Die neurotoxische Wirkung der Zytostatika Cyclophosphamid und Thiotepa im infantilen Gehirn der RatteSusanne PruskilWidmungAbkürzungsverzeichnis1.11.12341.2561.371.4891.5101.5.1111.5.212131.61.6.1141.6.2151.7162.162.12.217182.31920212.42223242.52.6252.72.8263.263.127283.229303.331323.4333.5343.6354.354.14.2364.2.14.2.237384.3394.4404.5414.6424.743444.85.45466. LiteraturverzeichnisPublikationenEidesstattliche ErklärungDanksagungdeInhaltsverzeichnisHilfe 6. Literaturverzeichnis Aktories, K.; Förstermann, U.; Hofmann, F. und Starke, K. (2005): Allgemeine und spezielle Pharmakologie und Toxikologie, Urban und Fischer Verlag, (Band 9. Auflage). Asato, R.; Akiyama, Y.; Ito, M.; Kubota, M.; Okumura, R.; Miki, Y.; Konishi, J. und Mikawa, H. (1992): Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate, Cancer, (Band 70), Nr. 7, Seite 1997-2004. Barinaga, M. (1996): Forging a path to cell death, Science, (Band 273), Nr. 5276, Seite 735-7. Benveniste, H.; Drejer, J.; Schousboe, A. und Diemer, N. H. (1984): Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J Neurochem, (Band 43), Nr. 5, Seite 1369-74. Boaziz, C.; Breau, J. L.; Morere, J. F. und Israel, L. (1991): [The blood-brain barrier: implications for chemotherapy in brain tumors], Pathol Biol (Paris), (Band 39), Nr. 8, Seite 789-95. Borovitskaya, A. E.; Evtushenko, V. I. und Sabol, S. L. (1996): Gamma-radiation-induced cell death in the fetal rat brain possesses molecular characteristics of apoptosis and is associated with specific messenger RNA elevations, Brain Res Mol Brain Res, (Band 35), Nr. 1-2, Seite 19-30. Bossy-Wetzel, E.; Bakiri, L. und Yaniv, M. (1997): Induction of apoptosis by the transcription factor c-Jun, Embo J, (Band 16), Nr. 7, Seite 1695-709. Bossy-Wetzel, E.; Barsoum, M. J.; Godzik, A.; Schwarzenbacher, R. und Lipton, S. A. (2003): Mitochondrial fission in apoptosis, neurodegeneration and aging, Curr Opin Cell Biol, (Band 15), Nr. 6, Seite 706-16. Bregman, C. L.; Buroker, R. A.; Hirth, R. S.; Crosswell, A. R. und Durham, S. K. (1994): Etoposide- and BMY-40481-induced sensory neuropathy in mice, Toxicol Pathol, (Band 22), Nr. 5, Seite 528-35. Brown, R. T.; Sawyer, M. G.; Antoniou, G.; Toogood, I. und Rice, M. (1999): Longitudinal follow-up of the intellectual and academic functioning of children receiving central nervous system-prophylactic chemotherapy for leukemia: a four-year final report, J Dev Behav Pediatr, (Band 20), Nr. 5, Seite 373-7. Charriaut_Marlangue, C. und Ben_Ari, Y. (1995): A cautionary note on the use of the TUNEL stain to determine apoptosis., Neuroreport, (Band 7), Nr. 1, Seite 61-4. Choi, D. W. (1996): Ischemia-induced neuronal apoptosis, Curr Opin Neurobiol, (Band 6), Nr. 5, Seite 667-72. Colicos, M. A. und Dash, P. K. (1996): Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits, Brain Res, (Band 739), Nr. 1-2, Seite 120-31. Colvin, O. M. (1999): An overview of cyclophosphamide development and clinical applications, Curr Pharm Des, (Band 5), Nr. 8, Seite 555-60. Creutzig, U (2005): Therapieerfolge, Crowe, M. J.; Bresnahan, J. C.; Shuman, S. L.; Masters, J. N. und Beattie, M. S. (1997): Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys, Nat