Petersen, Simone: Identifizierung genetischer Läsionen in der Progression und Metastasierung von Bronchialkarzinomen

Literaturverzeichnis

Adams JC (1997) "Thrombospondin" -1 . Int J Biochem Cell Biol 29: 861-865

Akiyama SK, Olden K & Yamada KM (1995) "Fibronectin and integrins in invasion and metastasis" . Cancer Metastasis Rev 14: 173-189

Alers JC, Krijtenburg PJ, Rosenberg C, Hop WC, Verkerk AM, Schroder FH, van der Kwast TH, Bosman FT & van Dekken H (1997) "Interphase cytogenetics of prostatic tumor progression: specific chromosomal abnormalities are involved in metastasis to the bone" . Lab Invest 77: 437-448

Alroy I & Yarden Y (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification "through" combinatorial ligand-receptor interactions. FEBS Lett 410: 83-86

Antoniades HN, Galanopoulos T, Neville-Golden J & O’Hara CJ (1992) Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF "receptor" mRNAs and their protein products . Proc Natl Acad Sci USA 89: 3942-3946

Bennett WP, Colby TV, Travis WD, Borkowski A, Jones Rt, Lane DP, Metcalf RA, Samet JM, Takeshima Y, Gu JR, Vähäkangas KH, Soini Y, Pääkkö P, Welsh JA & Harris CC (1993) p53 "protein" accumulates frequently in early bronchial neoplasia . Cancer Res 53: 4817-4822

Berta GN, Ghezzo F, D'Avolio A, Zulian P, Carbone V, Racca S, Vercellino V & Di Carlo F (1997) Enhancement of "calcyclin" gene RNA expression in squamous cell carcinoma of the oral mucosa, but not in benign lesions . J Oral Pathol Med 26: 206-210

Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WD, Cerny T & Thatcher N (1996) "Prognostic" significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer . Br J Cancer 73: 294-300

Birchmeier C & Gherardi E (1998 ) "Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase." Trends Cell Biol 8: 404-410

Bockmühl U, Schwendel A, Dietel M & Petersen I (1996) "Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas" . Cancer Res 56: 5325-5329

Bonomi P (1996) "Non-small cell lung cancer chemotherapy, In: Pass HI, Mitchell JB, Johnson DH and Turrisi AT (eds)" Lung Cancer: Principles and Practice. Philadelphia, Lippincott, p.811

Brambilla A, Negoescu A, Gazzeri S, Lantuejoul S, Moro D, Brambilla C & Coll JL (1996) "Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors." Am J Pathol 149: 1941-1952

Brinck U, Gabius HJ, Zeng FY, Gerke V, Lazarou D, Zografakis C, Tsambaos D & Berger H (1995) "Differential expression of calcyclin and its accessible ligands in various types of cutaneous tumors" . J Dermatol Sci 10: 181-190

Brison O (1993) "Gene amplification and tumor progression." Biochim Biophys Acta 1155: 25-41

Brodt P (1996) Cell adhesion and invasion in cancer metastasis , pp. 167-242, Landes, austin and Spronger, Berlin (1996)

Cagle PT, El-Naggar AK, Xu HJ, Hu SX & Benedict WF (1993) "Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications" . Am J Pathol 150: 393-400

Calabretta B, Battini R, Kaczmarek L, de Riel JK & Baserga R (1986a) "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein" . J Biol Chem 261: 12628-12632

Calabretta B, Venturelli D, Kaczmarek L, Narni F, Talpaz M, Anderson B, Beran M & Baserga R (1986b) "Altered expression of G1-specific genes in human malignant myeloid cells" . Proc Natl Acad Sci USA 83: 1495-1498

Cappellen D, Gil Diez de Medina S, Chopin D, Thiery JP & Radvanyi F (1997) "Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder" . Oncogene 14: 3059-3066

Caporaso NE, Hayes RB, Dosemici M, Hoover R, Ayesh R, Hetzel M & Idle J (1989) "Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype" . Cancer Res 49: 3675

Chambers AF & Tuck AB (1993) "Ras-responsive genes and tumor metastasis" . Crit Rev Oncog 4: 95-114

Chan CS & Botstein D (1993) "Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast." Genetics 135: 677-691

Chung GTY, Sudaresan V, Hasleton P, Rudd R, Taylor R & Rabbitts PH (1995) "Sequential molecular genetic changes in lung cancer development" . Oncogene 11: 2591-2598

