Aigner et al. 1995 Aigner T, Dietz U, Stoss H, von der Mark K: Differential expression of collagen types I, II, III, and X in human osteophytes. Lab Invest 1995 Aug; 73(2):236-43

Aigner et al. 2001 Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L .: Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 2001 Dec; 44 (12):2777-89

Aigner et al. 2002 Aigner T, McKenna L.: Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 2002 Jan;59(1):5-18

Altman 1991 Altman RD: Classification of desease: Osteoarthritis. Semin Arthritis Rheum (Suppl2) 1991 ; 20: 40-47

Altman 1995 Altman RD: The classification of osteoarthritis. J Rheumatol 1995; 22:42-3

Altman et al. 1990 Altman A, Coggeshall KM and Mustelim T : Molecular events mediating T cell activation. Adv Immunol 1990 48,227

Athanasou et al. 1995 Athanasou NA: Synovial macrophages. Ann Rheum Dis 1995; 54: 392-394.

Barland 1962 Barland P, Novikoff AB, Hamerman D : Electron microscopy of the human synovial membrane. J Cell Biol 1962; 14:207-216.

Berek et al. 1985 Berek C, Grifriths GM, Milstein C.: Molecular events during maturation of the immune response to oxazolone. Nature 1985 Aug 16(6027):412-8

Berek 1992 Berek C.: The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol Rev 1992 Apr;126:5-19

Berek et al. 1997 Berek C, Kim HJ: B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis. Semin Immunol 1997 Aug; 9(4):261-8

Birk et al. 2001 Birk RW, Gratchev A, Hakiy N, Politz O, Schledzewski K, Guillot P, Orfanos CE, Goerdt S.: Alternative activation of antigen-presenting cells: concepts and clinical relevance. Hautarzt 2001 Mar; 52(3):193-200

Blanco et al. 1999 Blanco FJ, Guitián R, Varcía-Porrúa et al.: Osteoarthritis (OA) chondrocytes death by apoptosis: A possible pathway for OA pathologie. Arthritis Rheum 1999; 39(suppl): S269

Breedveld 1999 Breedveld FC : Future trends in the treatment of rheumatoid arthritis: cytokine targets. Rheumatol. 1999; 38(suppl.2):11-13

Buelens et al. 1995 Buelens C, Willems F, Delvaux A et al .: Interleukin 10 differentially regulates B7 (CD 80) and B7(CD 68) expressions on human peripheral blood dentritic cells. Eur J Immunol 1995; 29, 2668

Camacho et al. 1998 Camacho SA, Kosco-Vilbois MH, Berek C: The dynamic structure of human germinal centre. Immunol Today 1998; 19:511-514

Constant et al. 1997 Constant SL, Bottomly K.: Induction of Thl and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15:297-322

Cooke 1985 Cooke TDV : Pathogenetic mechanisms in polyarticular osteoarthritis . Clin Rheum Dis 1985 ; 11 : 203-238

Cooper et al. 1981 Cooper NS, Soren A, McEwen C, Rosenberger JL: Diagnostic specificity of synovial lesions. Hum Pathol 1981; 12:314-28

de Waal et al. 1991 De Waal MR, Abrams J, Bennet B, Figdor CG and EDV-J: Interleukin 10, (IL-10) inhibits cytokine synthesis by human monocytes and autoregulatory role of IL10 produced by monocytes. J Exp Med 1991; 174,1209

Dolganiuc et al. 1999 Dolganiuc A, Stavaru C, Anghel M, Georgescu E, Chichos B, Olineseu A.: Shift toward T lymphocytes with Thl and Tcl cytokine-secterion profile in the joints of patients with osteoarthritis. Roum Arch Microbiol Immunol 1999 Jul-Dec;58(3-4):249-58

Druihle und Pretolani 1998Druihle A, Pretolani M.: Eosinophila and interleukin 5: role in pulmonary atopic process. Med Trop 1998; 58 ( 4 ): 437-43

