Petersen, Simone: Identifizierung genetischer Läsionen in der Progression und Metastasierung von Bronchialkarzinomen


Adams JC (1997) "Thrombospondin" -1 . Int J Biochem Cell Biol 29: 861-865

Akiyama SK, Olden K & Yamada KM (1995) "Fibronectin and integrins in invasion and metastasis" . Cancer Metastasis Rev 14: 173-189

Alers JC, Krijtenburg PJ, Rosenberg C, Hop WC, Verkerk AM, Schroder FH, van der Kwast TH, Bosman FT & van Dekken H (1997) "Interphase cytogenetics of prostatic tumor progression: specific chromosomal abnormalities are involved in metastasis to the bone" . Lab Invest 77: 437-448

Alroy I & Yarden Y (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification "through" combinatorial ligand-receptor interactions. FEBS Lett 410: 83-86

Antoniades HN, Galanopoulos T, Neville-Golden J & O’Hara CJ (1992) Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF "receptor" mRNAs and their protein products . Proc Natl Acad Sci USA 89: 3942-3946

Bennett WP, Colby TV, Travis WD, Borkowski A, Jones Rt, Lane DP, Metcalf RA, Samet JM, Takeshima Y, Gu JR, Vähäkangas KH, Soini Y, Pääkkö P, Welsh JA & Harris CC (1993) p53 "protein" accumulates frequently in early bronchial neoplasia . Cancer Res 53: 4817-4822

Berta GN, Ghezzo F, D'Avolio A, Zulian P, Carbone V, Racca S, Vercellino V & Di Carlo F (1997) Enhancement of "calcyclin" gene RNA expression in squamous cell carcinoma of the oral mucosa, but not in benign lesions . J Oral Pathol Med 26: 206-210

Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WD, Cerny T & Thatcher N (1996) "Prognostic" significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer . Br J Cancer 73: 294-300

Birchmeier C & Gherardi E (1998 ) "Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase." Trends Cell Biol 8: 404-410

Bockmühl U, Schwendel A, Dietel M & Petersen I (1996) "Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas" . Cancer Res 56: 5325-5329

Bonomi P (1996) "Non-small cell lung cancer chemotherapy, In: Pass HI, Mitchell JB, Johnson DH and Turrisi AT (eds)" Lung Cancer: Principles and Practice. Philadelphia, Lippincott, p.811

Brambilla A, Negoescu A, Gazzeri S, Lantuejoul S, Moro D, Brambilla C & Coll JL (1996) "Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors." Am J Pathol 149: 1941-1952

Brinck U, Gabius HJ, Zeng FY, Gerke V, Lazarou D, Zografakis C, Tsambaos D & Berger H (1995) "Differential expression of calcyclin and its accessible ligands in various types of cutaneous tumors" . J Dermatol Sci 10: 181-190

Brison O (1993) "Gene amplification and tumor progression." Biochim Biophys Acta 1155: 25-41

Brodt P (1996) Cell adhesion and invasion in cancer metastasis , pp. 167-242, Landes, austin and Spronger, Berlin (1996)

Cagle PT, El-Naggar AK, Xu HJ, Hu SX & Benedict WF (1993) "Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications" . Am J Pathol 150: 393-400

Calabretta B, Battini R, Kaczmarek L, de Riel JK & Baserga R (1986a) "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein" . J Biol Chem 261: 12628-12632

Calabretta B, Venturelli D, Kaczmarek L, Narni F, Talpaz M, Anderson B, Beran M & Baserga R (1986b) "Altered expression of G1-specific genes in human malignant myeloid cells" . Proc Natl Acad Sci USA 83: 1495-1498

Cappellen D, Gil Diez de Medina S, Chopin D, Thiery JP & Radvanyi F (1997) "Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder" . Oncogene 14: 3059-3066

Caporaso NE, Hayes RB, Dosemici M, Hoover R, Ayesh R, Hetzel M & Idle J (1989) "Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype" . Cancer Res 49: 3675

Chambers AF & Tuck AB (1993) "Ras-responsive genes and tumor metastasis" . Crit Rev Oncog 4: 95-114

Chan CS & Botstein D (1993) "Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast." Genetics 135: 677-691

Chung GTY, Sudaresan V, Hasleton P, Rudd R, Taylor R & Rabbitts PH (1995) "Sequential molecular genetic changes in lung cancer development" . Oncogene 11: 2591-2598