Med, (Band 3), Nr. 1, Seite 73-6. Cruz_Orive, L.M. und Weibel, E.R. (1990): Recent stereological methods for cell biology: a brief survey., American Journal of Physiology, (Band 258), Nr. 4 Pt 1, Seite L148-56. DeOlmos, J.S. und Ingram, W.R. (1971): An improved cupric-silver method for impregnation of axonal and terminal degeneration., Brain Research, (Band 33), Nr. 2, Seite 523-9. Dikranian, K.; Ishimaru, M. J.; Tenkova, T.; Labruyere, J.; Qin, Y. Q.; Ikonomidou, C. und Olney, J. W. (2001): Apoptosis in the in vivo mammalian forebrain, Neurobiol Dis, (Band 8), Nr. 3, Seite 359-79. Dobbing, J. (1974): The later growth of the brain and its vulnerability, Pediatrics, (Band 53), Nr. 1, Seite 2-6. Dobbing, J. (1974): The later growth of the brain and its vulnerability., Pediatrics, (Band 53), Nr. 1, Seite 2-6. el-Badawi, M. G.; Fatani, J. A.; Bahakim, H. und Abdalla, M. A. (1990): Light and electron microscopic observations on the cerebellum of guinea pigs following low-dose methotrexate, Exp Mol Pathol, (Band 53), Nr. 3, Seite 211-22. Forman, A. (1990): Recent studies on neurotoxicity and on the epidemiology of brain and nervous system tumors, Curr Opin Oncol, (Band 2), Nr. 4, Seite 691-8. Friesen, C.; Herr, I.; Krammer, P. H. und Debatin, K. M. (1996): Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells, Nat Med, (Band 2), Nr. 5, Seite 574-7. Fuchs, H. E.; Archer, G. E.; Colvin, O. M.; Bigner, S. H.; Schuster, J. M.; Fuller, G. N.; Muhlbaier, L. H.; Schold, S. C., Jr.; Friedman, H. S. und Bigner, D. D. (1990): Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis, Cancer Res, (Band 50), Nr. 6, Seite 1954-9. Fulda, S.; Strauss, G.; Meyer, E. und Debatin, K. M. (2000): Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells, Blood, (Band 95), Nr. 1, Seite 301-8. Garcia-Tena, J.; Lopez-Andreu, J. A.; Ferris, J.; Menor, F.; Mulas, F.; Millet, E. und Verdeguer, A. (1995): Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukemia, Pediatr Hematol Oncol, (Band 12), Nr. 4, Seite 377-85. Gavrieli, Y.; Sherman, Y. und Ben_Sasson, S.A. (1992): Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation., Journal of Cell Biology, (Band 119), Nr. 3, Seite 493-501. Globus, M. Y.; Busto, R.; Dietrich, W. D.; Martinez, E.; Valdes, I. und Ginsberg, M. D. (1988): Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis, J Neurochem, (Band 51), Nr. 5, Seite 1455-64. Golstein, P. (1997): Controlling cell death, Science, (Band 275), Nr. 5303, Seite 1081-2. Gozdz, A.; Habas, A.; Jaworski, J.; Zielinska, M.; Albrecht, J.; Chlystun, M.; Jalili, A. und Hetman, M. (2003): Role of N-methyl-D-aspartate receptors in the neuroprotective activation of extracellular signal-regulated kinase 1/2 by cisplatin, J Biol Chem, (Band 278), Nr. 44, Seite 43663-71. Graham, M. L.; Herndon, J. E., 2nd; Casey, J. R.; Chaffee, S.; Ciocci, G. H.; Krischer, J. P.; Kurtzberg, J.; Laughlin, M. J.; Longee, D. C.; Olson, J. F.; Paleologus, N.; Pennington, C. N. und Friedman, H. S. (1997): High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors, J Clin Oncol, (Band 15), Nr. 5, Seite 