Clements NC, Nelson MA, Wymer JA, Savage C, Aquirre M & Garewal H (1995) "Analysis of K-ras gene mutations in malignant and non-malignant endobronchial tissue obtained by fiberoptic bronchoscopy" . Am J Respir Crit Care Med 152: 1374-1378

Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) "Cloning and characterization of GRB14, a novel member of the GRB7 gene family." J Biol Chem 271: 12502-12510

Dameron KM, Volpert OV, Tainsky MA & Bouck N (1994) "Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1." Science 265: 1582-1584

Damstrup L, Rygaard K, Spang-Thomsen M & Poulsen HS (1992) "Expression of the epidermal growth receptor in human small cell lung cancer cell lines." Cancer Res 52: 3089-3093

Denissenko MF, Pao A, Tang M & Pfeifer GP (1996) "Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53" . Science 274: 430-432

DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA & Trent JM (1996) "Use of a cDNA microarray to analyse gene expression patterns in human cancer." Nat Genet 14: 457-460

De Vita VT, Hellmann S & Rosenberg SA (1997) Cancer: Principle and Practice of Oncology , 5. Ausgabe, Vol. 1, Lippincott-Raven, Philadelphia & New York, USA

Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED & Siebert PD (1996) "Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries" . Proc Natl Acad Sci U S A 93: 6025-6030

Drabkin HA, Mendez MJ, Rabbitts PH, Varkony T, Bergh J, Schlessinger J, Erickson P & Gemmill RM (1992) "Characterization of the submicroscopic deletion in the small-cell lung carcinoma (SCLC) cell line U2020" . Genes Chromosomes Cancer 5: 67-74

Du Manoir S, Speicher MR, Joos S, Schröck E, Popp S, Döhner H, Kovacs G, Robert-Nicoud M, Lichter P & Cremer T (1993) "Detection of complete and partial chromosome gain and losses by comparative genomic in situ hybridization" . Hum Genet 90: 590-610

Eerola AK, Törmänen U, Rainio R, Sormunen R, Bloigu R, Vähäkangas K, Lehto VP, Soini Y & Pääkkö P (1997) "Apoptosis in operated small cell lung carcinoma is inversly related to tumor necrosis and p53 immunoreactivity" . J Pathol 181: 172-177

Falciola L, Spada F, Calogero S, Langst G, Voit R, Grummt I & Bianchi ME (1997) "High mobility group 1 protein is not stably associated with the chromosomes of somatic cells" . J Cell Biol 137: 19-26

Fathi Z, Way JW, Corjay MH, Viallet J, Sausville EA & Battey JF (1996) "Bombesin receptor structure and expression in human lung carcinoma cell lines." J Cell Biochem Suppl 24: 237-246

Filipek A & Kuznicki J (1998) "Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin" . J Neurochem 70:1793-1798

Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, Ahmadian M, Ong ST, Rassool FV, Zimmermann PV, Giaccone G, Gazdar AF & Minna JD (1997) "FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations." Cancer Res 57: 2256-2267

Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, Basolo F & Bevilacqua G (1995) "Bcl-2 protein: a prognostic factor inversly correlated to p53 in non-small-cell lung cancer" . Br J Cancer 71: 1003-1007

Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, Milchgrub S, Brezinschek R, Virmani A, Gazdar AF & Minna JD (1998) "Mutation analysis of the PTEN/MMAC1 gene in lung cancer." Oncogene 17: 1557-1565

Glover DM, Leibowitz MH, McLean DA & Parry H (1995) "Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles" . Cell 81: 95-105

Goldfarb RH, Murano G, Brundage R, Siegal GP, Terranova V, Garbisa S & Liotta LA (1986) "Degradation of glycoprotein and collagenous components of the basement membrane: studies with urokinase-type plasminogen activator, alpha-thrombin, and plasmin" . Semin Thromb Hemost 12: 335-336

Grandori C & Eisenman RN (1997) "Myc target genes." Trends Biochem Sci 22: 177-181

Gray IC, Phillips SM, Lee SJ, Neoptolemos JP, Weissenbach J & Spurr NK (1995) "Loss of the chromosomal region 10q23-25 in prostate cancer" . Cancer Res 55: 4800-4803

Graziano SL (1997") Non-small cell lung cancer: clinical value of new biological predictors" . Lung Cancer 17: S37-S58