Clements NC, Nelson MA, Wymer JA, Savage C, Aquirre M & Garewal H (1995) "Analysis of K-ras gene mutations in malignant and non-malignant endobronchial tissue obtained by fiberoptic bronchoscopy" . Am J Respir Crit Care Med 152: 1374-1378

Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) "Cloning and characterization of GRB14, a novel member of the GRB7 gene family." J Biol Chem 271: 12502-12510

Dameron KM, Volpert OV, Tainsky MA & Bouck N (1994) "Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1." Science 265: 1582-1584

Damstrup L, Rygaard K, Spang-Thomsen M & Poulsen HS (1992) "Expression of the epidermal growth receptor in human small cell lung cancer cell lines." Cancer Res 52: 3089-3093

Denissenko MF, Pao A, Tang M & Pfeifer GP (1996) "Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53" . Science 274: 430-432

DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA & Trent JM (1996) "Use of a cDNA microarray to analyse gene expression patterns in human cancer." Nat Genet 14: 457-460

De Vita VT, Hellmann S & Rosenberg SA (1997) Cancer: Principle and Practice of Oncology , 5. Ausgabe, Vol. 1, Lippincott-Raven, Philadelphia & New York, USA

Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED & Siebert PD (1996) "Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries" . Proc Natl Acad Sci U S A 93: 6025-6030

Drabkin HA, Mendez MJ, Rabbitts PH, Varkony T, Bergh J, Schlessinger J, Erickson P & Gemmill RM (1992) "Characterization of the submicroscopic deletion in the small-cell lung carcinoma (SCLC) cell line U2020" . Genes Chromosomes Cancer 5: 67-74

Du Manoir S, Speicher MR, Joos S, Schröck E, Popp S, Döhner H, Kovacs G, Robert-Nicoud M, Lichter P & Cremer T (1993) "Detection of complete and partial chromosome gain and losses by comparative genomic in situ hybridization" . Hum Genet 90: 590-610

Eerola AK, Törmänen U, Rainio R, Sormunen R, Bloigu R, Vähäkangas K, Lehto VP, Soini Y & Pääkkö P (1997) "Apoptosis in operated small cell lung carcinoma is inversly related to tumor necrosis and p53 immunoreactivity" . J Pathol 181: 172-177

Falciola L, Spada F, Calogero S, Langst G, Voit R, Grummt I & Bianchi ME (1997) "High mobility group 1 protein is not stably associated with the chromosomes of somatic cells" . J Cell Biol 137: 19-26

Fathi Z, Way JW, Corjay MH, Viallet J, Sausville EA & Battey JF (1996) "Bombesin receptor structure and expression in human lung carcinoma cell lines." J Cell Biochem Suppl 24: 237-246

Filipek A & Kuznicki J (1998) "Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin" . J Neurochem 70:1793-1798

Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, Ahmadian M, Ong ST, Rassool FV, Zimmermann PV, Giaccone G, Gazdar AF & Minna JD (1997) "FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations." Cancer Res 57: 2256-2267

Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, Basolo F & Bevilacqua G (1995) "Bcl-2 protein: a prognostic factor inversly correlated to p53 in non-small-cell lung cancer" . Br J Cancer 71: 1003-1007

Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, Milchgrub S, Brezinschek R, Virmani A, Gazdar AF & Minna JD (1998) "Mutation analysis of the PTEN/MMAC1 gene in lung cancer." Oncogene 17: 1557-1565

Glover DM, Leibowitz MH, McLean DA & Parry H (1995) "Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles" . Cell 81: 95-105

Goldfarb RH, Murano G, Brundage R, Siegal GP, Terranova V, Garbisa S & Liotta LA (1986) "Degradation of glycoprotein and collagenous components of the basement membrane: studies with urokinase-type plasminogen activator, alpha-thrombin, and plasmin" . Semin Thromb Hemost 12: 335-336

Grandori C & Eisenman RN (1997) "Myc target genes." Trends Biochem Sci 22: 177-181

Gray IC, Phillips SM, Lee SJ, Neoptolemos JP, Weissenbach J & Spurr NK (1995) "Loss of the chromosomal region 10q23-25 in prostate cancer" . Cancer Res 55: 4800-4803

Graziano SL (1997") Non-small cell lung cancer: clinical value of new biological predictors" . Lung Cancer 17: S37-S58