1814-23. Grasl_Kraupp, B.; Ruttkay_Nedecky, B.; Koudelka, H.; Bukowska, K.; Bursch, W. und Schulte_Hermann, R. (1995): In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note., Hepatology, (Band 21), Nr. 5, Seite 1465-8. Gurney, J. G.; Severson, R. K.; Davis, S. und Robison, L. L. (1995): Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type, Cancer, (Band 75), Nr. 8, Seite 2186-95. Ha, H. C. und Snyder, S. H. (2000): Poly(ADP-ribose) polymerase-1 in the nervous system, Neurobiol Dis, (Band 7), Nr. 4, Seite 225-39. Hengartner, M. O. (2000): The biochemistry of apoptosis, Nature, (Band 407), Nr. 6805, Seite 770-6. Henze, G. (1997): Childhood acute lymphoblastic leukaemia, Eur J Cancer, (Band 33), Nr. 1, Seite 8-9. Henze, G.; Langermann, H. J.; Ritter, J.; Schellong, G. und Riehm, H. (1981): Treatment strategy for different risk groups in childhood acute lymphoblastic leukemia: A Report From the BFM Study Group, Haematol Blood Transfus, (Band 26), Seite 87-93. Highley, M.; Meller, S. T. und Pinkerton, C. R. (1992): Seizures and cortical dysfunction following high-dose cisplatin administration in children, Med Pediatr Oncol, (Band 20), Nr. 2, Seite 143-8. Hook, C. C.; Kimmel, D. W.; Kvols, L. K.; Scheithauer, B. W.; Forsyth, P. A.; Rubin, J.; Moertel, C. G. und Rodriguez, M. (1992): Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole, Ann Neurol, (Band 31), Nr. 3, Seite 262-7. Hu, Y.; Benedict, M. A.; Ding, L. und Nunez, G. (1999): Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis, Embo J, (Band 18), Nr. 13, Seite 3586-95. Hussain, M.; Wozniak, A. J. und Edelstein, M. B. (1993): Neurotoxicity of antineoplastic agents, Crit Rev Oncol Hematol, (Band 14), Nr. 1, Seite 61-75. Ikonomidou, C.; Bosch, F.; Miksa, M.; Bittigau, P.; Vockler, J.; Dikranian, K.; Tenkova, T. I.; Stefovska, V.; Turski, L. und Olney, J. W. (1999): Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain, Science, (Band 283), Nr. 5398, Seite 70-4. Ikonomidou, C.; Mosinger, J. L.; Salles, K. S.; Labruyere, J. und Olney, J. W. (1989): Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity, J Neurosci, (Band 9), Nr. 8, Seite 2809-18. Ikonomidou, C.; Price, M. T.; Mosinger, J. L.; Frierdich, G.; Labruyere, J.; Salles, K. S. und Olney, J. W. (1989): Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain, J Neurosci, (Band 9), Nr. 5, Seite 1693-700. Ikonomidou, C.; Qin, Y.; Labruyere, J.; Kirby, C. und Olney, J. W. (1996): Prevention of trauma-induced neurodegeneration in infant rat brain, Pediatr Res, (Band 39), Nr. 6, Seite 1020-7. Ikonomidou, C.; Stefovska, V. und Turski, L. (2000): Neuronal death enhanced by N-methyl-D-aspartate antagonists, Proc Natl Acad Sci U S A, (Band 97), Nr. 23, Seite 12885-90. Inamura, T.; Nomura, T.; Bartus, R. T. und Black, K. L. (1994): Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors, J Neurosurg, (Band 81), Nr. 5, Seite 752-8. Ishimaru, M. J.; Ikonomidou, C.; Tenkova, T. I.; Der, T. C.; Dikranian, K.; Sesma, M. A. und Olney, J. W. (1999): Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain, J Comp Neurol, (Band 408), Nr. 4, Seite 461-76. Jain, R. K. (1989): Delivery of novel therapeutic agents in tumors: physiological