156 430-42 147 Norman K.E., Moore K.I., McEver R.P., Ley K. Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1. Blood 1995 86 4417-21 148 Ogata K., Kurki P., Celis J.E., Nakamura R.M., Tan E.M. Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication. Exp. Cell. Res. 1987 168 475-86 149 Ohta K., Iwai K., Kasahara Y., Taniguchi N., Krajewski S., Reed J.C., Miyawaki T. Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. Int. Immunol. 1995 7 1817-25 150 Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993 74 609-19 151 Osborne B.A., Schwartz L.M. Essential genes that regulate apoptosis. Trends Cell Biol. 1994 4 394 152 Oshimi Y., Oda S., Honda Y., Nagata S., Miyazaki S. Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells. J. Immunol. 1996 157 2909-15 153 Ottonello-L; Tortolina-G; Amelotti-M; Dallegri-F. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes. J. Immunol. 1999 162 3601-6 154 Payne C.M., Glasser L., Tischler M.E., Wyckoff D., Cromey D., Fiederlein R., Bohnert O. Programmed cell death of the normal human neutrophil: an in vitro model of senescence. Microsc. Res. Tech. 1994 28 327-44 155 Pender M.P. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance. Immunol. Cell. Biol. 1999 77 216-23 156 Petit P.X., Susin S.A., Zamzami N., Mignotte B., Kroemer G. Mitochondria and programmed cell death: back to the future. FEBS Lett. 1996 396 7-13 157 Pinching A.J., Rees A.J., Pussell B.A., Lockwood C.M., Mitchison R.S., Peters D.K. Relapses in Wegener's granulomatosis: the role of infection. Br. Med. J. 1980 281 836-8 158 Pulford K.A.F, Rigney E.M., Micklem K.J. et al. KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J. Clin. Pathol. 1989 42 414-21 159 Pulford K.A.F, Sipos A., Cordell J.L., Stross W.P., Mason D.Y. Distribution of the CD68 macrophage/myeloid associated antigen. Int. Immunol. 1990 2 973-80 160 Quinlan K.L., Olerud J., Armstrong C.A., Caughman S.W., Ansel J.C. Neuropeptides upregulate expression of adhesion molecules on human keratinocytes and dermal microvascular endothelial cells. (abstract) J. Invest. Dermatol. 1997 108 551 161 Raff M.C. Review-Artikel: Social controls on cell survival and cell death. Nature 1992 356 397-400 162 Rainger G., Fischer A., Nash G. Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobalise rolling neutrophils. Am. J. Physiol. 1997 272 H114-H122 163 Ralston D., Marsh C., Lowe M., Wewers M. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. J. Clin. Invest. 1997 100 1416-24 164 Ravetch J.V. Fc receptors: rubor redux. Cell 1994 78 553-60 165 Ravetch J.V. Fc receptors. Curr. Opin. Immunol. 1997 9 121-5 166 Reed J.C., Jurgensmeier J.M., Matsuyama S. Bcl-2 family proteins and mitochondria. Biochim. Biophys. Acta. 1998 1366 127-37 167 Resnick A.H, Esterly N.B. Vasculitis in children. Int. J. Dermatol. 1985 24 139-46 168 Reumaux D., Vossebeld P.J.M, Roos D., Verhoeven A.J. Effect of tumor necrosis factor-induced integrin activation on Fcgamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood 1995 86 3189-95 169 Roitt I., Brostoff J., Male D. Chapter 24, Hypersensitivity-Type III Immunology 4.

London

Mosby 1996 24.1-24.12 170 Romeis Mikroskopische Technik 17.

Müchen-Wien-Baltimore

Urban und Schwarzenberg 1989 235-36 171 Russell S.W., Rosenau W., Lee J.C. Cytolysis induced by human lymphotoxin. Cinemicrographic and electron microscopic observations. Am. J. Pathol. 1972 69 103-18 172 Ryan T.J. Cutaneous vasculitis. Rook A., Wilkinson D.S., Ebling F.J.G. Textbook of Dermatology.

Oxford

Blackwell Scientific Publications 1992 1893-61 173 Ryan T.J. Cutaneous vasculitis. Champion R.H., Burton J.L., Burns D.A., Breathnach S.M. Textbook of Dermatology.

