Molekulare Analyse der Nogo Expression und der Myelinisierung  im Hippocampus während der Entwicklung und nach LäsionSusan Meier122.112.1.12611#561342.1.2562.2782.333.1910113.23.2.1123.2.244.113144.24.3154.44.5164.64.7174.84.918192021345#1864.10224.114.124.132355.15.1.123586#469245.1.2551#479255.1.3585#266265.1.4461#746275.1.5585#236285.25.2.1383#691295.2.2555#698305.2.331536#39832548#4163334506#7453536524#380375.2.4520#417385.2.5455#2423966.1396.1.16.1.2406.1.3416.26.2.1426.2.2436.2.34445585#68146AbkürzungsverzeichnisLiteraturverzeichnisDanksagungLebenslaufEidesstattliche ErklärungdeInhaltsverzeichnisHilfe Literaturverzeichnis Acevedo, L., Yu, J., Erdjument– Bromage, H., Miao, R.Q., Kim, J.E., Fulton, D., Tempst, P., Strittmatter, S.M., Sessa, W.C. (2004) A new role for Nogo as a regulator of vascular remodeling. Nature Medicine. 10 (4), 382-8. Alcantara, S., Ruiz, M., De Castro, F., Soriano, E., Sotelo, C. (2000) Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development. 127, 1359-1372. Amaral, D.G. (1978) A Golgi study of cell types in the hilar region of the hippocampus in the rat. J.Comp Neurol. 182: 851-914. Amaral, D.G., Witter M.P., (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience. 31(3), 571-91. Baka, I. D., Ninkina, N. N., Pinon, L. G., Adu, J., Davies, A. M., Georgiev, G.-P., Buchman, V. L. (1996) Intracellular compartmentalization of two differentially spliced s-rex/NSP mRNAs in neurons. Mol Cell Neurosci. 7, 289-303 Bayer, S.A., Altman J. (1987) Directions in neurogenetic gradients and patterns of anatomical connections in the telencephalon. Progress in Neurobiology. 29, 57-106. Bayer, S. A., Altman, J. (1990) Development of layer I and the subplate in the rat neocortex. Exp.Neurol. 107, 48-62 Bechmann, I. and Nitsch. R. (1997) Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: a light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia; 20: 145-154. Bendotti, C., Pende, M. and Samanin, R. (1994) Expression of GAP-43 in the granule cells of rat hippocampus after seizure-induced sprouting of mossy fibres: in situ hybridization and immunocytochemical studies. Eur.J.Neurosci.; 6: 509-515. Bendotti, C., Baldessari, S., Pende, M., Southgate, T., Guglielmetti, F., Samanin, R. (1997) Relationship between GAP-43 expression in the dentate gyrus and synaptic reorganization of hippocampal mossy fibres in rats treated with kainic acid. Eur J Neurosci. 9, 93-101. Berger, T. and Frotscher, M. (1994) Distribution and morphological characteristics of oligodendrocytes in the rat hippocampus in situ and in vitro: an immunocytochemical study with the monoclonal Rip antibody. J.Neurocytol.; 23: 61-74. Blackstad, T.W. (1956) Commissural connections of the hippocampal region in the rat, with specific reference to their mode of termination. J Comp Neurol. 105: 417-537. Bovolenta, P., Fernaud-Espinosa, I., Mendez-Otero, R., Nieto, S. (1997) Neurite outgrowth inhibitor of gliotic brain tissue. Mode of action and cellular localization, studied with specific monoclonal antibodies. Eur.J.Neurosci. 9, 977-989 Bregman, B. S., Kunkel-Bagden, E., Schnell, L., Dai, H. N., Gao, D., and Schwab, M. E. (1995) Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498-501 Brauer, A. U., Savaskan, N. E., Kole, M. H., Plaschke, M., Monteggia, L. M., Nestler, E. J., Simburger, E., Deisz, R. A., Ninnemann, O., and Nitsch, R. (2001) Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J. 15, 2689-2701 Brittis, P. A., Flanagan, J. G. (2001) Nogo domains and a Nogo receptor: implications for axon regeneration. Neuron 30, 11-14 Brosamle, C., Huber, A. B., Fiedler, M., Skerra, A., and Schwab, M. E. (2000) Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment. J.Neurosci. 