Greenblatt MS, Bennett WP, Hollstein M & Harris CC (1994) "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis" . Cancer Res 54: 4855-4878

Gronwald J, Storkel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J & Cremer T (1997)"Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events" . Cancer Res 57: 481-487

Guo XJ, Chambers AF, Parfett CL, Waterhouse P, Murphy LC, Reid RE, Craig AM, Edwards DR & Denhardt DT (1990) "Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells" . Cell Growth Differ 1: 333-338

Harbour JW, Lai SL, Whang-Peng J; Gazdar AF, Minna JD & Kaye FJ (1988) "Abnormalities in structure and expression of the human retinoblastoma gene in SCLC" . Science 241: 353-357

Herbst RA, Weiss J, Ehnis A, Cavenee WK & Arden KC (1994) "Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. " Cancer Res 54: 3111-3114

Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y & Takahashi T (1992") Three distinct regions involved in 3p deletion in human lung cancer." Oncogene 7: 445-449

Hirano T, Franzén B, Kato H, Ebihara Y & Auer G (1994") Genesis of squamous cell carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression" . Am J Pathol 144: 296-302

Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP & Weinberg RA (1990) "Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells" . Proc Natl Acad Sci USA 87: 2775-2779

Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire DD, Minna JD & Gazdar AF (1995) "Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma" . J Am Med Assoc 273: 558-563

Hynes R (1990) Fibronectins . Springer-Verlag, New York

Ichikawa T, Nihei N, Kuramochi H, Kawana Y, Killary AM, Rinker-Schaeffer CW, Barrett C, Isaacs JT, Kugoh H, Oshimura M & Shimazaki J (1996) "Metastasis suppressor genes for prostate cancer" . The Prostate Supplement 6: 31-35

Ittmann M (1996) "Allelic loss on chromosome 10 in prostate adenocarcinoma" . Cancer Res 56: 2143-2147

Jiang SX, Kameya T, Sato Y, Yanase N, Yoshimura H & Kodama T (1996) "Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation" . Am J Pathol 148: 837-846

Jiang SX, Sato Y, Kuwao S & Kameya T (1995) "Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas." J Pathol 177: 135-138

Kaiser U, Schili M, Haag U, Neumann K, Kreipe H, Kogan E & Havemann K (1996) "Expression of bcl-2-protein in small cell lung cancer" . Lung Cancer 15: 31-40

Kallioniemi A, Kallionemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F & Pinkel D (1992) "Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors" . Science 258: 818-821

Kayser K, Andre S, Bovin NV, Zeng FY & Gabius HJ (1997) "Preneoplasia-associated expression of calcyclin and of binding sites for synthetic blood group A/H trisaccharide-exposing neoglycoconjugates in human lung" . Cancer Biochem Biophys 15: 235-243

Kishimoto Y, Sugio K, Hung JY, Virmani AK, McIntire DD, Minna JD & Gazdar AF (1995) "Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers" . J Natl Cancer Inst 87: 1224-1229

Kitagawa Y, Wong F, Lo P, Elliott M, Verburgt LM, Hogg JC & Daya M (1996) "Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers" . Am J Respir Cell Mol Biol 15: 45-54

Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW & Burger PC (1995) "Histopathology, classification, and grading of gliomas" . Glia 15: 211-221

Kohno T, Kawanishi M, Matsuda S, Ichikawa H, Takada M, Ohki M, Yamamoto T & Yokota J (1998) "Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including the ANA gene in human lung carcinoma." Genes Chromosomes Cancer 21: 236-243

Komiya A, Suzuki H, Ueda T, Yatani R, Emi M, Ito H & Shimazaki J (1996) "Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer." Genes Chromosomes Cancer 17: 245-253

Konishi T, Lin Z, Fujino S, Kato H & Mori A (1997) "Association of p53 protein expression in stage I lung adenocarcinoma with reference to cytological subtypes" . Hum Pathol 28: 544-548

Konishi H, Takahashi T, Kozaki KI, Yatabe Y, Mitsudomi T, Fujii Y, Sugiura T, Matsuda H, Takahashi T & Takahashi T (1998) "Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers." Oncogene 17: 2095-2100

Krystal GW, Birrer M, Way J, Nau M, Sausville E, Thompson C, Minna JD & Battey J (1988) "Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer" . Mol Cell Biol 8: 3373-3381

