Meyer, Hellmuth-Alexander: Identifizierung und Charakterisierung evolutionär konservierter Komponenten des Protein-Translokationsapparates im Endoplasmatischen Retikulum



Andersson, H. and von Heijne, G. 1994 "Membrane protein topology: effects of delta mu H+ on the translocation of charged residues explain the 'positive inside' rule." EMBO J. 13, S.2267-2272

Baker, R. K. and Lively, M. O. 1987 "Purification and characterization of hen oviduct microsomal signal peptidase." Biochemistry 26, S.8561-8567

Beckmann, R. et al. 1997 "Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex." Science 278, S.2123-2126

Behrens, M. et al. 1991 "Mitochondrial inner membrane protease 1 of Saccharomyces cerevisiae shows sequence similarity to the Escherichia coli leader peptidase." Mol. Gen. Genet. 228, S.167-176

Birnboim, H. C. and Doly, J. 1979 "A rapid alkaline extraction procedure for screening recombinant plasmid DNA." Nucleic Acids Res. 24, S.1513-1523

Black, M. T. 1993 "Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad." J. Bacteriol. 175, S.4957-4961

Blobel, G. and Dobberstein, B. 1975 "Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane bound ribosomes of murine myeloms. II. Reconstitution of functional rough microsomes from heterologous components." J. Cell Biol. 67, S.835-862

Boeke, J. D. et al. 1987 "5-Fluroorotic acid as a selective agent in yeast molecular genetics." Methods Enzymol. 154, S.164-175

Böhni, P. C. et al. 1988 "SEC11 is required for signal peptide processing and yeast cell growth." J. Cell Biol. 106, S.1035-1042

Bullock, W. O. et al. 1987 "XL1-blue: a high effiency plasmid transforming rec A Escherichia coli strain with betagalactosidase selection." Biotechniques 5, S.376-378

Chirico, W. J. 1992 "Dissociation of complexes between 70 kDa stress proteins and presecretory proteins is facilitated by a cytosolic factor." Biochem. Biophys. Res. Commun. 189, S.1150-1156

Chirico, W. J. et al. 1988 "70K heat shock related proteins stimulate protein translocation into microsomes." Nature 332, S.805-810

Connolly, T. and Gilmore, R. 1989 "The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide." Cell 57, S.599-610

Crowley, K. S. et al. 1994 "Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore." Cell 78, S.461-471

Daimon, M. et al. 1997 "Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)." Biochem Biophys Res Commun. 230, S.100-104

Dalbey, R. E. and von Heijne, G. 1992 "Signal peptidases in prokaryotes and eukaryotes--a new protease family." Trends Biochem Sci. 17, S.474-478

Dalbey, R. E. et al. 1997 "The chemistry and enzymology of the type I signal peptidases." Protein Sci. 6, S.1129-1138


Deshaies, R. J. and Schekman, R. 1987 "A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum." J. Cell Biol. 105, S.633-645

Deshaies, R. J. and Schekman, R. 1989 "SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum." J. Cell Biol. 109, S.2653-2664

Deshaies, R. J. and Schekman, R. 1990 "Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery." Mol Cell Biol. 10, S.6024-6035

Deshaies, R. J. et al. 1988 "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides." Nature 332, S.800-805

Deshaies, R. J. et al. 1991 "Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex." Nature 349, S.806-808

Do, H. et al. 1996 "The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process." Cell 85, S.369-378

Dower, W. J. et al. 1988 "High efficiency transformation of E. coli by high voltage electroporation." Nucleic. Acids Res. 16, S.6127-6145

Dünnwald, M. et al. 1999 "Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum." Mol. Biol. Cell 10, S.329-344

Economou, A. and Wickner, W. 1994 "SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion." Cell 78, S.835-843

Economou, A. et al. 1995 "SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF." Cell 83, S.1171-1181

Esnault, Y. et al. 1993 "The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum." EMBO J. 12, S.4083-4093

