[page 117↓]


Abraham, D., Podat, K., Pacher, M., Kubicek, M., Welzel, N., Hemmings, B., Dilworth, SM., Mishak, H., Koch, W., Baccarini, M. Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. J Biol Chem. 2000, 275; 22300-22304

Adam, PJ., Boyd, R., Tyson, KL., Fletcher, GC., Stamps, A., Hudson, L., Poyser, HR., Redpath, N., Griffiths, M., Steers, G., Harris, AL., Patel, S., Berry, J.,Loader, JA, Townsend, RR., Daviet, L., Legrain, P., Parekh, R., Terrett, JA. Comprehensive proteomic analysis of breast cancer cell membranes revelas unique proteins with potential roles in clinic cancer. J Biol Chem. 2003, 278 (8); 6482-6489

Adams, JM., Cory, S. Oncogene co-operation in leukaemogenesis. Cancer Surv. 1992, 15; 119-141

Afshari, CA., Kodama, S., Bivins, HM., Willard, TB., Fujiki, H., Barrett, JC. Induction of neoplastic progression of Syrian hamster embryo cells treated with protein phosphatase inhibitors. Cancer Res. 1993, 53(8); 1777-1782

Akiyama, H., Hiraki, Y., Noda, M., Shigeno, C., Ito, H., Nakamura, T. Molecular cloning and biological activity of a novel HA-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using cloned mouse EC cells, ATDC5. J Biol Chem. 1999, 274(45); 32192-32197

Alberts, AS., Deng, T., Lin, A., Meinkoth, JL., Schonthal, A., Mumby, MC., Karin, M., Feramisco, JR. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol Cell Biol. 1993, 13; 2104-2112

Alberts, AS., Thorburn, AM., Shenolikar, S., Mumby, MC., Feramisco, JR. Regualtion of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci USA. 1993, 90; 388-392

Alessi, DR., Gomez, N., Moorhead, G., Lewis, T., Keyse, SM., Cohen, P. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Curr Biol. 1999, 5; 283-295

Al-Murrani, SW., Woodgett, JR., Damuni, Z. Expression of I2PP2A, an inhibitor of protein phosphatase 2 A, induces c-Jun and AP-1 activity. Biochem J. 1999, 34 (1); 293-298

Anantharaman, V., Aravid, L. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biology. 2003, 4; RII

Andjelkovic, N., Zolnierowicz, S., Van Hoof, C., Goris, J., Hemmings, BA. The catalytic subunit of the protein phosphatase 2A associates with the translation termination factor eRF1. EMBO J. 1996, 15(24); 7156-7167

[page 118↓]

Aronheim, A., Zandi, E., Hennemann, H., Elledge, SJ., Karin, M. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997, 17(6) ; 3094-30102

Ayllon, V., Martinez, AC., Garcia, A., Cyala, X., Rebollo, A. Protein phosphatase 1 alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. EMBO J. 2000, 19; 2237-2246

Baldwin, RL., Nemeth, E., Tran, H., Shvartsman, H., Cass, I., Narod, S., Karlan, BY. BRCA1 promoter region hypermethylation on ovarian carcinoma: a population-based study. Cancer Res. 2000, 60(19); 5329-5333

Baylin, SB., Herman, JG., Graff, JR., Vertino, PM., Issa, JP. Alteration in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res. 1998, 72; 141-196

Beckmann, MW., Niederacher, D., Schnurch, HG., Gusterson, BA., Bender, HG. Multistep carcinogenesis of breast cancer and tumour heterogeneity. J Mol Med. 1997, 75(6); 429-439

Bennin, DA., Arachchige Don, AS., Brake, T., McKenzie, JL., Rosenbaum, H., Ortz, L., DePaoli-Roach, AA., Horne, MC. Cyclin G2 Assiciates with Protein Phosphatase 2A Catalytic and Regulatory B' Subunit in Active complexes and Induces Nuclear Aberrations and G1/S Phase Cell Cycle Arrest. J Biol Chem. 2002, 227(30); 27449-27467

Beretta, L., Gabbay, M:, BErger, R., Hanash, SM., Sonenberg, N. Expression of the protein kinase PKR is modulated by IRF-1 and is reduced in 5q-associated leukemias. Oncogene. 1996, 12(7); 1593-1596

Berta, GN., Ghezzo, F., D'Avolio, A. Enhancement of calcyclin geneRNAexpression in squamous cell carcinoma of the oral mucaose, but bot in benign lesions. J Oral Pathol Med. 1997, 26; 206-210

Bilder, D., Perrimon, N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 2000, 40; 3 676-680

Bider, D., Li, M., Perrimon. N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000, 289; 113-116

Bird, AP. Gene number, noise reduction and biological complexity. Trends Genet. 1995, 11; 94-100

Bishop, JM. Molecular themes in oncogenesis. Cell. 1991, 64; 235-248

Bishop, JM. Cancer: the rise of the genetic paradigm. Genes Dev. 1995, 9(11); 1309-1315

Bishop, JM. Cellular oncogenes and retroviruses. Annu Rev Biochem. 1983, 52; 301-354

Bist, A., Fielding, CJ., Fielding, PE. p53 regulated cavelin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry. 2000, 39; 1966-1972

[page 119↓]

Bosch, M., Cayla, X., Van Hoof, C., Hemmings, BA., Ozon, R., Merlevede, W., Goris, J. The PR55 and PR65 subunits of protein phosphatase 2A from Xenopus laevis. Molecular cloning and developmental regulation of expression. Eur J Biochem. 1995, 230(3); 1037-1045

Boultwood, J., Fidler, C., Lewis, S., MacCarthy, A., Sheridan, H., Kelly, S., Oscier, D., Buckle, VJ., Wainscoat, JS. llelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q-chormosome in some patients with the 5q-syndrome. Blood. 1993, 82; 2611-2616

Brachmann, RK., Vidal, M., Boeke, JD. Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proc. Natl. Acad. Sci. USA. 1996, 93; 4091-4095

Breitman, TR., Gallo, RC. New facts and speculation on human myeloid leikemias. Blood Cells. 1981, 7(1); 79-89

Breitman, TR., Gallo, RC. New facts and speculation on human myeloid leikemias. Blood Cells. 1981, 7(1); 79-89

Breitman, TR., Gallo, RC. New facts and speculation on human myeloid leikemias. Blood Cells. 1981, 7(1) ; 79-89

Bronckart, Y., Decaestecker, C., Nagy, N., Harper, L., Schafer, BW., Salmon, I., Pochet, R., Kiss, R., Heizman, CW. Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins. Histolpathol. 2001, 16; 707-712

Brown, MA., Solomon, E. Towards cloning the familial breast-ovarian cancer gene on the chromosome 17. Curr Opin Genet Dev. 1994, 3; 439-445

Burke, F., Smith, PD., Crompton, MR., Upton, C., Balkwill, FR. Cytotoxic response of ovarian cancer cell lines to IFN-gamma is associated with sustained induction of IRF-1 and p21 mRNA. Br J Cancer. 1999, 80(8); 1236-1244

