<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Neue Ansätze zur zielgerichteten Behandlung solider Tumoren.Antisense Oligonukleotide und Immunotoxine zur
tumorzellspezifischen Apoptoseinduktion</cms:entry><cms:entry type="author">Maximilian Posch</cms:entry><cms:entry id="N1002C" part="front" ref="N1002C" type="pagenumber">2</cms:entry><cms:entry id="N10057" part="front" ref="N10057" type="pagenumber">3</cms:entry><cms:entry id="N10063" part="front" ref="N10063" type="pagenumber">4</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="_Einleitung" part="chapter1" ref="_Einleitung" type="link"/><cms:entry id="N10070" part="chapter1" ref="N10070" type="pagenumber">8</cms:entry><cms:entry id="N10074" part="chapter1" ref="N10074" type="section">1.1</cms:entry><cms:entry id="N1008D" part="chapter1" ref="N1008D" type="pagenumber">9</cms:entry><cms:entry id="N1009A" part="chapter1" ref="N1009A" type="section">1.2</cms:entry><cms:entry id="N1009D" part="chapter1" ref="N1009D" type="subsection">1.2.1</cms:entry><cms:entry id="N100A6" part="chapter1" ref="N100A6" type="pagenumber">10</cms:entry><cms:entry id="N100AD" part="chapter1" ref="N100AD" type="subsection">1.2.2</cms:entry><cms:entry id="N100B3" part="chapter1" ref="N100B3" type="pagenumber">11</cms:entry><cms:entry id="N100B7" part="chapter1" ref="N100B7" type="subsection">1.2.3</cms:entry><cms:entry id="N100BD" part="chapter1" ref="N100BD" type="subsection">1.2.4</cms:entry><cms:entry id="N100C6" part="chapter1" ref="N100C6" type="pagenumber">12</cms:entry><cms:entry id="N100CD" part="chapter1" ref="N100CD" type="section">1.3</cms:entry><cms:entry id="N100D6" part="chapter1" ref="N100D6" type="pagenumber">13</cms:entry><cms:entry id="N100E0" part="chapter1" ref="N100E0" type="subsection">1.3.1</cms:entry><cms:entry id="N100E9" part="chapter1" ref="N100E9" type="pagenumber">14</cms:entry><cms:entry id="N100F6" part="chapter1" ref="N100F6" type="pagenumber">15</cms:entry><cms:entry id="N100FA" part="chapter1" ref="N100FA" type="subsection">1.3.2</cms:entry><cms:entry id="N10103" part="chapter1" ref="N10103" type="subsection">1.3.3</cms:entry><cms:entry id="N1010C" part="chapter1" ref="N1010C" type="pagenumber">16</cms:entry><cms:entry id="N10113" part="chapter1" ref="N10113" type="mm"/><cms:entry id="N1011A" part="chapter1" ref="N1011A" type="section">1.4</cms:entry><cms:entry id="N1011D" part="chapter1" ref="N1011D" type="subsection">1.4.1</cms:entry><cms:entry id="N10126" part="chapter1" ref="N10126" type="pagenumber">17</cms:entry><cms:entry id="N1012A" part="chapter1" ref="N1012A" type="block">1.4.1.1</cms:entry><cms:entry id="N10133" part="chapter1" ref="N10133" type="mm"/><cms:entry id="N1013D" part="chapter1" ref="N1013D" type="block">1.4.1.2</cms:entry><cms:entry id="N10143" part="chapter1" ref="N10143" type="pagenumber">18</cms:entry><cms:entry id="N10147" part="chapter1" ref="N10147" type="block">1.4.1.3</cms:entry><cms:entry id="N10156" part="chapter1" ref="N10156" type="subsection">1.4.2</cms:entry><cms:entry id="N1015C" part="chapter1" ref="N1015C" type="pagenumber">19</cms:entry><cms:entry