Molekulargenetische Identifizierung von Determinanten der Photoparoxysmalen ReaktionSusanne LorenzZusammenfassung123Einleitung34Methoden4Klinische Charakterisierung 5Genome scan nach PPR Determinanten6KandidatengenstudienSequenzanalyse des ALDH5A1 GensAssoziationsstudien 7ErgebnisseGenome scan nach PPR Determinanten (Tauer et al., 2005)789Positionelle Kandidatengene in der Region 6p21Kandidatengen ALDH5A1 (Lorenz et al., 2006a)10Kandidatengen BRD2 (Lorenz et al., 2006b)Replikationsstudien von positionellen und funktionellen Kandidatengenen GABRD Arg220His-Variation (Lenzen et al., 2005a) KCNJ10 Arg271Cys-Variation (Lenzen et al., 2005b)11 ME2-Risikohaplotyp (Lenzen et al., 2005c)Diskussion1112Genome scan nach PPR Determinanten (Tauer et al., 2005)Positionelle Kandidatengen Studien in der Region 6p21 (Lorenz et al., 2006a,b)1314Replikationsstudien von funktionellen Kandidatengenen GABRD Arg220His-Variation (Lenzen et al., 2005a)15 KCNJ10 Arg271Cys-Variation (Lenzen et al., 2005b) ME2-Risikohaplotyp (Lenzen et al., 2005c)16Perspektiven von molekulargenetischen ForschungsansätzenSelbständigkeitserklärung Publikationsliste: LiteraturverzeichnisdeInhaltsverzeichnisHilfe Literaturverzeichnis 1. 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