Fassbender 1987 Fassbender HG: Role of chondrocytes in the development of osteoarthritis. Am J Med 1987 Nov 20; 83(5A):17-24

Felsen et al. 1994 Felson DT, Radin EL: What causes knee osteoarthrosis: are different compartments susceptible to different risk factors ? J Rheumatol 1994; 21:81-183

Finkelman et al. 2001 Finkelman FD, Urban JF Jr : The other side of the coin: the protective role of the TH2 cytokines. J Allergy Clin Immunol 2001 May; 107(5):772-80

Fiorentio et al. 1989 Fiorentio DF, Bond MW, Mosmann TR: Two types of mouse helper cell clones Iv. TH2 clones secrete a factor that inhibits cytokine production by TH1 clones. J Exp Med 1989 170,2081

Fritz et al. 1981 Fritz P, Muller J, Wegner G, Laschner W, Braun U: Distribution of immunglobulin classes in joint capsules in osteoarthritis (arthrosis) and chronic polyarthritis. Z Rheumatol 1981; 40:187-194

Gerdes et al. 1983 Gerdes J, Schwab U, Lemke H, Stein H: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 1983 Jan 15; 31 (1):13-20

Goldenberg et al. 1982 Goldenberg DL, Egan MS, Cohen AS : Inflammatory synovitis in degenerative joint disease. J Rheumatol 1982 Mar-Apr; 9(2):204-9

Hoaglund & Steinbach 2001Hoaglund FT, Steinbach LS: Primary osteoarthritis of the hip: etiology and epidemiology. J Am Acad Orthop Surg 2001; 9 (5): 320-7

Holderbaum et al. 1999 Holderbaum D, Haqqi TM, Moskowitz RW : Genetics and osteoarthritis: exposing the iceberg. Arthritis Rheum 1999; 42:397-405.

Isomäki et al. 1996 Isomäki P, Luukkainen R, Toivanen P, Punnonen J: The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1996 Oct; 39(10):1693-702

Johnson et al. 1986 Johnson GD, Hardie DL, Ling NR, Maclennan IC: Human follicular dendritic cells (FDC): a study with monoclonal antibodies (MoAb). Clin Exp Immunol 1986 Apr; 64(1):205-13

Kennedy et al. 1988 Kennedy TD, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN: Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis. J Clin Pathol 1988 Aug; 41(8):847-52

Krenn et al. 1990 Krenn V, Hoffmann S, Engel A: First description of mechanoreceptors in the corpus adiposum infrapatellare of men. Acta Anat 1990 ; 137:187-189.

Krenn et al. 1996 Krenn V, Schalhorn N, Greiner A, Molitoris R, König A, Gohlke F, Müller-Hermelink HK: Immunohistochemical analysis of proliferating and antigen-presenting cells in rheumatoid synovial tissue. Rheumatol Int 1996; 15(6):239-47

Krenn et al. 1999a Krenn V, König A, Hensel F., Berek C, Souto Carneiro MM, Haedicke W, Wang YK, Vollmers HP, Müller-Hermelink HK: Molecular analysis of RF-negative B-cell hybridomas from rheumatoid synovial tissue: Evidence for an antigen-induced stimulation with selection of high mutated IgVH and low mutated IgVL/ l genes. Clin Exp Immunol 1999; 115 :168-175.

Krenn et al. 1999b Krenn V, Hensel F, Kim HJ, Souto Carneiro MM, Starostik P, Ristow G, König A, Vollmers HP, Müller-Hermelink HK: Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response. Lab Invest 1999 Nov; 79(11):1377-84

Kriegsmann et al. 1995 Kriegsmann J, Keyszer G, Geiler T, Brauer R, Gay R, Gay S: Expression of vascular cell adhesion molecule mRNA and protein in rheumatoid synovium demonstrated by in situ hybridisation and immunohistochemistry. Lab Invest 1995; 72: 209-214.

