<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Neue Ansätze zur zielgerichteten Behandlung solider Tumoren.Antisense Oligonukleotide und Immunotoxine zur
tumorzellspezifischen Apoptoseinduktion</cms:entry><cms:entry type="author">Maximilian Posch</cms:entry><cms:entry id="N1002C" part="front" ref="N1002C" type="pagenumber">2</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="_Einleitung" part="chapter1" ref="_Einleitung" type="link"/><cms:entry id="N1005F" part="chapter1" ref="N1005F" type="pagenumber">8</cms:entry><cms:entry id="N10064" part="chapter1" ref="N10064" type="section">1.1</cms:entry><cms:entry id="N1007E" part="chapter1" ref="N1007E" type="pagenumber">9</cms:entry><cms:entry id="N1008D" part="chapter1" ref="N1008D" type="section">1.2</cms:entry><cms:entry id="N10092" part="chapter1" ref="N10092" type="subsection">1.2.1</cms:entry><cms:entry id="N1009C" part="chapter1" ref="N1009C" type="pagenumber">10</cms:entry><cms:entry id="N100A5" part="chapter1" ref="N100A5" type="subsection">1.2.2</cms:entry><cms:entry id="N100AC" part="chapter1" ref="N100AC" type="pagenumber">11</cms:entry><cms:entry id="N100B2" part="chapter1" ref="N100B2" type="subsection">1.2.3</cms:entry><cms:entry id="N100BB" part="chapter1" ref="N100BB" type="subsection">1.2.4</cms:entry><cms:entry id="N100C5" part="chapter1" ref="N100C5" type="pagenumber">12</cms:entry><cms:entry id="N100CF" part="chapter1" ref="N100CF" type="section">1.3</cms:entry><cms:entry id="N100D9" part="chapter1" ref="N100D9" type="pagenumber">13</cms:entry><cms:entry id="N100E4" part="chapter1" ref="N100E4" type="subsection">1.3.1</cms:entry><cms:entry id="N100EE" part="chapter1" ref="N100EE" type="pagenumber">14</cms:entry><cms:entry id="N100FB" part="chapter1" ref="N100FB" type="pagenumber">15</cms:entry><cms:entry id="N10101" part="chapter1" ref="N10101" type="subsection">1.3.2</cms:entry><cms:entry id="N1010D" part="chapter1" ref="N1010D" type="subsection">1.3.3</cms:entry><cms:entry id="N10117" part="chapter1" ref="N10117" type="pagenumber">16</cms:entry><cms:entry id="N1011E" part="chapter1" ref="N1011E" type="mm"/><cms:entry id="N10128" part="chapter1" ref="N10128" type="section">1.4</cms:entry><cms:entry id="N1012D" part="chapter1" ref="N1012D" type="subsection">1.4.1</cms:entry><cms:entry id="N10137" part="chapter1" ref="N10137" type="pagenumber">17</cms:entry><cms:entry id="N1013C" part="chapter1" ref="N1013C" type="block">1.4.1.1</cms:entry><cms:entry id="N10146" part="chapter1" ref="N10146" type="mm"/><cms:entry id="N10152" part="chapter1" ref="N10152" type="block">1.4.1.2</cms:entry><cms:entry id="N10159" part="chapter1" ref="N10159" type="pagenumber">18</cms:entry><cms:entry id="N1015F" part="chapter1" ref="N1015F" type="block">1.4.1.3</cms:entry><cms:entry id="N10172" part="chapter1" ref="N10172" type="subsection">1.4.2</cms:entry><cms:entry id="N10179" part="chapter1" ref="N10179" type="pagenumber">19</cms:entry><cms:entry id="N1017E" part="chapter1" ref="N1017E" type="block">1.4.2.1</cms:entry><cms:entry id="N1018D" part="chapter1" ref="N1018D" type="block">1.4.2.2</cms:entry><cms:entry id="N10196" part="chapter1" ref="N10196" type="block">1.4.2.3</cms:entry><cms:entry id="N1019A" part="chapter1" ref="N1019A" type="pagenumber">20</cms:entry><cms:entry id="N101A4" part="chapter1" ref="N101A4" type="mm"/><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N101BA" part="chapter2" ref="N101BA" type="pagenumber">21</cms:entry><cms:entry id="N101BF" part="chapter2" ref="N101BF" type="section">2.1</cms:entry><cms:entry id="N101C6" part="chapter2" ref="N101C6" type="table"/><cms:entry