Märten, Angela: Tumorantigen gepulste dendritische Zellen zur Steigerung der Zytotoxizität immunologischer Effektorzellen bei Tumoren des gastroenteropankreatischen Systems

Bibliographie

Aicher, A.; Westermann, J.; Cayeux, S.; Willimsky, G.; Daemen, K.; Blankenstein, T.; Uckert, W.; Dörken, B. and A. Pezzutto. 1997. ""Successful retroviral mediated transduction of a reporter gene in human dendritic cells: Feasibility of therapy with gene-modified antigen presenting cells" ." Exp. Hematol. 25: 39-44.

Alters, S.E.; Gadea, J.R. and R. Philip. 1997. "Immunotherapy of cancer: Generation of CEA specific CTL using CEA peptide pulsed dendritic cells" .“ Dendr. Cells Fund. Cli. Immunol. 519-524.

Alters, S.E.; Gadea, J.R., Sorich, M.; O‘Donoghue, G.; Talib, S. and R. Philip . 1998. "Dendritic cells pulsed with CEA peptide induce CEA-specific CTL with restricted TCR repertoire" .“ J. Immunother. 21 (1): 17-26.

Altman, J.D.; Moss, P.A.H.; Goulder, P.J.R.; Barouch, D.H.; McHeyzer-Williams, M.G.; Bell, J.I.; McMichael, A.J. and M.M. Davis. 1996. "Phenotypic analysis of antigen-specific T lymphocytes" . Science. 274: 94-96.

Bakker, A.B.; Marland, G.; de Boer, A.J.; Huijbens, R.J.; Danem, E.H.; Ademan, .J. and C.G. Figdor. 1995. "Generation of anti-melanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-asssociated antigen-derived epitopes by dendritic cells in vitro." Cancer Res. 55: 5330-5334.

Bancherau, J. and R.M. Steinman . 1998. ’’"Dendritic cells and the control of immunity" ." Nature. 392: 246-252.

Barth, R.J.; Camp, B.J.; Martuscello, T.A.; Dain, B.J. and V.A. Memoli . 1996. ""The cytokine microenviroment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival" ." Cancer. 78: 1168-1178.

Bean, P. and A. Mazumder. 1992. "“Resistance of different tumor cells to lysis by lymphokine activated killer cells can be mediated by distinct mechanisms" .“ Immunbiology. 185: 63-.

Bergelson, J.M.; Cunningham, J.A.; Droguett, G.; Kurt-Jones, E.A.; Krithivas, A.; Hong, J.S.; Horwitz, M.S.; Crowell, R.L. and R.W. Finberg . 1997. ""Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5." " Science. 275: 1320-1323.

Birnboim, H.C. and J. Doly .1979 ". „A rapid alkaline extraction procedure for screening recombinant plasmid DNA" .“ Nucleic Acids Res. 7 (6): 1513-1523.

Boczkowski, D.; Nair, S.K.; Snyder, D. and E. Gilboa . 1996. ""Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo" ." J. Exp. Med. 184: 465-472.

Boon, T., Cerottini, J.C.; Van Der Bruggen, P. and A. Van Pel . 1994". "Tumor antigens recognized by T lymphocytes" ." Annu. Rev. Immunol. 12: 337-365.

Boss, J.M . 1997. ""Regulation of transcription of MHC class II genes" ." Curr. Opin. Immunol. 9 (1): 107-113.

Bøyum, A. 1964. ""Separation of white blood cells" ." Nature. 204 (793): 106-113.

Brossart, P.; Stuhler, G.; Heinrich, K.S.; Behnke, L.; Reichardt, V.L.; Stefanovic, S.; Rammensee, H.-G.; Lanz, K. and W. Brugger. 1999. ""Vaccination therapy of patients with metastatic breast and ovarian carcinoma using peptide pulsed dendritic cells."" ASCO.

Bubenick, J. 1996. ""Gene transfer for immunotherapy of cancer" ." Gene Ther. 3: 944-945.

Caux, C.; Vanbervliet, B.; Maasacrier, C.; Dezutter-Dambuyant, C.; de Saint-Vis, B.; Jacquet, C.; Yoneda, K.; Imamura, S.; Schmitt, D. and J. Bancherau. 1996. "„CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF and TNFalpha" .“ J. Exp. Med. 184: 695-706.