Burns, TF., Bernhard, EJ., El-Deiry, WS. Tissue specific expression of p53 target genes suggests the key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene. 2001, 20; 4601-4612

Calabretta, B., Kaczmarck, I., Mars, W. Cell-cycle specific genes differentially expressed in human leukemias. Proc Natl Acad USA. 1985, 82; 4463-4467

[page 120↓]

Calin, GA., di Iasio, MG., Caprini, E., Vorechovsky, I., Natali, PG., Sozzi, G., Croce, CM., Barbanti-Brodano, G., Russo, G., Negrini. M. Low frequency of alteration of the alpha (PPP2R1A) and beta (PPP2R1B) isoformes of the subunit A of the serine-threonine phosphatase 2A in human neoplasm. Oncogene. 2000, 19; 1191-1195

Cameron, EE., Bachman, KE., Myohanen, S., Herman, JG., Baylin, SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet. 1999, 21(1); 103-107

Casey, G., Lo-Hsueh, M., Lopez, ME., Vogelstein, B., Stanbridge, EJ. Growth suppression of human breast cancer cells by introduction of a wild-type p53 gene. Oncogene. 1991, 10; 1791-1797

Chelbi-Alix, MK., Pelicano, L. Retinoc acid and interferon signaling cross talk in normal and RA-resistant APL cells. Leukemia. 1999, 11; 1167-1774

Chen, AC., Guo, X., Derguini, F., Gudas, IJ. Human breast cancer cells and normal mammary epithelial cells: retinoid metabolism and growth inhibition by the retinol metabolite 4-oxoretinol. Cancer Research. 1997, 57; 4642-4651

Chen, B., He, L., Savell, VH., Jenkins, JJ., Parham, DM. Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermetilation at a STAT-binding site in the p21WAF1 promoter region. Cancer Res. 2000, 60(12); 3290-3298

Cheng, A., Balczon, R., Zuo, Z., Koons, JS., Walsh, AH., Honkanen, RE. Fostriecin-mediated G2-M-phase growht arrest correlates with abnormal centorsome replication, the formation of abberant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity. Cancer Res. 1998, 58(16); 3611-3619

Chiang, CW., Harris, G., Elling, C., Martesr, SC., Subramanian, R., Shenolikar, S., Wadzinski, BE., Yang, E. Protein phosphatse 2A activates the proapoptotic function of BAD in interleukin-3-dependent lymphoid cells by a mechanism requiring14-3-3 dissociation. Blood. 2001, 97; 1289-1297

Chung, YW., Jeong, DW., Won, JY., Choi, EJ., Choi, YH., Kim. IY. H(2)O(2)-induced AP-1 activation and its effects on p21(WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cell. Biochem Biophys Res Commun. 2002, 293(4); 1248-1253

Cicchilliti L., Fasanaro, P., Biglioli, P., Capagrossi, MC., Martelli, F. Oxidative stress induces PP2A-edpendent de-phosphorylataion of the pocket proteins pRb, p107 and p130. J Biol Chem. 2003, epub ehead of print

Cizdziel, PE., Hosoi, J., Montgomery, JC., Wiseman, RW., Barrett, JC. Loss of a tumor suppressor gene function is correlated with downregulation of chondrocyte-specific collagen expression in Syrian hamster embryo cells. Mol Carcinog. 1991, 4; 14-24

[page 121↓]

Coccia, EM., Del Russo, N., Stellacci, E., Orsatti, R., Benedetti, E., Marziali, G., Hiscott, J., Battistini, A. Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2. Oncogene. 1999, 18; 2129-2137

Cordo-Cardo, C., Richon, VM. Expression of the retinoblastoma protein is regulated in normal human tissues. Am J Pathol. 1994, 144; 500-510

Coughlin, CM., Salhany, KE., Gee, MS., La Temple, DC., Kotenko, S., Ma, X., Gri, G., Wysocka, M., Kim, JE., Liu, L., Liao, F., Farber, JM., Pestka, S., Trinchieri, G., Lee, WM. Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and atiangiogenesis. Immunity. 1998, 9; 25-34

Csiszar, K., Fong, SF., Ujfalusi, A., Krawetz, SA., Salvati, EP., Mackenzie, JW., Boyd, CD. Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. Int J Cancer. 2002, 97; 636-642

Dameron, KM., Volpert, OV., Tainsky, MA., Bouk, N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 1994, 265; 1582-1584

de The, H., Vivanco-Ruiz, MDM., Tiollais, P., Stunnenberg, H., Dejean, A. Identification of a retinoic acid- responsive elements in the retinoic acid receptor beta gene. Nature. 2000, 343; 177-180

Deloulme, JC., Assard, N., Mbele, GO., Mangin, C., Kuwano, R., Baudier, J. S100A6 and S100A11 are specific targets of the calcium- and zink-bindimg S100B protein in vitro. The Journal of Biological Chemistry. 2000, 275; 35302-35310

Deucher, A., Nagpal, S., Chandraratna, RA., Di Sepio, D., Robinson, NA., Dashti, SR., Eckert, RL. The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localisation and optimal biological activity. Int J Oncol. 2000, 17(6); 1195-1203

DiSepio, D., Ghosn, C., Eckert, RE., Deucher, A., Robinson, N., Duvic, M., Chandraratna, R., Nagpal, S. Identification and characterization of a retinoid-induced class II tumor supressor/growth regulatory gene. Cell Biol. 1998, 95; 14811-14815

Diatchenko, L., Lau, YF., Camobell, AP., Chenchik, A., Mogadam, F., Huang, B., Lukyanov, S., Lukyanov, K., Gurskaya, N., Sverdlov, ED., Siebert, PD. Suppression substractive hybridization: a method for generating differentially regulated or tissue-specifis cDNA probes and libraries. Proc Natl Acad Sci USA. 1996, 93(12); 6025-6030

Doherty, GM., Boucher, L., Sorenson, K., Lowney, J. Interferon regulatory factor expression in human breast cancer. Ann. Surg. 2001, 233; 623-629

Duronio, V., Scheud, MP., Ettinger, S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal. 1998, 10; 233-239

[page 122↓]

Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998, 12; 2245-2262

Ebina, Y., Takahara, Y., Kishi, F., Nakazawa, A. LexA protein is a repressor of the colicin E1 gene. J Biol. Chem. 1993, 258; 13258-13261

el-Deiry, WS., Tokino, T., Velculescu, VE., Levy, DB., Parson, R., Trent, JM., Lin, D., Mercer, WE., Kinzler, KW., Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993, 75(4); 817-825

el-Deiry, WS. Regulation of 53 down-stream genes. Semin Cancer Biol. 1998, 8; 345-357

Estojak, J., Brent, R., Golemis, E. Correlation of the two-hybrid affinity data with in vitro measurements. Mol Cell Biol. 1995, 15; 5820-5829

Evans, RM. The steroid and thyroid hormone receptor superfamily. Science. 1988, 240; 889-895