id="N102B6" part="chapter2" ref="N102B6" type="section">2.2</cms:entry><cms:entry id="N102BD" part="chapter2" ref="N102BD" type="table"/><cms:entry id="N10528" part="chapter2" ref="N10528" type="pagenumber">22</cms:entry><cms:entry id="N10556" part="chapter2" ref="N10556" type="table"/><cms:entry id="N105F3" part="chapter2" ref="N105F3" type="table"/><cms:entry id="N1063C" part="chapter2" ref="N1063C" type="table"/><cms:entry id="N10729" part="chapter2" ref="N10729" type="section">2.3</cms:entry><cms:entry id="N1072E" part="chapter2" ref="N1072E" type="subsection">2.3.1</cms:entry><cms:entry id="N10738" part="chapter2" ref="N10738" type="pagenumber">23</cms:entry><cms:entry id="N1073E" part="chapter2" ref="N1073E" type="subsection">2.3.2</cms:entry><cms:entry id="N1074A" part="chapter2" ref="N1074A" type="subsection">2.3.3</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N1075C" part="chapter3" ref="N1075C" type="pagenumber">24</cms:entry><cms:entry id="N10761" part="chapter3" ref="N10761" type="section">3.1</cms:entry><cms:entry id="N10766" part="chapter3" ref="N10766" type="subsection">3.1.1</cms:entry><cms:entry id="N1076F" part="chapter3" ref="N1076F" type="subsection">3.1.2</cms:entry><cms:entry id="N10778" part="chapter3" ref="N10778" type="subsection">3.1.3</cms:entry><cms:entry id="N1078A" part="chapter3" ref="N1078A" type="subsection">3.1.4</cms:entry><cms:entry id="N1078E" part="chapter3" ref="N1078E" type="pagenumber">25</cms:entry><cms:entry id="N10797" part="chapter3" ref="N10797" type="subsection">3.1.5</cms:entry><cms:entry id="N107A0" part="chapter3" ref="N107A0" type="subsection">3.1.6</cms:entry><cms:entry id="N107A9" part="chapter3" ref="N107A9" type="subsection">3.1.7</cms:entry><cms:entry id="N107B2" part="chapter3" ref="N107B2" type="subsection">3.1.8</cms:entry><cms:entry id="N107B6" part="chapter3" ref="N107B6" type="pagenumber">26</cms:entry><cms:entry id="N107BE" part="chapter3" ref="N107BE" type="block">3.1.8.1</cms:entry><cms:entry id="N107C7" part="chapter3" ref="N107C7" type="block">3.1.8.2</cms:entry><cms:entry id="N107D1" part="chapter3" ref="N107D1" type="subsection">3.1.9</cms:entry><cms:entry id="N107D8" part="chapter3" ref="N107D8" type="pagenumber">27</cms:entry><cms:entry id="N107E1" part="chapter3" ref="N107E1" type="subsection">3.1.10</cms:entry><cms:entry id="N107ED" part="chapter3" ref="N107ED" type="subsection">3.1.11</cms:entry><cms:entry id="N107F7" part="chapter3" ref="N107F7" type="section">3.2</cms:entry><cms:entry id="N107FB" part="chapter3" ref="N107FB" type="pagenumber">28</cms:entry><cms:entry id="N10800" part="chapter3" ref="N10800" type="subsection">3.2.1</cms:entry><cms:entry id="N10809" part="chapter3" ref="N10809" type="subsection">3.2.2</cms:entry><cms:entry id="N10812" part="chapter3" ref="N10812" type="subsection">3.2.3</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N10821" part="chapter4" ref="N10821" type="pagenumber">29</cms:entry><cms:entry id="N10826" part="chapter4" ref="N10826" type="section">4.1</cms:entry><cms:entry id="N1082B" part="chapter4" ref="N1082B" type="subsection">4.1.1</cms:entry><cms:entry id="N10830" part="chapter4" ref="N10830" type="block">4.1.1.1</cms:entry><cms:entry id="N1083A" part="chapter4" ref="N1083A" type="mm"/><cms:entry id="N1084C" part="chapter4" ref="N1084C" type="mm"/><cms:entry id="N10856" part="chapter4" ref="N10856" type="pagenumber">30</cms:entry><cms:entry id="N1085C" part="chapter4" ref="N1085C" type="block">4.1.1.2</cms:entry><cms:entry id="N10866" part="chapter4" ref="N10866" type="mm"/><cms:entry