<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Experimentelle Melanin-induzierte Uveitis Modulation der Leukozyten-Endothelzell-Interaktion durch Makrophagendepletion  - Intravitalmikroskopische Analysen -</cms:entry><cms:entry type="author">Joachim  Puchta
         </cms:entry><cms:entry id="N10033" part="front" ref="N10033" type="pagenumber">2</cms:entry><cms:entry id="N1005C" part="front" ref="N1005C" type="pagenumber">3</cms:entry><cms:entry id="N10060" part="front" ref="N10060" type="dedication"/><cms:entry id="N1006B" part="N1006B" ref="N1006B" type="preface">Fragestellung</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="N1007F" part="chapter1" ref="N1007F" type="pagenumber">8</cms:entry><cms:entry id="N10083" part="chapter1" ref="N10083" type="section">1.1</cms:entry><cms:entry id="N1009E" part="chapter1" ref="N1009E" type="section">1.2</cms:entry><cms:entry id="N100B0" part="chapter1" ref="N100B0" type="pagenumber">9</cms:entry><cms:entry id="N100B4" part="chapter1" ref="N100B4" type="section">1.3</cms:entry><cms:entry id="N100BD" part="chapter1" ref="N100BD" type="subsection">1.3.1</cms:entry><cms:entry id="N100C6" part="chapter1" ref="N100C6" type="pagenumber">10</cms:entry><cms:entry id="N100D0" part="chapter1" ref="N100D0" type="section">1.4</cms:entry><cms:entry id="N100EE" part="chapter1" ref="N100EE" type="section">1.5</cms:entry><cms:entry id="N100F1" part="chapter1" ref="N100F1" type="pagenumber">11</cms:entry><cms:entry id="N1010D" part="chapter1" ref="N1010D" type="section">1.6</cms:entry><cms:entry id="N10110" part="chapter1" ref="N10110" type="pagenumber">12</cms:entry><cms:entry id="N10135" part="chapter1" ref="N10135" type="pagenumber">13</cms:entry><cms:entry id="N1013C" part="chapter1" ref="N1013C" type="mm">538#744</cms:entry><cms:entry id="N1016B" part="chapter1" ref="N1016B" type="section">1.7</cms:entry><cms:entry id="N1016E" part="chapter1" ref="N1016E" type="pagenumber">14</cms:entry><cms:entry id="N10175" part="chapter1" ref="N10175" type="section">1.8</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10181" part="chapter2" ref="N10181" type="pagenumber">15</cms:entry><cms:entry id="N10185" part="chapter2" ref="N10185" type="section">2.1</cms:entry><cms:entry id="N1018E" part="chapter2" ref="N1018E" type="section">2.2</cms:entry><cms:entry id="N10197" part="chapter2" ref="N10197" type="section">2.3</cms:entry><cms:entry id="N1019A" part="chapter2" ref="N1019A" type="subsection">2.3.1</cms:entry><cms:entry id="N101A3" part="chapter2" ref="N101A3" type="subsection">2.3.2</cms:entry><cms:entry id="N101AF" part="chapter2" ref="N101AF" type="section">2.4</cms:entry><cms:entry id="N101BB" part="chapter2" ref="N101BB" type="pagenumber">16</cms:entry><cms:entry id="N101BF" part="chapter2" ref="N101BF" type="section">2.5</cms:entry><cms:entry id="N101CE" part="chapter2" ref="N101CE" type="subsection">2.5.1</cms:entry><cms:entry id="N101E3" part="chapter2" ref="N101E3" type="mm">485#365</cms:entry><cms:entry id="N101F4" part="chapter2" ref="N101F4" type="section">2.6</cms:entry><cms:entry id="N101F7" part="chapter2" ref="N101F7" type="pagenumber">17</cms:entry><cms:entry id="N10210" part="chapter2" ref="N10210" type="mm">585#389</cms:entry><cms:entry id="N10221" part="chapter2" ref="N10221" type="section">2.7</cms:entry><cms:entry id="N1022D" part="chapter2" ref="N1022D" type="pagenumber">18</cms:entry><cms:entry