London

Blackwell Science 1998 2155-225 174 Sais G., Vidaller A., Jucgla A., Concom E., Peyri J. Adhesion molecule expression and endothelial cell activation in cutaneous leukocytoclastic vasculitis. An immunohistologic and clinical study in 42 patients. Arch. Derm. 1997 133 443-50 175 Salmon J.E., Brogle N.L., Edberg J.C., Kimberly R.P. Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II. J. Immunol. 1991 146 997-1004 176 Samlaska C.P., Winfield E.A. Pentoxifylline. J. Am. Acad. Dermatol. 1994 30 603-21 177 Sams W.M., Thorne E.G., Small P., Mass M.F., McIntosh R.M., Stanford R.E. Review Article: Leukocytoylastic Vasculitis. Arch. Dermatol. 1976 112 219-26 178 Sams W.M. Jr. Necrotizing vasculitis. J. Am. Acad. Dermatol. 1980 3 1-13 179 Sams W.M. Hypersensitivity angiitis. J. Invest. Dermatol. 1989 93 78-81 180 Sanchez N.P., VanHale H.M., Su W.P.D. Clinical and histopathological spectrum of necrotizing vasculitis. Arch. Dermatol. 1985 121 220-4 181 Sanui H., Yoshida S.-I., Nomoto K., Ohhara R., Adachi Y. Peritoneal macrophages which phagocytose autologous polymorphonuclear leucocytes in guinea pigs. Br. J. Pathol. 1982 63 278-85 182 Sato T., Hanada M., Bodrug S., Irie S., Iwana N., Boise L.H., Thompson C.B., Golemis E., Fong L., Wang H.G., Reed J.C. Interactions among members of the Bcl-2 protein family analysed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. 1994 91 9238-42 183 Savill J.S., Wyllie, A.H., Henson, J.E., Walport, M.J., Henson, P.M., Haslett, C. Macrophage phagocytosis of aging neutrophils in inflammation. PCD in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 1989 83 865-75 184 Savill J.S., Henson P.M., Haslett C. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel 'charge sensitive' recognition mechanism. J. Clin. Invest. 1989 84 1518-27 185 Savill J., Smith J., Sarraf C., Ren Y., Abbott F., Rees A. Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. Kidney Int. 1992 42 924-36 186 Savill J.S. The fate of the neutrophil in vasculitis. Clin. Exp. Immunol. 1993 93 Suppl.1 2-5 187 Schifferli J.A., Ng Y.C, Peters D.K. The role of complement and its receptor in the elimination of immune complexes. N. Engl. J. Med. 1986 315 488-95 188 Schifferli J.A., Saurat J.-H., Woodley D.T. Cutaneous vasculitis. Ruiz-Maldonado R., Parish L.C., Beare J.M. Textbook of pediatric dermatology.

Philadelphia

Grune and Stratton 1989 654-61 189 Schlossman S., Bloumsell W., Gilks W., et al. White Cell Differentiation Antigens. Schlossman S., Bloumsell W., Gilks W., et al. Leucocyte Typing V

New York

Oxford University Press 1994 190 Seino K., Iwabuchi K., Kayagaki N., Miyata R., Nagaoka I., Matsuzawa A., Fukao K., Yagita H., Okumura K. Chemotactic activity of soluble Fas ligand against phagocytes. J. Immunol. 1998 161 4484-8 191 Shi Y., Honma M., Koizumi F. Cutaneous allergic vasculitis: clinicopathological characterization and identification of apoptosis. Pathol. Int. 1998 48 705-16 192 Smith J.A. Neutrophils, host defense and inflammation: a double-edged sword. J. Leukoc. Biol. 1994 56 672-86 193 Smith J.G Jr. Vasculitis. J. Dermatol. 1995 22 812-22 194 Soddu S., Blandino G., Scardigli R., Coen S., Marchetti A., Rizzo M.G., Bossi G., Cimino L., Crescenzi M., Sacchi A. Interference with p53 protein inhibits hematopoietic and muscle differentiation. J. Cell. Biol. 1996 134 193-204 195 Soter N.A., Mihm M.C., Gigli I., Dvorak H.F., Austen K.F. Two Distinct Patterns in cutaneous Necrotizing Angiitis. J. Invest. Dermatol. 1976 66 344-50 196 Soter N.A., Wolff S.M. Necrotizing vasculitis. Fitzpatrick T.B., Eisen A.Z., Wolff K., et al Dermatology in general medicine.

New York

McGraw-Hill 1987 1300-12 197 Stadler R., Ruszczak Z. Therapeutic guidlines in vasculitidis. Int. Angiol. 1995 14 188-96 198 Stalder T., Hahn S., Erb P. Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J. Immunol. 1994 152 1127-33 199 Stringer R.E., Hart C.A., Edwards S.W. Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival. Br. J. Haematol. 1996 92 169-75 200 Suda T., Nagata S. Purification and characterization of the Fas-ligand that induces apoptosis. J. Exp. Med. 1994 179 873-9 201 Sunderkötter C., Steinbrink K., Henseleit U., Nashan D., Kolde G. Experimental models of leukocytoclastic vasculitis: adhesion molecules and immune deposits. Abstract 589 J. Invest. Dermatol. 1994 102 202 Sunderkötter C., Kolde G. Cutaneous vasculitis Bos J.D. The Skin Immune System

