Literaturverzeichnis

¹  Lee, Y.-C., Simamora, P., Yalkowsky, S.H., Effect of Brij-78 on systemic delivery of insulin from an ocular device, J. Pharm. Sci. (1997) 86; 430-433

²  Dondeti, P., Zia, H., Needham, T.E., In vivo evaluation of spray formulations of human insulin for nasal delivery, Int. J. Pharm. (1995) 122; 91-105

³  Hussain, A.A., Al-Bayatti, A.A., Dakkuri, A., Okochi, K., Hussain, M.A., Testosterone 17 β N,N Dimethylglycinate Hydrochloride: a prodrug with a potential for nasal delivery of testosterone, J. Pharm. Sci. (2002) 91; 785-789

⁴  Illum, L., Watts, P., Fisher, A.N., Hinchcliffe, M., Norbury, H., Jabbal-Gill, I., Nankervis, R., Davis, S.S., Intranasal delivery of morphine, J. Pharmacol. Exp. Ther. (2002) 301; 391-400

⁵  Verhoef, J.C., Merkus, F.W.H.M., Nasal absorption enhancement: Relevance to nasal drug delivery, in: deBoer, A. G. (Hrsg.), Drug Absorption Enhancement, Harwood Academic Publisher, Chur, 1994, pp. 119-153

⁶  Thadikonda, K.P., Lau-Cam, C.A., Thadikonda, V.L., Theofanopoulos, V., Nasal delivery of atenolol and timolol in the rat and the effect of absorption enhancers, Drug Devel. Ind. Pharm. (1995) 21; 349-360

⁷  Furrer, P., Mayer, J.M., Plazonnet, B., Gurny, R., Ocular tolerance of absorption enhancers in ophthalmic preparations, AAPS Pharm. Sci. (2002) 4; 1-5

⁸  Sullivan, D.A., Wickham, L.A., Rocha, E.M., Krenzer, K.L., Sullivan, B.D., Steagull, R., Cermak, J.M., Dana, M.R., Ullman, M.D., Sato, E.H., Gao, J., Rocha, F.J., Ono, M., Silveira, L.A., Lambert, R.W., Kelleher, R.S., Tolls, D.B., Toda, I., Androgens and dry eye in Sjogrens’s syndrome, Ann. N. Y. Acad. Sci. (1999) 22; 312-324

⁹  Sullivan, D.A., Sullivan, B.D., Evans, J.E., Schirra, F., Yamagami, H., Liu, M., Richards, S.M., Suzuki, T., Schaumberg, D.A., Sullivan, R.M., Dana, M.R., Androgen deficiency, meibomian gland dysfunction and evaporative dry eye, Ann. N. Y. Acad. Sci. (2002) 966; 211-222

¹⁰  Haecker, R., Kämpfe, E., Mattern, C., Androgenic substitution for the ageing male by nasal administration of a precursor of testosterone, Symp. Healthy ageing of male, Genf, 1998

¹¹  Siefert, B., Einfluss von Cyclodextrin auf die Löslichkeit und okulare Verfügbarkeit von Pilocarpin-HCl bzw. Thalidomid, Dissertation, Humboldt-Universität zu Berlin, 1998

¹²  Hockwin, O., Biochemie des Auges, Ferdinand Enke Verlag, Stuttgart, 1985

¹³  Sarkar, M.A., Drug metabolism in the nasal mucosa, Pharm. Res. (1992) 9; 1-9

¹⁴  Mitra, A.K. (Ed.), Ophthalmic Drug Delivery Systems, Marcel Dekker, Inc., New York 1993

¹⁵  Loftssona, T., Järvinen, T., Cyclodextrins in ophthalmic drug delivery, Adv. Drug Del. Rev. (1999) 36; 59-79

¹⁶  Doane, M.G., Jensen, A.D., Dohlman, C.H., Penetration routes of topically applied eye medications, Am. J. Ophthalmol. (1978) 85; 383-386

¹⁷  Ahmed, I., Gokhale, R.D., Shah, M.V., Patton, T.F., Physicochemical determinants of drug diffusion across the conjunctiva, sclera and cornea, J. Pharm. Sci. (1987) 76; 583-586

¹⁸  Hämäläinen, K.M., Kananen, K., Auriola, S., Kontturi, K., Urtti, A., Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva and sclera, Invest. Ophthalmol. Vis. Sci. (1997) 38; 627-634

¹⁹  Huang, A.J.W., Tseng, S.C.G., Kenyon, K.R., Paracellular permeability of corneal and conjunctival epithelia, Invest. Ophthalmol. Vis. Sci. (1989) 30; 684-689

²⁰  Dilly, P.N., Guillon, M., McGrogan, L., Video Biomicroscopy of the tear film, Adv. Exp. Med. Biol. (1998) 438; 737-743

²¹  Sharma, A., Breakup and dewetting of the corneal mucus layer, Adv. Exp. Med. Biol. (1998) 438; 273-280

²²  Tiffany, J.M., The Lipid Secretion of the Meibomian Glands, Adv. Lipid. Res. (1987) 22; 1-62

²³  Mishima, S., Nagataki, S., Conrad Berens memorial lecture: Pharmacology of ophthalmic solutions, Contact Lens (1978) 4; 22-46