Evans, E. A. et al. 1986 Proc. Natl. Acad. Sci. USA 83, S.581-585

Fang, H. and Green, N. 1994 "Nonlethal sec7" Mol. Biol. Cell 5, S.1-1

Fang, H. et al. 1996 "The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae." J. Biol. Chem. 271, S.16460-16465

Fang, H. et al. 1997 "In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum." J. Biol. Chem. 272, S.13152-13158

Feldheim, D. and Schekman, R. 1994 "Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex." J. Cell Biol. 126, S.935-943

Feldheim, D. et al. "(1992) Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation." Mol. Cell Biol. 12, S.3288-3296

Feldheim, D. et al. 1993 "Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum." Mol. Biol. Cell 4, S.931-939

Finke, K. et al. 1996 "A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae." EMBO J. 15, S.1482-1494


Gietz, R. D. and Schiestl, R., H. 1991 "Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier." Yeast 7, S.253-263

Gillece, P. et al. 2000 "The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane." Proc. Natl. Acad. Sci. U S A 97, S.4609-4614

Gilmore, R. et al. 1982 "Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor." J. Cell Biol. 95, S.470-477

Goffeau, A. et al. 1996 "Life with 6000 genes." Science 546, S.563-567

Görlich, D. and Rapoport, T. A. 1993 "Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane." Cell 75, S.615-630

Görlich, D. et al. 1992a "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation." Cell 71, S.489-503

Görlich, D. et al. 1992b Nature 357, S.47-52

Green, N. et al. 1992 "Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae." J. Cell Biol. 116, S.597-604

Guthrie, C. Fink, G. R. 1991 "Guide to Yeast Genetics and Molecular Biology." Methods in Enzymology.

Haeuptle, M. T. et al. 1989 "A tripartite structure of the signals that determine protein insertion into the endoplasmic reticulum membrane." J. Cell Biol. 108, S.1227-1236

Hamman, B. D. et al. 1998 "BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation." Cell 92, S.747-758

Hanein, D. et al. 1996 "Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation." Cell 87, S.721-732

Hartmann, E. et al. 1994 "Evolutionary conservation of components of the protein translocation complex." 367, S.654-657

Hegde, R. S. et al. 1998 "TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum." Cell 92, S.621-631

Heinrich, S.U. et al. 2000 "The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain." Cell 102, S.233-244

High, S. et al. 1991 "The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER." J. Cell Biol. 113, S.35-44

High, S. et al. 1993 "Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence." J. Biol. Chem. 268, S.26745-26751

Jackson, R. C. and Blobel G. 1980 "Post-translational processing of full-length presecretory proteins with canine pancreatic signal peptidase." Ann. N. Y. Acad. Sci. 343, S.391-404

Janknecht, R. et al. 1991 "Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus." Proc. Natl. Acad. Sci. USA 88, S.8972-8976

Johnston, M. and Davis, R. W. 1984 "Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae." Mol. Cell Biol. 4, S.1440-1448


Joly, J. C. and Wickner, W. 1993 "The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids." EMBO J. 12, S.255-263

Jungnickel, B. and Rapoport, T. A. 1995 "A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane." Cell 82, S.261-270

Kalies, K. U. and Hartmann, E. 1996 "Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex." J. Biol Chem. 271, S.3925-3929

Kalies, K. U. and Hartmann, E. 1998 "Protein translocation into the endoplasmic reticulum (ER)--two similar routes with different modes." Eur. J. Biochem. 254, S.1-5

Kalies, K. U. et al. 1994 "Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex." J. Cell Biol. 126, S.925-934

Kalies, K. U. et al. 1998 "The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation." J. Cell Biol 141, S.887-894

Kellaris, K. V. et al. 1991 "ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein." J. Cell Biol. 114, S.21-33