54

Cella, M.; Sallusto, F. and A. Lanzavecchia. 1997". "Origin, maturation and antigen presenting function of dendritic cells" ." Curr. Op. Immunol. 5: 10-16.

Chang, C.H.; Guerder, S.; Hong, S.C.; van Ewijk, W. and RA Flavell . 1996. ""Mice lacking CIITA show tissue-specific impairement of MHC class II expression" ." Immunity. 4 (29): 167-178.

Cheever, M.A.; Disis, M.L.; Bernhard, H.; Gralow, J.R.; Hand, S.L.; Huseby, E.S.; Qin, H.L.; Takahashi, M. and W. Chen. 1995. ""Immunity to oncogenic proteins" ." Immunol. Rev. 145: 33-59.

Chin, K.C.; Li, G.X. and J.P.Y.Ting . 1997. ""Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants" ." Proc. Natl. Acad. Sci. 94: 2501-2506.

Chomczynski, P. and N. Sacchi . 1987. ""Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction" ." Anal. Biochem. 162 (1): 156-159.

Cristiano, R.J.; Smith, L.C.; Kay, M.A.; Brinkley, B.R. and S.L. Woo. 1993. ’’"Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex." Proc. Natl. Acad. Sci. 90: 11548-11552.

Cook, J.A. and J.B. Mitchell . 1987. ""Viability measurements in mammalian cell systems" ." Anal. Biochem. 179 (1): 1-7.

Csipai, M.; Lefterova, P.; Finke, S.; Jonsthon, V.; Scheffold, C.; Huhn, D. and I.G.H. Schmidt-Wolf. 1996. ""Effects of interleukin-7 on proliferation of tumor cells" ." Canc. Res. Ther. Cont. 5: 11-16.

Denzin, L.K. and P. Creswell. 1995. ""HLA-DM induces CLIP dissociation from MHC class II dimers and facilitates peptide loading" ." Cell. 82: 155-165.

Di Nicola, M.; Siena, S.; Bregni, M.; Longoni, P.;Magni, M.; Milanesi, M.; Matteuci, P.; Mortarini, R.; Anichini, A.; Parmiani, G.; Drexler, I.; Erfle, V.; Sutter, G. and A.M. Gianni. 1997. ""Gene transfer into human dendritic antigen-presenting cells by vaccinia and adenovirus vectors" ." Cancer Gene Ther. 5 (6): 350-356.

Diao, J.; Smythe, J.A.; Rowe, P.B. and I.E. Alexander . 1999". "Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro." " Gene Ther. 6: 845-853.

Diebold, S.; Lehrmann, H.; Kursa, M.; Wagner, E.; Cotten, M. and M. Zenke . 1999. ""Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection."" Hum. Gene Ther. 10: 775-786.

Dietz, A.B. and S. Vuc-Pavlovic . 1998". "High efficiency adenovirus-mediated gene transfer to human dendritic cells" ." Blood. 91 (2): 392-398.

Dityaktin, S.Y.; Lisovskaya, K.V.; Panzhava, N.N.; and B.N. Iliashenko . 1972. "’’Frozen-thawed bacteria as recipients of isolated coliphage DNA" .“ Biochem. Biophys. Acta. 281: 319-323.

Dranoff, G. and R.C. Mulligan . 1995. ""Gene transfer as cancer therapy" ." Adv.Immunol. 58: 417-454.

Egner, W.; McKenzie, J.L.; Smith, S.M.; Beard, M.E.J. and D.N.J.Hart . 1993. ""Identification of potent mixed leucocyte reaction-stimulatory cells in human bone marrow."" J. Immunol. 150: 3043-3047.

Fanger, N.A.; Wardwell, K.; Shen, L.; Tedder, T.F. and P.M. Guyre . 1996. ""Type I (CD64) and type II (CD32) FC-gamma? receptor mediated phagocytosis by human blood dendritic cells" ." J. Immunol. 157: 541-545.

Fremont, D.H.; Hendrickson, W.A.; Marrack, P. and J. Kappler . 1996". "Structures of an MHC class II molecule with covalently bound single peptides." " Science. 272: 1001-1004.

Gabrilovich, D.; Oyama, T.; Ishida, T. and D. Carbone . 1998. "Defective dendritic cell function in cancer patients-improving the efficacy of vaccine therapy" .“ ASCO. 463-466.


55

Gilboa, E.and H.K. Lyerly . 1994". "Specific active immunotherapy of cancer using genetically modified tumor vaccines." " Biol. Ther. Cancer Upd. 1-16.