²⁴  Mishima, S., Gasset, A., Klyce, S.D.Jr., Baum, J.L., Determination of tear volume and tear flow, Invest. Ophthalmol. (1966) 5; 264-276

²⁵  Nagyova, B., Tiffany, J.M., Components responsible for the surface tension of human tears, Current Eye. Res. (1999) 19; 4-11

²⁶  Kumar, G.N., Drug metabolizing enzyme systems in the eye, in: Reddy, I.K., (Ed.), Ocular Therapeutics and Drug Delivery, Technomic Pub. Comp. Inc., Lancaster/ Basel, 1996, pp. 149-167

²⁷  Illum, L., Nasal Delivery. The use of animal models to predict performance in man, J. Drug Target. (1996) 3; 427-442

²⁸  Cornaz, A.-L., Buri, P., Nasal mucosa as an absorption barrier, Eur. J. Phar. Biopharm. (1994) 40; 261-270

²⁹  Gizurarson, S., Animal models for intranasal drug delivery studies, Acta Pharm. Nord. (1990) 2; 105-122

³⁰  Narawane, L., Lee, V.H.L., Absorption barriers, in: deBoer, A.G. (Ed.), Drug Absorption Enhancement, Harwood Academic Publisher, Chur, 1994, pp. 3-5

³¹  Behl, C.R., Pimplaskar, H.K., Sileno, A.P., deMeireles, J., Romeo, V.D., Effects of physicochemical properties and other factors on systemic nasal drug delivery, Adv. Drug Del. Rev. (1998) 29; 89-116

³²  Sakane, T., Akizuki, M., Yoshida, M., Yamashita, S., Nadai, T., Hashida, M., Sezaki, H., Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity, J. Pharm. Pharmacol. (1991) 43; 449-451

³³  Sakane, T., Akizuki, M., Taki, Y., Yamashita, S., Sezaki, H., Nadai, T., Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the molecular weight of drugs, J. Pharm. Pharmacol. (1995) 47; 379-381

³⁴  Muchtar, S., Abdulrazik, M., Frucht-Pery, J., Benita, S., Ex-vivo study of indomethacin from a submicron emulsion through albino rabbit cornea, J. Control. Rel. (1997) 44; 55-64

³⁵  Waga, J., Ehinger, B., Passage of drugs through different intraocular microdialysis membranes, Arch. Clin. Exp. Ophthalmol. (1995) 233; 31-37

³⁶  Keipert, S., Ophthalmika, etablierte Arzneiformen und neue Konzepte, in: Müller, R.H., Hildebrand, G.E., (Hrsg.), Pharmazeutische Technologie - Moderne Arzneiformen, Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, 1998; pp. 77-98

³⁷  Williams, A.C., Barry, B.W., Skin absorption enhancers, Crit. Rev. Ther. Drug Carrier Sys. (1992) 9; 305-353

³⁸  Agarwal, V., Mishra, B., Recent trends in drug delivery systems: intranasal drug delivery, Ind. J. Exp. Biol. (1999) 37; 6-16

³⁹  Maitani, Y., Ishigaki, K., Takayama, K., Nagai, T., In vitro nasal transport across rabbit mucosa: effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17 β -estradiol, Int. J. Pharm. (1997) 146; 11-19

⁴⁰  Grass, G.M., Robinson, J.R., Mechanism of corneal drug penetration I: In vivo and in vitro kinetics, J. Pharm. Sci. (1988) 77; 3-14

⁴¹  Dua, R., Zia, H., Needham, T., The influence of tonicity and viscosity on the intranasal absorption of salmon calcitonin in rabbits, Int. J. Pharm. (1997) 147; 233-242

⁴²  Ohwaki, T., Ando, H., Watanabe, S., Miyake, Y., Effects of dose, pH and osmolarity on nasal absorption of secretin in rats, J. Pharm. Sci. (1985) 74; 550-552

⁴³  Schoenwald, R.D., Ward, R.L., Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients, J. Pharm. Sci. (1978) 67; 786-788

⁴⁴  Corbo, D.C., Liu, J.-C., Chien, Y.W., Characterization of the barrier properties of mucosal membranes, J. Pharm. Sci. (1990) 79; 202-206

⁴⁵  Merck & Co Inc., Whitehouse Station, 1996

⁴⁶  Forth, W., Henschler, D., Rummel, W., Starke, K., Allgemeine und spezielle Pharmakologie und Toxikologie, 7. Auflage, Spektrum akademischer Verlag, Heidelberg/ Berlin/ Oxford, 1996, pp. 596-598

⁴⁷  Wolf, E., Adam hat PADAM, Pharmazeutische Zeitung (2000) 145; 11-17

⁴⁸  Tukker, J.J., Ussing chamber to study active transport, Kurz-Vortrag, 3rd International intensive course and workshop on cell culture and other alternative methods for drug delivery research, Feb./März 2000, Saarbrücken

⁴⁹  Hosoya, K.-I., Kubo, H., Natsume, H., Sugibayashi, K., Morimoto, Y., Yamashita, S., The structural barrier of absorptive mucosae: site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits, Biopharm. Drug Dispo. (1993) 14; 685-696