barriers and strategies, J Natl Cancer Inst, (Band 81), Nr. 8, Seite 570-6. Kaatsch P, Spix C, Michaelis J (2002): German childhood cancer registry-annual report 2000 (Jahresbericht 2000 des Deutschen Kinderkrebsregisters), Deutsches Kinderkrebsregister, ed 2002. Kaplan, R. S. und Wiernik, P. H. (1982): Neurotoxicity of antineoplastic drugs, Semin Oncol, (Band 9), Nr. 1, Seite 103-30. Keime-Guibert, F.; Napolitano, M. und Delattre, J. Y. (1998): Neurological complications of radiotherapy and chemotherapy, J Neurol, (Band 245), Nr. 11, Seite 695-708. Kerr, J. F.; Wyllie, A. H. und Currie, A. R. (1972): Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, (Band 26), Nr. 4, Seite 239-57. Kim, R.; Tanabe, K.; Uchida, Y.; Emi, M.; Inoue, H. und Toge, T. (2002): Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy, Cancer Chemother Pharmacol, (Band 50), Nr. 5, Seite 343-52. Kramer, J. H.; Crittenden, M. R.; DeSantes, K. und Cowan, M. J. (1997): Cognitive and adaptive behavior 1 and 3 years following bone marrow transplantation, Bone Marrow Transplant, (Band 19), Nr. 6, Seite 607-13. Kroemer, G. (1997): The proto-oncogene Bcl-2 and its role in regulating apoptosis, Nat Med, (Band 3), Nr. 6, Seite 614-20. Lawen, A. (2003): Apoptosis-an introduction, Bioessays, (Band 25), Nr. 9, Seite 888-96. Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S. M.; Ahmad, M.; Alnemri, E. S. und Wang, X. (1997): Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, (Band 91), Nr. 4, Seite 479-89. Lipton, S. A. und Rosenberg, P. A. (1994): Excitatory amino acids as a final common pathway for neurologic disorders, N Engl J Med, (Band 330), Nr. 9, Seite 613-22. Liu, X. Z.; Xu, X. M.; Hu, R.; Du, C.; Zhang, S. X.; McDonald, J. W.; Dong, H. X.; Wu, Y. J.; Fan, G. S.; Jacquin, M. F.; Hsu, C. Y. und Choi, D. W. (1997): Neuronal and glial apoptosis after traumatic spinal cord injury, J Neurosci, (Band 17), Nr. 14, Seite 5395-406. Macdonald, D. R. (1991): Neurologic complications of chemotherapy, Neurol Clin, (Band 9), Nr. 4, Seite 955-67. MacDonald, T. J.; Rood, B. R.; Santi, M. R.; Vezina, G.; Bingaman, K.; Cogen, P. H. und Packer, R. J. (2003): Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors, Oncologist, (Band 8), Nr. 2, Seite 174-86. Miyashita, K.; Abe, H.; Nakajima, T.; Ishikawa, A.; Nishiura-Suzuki, M.; Naritomi, H.; Tanaka, R. und Sawada, T. (1994): Glutamate release in the gerbil hippocampus after middle cerebral artery occlusion, Neuroreport, (Band 5), Nr. 8, Seite 945-8. Mizutani, T (1995): Neurologic complications of cancer. Their pathogenesis and management., Biotherapy, (Band 9), Seite 1472-1479. Muller, M.; Wilder, S.; Bannasch, D.; Israeli, D.; Lehlbach, K.; Li-Weber, M.; Friedman, S. L.; Galle, P. R.; Stremmel, W.; Oren, M. und Krammer, P. H. (1998): p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs, J Exp Med, (Band 188), Nr. 11, Seite 2033-45. Murphy, A. N.; Fiskum, G. und Beal, M. F. (1999): Mitochondria in neurodegeneration: bioenergetic function in cell life and death, J Cereb Blood Flow Metab, (Band 19), Nr. 3, Seite 231-45. Olney, J. W. (1971): Glutamate-induced neuronal necrosis in the infant