Klappa, P. et al. 1991 "A microsomal protein is involved in ATP-dependent transport of presecretory proteins into mammalian microsomes." EMBO J. 10, S.2795-2803

Klappa, P. et al. "(1994).The membrane proteins TRAMp and sec61 alpha p may be involved in post-translational transport of presecretory proteins into mammalian microsomes." FEBS Lett. 341, S.281-287

Knauer, R. and Lehle, L. "(1999) The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex." J. Biol. Chem. 274, S.17249-17256

Knight, B. C. and High, S. 1998 "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex." Biochem J. 331, S.161-167

Kornfeld, R. and Kornfeld, S. 1985 "Assembly of asparagine-linked oligosaccharides." Annu. Rev. Biochem. 54, S.631-664

Kurihara, T. and Silver, P. 1993 "Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus." Mol. Biol. Cell 4, S.919-930

Kurjan, J. and Herskowitz, I. 1982 "Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor." Cell 30, S.933-943

Kutay, U. et al. 1993 "A class of membrane proteins with a C-terminal anchor." Trends Cell Biol. 3, S.72-75

Kutay, U. et al. 1995 "Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane." EMBO J. 14, S.217-223

Kyte, J. and Doolittle, R. F. 1982 "A simple method for displaying the hydropathic character of a protein." J. Mol. Biol. 157, S.105-132

Laemmli, U. K. 1970 "Cleavage of structural proteins during the assembly of the head of bacteriophage T4." Nature 227, S.680-685

Lauber, J. et al. 1996 "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases." EMBO J. 15, S.4001-4015


Lingappa, V. R. et al. 1984 "Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes." Proc. Natl. Acad. Sci. USA 81, S.456-460

Lipp, J. et al. 1989 "Structural requirements for membrane assembly of proteins spanning the membrane several times." J. Cell Biol. 109, S.2013-2022

Lively, M. O. et al. 1994 "Eukaryote microsomal signal peptidases." Methods Enzymol. 244, S.301-314

Lyko, F. et al. 1995 "Signal sequence processing in rough microsomes.," J. Biol. Chem. 270, S.19873-19878

Lyman, S. K. and Schekman, R. 1997 "Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP." Cell 88, S.85-96

Matlack, K. E. et al. 1997 "Protein transport by purified yeast Sec complex and Kar2p without membranes." Science 277, S.938-941

Matlack, K. E. et al. 1999 "BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane." Cell 97, S.553-564

Mellquist, J. L. et al. 1998 "The amino acid following an asn-X-Ser/Thr sequon is an important determinant of N-linked core glycosylation efficiency." Biochemistry 37, S.6833-6837

Meyer, D. I. et al. 1982 "Secretory protein translocation across membranes-the role of the "docking protein'." Nature 297, S.647-650

Meyer, H. A. and Hartmann, E. 1997 "The yeast SPC22/23 homolg Spc3p is essential for signal peptidase activity." J. Biol. Chem. 272, S.13159-13164

Misselwitz, B. et al. 1998 "J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences." Mol. Cell 2, S.593-603

Mothes, W. et al. 1994 "Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane." EMBO J. 13, S.3973-3982

Mothes, W. et al. 1997 "Molecular mechanism of membrane protein integration into the endoplasmic reticulum." Cell 89, S.523-533

Mothes, W. et al. 1998 "Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane." J Cell Biol 142, S.355-364

Müller, G. and Zimmermann, R. 1988 "Import of honeybee prepromelittin into the endoplasmic reticulum: energy requirments for membrane insertion." EMBO J. 7, S.639-648

Mullins, C. et al. 1995 "A mutation affecting signal peptidase inhibits degradation of an abnormal membrane protein in Saccharomyces cerevisiae.," J. Biol. Chem. 270, S.17139-17147

Mullins, C. et al. 1996 "Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct." J. Biol. Chem. 271, S.29094-29099

Müsch, A. et al. 1992 "Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane." Cell 69, S.343-352