Ferrari, S., Calabretta, B., deRiep, JK., Battini, R., Ghezza, F., Lauret, E., Griffin, C., Emanuel, BS., Gurrieri, F., Baserga, RE. Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem. 1987, 262(17); 8325-8332

Fields, S., Song, O. A novel system to detect protein-protein interactions. Nature. 1989, 340; 245-246

Filipek, A., Heizmann CW., Kuznicki, J. Calcyclin is a calcium and zinc binding protein. FEBS Lett. 1990, 264(2); 263-266

Friend, SH., Horowitz, JM., Wang, XF., Bogenmann, E., Li, FP., Weinberg, RA. Deletion of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci USA. 1988, 84; 9059-9063

Frost, JA., Alberts, AS:, Sontag, E., Guan, K., Mumby, MC., Feramisco, JR. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol Cell Biol. 1994, 14; 6244-6252

Fujiki, H., Suganuma, M. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Adv Cancer Res. 1993, 61 ; 143-194

Garinis, GA., Patrinos, GP., Spanakis, NE., Menounos, PG. DNA hypermethylation: when tumor suppressor genes go to silent. Hum Genet. 2002, 111; 115-127

Ge, H., Roeder, RG. Purification, cloning, and characterisation of a human coactivator, pc4, that mediates transcriptional activation of calss II genes. Cell. 1994, 78; 513-523

Gerber, D., Shai, Y. Chirality-independent protein-protein recognition between transmembrane domains in vivo. J Mol Biol. 2002, 322; 491-495

[page 123↓]

Giampuzzi, M., Bottim G., Cilli, M., Gusmano, R., Borel, A., Sommer, P., Di Donato, A. Down-regulation of lysyl oxidase-induced tumorigenic transformation in NRK-49F cells characterised by constitutive activation of ras proto-oncogene. J Biol Chem. 2001, 276; 29226-29232

Glass, CK., Rosenfeld, MG. The coregulator exchange in transcripitional functions of nuclear receptors. Genes Dev. 2000, 14 ; 121-141

Golemis, E.A., Gyuris, J., Brent, R. Interaction trap/two-hybrid systems to identify interacting proteins. Current Protocol in Molecular Biology (John Willey & Sons, Inc.). 1994, Ch. 13.14.

Gooch, JL., Herrera, RE., Yee, D. The role of p21 in interferon gamma-mediated growth inhibtion of human breast cancer cells. Cell Growth Differ. 2000, 11(6) ; 335-342

Gotz, J., Probst, A., Ehler, E., Hemmings, B., Kues. W. Delayed embryonic lethaloty in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci USA. 1998, 95; 12370-12375

Greger, V., Debus, N., Lohmann, D., Hopping, W., Passarge, E., Horsthemke, B. Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Hum Genet. 1994, 94; 491-496

Greigel, S., Traub, O., Willecke, K., Schaefer, R. Suppression and reexpression of transformed phenotyp in hybrids HA-ras-1-transformed rat-1 cells and early-passage rat embryonic fibroblasts. Int J Cancer. 1986, 38; 697-705

Gudas, LJ. Retinoids, retinoid-responsive genes, cell differentiation, and cancer. Cell Growth Differ. 1992, 3; 655-662

Guenet, L., Totain, B., Guilleret, I., Chauvel, B., Deaven, LL., Longmire, JL., Le Gall, JY., David, V., Le Treut, A. Human release factor eRF1: structural organisation of the unique functinal gene chromosome 5 and of the three processed pseudogenes. FEBS Letters. 1999, 454; 131-136

Guo, X., Gudas, L. Metabolism of all-trans-reinol in normal human cell strains and squamous cell carcinoma (SCC) lines from oral cavity and skin: reduced esterificaion of retinol in SCC lines. Cancer Res. 1998, 166-176

Guo, X., Ruiz, A., Rando, RR., Bok, D., Gudas, LJ. Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecitin:retinol acyltransferase in carcinoma carcinogenesis. 2000, 21; 1925-1933

Gyuris, J., Golemis, E., Chertkov, H., Brent, R. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell. 1993, 75; 791-803

Haile, DT., Parvin, JD. Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain. J Biol Chem. 1999, 274 (4); 2113-2117

[page 124↓]

Hajnal, A., Klemenz, R., Schaefer, R. Up-regulation of lysyl oxidase in spontaneous revertants of H-ras-transformed rat fibroblasts. Cancer Res. 1993, 53(19); 4670-4675

Hajnal, A., Klemenz, R., Schaefer, R. Substraction cloning of H-rev107, a gene expressed in H-ras resistant fibroblasts. Oncogene. 1994, 9; 479-490

Hall, M., Peters, G. Genetic alteration of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res. 1996, 68; 67-108

Hanahan, D. and Weinberg, RA. The hallmarks of cancer. Cell. 2000, 100; 57-70

Hara, I., Taguchi, I., Miyake, H., Hara, S., Gotoh, A., Kamidino, S. Effect of retinoic acid and interferone-gamma on expression of the retinoic acid receptor in mouse renal cell carcinoma. Int J Oncol. 2001, 19(5); 959-962

Harada, H., Fujita, T., Kimura, Y., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., Taniguchi, T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind the same regulatory elements of IFN and IFN-inducible genes. Cell. 1989, 729-739

Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., Taniguchi, T. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and –2. Science. 1993, 259; 971-974

Harada, H., Kondo, T., Ogawa, S., Tamura, T., Kitagawa, M., Tanaka, N., Lamphier, MS., Hirai, H., Taniguchi, T. Acceleration exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia: a possible mechanism of tumor suppressor inactivation. Oncogene. 1994, 3313-3320

Harada, H., Taniguchi, T., Tanaka, N. The role of interferon regulatory factors in the interferon system and cell growth control. Biochimie. 1998, 80; 641-650

Hartwell, H., Goldberg, R., Silver, V. Genetics - From Genes to Genomes. Washington McGraw-Hill Companies. 1999, 0072359935 944

Hemmings, BA., Adams-Pearson, C., Maurer, F., Muller, P., Goris, J., Merlevede, W., Hplfsteenge, J., Stone, SR. Alpha- and beta- forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry. 1990, 29; 3166-3173

Hesketh, R. The oncogene and tumour suppressor gene. Second eddition London, UK Academic Press. 1997, 549

Hiltunen, MO., Koistinaho, J., Alhonen, L., Myohanen, S., Marin, S., Kosma, VM., Paakkonen, M., Janne, J. Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer. Br J Cancer. 1997, 76 ; 1124-1130

[page 125↓]

Holmes, CF., Luu, HA., Carrier, F., Schmitz, FJ. Inhibition of protein phosphatase-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region of okadaic acid important for phosphatase inhibition. FEBS Lett. 1990, 270; 216-218

Holmes, WF., Dawson, MI., Soprano, RD., Soprano, KJ. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol. 2000, 185(1); 61-67

Holt, JT., Thompson, NE., Szabo, C., Robinson-Benion, C. Growth retardation and tumor inhibition by BRCA1. Nat Genet. 1996, 12; 298-302