mouse hypothalamus. An electron microscopic study, J Neuropathol Exp Neurol, (Band 30), Nr. 1, Seite 75-90. Olney, J. W. (2003): Excitotoxicity, apoptosis and neuropsychiatric disorders, Curr Opin Pharmacol, (Band 3), Nr. 1, Seite 101-9. Olney, J. W.; Adamo, N. J. und Ratner, A. (1971): Monosodium glutamate effects, Science, (Band 172), Nr. 980, Seite 294. Packer, R. J. (1995): Brain tumors in children, Curr Opin Pediatr, (Band 7), Nr. 1, Seite 64-72. Palmer, S. L.; Goloubeva, O.; Reddick, W. E.; Glass, J. O.; Gajjar, A.; Kun, L.; Merchant, T. E. und Mulhern, R. K. (2001): Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis, J Clin Oncol, (Band 19), Nr. 8, Seite 2302-8. Park, D. S.; Morris, E. J.; Padmanabhan, J.; Shelanski, M. L.; Geller, H. M. und Greene, L. A. (1998): Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents, J Cell Biol, (Band 143), Nr. 2, Seite 457-67. Park, D. S.; Morris, E. J.; Stefanis, L.; Troy, C. M.; Shelanski, M. L.; Geller, H. M. und Greene, L. A. (1998): Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress, J Neurosci, (Band 18), Nr. 3, Seite 830-40. Perry, M. C. (2001): The Chemotherapy Source Book, Lippincott Williams and Wilkins, (Band Third Edition). Persson, L. und Hillered, L. (1992): Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis, J Neurosurg, (Band 76), Nr. 1, Seite 72-80. Phipps, S.; Dunavant, M.; Srivastava, D. K.; Bowman, L. und Mulhern, R. K. (2000): Cognitive and academic functioning in survivors of pediatric bone marrow transplantation, J Clin Oncol, (Band 18), Nr. 5, Seite 1004-11. Ravindranath, Y. (2003): Recent advances in pediatric acute lymphoblastic and myeloid leukemia, Curr Opin Oncol, (Band 15), Nr. 1, Seite 23-35. Reddy, A. T. und Witek, K. (2003): Neurologic complications of chemotherapy for children with cancer, Curr Neurol Neurosci Rep, (Band 3), Nr. 2, Seite 137-42. Robison, L. L. und Bhatia, S. (2003): Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence, Br J Haematol, (Band 122), Nr. 3, Seite 345-59. Rothman, S. (1984): Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, J Neurosci, (Band 4), Nr. 7, Seite 1884-91. Rothman, S. M. und Olney, J. W. (1995): Excitotoxicity and the NMDA receptor--still lethal after eight years, Trends Neurosci, (Band 18), Nr. 2, Seite 57-8. Rubnitz, J. E. und Pui, C. H. (2003): Recent advances in the treatment and understanding of childhood acute lymphoblastic leukaemia, Cancer Treat Rev, (Band 29), Nr. 1, Seite 31-44. Rutkowski, S. (2003): HIT 2000, Rzeski, W.; Jansma, C.; Reiher, AK.; Bosch, F.; Bittigau, P.; Vöckler, J. und Ikonomidou, C. (1998): Excitotoxicity and apoptosis mediate neuronal toxicity of cytostatic agents, Society for Neuroscience 27th Annual Meeting, Los Angeles, CA. Rzeski, W.; Pruskil, S.; Macke, A.; Felderhoff-Mueser, U.; Reiher, A. K.; Hoerster, F.; Jansma, C.; Jarosz, B.; Stefovska, V.; Bittigau, P. und Ikonomidou, C. (2004): Anticancer agents are potent neurotoxins in vitro and in vivo, Ann Neurol, (Band 56), Nr. 3, Seite 351-60. Shapiro, W. R.; Green, S. B.; Burger, P. C.; Selker, R. G.; VanGilder, J. C.; Robertson, J. T.; Mealey, J., Jr.; Ransohff, J. und