Ng, D. T. and Walter, P. 1996 "ER membrane protein complex required for nuclear fusion." J. Cell Biol. 132, S.499-509

Ng, D. T. et al. 1996 "Signal sequences specify the targeting route to the endoplasmic reticulum membrane." J Cell Biol 134, S.269-278

Nicchitta, C. V. et al. 1995 "Stage- and ribosome specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane." J Cell Biol 129, S.957-970


Nilsson, I. and von Heijne, G. 1992 "A signal peptide with a proline next to the cleavage site inhibits leader peptidase when present in a sec-independent protein." FEBS Lett. 299, S.243-246

Noel, P. and Cartwright, I. L. 1994 "A Sec62p-related component of the secretory protein translocon from Drosophila displays developmentally complex behavior." EMBO J. 13,

Nunnari, J. et al. 1997 "A mitochondrial protease with two catalytic subunits of nonoverlapping specificities." Science 262, S.1997-2004

Paetzel, M. et al. 1997 "Use of site-directed chemical modification to study an essential lysine in Escherichia coli leader peptidase." J. Biol. Chem. 272, S.9994-1000

Paetzel, M. et al. 1998 "Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor." Nature 396, S.186-190

Palade, G. 1975 "Intracellular aspects of the process of protein secretion." Science 189, S.347-358

Panzner, S. et al. 1995 "Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p." Cell 81, S.561-570

Pilon, M. et al. 1997 "Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation." EMBO, J. 16, S.4540-4548

Plath, K. et al. 1998 "Signal sequence recognition in posttranslational protein transport across the yeast ER membrane." Cell 94, S.795-807

Plemper, R. K. et al. 1997 "Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation." Nature 388, S.891-895

Pohlschröder, M. et al. 1997 "Protein translocation in the three domains of life: variations on a theme." Cell 91, S.563-566

Prehn, S. et al. 1989 "Structure and biosynthesis of the signal-sequence receptor." Eur. J. Biochem. 188, S.439-445

Prinz, A. et al. 2000 "Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA." EMBO J. 19, S.1900-1906

Rapiejko, P. J. and Gilmore, R. 1997 "Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum." Cell 89, S.703-713

Robinson, J. S. et al. 1988 "Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases." Mol. Cell. Biol. 11, S.4936-4948

Rothblatt, J. A. et al. 1987 "Secretion in yeast: structural features influencing the post-translational translocation of prepro-alpha-factor in vitro." EMBO J. 6, S.3455-3463

Rothblatt, J. A. et al. 1989 "Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast." J. Cell Biol. 109, S.2641-2652

Sadler, I. et al. 1989 "A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein." J. Cell Biol. 109, S.2665-2675

Sambrook, E. et al. 1989 "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Sanders, S. L. et al. 1992 "Sec61p and BiP directly facilitate polypeptide translocation into the ER." Cell 69, S.353-365


Schlenstedt, G. and Zimmermann, R. 1987 "Import of frog prepropeptide GLa into microsomes requires ATP but does not involve docking protein or ribosomes." EMBO J. 6, S.699-703

Schlenstedt, G. et al. 1995 "A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s." J. 129, S.979-988

Schmitz, A. et al. 2000 "Cholera toxin is exported from microsomes by the Sec61p complex." J. Cell Biol. 148, S.1203-1212

Schneider, B. L. et al. 1995 "Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae." Yeast 11, S.65-74

Scidmore, M. A. et al. 1993 "Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ." Mol. Biol. Cell 4, S.1145-1159

Shelness, G. S. and Blobel G. 1990 "Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein." J. Biol. Chem. 265, S.9512-9519

Sikorski, R. S. and Hieter, P. 1989 "A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae." Genetics 122, S.19-27

Skowronek, M. H. et al. 1999 "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog." Biol. Chem. 380, S.1133-1138

Spiess, M. 1995 "Heads or tails - what determines the orientation of proteins in the membrane." FEBS Lett. 369, S.76-79