20, 8061-8068 Buffo, A., Zagrebelsky, M., Huber, A. B., Skerra, A., Schwab, M. E., Strata, P., and Rossi, F. (2000) Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. J.Neurosci. 20, 2275-2286 Burwell, R.D., Witter, M.P., Amaral, D.G. (1995) Perirhinal and postrhinal cortices of the rat: a review of the neuroanatomical literature and comparison with findings from the monkey brain. Hippocampus. 5(5), 390-408. Busciglio, J., Ferreira, A., Steward, O., Caceres, A. (1987) An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain Res. 419(1-2), 244-52. Cabalka, L.M., Hyman, B.T., Goodlett, C.R., Ritchie, T.C., Van Hoesen, G.W. (1992) Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in the Alzheimer´s disease and in rats after entorhinal lesions. Neurobiol Aging. 13(2), 283-91 Cadelli, D. S., Bandtlow, C. E., Schwab, M. E. (1992) Oligodendrocyte- and myelin-associated inhibitors of neurite outgrowth: their involvement in the lack of CNS regeneration. Exp.Neurol. 115, 189-192 Cammer W. and Norton W. T. (1976) Disc gel electrophoresis of myelin proteins: new observations on development of the intermediate proteins (DM-20). Brain Res 109, 643-648. Campagnoni A.T and Macklin W.B. (1988) Cellular and molecular aspects of myelin protein gene expression. Mol Neurobiol. 1988; 2: 41-89. Caroni, P., and Schwab, M. E. (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1, 85-96 Caroni, P., and Schwab, M. E. (1988) Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J.Cell Biol 106, 1281-1288 Chapman A.G, Westerberg E, Premachandra M and Meldrum B.S. (1984) Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. J.Neurochem. 1984; 43: 62-70. Chen, M. S., Huber, A. B., van der Haar, M. E., Frank, M., Schnell, L., Spillmann, A. A., Christ, F., and Schwab, M. E. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439 Clusmann, H., Nitsch, R. and Heinemann, U.. (1994) Long lasting functional alterations in the rat dentate gyrus following entorhinal cortex lesion: a current source density analysis. Neuroscience; 61: 805-815. Coetzee, T., Fujita, N., Dupree, J., et al. (1996) Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell; 86: 209-219. Cole A.J., Abu-Shakra S, Saffen D.W., Baraban J.M., Worley P.F. (1990) Rapid rise in transcription factor mRNAs in rat brain after electroshock-induced seizures. J Neurochem. 55(6):1920-7. Cotman C, Gentry C and Steward O. (1977) Synaptic replacement in the dentate gyrus after unilateral entorhinal lesion: electron microscopic analysis of the extent of replacement of synapses by the remaining entorhinal cortex. J.Neurocytol. 6: 455-464. Cotman, C. W., Nieto-Sampedro, M. (1985) Progress in facilitating the recovery of function after central nervous system trauma. Ann.N.Y.Acad.Sci. 457, 83-104 Cotman, C.W., Geddes, J.W., Kahle, J.S. (1990) Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? Prog Brain Res. 83, 427-34 Dasheiff, R.M., McNamara, J.O., (1982) Electrolytic entorhinal lesions cause seizures. Brain Res. 231(2), 444-50 David, S., and Aguayo, A. J. (1981) Axonal elongation into peripheral nervous system „bridges“ after central nervous system injury in adult rats. Science 214, 913-933 Deller, T., Frotscher, M., Nitsch, R. (1995) Morphological evidence for the sprouting of inhibitory commissural fibers in response to the lesion of the excitatory entorhinal input to the rat dentate gyrus. J.Neurosci. 