Entwicklung eines metabolisch stabilen Ribozyms gegen die mRNA des Parathormon-verwandten Proteins (PTHrP)Martin Schultz 191.110623#2731.21112624#316132142.12.1.115162.1.2172.1.32.1.4182.1.5192.1.62.1.720454#226212.1.822615#812.22.2.12.2.2232.2.2.124252.2.2.22.2.2.3262.2.2.42728424#3392.2.3292.2.42.2.4.1302.2.4.2302.2.4.3312.2.4.4322.2.52.2.6332.2.7342.2.8352.2.8.1599#4102.2.8.236372.2.93383.1385#256409#26039340#5403.2403.2.1516#34441538#3853.2.242516#344825#2943.2.343650#4603.2.444523#34845514#34246432#6213.2.547484#321823#2923.2.648516#34449422#3023.2.749824#2913.2.850513#3413.351510#340536#3813.452520#3463.53.5.153584#418584#4183.5.254584#41855584#4184564.15712#2212#2212#224.2585960614.2.162624.2.263459#25064654.2.34.2.3.1664.2.3.24.2.3.3674.2.3.4684.2.469623#62370714.2.572486#277734.34.4744.575764.677578 Literaturverzeichnis79808182838485868788AbkürzungenEidesstattliche VersicherungCurriculum vitaeDanksagungdeInhaltsverzeichnisHilfe Literaturverzeichnis Abou Samra, A. B., Jüppner, H., Force, T., Freeman, M. W., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr. et al. (1992) : Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA 89, 2732-2736 Albright, F. (1941) : Case records of the Massachusetts General Hospital (case 27461). N. Engl. J. Med. 225, 789-791 Beigelman, L., McSwiggen, J. A., Draper, K. G., Gonzalez, C., Jensen, K., Karpeisky, A. M., Modak, S., Matulic-Adamic, J., DiRenzo, A. B., Haeberli, P. (1995) : Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J. Biol. Chem. 270, 25702-25708 Beigelman, L., Karpeisky, A., Matulic-Adamic, J., Haeberli, P., Sweedler, D., Usman, N. (1995) : Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes. Nucleic Acids Res. 23, 4434-4442 Brandt, D. W., Wachsman, W., Deftos, L. J., (1994) : Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines. Cancer Res. 54, 850-853 Broadus, A. E., Mangin, M., Ikeda, K., Insogna, K. L., Weir, E. C., Burtis, W. J., Stewart, A. F. (1988) : Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N. Engl. J. Med. 319, 556-563 Bunge, A. (1997) : Autokrine Effekte von Parathormon-verwandtem Protein (PTHrP) auf invasionsassoziierte Proteasen in Tumorzellinien.Diss.,

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