[Seite 67↓]

Literaturverzeichnis

Ahnert-Hilger, G. und Bigalke, H. (1995) Molecular aspects of Tetanus and Botulinum Neurotoxin Poisoning. Prog. in Neurobiol., 46, 83-96.

Ahmed, S.N., Brown, D.A. und London, E. (1997) On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes. Biochem., 36, 10944-10953.

Arikawa, K., Molday, L.L., Molday, R.S., Williams, D.S. (1992) Localisation of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration. J. Cell Biol, 116, 659- 667.

Barres, B.A. und Smith, S.J. (2001) Cholesterol – Making or Breaking the Synapse. Science, 294, 1296-1297.

Barnstable, C.J., Hofstein, R., Akagawa, K. (1985) A marker of early amacrine cell development in rat retina. Dev. Brain Res., 20, 286-290.

Becher, A., Drenckhahn, A., Pahner, I., Margittai, M., Jahn, R., Ahnert-Hilger, G. ( 1999) The synaptophysin-synaptobrevin-complex: a hallmark of synaptic vesicle maturation. J. Neurosci., 19, 1922-1931.

Becher, A., Drenckhahn, A., Pahner, I., Ahnert-Hilger, G. (1999) The synaptophysin-synaptobrevin-complex is developmentally upregulated in cultivated neurons but is absent in neuroendocrine cells. Europ. J. Cell, 78, pp 650-656.

Bennett, M.K., Calakos, N., Scheller, R.H. (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science, 257, 255-259.

Brown, D.A. and London, E. (1998) Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol., 14, 111-36.

Brown, D.A. and London, E. (2000) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem., 275, 17221-17224.

Calakos, N., Bennett, M.K., und Scheller, R.H. (1994) Protein-protein interactions contributing to the specificity if intracellular vesicular trafficking. Science, 263, 1146-1149.

Carstea, E.D., Morris, J.A., Coleman, K.G., Loftus, S.K., Zhang, D., Cumming, C., Gu, J., Rosenfeld, M.A., Pavan, W.J., Krizman, D.B. (1997) Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science, 277, 228-231.

Chamberlain, L.H., Burgoyne, R.D., Gould, G.W. (2001) SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis. PNAS, 98, 5619-5624.


[Seite 68↓]

Chapman, E.R., An, S., Barton, N., und Jahn, R. (1994) SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. J. Biol. Chem., 269, 27427-27432.

Connell, G.J. und Molday, R.S. (1990) Molecular cloning, primary structure and orientation of the vertebrate photoreceptor cell protein Peripherin in the rod outer segment disk membrane. Biochem., 29, 4691-4698.

Cremona, O. und de Camilli, P. (1997) Synaptic vesicle endocytosis. Curr. Opin. Neurobiol., 7, 323-330.

Cruzeiro-Hansson, L., Ipsen, J.H. und Mouritsen, O.G. (1989) Intrinsic molecules in lipid membranes change the lipid-domain interfacial area: cholesterol at domain interfaces. Biochem. Biophys. Acta, 979, 166-176.

Edelmann, L., Hanson, P.I., Chapman, E.R., and Jahn, R. (1995) Synaptobrevin binding to Synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO J., 14, 224-231.

Edwards, R.H. (1992) The transport of neurotransmitters into synaptic vesicles. Curr. Opin. Neurobiol., 2, 586-594.

Elferink, L.A., Trimble, W.S., Scheller, R.H. (1998) Two vesicle-associated membrane protein genes are differentially expressed in rat central nervous system. J. Biol. Chem., 264, 11061-11064.

Eshkind, L.E., und Leube, R.E. (1995) Mice lacking Synaptophysin reproduce and form typical synaptic vesicles. Cell Tissue Res., 282, 423-433.

Fasshauer, D., Bruns, D., Shen, B., Jahn, R., und Brünger, A.T. (1997) A structural change occurs upon binding of syntaxin to SNAP-25. J. Biol. Chem., 272, 4528-4590.

Frontali, N., Ceccarelli, B., Gorio, A., Mauro, A., Siekevitz, P., Tzeng, M.-C. and Hurlbeut, W.P. (1976) Purification from black widow spider venom of a protein factor causing the depletion of synaptic vesicles at neuromuscular junction. J. Cell Biol., 68, 462-479.

Galli, T., Garcia, E.P., Mundigl, O., Chilcote, T.J., De Camilli, P. (1995) V- and t-SNAREs in neuronal exocytosis: a need for additional components to define sites of release. Neuropharmacology, 43, 1351-1360.