Krystal GW, Hines SJ & Organ CP (1996) "Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor" . Cancer Res 56: 370-376

Kuukasjarvi T, Karhu R, Tanner M, Kahkonen M, Schaffer A, Nupponen N, Pennanen S, Kallioniemi A, Kallioniemi OP & Isola J (1997) "Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer" . Cancer Res 57: 1597-1604

Latif F, Tory K, Modi WS, Graziano SL, Gamble G, Douglas J, Heppell-Parton, Rabbitts PH, Zbar B & Lerman MI (1992") Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor gene" . Genes Chromosomes Cancer 5: 119-127

Leonard DG, Ziff EB & Greene LA (1987) "Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells" . Mol Cell Biol 7: 3156-3167

Levin NA, Brzoska P, Gupta N, Minna JD, Gray JW & Christman MF (1994) "Identification of frequent novel genetic alterations in small cell lung carcinoma." Cancer Res 54: 5086-5091

Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C & Parsons R (1997) "Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome" . Nat Genet 16: 64-67

Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH & Parsons R (1997) "PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer" . Science 275: 1943-1947

Lin H, Bondy ML, Langford LA, Hess KR, Delclos GL, Wu X, Chan W, Pershouse MA, Yung WK & Steck PA (1998) "Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance" . Clin Cancer Res 4: 2447-2454

Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova V & Garbisa S (1981) "Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane" . Cancer Res 41: 4629-4636

Li S, Rosell R, Urban A, Font A, Ariza A, Armengol P, Abad A, Navas JJ & Monzo M (1994) "K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma." Lung Cancer 11: 19-27

Li ZH, Zheng J, Weiss LM & Shibata D (1994") c-k-ras and p53 mutations occur very early in adenocarcinomas of the lung." Am J Pathol 144: 303-309

Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Moller P & King MC (1997) "Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis" . Am J Hum Genet 61: 1254-1260

Maier D, Zhang Z, Taylor E, Hamou MF, Gratzl O, Van Meir EG, Scott RJ & Merlo A (1998) "Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. " Oncogene 16: 3331-3335

Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB & Sidransky D (1995) "5‘CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers" . Nature Med 1: 686-692

Mertens F, Johansson B & Mitelman F (1994) "Isochromosomes in neoplasia" . Genes Chromosomes Cancer 10: 221-230

Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A & Poustka A (1997) "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. " Nature Gen 17: 32-39

Morita R, Saito S, Ishikawa J, Ogawa O, Yoshida O, Yamakawa K & Nakamura Y (1991) "Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma" . Cancer Res 51: 5817-5820

Nagase S, Sato S, Tezuka F, Wada Y, Yajima A & Horii A (1996) "Deletion mapping on chromosome 10q25-q26 in human endometrial cancer. " Br J Cancer 74: 1979-1983

Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW & Kremer H (1997) "Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease." Hum Mol Genet 6: 1383-1387

Nishio M, Koshikawa T, Kuroishi T, Suyama M, Uchida K, Takagi Y, Washimi O, Sugiura T Ariyoshi Y, Takahashi T, Ueda R & Takahashi T (1996) "Prognostic significance of abnormal p53 accumulation in primary, resected non-small cell lung cancers. " J Clin Oncol 14: 497-502

Noguchi-Takino M, Endo Y, Yonemura Y & Sasaki T (1996) "Relationship between expression of plasminogen activator system and metastatic ability in human cancers. " Int J Oncol 8: 97-105

Nuorva K, Soini Y, Kamel D, Autio-Harmainen H, Risteli L, Vähäkangas K & Pääkkö P (1993) "Concurrent p53 expression in bronchial dysplasias and squamous cell carcinomas" . Am J Pathol 142: 725-732

Olivero M, Rizzo M, Madeddu R, Casadio C, Pennacchietti S, Nicotra MR, Prat M, Maggi G, Arena N, Natali PG, Comoglio PM & Di Renzo MF (1996) "Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small cell lung carcinomas" . Br J Cancer 74: 1862-1868

Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE & Rothschild H (1986) "Increased familial risk for lung cancer." J Natl Cancer Inst 76: 217-222

Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M & Ikawa S (1998) "Cloning and functional analysis of human p51, which structurally and functionally resembles p53" . Nat Med 4: 839-843

Otterson GA, Khleif SN, Chen W, Coxon AB & Kaye FJ (1995) "CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2‘deoxycytidine" . Oncogene 11: 1211-1216

