Referenzen

[1] Springer, T. A. (1994): Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm, Cell 76 [2], pp.301-14. PM=7507411

[2] Schaerli, P. and Moser, B. (2005): Chemokines: control of primary and memory T-cell traffic, Immunol Res 31 [1], pp.57-74. PM=15591623

[3] Salmi, M. and Jalkanen, S. (1997): How do lymphocytes know where to go: current concepts and enigmas of lymphocyte homing, Adv Immunol 64, pp.139-218. PM=9100982

[4] Butcher, E. C.; Williams, M.; Youngman, K.; Rott, L. and Briskin, M. (1999): Lymphocyte trafficking and regional immunity, Adv Immunol 72, pp.209-53. PM=10361577

[5] Patel, K. D.; Cuvelier, S. L. and Wiehler, S. (2002): Selectins: critical mediators of leukocyte recruitment, Semin Immunol 14 [2], pp.73-81. PM=11978079

[6] van der Flier, A. and Sonnenberg, A. (2001): Function and interactions of integrins, Cell Tissue Res 305 [3], pp.285-98. PM=11572082

[7] Johnston, B. and Butcher, E. C. (2002): Chemokines in rapid leukocyte adhesion triggering and migration, Semin Immunol 14 [2], pp.83-92. PM=11978080

[8] Chensue, S. W. (2001): Molecular machinations: chemokine signals in host-pathogen interactions, Clin Microbiol Rev 14 [4], pp.821-35, table of contents. PM=11585787

[9] Kim, C. H. (2004): Chemokine-chemokine receptor network in immune cell trafficking, Curr Drug Targets Immune Endocr Metabol Disord 4 [4], pp.343-61. PM=15578986

[10] Moser, B.; Wolf, M.; Walz, A. and Loetscher, P. (2004): Chemokines: multiple levels of leukocyte migration control, Trends Immunol 25 [2], pp.75-84. PM=15102366

[11] Thelen, M. (2001): Dancing to the tune of chemokines, Nat Immunol 2 [2], pp.129-34. PM=11175805

[12] Loetscher, P.; Moser, B. and Baggiolini, M. (2000): Chemokines and their receptors in lymphocyte traffic and HIV infection, Adv Immunol 74, pp.127-80. PM=10605606

[13] Rot, A. (1992): Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration, Immunol Today 13 [8], pp.291-4. PM=1510812

[14] Clark-Lewis, I.; Kim, K. S.; Rajarathnam, K.; Gong, J. H.; Dewald, B.; Moser, B.; Baggiolini, M. and Sykes, B. D. (1995): Structure-activity relationships of chemokines, J Leukoc Biol 57 [5], pp.703-11. PM=7759949

[15] Lortat-Jacob, H.; Grosdidier, A. and Imberty, A. (2002): Structural diversity of heparan sulfate binding domains in chemokines, Proc Natl Acad Sci U S A 99 [3], pp.1229-34. PM=11830659

[16] Tumova, S.; Woods, A. and Couchman, J. R. (2000): Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions, Int J Biochem Cell Biol 32 [3], pp.269-88. PM=10716625

[17] Johnson, Z.; Proudfoot, A. E. and Handel, T. M. (2005): Interaction of chemokines and glycosaminoglycans: A new twist in the regulation of chemokine function with opportunities for therapeutic intervention, Cytokine Growth Factor Rev. PM=15990353

[18] Witt, D. P. and Lander, A. D. (1994): Differential binding of chemokines to glycosaminoglycan subpopulations, Curr Biol 4 [5], pp.394-400. PM=7922353

[19] Kuschert, G. S.; Coulin, F.; Power, C. A.; Proudfoot, A. E.; Hubbard, R. E.; Hoogewerf, A. J. and Wells, T. N. (1999): Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses, Biochemistry 38 [39], pp.12959-68. PM=10504268

[20] Middleton, J.; Neil, S.; Wintle, J.; Clark-Lewis, I.; Moore, H.; Lam, C.; Auer, M.; Hub, E. and Rot, A. (1997): Transcytosis and surface presentation of IL-8 by venular endothelial cells, Cell 91 [3], pp.385-95. PM=9363947

[21] Patel, D. D.; Koopmann, W.; Imai, T.; Whichard, L. P.; Yoshie, O. and Krangel, M. S. (2001): Chemokines have diverse abilities to form solid phase gradients, Clin Immunol 99 [1], pp.43-52. PM=11286540

[22] Webb, L. M.; Ehrengruber, M. U.; Clark-Lewis, I.; Baggiolini, M. and Rot, A. (1993): Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8, Proc Natl Acad Sci U S A 90 [15], pp.7158-62. PM=8346230

[23] Middleton, J.; Patterson, A. M.; Gardner, L.; Schmutz, C. and Ashton, B. A. (2002): Leukocyte extravasation: chemokine transport and presentation by the endothelium, Blood 100 [12], pp.3853-60. PM=12433694

[24] Baekkevold, E. S.; Yamanaka, T.; Palframan, R. T.; Carlsen, H. S.; Reinholt, F. P.; von Andrian, U. H.; Brandtzaeg, P. and Haraldsen, G. (2001): The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment, J Exp Med 193 [9], pp.1105-12. PM=11342595

[25] Stein, J. V.; Rot, A.; Luo, Y.; Narasimhaswamy, M.; Nakano, H.; Gunn, M. D.; Matsuzawa, A.; Quackenbush, E. J.; Dorf, M. E. and von Andrian, U. H. (2000): The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules, J Exp Med 191 [1], pp.61-76. PM=10620605

[26] Palframan, R. T.; Jung, S.; Cheng, G.; Weninger, W.; Luo, Y.; Dorf, M.; Littman, D. R.; Rollins, B. J.; Zweerink, H.; Rot, A. and von Andrian, U. H. (2001): Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues, J Exp Med 194 [9], pp.1361-73. PM=11696600

[27] Friedl, P. and Storim, J. (2004): Diversity in immune-cell interactions: states and functions of the immunological synapse, Trends Cell Biol 14 [10], pp.557-67. PM=15450978

[28] Chambers, C. A. and Allison, J. P. (1999): Costimulatory regulation of T cell function, Curr Opin Cell Biol 11 [2], pp.203-10. PM=10209159

[29] Hutloff, A.; Dittrich, A. M.; Beier, K. C.; Eljaschewitsch, B.; Kraft, R.; Anagnostopoulos, I. and Kroczek, R. A. (1999): ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28, Nature 397 [6716], pp.263-6. PM=9930702

[30] Swallow, M. M.; Wallin, J. J. and Sha, W. C. (1999): B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha, Immunity 11 [4], pp.423-32. PM=10549624

[31] Yamazaki, T.; Akiba, H.; Koyanagi, A.; Azuma, M.; Yagita, H. and Okumura, K. (2005): Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-{gamma}-Induced Nitric Oxide Production, J Immunol 175 [3], pp.1586-92. PM=16034097

[32] Sancho, D.; Yanez-Mo, M.; Tejedor, R. and Sanchez-Madrid, F. (1999): Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15, Blood 93 [3], pp.886-96. PM=9920837

[33] Van Seventer, G. A.; Shimizu, Y.; Horgan, K. J. and Shaw, S. (1990): The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells, J Immunol 144 [12], pp.4579-86. PM=1972160

[34] Damle, N. K.; Klussman, K. and Aruffo, A. (1992): Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells, J Immunol 148 [3], pp.665-71. PM=1346150

[35] Cayabyab, M.; Phillips, J. H. and Lanier, L. L. (1994): CD40 preferentially costimulates activation of CD4+ T lymphocytes, J Immunol 152 [4], pp.1523-31. PM=7509825

[36] Damle, N. K. and Aruffo, A. (1991): Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes, Proc Natl Acad Sci U S A 88 [15], pp.6403-7. PM=1713678

[37] Liu, Y.; Jones, B.; Aruffo, A.; Sullivan, K. M.; Linsley, P. S. and Janeway, C. A., Jr. (1992): Heat-stable antigen is a costimulatory molecule for CD4 T cell growth, J Exp Med 175 [2], pp.437-45. PM=1346270

[38] Hintzen, R. Q.; Lens, S. M.; Lammers, K.; Kuiper, H.; Beckmann, M. P. and van Lier, R. A. (1995): Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation, J Immunol 154 [6], pp.2612-23. PM=7876536

[39] Gramaglia, I.; Weinberg, A. D.; Lemon, M. and Croft, M. (1998): Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses, J Immunol 161 [12], pp.6510-7. PM=9862675

[40] Constant, S.; Pfeiffer, C.; Woodard, A.; Pasqualini, T. and Bottomly, K. (1995): Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells, J Exp Med 182 [5], pp.1591-6. PM=7595230

[41] Banchereau, J. and Steinman, R. M. (1998): Dendritic cells and the control of immunity, Nature 392 [6673], pp.245-52. PM=9521319

[42] Campbell, D. J.; Debes, G. F.; Johnston, B.; Wilson, E. and Butcher, E. C. (2003): Targeting T cell responses by selective chemokine receptor expression, Semin Immunol 15 [5], pp.277-86. PM=15001177

[43] Grossman, Z.; Min, B.; Meier-Schellersheim, M. and Paul, W. E. (2004): Concomitant regulation of T-cell activation and homeostasis, Nat Rev Immunol 4 [5], pp.387-95. PM=15122204

[44] Sallusto, F.; Lenig, D.; Forster, R.; Lipp, M. and Lanzavecchia, A. (1999): Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature 401 [6754], pp.708-12. PM=10537110

[45] Kaech, S. M.; Wherry, E. J. and Ahmed, R. (2002): Effector and memory T-cell differentiation: implications for vaccine development, Nat Rev Immunol 2 [4], pp.251-62. PM=12001996

[46] Kuwana, M. (2002): Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets, Hum Immunol 63 [12], pp.1156-63. PM=12480259

[47] Wallet, M. A.; Sen, P. and Tisch, R. (2005): Immunoregulation of dendritic cells, Clin Med Res 3 [3], pp.166-75. PM=16160071

[48] Gimmi, C. D.; Freeman, G. J.; Gribben, J. G.; Gray, G. and Nadler, L. M. (1993): Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation, Proc Natl Acad Sci U S A 90 [14], pp.6586-90. PM=7688125

[49] Schwartz, R. H. (1996): Models of T cell anergy: is there a common molecular mechanism?, J Exp Med 184 [1], pp.1-8. PM=8691122

[50] Marelli-Berg, F. M. and Jarmin, S. J. (2004): Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?, Immunol Lett 93 [2-3], pp.109-13. PM=15158605

[51] Weibel, E. R.; Staubli, W.; Gnagi, H. R. and Hess, F. A. (1969): Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver, J Cell Biol 42 [1], pp.68-91. PM=4891915

[52] Blouin, A.; Bolender, R. P. and Weibel, E. R. (1977): Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study, J Cell Biol 72 [2], pp.441-55. PM=833203

[53] Lau, A. H. and Thomson, A. W. (2003): Dendritic cells and immune regulation in the liver, Gut 52 [2], pp.307-14. PM=12524419

[54] Doherty, D. G. and O'Farrelly, C. (2000): Innate and adaptive lymphoid cells in the human liver, Immunol Rev 174, pp.5-20. PM=10807503

[55] Klugewitz, K.; Adams, D. H.; Emoto, M.; Eulenburg, K. and Hamann, A. (2004): The composition of intrahepatic lymphocytes: shaped by selective recruitment?, Trends Immunol 25 [11], pp.590-4. PM=15489187

[56] Smedsrod, B.; De Bleser, P. J.; Braet, F.; Lovisetti, P.; Vanderkerken, K.; Wisse, E. and Geerts, A. (1994): Cell biology of liver endothelial and Kupffer cells, Gut 35 [11], pp.1509-16. PM=7828963

[57] Wisse, E. (1970): An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids, J Ultrastruct Res 31 [1], pp.125-50. PM=5442603

[58] Seternes, T.; Sorensen, K. and Smedsrod, B. (2002): Scavenger endothelial cells of vertebrates: a nonperipheral leukocyte system for high-capacity elimination of waste macromolecules, Proc Natl Acad Sci U S A 99 [11], pp.7594-7. PM=12032328

[59] Lalor, T. and Adams, D. (2002): The liver: a model of organ-specific lymphocyte recruitment, Expert Rev Mol Med 2002, pp.1-15. PM=14987382

[60] Yamamoto, S.; Sato, Y.; Shimizu, T.; Halder, R. C.; Oya, H.; Bannai, M.; Suzuki, K.; Ishikawa, H.; Hatakeyama, K. and Abo, T. (1999): Consistent infiltration of thymus-derived T cells into the parenchymal space of the liver in normal mice, Hepatology 30 [3], pp.705-13. PM=10462377

[61] Klugewitz, K.; Blumenthal-Barby, F.; Eulenburg, K.; Emoto, M. and Hamann, A. (2004): The spectrum of lymphoid subsets preferentially recruited into the liver reflects that of resident populations, Immunol Lett 93 [2-3], pp.159-62. PM=15158612

[62] Wong, J.; Johnston, B.; Lee, S. S.; Bullard, D. C.; Smith, C. W.; Beaudet, A. L. and Kubes, P. (1997): A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature, J Clin Invest 99 [11], pp.2782-90. PM=9169509

[63] Scoazec, J. Y. and Feldmann, G. (1994): The cell adhesion molecules of hepatic sinusoidal endothelial cells, J Hepatol 20 [2], pp.296-300. PM=8006410

[64] Lalor, P. F.; Shields, P.; Grant, A. and Adams, D. H. (2002): Recruitment of lymphocytes to the human liver, Immunol Cell Biol 80 [1], pp.52-64. PM=11869363

[65] Liao, F.; Rabin, R. L.; Yannelli, J. R.; Koniaris, L. G.; Vanguri, P. and Farber, J. M. (1995): Human Mig chemokine: biochemical and functional characterization, J Exp Med 182 [5], pp.1301-14. PM=7595201

[66] Shields, P. L.; Morland, C. M.; Salmon, M.; Qin, S.; Hubscher, S. G. and Adams, D. H. (1999): Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver, J Immunol 163 [11], pp.6236-43. PM=10570316

[67] Khan, I. A.; MacLean, J. A.; Lee, F. S.; Casciotti, L.; DeHaan, E.; Schwartzman, J. D. and Luster, A. D. (2000): IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection, Immunity 12 [5], pp.483-94. PM=10843381

[68] Jiang, W.; Zhou, P.; Kahn, S. M.; Tomita, N.; Johnson, M. D. and Weinstein, I. B. (1994): Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA), Exp Cell Res 215 [2], pp.284-93. PM=7982471

[69] Sallusto, F.; Mackay, C. R. and Lanzavecchia, A. (2000): The role of chemokine receptors in primary, effector, and memory immune responses, Annu Rev Immunol 18, pp.593-620. PM=10837070

[70] Wald, O.; Pappo, O.; Safadi, R.; Dagan-Berger, M.; Beider, K.; Wald, H.; Franitza, S.; Weiss, I.; Avniel, S.; Boaz, P.; Hanna, J.; Zamir, G.; Eid, A.; Mandelboim, O.; Spengler, U.; Galun, E. and Peled, A. (2004): Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus, Eur J Immunol 34 [4], pp.1164-74. PM=15048728

[71] Hedrick, J. A. and Zlotnik, A. (1997): Identification and characterization of a novel beta chemokine containing six conserved cysteines, J Immunol 159 [4], pp.1589-93. PM=9257816

[72] Yoneyama, H.; Matsuno, K.; Zhang, Y.; Murai, M.; Itakura, M.; Ishikawa, S.; Hasegawa, G.; Naito, M.; Asakura, H. and Matsushima, K. (2001): Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease, J Exp Med 193 [1], pp.35-49. PM=11136819

[73] Grant, A. J.; Goddard, S.; Ahmed-Choudhury, J.; Reynolds, G.; Jackson, D. G.; Briskin, M.; Wu, L.; Hubscher, S. G. and Adams, D. H. (2002): Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease, Am J Pathol 160 [4], pp.1445-55. PM=11943728

[74] Matloubian, M.; David, A.; Engel, S.; Ryan, J. E. and Cyster, J. G. (2000): A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo, Nat Immunol 1 [4], pp.298-304. PM=11017100

[75] Heydtmann, M.; Lalor, P. F.; Eksteen, J. A.; Hubscher, S. G.; Briskin, M. and Adams, D. H. (2005): CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver, J Immunol 174 [2], pp.1055-62. PM=15634930

[76] Tanaka, Y.; Imai, T.; Baba, M.; Ishikawa, I.; Uehira, M.; Nomiyama, H. and Yoshie, O. (1999): Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans, Eur J Immunol 29 [2], pp.633-42. PM=10064080

[77] Schutyser, E.; Struyf, S. and Van Damme, J. (2003): The CC chemokine CCL20 and its receptor CCR6, Cytokine Growth Factor Rev 14 [5], pp.409-26. PM=12948524

[78] Dellacasagrande, J.; Schreurs, O. J.; Hofgaard, P. O.; Omholt, H.; Steinsvoll, S.; Schenck, K.; Bogen, B. and Dembic, Z. (2003): Liver metastasis of cancer facilitated by chemokine receptor CCR6, Scand J Immunol 57 [6], pp.534-44. PM=12791091

[79] Afford, S. C.; Fisher, N. C.; Neil, D. A.; Fear, J.; Brun, P.; Hubscher, S. G. and Adams, D. H. (1998): Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis, J Pathol 186 [1], pp.82-9. PM=9875144

[80] Pardigol, A.; Forssmann, U.; Zucht, H. D.; Loetscher, P.; Schulz-Knappe, P.; Baggiolini, M.; Forssmann, W. G. and Magert, H. J. (1998): HCC-2, a human chemokine: gene structure, expression pattern, and biological activity, Proc Natl Acad Sci U S A 95 [11], pp.6308-13. PM=9600961

[81] Lalor, P. F. and Adams, D. H. (1999): Adhesion of lymphocytes to hepatic endothelium, Mol Pathol 52 [4], pp.214-9. PM=10694942

[82] Parker, G. A. and Picut, C. A. (2005): Liver immunobiology, Toxicol Pathol 33 [1], pp.52-62. PM=15805056

[83] Calne, R. Y. (2000): Immunological tolerance--the liver effect, Immunol Rev 174, pp.280-2. PM=10807523

[84] Callery, M. P.; Kamei, T. and Flye, M. W. (1989): The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding, J Surg Res 46 [4], pp.391-4. PM=2784839

[85] Huang, L.; Soldevila, G.; Leeker, M.; Flavell, R. and Crispe, I. N. (1994): The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo, Immunity 1 [9], pp.741-9. PM=7895163

[86] Schlitt, H. J.; Kanehiro, H.; Raddatz, G.; Steinhoff, G.; Richter, N.; Nashan, B.; Ringe, B.; Wonigeit, K. and Pichlmayr, R. (1993): Persistence of donor lymphocytes in liver allograft recipients, Transplantation 56 [4], pp.1001-7. PM=7692632

[87] Dahmen, U.; Qian, S.; Rao, A. S.; Demetris, A. J.; Fu, F.; Sun, H.; Gao, L.; Fung, J. J. and Starzl, T. E. (1994): Split tolerance induced by orthotopic liver transplantation in mice, Transplantation 58 [1], pp.1-8. PM=8036695

[88] Ferber, I.; Schonrich, G.; Schenkel, J.; Mellor, A. L.; Hammerling, G. J. and Arnold, B. (1994): Levels of peripheral T cell tolerance induced by different doses of tolerogen, Science 263 [5147], pp.674-6. PM=8303275

[89] Bertolino, P.; Heath, W. R.; Hardy, C. L.; Morahan, G. and Miller, J. F. (1995): Peripheral deletion of autoreactive CD8+ T cells in transgenic mice expressing H-2Kb in the liver, Eur J Immunol 25 [7], pp.1932-42. PM=7621869

[90] Limmer, A.; Ohl, J.; Kurts, C.; Ljunggren, H. G.; Reiss, Y.; Groettrup, M.; Momburg, F.; Arnold, B. and Knolle, P. A. (2000): Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance, Nat Med 6 [12], pp.1348-54. PM=11100119

[91] Pape, K. A. and Jenkins, M. K. (1998): A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells, Agents Actions Suppl 49, pp.23-31. PM=9426825

[92] Watanabe, T.; Yoshida, M.; Shirai, Y.; Yamori, M.; Yagita, H.; Itoh, T.; Chiba, T.; Kita, T. and Wakatsuki, Y. (2002): Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver, J Immunol 168 [5], pp.2188-99. PM=11859105

[93] Khanna, A.; Morelli, A. E.; Zhong, C.; Takayama, T.; Lu, L. and Thomson, A. W. (2000): Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo, J Immunol 164 [3], pp.1346-54. PM=10640749

[94] Smedsrod, B.; Pertoft, H.; Gustafson, S. and Laurent, T. C. (1990): Scavenger functions of the liver endothelial cell, Biochem J 266 [2], pp.313-27. PM=2156492

[95] Rubinstein, D.; Roska, A. K. and Lipsky, P. E. (1986): Liver sinusoidal lining cells express class II major histocompatibility antigens but are poor stimulators of fresh allogeneic T lymphocytes, J Immunol 137 [6], pp.1803-10. PM=3489042

[96] Lohse, A. W.; Knolle, P. A.; Bilo, K.; Uhrig, A.; Waldmann, C.; Ibe, M.; Schmitt, E.; Gerken, G. and Meyer Zum Buschenfelde, K. H. (1996): Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells, Gastroenterology 110 [4], pp.1175-81. PM=8613007

[97] Tokita, D.; Ohdan, H.; Onoe, T.; Hara, H.; Tanaka, Y. and Asahara, T. (2005): Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes, Transpl Int 18 [2], pp.237-45. PM=15691278

[98] Limmer, A.; Ohl, J.; Wingender, G.; Berg, M.; Jungerkes, F.; Schumak, B.; Djandji, D.; Scholz, K.; Klevenz, A.; Hegenbarth, S.; Momburg, F.; Hammerling, G. J.; Arnold, B. and Knolle, P. A. (2005): Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance, Eur J Immunol. PM=16163670

[99] Knolle, P. A.; Schmitt, E.; Jin, S.; Germann, T.; Duchmann, R.; Hegenbarth, S.; Gerken, G. and Lohse, A. W. (1999): Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells, Gastroenterology 116 [6], pp.1428-40. PM=10348827

[100] Wiegard, C.; Frenzel, C.; Herkel, J.; Kallen, K. J.; Schmitt, E. and Lohse, A. W. (2005): Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells, Hepatology 42 [1], pp.193-9. PM=15962311

[101] Katz, S. C.; Pillarisetty, V. G.; Bleier, J. I.; Shah, A. B. and DeMatteo, R. P. (2004): Liver sinusoidal endothelial cells are insufficient to activate T cells, J Immunol 173 [1], pp.230-5. PM=15210779

[102] Murphy, K. M.; Heimberger, A. B. and Loh, D. Y. (1990): Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo, Science 250 [4988], pp.1720-3. PM=2125367

[103] Barnden, M. J.; Allison, J.; Heath, W. R. and Carbone, F. R. (1998): Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements, Immunol Cell Biol 76 [1], pp.34-40. PM=9553774

[104] Robertson, J. M.; Jensen, P. E. and Evavold, B. D. (2000): DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope, J Immunol 164 [9], pp.4706-12. PM=10779776

[105] Hancock, W. W.; Lu, B.; Gao, W.; Csizmadia, V.; Faia, K.; King, J. A.; Smiley, S. T.; Ling, M.; Gerard, N. P. and Gerard, C. (2000): Requirement of the chemokine receptor CXCR3 for acute allograft rejection, J Exp Med 192 [10], pp.1515-20. PM=11085753

[106] Sligh, J. E., Jr.; Ballantyne, C. M.; Rich, S. S.; Hawkins, H. K.; Smith, C. W.; Bradley, A. and Beaudet, A. L. (1993): Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1, Proc Natl Acad Sci U S A 90 [18], pp.8529-33. PM=8104338

[107] Grusby, M. J.; Johnson, R. S.; Papaioannou, V. E. and Glimcher, L. H. (1991): Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice, Science 253 [5026], pp.1417-20. PM=1910207

[108] Voyta, J. C.; Via, D. P.; Butterfield, C. E. and Zetter, B. R. (1984): Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein, J Cell Biol 99 [6], pp.2034-40. PM=6501412

[109] Sorokin, L.; Girg, W.; Gopfert, T.; Hallmann, R. and Deutzmann, R. (1994): Expression of novel 400-kDa laminin chains by mouse and bovine endothelial cells, Eur J Biochem 223 [2], pp.603-10. PM=8055931

[110] Wagner, E. F. and Risau, W. (1994): Oncogenes in the study of endothelial cell growth and differentiation, Semin Cancer Biol 5 [2], pp.137-45. PM=7520302

[111] Rohnelt, R. K.; Hoch, G.; Reiss, Y. and Engelhardt, B. (1997): Immunosurveillance modelled in vitro: naive and memory T cells spontaneously migrate across unstimulated microvascular endothelium, Int Immunol 9 [3], pp.435-50. PM=9088982

[112] Lyons, A. B. and Parish, C. R. (1994): Determination of lymphocyte division by flow cytometry, J Immunol Methods 171 [1], pp.131-7. PM=8176234

[113] Klugewitz, K.; Topp, S. A.; Dahmen, U.; Kaiser, T.; Sommer, S.; Kury, E. and Hamann, A. (2002): Differentiation-dependent and subset-specific recruitment of T-helper cells into murine liver, Hepatology 35 [3], pp.568-78. PM=11870369

[114] Feil, C. and Augustin, H. G. (1998): Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines, Biochem Biophys Res Commun 247 [1], pp.38-45. PM=9636650

[115] Stryer, L. (1994): Biochemie, 3. ed., Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford, 3-86025-005-1.

[116] Lyck, R.; Reiss, Y.; Gerwin, N.; Greenwood, J.; Adamson, P. and Engelhardt, B. (2003): T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells, Blood 102 [10], pp.3675-83. PM=12893765

[117] Male, D. K.; Pryce, G. and Hughes, C. C. (1987): Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared, Immunology 60 [3], pp.453-9. PM=3106198

[118] Vachiery, N.; Trap, I.; Totte, P.; Martinez, D. and Bensaid, A. (1998): Inhibitory effect of Cowdria ruminantium on the expression of MHC class I and class II molecules on bovine endothelial cells, Ann N Y Acad Sci 849, pp.181-7. PM=9668463

[119] Inaba, M.; Toninelli, E.; Vanmeter, G.; Bender, J. R. and Conte, M. S. (1998): Retroviral gene transfer: effects on endothelial cell phenotype, J Surg Res 78 [1], pp.31-6. PM=9733614

[120] Penfold, P. L.; Wen, L.; Madigan, M. C.; King, N. J. and Provis, J. M. (2002): Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells, Invest Ophthalmol Vis Sci 43 [9], pp.3125-30. PM=12202538

[121] Knolle, P. A. and Gerken, G. (2000): Local control of the immune response in the liver, Immunol Rev 174, pp.21-34. PM=10807504

[122] Schütt, B. (1992): XXX, medizinische Doktorarbeit, Med. Klinik des Universitätskrankenhauses Hamburg Eppendorf, Abt. Klin. Immunologie: Hamburg.

[123] Marelli-Berg, F. M.; Peek, E.; Lidington, E. A.; Stauss, H. J. and Lechler, R. I. (2000): Isolation of endothelial cells from murine tissue, J Immunol Methods 244 [1-2], pp.205-15. PM=11033033

[124] Knook, D. L. and Sleyster, E. C. (1976): Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation, Exp Cell Res 99 [2], pp.444-9. PM=1269536

[125] Beilhack, A. and Rockson, S. G. (2003): Immune traffic: a functional overview, Lymphat Res Biol 1 [3], pp.219-34. PM=15624439

[126] Roth, S. J.; Carr, M. W.; Rose, S. S. and Springer, T. A. (1995): Characterization of transendothelial chemotaxis of T lymphocytes, J Immunol Methods 188 [1], pp.97-116. PM=8551044

[127] Matheny, H. E.; Deem, T. L. and Cook-Mills, J. M. (2000): Lymphocyte migration through monolayers of endothelial cell lines involves VCAM-1 signaling via endothelial cell NADPH oxidase, J Immunol 164 [12], pp.6550-9. PM=10843714

[128] Wetzel, A.; Chavakis, T.; Preissner, K. T.; Sticherling, M.; Haustein, U. F.; Anderegg, U. and Saalbach, A. (2004): Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18), J Immunol 172 [6], pp.3850-9. PM=15004192

[129] Reiss, Y.; Hoch, G.; Deutsch, U. and Engelhardt, B. (1998): T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells, Eur J Immunol 28 [10], pp.3086-99. PM=9808177

[130] Johnson-Leger, C. A.; Aurrand-Lions, M.; Beltraminelli, N.; Fasel, N. and Imhof, B. A. (2002): Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration, Blood 100 [7], pp.2479-86. PM=12239159

[131] Alenius, E. (2001): Evaluation of human endothelial-like ECV304 cells and immortalized mouse brain endothelial bEnd5 cells in co-cultures with rat glioma C6 cells as in vitro models of the blood-brain barrier., Examensarbeit, Department für Pharmakologie und Klinische Neurowissenschaft: Umeå Universität Umeå, Schweden. http://www.umu.se/pharm-neuro/inst/Stig.html">http://www.umu.se/pharm-neuro/inst/Stig.html

[132] Granholm, S. (2001): Investigation of the expression of tight junctions and functional P-glycoproteins in two different in vitro models of the blood-brain barrier, Examensarbeit, Department für Pharmakologie und Klinische Neurowissenschaft: Umeå Universität Umeå, Schweden.

[133] Williams, R. L.; Courtneidge, S. A. and Wagner, E. F. (1988): Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene, Cell 52 [1], pp.121-31. PM=3345558

[134] Williams, R. L.; Risau, W.; Zerwes, H. G.; Drexler, H.; Aguzzi, A. and Wagner, E. F. (1989): Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment, Cell 57 [6], pp.1053-63. PM=2736622

[135] Xu, B.; Broome, U.; Uzunel, M.; Nava, S.; Ge, X.; Kumagai-Braesch, M.; Hultenby, K.; Christensson, B.; Ericzon, B. G.; Holgersson, J. and Sumitran-Holgersson, S. (2003): Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis, Am J Pathol 163 [4], pp.1275-89. PM=14507637

[136] Hallmann, R.; Horn, N.; Selg, M.; Wendler, O.; Pausch, F. and Sorokin, L. M. (2005): Expression and function of laminins in the embryonic and mature vasculature, Physiol Rev 85 [3], pp.979-1000. PM=15987800

[137] Durieu-Trautmann, O.; Chaverot, N.; Cazaubon, S.; Strosberg, A. D. and Couraud, P. O. (1994): Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells, J Biol Chem 269 [17], pp.12536-40. PM=7909803

[138] Etienne, S.; Adamson, P.; Greenwood, J.; Strosberg, A. D.; Cazaubon, S. and Couraud, P. O. (1998): ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells, J Immunol 161 [10], pp.5755-61. PM=9820557

[139] Adamson, P.; Etienne, S.; Couraud, P. O.; Calder, V. and Greenwood, J. (1999): Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway, J Immunol 162 [5], pp.2964-73. PM=10072547

[140] Ilan, N.; Mahooti, S.; Rimm, D. L. and Madri, J. A. (1999): PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin, J Cell Sci 112 Pt 18, pp.3005-14. PM=10462517

[141] Phillips, R. and Ager, A. (2002): Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells, Eur J Immunol 32 [3], pp.837-47. PM=11870628

[142] Lalor, P. F.; Edwards, S.; McNab, G.; Salmi, M.; Jalkanen, S. and Adams, D. H. (2002): Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells, J Immunol 169 [2], pp.983-92. PM=12097405

[143] Bono, P.; Jalkanen, S. and Salmi, M. (1999): Mouse vascular adhesion protein 1 is a sialoglycoprotein with enzymatic activity and is induced in diabetic insulitis, Am J Pathol 155 [5], pp.1613-24. PM=10550318

[144] Mehal, W. Z.; Juedes, A. E. and Crispe, I. N. (1999): Selective retention of activated CD8+ T cells by the normal liver, J Immunol 163 [6], pp.3202-10. PM=10477588

[145] Emoto, M.; Mittrucker, H. W.; Schmits, R.; Mak, T. W. and Kaufmann, S. H. (1999): Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells, J Immunol 162 [9], pp.5094-8. PM=10227978

[146] Miyamoto, M.; Emoto, M.; Brinkmann, V.; van Rooijen, N.; Schmits, R.; Kita, E. and Kaufmann, S. H. (2000): Cutting edge: contribution of NK cells to the homing of thymic CD4+NKT cells to the liver, J Immunol 165 [4], pp.1729-32. PM=10925248

[147] Emoto, M.; Miyamoto, M.; Namba, K.; Schmits, R.; Van Rooijen, N.; Kita, E. and Kaufmann, S. H. (2000): Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver, Eur J Immunol 30 [10], pp.3049-56. PM=11069089

[148] Gilat, D.; Hershkoviz, R.; Mekori, Y. A.; Vlodavsky, I. and Lider, O. (1994): Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta, J Immunol 153 [11], pp.4899-906. PM=7525718

[149] Amara, A.; Lorthioir, O.; Valenzuela, A.; Magerus, A.; Thelen, M.; Montes, M.; Virelizier, J. L.; Delepierre, M.; Baleux, F.; Lortat-Jacob, H. and Arenzana-Seisdedos, F. (1999): Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine, J Biol Chem 274 [34], pp.23916-25. PM=10446158

[150] Rot, A. (2003): In situ binding assay for studying chemokine interactions with endothelial cells, J Immunol Methods 273 [1-2], pp.63-71. PM=12535798

[151] Hadley, T. J. and Peiper, S. C. (1997): From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen, Blood 89 [9], pp.3077-91. PM=9129009

[152] Iwai, Y.; Terawaki, S.; Ikegawa, M.; Okazaki, T. and Honjo, T. (2003): PD-1 inhibits antiviral immunity at the effector phase in the liver, J Exp Med 198 [1], pp.39-50. PM=12847136

[153] Onoe, T.; Ohdan, H.; Tokita, D.; Shishida, M.; Tanaka, Y.; Hara, H.; Zhou, W.; Ishiyama, K.; Mitsuta, H.; Ide, K. and Asahara, T. (2005): Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice, J Immunol 175 [1], pp.139-46. PM=15972640

[154] O'Farrelly, C. (2004): Immunoregulation in the liver and its extrahepatic relevance, J Pediatr Gastroenterol Nutr 39 Suppl 3, pp.S727-8. PM=15167362

[155] Datta, T. and Dormer, P. (1987): Establishment of permanent chimerism in a lactate dehydrogenase-deficient mouse mutant with hemolytic anemia, Exp Hematol 15 [11], pp.1158-62. PM=3315726

[156] Tiberghien, P.; Longo, D. L.; Wine, J. W.; Alvord, W. G. and Reynolds, C. W. (1990): Anti-asialo GM1 antiserum treatment of lethally irradiated recipients before bone marrow transplantation: evidence that recipient natural killer depletion enhances survival, engraftment, and hematopoietic recovery, Blood 76 [7], pp.1419-30. PM=2207317

[157] Jung, U. and Ley, K. (1999): Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin, J Immunol 162 [11], pp.6755-62. PM=10352295

[158] Fillatreau, S. and Gray, D. (2003): T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation, J Exp Med 197 [2], pp.195-206. PM=12538659

[159] Zhang, X.; Giangreco, L.; Broome, H. E.; Dargan, C. M. and Swain, S. L. (1995): Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion, J Exp Med 182 [3], pp.699-709. PM=7650478

[160] Broeren, C. P.; Wauben, M. H.; Lucassen, M. A.; Van Meurs, M.; Van Kooten, P. J.; Boog, C. J.; Claassen, E. and Van Eden, W. (1995): Activated rat T cells synthesize and express functional major histocompatibility class II antigens, Immunology 84 [2], pp.193-201. PM=7750994

[161] Mannie, M. D.; Dawkins, J. G.; Walker, M. R.; Clayson, B. A. and Patel, D. M. (2004): MHC class II biosynthesis by activated rat CD4+ T cells: development of repression in vitro and modulation by APC-derived signals, Cell Immunol 230 [1], pp.33-43. PM=15541717

[162] Pichler, W. J. and Wyss-Coray, T. (1994): T cells as antigen-presenting cells, Immunol Today 15 [7], pp.312-5. PM=7522009

[163] Chang, C. H.; Hong, S. C.; Hughes, C. C.; Janeway, C. A., Jr. and Flavell, R. A. (1995): CIITA activates the expression of MHC class II genes in mouse T cells, Int Immunol 7 [9], pp.1515-8. PM=7495759

[164] Marland, G.; Bakker, A. B.; Adema, G. J. and Figdor, C. G. (1996): Dendritic cells in immune response induction, Stem Cells 14 [5], pp.501-7. PM=8888491

[165] Heath, W. R.; Belz, G. T.; Behrens, G. M.; Smith, C. M.; Forehan, S. P.; Parish, I. A.; Davey, G. M.; Wilson, N. S.; Carbone, F. R. and Villadangos, J. A. (2004): Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens, Immunol Rev 199, pp.9-26. PM=15233723

[166] Reichstetter, S.; Kwok, W. W.; Kochik, S.; Koelle, D. M.; Beaty, J. S. and Nepom, G. T. (1999): MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition, Hum Immunol 60 [7], pp.608-18. PM=10426278

[167] Magnusson, S. and Berg, T. (1989): Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells, Biochem J 257 [3], pp.651-6. PM=2930475

[168] Ma, W. and Pober, J. S. (1998): Human endothelial cells effectively costimulate cytokine production by, but not differentiation of, naive CD4+ T cells, J Immunol 161 [5], pp.2158-67. PM=9725207

[169] Richter, A.; Lohning, M. and Radbruch, A. (1999): Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression, J Exp Med 190 [10], pp.1439-50. PM=10562319

[170] Klugewitz, K.; Blumenthal-Barby, F.; Schrage, A.; Knolle, P. A.; Hamann, A. and Crispe, I. N. (2002): Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization, J Immunol 169 [5], pp.2407-13. PM=12193708

[171] Marelli-Berg, F. M.; Hargreaves, R. E.; Carmichael, P.; Dorling, A.; Lombardi, G. and Lechler, R. I. (1996): Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells, J Exp Med 183 [4], pp.1603-12. PM=8666918

[172] Lodge, P. A. and Haisch, C. E. (1993): T cell subset responses to allogeneic endothelium. Proliferation of CD8+ but not CD4+ lymphocytes, Transplantation 56 [3], pp.656-61. PM=8212163

[173] St Louis, J. D.; Lederer, J. A. and Lichtman, A. H. (1993): Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy, J Exp Med 178 [5], pp.1597-605. PM=7693852

[174] Page, C. S.; Holloway, N.; Smith, H.; Yacoub, M. and Rose, M. L. (1994): Alloproliferative responses of purified CD4+ and CD8+ T cells to endothelial cells in the absence of contaminating accessory cells, Transplantation 57 [11], pp.1628-37. PM=7912014

[175] Marelli-Berg, F. M.; Scott, D.; Bartok, I.; Peek, E.; Dyson, J. and Lechler, R. I. (2000): Activated murine endothelial cells have reduced immunogenicity for CD8+ T cells: a mechanism of immunoregulation?, J Immunol 165 [8], pp.4182-9. PM=11035050


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