id="N10237" part="chapter2" ref="N10237" type="mm">585#471</cms:entry><cms:entry id="N1024B" part="chapter2" ref="N1024B" type="section">2.8</cms:entry><cms:entry id="N1024E" part="chapter2" ref="N1024E" type="pagenumber">19</cms:entry><cms:entry id="N1025E" part="chapter2" ref="N1025E" type="mm">333#45</cms:entry><cms:entry id="N10265" part="chapter2" ref="N10265" type="section">2.9</cms:entry><cms:entry id="N1026B" part="chapter2" ref="N1026B" type="section">2.10</cms:entry><cms:entry id="N10277" part="chapter2" ref="N10277" type="section">2.11</cms:entry><cms:entry id="N10288" part="chapter2" ref="N10288" type="pagenumber">20</cms:entry><cms:entry id="N1028F" part="chapter2" ref="N1028F" type="section">2.12</cms:entry><cms:entry id="N1029E" part="chapter2" ref="N1029E" type="section">2.13</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N102A7" part="chapter3" ref="N102A7" type="pagenumber">21</cms:entry><cms:entry id="N102AB" part="chapter3" ref="N102AB" type="section">3.1</cms:entry><cms:entry id="N102AE" part="chapter3" ref="N102AE" type="subsection">3.1.1</cms:entry><cms:entry id="N102B7" part="chapter3" ref="N102B7" type="subsection">3.1.2</cms:entry><cms:entry id="N102BD" part="chapter3" ref="N102BD" type="subsection">3.1.3</cms:entry><cms:entry id="N102C6" part="chapter3" ref="N102C6" type="mm">574#432</cms:entry><cms:entry id="N102D6" part="chapter3" ref="N102D6" type="pagenumber">22</cms:entry><cms:entry id="N102DA" part="chapter3" ref="N102DA" type="mm">574#423</cms:entry><cms:entry id="N102E8" part="chapter3" ref="N102E8" type="mm">574#424</cms:entry><cms:entry id="N102F6" part="chapter3" ref="N102F6" type="pagenumber">23</cms:entry><cms:entry id="N102FA" part="chapter3" ref="N102FA" type="mm">575#426</cms:entry><cms:entry id="N10308" part="chapter3" ref="N10308" type="mm">575#432</cms:entry><cms:entry id="N10316" part="chapter3" ref="N10316" type="pagenumber">24</cms:entry><cms:entry id="N1031A" part="chapter3" ref="N1031A" type="mm">575#393</cms:entry><cms:entry id="N10328" part="chapter3" ref="N10328" type="mm">575#395</cms:entry><cms:entry id="N10333" part="chapter3" ref="N10333" type="section">3.2</cms:entry><cms:entry id="N10336" part="chapter3" ref="N10336" type="pagenumber">25</cms:entry><cms:entry id="N1033A" part="chapter3" ref="N1033A" type="subsection">3.2.1</cms:entry><cms:entry id="N1033D" part="chapter3" ref="N1033D" type="block">3.2.1.1</cms:entry><cms:entry id="N10343" part="chapter3" ref="N10343" type="block">3.2.1.2</cms:entry><cms:entry id="N10349" part="chapter3" ref="N10349" type="block">3.2.1.3</cms:entry><cms:entry id="N10358" part="chapter3" ref="N10358" type="block">3.2.1.4</cms:entry><cms:entry id="N10367" part="chapter3" ref="N10367" type="block">3.2.1.5</cms:entry><cms:entry id="N10370" part="chapter3" ref="N10370" type="block">3.2.1.6</cms:entry><cms:entry id="N10379" part="chapter3" ref="N10379" type="pagenumber">26</cms:entry><cms:entry id="N1037D" part="chapter3" ref="N1037D" type="mm">585#680</cms:entry><cms:entry id="N1039A" part="chapter3" ref="N1039A" type="subsection">3.2.2</cms:entry><cms:entry id="N1039D" part="chapter3" ref="N1039D" type="pagenumber">27</cms:entry><cms:entry id="N103A1" part="chapter3" ref="N103A1" type="block">3.2.2.1</cms:entry><cms:entry id="N103A7" part="chapter3" ref="N103A7" type="block">3.2.2.2</cms:entry><cms:entry