⁵⁰  Miyamoto, M., Natsume, H., Iwata, S., Ohtake, K., Yamaguchi, M., Kobayashi, D., Sugibayashi, K., Yamashina, M., Morimoto, Y., Improved nasal absorption of drugs using poly-L-arginine: effects of concentration and molecular weight of poly-L-arginine on the nasal absorption of fluorescein isothiocyanate-dextran in rats, Eur. J. Phar. Biopharm. (2001) 52; 21-30

⁵¹  Cremophor® EL, Technisches Merkblatt, BASF, 1987

⁵²  Brewster, M.E., Anderson, W.R., Loftsson, T., Huang, M.-J., Bodor, N., Pop, E., Preparation, characterization and anesthetic properties of 2 hydroxypropyl- β -cyclo dextrin complexes of pregnanolone and pregnenolone in rat and mouse, J. Pharm. Sci. (1995) 84;1154-1159

⁵³  Rajewski, R.A., Stella, V.J., Pharmaceutical application of cyclodextrins. 2. In vivo drug delivery, J. Pharm. Sci. (1996) 85; 1142-1169

⁵⁴  Merkus, F.W.H.M., Verhoef, J.C., Marttin, E., Romeijn, S.G., van der Kuy, P.H.M., Hermens, W.A.J.J., Schipper, N.G.M., Cyclodextrins in nasal drug delivery, Adv. Drug Del. (1999) 36; 41-57

⁵⁵  Irie, T., Uekama, K., Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation, J. Pharm. Sci. (1997) 86; 147-162

⁵⁶  Loftsson, T., Brewster, M.E., Pharmaceutical application of cyclodextrins: 1. Drug solubilization and stabilization, J. Pharm. Sci. (1996) 85; 1017-1025

⁵⁷  Aktas, Y., Unlu, N., Orhan, M., Irkec, M., Hincal, A.A., Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine, Drug Dev. Ind. Pharm. (2003) 29; 223-230

⁵⁸  Vollmer, U., Müller, B.W., Peeters, J., Mesens, J., Wilffert, B., Peters, T., A study of the percutaneous absorption-enhancing effects of cyclodextrin derivatives in rats, J. Pharm. Pharmacol. (1994) 46; 19-22

⁵⁹  Shaker, D.S., Ghanem, A.-H., Li, S.K., Warner, K.S., Hashem, F.M., Higuchi, W.I., Mechanistic studies of the effect of hydroxypropyl- β -cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin, Int. J. Pharm. (2003) 253; 1-11

⁶⁰  Constantinides, P.P., Scalart, J.-P., Formulation and physical characterization of water-in-oil microemulsions containing long- versus medium-chain glycerides, Int. J. Pharm. (1997) 158; 57-68

⁶¹  Keipert, S., Siebenbrodt, I., Lüders, F., Bornschein, M., Mikroemulsionen und ihre potentielle pharmazeutische Nutzung, Pharmazie (1989) 44; 433-444

⁶²  Müller, B.W., Topische Mikroemulsionen als neue Wirkstoff-Trägersysteme, in: Müller, R.H., Hildebrand, G.E., (Hrsg.), Pharmazeutische Technologie–Moderne Arzneiformen, Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, 1998; pp. 109-116

⁶³  Zimmer, A., Attwood, D., Mikroemulsionen in: Herzfeldt, C.-D., Kreuter, J. (Hrsg.), Grundlagen der Arzneiformenlehre – Galenik 2, Springer Verlag, Berlin/ Heidelberg, 1999; pp. 190-203

⁶⁴  Gasco, M.R., Gallarate M., Trotta M., Bauchiero L., Gremmo E., Chiappero O., Microemulsions as topical delivery vehicles: ocular administration of timolol, J. Pharm. Biomed. Anal. (1989) 7; 433-439

⁶⁵  Bauchiero, L., Gremmo, E., Chiappero, O., Gasco, M.R., Gallarate, M., Trotta, M., Microemulsions as ophthalmic vehicles: studies on the release of timoptol, New Trends Ophthalmol. (1987) II; 377-379

⁶⁶  Radomska, A., Dobrucki, R., The use of some ingredients for microemulsion preparation containing retinol and its esters, Int. J. Pharm. (2000) 196; 131-134

⁶⁷  Vandamme, Th. F., Microemulsions as ocular drug delivery systems: recent developments and futur challenges, Prog. Retin. Eye Res. (2002) 21; 15-34

⁶⁸  Li, L., Nandi, I., Kim, K.H., Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam, Int. J. Pharm. (2002) 237; 77-85

⁶⁹  Haße, A., Entwicklung, Charakterisierung und Strukturuntersuchungen von tensidhaltigen Mehrkomponentensystemen zur okularen Anwendung, Dissertation, Humboldt-Universität zu Berlin, 1996

⁷⁰  Berndt, S., Entwicklung und Charakterisierung galenischer Formulierungen zur potentiellen nasalen Anwendung von Androstendion und Levodopa, Dissertation Humboldt-Universität zu Berlin, 2000

⁷¹  Dalmora, M.E.A., Oliveira, A.G., Inclusion complex of piroxicam with β -cyclodextrin and incorporation in hexadecyltrimethylammonium bromide based microemulsion, Int. J. Pharm. (1999) 184; 157-164

⁷²  Dalmora, M.E., Dalmora, S.L., Oliveira, A.G., Inclusion complex of piroxicam with β -cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect, Int. J. Pharm. (2001) 222; 45-55