id="N10872" part="chapter4" ref="N10872" type="block">4.1.1.3</cms:entry><cms:entry id="N10879" part="chapter4" ref="N10879" type="pagenumber">31</cms:entry><cms:entry id="N10883" part="chapter4" ref="N10883" type="mm"/><cms:entry id="N10890" part="chapter4" ref="N10890" type="subsection">4.1.2</cms:entry><cms:entry id="N10897" part="chapter4" ref="N10897" type="pagenumber">32</cms:entry><cms:entry id="N1089F" part="chapter4" ref="N1089F" type="block">4.1.2.1</cms:entry><cms:entry id="N108A9" part="chapter4" ref="N108A9" type="mm"/><cms:entry id="N108B9" part="chapter4" ref="N108B9" type="pagenumber">33</cms:entry><cms:entry id="N108BF" part="chapter4" ref="N108BF" type="block">4.1.2.2</cms:entry><cms:entry id="N108CC" part="chapter4" ref="N108CC" type="mm"/><cms:entry id="N108DC" part="chapter4" ref="N108DC" type="subsection">4.1.3</cms:entry><cms:entry id="N108E0" part="chapter4" ref="N108E0" type="pagenumber">34</cms:entry><cms:entry id="N108EA" part="chapter4" ref="N108EA" type="table"/><cms:entry id="N10986" part="chapter4" ref="N10986" type="table"/><cms:entry id="N109F8" part="chapter4" ref="N109F8" type="block">4.1.3.1</cms:entry><cms:entry id="N109FF" part="chapter4" ref="N109FF" type="mm"/><cms:entry id="N10A0F" part="chapter4" ref="N10A0F" type="pagenumber">35</cms:entry><cms:entry id="N10A15" part="chapter4" ref="N10A15" type="block">4.1.3.2</cms:entry><cms:entry id="N10A1F" part="chapter4" ref="N10A1F" type="mm"/><cms:entry id="N10A2F" part="chapter4" ref="N10A2F" type="pagenumber">36</cms:entry><cms:entry id="N10A33" part="chapter4" ref="N10A33" type="mm"/><cms:entry id="N10A45" part="chapter4" ref="N10A45" type="block">4.1.3.3</cms:entry><cms:entry id="N10A49" part="chapter4" ref="N10A49" type="pagenumber">37</cms:entry><cms:entry id="N10A5F" part="chapter4" ref="N10A5F" type="pagenumber">38</cms:entry><cms:entry id="N10A63" part="chapter4" ref="N10A63" type="mm"/><cms:entry id="N10A71" part="chapter4" ref="N10A71" type="section">4.2</cms:entry><cms:entry id="N10A7B" part="chapter4" ref="N10A7B" type="pagenumber">39</cms:entry><cms:entry id="N10A83" part="chapter4" ref="N10A83" type="subsection">4.2.1</cms:entry><cms:entry id="N10A8B" part="chapter4" ref="N10A8B" type="block">4.2.1.1</cms:entry><cms:entry id="N10A98" part="chapter4" ref="N10A98" type="pagenumber">40</cms:entry><cms:entry id="N10A9C" part="chapter4" ref="N10A9C" type="mm"/><cms:entry id="N10AAE" part="chapter4" ref="N10AAE" type="block">4.2.1.2</cms:entry><cms:entry id="N10AB8" part="chapter4" ref="N10AB8" type="pagenumber">41</cms:entry><cms:entry id="N10ABC" part="chapter4" ref="N10ABC" type="mm"/><cms:entry id="N10ACC" part="chapter4" ref="N10ACC" type="subsection">4.2.2</cms:entry><cms:entry id="N10AD4" part="chapter4" ref="N10AD4" type="block">4.2.2.1</cms:entry><cms:entry id="N10ADB" part="chapter4" ref="N10ADB" type="pagenumber">42</cms:entry><cms:entry id="N10AE2" part="chapter4" ref="N10AE2" type="mm"/><cms:entry id="N10AEE" part="chapter4" ref="N10AEE" type="block">4.2.2.2</cms:entry><cms:entry id="N10AF8" part="chapter4" ref="N10AF8" type="pagenumber">43</cms:entry><cms:entry id="N10B02" part="chapter4" ref="N10B02" type="mm"/><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N10B18" part="chapter5" ref="N10B18" type="pagenumber">44</cms:entry><cms:entry id="N10B1D" part="chapter5" ref="N10B1D" type="section">5.1</cms:entry><cms:entry id="N10B22" part="chapter5" ref="N10B22" type="subsection">5.1.1</cms:entry><cms:entry id="N10B2C" part="chapter5" ref="N10B2C" type="mm"/><cms:entry id="N10B35" part="chapter5" ref="N10B35" type="subsection">5.1.2</cms:entry><cms:entry