MacLennan 1994 MacLennan IC: Germinal Centers. Annu Rev Immunol 1994 12:117-139

Martel-Pelletier 1999 Martel-Pelletier J: Pathophysiology of osteoarthritis Osteoarthritis Cartilage 1999 Jul; 7(4): 371-3

Mellman et al. 2001 Mellman I, Steinman RM.: Dendritic cells: specialized and regulated antigen processing machines. Cell 2001 Aug 10; 106(3):255-8

Mohr 1993 Mohr W: Pathogenese der Arthrose - primäre Ereignisse und Folgen. Med Orthop Tech 1993; 113:54-58

Mohr 2000a Mohr W : Gelenkpathologie Springer 2000; 68-86

Mohr 2000b Mohr W: Gelenkpathologie Springer 2000; 418-439

Mohr et al. 1986 Mohr W: Pathomorphologic aspects of the conservative therapy of arthroses. Orthopade 1986 Sep; 15(5):366-78

Moos et al. 2001 Moos V, Sieper J, Herzog V, Müller B: Regulation of Expression oft Cytokines and Growth Factors in Osteoarthritic Cartilage Explants. Clin Rheumatol 2001 20:353-358

Mosmann et al. 1986 Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL : Two Types of murine helper T-cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986 Apr 1; 136 7:2348-57

Mosmann et al. 1989 Mosmann TR, Coffmann RL: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989; 7:145-173

Mueller et al. 1989 Mueller DL, Jenkins MK, Schwarz RH: Clonal expansion versus clonal inactivation a costimulatory signaling pathway determines the outcome of T cell antigen receptor eccupancy. Ann Rev Immunol 1989; 7, 445

Petrasch et al. 1990 Petrasch S, Perez-Alvarez C, Schmitz J, Kosco M, Brittinger G.: Antigenic phenotyping of human follicular dendritic cells isolated from nonmalignant and malignant lymphatic tissue. Eur J Immunol 1990 May; 20(5):1013-8

Radin et al. 1991 Radin EL, Burr DB, Caterson B, Fyhrie D, Brown TD, Boyd RD: Mechanical determinants of osteoarthrosis. Semin Arthritis Rheum. 1991 Dec; 21 (3 Suppl 2):12-21

Remmele 1997 Remmele W: Pathologie. Springer 1997; Band 5: 444-454

Reparon-Schuijt et al. 2001 Reparon-Schuijt CC, van Esch WJ, van Kooten C, Ezendam NP, Levarht EW, Breedveld FC, Verweij CL.: Presence of a population of CD20+, CD38- B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritis. Arthritis Rheum 2001 Sep; 44(9): 2029-37

Revell et al. 1988 Revell PA, Mayston V, Lalor P, Mapp P: The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis 1988 Apr; 47(4):300-7

Rhaney & Lamb 1955 Rhaney K, Lamb DW: The cysts of osteoarthritis of the hip. J. Bone Joint Surg 1955; 37: 511-515

Ristow et al. 1999 Ristow G, Krenn V, Souto Carneiro MM, König A, Kramer C, Müller-Hermelink HK: Immunophenotype of the inflammatory infiltrate and expression of interleukin 2 and interleukin 10 in osteoarthrotic synovial tissue. Pathol. Res Pract 1999; 195:317

Sakkas et al. 1998 Sakkas LI et al.: Interleukin 2 (IL-2) transcripts were found in 10 of 18 patients, Gamma interferon (IFN-gamma) transcripts were detected in 9 of 18 patients with OA, whereas IL-10 transcripts were found in nearly all patients Clin Diagn Lab Immunol 1998 Jul ;5(4):430-7

Seder et al. 1994 Seder RA and Paul WE: Acquisition of lymphokine-producing phenotype by CD 4+ T cells. Annu. Rev. Immunol. 1994, 12 635-673