id="N103B6" part="chapter3" ref="N103B6" type="mm">586#253</cms:entry><cms:entry id="N103D0" part="chapter3" ref="N103D0" type="block">3.2.2.3</cms:entry><cms:entry id="N103D3" part="chapter3" ref="N103D3" type="pagenumber">28</cms:entry><cms:entry id="N103DA" part="chapter3" ref="N103DA" type="block">3.2.2.4</cms:entry><cms:entry id="N103E3" part="chapter3" ref="N103E3" type="mm">585#259</cms:entry><cms:entry id="N103FD" part="chapter3" ref="N103FD" type="subsection">3.2.3</cms:entry><cms:entry id="N10400" part="chapter3" ref="N10400" type="pagenumber">29</cms:entry><cms:entry id="N10404" part="chapter3" ref="N10404" type="block">3.2.3.1</cms:entry><cms:entry id="N10410" part="chapter3" ref="N10410" type="block">3.2.3.2</cms:entry><cms:entry id="N1041C" part="chapter3" ref="N1041C" type="block">3.2.3.3</cms:entry><cms:entry id="N10422" part="chapter3" ref="N10422" type="block">3.2.3.4</cms:entry><cms:entry id="N10428" part="chapter3" ref="N10428" type="block">3.2.3.5</cms:entry><cms:entry id="N1042E" part="chapter3" ref="N1042E" type="block">3.2.3.6</cms:entry><cms:entry id="N10437" part="chapter3" ref="N10437" type="pagenumber">30</cms:entry><cms:entry id="N1043B" part="chapter3" ref="N1043B" type="mm">585#701</cms:entry><cms:entry id="N10455" part="chapter3" ref="N10455" type="subsection">3.2.4</cms:entry><cms:entry id="N10458" part="chapter3" ref="N10458" type="pagenumber">31</cms:entry><cms:entry id="N1045C" part="chapter3" ref="N1045C" type="block">3.2.4.1</cms:entry><cms:entry id="N10462" part="chapter3" ref="N10462" type="block">3.2.4.2</cms:entry><cms:entry id="N10468" part="chapter3" ref="N10468" type="block">3.2.4.3</cms:entry><cms:entry id="N1046E" part="chapter3" ref="N1046E" type="block">3.2.4.4</cms:entry><cms:entry id="N10477" part="chapter3" ref="N10477" type="mm">571#340</cms:entry><cms:entry id="N10482" part="chapter3" ref="N10482" type="subsection">3.2.5</cms:entry><cms:entry id="N10485" part="chapter3" ref="N10485" type="pagenumber">32</cms:entry><cms:entry id="N1048F" part="chapter3" ref="N1048F" type="mm">585#719</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N1049F" part="chapter4" ref="N1049F" type="pagenumber">33</cms:entry><cms:entry id="N104B8" part="chapter4" ref="N104B8" type="pagenumber">34</cms:entry><cms:entry id="N104CE" part="chapter4" ref="N104CE" type="pagenumber">35</cms:entry><cms:entry id="N104E1" part="chapter4" ref="N104E1" type="pagenumber">36</cms:entry><cms:entry id="N104EE" part="chapter4" ref="N104EE" type="pagenumber">37</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N104F5" part="chapter5" ref="N104F5" type="pagenumber">38</cms:entry><cms:entry ref="N1050F" type="back"/><cms:entry id="N10511" part="N10511" ref="N10511" type="abbreviation">
            Abkürzungsverzeichnis</cms:entry><cms:entry id="N10515" part="N10511" ref="N10515" type="pagenumber">6</cms:entry><cms:entry id="N1051C" part="N10511" ref="N1051C" type="table"/><cms:entry id="N1097F" part="N10511" ref="N1097F" type="pagenumber">7</cms:entry><cms:entry id="N10985" part="N10985" ref="N10985" type="bibliography">