Greenblatt MS, Bennett WP, Hollstein M & Harris CC (1994) "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis" . Cancer Res 54: 4855-4878

Gronwald J, Storkel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J & Cremer T (1997)"Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events" . Cancer Res 57: 481-487

Guo XJ, Chambers AF, Parfett CL, Waterhouse P, Murphy LC, Reid RE, Craig AM, Edwards DR & Denhardt DT (1990) "Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells" . Cell Growth Differ 1: 333-338

Harbour JW, Lai SL, Whang-Peng J; Gazdar AF, Minna JD & Kaye FJ (1988) "Abnormalities in structure and expression of the human retinoblastoma gene in SCLC" . Science 241: 353-357

Herbst RA, Weiss J, Ehnis A, Cavenee WK & Arden KC (1994) "Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. " Cancer Res 54: 3111-3114

Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y & Takahashi T (1992") Three distinct regions involved in 3p deletion in human lung cancer." Oncogene 7: 445-449

Hirano T, Franzén B, Kato H, Ebihara Y & Auer G (1994") Genesis of squamous cell carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression" . Am J Pathol 144: 296-302

Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP & Weinberg RA (1990) "Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells" . Proc Natl Acad Sci USA 87: 2775-2779

Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire DD, Minna JD & Gazdar AF (1995) "Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma" . J Am Med Assoc 273: 558-563

Hynes R (1990) Fibronectins . Springer-Verlag, New York

Ichikawa T, Nihei N, Kuramochi H, Kawana Y, Killary AM, Rinker-Schaeffer CW, Barrett C, Isaacs JT, Kugoh H, Oshimura M & Shimazaki J (1996) "Metastasis suppressor genes for prostate cancer" . The Prostate Supplement 6: 31-35

Ittmann M (1996) "Allelic loss on chromosome 10 in prostate adenocarcinoma" . Cancer Res 56: 2143-2147

Jiang SX, Kameya T, Sato Y, Yanase N, Yoshimura H & Kodama T (1996) "Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation" . Am J Pathol 148: 837-846

Jiang SX, Sato Y, Kuwao S & Kameya T (1995) "Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas." J Pathol 177: 135-138

Kaiser U, Schili M, Haag U, Neumann K, Kreipe H, Kogan E & Havemann K (1996) "Expression of bcl-2-protein in small cell lung cancer" . Lung Cancer 15: 31-40

Kallioniemi A, Kallionemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F & Pinkel D (1992) "Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors" . Science 258: 818-821

Kayser K, Andre S, Bovin NV, Zeng FY & Gabius HJ (1997) "Preneoplasia-associated expression of calcyclin and of binding sites for synthetic blood group A/H trisaccharide-exposing neoglycoconjugates in human lung" . Cancer Biochem Biophys 15: 235-243

Kishimoto Y, Sugio K, Hung JY, Virmani AK, McIntire DD, Minna JD & Gazdar AF (1995) "Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers" . J Natl Cancer Inst 87: 1224-1229

Kitagawa Y, Wong F, Lo P, Elliott M, Verburgt LM, Hogg JC & Daya M (1996) "Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers" . Am J Respir Cell Mol Biol 15: 45-54

Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW & Burger PC (1995) "Histopathology, classification, and grading of gliomas" . Glia 15: 211-221

Kohno T, Kawanishi M, Matsuda S, Ichikawa H, Takada M, Ohki M, Yamamoto T & Yokota J (1998) "Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including the ANA gene in human lung carcinoma." Genes Chromosomes Cancer 21: 236-243

Komiya A, Suzuki H, Ueda T, Yatani R, Emi M, Ito H & Shimazaki J (1996) "Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer." Genes Chromosomes Cancer 17: 245-253

Konishi T, Lin Z, Fujino S, Kato H & Mori A (1997) "Association of p53 protein expression in stage I lung adenocarcinoma with reference to cytological subtypes" . Hum Pathol 28: 544-548

Konishi H, Takahashi T, Kozaki KI, Yatabe Y, Mitsudomi T, Fujii Y, Sugiura T, Matsuda H, Takahashi T & Takahashi T (1998) "Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers." Oncogene 17: 2095-2100

Krystal GW, Birrer M, Way J, Nau M, Sausville E, Thompson C, Minna JD & Battey J (1988) "Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer" . Mol Cell Biol 8: 3373-3381

Krystal GW, Hines SJ & Organ CP (1996) "Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor" . Cancer Res 56: 370-376

