Proteom-Analyse von chemo- und thermoresistenten Magen- und Pankreaskarzinomzellinien zur Untersuchung von thermoresistenzassoziierten Phänomenen und Interaktionen mit ChemoresistenzJulia Poland 1.11.1.1.2.21.2.1.1.2.2.31.2.2.1.1.2.2.2.41.3.1.3.1.51.3.2.61.3.3.71.4.891.5.1.5.1.176#1751.5.2.10318#2221.5.3.111.6.1.6.1.121.6.2.131.7.152.162.1.2.1.1.172.1.2.2.1.3.182.1.3.1.2.2.192.2.1.2.2.1.1.2.2.1.2.202.2.1.3.212.2.1.4.222.2.1.5.2.2.1.6.232.2.1.7.242.2.1.8.25262.2.2.2.2.2.1.2.2.2.2.27282.2.2.3.2930530#3022.2.2.4.312.2.3.2.2.4.32709#4303.333.1.291#293343.2.353.2.1.36613#83737383.2.2.393.2.2.1.40734#5593.2.2.2.4142782#596433.2.2.3.44774#5883.2.3.453.2.3.1.46766#5843.2.3.2.4748790#6013.2.3.3.4950790#6013.2.4.5152534.544.1.4.1.1.4.1.2.554.1.3.4.1.4.56574.2.584.2.1.4.2.2.594.2.2.1.60 HSP27616263HSP706465HSP90664.2.2.2.67CalnexinCalreticulinBIP68Reticulocalbin694.2.2.3.704.2.2.4.4.2.2.5.714.2.2.6.72734.2.2.7.4.2.3.744.2.3.1.75764.2.3.2.4.2.4.4.2.4.1.77784.2.4.2.4.2.5.79804.2.6.815.8283 6. Literatur848586878889909192939495AnhangAbkürzungenDanksagungLebenslaufErklärung an Eides StattdeInhaltsverzeichnisHilfe 6. Literatur 1. Ahluwalia, A.; Newbold, P.; Brain, S. D. und Flower, R. J. (1995): Topical glucocorticoids inhibit neurogenic inflammation: involvement of lipocortin 1, Eur J Pharmacol 283) [1-3], Seite 193-8.. 2. Aitken, A.; Howell, S.; Jones, D.; Madrazo, J. und Patel, Y. (1995): 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF, J Biol Chem 270) [11], Seite 5706-9.. 3. Anderson, J. M.; Heindl, L. M.; Bauman, P. A.; Ludi, C. W.; Dalton, W. S. und Cress, A. E. (1996): Cytokeratin expression results in a drug-resistant phenotype to six different chemotherapeutic agents, Clin Cancer Res 2) [1], Seite 97-105.. http://aacr.edoc.com/ccr/v2n1/df000097.html 4. Anderson, N. G. und Anderson, L. (1982): The Human Protein Index, Clin Chem 28) [4 Pt 2], Seite 739-48.. 5. Appel, R. D.; Sanchez, J. C.; Bairoch, A.; Golaz, O.; Ravier, F.; Pasquali, C.; Hughes, G. J. und Hochstrasser, D. F. (1996): The SWISS-2DPAGE database of two-dimensional polyacrylamide gel electrophoresis, its status in 1995, Nucleic Acids Res 24) [1], Seite 180-1.. http://www.oup.co.uk/nar/Volume_24/Issue_01/5s1043_gml.abs.html 6. Appelbaum, F. R.; Fisher, L. D. und Thomas, E. D. (1988): Chemotherapy v marrow transplantation for adults with acute nonlymphocytic leukemia: a five-year follow-up, Blood 72) [1], Seite 179-84.. 7. Arrigo, A. P. (1998): Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death, Biol Chem 379) [1], Seite 19-26.. 8. Aubel-Sadron, G. und Londos-Gagliardi, D. (1984): Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review, Biochimie 66) [5], Seite 333-52. 9. Bader, B. L.; Magin, T. M.; Hatzfeld, M. und Franke, W. W. (1986): Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein, Embo J 5) [8], Seite 1865-75. 10. Bauman, P. A.; Dalton, W. S.; Anderson, J. M. und Cress, A. E. (1994): Expression of cytokeratin confers multiple drug resistance, Proc Natl Acad Sci U S A 91) [12], Seite 5311-4.. 11. Becker, J.; Mezger, V.; Courgeon, A. M. und Best-Belpomme, M. (1991): On the mechanism of action of H2O2 in the cellular stress, Free Radic Res Commun 12-13) [Pt 1], Seite 455-60.. 12. Berhane, K.; Hao, X. Y.; Egyhazi, S.; Hansson, J.; Ringborg, U. und Mannervik, B. (1993): Contribution of glutathione transferase M3-3 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line, Cancer Res 53) [18], Seite 4257-61. 13. Bichat, F.; Mouawad, R.; Solis-Recendez, G.; Khayat, D. und Bastian, G. (1997): Cytoskeleton alteration in MCF7R cells, a multidrug resistant human breast cancer cell line, Anticancer Res 17) [5A], Seite 3393-401.. 14. Bjellqvist, B.; Ek, K.; Righetti, P. G.; Gianazza, E.; Gorg, A.; Westermeier, R. und Postel, W. (1982): Isoelectric focusing in immobilized pH gradients: principle, methodology and some applications, J Biochem Biophys Methods 6) [4], Seite 317-39.. 15. Bogovic, J.; Douwes, F.R. und Douwes, O. (1999): Die Hyperthermie unter besonderer Berücksichtigung der extremen Ganzkörper-Hyperthermie (GHT) 3, AKODH-INTERN, SynMed Verlag,

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