Paredes-Zaglul A, Kang JJ, Essig YP, Mao W, Irby R, Wloch M & Yeatman TJ (1998) "Analysis of colorectal cancer by comparative genomic hybridization: evidence for induction of the metastatic phenotype by loss of tumor suppressor genes." Clin Cancer Res 4: 879-886

Peeper DS, Upton TM, Ladha MH, Neumann E, Zalvide J, Bernhards R, DeCaprio JA & Ewen ME (1997) "Ras signaling linked to the cell-cycle machinery by the retinoblastoma protein" . Nature 382: 88-90

Petersen I, Langreck H, Wolf G, Schwendel A, Psille R, Vogt P, Reichel MB, Ried T & Dietel M (1997) "Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. " Br J Cancer 75: 79-86

Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC & Mason DY (1993) "bcl-2 protein in non-small cell lung carcinoma" . New Engl J Med 329: 690-694

Potts BC, Smith J, Akke M, Macke TJ, Okazaki K, Hidaka H, Case DA & Chazin WJ (1995) "The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins." Nat Struct Biol 2: 790-796

Rabbitts P, Bergh J, Douglas J, Collins F & Waters J (1990) "A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma." Genes Chromosomes Cancer 2: 231-238

Rachwal WJ, Bongiorno PF, Orringer MB, Whyte RI, Ethier SP & Beer DG (1995) "Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas" . Br J Cancer 72: 56-64

Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD & Bigner SH (1995) "Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25" . Oncogene 10: 2243-2246

Ray ME, Su YA, Meltzer PS & Trent JM (1996) "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma." Oncogene 12: 2527-2533

Ray ME, Wistow G, Su YA, Meltzer PS & Trent JM (1997) "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in humnan malignant melanoma. " Proc Natl Acad Sci USA 94: 3229-3234

Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes EC, Piantadosi S, Cordon-Cardo C & Slamon DJ (1993) "Inactivation of the retinoblastoma susceptibility gene in non-small cell lung cancer." Oncogene 8: 1913-1919

Richardson GE & Johnson BE (1993) "The biology of lung cancer." Semin Oncol 20: 105-127

Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schrock E, du Manoir S & Cremer T (1994) "Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization" . Cancer Res 54: 1801-1806

Robbins KC, Summaria L, Hsieh B & Shah RJ (1967) "The peptide chains of human plasmin, mechanism of activation system of human plasminogen to plasmin" . J Biol Chem 242: 2333-2342

Rodenhuis S & Slebos RJ (1992") Clinical significance of ras oncogene activation in human lung cancer. " Cancer Res 52: 2665s-2669s

Rosell R, Li S, Skacel Z, Mate JL, Maestre J, Canela M, Tolosa E, Armengol P, Barnadas A & Ariza A (1993) "Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients" . Oncogene 8: 2407-2412

Roth K, Wolf G, Dietel M & Petersen I (1997) "Image analysis for Comparative Genomic Hybridization (CGH) based on a karyotyping program for Windows" . Analytical and Quantitative Cytology and Histology 19: 461-474

Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, McIntosh J, Kurie J & Dmitrovsky E (1993") Differential expression of the epidermal growth factor receptor and ist ligands in primary non-small cell lung cancers and adjacent benign lung. " Cancer Res 53: 2379-2385

Rusin MR, Okamoto A, Chorazy M, Czyzewski K, Harasim J, Spillare EA, Hagiwara K, Hussain SP, Xiong Y, Demetrick DJ & Harris CC (1996) "Intragenic mutations of the p16INK4, p15INK4B and p18 genes in primary non-small-cell lung cancers" . Int J Cancer 65: 734-739

Sager R (1997) "Expression genetics in cancer: shifting the focus from DNA to RNA" . Proc Natl Acad Sci USA 94: 952-955

Sato S, Nakamura Y & Tsuchiya E (1994) "Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung" . Cancer Res 54: 5652-5655

Schena M, Shalon D, Davis RW & Brown PO (1995) "Quantitative monitoring of gene expression patterns with a complementary DNA microarray" . Science 270: 467-4670

Schneider PM, Hung MC, Chiocca SM, Manning J, Zhao X, Fang K & Roth JA (1989) "Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer" . Cancer Res 49: 4968-4971