Boca Raton-New York

CRC Press 1997 479-88 203 Swerlick R.A., Lawley T.J. Cutaneous vasculitis: its relationship to systemic disease. Med. Clin. North. America. 1989 73 1221-35 204 Sylvestre D.L., Ravetch J.V. Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 1994 265 1095-8 205 Szucs G., Kavai M., Kiss E., Csipo I., Szegedi G. Correlation of IgG Fc receptors on granulocytes with serum immune complex level in systemic lupus erythematosus. Scand. J. Immunol. 1995 42 577-80 206 Takasaki Y., Fishwild D., Tan E.M. Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera. J. Exp. Med. 1984 159 981-92 207 Tamura A., Katsumata M., Greene M.I., Yui K. Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell. Immunol. 1996 168 220-8 208 Tan E.M., Ogata K., Takasaki Y. PCNA/cyclin: a lupus antigen connected with DNA replication. J. Rheumatol. 1987 Suppl 13 89-96 209 Tanaka M., Suda T., Takahashi T., Nagata S. Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J. 1995 14 1129-35 210 Thyresson H.N., McDuffie F.C., Schroeter A.L. C3b receptor in normal human skin. J. Invest. Dermatol. 1981 77 353-7 211 Tosi M.F., Berger M. Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibiodies. J. Immunol. 1988 141 2097-103 212 Trauth B.C., Keesey J. Cell Death. In: Guide to Cell Proliferation and Apoptosis Methods. Boehringer Mannheim 35 213 Trump B.F., Berezesky, Osorino Vargas. Cell death and the disease process. The role of calcium. Bowen I. D., Lockshin R. A. Cell death in biology and pathology

London

Chapman and Hall 1981 209 214 Tsujimoto Y., Cossman J., Jaffe E., Croce C.M. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985 228 1440-3 215 Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes. Cells. 1998 3 697-707 216 Tsuyuki S., Bertrand C., Erard F., Trifilieff A., Tsuyuki J., Wesp M., Anderson G.P., Coyle A.J. Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways. J. Clin. Invest. 1995 96 2924-31 217 Van Der Vliet H.J., Wever P.C., Van Diepen F.N., Yong S.L., Ten-Berge I.J. Quantification of Bax/Bcl-2 ratios in peripheral blood lymphocytes, monocytes and granulocytes and their relation to susceptibility to anti-Fas (anti-CD95)-induced apoptosis. Clin. Exp. Immunol. 1997 110 324-8 218 Van de Winkel J.G.J, Capel P.J.A. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 1993 14 215-21 219 Vignaux F., Vivier E., Malissen B., Depraetere V., Nagata S., Golstein P. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 1995 181 781-6 220 Ward C., Dransfield I., Chilvers E.R., Haslett C., Rossi A.G. Review Article: Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets. Trends Pharmacol. Sci. 1999 20 503-9 221 Watson R.W., O'Neill A., Brannigen A.E., Coffey R., Marshall J.C., Brady H.R., Fitzpatrick J.M. Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent. FEBS Lett. 1999 453 67-71 222 Weinmann P., Gaehtgens P., Walzog B. Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood 1999 93 3106-15 223 Weiss S.J. Tissue Destruction by neutrophils. New Eng. J. Med. 1989 320 365-75 224 Whyte M.K., Meagher L.C., MacDermot J., Haslett C. Impairment of function in aging neutrophils is associated with apoptosis. J. Immunol. 1993 150 5124-34 225 Wigbels B., Krebs S., Sorg C., Kolde G., Luger T.A., Sunderkötter C. Sequence of events in human leukocytoclastic Vasculitis. Abstract 671 J.Invest.Dermatol. 1997 108,4 649 226 Winkelmann R.K., Ditto W.B. Cutaneous and visceral syndromes of necrotizing or 'allergic' angiitis: A study of 38 cases. Medicine 1964 43 59-89 227 Witko-Sarsat V., Lesavre P., Lopez S., et al. A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J. Am. Soc. Nephrol. 1999 10 1224-33 228 Witthaut R. , Farhood A. , Smith C.W., Jaeschke H. Complement and tumor necrosis factor-alpha contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukoc. Biol. 1994 55 105-11 229 Wyllie A.H., Kerr J.F.R., Currie A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 1980 68 251-306 230 Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993 366 701-4 231 Xu H., Gonzalo J.A., St. Pierre Y., Williams I.R., Kupper T.S., Cotran R.S., Springer T.A., Gutierrez-Ramos J.C. Leukocytosis and resistance septic shock in intercellular adhesion molecule 1-deficient mice. J. Exp. Med. 1994 180 95-109 232 Zakeri Z.F., Quaglino D., Latham T., Lockshin R.A. Delayed internucleosomal DNA fragmentation in programmed cell death. FASEB J. 1993 7 470-8 233 Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gomez-Monterrey I., Castedo M., Kroemer G. Mitochondrial control of nuclear apoptosis [see comments] J. Exp. Med. 1996 183 1533-44 234 Zax R.H., Hodge S.J., Callen J.P. Cutaneous leukocytoclastic vasculitis. Serial histopathologic evaluation demonstrates the dynamic nature of the infiltrate. Arch. Dermatol. 1990 126 69-72