⁷³  Maldonado, M.B., Lawrence, M.J., The incorporation of salicylic acid-dimethyl- β -cyclodextrin complex into water-in-oil microemulsions, J. Pharm. Pharmacol. (1998) 50, Suppl.; 177

⁷⁴  Singh, A.K., Kasinath, B.S., Lewis, E.J., Interaction of polycations with cell-surface negative charges of epithelial cells, Biochim. Biophys. Acta (1992) 1120; 337-342

⁷⁵  McEwan, G.T.A., Jepson, M.A., Hirst, B.H., Simmons, N.L., Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics, Biochim. Biophys. Acta (1993) 1148; 51-60

⁷⁶  Benita, S., Prevention of topical and ocular oxidative stress by positively charged submicron emulsion, Biomed. Pharmacother. (1999) 53; 193-206

⁷⁷  Klang, S., Abdulrazik, M., Benita, S., Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution, Pharm. Dev. Technol. (2000) 5; 521-32

⁷⁸  Müller, B.W., Kleinebudde, P., Untersuchungen an sogenannten Mikroemulsions-systemen, Pharm. Ind. (1988) 50; 370-375

⁷⁹  Trotta, M., Gasco, M.R., Pattarino, F., Effect of alcohol cosurfactants on the diffusion coefficients of microemulsions by light scattering, J. Disp. Sci. Tech. (1989) 10; 15-32

⁸⁰  Caputo, F.E., Burghardt, W.R., Krishnan, K., Bates, F.S., Lodge, T.P., Time-resolved small-angle x-ray scattering measurements of a polymer bicontinuous microemulsion structure factor under shear, Phys. Rev. (2002) 66; 1-17

⁸¹  Müller, B.W., Müller, R.H., Particle size distributions and particle size alterations in microemulsions, J. Pharm. Sci. (1984) 73; 919-922

⁸²  Keipert, S., Schulz, G., Mikroemulsionen auf Saccharoseesterbasis, Pharmazie (1994) 49; 195-197

⁸³  Moreno, M.A., Frutos, P., Ballesteros, M.P., Lyophilized lecithin based oil-water microemulsions as a new and low toxic delivery system for amphotericin B, Pharm. Res. (2001) 18; 344-351

⁸⁴  Paul, B.K., Moulik, S.P., Microemulsions: an overview, J. Disp. Sci. Tech. (1997) 18; 301-367

⁸⁵  Kielhorn, E., Bestimmung von Mischungswärmen tensidhaltiger Mehr komponenten systeme mittels der Dynamischen Differenz-Kalorimetrie, Diplomarbeit, Humboldt-Universität zu Berlin, 1997

⁸⁶  Alami, E., Abrahmsen-Alami, S., Eastoe, J., Grillo, I., Heenan, R.K., Interactions between a nonionic surfactant and cyclodextrins investigated by small-angle neutron scattering, J. Colloid. Interface Sci. (2002) 255; 403-409

⁸⁷  Leuenberger, H. (Hrsg.), Martin, Physikalische Pharmazie, Wissenschaftliche Verlags gesellschaft mbH, Stuttgart, 2002

⁸⁸  Rosano, H.L., Lyons, G.B., Free energy, enthalpy and entropy changes during the formation of a n-hexadecane/ potassium stearate/ water/ 1-pentanol microemulsion system, J. Chem. Phys. (1985) 89; 363-365

⁸⁹  Kaler, E.W., Bennett, K.E., Davis, H.T., Scriven, L.E., Toward understanding microemulsion microstructure: a small-angle X-ray scattering study, J. Chem. Phys. (1983) 79; 5673

⁹⁰  Teubner, M., Strey, R., Origin of the scattering peak in microemulsions, J. Chem. Phys. (1987) 87; 3195-3200

⁹¹  Würz, U., Small angle X-ray scattering of microemulsions, Progr. Colloid. Polym. Sci. (1988) 76; 153-158

⁹²  Ezrahi, S., Wachtel, E., Aserin, A., Garti, N., Structural polymorphism in a four-component nonionic microemulsion, J. Colloid. Inter. Sci. (1997) 191; 277-290

⁹³  Seto, H., Okuhara, D., Kawabata, Y., Takeda, T., Nagao, M., Suzuki, J., Kamikubo, H., Amemiya, Y., Pressure and temperature effects on the phase transition from a dense droplet to a lamellar structure in a ternary microemulsion, J. Chem. Phys. (2000) 112; 10608-10614

⁹⁴  Peltola, S., Saarinen-Savolainen, P., Kiesvaara, J., Suhonen, T.M., Urtti, A., Microemulsions for topical delivery of estradiol, Int. J. Pharm. (2003) 254; 99-107

⁹⁵  Sullivan, D.A., Sullivan, B.D., Ullman, M.D., Rocha, E.M., Krenzer, K.L., Cermak, J.M., Toda, I., Doane, M.G., Evans, J.E., Wickham, L.A., Androgen influence on the meibomian gland, Invest. Ophthalmol. Vis. Sci. (2000) 41; 3732-3742

⁹⁶  Szejtli, J., Davies, J.E.D., Cyclodextrin technology, Kluver Academic Publishers, Dordrecht-Boston-London, 1988