id="N10160" part="chapter1" ref="N10160" type="block">1.4.2.1</cms:entry><cms:entry id="N1016C" part="chapter1" ref="N1016C" type="block">1.4.2.2</cms:entry><cms:entry id="N10172" part="chapter1" ref="N10172" type="block">1.4.2.3</cms:entry><cms:entry id="N10175" part="chapter1" ref="N10175" type="pagenumber">20</cms:entry><cms:entry id="N1017F" part="chapter1" ref="N1017F" type="mm"/><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N1018F" part="chapter2" ref="N1018F" type="pagenumber">21</cms:entry><cms:entry id="N10193" part="chapter2" ref="N10193" type="section">2.1</cms:entry><cms:entry id="N10199" part="chapter2" ref="N10199" type="table"/><cms:entry id="N10287" part="chapter2" ref="N10287" type="section">2.2</cms:entry><cms:entry id="N1028D" part="chapter2" ref="N1028D" type="table"/><cms:entry id="N104F8" part="chapter2" ref="N104F8" type="pagenumber">22</cms:entry><cms:entry id="N10526" part="chapter2" ref="N10526" type="table"/><cms:entry id="N105C3" part="chapter2" ref="N105C3" type="table"/><cms:entry id="N1060C" part="chapter2" ref="N1060C" type="table"/><cms:entry id="N106F7" part="chapter2" ref="N106F7" type="section">2.3</cms:entry><cms:entry id="N106FA" part="chapter2" ref="N106FA" type="subsection">2.3.1</cms:entry><cms:entry id="N10703" part="chapter2" ref="N10703" type="pagenumber">23</cms:entry><cms:entry id="N10707" part="chapter2" ref="N10707" type="subsection">2.3.2</cms:entry><cms:entry id="N10711" part="chapter2" ref="N10711" type="subsection">2.3.3</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N1071D" part="chapter3" ref="N1071D" type="pagenumber">24</cms:entry><cms:entry id="N10721" part="chapter3" ref="N10721" type="section">3.1</cms:entry><cms:entry id="N10724" part="chapter3" ref="N10724" type="subsection">3.1.1</cms:entry><cms:entry id="N1072A" part="chapter3" ref="N1072A" type="subsection">3.1.2</cms:entry><cms:entry id="N10730" part="chapter3" ref="N10730" type="subsection">3.1.3</cms:entry><cms:entry id="N1073F" part="chapter3" ref="N1073F" type="subsection">3.1.4</cms:entry><cms:entry id="N10742" part="chapter3" ref="N10742" type="pagenumber">25</cms:entry><cms:entry id="N10749" part="chapter3" ref="N10749" type="subsection">3.1.5</cms:entry><cms:entry id="N1074F" part="chapter3" ref="N1074F" type="subsection">3.1.6</cms:entry><cms:entry id="N10755" part="chapter3" ref="N10755" type="subsection">3.1.7</cms:entry><cms:entry id="N1075B" part="chapter3" ref="N1075B" type="subsection">3.1.8</cms:entry><cms:entry id="N1075E" part="chapter3" ref="N1075E" type="pagenumber">26</cms:entry><cms:entry id="N10765" part="chapter3" ref="N10765" type="block">3.1.8.1</cms:entry><cms:entry id="N1076B" part="chapter3" ref="N1076B" type="block">3.1.8.2</cms:entry><cms:entry id="N10771" part="chapter3" ref="N10771" type="subsection">3.1.9</cms:entry><cms:entry id="N10777" part="chapter3" ref="N10777" type="pagenumber">27</cms:entry><cms:entry id="N1077E" part="chapter3" ref="N1077E" type="subsection">3.1.10</cms:entry><cms:entry id="N10787" part="chapter3" ref="N10787" type="subsection">3.1.11</cms:entry><cms:entry