            Literaturverzeichnis</cms:entry><cms:entry id="N10989" part="N10985" ref="N10989" type="pagenumber">39</cms:entry><cms:entry id="N10A02" part="N10985" ref="N10A02" type="pagenumber">40</cms:entry><cms:entry id="N10A78" part="N10985" ref="N10A78" type="pagenumber">41</cms:entry><cms:entry id="N10AF7" part="N10985" ref="N10AF7" type="pagenumber">42</cms:entry><cms:entry id="N10B73" part="N10985" ref="N10B73" type="pagenumber">43</cms:entry><cms:entry id="N10BF7" part="N10985" ref="N10BF7" type="pagenumber">44</cms:entry><cms:entry id="N10C76" part="N10985" ref="N10C76" type="pagenumber">45</cms:entry><cms:entry id="N10CF5" part="N10985" ref="N10CF5" type="pagenumber">46</cms:entry><cms:entry ref="N10D61" type="acknowledgement">
            Danksagung</cms:entry><cms:entry ref="N10D65" type="pagenumber">47</cms:entry><cms:entry id="N10D94" part="N10D94" ref="N10D94" type="vita">
            Lebenslauf</cms:entry><cms:entry id="N10D98" part="N10D94" ref="N10D98" type="pagenumber">48</cms:entry><cms:entry id="N10D9F" part="N10D94" ref="N10D9F" type="table"/><cms:entry id="N10F58" part="N10D94" ref="N10F58" type="pagenumber">49</cms:entry><cms:entry id="N10F88" part="N10F88" ref="N10F88" type="declaration">
            Eidesstattliche Erklärung</cms:entry><cms:entry id="N10F8C" part="N10F88" ref="N10F8C" type="pagenumber">50</cms:entry><cms:entry part="N10D61" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><acknowledgement id="N10D61">
         <head>
            <pagenumber id="N10D65" label="47" numbering="arabic" start="47"/>Danksagung</head>
         <p>An erster Stelle danke ich meinem Doktorvater, Herrn Oberarzt Prof. Dr. med. <strong>Uwe Pleyer</strong>, Universitäts-Augenklinik Charité, für die Unter­stützung und seine starkes Interesse an diesem Projekt. Sein außerordentliches Fachwissen war mir bei der Planung und Umsetzung der Experimente sehr hilfreich. </p>
         <p>Mein spezieller Dank geht an Herrn Oberarzt Dr. med. <strong>Holger Baatz</strong>, Universitäts-Augenklinik Frankfurt am Main, der mich<strong/>nicht nur für die wissenschaftliche Arbeit im Fachgebiet der Augenheilkunde be­geisterte, son­dern sie auch stets mit persönlichem Engagement und Kompetenz begleitete und förderte. Jederzeit stand seine Tür für anstehende Fragen und kritische Diskussionen offen. </p>
         <p>Frau Dr. <strong>Regina Reszka</strong>, Leiterin der Arbeitsgruppe &#8222;Drug targeting&#8220; am Max-Delbrück-Zentrum für Molekulare Medizin in Berlin-Buch gilt mein besonderer Dank für ihr Entgegenkommen bei der Bereit­stellung der für die Liposomenherstellung notwendigen Apparaturen. </p>
         <p>In diesem Zusammenhang möchte ich Frau <strong>Jana Richter</strong> (MTA) danken, die mich mit großer Ge­duld und Sorgfalt in die technischen Details der Herstellung von Liposomen einführte. Desgleichen gilt mein Dank der <strong>Firma Boehringer-Mannheim</strong> für das freundliche Überlassen der für diese Studie notwendigen Menge Clodronat.</p>
         <p>Im Besonderen danke ich Frau <strong>Beate Edelmann</strong> und allen Mitarbeitern des Forschungslabors der Augenklinik Charité (Ziegelstrasse 9) für die hilfreiche Unterstützung meiner Arbeit und die angenehme Zusammenarbeit. </p>
         <p>Herr Prof. Dr. Dr.(F) <strong>Christian Hartmann</strong> schließlich versteht es als Direktor der Klinik und Poli­klinik für Augenheilkunde der Charité, jene Möglichkeiten zu schaffen, die für wissenschaftliches Arbeiten unab­dingbar sind. Sein beständiges Interesse gilt dabei sowohl der wissenschaftlichen Diskussion als auch seinen Mitarbeitern. Ihm sei an dieser Stelle ebenfalls herzlich gedankt.</p>
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