Garcia, E.P., McPherson, P.S., Chilcote, T.J., Takei, K. und De Camilli, P. (1995) rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. J. Cell Biol., 129, 105-120.

Ge, M., Field, K.A., Aneja, R., Holowka, D., Baird, B., Freed, J.H. (1999) Electron spin resonance characterization of liquid ordered phase of detergent-resistant membranes from RBL-2H3 cells. Biophys. J., 77, 925-933.

Gimpl, G., Burger, K., Fahrenholz, F. (1997) Cholesterol as Modulator of Receptor Function. Biochem., 36, 10959-10974.


[Seite 69↓]

Hanson, P.I., Roth, R., Morisaki, H., Janh, R., Heuser, J.E. (1997) Structure and conformational changes in NSF and in its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell, 90, 523-535.

Hayashi, T., McMahon, H., Yamasaki, S., Binz, T., Hata, Y., Südhof, T.C., und Niemann, H. (1994) Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J., 13, 5051-5061.

Hinz, B., Mitter, D., Becher, A., Schulze, K., Heinemann, U., Draguhn, A., Ahnert-Hilger, G. (2000) Is the synaptphysin/synaptbrevin-complex relevant for synaptic plasticity? Xth Magdeburg International neurobiological Symposium: Mechanisms of Learning and Memory.

Hinz, B., Becher, A., Mitter, D., Schulze, K., Heinemann, U., Draguhn, A., Ahnert-Hilger, G. (2001) Activity-dependent changes of the presynaptic synaptophysin-synaptobrevin complex in adult rat brain. Europ. J. Cell Biol., 80, 615-619.

Hurlbut, W.P., Chieregatti, E., Valtorta, F. and Haimann, C. (1994) Alpha-Latrotoxin channels in neuroblastoma cells. J. Membr. Biol., 138, 91-102.

Huttner, W.B. (1983) Synapsin I , a nerve terminal-specific phosphoprotein. J. Cell Biol., 96, 1374-1388.

Höltje, M, von Jagow, B., Pahner, I., Lautenschlager, M., Hörtnagl, H., Nürnberg, B., Jahn, R., und Ahnert-Hilger, G. (2000) The neuronal monoamine transporter VMAT2 is ragulated by the trimeric GTPase Go2. J. Neurosci., 20, 2131-2141.

Ilangumaran, S. and Hoessli, D.C. (1998) Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem. J., 335, 433-440.

Incardano, J.P., Eaton, S. (2000) Cholesterol in signal transduction. Cell Biol., 12, 193-203.

Jahn, R., Südhof, T.C. (1994) Synaptic vesicles and exocytosis. Ann. Rev. Neurosci., 17, 219-246.

Jahn, R., Südhof, T.C. (1999) Membrane fusion and exocytosis. Ann. Rev. Biochem., 68, 219-246.

Janz, R., Südhof, T.C., Hammer, R.E., Unni, V., Siegelbaum, S.A., Bolshakov, V.Y. (1999) Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron, 24, 687-700.

Johnston, P.A., Jahn, R., Südhof, T.C. (1989) Transmembrane topography and evolutionary conservation of synaptophysin. J. Biol. Chem., 264, 1268-1273.

Kee, Y., Lin, R.C., Hsu, S.C., und Scheller, R.H. (1995) Distinct Domains of Syntaxin are Required for Synaptic Vesicle Fusion Complex Formation and Dissociation. Neuron, 14, 991-998.

Keller, P. und Simons, K. (1998) Cholesterol is required for surface transport of influenza virus hemagglutinin. J. Cell Biol., 140, 1357-1367.


[Seite 70↓]

Khvotchev, M. und Südhof, T.C. (2000) Alpha-Latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma terminal. EMBO J., 19, 3250-3262.

Kobayashi, T., Beuchat, M.L., Frias, S., Palmiter, R.D., Sakuraba, H., Parton, R.G., Gruenberg, J. (1999) Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nature Cell Biol., 1, 113-118.

Laemmli, U.K. (1970) Cleavage of structural proteine during assembly of the head bacteriophage T4. Nature, 227, 680-685.

Lang, T., Bruns, D., Wenzel, D., Riedel, D., Holoroyd, P., Thiele, C. und Jahn, R. (2001) SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. EMBO J., 20, 2202-2231.

Lange, Y., Swaisgood, M.H., Ramos, B.V., und Steck, T.L. (1989) Plasmamembranes contain half the phospholipids and 90 % of the cholesterol and sphingomyelin in cultured human fibroblasts. J. Biol. Chem., 264, 3786-3793.

Leppimaeki, P., Kronqvist, R. und Slotter, P. (1998) The rate of sphingomyelin synathesis de novo by level of cholesterol in cultured human skin fibroblasts. Biochem. J., 335, 285-291.