⁹⁷  Keipert, S., Fedder, J., Böhm, A., Hanke, B., Interactions between cyclodextrins and pilocarpin – as an example of a hydrophilic drug, Int. J. Pharm. (1996) 46; 355-360

⁹⁸  Higuchi, T., Connors, K.A., Advances in analytical chemistry and instrumentation, New York Interscience, New York, 1965, pp. 128-131

⁹⁹  Albers, E., Müller, B.W., Complexation of steroid hormones with cyclodextrin derivatives: substituent effects of the guest molecule on solubility and stability in aqueous solution, J. Pharm. Sci. (1992) 81; 756-761

¹⁰⁰  Andersen, F.M., Bundgaard, H., The influence of β -cyclodextrin on the stability of hydrocortison in aqueous solution, Arch. Pharm. Chem. (1983) 11; 61-66

¹⁰¹  Masson, M., Loftsson, T., Masson, G., Stefansson, E., Cyclodextrins as permeation enhancers, J. Control. Rel. (1999) 59; 107-118

¹⁰²  Bary, A.R., Tucker, I.G., Davies, N.M., Considerations in the use of hydroxypropyl- β -cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortison, Eur. J. Phar. Biopharm. (2000) 50; 237-244

¹⁰³  Uekama, K., Hirayama, F., Irie, T., Application of cyclodextrins, in: deBoer, A.G. (Ed.), Drug Absorption Enhancement, Harwood Academic Publisher, Chur, 1994, pp. 411-456

¹⁰⁴  Grass, G.M., Robinson, J.R., Relationship of chemical structure to corneal penetration and influence of low-viscosity solution on ocular bioavailability, J. Pharm. Sci. (1984) 73; 1021-1027

¹⁰⁵  Sasaki, H., Ichikawa, M., Yamamura, K., Nishida, K., Nakamura, J., Ocular membrane permeability of hydrophilic drugs for ocular peptide delivery, J. Pharm. Pharmacol. (1997) 49; 135-139

¹⁰⁶  Chang, S.-C., Lee, V.H.L., Nasal and conjunctival contributions to the systemic absorption of topical timolol in the pigmented rabbit: implications in the design of strategies to maximize the ratio of ocular to systemic absorption, J. Ocul. Pharm. (1987) 3; 159-169

¹⁰⁷  Camber, O., An in vitro model for determination of drug permeability through the cornea, Acta Pharm. Suec. (1985) 22; 335-342

¹⁰⁸  Camber, O., Edman, P., Influence of some preservatives on the corneal permeability of pilocarpine and dexamethasone, in vitro, Int. J. Pharm. (1987) 39; 229-234

¹⁰⁹  Dittgen, M., Oestereich, S., Eckhardt, D., Influence of bioadhesion on the elimination of drugs from the eye and on their penetration ability across the pig cornea, S.T.P. Pharma Sciences (1992) 2; 93-97

¹¹⁰  Babiole, M., Wilhelm, F., Schoch, C., In vitro corneal permeation of unoprostone isopropyl (UI) and its metabolism in the isolated pig eye, J. Ocul. Pharmacol. Ther. (2001) 17; 159-172

¹¹¹  Scholz, M., Lin, J.E., Lee, V.H., Keipert, S., Pilocarpine permeability across ocular tissues and cell cultures: influence of formulation parameters, J. Ocul. Pharmacol. Ther. (2002) 18; 455-468

¹¹²  Lang, S.R., Staudenmann, W., James, P., Manz, H.-J., Kessler, R., Galli, B., Moser, H.-P., Rummelt, A., Merkle, H.P., Proteolysis of human calcitonin in excised bovine nasal mucosa: Elucidation of the metabolic pathway by liquid secondary ionization mass spectrometry (LSIMS) and matrix assisted laser desorption ionization mass spectrometry (MALDI), Pharm. Res. (1996) 13; 1679-1685

¹¹³  Schmidt, M.C., Peter, H., Lang, S.R., Ditzinger, G., Merkle, H.P., In vitro cell models to study nasal mucosal permeability and metabolism, Adv. Drug Del. Rev. (1998) 29; 51-79

¹¹⁴  Schmidt, M.C., Simmen, D., Hilbe, M., Boderke, P., Ditzinger, G., Sandow, J., Lang, S., Rubas, W., Merkle, H.P., Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium, J. Pharm. Sci. (2000) 89; 396-407

¹¹⁵  Schmidt, M.C., Rubas, W., Merkle, H.P., Nasal epithelial permeation of thymotrinan (TP3) versus thymocartin (TP4): competitive metabolism and self-enhancement, Pharm. Res. (2000) 17; 222-228

¹¹⁶  Östh, K., Grasjö, J., Björk, E., A new method for drug transport studies on pig nasal mucosa using a horizontal ussing chamber, J. Pharm. Sci. (2002) 91; 1256-1273

¹¹⁷  Östh, K., Paulsson, M., Björk, E., Edsman, K., Evaluation of drug release from gels on pig nasal mucosa in a horizontal Ussing chamber, J. Control. Rel. (2002) 83; 377

¹¹⁸  Wadell, C., Björk, E., Camber, O., Permeability of porcine nasal mucosa correlated with human nasal absorption, Eur. J. Pharm. Sci. (2003) 18; 47-53