15, 6868-6878 Deller, T., Frotscher, M., Nitsch, R. (1996) Sprouting of crossed entorhinodentate fibers after a unilateral entorhinal lesion: anterograde tracing of fiber reorganization with Phaseolus vulgaris-leucoagglutinin (PHAL). J Comp Neurol. 365(1), 42-55. Deller, T., and Frotscher, M. (1997) Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion. Prog.Neurobiol. 53, 687-727 Demerens, C., Stankoff, B., Logak, M., et al. (1996) Induction of myelination in the central nervous system by electrical activity. Proc.Natl.Acad.Sci U.S.A; 93: 9887-9892. Dobkin, J. and Marton, M. (1970) A new procedure for the measurement of acid-soluble glutamine of tissue with particular reference to the brain. J.Neurochem.; 17: 231-235. Dou, C. L., and Levine, J. M. (1994) Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan. J.Neurosci. 14, 7616-7628 Duden (2004) Die deutsche Rechtschreibung. 23. Auflage Eyüpoglu, I., Bachmann, I., Nitsch, R. (2003) Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus.FASEB J.;17(9) :1110-1. Epub 2003 Apr 08. Eyupoglu, I.Y., Savaskan, N.E., Brauer, A.U., Nitsch, R., Heimrich, B. (2003) Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res Brain Res Protoc. Mar;11(1), 1-8. Forster, E., Zhao, S., Frotscher, M. (2001) Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus. Development 128, 3029-3039 Fournier, A. E., GrandPre, T., and Strittmatter, S. M. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341-346 Fournier, A.E., GrandPre, T., Gould, G., Wang, X., Strittmatter, S.M., (2002) Nogo and the Nogo-66 receptor. Prog Brain Res. 137: 361-9 Fricke, R. and Cowan, W.M. (1977) An autoradiographic study of the development of the entorhinal and commissural afferents to the dentate gyrus of the rat. J.Comp Neurol. 173: 231-250. Frotscher, M. and Leranth, C. (1985) Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study. J.Comp Neurol.; 239: 237-246. Frotscher, M. (1991) Target cell specificity of synaptic connections in the hippocampus. Hippocampus 1991; 1: 123-130. Frotscher, M., and Heimrich, B. (1993) Formation of layer-specific fiber projections to the hippocampus in vitro. Proc.Natl.Acad.Sci.U.S.A 90, 10400-10403 Frotscher, M., Heimrich, B., and Deller, T. (1997) Sprouting in the hippocampus is layer-specific. Trends Neurosci. 20, 218-223 Gallyas, F. (1979) Silver staining of myelin by means of physical development. Neurol Res 1, 203-209. Gall, C., Rose, G., Lynch, G. (1979) Proliferative and migratory activity of glial cells in the partially deafferented hippocampus. J Comp Neurol.;183, 539-549. Gao, P. P., Yue, Y., Cerretti, D. P., Dreyfus, C., Zhou, R. (1999) Ephrin-dependent growth and pruning of hippocampal axons. Proc.Natl.Acad.Sci.U.S.A 96, 4073-4077 Grady, M.S., Jane, J.A., Steward, O. (1989) Synaptic reorganization within the human central nervous system following injury. J Neurosurg. 71(4), 534-7. GrandPre, T., Nakamura, F., Vartanian, T., and Strittmatter, S. M . (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444 GrandPre, T., and Strittmatter, S. M. (2001) Nogo: a molecular determinant of axonal growth and regeneration. Neuroscientist. 7, 377-386 GrandPre, T., and Strittmatter, S. M. (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417, 547-551 Haas, C. A., Rauch, U., Thon, N., Merten, T., Deller, T. (1999) Entorhinal cortex lesion in adult rats induces the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes. J.Neurosci. 