Stirling, C. J. et al. 1992 "Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum." Mol. Biol. Cell 3, S.129-142

Sung, M. and Dalbey, R. E 1992 "Protein identification of potential active-site residues in the Escherichia coli leader peptidase." J. Biol. Chem. 267, S.13154-13159

Tschantz, W. R. et al. 1993 "A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase." J. Biol. Chem. 268, S.27349-27354

Van Dijl, J. M. et al. 1992). "Signal peptidase I of Bacillus subtilis: patterns of conserved amino acids in prokaryotic and eukaryotic type I signal peptidases." EMBO J. 11, S.2819-2828

van Valkenburgh, C. et al. 1999 "The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases.," J. Biol. Chem. 274, S.11519-11525

Varki, A. 1993 "Biological roles of oligosaccharides: all of the theories are correct." Glycobiology 3, S.97-13

Vogel, J. P. et al. 1990 "Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast." J. Cell Biol. 110, S.1885-1895

Voigt, S. et al. 1996 "Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane." J Cell Biol 134, S.25-35

von Heijne, G. 1985 "Signal sequences. The limits of variation." J. Mol. Biol. 184, S.99-10

von Heijne, G. 1990 "Protein targeting signals." Curr. Opin. Cell Biol. 2, S.604-608

von Heijne, G. 1995 "Protein sorting signals: simple peptides with complex functions." EXS 73, S.67-76


Walter, P. and Blobel, G. 1980 "Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum." Proc. Natl. Acad. Sci. U.S.A. 77, S.7112-7116

Walter, P. and Blobel, G. 1981 "Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes." J. Cell Biol. 91, S.545-561

Walter, P. and Blobel, G. 1982 "Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum." Nature 299, S.691-698

Walter, P. et al. 1981 "Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in vitro assembled polysomes synthesizing secretory protein." J. Cell Biol. 91, S.545-550

Wickner, W. T. and Lodish, H. F. 1985 "Multiple mechanisms of protein insertion into and across membranes." Science 230, S.400-407

Wiedmann, M. et al. 1988 "Post-translational transport of proteins into microsomal membranes of Candida maltosa." EMBO, J. 7, S.1763-1768

Wiertz, E. J. et al. 1996 "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction." Nature 384, S.432-438

Wilkinson, B. M. et al. 1996 "Determination of the transmembrane topology of yeast Sec61p, an essential component of the endoplasmic reticulum translocation complex." J. Biol. Chem 271, S.25590-25597

Wittke, S. et al. 1999 "Probing the molecular environment of membrane proteins in vivo." Mol. Biol. Cell. 10, S.2519-2530

Wolfe, P. B. et al. 1985 "Effects of two sec genes on protein assembly into the plasma membrane of Escherichia coli." J Biol Chem. 260, S.1836-1841

YaDeau, J. T. and Blobel, G. 1989 "Solubilization and characterization of yeast signal peptidase." J. Biol. Chem. 264, S.2928-2934

YaDeau, J. T. et al. 1991 "Yeast signal peptidase contains a glycoprotein and the Sec11 gene product." Proc. Natl. Acad. Sci. USA. 88, S.517-521

Zimmermann, R. and Mollay, C. 1986 "Import of honeybee prepromelittin into the endoplasmic reticulum. Requirements for membrane insertion, processing, and sequestration.," J. Biol. 261, S.12889-12895

Zimmermann, R. et al. 1990 "Ribonucleoparticle-independent import of proteins into mammalian microsomes involves a membrane protein which is sensitive to chemical alkylation." Biochimie 72, S.95-10

Zwizinski, C. and Wickner, W. 1980 "Purification and characterization of leader (signal) peptidase from Escherichia coli." J. Biol. Chem. 255, S.7973-7977

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.

DiML DTD Version 2.0
Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML - Version erstellt am:
Fri Feb 7 16:58:24 2003