Schwartz AG, Yang P & Swanson GM (1996) "Familial risk of lung cancer among nonsmokers and their relatives." Am J Epidemiol 144: 554-562

Schwendel A, Langreck H, Reichel M, Schröck E, Ried T, Dietel M & Petersen I (1997) "Primary small cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations" . Int J Cancer (Pred Oncol) 74: 86-93

Sekido Y, Fong KM & Minna JD (1998) "Progress in understanding the molecular pathogenesis of human lung cancer." Biochimica et Biophysica Acta 1378: F21-F59

Sekido Y, Takahashi T, Ueda R, Takahashi M, Suzuki H, Nishida K & Tsukamoto T (1993) "Recombinant human stemm cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene" . Cancer Res 53: 1709-1714

Sellers TA, Bailay-Wilson JE, Elston RC, Wilson AF, Elston GZ, Ooi WL & Rothschild H (1990) "Evidence for mendelian inheritance in the pathogenesis of lung cancer. " J Natl Cancer Inst 82: 1272-1279

Sen S, Zhou H & White RA (1997) "A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. " Oncogene 14: 2195-2200

Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ & Rollins BJ (1995) "Reciprocal RB inactivation and p16INK4 expression in primary lung cancers and cell lines" . Cancer Res 55: 505-509

Shaw GL, Falk RT, Deslauriers J, Frame JN, Nesbitt JC, Pass HI, Issaq HJ, Hoover RN & Tucker MA (1995) "Debrisoquine metabolism and lung cancer risk" . Cancer Epidemiol Biomarkers Prev 4: 41-48

Shi D, He G, Cao S, Pan W, Zhang HZ, Yu D & Hung MC (1992) "Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancer." Mol Carcinogen 5: 213-218

Shields PG & Harris CC (1993) "Genetic predisposition to cancer" , In: Roth JA, Cox JD and Hong WK (eds) Lung Cancer . Boston, Blackwell, p.3

Shimizu T & Sekiya T (1995) "Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers" . Int J Cancer 63: 616-620

Shiseki M, Kohno T, Adachi J, Okazaki T, Otsuka T, Mizoguchi H, Noguchi M, Hirohashi S & Yokota J (1996) "Comparative allelotype of early and advanced stage non-small cell lung carcinomas" . Genes Chromosomes Cancer 17:71-77

Siegfried JM, Weissfeld LA, Singh-Kaw P, Weyant RJ, Testa JR & Landreneau RJ (1997) "Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer." Cancer Res 75: 433-439

Slebos RJC, Evers SG, Wagenaar SS & Rodenhuis S (1989) "Cellular protooncogenes are infrequently amplified in untreated non-small cell lung cancer (NSCLC)." Br J Cancer 59: 76-80

Smith AL, Hung J, Walker L, Rogers TE, Vuitch F, Lee E & Gazdar AF (1996) "Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients" . Br J Cancer 73: 203-209

Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K & Croce CM (1996) "The FHIT gene 3p14.2 is abnormal in lung cancer." Cell 85: 17-26

Speaks SL, Sanger WG, Masih AS, Harrington DS, Hess M & Armitage JO (1992) "Recurrent abnormalities of chromosome bands 10q23-25 in non-Hodgkin's lymphoma" . Genes Chromosomes Cancer 5: 239-243

Steck PA, Ligon AH, Cheong P, Yung WK & Pershouse MA (1995) "Two tumor suppressive loci on chromosome 10 involved in human glioblastomas." Genes Chromosomes Cancer 12: 255-261

Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH & Tavtigian SV (1997) "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers." Nat Genet 15: 356-362

Sugio K, Kishimoto Y, Virmani AK, Hung JY & Gazdar AF (1994) K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. Cancer Res 54: 5811-5815

Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM & Rabbitts P (1992) "p53 and chromosome 3 abnormalities, characteristic of malignant lung tumors, are detectable in preinvasive lesions of the bronchus" . Oncogene 7: 1989-1997

Szallasi Z (1998) "Gene expression patterns and cancer" . Nat Biotechnology 16: 1292-1293

Tamura K, Zhang X, Murakami Y, Hirohashi S, Xu HJ, Hu SX, Benedict WF & Sekiya T (1997) "Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer" . Int J Cancer 74: 45-49

Tanaka H, Fujii Y, Hirabayashi H, Miyoshi S, Sakaguchi M, Yoon HE & Matsuda H (1998) "Disruption of the RB pathway and cell-proloferative activity in non-small-cell lung cancers." Int J Cancer 79: 111-115