Gilboa, E.; Nair, S.K. and K. Lyerly . 1998.’’"Immunotherapy of cancer with dendritic cell-based vaccines" .“ Cancer Immunol. Immunother. 46 (2): 82-87.

Gold, P.and SO Freedman . 1965. ""Demonstration of tumour specific antigens in human colon carcinomatas by immunological tolerance and absorption techniques" ." J. Exp. Med. 121: 439-462.

Gong, J.; Chen, L.; Kashiwaba, M.; Moanome, Y., Tanaka, T. and D. Kufe . 1997. ""Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells" ." Gene Ther. 4: 1023-1028.

Greten, T.F.; Slansky,, J.E.; Kubota, R.; Soldan, S.S.; Jaffee, E.M.; Leist, T.M.;Pardoll, D.M.; Jacobson, S. and J.P. Schneck . 1998. ""Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients" ." Proc. Natl. Acad. Sci. 95 (13:) 7568-7573.

Grimm, E.A.; Mazunder, A.; Zhang, H.Z. and S.A. Rosenberg . 1982". „Lymphokine activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes." J. Exp. Med. 155: 1823-1841.

Haglund, C.; Roberts, P.J.; Kuusela, P.; Scheinin, T.M.; Makela, O. and H. Jalanko . 1986. ""Evaluation of CA 19-9 as a serum tumour marker in pancreatic cancer" ." Br. J.Cancer. 53: 197-202.

Hart, D.N.J . 1997. ""Dendritic cells: unique leucocyte populations which control the primary immune response." " Blood. 90 (9): 3245-3287.

Höltl, L.; Rieser, C.; Papesh, C.; Ramoner, R.; Bartsch, G. and M. Thurnher . 1998. ""CD83+ blood dendritic cells as a vaccine for immuntherapy of metastatic renal-cell cancer" ." Lancet. 352: 1358.

Hsu, F.J.; Benike, C.; Fagnoni, F.; Liles, T.M.; Czerwinski, D.; Taidi, B.; Engleman E.G. and R. Levy . 1996. "Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells" .“ Nature Med. 2 (1):52-57.

Inaba, K.; Metlay, J.P.; Crowley, M.T. and R.M. Steinman . 1990. ’’"Dendritic cells pulsed with protein antigen in vitro can prime antigen-specific, MHC-restricted T cells in situ" ." J. Exp. Med. 172: 631-640.

Inaba, K.; Inaba, M.; Romani, N.; Hideki, A.; Deguchi, M.; Ikehara, S.; Muramatsu, S. and R.M. Steinman . 1992. ""Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with GM-CSF" .“ J. Exp. Med. 176: 1693-1698.

Inaba, K.; Young, J.W. and R.M. Steinman . 1987". "Direct activation of CD8+lymphocytes by dendritic cells" ." J. Exp. Med. 166: 182-194.

Jill, F.A.; Butterfield, L.H.; Roth, M.D.; Bui, L.A.; Kiertscher, S.M.; Lau, R.; Dubinett, S.; Glaspy, J.; McBride, W.H. and J.S. Economou . 1997". "A comparison of gene transfer methods in human dendritic cells." " Cancer Gene Ther. 4 (1): 17-25.

Kemmner, W.; Schlag, P. and R. Brossmer . 1987". "A rapid and simple procedure for dissociation of tumor tissue from the human colon" ." J. Cancer Res. Clin. Oncol. 113 (4): 400-401.

Lanier, L.L.; Le, A.M.; Calvin, C.I.; Loken, M.R. and J.H. Philips . 1986. ""The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." " J. Immunol. 136: 4480-4486.

Lanzavecchia, A . 1998. „Licence to kill.“ Nature. 393: 413-414.


56

Lee, P.P.; Yee, C.; Savage, P.A.; Fong, L.; Brockstedt, D.; Weber, J.S.; Johnson, D.; Swetter, S.; Thompson, J.; Greenberg, P.D.; Roedere, M. and M.M. Davis . 1999. "Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients." Nature Med. 5 (6): 677-685.

Lotze, M.T.; Strausser, J.L. and S.A. Rosenberg . 1980. ""The in vivo distribution of autologous human and murine lymphoid cells-grown in T cell growth factor (TCGF) Implications for the adoptive immunotherapy of tumors" ." J. Immunol. 125: 1487-1493.