¹¹⁹  Benson, H., Permeability of the cornea to topically applied drugs, Arch. Ophthalmol. (1974) 91; 313-327

¹²⁰  Hull, D.S., Hine, J.E., Edelhauser, H.F., Hyndiuk, R.A., Permeability of the isolated rabbit cornea to corticosteroids, Invest. Ophthalmol. (1974) 13; 457-459

¹²¹  Saettone, M.F., Chetoni, P., Cerbai, R., Mazzanti, G., Braghiroli, L., Evaluation of ocular permeation enhancers: in vitro effects on corneal transport of four β -blockers, and in vitro/in vivo toxic activity, Int. J. Pharm. (1996) 142; 103-113

¹²²  Frederiksen, O., Röpke, M., Hansen, M., Carstens, S., Holm, M., Christensen, P., Colding-Jorgensen, M., Danielsen, G., Phospholipid-induced changes in ion transport pathways of the rabbit nasal mucosa in vitro, European Symposium APGI/FIP, Paris, 1993

¹²³  Bechgaard, E., Gizurarson, S., Jørgensen, L., Larsen, R., The viability of isolated rabbit nasal mucosa in the Ussing chamber, and permeability of insulin across the membrane, Int. J. Pharm. (1992) 87; 125-132

¹²⁴  Siefert, B., Keipert, S ., Influence of α -cyclodextrin and hydroxyalkylated β -cyclodextrin derivatives on the in vitro corneal uptake and permeation of aqueous pilocarpine-HCl solutions, J. Pharm. Sci. (1997) 86, 716-720

¹²⁵  Ammar, H.O., El-Nahhas, S.A., Khalil, R.M., Cyclodextrins in acetazolamide eye drop formulations, Pharmazie (1998) 53; 559-562

¹²⁶  Rajewski, R.A., Stella, V.J., Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery, J. Pharm. Sci. (1996) 85; 1142-1169

¹²⁷  Hosoya, K.-I., Kubo, H., Natsume, H., Sugibayashi, K., Morimoto, Y., Evaluation of enhancers to increase nasal absorption using Ussing chamber technique, Biol. Pharm. Bull. (1994) 17; 316-322

¹²⁸  Shao, Z., Krishnamoorthy, R., Mitra, A.K., Cyclodextrins as nasal absorption promotors of insulin: mechanistic evaluations, Pharm. Res. (1992) 9; 1157-1163

¹²⁹  Marttin, E., Verhoef, J.C., Romeijn, S.G., Merkus, F.W.H.M., Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity, Pharm. Res. (1995) 12; 1151-1157

¹³⁰  Marttin, E., Verhoef, J.C., Romeijn, S.G., Zwart, P., Merkus, F.W.H.M., Acute histopathological effects of benzalkonium chloride and absorption enhancers on rat nasal epithelium in vivo, Int. J. Pharm. (1996) 141; 151-160

¹³¹  Kristinsson, J.K., Fridriksdottir, H., Thorisdottir, S., Sigurdardottir, A.M., Stefansson, E., Loftsson, T., Dexamethasone-cyclodextrin-polymer co-complexes in aqueous eye drops, Invest. Ophthalmol. Vis. Sci. (1996) 37; 1199-1203

¹³²  Hochman, J., Artursson, P., Mechanism of absorption enhancement and tight junction regulation, J. Control. Rel. (1994) 29; 256-267

¹³³  Leszczynski, D.E., Schafer, R.M., Characterization of steroid hormone association with human plasma lipoproteins, Steroids (1989) 54; 37-53

¹³⁴  Prausnitz, M.R., Noonan, J.S., Permeability of cornea, sclera and conjunctiva: a literature analysis for drug delivery to the eye, J. Pharm. Sci. (1998) 87; 1479-1488

¹³⁵  Brittebo, E.B., Rafter, J.J., Steroid metabolism by rat nasal mucosa: studies on progesterone and testosterone, J. Steroid. Biochem. (1984) 20; 1147-1151

¹³⁶  Southren, A.L., Altman, K., Vittek, J., Boniuk, V., Gordon, G.G., Steroid metabolism in ocular tissues of the rabbit, Invest. Ophthalmol. (1976) 15; 222-228

¹³⁷  Starka, L., Obenberger, J., Testosterone metabolism in various tissues of the intact and inflamed rabbit eye, Ophthal. Res. (1976) 8; 374-378

¹³⁸  Ploc, I., Sulcova, J., Starka, L., Androgen metabolism in the epithelium of the bovine cornea, Endokrinol. (1978) 72; 237-333

¹³⁹  Donovan, M.D., Flynn, G.L., Amidon, G.L., Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption, Pharm. Res. (1990) 7; 863-868

¹⁴⁰  Hirai, S., Yashiki, T., Matsuzawa, T., Mima, H., Absorption of drugs from the nasal mucosa of rat, Int. J. Pharm. (1981) 7; 317-325

¹⁴¹  Grass, G.M., Wood, R.W., Robinson, J.R., Effects of calcium chelating agents on corneal permeability, Invest. Ophthalmol. Vis. Sci. (1985) 26; 110-113

¹⁴²  Grass, G.M., Robinson, J.R., Mechanisms of corneal drug penetration II: Ultrastructural analysis of potential pathways for drug movement, J. Pharm. Sci. (1988) 77; 15-23