Tanner MM, Tirkkonen M, Kallionemi A, Collins C, Stokke T, Karhu R, Kowbel D, Shadravan F, Hintz M, Kuo WL, Waldman FM, Isola JJ, Gray GW & Kallionemi OP (1994) "Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes." Cancer Res 54: 4257-4260

Tateishi M, Ishida T, Mitsudomi T, Kaneko S & Sugimachi K (1990) "Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the lung" . Cancer Res 50: 7077-7080

Thompson MA & Ziff EB (1989) "Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein" . Neuron 2: 1043-1053

Todd S, Franklin WA, Varella-Garcia M, Kennedy T, Hilliker Jr C, Hahner L, Anderson M, Wiest JS, Drabkin HA & Gemmill RM (1997) "Homozygous deletions of human chromosome 3p in lung tumors. " Cancer Res 57: 1344-1352

To-Figueras J, Gene M, Gomez J, Galan C, Firvida J, Fuentes M, Rodamilans M, Huguet E, Estape J & Corbella J (1996") Glutathione M1 and codon 72p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility." Cancer Epidemiol Biomarkers Prev 5: 337-342

Tonini GP, Casalaro A, Cara A & Di Martino D (1991) "Inducible expression of calcyclin, a gene with strong homology to S-100 protein, during neuroblastoma cell differentiation and its prevalent expression in Schwann-like cell lines" . Cancer Res 51: 1733-1737

Urtreger A, Porro F, Puricelli L, Werbajh S, Baralle FE, Bal de Kier Joffe E, Kornblihtt AR & Muro AF (1998) "Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis" . Int J Cancer 78: 233-241

van Groningen JJ, Weterman MA, Swart GW & Bloemers HP (1995) "Functional analysis of the human calcyclin gene promoter in a panel of human melanoma cell lines." Biochem Biophys Res Commun 213: 1122-1131

Velculescu VE, Zhang L, Vogelstein B & Kinzler KW (1995) "Serial analysis of gene expression. " Science 270: 484-487

Viallet J & Sausville EA (1996) "Involvement of signal transduction pathways in lung cancer biology. " J Cell Biochem Suppl 24: 228-236

Washimi O, Nagatake M, Osada H, Ueda H, Koshikawa T, Seki T, Takahashi T & Takahashi T (1995) "In vivo occurence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers" . Cancer Res 55: 514-517

Weiner DB, Nordberg J, Robinson R, Nowell PC, Gazdar A, Greene MI, Williams WV, Cohen JA & Kern JA (1990) "Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung" . Cancer Res 50: 421-425

Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Weissman BE & Stanbridge EJ (1994) "Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity." Oncogene 9: 255-262

Werbajh SE, Urtreger AJ, Puricelli LI, de Lustig ES, Bal de Kier Joffe E & Kornblihtt AR (1998) "Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells." FEBS Lett 440: 277-281

Weterman MA, van Muijen GN, Bloemers HP & Ruiter DJ (1993) "Expression of calcyclin in human melanocytic lesions. " Cancer Res 53: 6061-6066

Williams DE, Pairolero PC, Davis C, Bernatz PE, Payne WS, Taylor WF, Uhenhopp MA & Fontana RS (1981) "Survival of patients surgically treated for stage I lung cancer." J Thoracic Cardiovasc Surg 82: 70-76

Xiang YY, Wang DY, Tanaka M, Suzuki M, Kiyokawa E, Igarashi H, Naito Y, Shen Q & Sugimura H (1997) "Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa." Int J Cancer 74: 1-6

Xu HJ, Hu SX, Cagle PT, Moore GE & Benedict WF (1991) "Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas." Cancer Res 51: 2735-2739

Xu HJ, Quinlan DC, Davidson AG, Hu SX, Summers CL, Li J & Benedict WF (1994) "Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma" . J Natl Cancer Inst 86: 695-699

Yoshino H, Endo Y, Watanabe Y & Sasaki T (1998) "Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis" . Br J Cancer 78: 833-839

Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR & Sen S (1998) "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation." Nat Genet 20: 189-193

[Titelseite] [1] [2] [3] [4] [5] [6] [Abkürzungsverzeichnis] [Bibliographie] [Danksagung] [Selbständigkeitserklärung] [Anhang]

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