Low, M.G. and A.R.S. Prasad . 1988. ""A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma" ." Proc. Natl. Acad. Sci. 1988. 85: 980-984.

Lu, P.H.and R.S. Negrin . 1994. ""A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with SCID" ." J. Immunol. 153 (4:) 1687-1696.

Mackiewicz, A. and S. Rose-John . 1998. ""More about genetically modified tumour vaccines" ." Gene Ther. 5: 147-148.

Maeurer, M.J.; Gollin, S.M.; Martin, D.; Swaney, W.; Bryant, J.; Castelli, C.; Robbins, P.; Parmiani, G.; Storkus, W.J. and M.T. Lotze . 1996. ""Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen" ." J. Clin. Invest. 98: 1633-1641.

Margolin, K.A.; Negrin, R.S.; Wong, K.K.; Chatterjee, S.; Wright, C. and S.J. Forman . 1997". „Cellular immunotherapy and autologous transplantation for hematologic malignancy." “ Imm. Rev. 157: 231-240.

Martin, B.K.; Keh-Chuang, C.; Olsen, J.C.; Skinner C.A.; Dey, A.; Ozata, K. and J.P.Y.Ting . 1997. ""Induction of MHC class I expression by the MHC class II transactivator CIITA" ." Immunity. 6: 591-600.

Moore, K.W.; O'Garra, A.; Vieira, P. and T.R. Mosman . 1993.’’"Interleukin-10" .“ Annu. Rev. Immunol. 11: 165-190.

Morel, A.; Quaratino, S.; Douek; D.C. and M. Londei . 1997. ""Split activity of interleukin-10 on antigen capture and antigen presentation by human dendritic cells: definition of a maturative step" ." Eur. J. Immunol. 27: 26-31.

Mulders, P.; Pang, S.; Dannull, J.; Kaboo, R.; Hinkel, A.; Michel, K.; Tso, C.; Roth, M. and A. Belldegrun . 1998. ""Highly efficient and consistent gene transfer into dendritic cells utilizing a combination of ultraviolet-irradiated adenovirus and Poly(L-)Lysine conjugates" ." Cancer Res. 58: 956-961.

Mule, J.J.; Schwarz, S.L. and S.A. Rosenberg . 1984. ""Adoptive immunotherapy of established pulmonary metastases with LAK-cells and recombinant IL 2" ." Science. 225: 1487-1489.

Murphy, G.; Tjoa, B.; Ragde, H.; Kenny, G. and A. Boynton . 1996. ""Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201 specific peptides from prostate-specific membrane antigen" ." Prostate. 29: 371-380.

Nair, S.; Rouse, B.T.; Snyder, D. and E. Gilboa . 1997. ""Regression of tumors in mice vaccinated with professional antigen presenting cells pulsed with tumor extracts" ." Cancer. 70: 706-715.

Natali, P.G.; Nicotra, M.R.; Bigotti, A.; Venturo, I.; Marcenaro, L.; Giacomini, P. and C.Russo . 1989. ""Selective changes in expression of HLA class I polymorphic determinants in human solid tumors" ." Proc. Natl. Acad. Sci. 86: 6719-6723.

Nestle, F.O.; Alijagic, S.; Gilliet, M.; Sun, Y.; Grabbe, S.; Dummer, R.; Burg, G. and D. Schadendorf . 1998. ""Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells." " Nature Med. 4 (3): 328-332.


57

Öbrink, B . 1997". "CEA adhesion molecules: multifunctional proteins with signal-regulatory properties." " Curr. Opin. Cell. Biol. 616-626.

Parmiani, G . 1993. ""Tumor immunity as auto immunity: Tumor antigens include normal self-proteins which stimulate anergic peripheral T cells" ." Immunol. Today. 14: 536-538.

Peiper, M.; Goedegebuure, P.S. and T.J. Eberlein . 1997". „Generation of peptide-specific cytotoxic T lymphocytes using allogenic dendritic cells capable of lysing human pancreatic cancer cells." Surgery. 122 (2): 235-242.