id="N10B3F" part="chapter5" ref="N10B3F" type="pagenumber">45</cms:entry><cms:entry id="N10B43" part="chapter5" ref="N10B43" type="mm"/><cms:entry id="N10B4F" part="chapter5" ref="N10B4F" type="subsection">5.1.3</cms:entry><cms:entry id="N10B59" part="chapter5" ref="N10B59" type="pagenumber">46</cms:entry><cms:entry id="N10B5D" part="chapter5" ref="N10B5D" type="mm"/><cms:entry id="N10B6C" part="chapter5" ref="N10B6C" type="subsection">5.1.4</cms:entry><cms:entry id="N10B76" part="chapter5" ref="N10B76" type="pagenumber">47</cms:entry><cms:entry id="N10B7A" part="chapter5" ref="N10B7A" type="mm"/><cms:entry id="N10B87" part="chapter5" ref="N10B87" type="section">5.2</cms:entry><cms:entry id="N10B95" part="chapter5" ref="N10B95" type="subsection">5.2.1</cms:entry><cms:entry id="N10B9C" part="chapter5" ref="N10B9C" type="pagenumber">48</cms:entry><cms:entry id="N10BA6" part="chapter5" ref="N10BA6" type="mm"/><cms:entry id="N10BB8" part="chapter5" ref="N10BB8" type="subsection">5.2.2</cms:entry><cms:entry id="N10BBF" part="chapter5" ref="N10BBF" type="pagenumber">49</cms:entry><cms:entry id="N10BD2" part="chapter5" ref="N10BD2" type="pagenumber">50</cms:entry><cms:entry id="N10BD6" part="chapter5" ref="N10BD6" type="mm"/><cms:entry id="chapter6" part="chapter6" ref="chapter6" type="chapter">6</cms:entry><cms:entry id="N10BE8" part="chapter6" ref="N10BE8" type="pagenumber">51</cms:entry><cms:entry id="N10BF3" part="chapter6" ref="N10BF3" type="section">6.1</cms:entry><cms:entry id="N10C00" part="chapter6" ref="N10C00" type="pagenumber">52</cms:entry><cms:entry id="N10C0D" part="chapter6" ref="N10C0D" type="pagenumber">53</cms:entry><cms:entry id="N10C23" part="chapter6" ref="N10C23" type="pagenumber">54</cms:entry><cms:entry id="N10C30" part="chapter6" ref="N10C30" type="pagenumber">55</cms:entry><cms:entry id="N10C39" part="chapter6" ref="N10C39" type="section">6.2</cms:entry><cms:entry id="N10C4F" part="chapter6" ref="N10C4F" type="pagenumber">56</cms:entry><cms:entry id="N10C5F" part="chapter6" ref="N10C5F" type="pagenumber">57</cms:entry><cms:entry id="N10C6C" part="N10C6C" ref="N10C6C" type="abbreviation">
				
Abkürzungen:</cms:entry><cms:entry id="N10C70" part="N10C6C" ref="N10C70" type="pagenumber">7</cms:entry><cms:entry id="N10C77" part="N10C6C" ref="N10C77" type="table"/><cms:entry id="N11057" part="N11057" ref="N11057" type="bibliography">
				
Referenzen</cms:entry><cms:entry id="N1105B" part="N11057" ref="N1105B" type="pagenumber">58</cms:entry><cms:entry id="N111E7" part="N11057" ref="N111E7" type="pagenumber">59</cms:entry><cms:entry id="N113D3" part="N11057" ref="N113D3" type="pagenumber">60</cms:entry><cms:entry id="N115D6" part="N11057" ref="N115D6" type="pagenumber">61</cms:entry><cms:entry id="N1175D" part="N11057" ref="N1175D" type="pagenumber">62</cms:entry><cms:entry id="N11895" part="N11895" ref="N11895" type="acknowledgement">
				Danksagung</cms:entry><cms:entry id="N11899" part="N11895" ref="N11899" type="pagenumber">63</cms:entry><cms:entry id="N118C6" part="N118C6" ref="N118C6" type="vita">
				
Lebenslauf von Maximilian Posch</cms:entry><cms:entry id="N118CA" part="N118C6" ref="N118CA" type="pagenumber">64</cms:entry><cms:entry ref="N11915" type="appendix">
				
Veröffentlichungen:</cms:entry><cms:entry ref="N11919" type="pagenumber">65</cms:entry><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><appendix id="N11915">
			<head>
				<pagenumber id="N11919" label="65" numbering="arabic" start="65"/>
Veröffentlichungen:</head>
			<p>
				<strong>Oral Presentation:</strong>
			</p>
			<p>