Mahaley, M. S., Jr. (1992): A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma, J Neurosurg, (Band 76), Nr. 5, Seite 772-81. Silverstein, F. S.; Buchanan, K. und Johnston, M. V. (1986): Perinatal hypoxia-ischemia disrupts striatal high-affinity [3H]glutamate uptake into synaptosomes, J Neurochem, (Band 47), Nr. 5, Seite 1614-9. Simms, S.; Kazak, A. E.; Golomb, V.; Goldwein, J. und Bunin, N. (2002): Cognitive, behavioral, and social outcome in survivors of childhood stem cell transplantation, J Pediatr Hematol Oncol, (Band 24), Nr. 2, Seite 115-9. Solary, E.; Droin, N.; Bettaieb, A.; Corcos, L.; Dimanche-Boitrel, M. T. und Garrido, C. (2000): Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies, Leukemia, (Band 14), Nr. 10, Seite 1833-49. Souid, A. K.; Tacka, K. A.; Galvan, K. A. und Penefsky, H. S. (2003): Immediate effects of anticancer drugs on mitochondrial oxygen consumption, Biochem Pharmacol, (Band 66), Nr. 6, Seite 977-87. Steinberg, S.; Hartmann, R.; Wisniewski, S.; Berger, K.; Beck, J. D. und Henze, G. (1998): [Late sequelae of CNS recurrence of acute lymphoblastic leukemia in childhood], Klin Padiatr, (Band 210), Nr. 4, Seite 200-6. Steller, H. (1995): Mechanisms and genes of cellular suicide, Science, (Band 267), Nr. 5203, Seite 1445-9. Tallen, Gesche (2003): Bösartige Erkrankungen bei Kindern und Jugendlichen, Tallen, Gesche (2003): Therapieerfolge. Tecoma, E. S.; Monyer, H.; Goldberg, M. P. und Choi, D. W. (1989): Traumatic neuronal injury in vitro is attenuated by NMDA antagonists, Neuron, (Band 2), Nr. 6, Seite 1541-5. Thompson, C. B. (1995): Apoptosis in the pathogenesis and treatment of disease, Science, (Band 267), Nr. 5203, Seite 1456-62. Uchiyama-Tsuyuki, Y.; Araki, H.; Yae, T. und Otomo, S. (1994): Changes in the extracellular concentrations of amino acids in the rat striatum during transient focal cerebral ischemia, J Neurochem, (Band 62), Nr. 3, Seite 1074-8. Vaux, D. L. und Korsmeyer, S. J. (1999): Cell death in development, Cell, (Band 96), Nr. 2, Seite 245-54. Verstappen, C. C.; Heimans, J. J.; Hoekman, K. und Postma, T. J. (2003): Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management, Drugs, (Band 63), Nr. 15, Seite 1549-63. Wallace, T. L. und Johnson, E. M., Jr. (1989): Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis, J Neurosci, (Band 9), Nr. 1, Seite 115-24. Wallach, D. (1997): Apoptosis. Placing death under control, Nature, (Band 388), Nr. 6638, Seite 123, 125-6. Whitehead, V. M.; Vuchich, M. J.; Lauer, S. J.; Mahoney, D.; Carroll, A. J.; Shuster, J. J.; Esseltine, D. W.; Payment, C.; Look, A. T.; Akabutu, J. und et al. (1992): Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study, Blood, (Band 80), Nr. 5, Seite 1316-23. Williams, G. T. und Smith, C. A. (1993): Molecular regulation of apoptosis: genetic controls on cell death, Cell, (Band 74), Nr. 5, Seite 777-9. Yim, Y. S.; Mahoney, D. H., Jr. und Oshman, D. G. (1991): Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia, Cancer, (Band 67), Nr. 8, Seite 2058-61. Zhou, B. B. und Elledge, S. J. (2000): The DNA damage response: putting checkpoints in perspective, Nature, (Band 408), Nr. 6811, Seite 433-9.