Kuukasjarvi T, Karhu R, Tanner M, Kahkonen M, Schaffer A, Nupponen N, Pennanen S, Kallioniemi A, Kallioniemi OP & Isola J (1997) "Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer" . Cancer Res 57: 1597-1604

Latif F, Tory K, Modi WS, Graziano SL, Gamble G, Douglas J, Heppell-Parton, Rabbitts PH, Zbar B & Lerman MI (1992") Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor gene" . Genes Chromosomes Cancer 5: 119-127

Leonard DG, Ziff EB & Greene LA (1987) "Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells" . Mol Cell Biol 7: 3156-3167

Levin NA, Brzoska P, Gupta N, Minna JD, Gray JW & Christman MF (1994) "Identification of frequent novel genetic alterations in small cell lung carcinoma." Cancer Res 54: 5086-5091

Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C & Parsons R (1997) "Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome" . Nat Genet 16: 64-67

Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH & Parsons R (1997) "PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer" . Science 275: 1943-1947

Lin H, Bondy ML, Langford LA, Hess KR, Delclos GL, Wu X, Chan W, Pershouse MA, Yung WK & Steck PA (1998) "Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance" . Clin Cancer Res 4: 2447-2454

Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova V & Garbisa S (1981) "Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane" . Cancer Res 41: 4629-4636

Li S, Rosell R, Urban A, Font A, Ariza A, Armengol P, Abad A, Navas JJ & Monzo M (1994) "K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma." Lung Cancer 11: 19-27

Li ZH, Zheng J, Weiss LM & Shibata D (1994") c-k-ras and p53 mutations occur very early in adenocarcinomas of the lung." Am J Pathol 144: 303-309

Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Moller P & King MC (1997) "Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis" . Am J Hum Genet 61: 1254-1260

Maier D, Zhang Z, Taylor E, Hamou MF, Gratzl O, Van Meir EG, Scott RJ & Merlo A (1998) "Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. " Oncogene 16: 3331-3335

Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB & Sidransky D (1995) "5‘CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers" . Nature Med 1: 686-692

Mertens F, Johansson B & Mitelman F (1994) "Isochromosomes in neoplasia" . Genes Chromosomes Cancer 10: 221-230

Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A & Poustka A (1997) "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. " Nature Gen 17: 32-39

Morita R, Saito S, Ishikawa J, Ogawa O, Yoshida O, Yamakawa K & Nakamura Y (1991) "Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma" . Cancer Res 51: 5817-5820

Nagase S, Sato S, Tezuka F, Wada Y, Yajima A & Horii A (1996) "Deletion mapping on chromosome 10q25-q26 in human endometrial cancer. " Br J Cancer 74: 1979-1983

Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW & Kremer H (1997) "Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease." Hum Mol Genet 6: 1383-1387

Nishio M, Koshikawa T, Kuroishi T, Suyama M, Uchida K, Takagi Y, Washimi O, Sugiura T Ariyoshi Y, Takahashi T, Ueda R & Takahashi T (1996) "Prognostic significance of abnormal p53 accumulation in primary, resected non-small cell lung cancers. " J Clin Oncol 14: 497-502

Noguchi-Takino M, Endo Y, Yonemura Y & Sasaki T (1996) "Relationship between expression of plasminogen activator system and metastatic ability in human cancers. " Int J Oncol 8: 97-105

Nuorva K, Soini Y, Kamel D, Autio-Harmainen H, Risteli L, Vähäkangas K & Pääkkö P (1993) "Concurrent p53 expression in bronchial dysplasias and squamous cell carcinomas" . Am J Pathol 142: 725-732

Olivero M, Rizzo M, Madeddu R, Casadio C, Pennacchietti S, Nicotra MR, Prat M, Maggi G, Arena N, Natali PG, Comoglio PM & Di Renzo MF (1996) "Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small cell lung carcinomas" . Br J Cancer 74: 1862-1868

Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE & Rothschild H (1986) "Increased familial risk for lung cancer." J Natl Cancer Inst 76: 217-222

Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M & Ikawa S (1998) "Cloning and functional analysis of human p51, which structurally and functionally resembles p53" . Nat Med 4: 839-843

Otterson GA, Khleif SN, Chen W, Coxon AB & Kaye FJ (1995) "CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2‘deoxycytidine" . Oncogene 11: 1211-1216

Paredes-Zaglul A, Kang JJ, Essig YP, Mao W, Irby R, Wloch M & Yeatman TJ (1998) "Analysis of colorectal cancer by comparative genomic hybridization: evidence for induction of the metastatic phenotype by loss of tumor suppressor genes." Clin Cancer Res 4: 879-886

Peeper DS, Upton TM, Ladha MH, Neumann E, Zalvide J, Bernhards R, DeCaprio JA & Ewen ME (1997) "Ras signaling linked to the cell-cycle machinery by the retinoblastoma protein" . Nature 382: 88-90

Petersen I, Langreck H, Wolf G, Schwendel A, Psille R, Vogt P, Reichel MB, Ried T & Dietel M (1997) "Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. " Br J Cancer 75: 79-86

Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC & Mason DY (1993) "bcl-2 protein in non-small cell lung carcinoma" . New Engl J Med 329: 690-694

Potts BC, Smith J, Akke M, Macke TJ, Okazaki K, Hidaka H, Case DA & Chazin WJ (1995) "The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins." Nat Struct Biol 2: 790-796

Rabbitts P, Bergh J, Douglas J, Collins F & Waters J (1990) "A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma." Genes Chromosomes Cancer 2: 231-238

Rachwal WJ, Bongiorno PF, Orringer MB, Whyte RI, Ethier SP & Beer DG (1995) "Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas" . Br J Cancer 72: 56-64

Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD & Bigner SH (1995) "Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25" . Oncogene 10: 2243-2246

Ray ME, Su YA, Meltzer PS & Trent JM (1996) "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma." Oncogene 12: 2527-2533

Ray ME, Wistow G, Su YA, Meltzer PS & Trent JM (1997) "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in humnan malignant melanoma. " Proc Natl Acad Sci USA 94: 3229-3234

Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes EC, Piantadosi S, Cordon-Cardo C & Slamon DJ (1993) "Inactivation of the retinoblastoma susceptibility gene in non-small cell lung cancer." Oncogene 8: 1913-1919

Richardson GE & Johnson BE (1993) "The biology of lung cancer." Semin Oncol 20: 105-127

Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schrock E, du Manoir S & Cremer T (1994) "Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization" . Cancer Res 54: 1801-1806

Robbins KC, Summaria L, Hsieh B & Shah RJ (1967) "The peptide chains of human plasmin, mechanism of activation system of human plasminogen to plasmin" . J Biol Chem 242: 2333-2342

Rodenhuis S & Slebos RJ (1992") Clinical significance of ras oncogene activation in human lung cancer. " Cancer Res 52: 2665s-2669s

Rosell R, Li S, Skacel Z, Mate JL, Maestre J, Canela M, Tolosa E, Armengol P, Barnadas A & Ariza A (1993) "Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients" . Oncogene 8: 2407-2412

Roth K, Wolf G, Dietel M & Petersen I (1997) "Image analysis for Comparative Genomic Hybridization (CGH) based on a karyotyping program for Windows" . Analytical and Quantitative Cytology and Histology 19: 461-474

Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, McIntosh J, Kurie J & Dmitrovsky E (1993") Differential expression of the epidermal growth factor receptor and ist ligands in primary non-small cell lung cancers and adjacent benign lung. " Cancer Res 53: 2379-2385

Rusin MR, Okamoto A, Chorazy M, Czyzewski K, Harasim J, Spillare EA, Hagiwara K, Hussain SP, Xiong Y, Demetrick DJ & Harris CC (1996) "Intragenic mutations of the p16INK4, p15INK4B and p18 genes in primary non-small-cell lung cancers" . Int J Cancer 65: 734-739

Sager R (1997) "Expression genetics in cancer: shifting the focus from DNA to RNA" . Proc Natl Acad Sci USA 94: 952-955

Sato S, Nakamura Y & Tsuchiya E (1994) "Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung" . Cancer Res 54: 5652-5655

Schena M, Shalon D, Davis RW & Brown PO (1995) "Quantitative monitoring of gene expression patterns with a complementary DNA microarray" . Science 270: 467-4670

Schneider PM, Hung MC, Chiocca SM, Manning J, Zhao X, Fang K & Roth JA (1989) "Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer" . Cancer Res 49: 4968-4971

Schwartz AG, Yang P & Swanson GM (1996) "Familial risk of lung cancer among nonsmokers and their relatives." Am J Epidemiol 144: 554-562

Schwendel A, Langreck H, Reichel M, Schröck E, Ried T, Dietel M & Petersen I (1997) "Primary small cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations" . Int J Cancer (Pred Oncol) 74: 86-93

Sekido Y, Fong KM & Minna JD (1998) "Progress in understanding the molecular pathogenesis of human lung cancer." Biochimica et Biophysica Acta 1378: F21-F59

Sekido Y, Takahashi T, Ueda R, Takahashi M, Suzuki H, Nishida K & Tsukamoto T (1993) "Recombinant human stemm cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene" . Cancer Res 53: 1709-1714

Sellers TA, Bailay-Wilson JE, Elston RC, Wilson AF, Elston GZ, Ooi WL & Rothschild H (1990) "Evidence for mendelian inheritance in the pathogenesis of lung cancer. " J Natl Cancer Inst 82: 1272-1279

Sen S, Zhou H & White RA (1997) "A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. " Oncogene 14: 2195-2200

Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ & Rollins BJ (1995) "Reciprocal RB inactivation and p16INK4 expression in primary lung cancers and cell lines" . Cancer Res 55: 505-509

Shaw GL, Falk RT, Deslauriers J, Frame JN, Nesbitt JC, Pass HI, Issaq HJ, Hoover RN & Tucker MA (1995) "Debrisoquine metabolism and lung cancer risk" . Cancer Epidemiol Biomarkers Prev 4: 41-48

Shi D, He G, Cao S, Pan W, Zhang HZ, Yu D & Hung MC (1992) "Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancer." Mol Carcinogen 5: 213-218

Shields PG & Harris CC (1993) "Genetic predisposition to cancer" , In: Roth JA, Cox JD and Hong WK (eds) Lung Cancer . Boston, Blackwell, p.3

Shimizu T & Sekiya T (1995) "Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers" . Int J Cancer 63: 616-620

Shiseki M, Kohno T, Adachi J, Okazaki T, Otsuka T, Mizoguchi H, Noguchi M, Hirohashi S & Yokota J (1996) "Comparative allelotype of early and advanced stage non-small cell lung carcinomas" . Genes Chromosomes Cancer 17:71-77

Siegfried JM, Weissfeld LA, Singh-Kaw P, Weyant RJ, Testa JR & Landreneau RJ (1997) "Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer." Cancer Res 75: 433-439

Slebos RJC, Evers SG, Wagenaar SS & Rodenhuis S (1989) "Cellular protooncogenes are infrequently amplified in untreated non-small cell lung cancer (NSCLC)." Br J Cancer 59: 76-80

Smith AL, Hung J, Walker L, Rogers TE, Vuitch F, Lee E & Gazdar AF (1996) "Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients" . Br J Cancer 73: 203-209

Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K & Croce CM (1996) "The FHIT gene 3p14.2 is abnormal in lung cancer." Cell 85: 17-26

Speaks SL, Sanger WG, Masih AS, Harrington DS, Hess M & Armitage JO (1992) "Recurrent abnormalities of chromosome bands 10q23-25 in non-Hodgkin's lymphoma" . Genes Chromosomes Cancer 5: 239-243

Steck PA, Ligon AH, Cheong P, Yung WK & Pershouse MA (1995) "Two tumor suppressive loci on chromosome 10 involved in human glioblastomas." Genes Chromosomes Cancer 12: 255-261

Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH & Tavtigian SV (1997) "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers." Nat Genet 15: 356-362

Sugio K, Kishimoto Y, Virmani AK, Hung JY & Gazdar AF (1994) K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. Cancer Res 54: 5811-5815

Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM & Rabbitts P (1992) "p53 and chromosome 3 abnormalities, characteristic of malignant lung tumors, are detectable in preinvasive lesions of the bronchus" . Oncogene 7: 1989-1997

Szallasi Z (1998) "Gene expression patterns and cancer" . Nat Biotechnology 16: 1292-1293

Tamura K, Zhang X, Murakami Y, Hirohashi S, Xu HJ, Hu SX, Benedict WF & Sekiya T (1997) "Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer" . Int J Cancer 74: 45-49

Tanaka H, Fujii Y, Hirabayashi H, Miyoshi S, Sakaguchi M, Yoon HE & Matsuda H (1998) "Disruption of the RB pathway and cell-proloferative activity in non-small-cell lung cancers." Int J Cancer 79: 111-115

Tanner MM, Tirkkonen M, Kallionemi A, Collins C, Stokke T, Karhu R, Kowbel D, Shadravan F, Hintz M, Kuo WL, Waldman FM, Isola JJ, Gray GW & Kallionemi OP (1994) "Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes." Cancer Res 54: 4257-4260

Tateishi M, Ishida T, Mitsudomi T, Kaneko S & Sugimachi K (1990) "Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the lung" . Cancer Res 50: 7077-7080

Thompson MA & Ziff EB (1989) "Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein" . Neuron 2: 1043-1053

Todd S, Franklin WA, Varella-Garcia M, Kennedy T, Hilliker Jr C, Hahner L, Anderson M, Wiest JS, Drabkin HA & Gemmill RM (1997) "Homozygous deletions of human chromosome 3p in lung tumors. " Cancer Res 57: 1344-1352

To-Figueras J, Gene M, Gomez J, Galan C, Firvida J, Fuentes M, Rodamilans M, Huguet E, Estape J & Corbella J (1996") Glutathione M1 and codon 72p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility." Cancer Epidemiol Biomarkers Prev 5: 337-342

Tonini GP, Casalaro A, Cara A & Di Martino D (1991) "Inducible expression of calcyclin, a gene with strong homology to S-100 protein, during neuroblastoma cell differentiation and its prevalent expression in Schwann-like cell lines" . Cancer Res 51: 1733-1737

Urtreger A, Porro F, Puricelli L, Werbajh S, Baralle FE, Bal de Kier Joffe E, Kornblihtt AR & Muro AF (1998) "Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis" . Int J Cancer 78: 233-241

van Groningen JJ, Weterman MA, Swart GW & Bloemers HP (1995) "Functional analysis of the human calcyclin gene promoter in a panel of human melanoma cell lines." Biochem Biophys Res Commun 213: 1122-1131

Velculescu VE, Zhang L, Vogelstein B & Kinzler KW (1995) "Serial analysis of gene expression. " Science 270: 484-487

Viallet J & Sausville EA (1996) "Involvement of signal transduction pathways in lung cancer biology. " J Cell Biochem Suppl 24: 228-236

Washimi O, Nagatake M, Osada H, Ueda H, Koshikawa T, Seki T, Takahashi T & Takahashi T (1995) "In vivo occurence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers" . Cancer Res 55: 514-517

Weiner DB, Nordberg J, Robinson R, Nowell PC, Gazdar A, Greene MI, Williams WV, Cohen JA & Kern JA (1990) "Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung" . Cancer Res 50: 421-425

Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Weissman BE & Stanbridge EJ (1994) "Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity." Oncogene 9: 255-262

Werbajh SE, Urtreger AJ, Puricelli LI, de Lustig ES, Bal de Kier Joffe E & Kornblihtt AR (1998) "Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells." FEBS Lett 440: 277-281

Weterman MA, van Muijen GN, Bloemers HP & Ruiter DJ (1993) "Expression of calcyclin in human melanocytic lesions. " Cancer Res 53: 6061-6066

Williams DE, Pairolero PC, Davis C, Bernatz PE, Payne WS, Taylor WF, Uhenhopp MA & Fontana RS (1981) "Survival of patients surgically treated for stage I lung cancer." J Thoracic Cardiovasc Surg 82: 70-76

Xiang YY, Wang DY, Tanaka M, Suzuki M, Kiyokawa E, Igarashi H, Naito Y, Shen Q & Sugimura H (1997) "Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa." Int J Cancer 74: 1-6

Xu HJ, Hu SX, Cagle PT, Moore GE & Benedict WF (1991) "Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas." Cancer Res 51: 2735-2739

Xu HJ, Quinlan DC, Davidson AG, Hu SX, Summers CL, Li J & Benedict WF (1994) "Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma" . J Natl Cancer Inst 86: 695-699

Yoshino H, Endo Y, Watanabe Y & Sasaki T (1998) "Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis" . Br J Cancer 78: 833-839

Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR & Sen S (1998) "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation." Nat Genet 20: 189-193


[Titelseite] [1] [2] [3] [4] [5] [6] [Abkürzungsverzeichnis] [Bibliographie] [Danksagung] [Selbständigkeitserklärung] [Anhang]

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.

DiDi DTD Version 1.1
a subset from ETD-ML Version 1.1
Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML - Version erstellt am:
Wed Nov 3 16:22:28 1999