Hong, WK., Sprn, MB. Recent advances in chemoprevention of cancer. Science. 1997, 278; 1073-1077

Hu, W., Verschraegen, CF., Wu, WG., Nash, M., Freedman, RS., Kudelka, A., Kavanagh, JJ. Activity of ALRT1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines. Int J Gynecol Cancer . 2002, 12; 202-207

Huang, SL., Shyu, RY., Yeh, MY., Jiang, SY. Cloning and characterization of a novel retinoid-inducible gene 1 (RIG1) deriving from human gastric cells. Moll Cell Endocrinol. 2000, 159(1-2); 15-24

Huang, SL., Shyu, RY., Yeh, MY., Jiang, SY. The retinoid-inducible gene I: effect on apoptosis and mitogen-activated kinase signal pathways. Anticancer Res. 2002, 22(2A); 799-804

Huard, C., Miranda, G., Wessner, F., Bolotin, A., Hansen, J., Foster, SJ., Chapot-Chartier, MP. Characterisation of AcmB, an N-acetylglucosaminidase autolysin from Lastococcus lactis. Microbiology. 2003, 149; 695-705

Hubsman, M., Yudkovsky, G., Aronheim, A. A novel approach for the identification of protein-protein interaction with intergral membrane proteins. Nucleic Acids Research. 2001, 29; 18

Huges, PJ., Stanway, G. The 2A proteins of the three picornaviruses are related to each other and to the H-rev107 family of proteins involves in the control of cell proliferation. Journal of General Virology. 2000, 81; 201-207

Husmann, K., Sers, C., FIetze, E., Mincheva, A., Lichter, P., Schaefer, R. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. Oncogene 1998, 17; 1305-1312

Idres, N., Marill, J., Flexor, MA., Chabot, GG. Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomers. J Biol Chem. 2002, 277(35); 31491-31498

[page 126↓]

Ishihara, H., Martin, BL., Brautigan, DL., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hasimoto, K., Uemura, D., et al. Calyculin and okadaic acid: inhibtors of protein phosphatase activity. Biochem Biophys Res Commun. 1 989, 159(3); 871-877

Ito, H., Akiyama, H., Shigene, C., Nakamura, T. Isolation, characterisation, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). Cytogenet Cell Genet. 2001, 93; 36-39

Ivaska, J., Bosca, L., Parker, PJ. PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Nat Cell Biol. 2003, 5; 363-369

Janssens, V., Goris, J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J. 2001, 353; 417-439

Janssens, V., Jordens, J., Stevens, I., Van Hoof, C., Martens, E., De Smedt, H., Engelborghs, Y., Waelkens, E., Goris, J. Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B''/PR72 subunit of protein phsphotase 2A. J Biol Chem. 2003, 278(12); 10687-10706

Jeay, S., Piannetti, S., Kagan, HM., Sonenshein, GE. Lysyl oxidase inhibits ras-mediated transformation by preventign activation of NF-kappa B. Mol Cell Biol. 2003, 23; 2251-2263

Kaelin WG Jr. Functions of the retinoblastoma protein. BioEssays. 1999, 21; 950-958

Kaiser, K., Stelzer, G., Meisterernst, M. The coactovator p15(PC4) initiates trasncriptional activation during TFIIA-TFIID-promoter complex formation. EMBO J. 1995, 14; 3520-3527

Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, SC., Heyman, RA., Rose, DW., Glass, CK., Rosenfeld, MG. A CBP integrator complex mediates transcripitional activation and AP-1 inhibition by nuclear receptors. Cell. 1996, 85; 403-414

Kannan, P., Tainsky, MA. Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol Cell Biol. 1999, 19 (1); 899-908

Kannan, P., Tainsky, MA. Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol Cell Biol. 1999, 19 (1); 899-908

Kato, GJ., Barrett, J., Villa-Garcia, M., Dang, CV. An amino-terminal c.myc domain required for neoplatic transformation activates transcription. Mol Cell Biol. 1990, 10; 5914-5920

[page 127↓]

Kay, BK., Williamson, MP., Sudol, M. The impostance of being proline: the interaction of proline-rich motifs in signalling proteins with their cognate domains. FASEB J. 2000, 14(2); 231-241

Keegan, K., and Cooper, JA. Use of the two hybrid system to detect the association of the protein-tyrosine phophatase, SHPTP2, with another SH2-containing protein, Grb7. Oncogene. 1996, 12(7); 1537-1544

Kinoshita, K., Nemoto, T., Nabeshima, K., Kondoh, H., Niwa, H., Yanagida, M. The regulatory subunit of fission yeast protein phosphotase 2A (PP2A) affect cell morphogenesis, cell wall sysnthesis and cytokinesis. Genes Cells. 1996, 1; 29-45

Klein, G. Fould's dangerous idea revisited: the multistep development of tumors 40 years later: Adv Cancer Res. 1998, 7; 2 1-23

Kleinberger, T., Shenk, T. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex downregulates E1A-enhanced JunB transcription. J. Virol. 1993, 67; 7556-7560

Klumpp, S., Kriegelstein, J. Serine/threonine protein phosphatases in apoptosis. Curr Opin Pharmacol. 2002, 2(4); 458-462

Knudson, AG . Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 1971, 68; 820-823

Kolch, W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J. 2000, 351; 289-305

Komatsu, K., Andoh, A., Ishiguri, S., Suzuki, N., Hunai, H., Kobune-Fujiwara, Y., Kameyama, M., Miyoshi, J., Akedo, H., Nakamura, H. Increased expression of S100A6 (Calcyclin), a calcium-binding protein of the S100 family, in human colorectal adenocarcinomas. Clin Cancer Res. 2000, 6(1); 172-177

Komatsu, K., Murata, K., Kameyama, M., Ayaki, M., Ishiguro, S., Miyoshi, J., Tatsuta, M., Inoue, M., Nakamura, H. Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases. Oncology. 2002m, 63(2); 192-200

Kominsky, S., Johnson, HM., Bryan, G., Tanabe, T., Hobeika, AC., Subramaniam, PS., Torres, B. IFNgamma inhibition of cell growth in glioblastomas correlates with increased level of the cyclin dependent kinase inhibitor p21WAF1/CIP1. Oncogene. 1998, 17(23); 2973-2979

Kondo, T., Minamino, N., Nagamura-Inoue, T., Matsumoto, M., Taniguchi, T., Tanaka, N. Identificaiton and charachterisation of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity. Oncogene. 1997, 15; 1275-1281

[page 128↓]

Kordowska, J., Stafford, WF., Wang, CL. Ca2+ and Zn2+ bind to different sites and induce different conformation changes in human calcyclin. Eur J Biochem. 1998, 253; 57-66

Kuchinke, W., Hart, RP., Jonakait, GM. Identification of mRNAs regulated by interferon-gamma in cultured rat astrocytes by PCR differential display. Neuroimmunomodulation. 1995, 2(6); 347-355

Kuznicki, J., Kordowska, J., Puzianowska, M., Wozniewicz, BM. Cacyclin as a marker of human epithelial cells and fibroblasts. Exp Cell Res. 1992, 200; 425-430