¹⁴³  Schoenwald, R.D., Huang, H.-S., Corneal penetration behaviour of β -blocking agents I: Physicochemical factors, J. Pharm. Sci. (1983) 72; 1266-1271

¹⁴⁴  Hornof, M.D., Bernkop-Schnürch, A., In vitro evaluation of the permeation enhancing effect of polycarbophil-cystein conjugates on the cornea of rabbits, J. Pharm. Sci. (2002) 91; 2588-2592

¹⁴⁵  Nishijo, J., Tsuchitani, M., Interaction of L-tryptophan with α -cyclodextrin: studies with calorimetry and proton nuclear magnetic resonance spectroscopy, J. Pharm. Sci. (2001) 90; 134-140

¹⁴⁶  []Marttin, E., Verhoef, J.C., Spies, F., van der Meulen, J., Nagelkerke, J.F., Koerten, H.K., Merkus, F.W.H.M., The effect of methylated β -cyclodextrins on the tight junctions of the rat nasal respiratory epithelium: electron microscopic and confocal laser scanning microscopic visualization studies, J. Pharm. Sci. (1999) 57; 205-213

¹⁴⁷  Gaskonda, V.R., Khan, M.A., Hutak, C.M., Reddy, I.K., Permeability characteristics of novel mydriatic agents using an in vitro cell culture model that utilizes sirc rabbit corneal cells, J. Pharm. Sci. (1999) 88; 180-184

¹⁴⁸  Bach, M., Lippold, B.C., Percutaneous penetration enhancement and its quantification, Eur. J. Phar. Biopharm. (1998) 46; 1-13

¹⁴⁹  Hussain, A.A., Intranasal drug delivery, Adv. Drug Del. Rev. (1998) 29; 39-49

¹⁵⁰  Stratford jr., R.E. and Lee, V.H.L., Aminopeptidase activity in homogenates of various absorptive mucosae in the albino rabbit: implications in peptide delivery, Int. J. Pharm. (1986) 30; 73-82

¹⁵¹  Koolman, J., Röhm, K.-H., Taschenatlas der Biochemie, Georg Thieme Verlag, Stuttgart/ New York, 1994

¹⁵²  Ko, K.-T., Needham, T.E., Zia, H., Emulsion formulations of testosterone for nasal administration, J. Microencapsulation (1998) 15; 197-205

¹⁵³  Shackleton, C.H.L., Whitney, J.O., Use of Sep-pak ^® cartridges for urinary steroid extraction: evaluation of the method for use prior to gas chromatographic analysis, Clin. Chim. Acta (1980) 107; 231-243

¹⁵⁴  Andersson, S.H.G., Cronholm, T., Sjövall, J., Effects of ethanol on the levels of unconjugated and conjugated androgens and estrogens in plasma of men, J. Steroid. Biochem. (1986) 24; 1193-1198

¹⁵⁵  Stuenkel, C.A., Dudley, R.E., Yen, S.S.C., Sublingual administration of testosterone-hydroxypropyl- β -cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men, J. Clin. Endocrin. Metabol. (1991) 72; 1054-1059

¹⁵⁶  Hussain, A.A., Kimura, R., Huang, C.H., Nasal absorption of testosterone in rats, J. Pharm. Sci. (1984) 73; 1300-1301

¹⁵⁷  Bron, A.J., Tiffany, J.M., The meibomian glands and tear film lipids, Adv. Exp. Med. Biol. (1998) 438; 281-295

¹⁵⁸  Kaercher, T., Möbius, D., Jaeger, W., Schichtdickenbestimmung des Sekrets Meibom scher Drüsen unter in vitro-Bedingungen, Fortschr. Ophthalmol. (1986) 83; 90-94

¹⁵⁹  Hart, W.M. (Ed.), Adler’s Physiology of the Eye, Mosby Year Book, Inc., St. Louis, 1992

¹⁶⁰  Shimazaki, J., Sakata, M., Tsubota, K., Ocular surface changes and discomfort in patients with meibomian gland dysfunction, Arch. Ophthalmol. (1995) 113; 1266-1270

¹⁶¹  Krenzer, K.L., Dana, M.R., Ullman, M.D., Cermak, J.M., Tolls, D.B., Evans, J.E., Sullivan, D.A., Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface, J. Clin. Endocrin. Metabol. (2000) 85; 4874-4882

¹⁶²  McCulley, J.P., Shine, W., A compositional based model for the tear film lipid layer, Trans. Am. Ophthalmol. Soc. (1997) 95; 79-88

¹⁶³  McCulley, J.P., Shine, W.E., The lipid layer: the outer surface of the ocular surface tear film, Biosci. Rep. (2001) 21; 407-418

¹⁶⁴  Kawaguchi, S., Studies on the precorneal film with measurement of monomolecular surface pressure, Fol. Ophthalmol. Jpn. (1967) 18; 283-289

¹⁶⁵  Jaeger, W., Möbius, D., Kaercher, T., In: Holly, F.J., (Ed.), The Preocular Tear Film in Health, Disease and Contact Lens Wear. Lubbock, TX: Dry Eye Institute, 1986, pp. 609-621

¹⁶⁶  Jaeger, W., Möbius, D., Kaercher, T., Biophysikalische experimentelle Unter suchungen über die Stabilität und Flexibilität der Lipidschicht des Tränenfilms unter Bedingungen der Kompression und Spreitung, Fortschr. Ophthalmol. (1986) 83; 86-89