Leube, R.E., Kaiser, P., Seiter, A., Zimbelmann, R., Franke, W.W., Rehm, H., Knaus, P., Prior, P., Betz, H., Reinke, H., Beyreuther, K., Wiedemann, B. (1987) Synaptophysin: molecular organisation and mRNA expression as determined from cloned cDNA. EMBO J., 6, 3261-3268.

Leube, R.E., Wiedenmann, B., Franke, W.W. (1989) Topogenesis and sorting of synaptophysin: synthesis of a synaptic vesicle protein from a gene transfected into nonneuroendocrine cells. Cell, 59, 13488-13492.

Leveque, C., Pupier, S., Marqueze, B., Geslin, L., Kataoka, M., Takahashi, M., De Waard, M., Seagar, M. (1998) Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel. J. Biol. Chem., 273, 13488-13492.

Lin, R.C., Scheller, R.H. (2000) Mechanism of synaptic vesicle exocytosis Ann. Rev. Cell Dev. Biol., 16, 19-46.

Liscum, L. und Munn, N.J. (1999) Intracellular cholesterol transport. Biochem. Biophys. Acta, 1438, 19-37.

Loftus, S.K., Morris, J.A., Carstea, E.D., Gu, J.Z., Cummings, C., Brown, A., Ellison, J., Ohno, K., Rosenfeld, M.A., Tagle, D.A. (1997) Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science, 277, 232-235.

Martin, T.F.J. (2000) Racing lipid rafts for synaptic-vesicle formation. Nature Cell Biol., 2, E9-E11.

Mauch, D.H., Nägler, K., Schumacher, S., Göritz, C., Müller, E., Otto, A., Pfrieger, F.W. (2001) CNS Synaptogenesis Promoted by Glia-Derived Cholesterol. Science, 294, 1354-1357.


[Seite 71↓]

McMahon, H.T., Ushkaryov, Y.A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, R., Südhof, T.C. (1993) Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature, 364, 346-349.

Mollinedo, F. und Lazo, P.A. (1997) Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. Biochem. Biophys. Res. Com., 231, 808-812.

Montine, T.J., Montine, K.S., and Swift, L.L. (1997) Central nervous system lipoproteins in Alzheimer's disease. Am. J. Pathol., 151, 1571-1575.

Mukherjee, S. and Maxfield, F.R. (1999) Cholesterol: stuck in traffic. Nature Cell Biol., 1, E37-E38.

Murthy, V.N. und Stevens, C.F. (1998) Synaptic vesicles retain their identity through the endocytotic cycle. Nature, 392, 497-501.

Neufeld, E.B., Wastrey, M., Patel, S., Suresh, S., Cooeney, A.M., Dwyer, N.K., Roff, C.F., Ohno, K., Morris, J.A., Carstea, E.D. (1999) The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J. Biol. Chem., 274, 9627-9635.

Niemann, H., Blasi, J. und Jahn, R. (1994) Clostridial neurotoxins: New tools for dissecting exocytosis. Trends Cell Biol., 4, 179-185.

Okamoto, T., Schlegel, A., Scherer, P.E., Lisanti, M.P. (1998) Caveolins, a family of scaffolding proteins for organizing ‚preassembled signaling complexes‘ at the plasma membrane. J. Biol. Chem., 273, 5419-5422.

Otto, H., Hanson, P.I., Jahn, R. (1997) Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles. Proc. Natl. Acad. Sci. USA, 19, 6197-6201.

Ovchinikov, Y.A., Abdulaev, N.G., Zolotarev, A.S., Artamonov, I.D., Bespalov, I.A., Dergachev, A.E., Tsuda, M. (1988) Octopus rhodopsin: amino acid sequence deduced from cDNA. FEBS Lett., 232, 69-72.

Pang, L., Graziano, M.M. and Wang, S. (1999) Membrane Cholesterol Modulates Galanin-GalR2 Interaction. Biochem., 38, 12003-12011.

Pevsner, J., Hsu, S.C., Braun, J.E., Calakos, N., Ting, A.E:, Bennett, M.K., und Scheller, R.H. (1994) Specificity and Regulation of a Synaptic Vesicle Docking Complex. Neuron, 13, 353-361.

Ravichandran, V., Chawla, A., Roche, P.A. (1996) Identification of a novel syntaxin- and synaptobrevin/VAMP binding-protein, SNAP-23, expressed in non-neuronal tissue. J. Biol. Chem., 271, 13300-13303.

Rothman, J.E. (1994) Mechanisms of intracellular protein transport. Nature, 372, 55-63.

Rothberg, K.G., Ying, Y.S., Kamen, B.A.. und Anderson, R.G.W. (1990) Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J. Cell. Biol., 111, 2931-2938.


[Seite 72↓]

Roy, S., Luetterforst, R., Harding, A., Apolloni, A., Etheridge, M., Stang, E., Rolls, B., Hancock, B., Parton, R.G. (1999) Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat. Cell Biol., 1, 98-105.

Röper, K., Corbeil, D., Huttner, W.B. (2000) Retention of Promininin microvilli reveals distinct cholesterol-based lipid microdomains in the apical plasma membrane. Nature Cell Biol., 2, 582-592.

Schnitzer, J.E., Oh, P., Pinney, E. und Allard, J. (1994) Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endozytosis, and capillary permeability of select macromolecules. J. Cell Biol., 127, 1217-1232.

Sheets, E.D., Holowka, D., Baird, B. (1999) Membrane organization in immunglobulin E rezeptor signalling. Curr. Opin. Chem. Biol., 3, 95-99.

Simons, K. und Ikonen, E. (1997) Functional rafts in cell membranes. Nature, 387, 569-572.

Spiwoks-Becker, I., Vollrath, L., Seeliger, M.W., Jaissle, G., Eshkind, L.G. und Leube, R.E. (2001) Synaptic vesicles alterations in Rod Photoreceptors of Synaptophysin-deficient mice. Neuroscience, 107, 127-142.

Simons, K. und van Meer, G. (1988) Lipid sorting in epithelial cells. Biochem., 27, 6197-6202.

Smith, P.K., Krohn, R.I., Hermanson, G.T. Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J., Klenk, D.C. (1985) Measurement of protein using biochoninic acid. Anal Biochem., 150, 76-85.

Söllner, T., Bennet, M.K., Whiteheart, S.W., Scheller, R.H. und Rothman, J.E. (1993) A Protein Assembly-disassembly Pathway In Vitro That May Correspond to Sequential Steps of Synaptic Vesicle Docking, Activation, and Fusion. Cell, 75, 409-418.

Südhof, T.C., Baumert, M., Perin, M.S., Jahn, R. (1998) A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron, 2, 1475-1481.

Sugita, S., Janz, R., Südhof, T.C. (1999) Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells. J. Biol. Chem., 274, 18893-18901.

Thiele, C., Hannah, M.J., Fahrenholz, F., Huttner, W.B. (2000) Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Nature Cell Biol., 2, 42-49.

Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W.W., Betz, H. (1988) Identification of synatophysin as a hexameric channel protein of the synaptic vesicle membrane. Science, 242, 1050-1053.

Trimble, W.S., Cowan, D.M., Scheller, R.H. (1988) VAMP-1: A synaptic vesicle-associated integral membrane protein. Natl. Acad. Sci. USA, 85, pp 4538-4542.

Ullian, E.M., Sapperstein, S., Christopherson, K.S., Barres, B.A. (2001) Control of Synapse Number by Glia. Science, 291, pp 657-661.


[Seite 73↓]

Veit, M., Becher, A., Ahnert-Hilger, G. (2000) Synaptobrevin 2 is palmitoylated in synaptic vesivles prepared from adult, but not from embryonic brain. Mol. Cell Neuroscience, 15, 408-416.

Walch-Solimena, C., Blasi, J., Edelmann, L., Chapman, E.R., Fischer von Mollare, G. und Jahn, R. (1995) The t-SNAREs Syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling. J. Cell Biol., 128, 637-645.

Wanke, E., Ferroni, A., Gattanini, P. and Meldolesi, J. (1986) Alpha-Latrotoxin of the black widow spider venom opens a small, non-closing cation channel. Biochem. Biophys. Res. Commun., 134, 320-324.

Wiedemann, B. und Franke, W.W. (1985) Identification and localisation of synaptophysin: An integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell, 41, 1017-1028.

Wu, L.G. und Borst, J.G. (1999) The reduces release probability of releasable vesicles during recovery from short-term synaptic depression. Neuron, 23, 821-832.

Yoshida, A., Oho, C., Omori, A., Südhof, T.C., Anderson, R.G.W. (1994) HPC-1 is associated with synaptotagmin and w-conotoxin receptor. Cell, 78, 751-760.

Zenisek, D., Steyer, J.A. und Almers, W. (2000) Transport, capture and exocytosis of single synaptic vesicles at active zones. Nature, 406, 849-854.

Zucker, R.S. (1996) Exocytosis: a molecular and physiological perspective. Neuron, 17, 1049-1055.


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