Lahusen, T., De Siervi, A., Kunick, C., Senderowicz, AM. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinog. 2003, 36; 183-194

Lang, P., Pardee , AB. Differential display of eukariotic messenger RNA by means of the polymerase chain reaction. Science. 1992, 257; 967-971

Langosch, D., Lindner, E., Gurezka, R. In vitro selection of self-interacting transmembrane segments-membrane proteins approached from a different perspective. IUBMB Life. 2002, 54(3); 109-113

Langston, A., Thomson, J., Gudas, L. Retinoic acid-resonsive enhancers located 3' of the HoxA and HoxB homeobox gene clusters. J Biol Chem. 1997, 272; 2167-2175

Lau, LF., Nathans, D. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J. 1985, 4(12); 3145-3151

Lee, EY., To, H., Shew, JY., Bookstein, R., Scully, P., Lee, WH. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science. 1988, 241; 218-221

Lee, SW., Tomasetto, C., Sager, R. Positive selection of candidate tumor-suppressor genes by substractive hybridization. Proc Natl Acad Sci USA. 1991, 88(7); 2825-2829

Levine, AJ. p53, the cellular gatekeeper for growth and division. Cell.1997, 88(3); 323-331

Li, X., Scuderi, A., Letsou, A., Vishup, DM. B56-Associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol Cell Biol. 2002, 22; 3674-3684

Lipsick, JS., Wang, DM. Transformation by v-Myb. Oncogene. 1999, 18; 3047-3055

Liu, TJ., el-Naggar, AK., McDonnell, TJ., Steck, KD., Wang, M., Taylor, DL., Clayman, GL. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res . 1995, 55(14); 3117-31122

Ma, J., Ptashne, M. A new class of yeast transcriptional activators. Cell. 1987, 5; 113-119

[page 129↓]

MacDonald, PN., Ong, DE. Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine. J Biol Chem. 1988, 263(25); 12478-12482

Madarressi, MH., Cameron, J., Taylor, KE., Wolfe, J. Identification and characterisation of a novel gene, TSGA10, expressed in testis. Gene. 2001, 262; 249-255

Maelandsmo, GM, Florenes, VA., Mellingsaeter, TE. Differential expression patterns of S100A2, S100A4, and S100A6 during progression of human malignant melanoma. Int J Cancer. 1997, 34; 464-469

Malik, S., Guermah, M., Roeder, RG. A dynamic model for PC4 coactivator function RNA polymerase II transcription. Proc. Natl. Acad. Sci. USA. 1998, 95; 2192-2197

Marshall, CJ. Tumor suppressor genes. Cell. 1991, 64(2); 313-326

McConnell, BB., Starborg, M., Brookes, S., Peters, G. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol. 1998, 8; 351-354

McCormick, F. Cancer gene therapy: fringe or cutting edge. Nat Rev Cancer. 1; 130-141

McCright, B., Rivers, AM., Scott, A., Virshup, DM. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem. 1996, 271; 22081-22089

Michalova, K., Kloucek, F., Musilova, J. Deletion of 13q in two patients with retinoblastoma, one probably due to 13q-mosaicism in the mother. Hum Genet. 1982, 61(3); 264-266

Michelson, S., Turowski, P., Picard, L., Goris, J., Landini, MP., Topilko, A., Hemmings, B., Bessia, C., Garcis, A., Virelizier, JL. Human cytomegalovirus carries serine/threonine protein phophatase PP1 and a host derived PP2A. J Virol. 1996, 70; 1415-1423

Millward, TA., Zolnierowisz, S., Hemmings, B. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci, 1999, 24; 186-191

Mondal, MS., Ruiz, A., Bok, D., Rando, R. Lecithin retinol acyltransferase contains cysteine residue essential for catalysis. Biochemistry. 2000, 39; 5215-5220

Mondal, MS., Ruiz, A., Hu, J., Bok, D., Rando, RR. Two histidine residues are essential for catalysis by lecithin retinol acyltrasnferase. FEBS Lett. 2001,489(1); 14-18

Moon, EY., Lerner, A. PDE4 inhibitors activate a mithochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A. Blood. 2003, 16;

Murata, K., Wu, J., Brautigan, DL. B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of the protein phosphatase 2A. Proc Natl Acad Sci USA. 1997, 94; 10624-10629

[page 130↓]

Murdoch JN., Hendelson, DJ., Doudney, K., Gaston-Massuet, C., Phillips HM., Paternotte, C., Artell, R., Stainier, P., Copp, AJ. Disruption of scribble (Scrib1) causes sever neural tube defects in the circletail mouse. Hum Mol Genet. 2003, 12; 87-98

Naar, AM., Boutin, JM., Lipkin, SM., Yu, VC., Holloway, JM., Glass, CK., Rosenfeld, MG. The orientation and spacing of core DNA-binding motifs dictate selestive transcriptional response to three nuclear receptors. Cell. 1991, 65; 1267-1279

Nakagawa, S., Huibregtse, JM. Human scribble (Vartul) is a target for ubiquitin-mediated degradation by the high-risk pappillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol. 2000, 20; 8244-8253

Nakagawa, K., Yokosawa, Y. Degradation of transcription factor IRF-1 by ubiquitin-proteasome pathway. Eur. J. Biochem, 2000, 267; 1680-1686

Nakayama, M., Kikuno, R., Ohara, O. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Genome Res. 2002, 12; 1773-1784

Naldini, A., Carney, DH., Pucci, A., Carraro, F. Human alpha-thrombin stimulates prolifiration of interferone-gamma differentiated, growth-arrested U937 cells, overcoming differentiation-related changes in expression of p21CIP1/WAF1 and cyclin D1. Cell Physiol. 2002, 191(3); 290-297

Neckers, L. Development of small molecule hsp90 inhibitors: utilizing both forward and revers chemical genomics for drug identification. Curr Med Chem . 2003, 10; 733-739

Niculescu, AB 3rd., Chen, X., Smeets, M., Hengst, L., Prives, C., Reed, SI. Effect of p21(Cip1/Waf1) at both G1/S and G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoredunplication. Mol Cell Biol. 1998, 18; 629-643

Nimmanapalli, R., O'Bryan, E., Kuhn, D., Yamaguchi, H., Wang, HG., Bhalla, KN. Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-xL., and Bax downstream of AAG-mediated downregulation of Akt, Raf-1, and Src kinases. Blood. 2003, ahead of print

Nozawa, H., Oda, E., Ueda, S., Tamura, G., Maesawa, C., Muto, T., Taniguchi, T., Tanaka, N. Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. Int. J. Cancer. 1998, 77; 522-527

Ogata, A., Nishimoto, N., Shima, Y., Yoshizaki, K., Kishimoto, T. Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction. Blood. 1994, 84; 3040-3046

Ouchi, T., Monteiro, AN., August, A., Aaronson, SA., Hanafusa, H. BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci USA. 1998; 95; 2302-2306

[page 131↓]