¹⁶⁷  Kaercher, T., Möbius, D., Stabilität und Flexibilität der Lipidschicht des Tränenfilms sowie deren pathologischer Veränderungen im biophysikalischen Experiment, Fortschr. Ophthalmol. (1989) 86; 245-248

¹⁶⁸  Kaercher, T., Möbius, D., Welt, R., Biophysical characteristics of the Meibomian lipid layer under in vitro conditions, Int. Ophthalmol. (1992) 16; 167-176

¹⁶⁹  Kaercher, T., Möbius, D., Welt, R., Biophysical behaviour of the infant Meibomian lipid layer, Int. Ophthalmol. (1994) 18; 15-19

¹⁷⁰  Kaercher, T., Hönig, D., Möbius, D., Brewster angle microscopy, A new method of visualizing the spreading of Meibomian lipids, Int. Ophthalmol. (1993) 17; 341-348

¹⁷¹  Kaercher, T., Hönig, D., Möbius, D., Meibomian lipid layers seen through BAM, Orbit (1995) 14; 17-24

¹⁷²  Kaercher, T., Hönig, D., Möbius, D., Welt, R., Morphologie des Meibom-Lipidfilms, Ophthalmologe (1995) 92; 12-16

¹⁷³  Kim, J., Levitsky, I.A., McQuade, D.T., Swager, T.M., Structural control in thin layers of poly(p-phenyleneethynylene)s: photophysical studies of Langmuir and Langmuir-Blodgett films, J. Am. Chem. Soc. (2002) 124; 7710-7718

¹⁷⁴  Glasgow, B.J., Marshall, G., Gasymov, O.K., Abduragimov, A.R., Yusifov, T.N., Knobler, C.M., Tear lipocalins: potential lipid scavengers for the corneal surface, Invest. Ophthalmol. Vis. Sci. (1999) 40; 3100-3107

¹⁷⁵  Vollhardt, D., Fainermann, V.B., Penetration of dissolved amphiphiles into two-dimensional aggregating lipid monolayers, Adv. Colloid. Interface Sci. (2000) 86; 103-151

¹⁷⁶  Stella, V.J., Rajewski, R.A., Cyclodextrins: Their future in drug formulation and delivery, Pharm. Res. (1997) 14; 556-567

¹⁷⁷  Müller, B.W., Brauns, U., Hydroxypropyl- β -cyclodextrin derivatives: influence of average degree of substitution on complexing ability and surface activity, J. Pharm. Sci. (1986) 75; 571-572

¹⁷⁸  Zia, V., Rajewski, R.A., Bornancini, E.R., Luna, E.A., Stella, V.J., Effect of alkyl chain length and degree of substitution on the complexation of sulfoalkyl ether β -cyclodextrins with steroids, J. Pharm. Sci. (1997) 86; 220-224

¹⁷⁹  DeGrip, W.J., VanOostrum, J., Bovee-Geurts, P.H.M., Selective detergent-extraction from mixed detergent/lipid/protein micelles, using cyclodextrin inclusion compounds: a novel approach for the preparation of proteoliposomes, Biochem. J. (1998) 330; 667-674

¹⁸⁰  Topchieva, I.I., Karezin, K., Self-assembled supramolecular micellar structures based on non-ionic surfactants and cyclodextrins, J. Colloid. Interface Sci. (1999) 213; 29-35

¹⁸¹  Jabbal Gill, I., Fisher, A.N., Hinchcliffe, M., Whetstone, J., Farraj, N., DePonti, R., Illum, L., Cyclodextrins as protection agents against enhancer damage in nasal delivery systems II. Effect on in vivo absorption of insulin and histopathology of nasal membrane, Eur. J. Pharm. Sci. (1994) 1; 237-248

¹⁸²  Goto, E., Shimazaki, J., Monden, Y., Takano, Y., Yagi, Y., Shimmura, S., Tsubota, K., Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction, Ophthalmology (2002) 109; 2030-2035

¹⁸³  Francoeur, M., Ahmed, I., Sitek, S., Patton, T.F., Age-related differences in ophthalmic drug disposition III. Corneal permeability of pilocarpin in rabbits, Int. J. Pharm. (1983) 16; 203-213

¹⁸⁴  Boltri, L., Morel, S., Trotta, M., Gasco, M.R., In vitro transdermal permeation of nifedipin from thickened microemulsions, J. Pharm. Belg. (1994) 49; 315-320

¹⁸⁵  Bhatnagar, S., Vyas, S.P., Organogel-based system for transdermal delivery of propranolol, J. Microencapsulation (1994) 11; 431-438

¹⁸⁶  Schmalfuß, U., Neubert, R., Wohlrab, W., Modification of drug penetration into human skin using microemulsions, J. Controlled Rel. (1997) 46; 279-285

¹⁸⁷  Scholz, M., In vitro Permeationsstudien von hydrophilen und lipophilen Arzneistoffen an okularen Geweben und Zellkulturen, Dissertation, Humboldt-Universität zu Berlin, 2003

¹⁸⁸  Deutscher Apothekerverlag, Stuttgart, Govi-Verlag, Pharm. Verlag GmbH, Eschborn