19, 9953-9963 Henderson, Z., Morris, N.P., Grimwood, P., Fiddler, G., Yang, H.W, and Appenteng, K. (2001) Morphology of local axon collaterals of electrophysiologically characterised neurons in the rat medial septal/ diagonal band complex. J.Comp Neurol.; 430: 410-432. Hens, J., Nuydens, R., Geerts, H., Senden, N. H., Van de Ven, W. J., Roebroek, A. J., van de Velde, H. J., Ramaekers, F. C., Broers, J. L. (1998) Neuronal differentiation is accompanied by NSP-C expression. Cell Tissue Res. 292, 229-237 Horner, P. J., and Gage, F. H. (2000) Regenerating the damaged central nervous system. Nature 407, 963-970 Holder, N., Klein, R. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development. 126, 2033-2044. Hu, W.H, Hausmann, O.N., Yan, M.S, Walters, W.M., Wong, P.K., Bethea, J.R. (2002) Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). J Neurochem. 81: 36-45. Huber, A. B., Weinmann, O., Brosamle, C., Oertle, T., Schwab, M.E. (2002) Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J Neurosci. 22, 3553-3567 Hyman, B. T., Van Horsen, G.W., Damasio, A.R., Barnes, C.L. (1984) Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 225: 1168-1170. Jensen, M.B., Gonzalez, B., Castellano, B., Zimmer, J. (1994) Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions. Exp Brain Res. 98(2), 245-60. Jensen, J.B. and Mork, A. (1997) Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments. Eur.Neuropsychopharmacol.; 7: 173-179. Jensen, M.B., Poulsen, F.R. and Finsen, B. (2000) Axonal sprouting regulates myelin basic protein gene expression in denervated mouse hippocampus. Int.J.Dev.Neurosci.; 18: 221-235. Josephson, A., Widenfalk, J., Widmer H. W., Olson L., and Spenger (2001) NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury. Exp Neurol. 169 (2), 319- 328 Josephson, A., Trifunovski, A., Scheele, C., Widenfalk, J., Wahlestedt, C., Brene, S., Olson L., and Spenger (2003) Activity-induced and developmental downregulation of Nogo receptor. Cell Tissue Res 311: 333-342. Kapfhammer J.P. and Schwab M.E. (1992) Modulators of neuronal migration and neurite growth. Curr.Opin.Cell Biol; 4: 863-868. Kawaja M.D. and Gage F.H. (1991) Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron; 7: 1019-1030. Kawaja M.D. and Gage F.H. (1991) Nerve growth factor receptor immunoreactivity in the rat septohippocampal pathway: a light and electron microscope investigation. J.Comp Neurol. 307: 517-529. Kelley, M.S., Steward, O., (1997) Injury-induced physiological events that may modulate gene expression in neurons and glia. Rev Neurosci. 147-77. Kim, J.E., Shuxin, L., GrandPre, T., Qiu, D., Strittmatter, S.M (2003) Axon Regeneration in Young Adult Mice Lacking Nogo-A/B. Neuron, 38, 187- 199 Kovac, A., Kwidzinski, E., Heimrich B., Nitsch, R. (2001) Transneuronal apoptosis following entorhinal cortex lesion in the dentate gyrus. Soc Neuroscie Abstract 27: 253. Kovac A.C., Kwidzinski, E., Heimrich, B., Bittigau, P., Deller, T., Nitsch, R., Bechmann, I. (2004) Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons. Brain Pathology, 14(3): 249-57 Kugler, P., Schleicher, A., Zilles, K. and Horvath, E. (1993) Acetylcholinesterase activity and post-lesional plasticity in the hippocampus of young and aged rats. Neuroscience; 55: 91-103. Kluver, H., and Barrera, E. (1953) Method for combined staining of cells and fibers in the nervous system. J Neuropathol Exp Neurol 12, 400-403 Kottis V., Thibault P., Mikol D., Xiao Z. C., Zhang R., Derham P., Braun P. E. (2002) Oligodendrocytes-myelin glycoprotein (Omgp) is an inhibitor of neurite outgrowth. J Neurochem 82, 1566-1569 Lee, K.S., Stanford E.J., Cotman, C.W., Lynch G.S. (1977) Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat. Exp Brain Res. 29(3-4), 475-85. Li, S., Kim, J.E., Budel, S., Hampton, T.G., Strittmatter, S.M. (2005) Transgenic inhibition of Nogo-66-receptor function allows axonal sprouting ans improved locomotion after spinal injury. Mol Cell Neurosci. 