Philip, R.; Brunette, E.; Ashton, J.; Alters, S.; Gadea, J.; Sorich, M.; Yau, J.; O‘Donoughue, G.; Lebkowski, J.; Okarma, T. and M. Philip . 1997. "„Transgene expression in dendritic cells to induce antigen-specific cytototoxic T cells in healthy donors" .“ Cancer Gene Ther. 5 (4). 236-246

Reichhardt, V.L.; Okada, C.Y.; Liso, A.; Benike, C.J.; Stockerl-Goldstein, K.E.; Engleman, E.G.; Blume, K.G. and R. Levy . 1999. "„Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma-a feasibility study" .“ Blood. 93 (7): 2411-2419.

Ridge, J.P.; Di Rosa, F. and P. Matzinger . 1998. ""A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell" ." Nature. 393: 474-477.

Romani, N.; Gruner, S.; Brang, D.; Kämpgen, E.; Lenz, A.; Trockenbacher, B.; Konwalinka, G.; Fritsch, P.O.; Steinman, R.M. and G. Schuler . 1994 "„Proliferating dendritic cell progenitors in human blood" .“ J. Exp. Med. 180: 83-93.

Romani, N.; Reider, D.; Heuer, M.; Ebner, S.; Kampgen, E.; Eibl, B.; Niederwieser, D.and G.S.O. Schuler . 1996. ""Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability."" Immunol. Methods. 196 (2): 137-151.

Rosenberg, S.A.; Spiess, P.S. and R.Lafreniere . 1986. ""A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes" ." Science. 233: 1318-1321.

Rosenberg, S.A . 1992. ""The immunotherapy and gene therapy of cancer" ." J. Clin. Oncol. 10: 180-199.

Rosenberg, S.A.; Kawakarni, Y.; Robbins, P.F. and R.F. Wang . 1996. ""Identification of the genes encoding cancer antigens: implications for cancer immunotherapy" ." Adv. Cancer Res. 10: 145-177.

Sallusto, F. and A. Lanzavecchia . 1994. ""Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor alpha." " J. Exp. Med. 179: 1109-1114.

Sallusto, F. and A. Lanzavecchia .1994b. „"Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen to the MHC class II compartment. Downreguation by cytokines and bacterial products." " J. Exp. Med. 182: 389-400.

Saraya, K. and C.D.L. Reid. 1996. ""Stem cell factor and the regulation of dendritic cell production from CD34+ progenitors in bone marrow and cord blood" ." Br. J. Haematol. 93: 258-264.

Schlom, J . 1995. ""Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine."" J. Natl. Canc. Inst. 87: 982-990.

Schmidt, R.E.; Murray, C.; Daley, J.F.; Schlossman, S.F. and J. Ritz . 1986". "A subset of natural killer cells in peripheral blood displays a mature T cell phenotype." " J. Exp. Med. 164: 351-357.

Schmidt-Wolf, I.G.H.; Negrin, R.S.; Kiem, H.P.; Blume, K.G. and I.L. Weissmann . 1991. ""Use of a SCID mouse/human lymphoma model to evaluate cytokine induced killer cells with potent anti-tumor cell activity" ." J. Exp. Med. 174: 139-149.


58

Schmidt-Wolf, I.G.H.; Lefterova, P.; Mehta, B.A.; Fernandez, L.P.; Huhn, D.; Blume, K.G.; Weissmann, I.L. and R. Negrin . 1993. ""Phenotypic characterization and identification of effector cells involved in tumor recognition of cytokine-induced killer cells" ." Exp. Hematol. 21: 1673-1679.

Schmidt-Wolf, I.G.H., Lefterova, P.; Johnston, V.; Neubauer, A.; Huhn, D.; Negrin, R. and K.G.Blume . 1994. ""Propagation of T cells with NK cell marker" ." Br. J. Haematol. 87: 453-458.

Schmidt-Wolf, I.G.H.; Neubauer, A.; Finke, S.; Csipai, M.; Wittig, B. and D. Huhn . 1994b". "Interleukin-7 gene therapy for patients with metastatic colon cancer, renal cell cancer, malignant melanoma or lymphoma" ." Hum. Gene Ther. 5: 1161-1169.

Schmoll, H.J.; Höffken, K. und K. Possinger . 1997. ""Kompendium Internistische Onkologie" ." 694-759; 810-830.

Schuler, G. and R.M. Steinman . 1997". "Dendritic cells as adjuvants for immune-mediated resistance to tumors."" J. Exp. Med. 186 (8): 1183-1187.

Seleznick, M.J . 1992. ""Tumor markers" ." Prim. Care. 19 (4): 715-726.

Sherman, M.A.; Weber, D.A. and P.E. Jensen. ""DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide" ." Immunity. 3: 197-205.