Ouchi, T., Lee, SW., Ouchi, M., Aaronson, SA., Horvath, CM. Collaboration of signal transduser and activtor of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc Natk Acad Sci USA. 2000, 97(10); 5208-5213

Pallas, DC., Shahrik, L., Martin, BL., Jaspers, S., Miller, TB., Brautigan, DL., Roberts, TM. Polyoma small t and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell. 1990, 60; 167-176

Pao, GM., Janknecht, R., Ruffner, H., Hunter, T., Verma, IM. CBP/p300 interact with and function as transcriptional coactivator or BRCA1. Proc Natl Acad Sci USA. 2000, 97; 1020-1025

Patton, SE., Martin, ML., Nelsen, LL., Fang, X., Mills, GB., Bast, RC., Ostrowski, MC. Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines. Cancer Research. 1998, 58; 2253-2259

Patturajan, M., Nomoto, S., Fomenkov, A., Hibi, K., Zangen, R., Poliak, N., Califano, J., Trink, B., Ratovitski, E., Sidransky, D. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell. 2002, 1; 369-379

Paulson, M., Pisharody, S., Pan, L., Guadagno, S., Mui, AL., Levy, DE. STAT protein transactivation domain recruit p300/CBP through widely divergent sequences. J Biol Chem. 1999, 274(36); 25343-25349

Pedrocchi, M., Schäfer, BW., Mueller, H. Expression of Ca2+ binding proteins of the S100 family in malignant human breast cancer cell lines and biopsy samples. Int J Cancer. 1994. 57, 684-690

Pestka, S., Langer, AJ., Zoon, K., Samuel, C. Interferons and their actions. Annu. Rev. Biochem. 1987. 56, 727-777

Pilgrim, S., Kolb-Maurer, A., Gentschev, I., Goebel, W., Kuhn, M. Deletion of the gene encoding p60 in Listeria monocytogenes leads to abnormal cell division and loss of actin based motility. Infect Immun. 2003. 71, 3473-3484

Pointing, CP., Aravind, L., Schultz, J., Bork, P., Koonin, EV. Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol. 1999. 289(4), 729-745

Rahman, N., Stratton, MR. The genetics of breast cancer susceptibility. Annu Rev Genet. 1998. 32, 95-121

Rajesh, D., Schnell, K., Verma, AK. Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis ny okadaic acid, an inhibitor of protein phosphatase 1 and 2A. Molecular pharmacology. 1999. 56, 515-525

[page 132↓]

Rashmi, R., Santhosh Kumar, TR., Karunagaran, D. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett. 2003. 538, 19-24

Roder, K., Latasa, MJ., Sul, HS. Silencing of the mouse H-rev107 gene encoding a class II tumor suppressor by CpG methylation. J Biol Chem. 2002. 277(34), 30543-30550

Rountree, MR., Bachman, KE., Baylin, SB. DMNT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex of replication foci. Nat Genet. 2000. 25, 269-277

Rubin, E., Mittnacht, S., Villa-Moruzzi, E., Ludlow, JW. Site-specific and temporally-regulated retinoblastoma protein dephophorylation by protein phosphatase type 1. Oncogene. 2001. 20(29), 3776-3785

Ruden, D.M., Ma, J., Li, Y., Wood, K., Ptashne, M. Generating yeast transcriptional activators containing no yeast protein sequences. Nature. 1991. 350, 250-251

Ruediger, R., Hentz, M., Fait, J., Mumby, M., Walter, G. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J Virol. 1994. 68, 123-129

Ruiz, A., Winston, A., Lim, YH., Gilbert, BA., Rando, R. Molecular and biochemical characterisation of Lecithin Retinol Acyltransferase. J Biol Chem. 1999. 274(6), 3834-3841

Russel, L., Finley, Jr., Brent, R. Interaction trap cloning with yeast. Oxford University Press. Gene Probes - a Practical Approach. Boston. 1998

Ryan, MD., Flint, M. Virus -encoded proteinases of the picornavirus super-group. Journal of General Virology. 1997. 78, 699-723

Sager, R. Genetic stratagies of tumor suppression. Am Rev Respir Dis. 1990. 142, 40-43

Sager, R. Expression genetic in cancer: Shifting the focus from DNA to RNA. Proc. Natl. Acad. Sci. USA. 1997. 94, 952-955

Sato, M., Taniguchi, T., Tanaka, N. The interferon system and interferon regulatory factor transcription factors - studies from gene knock-out mice. Cytokine Growth Factor Rev. 2001. 12, 133-142

Satoh, T., Nakafuku, M., Kaziro, Y. Function of Ras as a molecular switchin signal transduction. J Biol Chem. 1992. 267, 24149-24152

Satou, A., Taira, T., Iguchi-Ariga, SM., Ariga, H. A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. J Biol Chem. 2001. 276, 46562-46567

[page 133↓]

Schaefer, R., Iyver, J., Iten, E., Nirkko, AC. Partial reversion of the transformed phenotype in HRAS-trasnfected tumorigenic cells by trasnfer of a human gene. Proc Natl Acad Sci USA. 1988. 85, 1590-1594

Scheidtmann, KH., Mumby, MC., Rundell, K., Walter, G. Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Moll Cell Biol. 1991. 11, 1996-2003

Schindler, C., and Darnell, JE. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 1995. 64, 621-651

Schmiedeknecht, G., Kerkhoff, C., Orso, E., Stohr, J., Aslanidis, C., Nagy, GM., Knuechel, R., Schmitz, G. Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation. Eur J Biochem. 1996. 242(2), 339-351

Schwab, M. Amplification of the MYCN oncogene and deletion of putative tumour suppressor gene in human meuroblastomas. Hrsg.: Brain Pathol : Band 1990. 1, 41-46

Schwab, M. Hrsg.: Encyclopedic Reference of Cancer: Heidelberg Springer-Verlag Berlin, Heidelberg, New-York, 2001, S.3540665277, 992

Scott, MR., Westphal, KH., Rigby, PW. Activation of mouse genes in transformed cells. Cell. 1983. 34, 557-567

Scully, R., Chen. J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashey, T., Livingston, DM. Association of BRCA1 with Rad51 in mitotic and meotic cells. Cell. 1997. 88, 265-275

Seeling, JM., Miller, JR., Gil, R., Moon, RT., White, R., Vishup, DM. Regulation of of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science. 1999. 283, 2089-2091

Sers, C., Emmenegger, U., Husmann, K., Bucher, K., Andres, A., Schäfer, R. Growth -inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. J Cell Biol. 1997. 136(4), 935-944

Sers, C., Husmann, K., Nazarenko, I., Reich, S., Wiechen, K., Zhumabayeva, B., Adhikari, P., Schröder, K., Gontarewitcz, A., Schäfer, R. The class II tumour suppressor gene H-REV107-1 is a target of interferone-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. Oncogene. 2002. 21, 2829-2839

Shayesteh, L., Lu, Y., Kuo, WL., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, GB., Gray, JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet . 1999. 21, 99-102

[page 134↓]