29(1):26-39. Li M., Shibata A., Li C., Braun P. E., McKerracher L., Roder J., Kater S. B., and David S. (1996) Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J Neurosci Res 46, 404-414. Linke, R., Pabst, T., Frotscher, M., (1995) Development of the hippocamposeptal projection in the rat. J Comp Neurol. 351(4), 602-16. Liu, B.P., Fournier, A., GrandPre, T., Strittmatter SM. (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science online Jun 27. Lynch, G., Gall, C., Rose, G., Cotman, C. (1976) Changes in the distribution of the dentate gyrus associational system following unilateral or bilateral entorhinal lesions in the adult rat. Brain Res. 110(1), 57-71. Masuhr K. F.; Neumann M. (1998) Neurologie. Hippokrates Matthews, D.A., Cotman, C., Lynch, G., (1976), I An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration. Brain Res. 115, 1-21. Matthews, D. A., Cotman, C., Lynch, G. (1976), II An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res. 115, 23-41. Matute, C., Alberdi, E., Domercq, M., Perez-Cerda, F., Perez-Samartin, A. and Sanchez-Gomez, M.V. (2001) The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci.; 24: 224-230. McKerracher, L., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., and Braun, P. E. (1994) Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13, 805-811 Meier C. (1976) Some observations on early myelination in the human spinal cord. Light and electron microscope study. Brain Res 104, 21-32. Meier, S., Brauer, A. U., Heimrich, B., Schwab, M. E., Nitsch, R., and Savaskan, N. E. (2003) Molecular Analysis of Nogo expression in the hippocampus during development and following lesion and seizure. FASEB J. Published online April 8, 2003 Meier, S., Brauer, A. U., Heimrich, B., Nitsch, R., and Savaskan, N. E. (2004 ) Myelination in the hippocampus during development and following lesion. Cell Mol Life Sci Mesulam M. M., Asuncion Moran M. (1987) Cholinesterases within neurofibtillary tangles related to age and Alzheimer’s disease. Ann Neurol 22, 223-228. Mesulam M.M., Mufson E.J. and Rogers J. (1987) Age-related shrinkage of cortically projecting cholinergic neurons: a selective effect. Ann.Neurol.; 22: 31-36. Morell, P., and Ousley, A.H. (1994) Metabolic turnover of myelin glycerophospholipids. Neurochem.Res. 19: 967-974. Morell, P., Barrett, C.V., Mason, J.L., et al. (1998) Gene expression in brain during cuprizone-induced demyelination and remyelination. Mol Cell Neurosci.; 12: 220-227. Morell, P., Quarles, R. H. , and Norton, W. T. (1994) Myelin formation, structure, and biochemistry. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. G. J. Siegel, B.W. Agranoff, R.W. Albers, and P. B. Molinoff, eds. (New York: Raven Press), pp. 117-143 Mukhopadhyay, G., Doherty, P., Walsh. F. S., Crocker, P. R., and Filbin, M. T. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13, 757-767 Nafstad P.H. (1967) An electron microscope study on the termination of the perforant path fibres in the hippocampus and the fascia dentata. Z.Zellforsch.Mikrosk.Anat.; 76: 532-542. Nie, D.Y., Zhou, H.Z., Ang, T.B., Teng, F.Y.H., Xu., G., Xiang, T., Wang, C., Zeng, L., Takeda, Y., Xu, T, Ng, Y, Faivre-Sarrailh, C., Popko, B., Ling, E, Schachner, M., Watanabe, K, Pallen, C.J., Tang, B.L. Xio, Z. (2003) Nogo-A at CNs paranodes is ligand of Caspr: possible regulation of K+ channal localization. EMBO. 22, 5666-5678 Niederost, B. P., Zimmermann, D. R., Schwab, M. E., and Bandtlow, C. E. (1999) Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans. J.Neurosci. 19, 8979-8989 Nitsch, R., Frotscher, M. (1992) Reduction of posttraumatic transneuronal "early gene" activation and dendritic atrophy by the N-methyl-D-aspartate receptor antagonist MK-801. Proc Natl Acad Sci U S A. 89(11), 5197-200. O´Connor, L.T., Goetz, B.D., Couve, E., Song, J., Duncan, I.D. (2000) Intracellular distribution of myelin protein gene products is altered in ologodendrocytes of the taiep rat. Mol Cell Neurosci 16 (4): 396-407 Oertel, D., Bal, R., Gardner, S.M., Smith, P.H., Joris, P.X., (2000) Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus. Proc Natl Acad Sci U S A. 97(22), 11773-9. Parnavelas, J.G., Lynch, G., Brecha, N., Cotman, C. W., Globus, A. (1974) Spine loss and regrowth in hippocampus following deafferentation. Nature. 248 (443), 71-3. Paxinos, G., Watson, C., Pennisi, M., and Topple, A. (1985) Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J Neurosci Methods. 13, 139-143 Oertel, T., Bandtlow, C.E., Schwab, M.E. (2000) Characterization of the gene structure and the inhibitory regions of Nogo/RTN4. Soc Neuroscie Abstract 26: 573. Phillips, L.L., Belardo, E.T. (1994) Increase of c-fos and ras oncoproteins in the denervated neuropil of the rat dentate gyrus. Neuroscience. 58(3), 503-14. Pitt D, Werner P and Raine C.S. (2000) Glutamate excitotoxicity in a model of multiple sclerosis. Nat.Med. 6: 67-70. Prinjha, R., Moore, S. E., Vinson, M., Blake, S., Morrow, R., Christie, G., Michalovich, D., Simmons, D. L., and Walsh, F. S. (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383-384 Pschyrembel. (1994) Klinisches Wörterbuch. deGruyter, 257. Auflage Raineteau, O., Schwab, M. E. (2001) Plasticity of motor systems after incomplete spinal cord injury. Nat.Rev.Neurosci. 2, 263-273 Raisman, G., (1969) Neuronal plasticity in the septal nuclei of the adult rat. Brain Res. 25-48. Ramirez, J.J. (2001) The role of axonal sprouting in functional reorganization after CNS injury: lessons from the hippocampal formation. Restor Neurol Neurosci.;19(3-4), 237-62 Ribak C.E., Seress L and Amaral D.G. (1985) The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus. J.Neurocytol.; 14: 835-857. Richardson P.M., McGuinness U.M. and Aguayo A.J. (1980) Axons from CNS neurons regenerate into PNS grafts. Nature 284: 264-265. Rust, R.-S. J., Carter, J. G., Martin, D., Nerbonne, J. M., Lampe, P. A., Pusateri, M. E., Lowry, O. H. (1991) Enzyme levels in cultured astrocytes, oligodendrocytes and Schwann cells, and neurons from the cerebral cortex and superior cervical ganglia of the rat. Neurochem.Res. 16, 991-999 Savaskan, N. E., Plaschke, M., Ninnemann, O., Spillmann, A. A., Schwab, M. E., Nitsch, R., Skutella, T. (1999) Myelin does not influence the choice behaviour of entorhinal axons but strongly inhibits their outgrowth length in vitro. Eur.J.Neurosci. 11, 316-326 Savaskan N.E., Eyupoglu I.Y., Brauer A.U., et al. (2000) I Entorhinal cortex lesion studied with the novel dye fluoro-jade. Brain Res. 864: 44-51. Savaskan, N. E., Skutella, T., Brauer, A. U., Plaschke, M., Ninnemann, O., Nitsch, R. (2000) II Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion. Eur.J.Neurosci. 12, 1024-1032 Savaskan, N. E., and Nitsch, R. (2001) Molecules involved in reactive sprouting in the hippocampus. Rev.Neurosci. 12, 195-215 Savaskan, N. E., Alvarez-Bolado, G., Glumm, R., Nitsch, R., Skutella T., and Heimrich, B. (2002) Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutants. J Neurochem 83, 1196-207 Savio, T. and Schwab, M.E. (1990) Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord. Proc.Natl.Acad.Sci.U.S.A 87: 4130-4133. Scheff, S.W., Cotman, C.W., (1977) Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting. Behav Biol. 21(2), 286-93. Schmued, L., Albertson, C., Slikker, W.J. (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751(1), 37-46. Schmued, L. and Slikker, W.J. (1999) Black-gold: a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sections. Brain Res. 837: 289-297. Schnell, L., and Schwab, M. E. (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272 Schnell, L., Schneider, R., Kolbeck, R., Barde, Y. A., Schwab, M. E. (1994) Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367, 170-173 Schwab, M. E., and Bartholdi, D. (1996) Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev. 76, 319-370 Scott B.W, Wojtowicz J.M. and Burnham W.M. (2000) Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures. Exp.Neurol.; 165: 231-236. Simonen, M., Pedersen, V., Weinmann, O., Schnell, L., Buss., Ledermann, B., Christ., F., Sansig., G., van der Putten, H., Schwab, ME. (2003) Systemic Deletion of the Myelin-Associated Outgrowth Inhibitor Nogo-A Improves Regenerativ and Plastic Responses after Spinal Cord Injury. Neuron. 38., 201-211 Skaper, S.D., Moore. S.E., Walsh FS. (2001) Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues. Prog Neurobiol. 65, 593-608 Skutella, T., Savaskan, N. E., Ninnemann, O., Nitsch, R. (1999) Target- and maturation-specific membrane-associated molecules determine the ingrowth of entorhinal fibers into the hippocampus. Dev.Biol 211, 277-292 Skutella, T., and Nitsch, R. (2001) New molecules for hippocampal development. Trends Neurosci. 24, 107-113 Smith P.M. and Blakemore W.F. (2000) Porcine neural progenitors require commitment to the oligodendrocyte lineage prior to transplantation in order to achieve significant remyelination of demyelinated lesions in the adult CNS. Eur.J.Neurosci. 12: 2414-2424. Smith R. (1992) The basic protein of CNS myelin: its structure and ligand binding. J Neurochem 59, 1589-1608. Snyder, D. C., Coltman, B. W., Muneoka, K., Ide, C. F. (1991) Mapping the early development of projections from the entorhinal cortex in the embryonic mouse using prenatal surgery techniques. J.Neurobiol. 22, 897-906 Stein, E., Savaskan, N. E., Ninnemann, O., Nitsch, R., Zhou, R., Skutella, T. (1999) A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. J.Neurosci. 19, 8885-8893 Steup, A., Ninnemann, O., Savaskan, N. E., Nitsch, R., Puschel, A. W., Skutella, T. (1999) Semaphorin D acts as a repulsive factor for entorhinal and hippocampal neurons. Eur.J.Neurosci. 11, 729-734 Steup, A., Lohrum, M., Hamscho, N., Savaskan, N. E., Ninnemann, O., Nitsch, R., Fujisawa, H., Puschel, A. W., Skutella, T. (2000) Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation. Mol Cell Neurosci. 15, 141-55. Steward, O. (1976) Reinnervation of dentate gyrus by homologous afferents following entorhinal cortical lesions in adult rats. Science. 194, 426-428 Steward, O., Loesche, J. (1977) Quantitative autoradiographic analysis of the time course of proliferation of contralateral entorhinal efferents in the dentate gyrus denervated by ipsilateral entorhinal lesions. Brain Res. 125(1), 11-21. Steward, O., Scoville, S.A., (1976) Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat. J Comp Neurol. 169(3), 347-70. Steward, O., Vinsant, S.L., Davis, L., (1988) The process of reinnervation in the dentate gyrus of adult rats: an ultrastructural study of changes in presynaptic terminals as a result of sprouting. J Comp Neurol. 267(2), 203-10. Steward, O., Kelley, M. S., Torre, E. R. (1993) The process of reinnervation in the dentate gyrus of adult rats: temporal relationship between changes in the levels of glial fibrillary acidic protein (GFAP) and GFAP mRNA in reactive astrocytes. Exp.Neurol. 124, 167-183 Steward, O., (1995) The process of reinnervation in the dentate gyrus of adult rats: gene expression by neurons during the period of lesion-induced growth. J Comp Neurol. 359(3), 391-411. Super, H., and Soriano, E. (1994) The organization of the embryonic and early postnatal murine hippocampus. II. Development of entorhinal, commissural, and septal connections studied with the lipophilic tracer DiI. J.Comp Neurol. 344, 101-120 Suzuki, M., Raisman, G. (1994) Multifocal pattern of postnatal development of the macroglial framework of the rat fimbria. Glia 12, 294-308 Tessier-Lavigne, M., and Goodman, C. S. (1996) The molecular biology of axon guidance. Science 274, 1123-1133 Tessier-Lavigne, M., Goodman, C. S. (2000) Perspectives: neurobiology. Regeneration in the Nogo zone. Science 287, 813-814 Thon, N., Haas, C.A., Rauch, U., Merten, T., Fassler, R., Frotscher, M., Deller, T. (2000) The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Eur J Neurosci. 12,2547-2558 Trapp B. D., Andrews S. B., Wong A., O'Connell M., and Griffin J. W. (1989) Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres. J Neurocytol 18, 47-60. de Vries H., de Jonge J.C., Schrage C., van der Haar M.E., Hoekstra D. (1997) Differential and cell development-dependent localization of myelin mRNAs in oligodendrocytes. J Neurosci Res. ar 1;47(5): 479-88. Van de Velde, H. J., Roebroek, A. J., Senden, N. H., Ramaekers, F.C., Van de Ven, W. J. (1994) NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum. J Cell Sci. 107, 2403-16. Wade J.V., Samson F.E., Nelson S.R. and Pazdernik T.L. (1987). Changes in extracellular amino acids during soman- and kainic acid-induced seizures. J.Neurochem. 49: 645-650. Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R., He, Z. (2002 ) I P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420: 74-8 Wang, K.C., Koprivica, V., Kim, J.A., Sivasankaran, R., Guo, Y., Neve, R.L., He, Z. (2002) II Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417:941-4. Wang, X., Chun, S.J., Treloar, H., Vartanian, T., Greer, C.A., Strittmatter, S.M., (2002) III Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci. 22, 5505-15 Ward, N. L., and Haag, T . (1999) BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo. Exp Neurol 162, 297- 310 Weibel, D., Cadelli, D., Schwab, M. E. (1994) Regeneration of lesioned rat optic nerve fibers is improved after neutralization of myelin-associated neurite growth inhibitors. Brain Res. 642, 259-266 Weigert C. (1884) Ausfuehrliche Beschreibung der in No. 2 dieser Zeitschrift erwaehnten neuen Faerbungsmethode für das Zentralenervensystem, Fortschritte der Medizin 2, 190-194 Witter, M. P., Groenewegen, H. J., Lopes-da-Silva, F. H., Lohman, A. H. (1989) Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog.Neurobiol. 33, 161-253 Woolf, C.J. (2003) No Nogo: Now Where to go?. Neuron, 38, 153-156 Wu, W., Wong, K., Chen, J., Jiang, Z., Dupuis, S., Wu, J. Y., Rao, Y. (1999) Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 400, 331-6 Zagrebelsky, M., Buffo, A., Skerra, A., Schwab, M. E., Strata, P., and Rossi, F. (1998) Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins. J.Neurosci. 18, 7912-7929 Z'Graggen, W. J., Metz, G. A., Kartje, G. L., Thallmair, M., Schwab, M. E. (1998) Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats. J.Neurosci. 18, 4744-4757