Steimle, V.; Otten, L.A.; Zufferey, M. and B. Mach . 1993. ""Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)."" Cell. 75 (1): 135-146.

Steinman, R.M. and Z.A. Cohn . 1972. ""The uptake, distribution and fate of soluble horseradish peroxidase in mouse peritoneal macrophages in vitro." " J. Cell. Biol. 55: 186-204.

Steinman, R.M. and Z.A. Cohn . 1973". "Identification of a novel cell type in peripheral lymphoid organs of mice." " J. Exp. Med. 137: 1142-1147.

Steinman, R.M . 1991. ""The dendritic cell system and its role in immunogenicity."" Annu. Rev. Immunol. 9: 271-296.

Szabolcs, P.; Gallardo, H.F.; Ciocon, D.H.; Sadelain, M. and J.W. Young . 1997".’’Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity."" Blood. 90 (6): 2160-2167.

Tarte, K.; Lu, Z.Y.; Fiol, G.; Legouffe, E.; Rossi, J.F. and B. Klein. 1997. "’’Generation of virtually pure and potentially proliferating dendritic cells from non-CD34 apheresis cells from patients with multiple myeloma." " Blood. 90 (9): 3482-3495.

Tendeloo, V.F.I. van; Snoeck, H.W.; Lardon, F.; Vanham, G.L.E.E.; Nijs, G.; Lenjou, M.; Hendriks, L.; Broeckhoven, C. van; Moulijn, A.; Rodrigus, I.; Verdonk, P.; Bockstaele, D.R. van and Z.N. Berneman . 1998. "’’Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells" ." Gene Ther. 5: 700-707.

Toribara, N.H. and M.H. Sleisinger . 1995. ""Screening for colorectal cancer."" N. Engl. J. Med. 332: 861-867.

Van Der Bruggen, P.; Traversari, C.; Chomez, P.; Lurquin, C.; De Plaen, E.; Van Den Eyde, B.; Knuth, A. and T. Boon . 1991. ""A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma" ." Science. 254: 1643-1647.

Van Pel, A. and T. Boon . 1982. ""Protection against a nonimmunogenic mouse leukemia by an immunogenic variant obtained by mutagenesis" ." Proc. Natl. Acad. Sci. 79: 4718-4722.

Versteegen, J.M.; Logtenberg, T. and R.E. Ballieux . 1998". „Enumeration of IFN-gamma-producing human lymphocytes by spot-ELISA. A method to detect lymphokine-producing lymphocytes at the single-cell level." J. Immunol. Methods. 111 (1): 25-29.


59

Westermann, J.; Aicher, A.; Qin, Z.; Daemen, K.; Blankenstein, T.; Dörken, B. and A. Pezzutto . 1998. ""Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation."" Gene Ther. 1998. 5: 264-271.

Wickham, T.J.; Mathias, P. and D. Cheresh . 1993. ""Integrins alphavbeta3 und alphavbeta5 promote adenovirus internalization but not virus attachment."" Cell. 73: 309-319.

Wong, C.; Morse, M. and S.K. Nair . 1997. "„Induction of primary human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides" ." J. Immunother. 21 (1): 32-40.

Wood, G.S.; Freudenthal, P.S.; Edinger, A.;Steinman R.M. and R.A. Warnke . 1991. ""CD45 epitope mapping of human CD1+ dendritic cells and peripheral blood dendritic cells" ." Am. J. Pathol. 138: 1451-1456.

Yeatman, T.J.; Duan, C.; Mao, W.; Karl, R.C. and J.Y. Djeu . 1995. ""Augmentation of carcinoembryonic antigen release from intact, viable tumor cells by a factor in human serum" ." Ann. Surg. Oncol. 2 (4): 336-342.

Zhang, W . 1999. ""Development and application of adenoviral vectors for gene therapy and cancer."" Cancer Gene Ther. 6 (2): 113-138.

Zoll, B.; Lefterova, P.; Csipai, M.; Finke, S.; Trojaneck, B.; Ebert, O.; Micka, B.; Roigk, K.; Fehlinger, M.; Schmidt-Wolf, G.D.; Huhn, D. and I.G. Schmidt-Wolf . 1998. ""Generation of cytokine-induced killer cells using exogenous interleukin-2, -7 or -12" ." Cancer Immunol. Immunother. 47 (4): 221-226.


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