Shaun et al. 2000 Shaun R, Edward DH, Clement BS: Kelley's Textbook of Rheumatology. W.B. Saunders Company 2000

Soren et al. 1988 Soren A, Cooper NS, Waugh TR: The nature and designation of osteoarthritis determined by ist histopathology. Clin Exp Rheumatol 1988; 6: 41-46

Souto-Carneiro et al. 1999 Souto-Carneiro MM, Krenn V, Hermann R, Ristow G, Konig A, Muller-Hermelink HK: Mutational pattern of Ig-VH genes of synovial B-lymphocytes from different anatomical locations in a rheumatoid arthritis patient. Verh Dtsch Ges Pathol 1999; 83:260-9

Springer 1990Springer TA: Adhesion receptors of the immune system. Native Lond 1990 346, 425

Stiehl 1997Stiehl P (1997): Histologie der Rheumatoid-Arthritis. Beitrag zur diagnostischen und pathogenetischen Heterogenität, zur Aktivitätsdiagnose und Prognose. In U. Sack (Hrsg) Update: Clin Immunol 5:188-200

Sulzbacher 2000 Sulzbacher I: Arthrosis - histology and pathogenetic approaches . Radiologe 2000 ; 40 ( 12 ): 1126-33

Sun et al. 1997 Sun Y, Sturmer T, Gunther KP, Brenner H: Incidence and prevalence of cox- and gonarthrosis in the general population]. Z Orthop Ihre Grenzgeb 1997 May-Jun; 135(3):184-92

Trinchieri et al. 1996 Trinchieri G, Perrit D, Gerosa F: Acute induction and priming for cytokine production in lymphocytes Cytokine Growth Factor Rev. 1996 Aug; 7(2):123-32

van den Berg 1999 Van den Berg WB: The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis. Z Rheumatol 1999 Jun; 58(3):136-41

van den Berg 2001 Van den Berg WB: Lessons from animal models of osteoarthritis. Curr Opin Rheumatol 2001 Sep; 13(5):452-6

van Seventer et al. 1991 Van Seventer GA, Shimizu Y, Shaw S: Roles of multiple accessory molecules in T cell activation. Curr Opin Imminol 1991; 3, 294

Vieira et al. 1991 Vieira P, de Waal-Malefyt R, Dang MN, Johnson KE, Kastelein R, Fiorentino DF, deVries JE, Roncarolo MG, Mosmann TR, Moore KW: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A 1991 Feb 15; 88(4):1172-6

Vingård et al. 1991 Vingård E, Alfredsson L, Goldie I, Hogstedt C: Occupation and ostheoarthrosis of the hip and knee: A register-based cohort study. Int J Epidemiol 1991; 20:1025-1031.

Wedge et al. 1991 Wedge JH, Wasylenko MJ, Houston CS: Minor anatomic abnormalities of the hip joint persisting from childhood and their possible relationship to idiopathic osteoarthrosis. Clin Orthop 1991; 264: 122-128

Wong et al. 2001 Wong CK, Ho CY, Ko FW, Chan CH, Ho AS, Hui DS, Lam CW: Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and TH cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001 Aug; 125(2):177-83

Yamamoto et al. 1996 Yamamoto M, Vancott JL, Okahashi N, Marinaro M, Kiyono H, Fujihashi K, Jackson RJ, Chatfield SN, Bluethmann H, McGhee JR: The role of TH1 and TH2 cells for mucosal IgA response. Ann N Y Acad Sci 1996; 778: 64-71

Zimny 1988 Zimny ML : Mechanoreceptors in articular tissues Am J Anat 1998; 182:16-32.

Zwillich et al. 1994 Zwillich SH, Fang Q, Kieber-Emmons T, Vonfeldt J, Monos D, Ramanujam T, Wang B, Weiner DB Willams WV: V alpha gene usage in rheumatoid compared with osteoarthritic synovial tissue T cells. DNA Cell Biol 1994; 13:923-931

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 3.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am: