[Seite 79↓]

Literaturverzeichnis

Adams, J. M., Cory S. (1998) . The Bcl-2 protein familiy: arbiters of cell survival. Science 281, 1322-26.

Adams, P. D., Kaelin W. G. Jr. (1996) . The cellular effects of E2F overexpression . Curr Top Microbiol Immunol 208, 79-93

Altman, D. G., Lausen, B., Sauerbrei, W. et al. (1994) . Dangers of using "optimal" cutpoints in the evaluation of prognostic factors . J Natl Cancer Inst 86, 829-35.

Andre, T., Boni, C., Mounedji-Boudiaf, L. et al.(2004). Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350, 23, 2343-51.

Arbeitsgemeinschaft Bevölkerungsbezogener Krebsregister in Deutschland (2002). Krebs in Deutschland - Häufigkeiten und Trends . 3. erweiterte, aktualisierte Ausgabe. Saarbrücken: Arbeitsgemeinschaft Bevölkerungsbezogener Krebsregister in Deutschland, 28-32.

Arbeitsgemeinschaft CAO/AIO/ARO der Deutschen Krebsgesellschaft ( 1999 ). Aktualisierter Konsensus der CAO/AIO/ARO zur adjuvanten Therapie bei Kolon- und Rektumkarzinom . Onkologie, 22 , 154-56 .

Bargou R. C., Wagener C., Bommert K. et al. (1996). Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest 97, 2651-59.

Boland, D., Thibodeau, S., Hamilton, S. et al.(1998). A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58: 5248-57.

Borresen-Dale, A. L., Lothe, R. A., Meling, G. I. et al. (1998) . TP53 and long-term prognosis in colorectal cancer: Mutations in the L3 zinc-binding domain predict poor survival. Clin Cancer Res 4, 203-210.

Bos, J. L. (1989). ras oncogenes in human cancer: a review . Cancer Res 49, 4682-89.


[Seite 80↓]

Bosanquet A. G., Sturm I., Wieder T. et al. (2002) . Bax expression correlates with cellu lar drug sensitivity to doxorubicin, cyclophosphamid and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. Leukemia 16, 1035-44.

Bosari, S., Viale, G. (1995) . The clinical significance of p53 aberrations in human tumors. Virchows Arch 427, 229-41.

Bosari, S., Viale, G., Bossi, P. (1994). Cytoplasmic accumulation of p53 Protein: an independent prognostic indicator in colorectal adenocarcinomas. J Natl Cancer Inst 86, 681-87.

Carton, P. F., Oliver, L., Martin, S. et al. (2002). The expression of a new variant of pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients . Hum Mol Genet 11, 6, 675-87.

Chang C., Simmsons D. T., Martin M. A. et al. (1979) . Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells. J Virol 31, 463-71.

Cohen, A. M., Minsky, M. B., Schilsky, R. L. (1997) . Cancer of the Colon . In: Cancer. Principles and Practice of Oncology. DeVita, V. T. Jr., Hellmann, S, Rosenberg, S. A. Philadelphia : Lippincott-Raven, 1144-1186.

Condie, A. (1993) . Detection of point mutations in the p53 gene: comparison of SSCP, constant denaturating gel electrophoresis and hydroxylamine and osmium tetroxide techniques. Hum Mutat 2, 58-66.

Cory, S., Vaux, D. L., Strasser, A. et al. (1999) . Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res 59, 1685-92.

Crompton, M. (2000) . Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis. Curr Opin Cell Biol 12, 414-19.

Daniel, P. T. (2000) . Dissecting the pathways to death. Leukemia 14, 2035-44.

Daniel, P. T. (2003a ). Zellzyklus und Apoptose. In: Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Ganten, Ruckpaul. Heidelberg : Springer-Verlag, 130-174.


[Seite 81↓]

Daniel, P. T., Kroidl, A., Kopp, J., et al. (1998) . Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "veto" apoptosis of antibody-targeted cytotoxic T cells . Blood 92, 4750-7.

Daniel, P. T., Schulze-Osthoff, K., Belka, C. et al. (2003b ). Guardians of cell death: the Bcl-2 family proteins . Essays Biochem , 39 , 73-88.

Daniel, P. T., Wieder, T., Sturm, I. et al. (2001) . The kiss of death: Promises and failures of death receptors and ligands in cancer therapy. Leukemia 15, 1022-32.

DeAngelis, P. M., Stokke, T., Thorstensen, L. et al (1998). Apoptosis and expressionof Bax, Bcl-x, and Bcl-2apoptotic regulatory proteins in colorectal carcinomas, and associations with p53 geontype/phenotype. J Clin Pathol: MolPathol 51 , 254-61.

Elsaleh, H., Powell, B., Soontrapornchai, P. et al. (2000) . p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 338 patientswith Dukes´ C colon carcinoma. Oncology 58, 52-9.

Eskes, R., Desagher, S., Antonsson, B. et al. (2000 ): Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane . Mol Cell Biol 20 , 929-35.

Evan, G. I., Vousden, K. H. (2001) . Proliferation, cell cycle and apoptosis in cancer. Nature 441, 342-48.

Evan, G. I., Wyllie, A. H. Gilbert, C. S. et al. (1992) . Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-28.

Fearon, E. R., Vogelstein, B. (1990) . A genetic model for colorectal tumorigenesis. Cell 61, 759-67.

Fizzotti, M., Cimino, G., Pisegna, S. et al. (1995) . Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood 85, 2685-90.

Foster, B. A., Coffey, H. A., Morin, M. J. et al. (1999) . Pharmacological rescue of mutant p53 conformation and function. Science 286, 2507-10.

Frank, S., Gaume, B., Bergmann-Leitner, E. S. et al. (2001). The role of dynamin-related protein I, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1, 515-25.


[Seite 82↓]

Friedrich K., Wieder T., Haefen C von et al. (2001) . Overexpression of caspase-3 re stores sensitivity for drug-induced apoptosis in breast cancer cell lines with aquired drug resistance. Oncogene 20, 2749-60.

Friess, H., Lu, Z., Graber, H. U. et al. (1998) . Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut 43, 414-421.

Funk, F. O. (1999) . Cancer cell cycle control. Anticancer Res 19, 4772-80.

Gascoyne, R. D., Krajewska, M., Krajewsky, S. et al. (1997) . Prognostic significance of BAX protein expression in diffuse aggressive Non-Hodgkin´s lymphoma. Blood 90, 3173-3178.

Geradts, J., Kratzke, R. A., Niehans, G. A. et al. (1995) . Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. Cancer Res 55, 6006-11.

Gillet, C. E., Barnes, D. M. (1998) . Demystified... Mol Pathol 51, 310-16.

Gillissen, B., Essmann, F., Graupner, V. et al . (2003) . Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J 22, 14, 3580-90.

Glantz S. A. (1998) . Wie man Überlebenszeiten analysiert . In: Biotstatistik: Ein Fach für die Praxis. Hrsg. der dt. Ausg.: Achim Heinecke, Wolfgang Köpcke . McGraw-Hill: Frankfurt/M 150-75.

Goh, H. S., Yao, J., Smith, D. R. (1995) . p53 point mutation and survival in colorectal cancer patients. Cancer Res 55, 5217-21.

Goldstein, A. M., Fraser, M. C., Struewing, J. P. (1995) . Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4a mutations. N Engl J Med 333, 970-74.

Grabowski, P., Mann, B., Mansmann, U. et al. (2000) . Expression of SIALYL-Le(x) antigen defined by MAb AM-3 is an independent prognostic marker in colorectal carcinoma patients. Int J Cancer 88, 281-6.

Grabowski, P.,Schindler, I., Anagnostopoulos, I. et al. (2001) . Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer. Eur Jour Gastroent Hepatol 13, 405-11.


[Seite 83↓]

Grana, X.,Garriga, J., Mayol, X. (1998) . Role of the retinoblastoma protein family, pRB, p107, and p130 in the negative control of cell growth. Oncogene 17, 3365-83.

Greene, F. L. (2003). A new TNM-staging strategy for node-positive (stage III) rectal cancer: An analysis of 5.988 patients . ASCO Annunal Meeting. Gastrointestinal Cancer. Colorectal Cancer Malignancies . www.asco.org .

Gronbaek, K., Nully Brown, P de, Moller, M. B. et al. (2000) . Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin´s lymphoma. Leukemia 14, 1727-35.

Gross, A., McDonnell, J. M., and Korsmeyer, S. J. (1999) . BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13, 1899-911.

Güner, D., Sturm, I., Hemmati, P. G. et al. (2003) . Multigene analysis of Rb-pathway and apoptosis-control in esophageal squamous cell carcinoma identifies patients with good prognosis. Int J Cancer 103, 445-54.

Hamelin, R., Laurent, P. P., Olschwang, S. et al. (1994) . Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 106, 42-8.

Hasegawa, H., Ueda, M., Furukawa, K. et al. (1995) . p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. Int J Cancer 64, 47-51.

Hayashi, K., Yandell, D. W. (1998) . How sensitive is PCR-SSCP? Hum Mutat 2, 338-46.

Hemmati, P. G., Gillissen, B., von Haefen, C. et al. (2002) . Adenovirus-mediated overexpression of p14ARF induces p53 and bax-independent apoptosis. Oncogene 21, 3149-61.

Hermanek, P. (1997) . Prognostische Faktoren beim kolorektalen Karzinom. Zentralbl Chir 122, 20-25.

Hermanek, P., Mansmann, U., Staimmer, D. S. et al. (2000) . The German experience. the surgeon as a prognostic factor in colon and rectal cancer surgery . Surg Oncol Clin N Am 9, 33-49.

Hermanek, P., Wiebelt, H., Staimmer, D. (1995 ). Expierience of the German multicenter study group SGCRC. Tumori Suppl 81 , 60-4 .


[Seite 84↓]

Hermann, S., Sturm, I., Mrozek, A. et al. (2001) . BAX expression in benign and malig nant thyroid tumors: Dysregulation of wild type p53 is associated with a high BAX and p21 expression in thyroid carcinoma. Int J Cancer 92, 8 , 805-11 .

Heyman, M., Rasool, O., Borgonovo Brandter, L. et al. (1996) . Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. J Clin Oncol 14, 1512-20.

Hollstein, M., Rice, K., Greenblatt, M. S. et al. (1994) . Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res 22, 3551-5.

Houlston, R. S., Collins, A., Slack, J et al. (1992). Dominant genes for colorectal cancer are not rare. Ann Hum Genet 56, 99-103.

Hsu, Y. T., Youle, R. J. (1998). Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem 273, 10777-83.

Hu, Y. X., Watanabe, H., Ohtsubo, K. et al. (1997) . Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res 3, 1473-77.

Huang, C. I., Taki, T., Higashiyama, M. et al. (2000). p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung. Br J Cancer 82, 374-80.

Hussussian, C. J., Struewing, J. P., Goldstein, A. M. (1994) . Germline p16 mutations in familial melanoma. Nat Genet 8, 15-21.

Inohara, N., Ding, L., Chen, S. et al. (1997) . Harakiri, a novel regualator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 16, 1686-94.

Johnson, D. G., Walker, C. L. (1999) . Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 39, 295-312.

Jürgensmeier, J. M., Xie, Z. H., Deveraux, Q. et al. (1998) . Bax directly induces release of cytochrome c from isolated mitochondria. Proc Nat Acad Sci USA 95, 4997-5002.


[Seite 85↓]

Kannan, K., Kaminski, N., Rechavi, G. et al. (2001) . DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of APAF-1. Oncogene 20, 3449- 55.

Kinzler, K. W., Nilbert, M. C., Vogelstein, B. et al. (1991) . Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 253, 661-665.

Kinzler, K. W., Vogelstein, B. ( 1996 ). Lessons from hereditary colorectal cancer . Cell 87 , 159-70 .

Klasa, R. F., List, A. F., Cheson, B. D. (2001) . Rational approches to design of therapeutics targeting molecular markers. Hematology (Am Soc Hematol Educ Program), 443-62.

Krajewski, S., Blomqvist, C., Franssila, K. et al. (1995) . Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55, 4471-8.

Krammer, P. H. (2000) . CD95´s deadly mission in the immune system. Nature 407, 789-95.

Kratzke, R. A., Greatens, T. M., Rubins, J. B. et al. (1996) . Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res 56, 3415-20.

Kress, M., May, E., Cassingena, R. et al. (1979) . Simian virus 40-transformed cells express new species of proteins precitable by simian virus 40 serum. J virol 31, 472-83.

Kroemer, G. J., Reed, C. (2000) . Mitochondrial control of cell death . Nat Med 6, 523-19.

Laken, S. J., Petersen, G. M., Gruber, S. B. et al.(1997). Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nature Genet 17, 79-83.

Lane, D. P., Crawford, L. V. (1979). T antigen is bound to a host protein in SV40-transformed cells. Nature 278, 261-263.

Lauber, K., Bohn, E., Kröber, S. M. et al. (2003). Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of lipid attraction signal. Cell 113, 717-30.

Li, A. J., Blow, J. (2001) . The origin of CDK regulation. Nat Cell Biol 3, E182-84.


[Seite 86↓]

Li, P., Nijhawan, D., Budihardjo, I. et al. (1997) . Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-89.

Liang, J., Chang, K., Chen, J. et al. (1999) . Hypermethylation of the p16 gene in sporadic T3 N0 M0 stage colorectal cancer: association with DNA replication error and shorter survival. Oncology 57, 149-56.

Linzer, D. I. H., Levine, A. J. (1979) . Characterization of a 54 KDa cellular tumorantigen present in SV40-transformed cells and in infected embryonal carcinoma cells. Cell 1, 43-52.

Lorenz, M., Mueller, H. H., Mattes, E. et al. ( 2001 ). Phase II study of weekly 24-hour intra-arterial high-dose infusion of 5-fluorouracil and folinic acid for liver metastases from colorectal cancer. Ann Oncol 12 , 3 , 321-5.

Lorenz, M., Staib-Sebler, E., Gog, C. et al. (2003). Prospective pilot study of neoadjuvant chemotherapy with 5-fluorouracil, folinic acid and oxaliplatin in resectable liver metastases of colorectal cancer. Analysis of 42 neoadjuvant chemotherapies. Zentralbl Chir 128, 2, 87-94.

Lowry, D. R., Willumsen, B. M. (1993). Function and regulation of ras . Ann Rev Biochem 62, 851-91.

Luo, X., Budihardjo, I., Zou, H. et al. (1998) . Bid, a Bcl-2 interacting protein, mediates cytochrom c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-90.

Maaser, K., Hopfner, M., Jansen, A. et al. (2001) . Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer 85, 1771-80.

Marks, J. R., Davidoff, A. M., Kerns, B. J. et al.(1991). Overexpression and mutations in epithelial ovarian cancer. Cancer Res 51, 2979-84.

Martinou, J. C., Green, D. R. (2001) . Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2, 63-67.

Müller-Tidow, C., Metzelder, S. K., Buerger, H. (2004). Expression of the p14(ARF) tumor suppressor predicts survival in acute myeloid leukemia. Leukemia. Epub ahead of print.


[Seite 87↓]

McCurrach, M. E., Connor, T. M., Knudson, C. M. (1997) . Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci U S A 94, 2345-9.

Meijerink, J. P., Mensink, E. J., Wang, K. et al. (1998) . Hematopoetic malignancies demonstrate loss-of-function mutations of BAX. Blood 91, 8 , 2991-7.

Merkel, S., Mansmann, U., Papadopoulos, T. et al. (2001). The prognostic inhomogenity of colorectal carcinomas stage III. a proposal for subdivison of stage III. Cancer 92, 11, 2754-59.

Miller, B. A., Gloeckler, L. A., Hankaiy, W. F. et al. (1992 ). Cancer statistics review 1973-89. US Department of Health and Human Services , Bethesda.

Miyashita, T., Reed, J. C. (1995) . Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-9.

Miyoshi, Y., Iwao, K., Nagasawa, Y. (1998). Activation of the β -Catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 58 , 2524-27 .

Moertel, C. G., Fleming, T. R., Macdonald, J. S. et al. ( 1995 ). Fluorouracil plus levamisol as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 122, 5 , 321-6 .

Morin, P. J. (1999). β -Catenin signalling in cancer. BioEssays 21, 1021-30.

Morin, P. J., Vogelstein, B., Kinzler, K. W. (1996 ). Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci USA 93: 7950-54.

Nakano, K., Wousden, K. H. (2001) . PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7, 683-94.

Newton, C. R., Graham, A. (1994) . PCR . Heidelberg: Spektrum Akademischer Verlag, 156-58.

Oda, E., Ohki, R., Murasawa, H. et al. (2000) . Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053-58.

Ogura, E., Senzaki, H., Yamamoto, D. et al. (1999). Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. Oncol Reports 6, 365-69.


[Seite 88↓]

Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. (1993) . Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-19.

Orita, M. (1989) . Rapid and sensitive detection of point mutations and DNA polymorphisms using the PCR. Genomics 5, 874-79.

Ozawa, M., Baribault, H., Kemler, R. (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 8, 1711-17.

Papadimitrakopoulou, V., Izzo, J., Lippman, S. M. et al. (1997) . Frequent inactivation of p16INK4a in oral premalignant lesions. Oncogene 14, 1799-803.

Paradiso, A., Rabinovich, M., Vallejo, C. et al. (1996) . p53 and PCNA expression in advanced colorectal cancer: response to chemotherapy and long-term prognosis. Int J Cancer 69, 437-41.

Pastorino, J. G., Chen, S. T., Tafani, M. et al. (1998) . The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 273, 7770-7775.

Poller, D. N., Baxter, K. J., and Shepherd, N. A. (1997) . p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? Br J Cancer 75, 87-93.

Pricolo, V. E., Finkelstein, S. D., Hansen, K. et al. (1997) . Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch Surg 132, 371-4.

Prokop, A., Wieder, T., Sturm, I. et al. (2000) . Relapse of childhood acute lymphoblastic leukemia is associtated with a decrease of the bax/bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia 14, 1606-13.

Radetzki, S., Kohne, C. H., von Haefen, C. et al. (2002) . The apoptosis promoting bcl-2 homologs nbk/bik overcome drug resistance in mdr-1-negative and mdr-1-overexpressing breast cancer cell lines. Oncogene 20, 227-38.

Rampino, N., Yamamoto, H., Ionov, Y. et al. (1997). Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275, 967-9.


[Seite 89↓]

Rao, R. V., Hermel, E., Castro-Obregon, S. et al. (2001) . Coupling endoplasmic reticu lum stress to the cell death program. Mechanism of caspase activation . J Biol Chem 276, 33869-74.

Rau, B., Sturm, I., Lage, H. et al. (2003) . Dynamic Expression Profile of 21WAF/CIP1 and Ki-67 predicts survival in rectal carcinoma treted with preoperative radiochemotherapy. J Clin Oncol 21, 3391-3401.

Reed, J. A., Loganzo, F., Jr., Shea, C. R. et al. (1995) . Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res 55, 2713-8.

Reed, J. C., Miyashita, T., Takayama, S. et al. (1996) . Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60, 23-32.

Robbins, P. F., El-Gamil, M., Li, Y. F. (1996). A mutated β -catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes . J Exp Med 183 , 1185-92.

Rodrigues, N. R., Rowan, A., Smith, M. E. et al. (1990). p53 mutations in colorectal cancer. Proc Natl Acad Sci USA 87, 7555-59.

Roussel, M. F. (1999) . The INK4a family of cell cycle inhibitors in cancer. Oncogene 18, 5311-17.

Rozenfeld-Granot, G., Toren, A., Amariglio, N. et al. (2001) . Mutation analysis of the FAS and TNFR apoptotic cascade genes in hematological malignancies. Exp Hematol 29, 399-402.

Ruas, M., Peters, G. (1998) . The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1378, F115-77.

Rudner, J., Jendrossek, V., Belka, C. (2002). New insights in the role of Bcl-2 Bcl-2 and the endoplasmatic reticulum. Apoptosis, 7, 5, 441-7.

Sandig, V., Brand, K., Herwig, S. et al. (1997) . Adenovirally transferred p16INK4/ CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med 3, 313-9.


[Seite 90↓]

Schmitt, C, A., McCurrach, M. E., Stanchina, E. de et al. (1999) . INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by diabling p53. Genes Dev 13, 2670-2677.

Schmoll, H. J. (1997). Kolorektales Karzinom. In: Kompendium Internistische Onkologie. Schmoll, H. J., Höffken, K., Possinger, K. Heidelberg: Springer Verlag, 694-759.

Senderowicz, A. M. (2000) . Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene 19, 6600-6606.

Serrano, M., Lin, A. W., McCurrach, M. E. et al. (1997) . Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.

Shapiro, G. I., Edwards, C. D., Ewen, M. E. et al. (1998) . p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18, 378-87.

Sharpless, N. E., DePinho, R. A. (1999) . The INK4a/ARF locus and its two gene products. Curr Opin Genet Dev 9, 22-30.

Shimizu, S., Ide, T., Yanagida, T. et al. (2000) . Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem 275, 12321-25 .

Simms, L. A., Radford-Smith, G., Biden, K. G. et al. (1998). Reciprocal Relationship between the tumor suppressors p53 and BAX in primary colorectal cancer. Oncogene, 17 , 15 , 2003-8.

Soengas, M. S., Capodieci, P., Polsky, D. et al. (2001). Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409, 207-11.

Soong, R., Powell, B., Elsaleh, H. et al. (2000) . Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma. Influence of tumor site, stage, adjuvant chemotherapy and type of mutation. Eur J Cancer 36, 2055-60.

Soong, R., Robbins, P. D., Dix, B. R. et al. (1996) . Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 27, 1050-5.

Sturm, I., Bosanquet, A., Head, D. (2003) . P53 mutation in B-CLL: Impact on drug sensitivity profiles and disease prognosis. Cell Death Diff 10, 477-84.


[Seite 91↓]

Sturm, I., Kohne, C. H., Wolff, G. et al. (1999) . Analysis of the p53/BAX pathway in colo rectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 17, 1364-74.

Sturm, I., Papadopoulos, S., Hillebrand, T. et al. (2000) . Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene. Int J Cancer 87, 517-21.

Sturm, I., Petrowsky, H., Volz, R. et al. (2001) . Analysis of p53/BAX/p16INK4a/CDKN2 in esophageal squamous cell carcinoma: High BAX and p16INK4a/CDKN2 identifies patients with good prognosis. J Clin Oncol, 19, 8, 2272-81.

Sugarbaker, J. P., Gunderson, L. L., Wittes, R. E. (1985). Colorectal cancer . Cancer: Principles and practices of oncology. DeVita, V. T., Hellmann, S., Rosenberg, S. A. Philadelphia: J. B. Lippincott 800-3.

Tai, Y. T., Lee, S., Niloff, E. et al. (1998) . BAX protein expression and clinical outcome in epithelial ovarian cancer. J Clin Oncol 16, 2583-90.

Taylor, W. R., Stark, G. R. (2001) . Regulation of the G2/M transition by p53. Oncogene 20, 1803-15.

Tournigand, C., Andre, T., Achille, E. et al.(2004). FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22, 2, 229-37.

van Loo, G., Saelens, X., van Gurp, M. et al. (2002). The role of mitochondrial factors in apoptosis: a russian roulette with more than one bullet . Cell Death Diff 9, 1031-42.

Violette, S., Poulain, L., Dussaulx, E. et al. (2002) . Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the realtive level of Bcl-2 and Bcl-X(L) in addition to the Bax and p53 status . Int J Cancer 98, 4 , 498-504.

Vogelstein, B., Fearon, E. R., Hamilton, S. R. (1988). Genetic alterations during colorectal-tumor development. N Engl J Med 319, 9, 527-32.

Wagener, C., Bargou, R. C., Daniel, P. T. et al. (1996) . Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer 67, 138-41.


[Seite 92↓]

Waldman, T., Lengauer, C., Kinzler, K. W. et al. (1996) . Uncoupling of S phase and S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-16.

Wang, K., Yin, X. M., Chao, D. T. et al. (1996) . Bid: a novel BH3 domain-only death agonist. Genes Dev 10, 2859-69.

Weissburger, J. H., Wynder, E. L. (1987). Etiology of colorectal cancer with emphasis on mechanism of action and prevention. Important advances in oncology. DeVita, V. T., Hellmann, S., Rosenberg, S. A. Philadelphia: J. B. Lippincott, 197.

Weyrer, K., Feichtinger, H., Haun, M. et al. (1996) . p53, Ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas. Lab Invest 74, 279-89.

Wieder, T., Essmann, F., Prokop, A. et al. (2001) . Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3 . Blood 97, 5 , 1378-87.

Wu, G. S., El-Deiry, W. S. (1996) . Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2. Clin Cancer Res 2, 623-33.

Xiong, Y., Hannon, G. J., Zhang, H. et al. (1993) . p21 is a universal inhibitor of cyclin dependent kinases. Nature 366, 6456 , 701-4.

Yang, J., Liu, X., Bhalla, K. (1997) . Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-32 .

Zeng, Z. S., Sarkis, A. S., Zhang, Z. F. et al. (1994). p53 nuclear overexpression: an independent predictor of survival in lymphnode positive colorectal cancer patients. J Clin Oncol 12, 10, 2043-50.


© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 3.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am:
26.01.2005