[Seite 79↓]

Literaturverzeichnis

Abou Samra, A. B., Jüppner, H., Force, T., Freeman, M. W., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr. et al. (1992) : Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA 89, 2732-2736

Albright, F. (1941) : Case records of the Massachusetts General Hospital (case 27461). N. Engl. J. Med. 225, 789-791

Beigelman, L., McSwiggen, J. A., Draper, K. G., Gonzalez, C., Jensen, K., Karpeisky, A. M., Modak, S., Matulic-Adamic, J., DiRenzo, A. B., Haeberli, P. (1995) : Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J. Biol. Chem. 270, 25702-25708

Beigelman, L., Karpeisky, A., Matulic-Adamic, J., Haeberli, P., Sweedler, D., Usman, N. (1995) : Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes. Nucleic Acids Res. 23, 4434-4442

Brandt, D. W., Wachsman, W., Deftos, L. J., (1994) : Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines. Cancer Res. 54, 850-853

Broadus, A. E., Mangin, M., Ikeda, K., Insogna, K. L., Weir, E. C., Burtis, W. J., Stewart, A. F. (1988) : Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N. Engl. J. Med. 319, 556-563


[Seite 80↓]

Bunge, A. (1997) : Autokrine Effekte von Parathormon-verwandtem Protein (PTHrP) auf invasionsassoziierte Proteasen in Tumorzellinien.Diss., Berlin, Humboldt-Universität

Burtis, W. J., Wu, T., Bunch, C., Wysolmerski, J. J., Insogna, K. L., Weir, E. C., Broadus, A. E., Stewart, A. F. (1987) : Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J. Biol. Chem. 262, 7151-7156

Burton, P. B., Moniz, C. and Knight, D. E. (1990) : Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma. Biochem. Biophys. Res. Commun. 167, 1134-1138

Buzayan, J. M., van Tol, H., Feldstein, P. A., Bruening, G. (1990) : Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA. Nucleic Acids Res. 18, 4447-4451

Cantor, G. H., McElwain, T. F., Birkebak, T. A., Palmer, G. H. (1993) : Ribozyme cleaves rex/tax mRNA and inhibits bovine leukemia virus expression.Proc. Natl. Acad. Sci. USA 90, 10932-10936

Cech, T. R. (1986) : RNA as an enzyme. Sci. Am. 255, 64-75

Cotten, M., Birnstiel, M. L. (1989) : Ribozyme mediated destruction of RNA in vivo. EMBO J. 8, 3861-3866


[Seite 81↓]

Cotten, M. (1990) : The in vivo application of ribozymes. Trends Biotechnol. 8, 174-178

Denman, R. B., Smedman, M., Ju, W., Rubenstein, R., Potempska, A., Miller, D. L. (1994) : Ribozyme mediated degradation of beta-amyloid peptide precursor mRNA in COS-7 cells. Nucleic Acids Res. 22, 2375-2382

Denman, R. B. (1993) : Cleavage of full-length beta APP mRNA by hammerhead ribozymes. Nucleic Acids Res. 21, 4119-4125

Eckstein, F. (1985) : Nucleoside phosphorothioates. Annu. Rev. Biochem. 54, 367-402

Fedor, M. J., Uhlenbeck, O. C. (1990) : Substrate sequence effects on "hammerhead" RNA catalytic efficiency. Proc. Natl. Acad. Sci. USA 87, 1668-1672

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., Danielsen, M. (1987) : Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84, 7413-7417

Forster, A. C., Symons, R. H. (1987) : Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites. Cell 49, 211-220

Goodchild, J. (1992) : Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation. Nucleic Acids Res. 20, 4607-4612


[Seite 82↓]

Goodchild, J. (1990) : Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties. Bioconjug. Chem. 1 , 165-187

Guo, J., Iida-Klein, A., Huang, X., Abou-Samra, A. B., Segre, G. V., Bringhurst, F. R. (1995) : Parathyroid hormone (PTH)/PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells. Endocrinology 136, 3884-3891

Hampel, A., Tritz, R. (1989) : RNA catalytic Properties of the minimum (-) sTRSV sequence. Biochemistry 28, 4929-4933

Haseloff, J., Gerlach, W. L. (1988) : Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334, 585-591

Heidenreich, O., Eckstein, F. (1992) : Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1. J. Biol. Chem. 267, 1904-1909

Helene, C., Toulme, J. J. (1990) : Specific regulation of gene expression by antisense, sense and antigene nucleic acids.Biochim. Biophys. Acta. 1049, 99-125

Hendry, P., McCall, M. J., Santiago, F. S., Jennings, P. A. (1992) : A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability. Nucleic Acids Res. 20, 5737-5741

Hendry, P., McCall, M. J., Santiago, F. S., Jennings, P. A. (1995a): In vitro activity of minimised hammerhead ribozymes. Nucleic Acids Res. 23, 3922-3927


[Seite 83↓]

Hendry, P., McCall, M. J. (1995b): A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes. Nucleic Acids Res. 23, 3928-3936

Hendry, P., McCall, M. (1996) : Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes. Nucleic Acids Res. 24, 2679-2684

Ikeda, K., Mangin, M., Dreyer, B. E., Webb, A. C., Posillico, J. T., Stewart, A. F., Bander, N. H., Weir, E. C., Insogna, K. L., Broadus, A. E. (1988) : Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. J. Clin. Invest. 81, 2010-2014

Jankowsky, E., Schwenzer, B. (1996) : Efficient improvement of hammerhead ribozyme mediated cleavage of long substrates by oligonucleotide facilitators. Biochemistry 35, 15313-15321

Jankowsky, E., Schwenzer, B. (1998) : Oligonucleotide facilitators enable a hammerhead ribozyme to cleave long RNA substrates with multiple-turnover activity. Eur. J. Biochem. 254, 129-134

Kobayashi, H., Dorai, T., Holland, J. F., Ohnuma, T. (1994) : Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme. Cancer Res. 54, 1271-1275

Kovacs, C. S., Chik, C. L., Li, B., Karpinski, E., Ho, A. K. (1995) : Inhibition of serine/threonine protein phosphatases enhances agonist-stimulated cAMP ac-cumulation in UMR 106 osteoblast-like cells. Mol. Cell Endocrinol. 110, 9-16


[Seite 84↓]

Lange, W., Daskalakis, M., Finke, J., Dolken, G. (1994) : Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs. FEBS Lett. 338, 175-178

L'Huillier, P. J., Davis, S. R., Bellamy, A. R. (1992) : Cytoplasmic delivery of ribozymes leads to efficient reduction in alpha-lactalbumin mRNA levels in C127I mouse cells. EMBO J. 11, 4411-4418

Malone, R. W., Felgner, P. L., Verma, I. M. (1989) : Cationic liposome-mediated RNA transfection. Proc. Natl. Acad. Sci. USA 86, 6077-6081

Mangin, M., Ikeda, K., Dreyer, B. E., Broadus, A. E. (1989) : Isolation and characterization of the human parathyroid hormone-like peptide gene. Proc. Natl. Acad. Sci. USA 86, 2408-2412

Martin, T. J., Allan, E. H., Caple, I. W., Care, A. D., Danks, J. A., Diefenbach-Jagger, H., Ebeling, P. R., Gillespie, M. T., Hammonds, G., Heath, J. A., Hudson, P. J., Kemp, B.E., Kubota, M., Kukreja, S. C., Moseley, J. M., Ng, K. W., Raisz, L. G., Rodda, C. P., Simmons, H. A., Suva, L. J., Wettenhall, R. E. H., Wood, W. l. (1989) : Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action. Recent. Prog. Horm. Res. 45, 467-506

McCall, M. J., Hendry, P., Jennings, P. A. (1992) : Minimal sequence requirements for ribozyme activity. Proc. Natl. Acad. Sci. USA. 89, 5710-5714

McConnell, T. S. (1997) : Theoretical considerations in measuring reaction parameters. Methods Mol. Biol. 74, 187-198


[Seite 85↓]

Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E. H., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., Zajac, J. D., Martin, T. J. (1987) : Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc. Natl. Acad. Sci. USA 84, 5048-5052

Nakamura, M., Hashimoto, T., Furuyama, J., Kakudo, K. (1995) : Multiple alternative splice isoforms of parathyroid hormone-related peptide mRNA in human cell lines. J. Mol. Endocrinol. 15, 245-249

Nesbitt, S., Goodchild, J. (1994) : Further studies on the use of oligonucleotide facilitators to increase ribozyme turnover. Antisense Res. Dev. 4, 243-249

Paolella, G., Sproat, B. S., Lamond, A. I. (1992) : Nuclease resistant ribozymes with high catalytic activity. EMBO J. 11, 1913-1919

Perreault, J. P., Wu, T. F., Cousineau, B., Ogilvie, K. K., Cedergren, R. (1990) : Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity. Nature 344, 565-567

Perriman, R., Delves, A., Gerlach, W. L. (1992) : Extended target-site specificity for a hammerhead ribozyme. Gene 113, 157-163

Pieken, W. A., Olsen, D. B., Benseler, F., Aurup, H., Eckstein, F. (1991) : Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes. Science 253, 314-317

Potter, P. M., Harris, L. C., Remack, J. S., Edwards, C. C., Brent, T. P. (1993) : Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.Cancer Res. 53, 1731-1734


[Seite 86↓]

Ruffner, D. E., Uhlenbeck, O. C. (1990) : Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction. Nucleic Acids Res. 18, 6025-6029

Sawata, S., Shimayama, T., Komiyama, M., Kumar, P. K., Nishikawa, S., Taira, K. (1993) : Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various di-valent metal ions. Nucleic Acids Res. 21, 5656-5660

Scanlon, K. J., Jiao, L., Funato, T., Wang, W., Tone, T., Rossi, J. J., Kashani-Sabet, M. (1991) : Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc. Natl. Acad. Sci. USA 88, 10591-10595

Sharmeen, L., Kuo, M. Y. P., Dinter-Gottlieb, G., and Taylor, J. (1988) : Antigenomic RNA of human hepatitis delta virus can undergo self-cleavage. J. Virol. 62, 2674-2679

Shimayama, T., Nishikawa, F., Nishikawa, S., Taira, K. (1993) : Nuclease-resistant chimeric ribozymes containing deoxyribonucletides and phosphorothioate linkages. Nucleic Acids Res. 21, 2605-2611

Sioud, M., Natvig, J. B., Forre, O. (1992) : Preformed ribozyme destroys tumour necrosis factor mRNA in human cells. J. Mol. Biol. 223, 831-835

Snyder, D. S., Wu, Y., Wang, J. L., Rossi, J. J., Swiderski, P., Kaplan, B. E., Forman, S. J. (1993) : Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood 82, 600-605


[Seite 87↓]

Southby, J., Kissin, M. W., Danks, J. A., Hayman, J. A., Moseley, J. M., Henderson, M. A., Bennett, R. C., Martin, T. J. (1990) : Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res. 50, 7710-7716

Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R. F., Leung, S. C., Rosenblatt, M., Nissenson, R. A. (1987) : Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J. Clin. Invest. 80, 1803-1807

Taylor, N. R., Kaplan, B. E., Swiderski, P., Li, H., Rossi, J. J. (1992) : Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo. Nucleic Acids Res. 20, 4559-4565

Turzynski, A., Struckhoff, G., Colangelo, D., Guidotto, S., Dietel, M. (1996) : Parathyroid hormone-related protein (PTHrP) - a paracrine factor in astrocytes and an autocrine factor in astrocytomas.In: Krisch, B., Mentlein, R., eds. The Peptidergic Neuron. Basel/Switzerland, Birkhäuser Verlag, 343-351

Tuschl, T., Eckstein, F. (1993) : Hammerhead ribozymes: importance of stem-loop II for activity. Proc. Natl. Acad. Sci. USA 90, 6991-6994

Uhlenbeck, O. C. (1987) : A small catalytic oligoribonucleotide. Nature 328, 596-600

Yang, J. H., Usman, N., Chartrand, P., Cedergren, R. (1992) : Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain. Biochemistry 31, 5005-5009


[Seite 88↓]

Yasuda, T., Banville, D., Hendy, G. N., Goltzman, D. (1989) : Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects. J. Biol. Chem. 264, 7720-7725


© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
DiML DTD Version 3.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am:
01.09.2004