				<em>
					<strong>A novel bcl-2/bcl-xL bispecific Antisense oligonucleotide that induces tumor cell Apoptosis</strong>
				</em>
			</p>
			<p>
				<em>
					<strong>and synergistically interacts with chemotherapy</strong>
				</em>
			</p>
			<p>
				<em>Posch M, Gautschi O, Olie RA, Simoês-Wüst AP, Baumann B, Elstner E, Stahel RA and Zangemeister-Wittke</em>
			</p>
			<p>VORGETRAGEN IM NOVEMBER 2000 AUF DER 11TH EUROPEAN STUDENT CONFERENCE IN DER CHARITÉ, BERLIN</p>
			<p>
				<strong>Poster:</strong>
			</p>
			<p>
				<em>
					<strong>Targeted therapy of solid tumors with anovel Ep-cam specific immunotoxin obtained by</strong>
				</em>
			</p>
			<p>
				<em>
					<strong>fusion of pseudomonas exotoxin A to the high affinity scFv 4D5MOC-B</strong>
				</em>
			</p>
			<p>
				<em>Posch M, Olie RA, Müller M, Willuda J, Kubetzko S, Plückthun A, Stahel RA, Zangemeister-Wittke U</em>
			</p>
			<p>PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 42, 4151 MARCH 24-28 2001 NEW</p>
			<p>ORLEANs, LA, USA</p>
			<p>
				<strong>Poster:</strong>
			</p>
			<p>
				<em>
					<strong>Effects of PPAR-gamma- and RAR-Ligands on glioblastoma cells</strong>
				</em>
			</p>
			<p>
				<em>E.Elstner, M wächter, C. Zang, M.G. Posch, J. Reichardt, J. Fritz, A. Klügel, H. Liu, A. von Deimling, K.</em>
			</p>
			<p>
				<em>Possinger and H.P. Koeffler</em>
			</p>
			<p>
				<em>
					<strong>Activity of the Bcl-2/Bcl-xL bispecific antisense oligonucleotide 4625 on tumor growth in</strong>
				</em>
			</p>
			<p>
				<em>
					<strong>combination with chemotherapy</strong>
				</em>
			</p>
			<p>Posch M.G., Elstner E., Zangemeister-Wittke U.</p>
			<p>
				<em>BEIDE POSTER PRÄSENTIERT AUF DER GEM JAHRESTAGUNG DER DEUTSCHEN GESELLSCHAFT FÜR HÄMATOLOGIE</em>
			</p>
			<p>
				<em>UND ONKOLOGIE IM SEPTEMBER </em>
				<em>2001 </em>
				<em>IN MANNHEIM</em>
			</p>
			<p>
				<strong>Oral Presentation:</strong>
			</p>
			<p>
				<em>
					<strong>Anti-tumor activity of the BCL-2/BCL-XL bispecific antisense oligonucleotide 4625 on</strong>
				</em>
			</p>
			<p>
				<em>
					<strong>tumor growth in vitro and on nude mice xenografts in combination with chemotherapy</strong>
				</em>
			</p>
			<p>
				<em>Posch M.G., Zangemeister Wittke U., Elstner E.</em>
			</p>
			<p>
				<em>INTERNATIONAL SOCIETY FOR CANCER GENE THERAP</em>
				<em>Y. </em>
				<em>TENTH INTERNATIONAL CONFERENCE ON GENE THERAPY</em>
			</p>
			<p>
				<em>OF CANCE</em>
				<em>R, </em>
				<em>DECEMBER </em>
				<em>13-15 2001, </em>
				<em>SAN DIEG</em>
				<em>o, CA, USA</em>
			</p>
			<p>
				<strong>Poster:</strong>
			</p>
			<p>
				<em>
					<strong>Peroxisome Proliferator-Activated Receptor gamma ligands induce growth inhibition and</strong>
				</em>
			</p>
			<p>
				<em>
					<strong>apoptosis of human lymphocytic leukemia in vitro</strong>
				</em>
			</p>
			<p>Zang C., Kluegel A., Posch M., Waechter M., liu H., Doudina O., Becker M., Ruthardt M., Possinger K., Elstner E.</p>
			<p>
				<em>AMERICAN SOCIETY OF HEMATOLOGY</em>
				<em>. 3</em>
				<em>4RD ANNUAL MEETING AND EXPOSITION</em>
				<em>, </em>
				<em>DECEMBER </em>
				<em>7-11 2001, </em>
				<em>ORLAND</em>
				<em>o, FL, USA</em>
			</p>
			<p>Ich erkläre hiermit an eides statt, daß ich die vorliegende Dissertationsschrift ohne unzulässige Hilfe Dritter und nur unter der Verwendung der angegeben Hilfsmittel angefertigt habe. Die Arbeit besteht auch in Teilen nicht aus Kopien anderer Arbeiten.</p>
			<p>Maximilian Posch











</p>
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