Sheikh, MS., Li, XS., Chen, JC., Shao, ZM., Ordonez, JX., Fontana, JA. Mechanism of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene. 1994. 9(12), 3407-3415

Sherr, CJ. and McCormick, F. The RB and p53 pathways in cancer. Cancer Cell. 2002. 2, 103-112

Shima, H., Tohda, H., Aonuma, S., Nakayasu, M., DePaoli-Roach, AA., Sugimura, T., Nagao, M. Characterisation of the PP2A gene mutation in okadaic acid-resistant variants of CHO-K1 cells. Proc. Natl. Acad. Sci. USA. 1994. 91, 9267-9271

Shiohara, M., el-Deiry, WS., Wada, M., Nakamaki, T., Takeuchi, S., Yang, R., Chen, DL., Vogelstein, B., Koeffler, HP. Absence of WAF1 mutations in a variety of human malignancies. Blood. 1994. 84(11), 3781-3784

Shuai, K., Horvath, CM., Huang, LH., Qureshi, SA., Cowburn, D., Dasnell JE, Jr. Interferon activation of the transcriptional factor Stat91 involves dimerization through SH2-phophotyrosyl peptide interactions. Cell. 1994. 76(5), 821-828

Si, J., Collins, SJ. IL-3 - induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3 - dependent manner. Blood. 2002. 100, 4401-4409

Somasundaram, K., Zhang, H., Zeng, YX., Houvras, Y., Peng, Y., Zhang, H., Wu, GS., Licht, JD., Weber, BL., El-Deiry, W. Arrest of the cell cycle by the tumor-suppressor BRCA1 requires the CDK-inhibitor p21/WAF1/CIP1. Nature. 1997. 389, 187-190

Song, SY., Lee, SK., Kim, DH, Son, HJ, Kim, HJ., Lim, YJ., Lee, WY., Chun, HK., Rhee, JC. Expression of maspin in colon cancer: its relationship with p53 expression and microvessel density. Dig Dis Sci. 2002. 47, 1831-1835

Sontag, E., Sontag, JM., Garcia, A. Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t promote cell growth and NF-kappaB activation. EMBO J. 1997. 16, 5662-5671

Sontag, E. Protein phosphatase 2A: the Trojan Horse of cellular signalling. Cellular Signalling. 2000. 13, 7-16

Srivastava, S., Zou, ZQ., Pirollo, K., Blattner, W., Chang, EH. Germ-line transmission of a mutated p53 gene a cancer-prone family with Li-Fraumeni syndrome. Nature. 1990. 348, 747-749

Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Moroy, T., Bartek, J., Massague, J., Hanel, F., Eilers, M. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol. 2001. 3, 392-399

Stan, T., Brix, J., Schneider-Mergener, J., Pfanner, N., Neupert, W., Rapaport, D. Mitochondrial protein import: recognition of internal import signal of BCS1 by the TOM complex. Mol Cell Biol. 2003. 23(7), 2239-2250

[page 135↓]

Standaer, ML., Bandyopadhyay, G., Sajan, MP., Cong, L., Quon, MJ., Farese, RV. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. J Biol. Chem. 1999. 274, 14074-14078

Stark, GR., Kerr, IM., Williams, BR., SIlverman, RH., Schreiber, RD. How cells respond to interferons. Annu Rev Biochem. 1998. 67, 227-264

Strack, S. Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activation the MAP kinase (MAPK) cascade. J Biol Chem. 2002. 277, 41525-41532

Stulik, J., Österreicher, J., Koupilova, K., Knitek, J., Bures, J., Jadnik, P., Langr, F., Dedie, K., Schäfer, BW., Heinzmann, CW. Difeerential expression of the Ca2+ binding S100A6 protein in normal, preneoplastic and neoplastik colon mucosa. E J Cancer. 2000. 36, 1050-1059

Sugai, M., Fujiwara, T., Komatsuzawa, H., Suginaka, H. Identification and molecular characterization of a gene homologous to erp (endopeptidase resistance gene) in Staphylococcus aureus. Gene. 1998. 224, 67-75

[page 136↓]

Tamura, G., Ogasawara, S., Nishizuka, S., Maesawa, C., Suzuki, Y., Terashima, M., Saito, K., Satodate, R. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach. Cancer Res. 1996. 56, 612-615

Tan, RS., Taniguchi, T., Harada, H. Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1 and its possible role in tumor suppression. Cancer Res. 1996. 56(10), 2417-2421

Tanaka, N., and Taniguchi, T. The interferon regulatory factors and oncogenesis. Semin. Cancer Biol. 2000. 10, 73-81

Tanaka, N., Ishihara, M., Lamphier, MS., Nozawa, H., Matsuyama, T., Mak, TW., Aizawa, S., Tokino, T., Oren, M., Taniguchi, T. Cooperation of the tumor suppressors IRF-1 and p53 in response to DNA damage. Nature. 1996. 382, 816-818

Tirkonnen, M., Johannsson, O., Agnarsson, BA., Olsson, H., Igvarsson, S., Karhu, R., Tanner, M., Isola, J., Barkardottir, RB., Borg, A., Kallioniemi, OP. Distinct somatic genetic changes associated with tumor progression in carries of BRCA1 and BRCA2 germ-line mutations. Cancer Res. 1997. 57, 1222-1227

Tung, L., DeRocquigny, H., Zhao, LJ., Cayla, X., Roques, B., Ozon, R. Direct activation of protein phosphatase 2A0 by HIV-1 encoded protein complex Ncp7:vpr. FEBS. 1997. 401, 197-201

Um, SL., Lee, SY., Kim, EL., Han, HS., Koh, YM., Hong, KJ., Sin, HS., Park, JS. Antiproliferative mechnism of retinoid derivatives in ovarian cancer cells. Cancer Lett. 2001. 174, 127-134

Umekita, Y., Hiipakka, RA., Liao, S. Rat and human maspin: structures, metastatic suppressor activity and mutation in prostatic cancer cells. Cancer Lett. 1997. 113, 87-93

Veloso, M., Wrba, F., Kaserer, K., Heinze, G., Magalhaes, A., Herbst, F., Teleky, B. p53 gene status and expression of p53, mdm2, p21Waf1/Cip1 proteins in colorectal cancer. Virchows Arch. 2000. 437, 241-247

Venkitaraman, AR. Breast cancer genes and DNA repair. Science. 1999. 286, 100-102

Vojtek, AB., Hollenberg, SM. Ras-Raf interacrions: two-hybrid analysis. Methods Enzymol. 1995. 255, 331-342

Vojtek, AB., Hollenberg, SM., Cooper, JA. Mammalian Ras interacts directly with the serine/threonine kinase Raf.. Cell. 1993. 74, 205-214

Waldman, T., Kinzler, KW., Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 1995. 55, 5187-5190

[page 137↓]

Wang, SS., Esplin, ED., Li, JL., Huang, L., Gazdar, A., Minna, J., Evans, GA. Alteration of the PPP2R1B gene in human lung and colon cancer. Science. 1998. 284-287,