id="N1078D" part="chapter3" ref="N1078D" type="section">3.2</cms:entry><cms:entry id="N10790" part="chapter3" ref="N10790" type="pagenumber">28</cms:entry><cms:entry id="N10794" part="chapter3" ref="N10794" type="subsection">3.2.1</cms:entry><cms:entry id="N1079A" part="chapter3" ref="N1079A" type="subsection">3.2.2</cms:entry><cms:entry id="N107A0" part="chapter3" ref="N107A0" type="subsection">3.2.3</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N107A9" part="chapter4" ref="N107A9" type="pagenumber">29</cms:entry><cms:entry id="N107AD" part="chapter4" ref="N107AD" type="section">4.1</cms:entry><cms:entry id="N107B0" part="chapter4" ref="N107B0" type="subsection">4.1.1</cms:entry><cms:entry id="N107B3" part="chapter4" ref="N107B3" type="block">4.1.1.1</cms:entry><cms:entry id="N107BC" part="chapter4" ref="N107BC" type="mm"/><cms:entry id="N107CE" part="chapter4" ref="N107CE" type="mm"/><cms:entry id="N107D8" part="chapter4" ref="N107D8" type="pagenumber">30</cms:entry><cms:entry id="N107DC" part="chapter4" ref="N107DC" type="block">4.1.1.2</cms:entry><cms:entry id="N107E5" part="chapter4" ref="N107E5" type="mm"/><cms:entry id="N107EF" part="chapter4" ref="N107EF" type="block">4.1.1.3</cms:entry><cms:entry id="N107F5" part="chapter4" ref="N107F5" type="pagenumber">31</cms:entry><cms:entry id="N107FF" part="chapter4" ref="N107FF" type="mm"/><cms:entry id="N10809" part="chapter4" ref="N10809" type="subsection">4.1.2</cms:entry><cms:entry id="N1080F" part="chapter4" ref="N1080F" type="pagenumber">32</cms:entry><cms:entry id="N10816" part="chapter4" ref="N10816" type="block">4.1.2.1</cms:entry><cms:entry id="N1081F" part="chapter4" ref="N1081F" type="mm"/><cms:entry id="N1082F" part="chapter4" ref="N1082F" type="pagenumber">33</cms:entry><cms:entry id="N10833" part="chapter4" ref="N10833" type="block">4.1.2.2</cms:entry><cms:entry id="N1083F" part="chapter4" ref="N1083F" type="mm"/><cms:entry id="N1084C" part="chapter4" ref="N1084C" type="subsection">4.1.3</cms:entry><cms:entry id="N1084F" part="chapter4" ref="N1084F" type="pagenumber">34</cms:entry><cms:entry id="N10859" part="chapter4" ref="N10859" type="table"/><cms:entry id="N108F5" part="chapter4" ref="N108F5" type="table"/><cms:entry id="N10966" part="chapter4" ref="N10966" type="block">4.1.3.1</cms:entry><cms:entry id="N1096C" part="chapter4" ref="N1096C" type="mm"/><cms:entry id="N1097C" part="chapter4" ref="N1097C" type="pagenumber">35</cms:entry><cms:entry id="N10980" part="chapter4" ref="N10980" type="block">4.1.3.2</cms:entry><cms:entry id="N10989" part="chapter4" ref="N10989" type="mm"/><cms:entry id="N10999" part="chapter4" ref="N10999" type="pagenumber">36</cms:entry><cms:entry id="N1099D" part="chapter4" ref="N1099D" type="mm"/><cms:entry id="N109AD" part="chapter4" ref="N109AD" type="block">4.1.3.3</cms:entry><cms:entry id="N109B0" part="chapter4" ref="N109B0" type="pagenumber">37</cms:entry><cms:entry id="N109C6" part="chapter4" ref="N109C6" type="pagenumber">38</cms:entry><cms:entry id="N109CA" part="chapter4" ref="N109CA" type="mm"/><cms:entry id="N109D4" part="chapter4" ref="N109D4" type="section">4.2</cms:entry><cms:entry id="N109DD" part="chapter4" ref="N109DD" type="pagenumber">39</cms:entry><cms:entry id="N109E4" part="chapter4" ref="N109E4" type="subsection">4.2.1</cms:entry><cms:entry id="N109EA" part="chapter4" ref="N109EA" type="block">4.2.1.1</cms:entry><cms:entry id="N109F6" part="chapter4" ref="N109F6" type="pagenumber">40</cms:entry><cms:entry id="N109FA" part="chapter4" ref="N109FA" type="mm"/><cms:entry id="N10A0A" part="chapter4" ref="N10A0A" type="block">4.2.1.2</cms:entry><cms:entry id="N10A13" part="chapter4" ref="N10A13" type="pagenumber">41</cms:entry><cms:entry id="N10A17" part="chapter4" ref="N10A17" type="mm"/><cms:entry id="N10A24" part="chapter4" ref="N10A24" type="subsection">4.2.2</cms:entry><cms:entry id="N10A2A" part="chapter4" ref="N10A2A" type="block">4.2.2.1</cms:entry><cms:entry id="N10A30" part="chapter4" ref="N10A30" type="pagenumber">42</cms:entry><cms:entry id="N10A37" part="chapter4" ref="N10A37" type="mm"/><cms:entry id="N10A41" part="chapter4" ref="N10A41" type="block">4.2.2.2</cms:entry><cms:entry id="N10A4A" part="chapter4" ref="N10A4A" type="pagenumber">43</cms:entry><cms:entry id="N10A54" part="chapter4" ref="N10A54" type="mm"/><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N10A64" part="chapter5" ref="N10A64" type="pagenumber">44</cms:entry><cms:entry id="N10A68" part="chapter5" ref="N10A68" type="section">5.1</cms:entry><cms:entry id="N10A6B" part="chapter5" ref="N10A6B" type="subsection">5.1.1</cms:entry><cms:entry id="N10A74" part="chapter5" ref="N10A74" type="mm"/><cms:entry id="N10A7B" part="chapter5" ref="N10A7B" type="subsection">5.1.2</cms:entry><cms:entry id="N10A84" part="chapter5" ref="N10A84" type="pagenumber">45</cms:entry><cms:entry id="N10A88" part="chapter5" ref="N10A88" type="mm"/><cms:entry id="N10A92" part="chapter5" ref="N10A92" type="subsection">5.1.3</cms:entry><cms:entry id="N10A9B" part="chapter5" ref="N10A9B" type="pagenumber">46</cms:entry><cms:entry id="N10A9F" part="chapter5" ref="N10A9F" type="mm"/><cms:entry id="N10AAC" part="chapter5" ref="N10AAC" type="subsection">5.1.4</cms:entry><cms:entry id="N10AB5" part="chapter5" ref="N10AB5" type="pagenumber">47</cms:entry><cms:entry id="N10AB9" part="chapter5" ref="N10AB9" type="mm"/><cms:entry id="N10AC3" part="chapter5" ref="N10AC3" type="section">5.2</cms:entry><cms:entry id="N10ACF" part="chapter5" ref="N10ACF" type="subsection">5.2.1</cms:entry><cms:entry id="N10AD5" part="chapter5" ref="N10AD5" type="pagenumber">48</cms:entry><cms:entry id="N10ADF" part="chapter5" ref="N10ADF" type="mm"/><cms:entry id="N10AEF" part="chapter5" ref="N10AEF" type="subsection">5.2.2</cms:entry><cms:entry id="N10AF5" part="chapter5" ref="N10AF5" type="pagenumber">49</cms:entry><cms:entry id="N10B08" part="chapter5" ref="N10B08" type="pagenumber">50</cms:entry><cms:entry id="N10B0C" part="chapter5" ref="N10B0C" type="mm"/><cms:entry id="chapter6" part="chapter6" ref="chapter6" type="chapter">6</cms:entry><cms:entry id="N10B19" part="chapter6" ref="N10B19" type="pagenumber">51</cms:entry><cms:entry id="N10B23" part="chapter6" ref="N10B23" type="section">6.1</cms:entry><cms:entry id="N10B2F" part="chapter6" ref="N10B2F" type="pagenumber">52</cms:entry><cms:entry id="N10B3C" part="chapter6" ref="N10B3C" type="pagenumber">53</cms:entry><cms:entry id="N10B52" part="chapter6" ref="N10B52" type="pagenumber">54</cms:entry><cms:entry id="N10B5F" part="chapter6" ref="N10B5F" type="pagenumber">55</cms:entry><cms:entry id="N10B66" part="chapter6" ref="N10B66" type="section">6.2</cms:entry><cms:entry id="N10B7B" part="chapter6" ref="N10B7B" type="pagenumber">56</cms:entry><cms:entry id="N10B8B" part="chapter6" ref="N10B8B" type="pagenumber">57</cms:entry><cms:entry id="N10B95" part="N10B95" ref="N10B95" type="abbreviation">
            
Abkürzungen:</cms:entry><cms:entry id="N10B99" part="N10B95" ref="N10B99" type="pagenumber">7</cms:entry><cms:entry id="N10BA0" part="N10B95" ref="N10BA0" type="table"/><cms:entry id="N10F80" part="N10F80" ref="N10F80" type="bibliography">
            
Referenzen</cms:entry><cms:entry id="N10F84" part="N10F80" ref="N10F84" type="pagenumber">58</cms:entry><cms:entry id="N11110" part="N10F80" ref="N11110" type="pagenumber">59</cms:entry><cms:entry id="N112FC" part="N10F80" ref="N112FC" type="pagenumber">60</cms:entry><cms:entry id="N114FF" part="N10F80" ref="N114FF" type="pagenumber">61</cms:entry><cms:entry id="N11686" part="N10F80" ref="N11686" type="pagenumber">62</cms:entry><cms:entry ref="N117BE" type="acknowledgement">
            
         </cms:entry><cms:entry ref="N117C2" type="pagenumber">63</cms:entry><cms:entry id="N117EF" part="N117EF" ref="N117EF" type="vita">
            
Lebenslauf von Maximilian Posch</cms:entry><cms:entry id="N117F3" part="N117EF" ref="N117F3" type="pagenumber">64</cms:entry><cms:entry id="N1183E" part="N1183E" ref="N1183E" type="appendix">
            
Veröffentlichungen:</cms:entry><cms:entry id="N11842" part="N1183E" ref="N11842" type="pagenumber">65</cms:entry><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><acknowledgement id="N117BE">
         <head>
            <pagenumber id="N117C2" label="63" numbering="arabic" start="63"/>
         </head>
         <p>Mein Dank geht insbesondere an die Mitarbeiter des</p>
         <p>Forschungslabor für Onkologie, des Dept. Innere Medizin am</p>
         <p>Universitätsspital in Zürich für ihre herzliche Aufnahme,</p>
         <p>Kollegialität und hervorragende Zusammenarbeit.</p>
         <p>Dr. Robert Olie, Dr. Claudio Di Paolo, Dr. Oliver Gautschi, Jürg</p>
         <p>Sigrist, Dr. Annemarie Ziegler, Dr. Sally Donaldson, Dr. Andreas</p>
         <p>Trojan, Dr. Bernhard Odermatt, Dr. Jörg Hummerjohan, Dr. Sian</p>
         <p>Leech, Dr. Dominique Tschudi, Dr. Paula Simoes-Wüst, Brigitte</p>
         <p>Sigrist, Florian Baumann, Martina Müller, Thomas Schürpf,</p>
         <p>Bettina Baumann, Renzo Küttel, Birgit Hofer, Prof. Dr. Rolf Stahel</p>
         <p>und PD Dr. Uwe Zangemeister-Wittke</p>
         <p>des weiteren bedanke ich mich bei Dr. Elena Elstner und Prof. Dr.</p>
         <p>Possinger für ihre Unterstützung</p>
      </acknowledgement></cms:content></cms:document></cms:container>