Wang, HG., PAthan, N., Ethell, IM., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Boto, T., Franke, TF., Reed, JC. Ca 2+ - induced apoptosis through calcineurin dephophorylation of BAD. Science. 1999. 284, 339-343

Wang, Q., Zhang, H., Fishel, R., Green, MI. BRCA1 and cell signallling. Oncogene. 2000. 19, 6152-6158

Wang, JY. Negative regulation of c-abl tyrosine kinase by its N-terminal amino acids. Oncogene Res. 1988. 3, 293-298

Weber, BL. Familial breast cancer. Recent Results Cancer Res. 1996. 140, 5-16

Weger, S., Wendland, M., Kleinschmidt, J., Helbronn, R. The adeno-associated virus type 2 regulatory proteins Rep78 and Rep68 interact with the transcriptional coactivator PC4. J Virol. 1999. 73(1), 260-269

Weger, S., Wendland, M., Kleinschmidt, JA., Heilbronn, R. The adeno-associated virus type 2 regulatory proteins Rep78 and Rep68 interact with the transcriptional coactivator PC4. Journal of virology. 1999. 73, 260-269

Weinberg, RA. Tumor suppressor genes. Science. 1991. 254, 1138-1146

Wen, HC., Huahg, WC., Ali, A., Woodgett, JR., Lin, WW. Negative regualtion of phosphatidylinositol 3-kinase and Akt signaling pathway by PKC. Cellular Signalling. 2002. 15, 37-45

Wendy, HR., Han, M. The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis. Developmental Biology. 2002. 241, 247-258

Weterman, MA., Stoopen, GM., van Muijen, GN., Kuznicki, J., Ruiter, DR., Bloemers, HP. Expression of calcyclin in human melanoma cell lines correlated with metastatic behavior in nude mice. Cancer Res. 1992. 52, 1291-1296

Willman, CL., Sever, CE., Pallavicini, MG., Harada, H., Tanaka, N., Slovak, ML., YAmamoto, H., Harada, K., Meeker, TC., List, AF., Taniguchi, T. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science. 1993. 259, 968-971

[page 138↓]

Windbichler, GH., Hausmaninger, H., Stummvoll, W., Graf, AH., Kainz, C., Lahojny, J., Denison, U., Muller-Holzner, E., Marth, C. Intereron-gamma in the first-line therapy of ovarian cancer:a randomizer phase III trial. Br J Cancer. 2000. 82(6), 1138-1144

Wu, SY., Chiang, CM. Propterties of PC4 and RNA polymerase II complex in directing activated and basal transcription. J Biol Chem. 1998. 273(20), 12492-12498

Wu, S., Zhang, D., Zhang, ZP., Soprano, DR., Soprano, KJ. Critical role of both retinoic nuclear receptors and retinoic-X-receptors in mediating gorwth inhibition of ovarian cancer cells by all-trans retinoic acid. Oncogone. 1998. 17, 2839-2849

Wz, Q., Zhang, M., Liu, S., Chen, Y., Su, W. Retioic acid receptor beta is required for anti-activator protein-1 activity by retinoic acid in gastric cancer cells. Chin Med J (Engl. 2002. 115(6), 810-814

Xu, X., Weaver, Z., Linke, SP., Li, C., Gotay, J., Wang, XW., Harris, CC., Ried, T., Deng, CX. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999. 3, 389-395

Xu, B., Kim, S., Kastan, MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 2001. 21, 3445-3450

Yaginuma, Y., Westphal, H. Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res. 1992. 52(15), 4196-4199

Yang, Q., Sakurai, T., Kakudo, K. Retinoid, retinoic acid receptor beta and breast cancer. Breast Cancer Res Treat. 2002. 76(2), 167-173

Yang-Yen, HF., Zhang, XK., Graupner, G., Tzukerman, M., Sakamoto, B., KArin, M., Pfahl, M. Antagonism between retinoic acid receptor and AP-1: implications for tumor promotion and inflamation. New Biol. 1991. 3(12), 1206-1219

Yellaturu, CR., Bhanoor, M., Neeli, I., Rao, G. N-ethylmaleimide inhibitis platelet-derived growth factor BB-stimulated Akt phosphorylation via activaion of protein phosphatase 2A. J Biol Chem. 2002. 277, 40148-40155

Yu, VPCC., Koehler, M., Steinlein, C., Schmidt, M., Hanakahi, L., van Gool, A., West, SC., Venkitaraman, AR. Gross chromosomal rearrangments and genetic exchange beween non-homologous chromosomes following BRCA2 inactivation. Genes Dev. 2000. 14, 1400-1406

Yuan, ZQ., Sun, M., Feldman, RI., Wang, G., Ma, X., Jiang, C., Coppola, D., Nicosia, AV., Cheng, JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kunase/Akt pathway in human ovarian cancer. Oncogene. 2000. 19, 2324-2330

[page 139↓]

Zakany, R., Szucs, K., Bako, E., Felszeghy, S., Czifra, G., Biro, T., Modis, L., Gergely, P. Protein phosphatase 2 A is involved in the regulation of protein kinase A signaling during in vitro chondrogenesis. Exp Cell Res. 2002. 275, 1-8

Zeilmann, L., Sirim, P., Kremmer, E., Kolanus, W. Cloning of ACP33 as a noval intracellular ligand of CD4. J BIol Chem. 2001. 276, 9123-9232

Zhang, XK., Lehmann, J., Hoffmann, B., Dawson, M., Cameron, J., Graupner, G., Hermann, T., Tran, P., Pfahl, M. Retinoid X receptor is an auxilliary protein for thyroid hormone and retinoid acids receptors. Nature. 1992. 355, 441-446

Zhang, D., Holmes, WF., Wu, S., Soprano, DR., Soprano, KJ. Retinoids and ovarian cancer. Journal of cellular physiology. 2000. 185, 1-20

Zhou, B., Wang, ZX., Zhao, Y., Brautigan, DL., Zhang, ZY. The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem. 2002. 277, 31818-31825

Zhou, J., Pham, HT., Ruediger, R., Walter, G. Charachterisation of the Aalpha and Abeta subunit isoformes of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Biochem J. 2003. 369, 387-398

Zimmermann, KC., Bonzon, C., Green, DR. The machinery of programmed cell death. Pharmacol Ther. 2001. 92(1), 57-70

Zou, Z., Anisowicz, A., Hendrix, MJ., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Sertor, E., Sager, R. MAspin, a serpin with tumor-suppressive activity in human mammary epithelial cells. Science. 1994. 263, 526-529

Zou, Z., Gao, C., Nagaich, AK., Connell, T., Saito, S., Moul, JW., Seth, P., Appella, E., Srivastlava, S. P53 regulates the expression of the tumor suppressor gene maspin. J Biol Chem. 2000. 275(9), 6051-6054

Zuber, J., Tchernitsa, OI., Hinzmann, B., Schmitz, A-C., Grips, M., Hellrigel, M., Sers, C., Rosenthal, A., Schäfer, R. A genome-wide survey of RAS-transformation targets. Nat. Genet. 2000. 24, 144-152

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 3.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML generated: