[Seite 74↓]

Literaturverzeichnis

1 Hubert HB., Feinleib M., McNamara PM et al: Framingham-Studie: Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation 1983, 67, 968-977

2 Braunwald, E. (ed.): Heart Disease: A Textbook of Cardiovascular Medicine . Philadelphia : WB Saunders Co. , 1980

3 Packer M, Bristow MR et al: Effect of carvediol on the survival of patients with chronic heartfailure. Circulation 92 (suppl. 8), Abstr.  0673

4 Swynghedauw B: Development and functional adaption of contractile protein in cardiac and skeletal muscles. Physiol. Rev. 1986, 66, 710-730

5 Katz A: Cellular mechanisms in congestive heart failure. Am. J. Cardiology 1988, 62, 3A-8A

6 Eichhorn EJ, Bristow MR: Medical therapy can improve the biological properties of chronically failing heart. Circulation 1996, 94, 2285-2296

7 Blaufarb IS, Sonnenblick EH: The Renin-Angiotensin System in leftventricular Re-modeling. Am. J. Cardiology 1996, 27, 8C-16C

8 Colucci WS: Molecular and cellular mechanismus of myocardial failure. Am. J. Cardiology 1997, 80, 15L-25L

9 Bristow MR: Mechanism of action of beta-blocking agents in heart failure. Am. J. Cardiology 1997, 80, 26L-40L

10 Holtz J: Role of ACE-inhibition or AT1-blockade in the remodeling following myocardial Infarction. Basic Res. Cardiology 1998, 93, 92-100

11 Ball AM, Sole MJ: Oxidative stress and the pathogenesis of heart failure. Cardiol. Clin. 1998, 16, 7-18

12 Singal PK, Khaper N, Palace V et al: The role of oxidative stress in the genesis of heart disease. Cardiovasc. Res. 1998, 40, 426-432


[Seite innerhalb Literaturhinweis 75↓]

13 McMurray J, Chopra M: Influence of ACE-Inhibitors on free radicals and reperfusion injury: pharmacological curiosity or therapetic hope. Br. J. Clin. Pharmacol. 1991, 31, 373-379

14 Sobotka PA, Gupka DK, Lansky DM et al: Breath pentane is a marker of acute cardiac allograft rejection. J. Heart & Lung Transplant. 13, 1994, 224-229

15 Diaz-Velez CR, Paolasso EA, Piegas LS et al: Metabolic modulation of acute myocardial infarction. The ECLA (Estudias Cardiologios Latinoamerica) Collaborative Group Circulation 1998, 2227-2234

16 Diaz-Velez CR, Garcia-Castniecras S, Mendoza-Ramos E et al: Increased malondialdehyde in peripheral blood of patients with congestive heart failure. Am. Heart Journal 1996, 131, 146-152

17 Keith M, Geranmayegau A, Sole MJ et al: Increased oxidative stress in patients with congestive heart failure. J. Am. Coll. Cardiol. 1998, 31, 1352-1356

18 Yucel D, Aydogdu S, Cehreli S et al: Incerased oxidative stress in dilated cardiomyopathie heart failure. Clin. Chem. 1998, 44, 148-154

19 Mallat Z, Philip I, Lebret M: Elevated levels of 8-iso-prostaglandin-F2-alpha in pericardial fluid of patients with heart failure. Circulation 1998, 97, 1536-1539

20 Schimke I, Müller J, Pfriem F, et al: Decreased oxidative stress in patients with ideopathic dilated cardiomyopathy one year after immunglobulin adsorption. Am. Coll. Cardiol. 2001, 38 , 178-183

21 Xi L, Hess ML, Kukreja RC: Ischemic preconditioning in isolated perfused mouse heart: reduction in infarct size without improvement of postischemic ventricular function. Moll. Cell. Biochem. 1998, 186, 69-77

22 Schimke I, Schikora M, Meyer R et al: Oxidative stress in the human heart is associated with changes in the antioxidative defense as shown after heart transplantation. Mol. Cell. Cardiol. 2000, 204, 89-96

23 Lefer DJ, Granger DN: Oxidative stress and cardiac disease. Am. J. Med. 2000, 109, 315-323


[Seite innerhalb Literaturhinweis 76↓]

24modifiziert nach Pryor WA: Oxy-radicals and related species: Their formation, lifetime and reactions. Am. Rev. Physiolol. 1986, 48, 657-667

25 Tyler DD: Polargraphic assay and intracellular distribution of superoxide dismutase in rat liver . Biochem. J. 1975, 147, 493-504

26 Flaherty JT, Weisfeldt ML: Reperfusion injury-free radicals. Bio. Med. 1988, 5, 409-419

27 Eddy LJ, Stewart JR, Jones HP et al: Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts. Am. J. Physiol. 1987, 253, H 709-711

28 Jarasch ED, Bruder G, Heid HW: Significance of xanthine oxidase in capillary endothel cells. Acta Physiol. Scand. 1986, 548, 39-46

29 Scarpa M., Rigo A, Maiorino M et al: Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbat during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study. Biochem. Biophys. Acta 1984, 801, 215-219

30 Schimke I, Haberland A: Sauerstoffradikale u. Herz-Kreislauferkrankungen: Pathoge­netische Mechanismen, therapeutische Möglichkeiten. Z. Kardiologie 1993, 82, 601-609

31Mills GC: J. Biol. Chemie 1957, 229, 189

32 Flohe L, Schlegel W:Glutathione peroxidase IV intracellular distribution of the glutathione peroxidase system in the rat liver. Z. physiol. Chemie 1971, 352, 1401-1410

33 Sharmberger RJ: Proc. Symp. Selenium Environ Ind. Health Found. Pittsburgh, Pa. 1976, 253

34 MERITH-HF study group: Effect of metoprolol CR/XL in chronic heart-failure: Metoprolol CR/XL Randomised intervention Trial in congestive heart failure. Lancet 1999, 353, 2001-2007

35 CIBIS II Investigators and Commitees: The cardiac insufficiency bisoprolol study II: a randomised trial. Lancet 1999, 353, 9-12

36 Ohkawa H, Oshishi N, Yagi K: Analytische Biochemie 1979, 95, 351-358


[Seite innerhalb Literaturhinweis 77↓]

37 Lowry OH, Roseburgh NJ, Farr AL et al: Protein measurement with the Folin phenol reagent. J. Biol. Chemie 1951, 193, 265-275

38 Beauchamp C, Fridovich J: Superoxid dismutase: improved assay and an assay applicable to acrylamid gels. J. Anal. Biochemie 1971, 44, 27-287

39 Mizuno Y: Changes in superoxide dismutase, catalase, glutathion peroxidase and glutathion reductase activities and thiobarbiture acid reactive products levels in early stages of development in dystrophic chickens. Exp. Neur. 1984, 84, 58-73

40 Paglia DE, Valentine WN: Studies on the Quantitative and Qualitative characterisation of erythrocytes glutathion peroxidase. J. Lab. Clin. Med. 1967, 29, 143-148

41 Grech ED et al: Differential free radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. Europ. Heart J, 1991, 12, Abstr. Suppl. 1245

42 Hammond B, Hess ML: The oxygen free redical system: potential mediator of myocardial injury. J. Am. Coll. Cardiol. 1985, 6, 215- 220

43 Kirshenbaum LA, Singal PK: Antioxidant changes in heart hypertrophy: Significance during Hypoxia-reoxygenation injury. Can. J. Physiol. Pharmacology 1992, 10, 1330-1335

44 Kirshenbaum LA, Singal P: Increase in endogenious antioxidant enzymes protects heart against reperfusion injury. Am. Physiolog. 1993, 265, H 484-493

45 Dhalla AK, Singal PK: Antioxidant changes in hypertrophied and failing guinea pig hearts. Am. J. Physiolog. 1994, 266, 1280

46 Gupta M, Gameiro A, Singal PK: Reduced vulnerability of the hyperthrophied rat heart to oxygen radical injury. Can. J. Physiolog.-Pharmacology 1987, 6, 1157-1167

47 Kharper et al: Effects of afterload-reducing drugs on pathogenesis of antioxidant changes and congestive heart failure in rats. J. Am. Coll. Cardiol. 1997, 29, 856-861

48 Bönner G: Kinine und ACE-Hemmer, Arcis Verlag München 1994, entnommen aus der wissenschaftlichen Basisbroschüre „Vesdil“ der Firma ASTRA GmbH , Stand 08/96, Seite 9


[Seite innerhalb Literaturhinweis 78↓]

49 Kaneko M, Singal PK, Dhalla NS: Alterations in heart sacrolemma Ca2+ -ATPase and Ca2+ binding activities due to oxygen free radicals. Basic Rescue Cardiol. 1990, 85, 45-54

50 Mira ML, Silva MM, Queiroz MJ et al: Angiotensin converting enzymes inhibitors as oxygen free radical scavengers. Free Radical Rescue Commun 1993, 19, 173-181

51 Mak IT, Wiglicki WB: Protection by beta blocking agents against free radical mediated lipid peroxydation. Circ. Res. 1988, 63, 262-266

52 Packer M: The neurohumoral hypothesis: a theory to explain the mechanism of disease progression in heart failure. J. Am. Cardiol. 1992, 20, 248-254

53 Packer M, Cohn CJ: Consensus recommendations for heart failure. Am. J. Cardiol. 1999, 83, 1A-38 A

54 Vogt A, Unterberg C, Kreuzer H: Acute effects of the new angiotensin converting enzyme inhibitor ramipril on hemodynamics and carotid sinus baroreflex activity in congestive heart failure. Am. J. Cardiol., 59, 149 D-154 D

55 Martin-Nero JA, Pintya AO, Gallo L et al: Abnormal baroreflex control of heart rate in decompensated congestive heart failure a. reversal after compensation. Am. J. Cardiol. 67, 604-610

56 The SOLVD Investigastors: Effects of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. New Engl. J. Med. 327, 685-691

57 GISSI 3: Gruppo Italiano per lo Studio della soprawivenza nell Infarcto Micardico: Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6 week mortality and ventricular function after acute myocardial infarction. Lancet 1994, 343, 1115-1122

58 ISIS 4 (Fourth interational Study on Infarct Survival) Collaborative Group 1995: A randomised factorial trial assessing early oral captopril, oral mononitrat and intravenosus magnesium aulphate in 58050 patients with suspected acute myocardial infarction. Lancet 1995, 345, 669-685

59 Burnier M, Brunner HR: Angiotensin II rezeptor antagonist. Lancet 2000, 355, 293-302


[Seite innerhalb Literaturhinweis 79↓]

60 ELITE I+II (Evaluation of Losertan in the Eldery Study), Pitt B et al: Randomised trial of losertan versus captopril in patients over 65 with heart failure. Lancet 1997, 349, 747-752

61 Pitt B, Pool-Wilson PA, Segal R et al: Effect of losertan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial – The Losertan Heart Failure Survival Study Elite II. Lancet 2000, 355, 1582-1587

62 Chadda K, Goldstein S, Byington R et al: Effect of propanolol after myocardial infarction in patients with heart failure. Circulation 1986, 73, 503-510

63 Sigmund M, Hanroth P: Betarezeptorenblocker bei chron. Herzinsuffizienz. Z. Kardiologie 1995, 84, 820-826

64 Hennersdorf M, Perings C, Vester EG: Hemodynamic effects of celiprolol in patients with ischemic and non ischemic cardiomyopathie. Int. J. Cardiol. 1999, 68, 289-295

65 MDC-Trail: Waagstein F, Bristow MR, Swedberg K et al: Metoprolol in dilated cardiomyopathie trial study group 1993: Beneficial effects of metoprolol in idiopathic dilated cardiomyopathie. Lancet 1993, 342, 1441-1446

66 Packer M, Bristow MR, Collucci WS et al: US-Carvedilol Heart Failure Study Group 1996: The effect of carvedilol on morbiditiy and mortality in patients with chronic heart failure. N. Engl. J. Med. 1996, 334, 1349-1355

67 Australia/New Zealand Heart failure Research: Randomized, placebo controlled trial of carvedilol in patients with congestive heart failure due to the ischemic heart disease. Lancet 1997, 349, 375-380

68 Gutteridge JMC: Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem. 1995, 41, 1819-1828

69 Ji LL: Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 1999, 222, 283-292

70 Armstrong D, Browne R: The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds to oxidative stress as applied to the clinical chemistry laboratory. Adv. Exp. Bio. Med. 1994, 366, 43-58


[Seite innerhalb Literaturhinweis 80↓]

71 Shimitzu T, Kondo K, Hayaishi O: Role of prostaglandin endoperoxides in the serum TBA-reaction. Arch Biochem. Biophys. 1981, 206, 271-276

72 Schimke I, Papies B: Einige methodische Aspekte der Bestimmung thiobarbitursäure-reaktiver Substanzen im Plasma. Z. med. Lab. Diagnostik 1986, 27, 71-75

73 Janero DR: Malondialdehyde and thiobarbituric acid-reactivity as diagnostic incidences of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med. 1990, 9, 515-540

74 Liedtke AJ, Mahar CQ, Ytrehus K et al: Estimates of free-radical production in rat and swine hearts: method and application of measuring malondialdehyde levels in fresh and frozen myocardium. Basic Res. Cardiol. 1984, 79, 513-518

75 Buege J, Aust SD: Microsomal lipid peroxidation. Methods Enzymol. 1978, 52, 302-310

76 Schimke I: Tierexperimentelle und klinisch-chemische Untersuchungen zum Stoffwechsel der O2 -Radikale bei Herz-Kreislauf-Krankheiten. Habilitationsschrift, Berlin 1987

77 McCord JM, Crapo JD, Fridivich I: Superoxide dismutase assay: a review of Meto-dology. In: Michelson AM, McCord JM, Fridovich I (eds): Superoxide and superoxide dismutases. Academic press, London, NY, San Francisco 1977, 11-17

78 Lengfelder E, Elstner EF: Cyanide insensitive iron superoxide dismutase in euglelia gracilis. Comparison of Reliability of different test systems for superoxide dismutase. Z. Naturforsch. 1979, 34c, 374-380

79 Schikora M: Untersuchungen zum myokardialen Sauerstoffradikal-Stoffwechsel von Patienten mit terminaler Herzinsuffizienz und Patienten nach Herztransplantation. Dissertation, Berlin

80 Oberley LW, Spitz DR: Assay of superoxide dismutase activity in tumor tissue. Methods Enzymol. 1984, 105, 457-464

81Carmagnol F, Sinet PM, Jerome H: Selenium-dependent and non-selenium-dependent glutathion peroxidases in human tissue extracts. Biochem. Biophys. Acta 1983, 759, 49-57


[Seite innerhalb Literaturhinweis 81↓]

82 Garcia-Bunnel L: Lipid peroxidation in alcohol myopathy and cardiomyopathie. Med. Hypotheses 1984, 13, 217-231

83 Nordman R, Ribiere C, Rouch H: Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcoholm 1990, 25, 231-237

84 Jiang JP, Downing SE: Catecholamine cardiomyopathy: review and analysis of patho-genetic mechanism. Yale Journal Biol. Med. 1990, 63, 591

85 Singal P, Kapur N, Dhillon KS: Can. Journal Physiology/Pharmacology 1982, 60, 1390-1397

86 Asayama K, Kato K: Oxidative molecular injury and its relevance to hypothyreodism. Free Radic. Biolog. Med. 1990, 8, 293-303

87 Jain SK, Levine SN: Elevated lipid peroxidation and Vit E-chinone levels in heart ventricels of streptotoxin treated diabetic rats. Free Radic Biol. Med. 1995, 337-341

88 Mimnaugh EG, Trush MA, Gram TE: A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity. Biochem. Pharmacol. 1986, 35, 4327-4335

89Iliskovic N, Li T, Khaper N et al: Modulation of adriamycine induced changes in serum free fatty acids, albumin and cardiac oxidative stress. Mol. Cell. Biochem. 1998, 188, 161-166

90 Stroo WE, Schaffer SW: Furazolidone-enhanced production of free radicals by avian cardiac and hepatic microsomal membranes. Toxicol Appl. Pharmacol. 1989, 98, 81-96

91 Fukuchi T, Kobayashi A, Kaneko M: Possible involvement of free radicals and antioxidants in the early stages of the development of cardiomyopathy in BIO 14.6 Syrian hamster. Jpn. Heart Journal 1991, 32, 665-666

92 Nordmann R: Alcohol and antioxidant systems. Alcohol 94, 29, 513-522

93 Edes I, Pries G, Forster T et al: Alcohol-induced congestive cardiomyopathy in adult turkeys: effect on myocardial antioxidant defence system. Basic Res. Cardiol. 1988, 82, 551-556


[Seite innerhalb Literaturhinweis 82↓]

94Am. Heart Association: International Liasion Committee on Resuscitation, ILCOR: Guidelines 2000 for cardiovascular care – an international consensus on science. Circulation 2000, 102, 1-384

95 Flather MD, Yusuf S, Kober L et al: Long term ACE-inhibitor therapy in patient with heart failure or left-ventricular dysfunction: A systematic overview of data from individual patients. Lancet 2000, 355, 1575-1581

96 Zhao MH, Fu W, Yuan W et al: A study of time window for oxidative stress associated with myocardial ischemia and reperfusion. Clin. Med. J. 1996, 109,926-929

97 Zhong P, Li ZL, Wu HC et al: Clinical study of changes of urotensin II in patients with congestive heart failure. Di Xi Jun Yi Da Xue Xue Bao, 2003, 23,121-123

98 Lehmann I, Papies B, Parsi RA et al: Enzyme pattern and lipid peroxides in endomyocardial biopsies from patients with cardiomyopathy and myocarditis. Clin. Chem. Acta 1988, 173, 193-200

99 Clot P, Tabone M, Arico S et al: Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 1994, 35, 1637-1643

100 Schimke I, Schimke E: Plasma concentration of thiobarbituric acid reactive substances (TBARS) in type I diabetics. Diabetes Res. 1992, 21, 65-72

101 Schimke I, Kahl PE, Romaniuk P et al: Concentration of thiobarbituric acid reactive substances (TBARS) in serum following myocardial infarct. Kl. Wochenschrift 1986, 64, 1237-39

102 Singh RB, Niaz MA, Bishoni I et al: Diet, antioxidant vitamins, oxidative stress and risk of coronary artery disease: the Peerzada Prospective Study. Acta Cardiol. 1994, 49, 453-467

103 Meerson FZ, Kagau VE et al: The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart. Basic Res. Cardiol. 1982, 82, 465-485


[Seite innerhalb Literaturhinweis 83↓]

104 Schimke I, Haberland A, With M et al: Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. Prostaglandins, Leucotriens and Essent Fatty Acids 1997, 57, 545-550

105 Theres H, Wagner KD, Schulz S et al: Oxygen radical system in chronic infracted rat heart the effect of combined beta blockade and ACE inhibition. J. Cardiovasc. Pharmacology 2000, 35, 708-715

106 Haberland A, Mader K, Strasser R: Comparisson of malondialdehyde and hydrogen peroxide modified CnZnSOD by EPR spectroscopy. Agents Actions 1993, 40, 266-270

107 Wagner KD, Gmehling G, Gunther J et al: Contractile function of rat myocardium is less suspectible to hypoxia/eoxygenation after acute infarction. Mol. Cell. Biochem. 2001, 228, 49-55

108 Torok B, Roth E, Bar V et al: Effects of antioxidant therapy in experimentally induced heart infarcts. Basic Res. Cardiol. 1986, 81, 167-179

109 Burton KP, Mc Cord JM, Ghai G: Myocardial alteration due to free radical generation. Am. J. Physiol. 1984, 246, H 776-783

110 Blaustein AS, Schine L, Brooks WW: Influence of exogenously generated oxidant species on myocardial function. Am. Journal Physiol. 1986, 250, 595-599

111 Jackson CV, Mickelson JK, Pope TK: O2 free radical-mediated myocardial and vascular dysfunction. Am. J. Physiol. 1986, 251, 1225-1231

112 Goldhaber JI, Weiss JN: Oxygen free radicals and cardiac reperfusion abnormities. Hypertension 1992, 11, S 11

113 Schimke I, Haberland A, Will et al: In vitro effects of reactive oxygen species and the β -receptor-adenylyl-cyclase system. Mol. Cell. Biochemie 1992, 110, 41-46

114 Nakanishi K, Hamada K, Nakamura K et al: Renal hemodyamic interaction of nitric oxide and angiotensin II. (Circulation 1998), Nippon Jinzo Gakki Shi 1998, 40, 567-572

115 Imlay JA, Linn S: DNA-damage and oxygen radical toxicit. Science 1988, 240, 1302-1309

116 Pauletto P, Piccolo D, Scannapieco G et al: Left ventricular hypertrophy in hypertension: Changes in isomyosins and creatine-kinase isoenzymes Am. J. Med. 1988, 84, 122-124


[Seite innerhalb Literaturhinweis 84↓]

117 Singal PK, Khaper N, Kumar D et al: The role of oxidative stress in the genesis of heart disease. Cardiovasc. Res. 1998, 40, 426-432

118 Li PF, Dietz R, von Harsdorf R: Superoxide induces apoptosis in cardiomyocytes by proliferation and expression of transforming growth factor – beta 1 in cardiac fibro-blasts. FEBS Lett. 1999, 448, 206-210

119 White HD, Norris RM, Brown MA et al: Left ventricular and systolic volume as the major determinant of survival after recovery from myocardial infarction. Circlation 1987, 76, 44-51

120 Demopoulos HB, Flamm ES, Pietronigro DD et al: The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol. Scand. 1980, 492, 91-119

121 Nohl H: Generation of superoxideradicals as byproduct of cellular respiration. Ann. Biol. Clin. (Paris) 1994, 94, 199-204

122 Sawyer DB, Collucci WS: Mitochondrial oxidative stress in heart failure “oxygen wastage” revisted. Circulation Res. 2000, 86, 119-120

123 Lucchesi BR, Mullane KM: Leucocytes and ischemia-induced myocardial Injury. Ann. Rev. Pharmacol. Toxicol. 1986, 26, 201-224

124 Singal PK, Kirshenbaum: A reactive deficit in antioxidant reserve may contribute in cardiac failure. Can. J. Cardiol. 1990, 6, 47-49

125 Gupta M et Singal PK: Higher antioxidative capacity during a chronic stable heart hypertrophy. Circul. Res. 1989, 64, 398-406

126 Singal PK, Deally CM, Weiner IE: Subcellular effects of adriamycin in the heart: a concise review. J. Mol. Cell-Cardiol. 1987, 19, 817-828

127 Pfeffer MA, Pfeffer JM, Steinberg C et al: Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Circulation 1985, 72, 406-412


[Seite innerhalb Literaturhinweis 85↓]

128 Yamaguchi F, Sanbe A, Takeo S: Effects of long-term treatment with trandolapril on sacroplasmic reticulum function of cardiac muscle in rats with chronic heart failure following myocardial infarction. Brit. J. Pharmacol. 1998, 123, 326-334

129 Hügel S, Horn M, de Groot M et al: Effects of ACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction. Am. J. Physiol. 1999, 277, H2167-2175

130 Wei S, Chow LT, Sanderson JE et al: Effects of carvedilol in comparison with metoprolol om myocardial collagen post infarction. J. Am. Coll. Cardiol. 2000, 36, 276-281

131 Wagner KD, Geil D, Schimke I et al: Decreased suspectibility of contractile function to hypoxia/reoxygenation in chronic infarcted rat hearts. J. Mol. Cell. Cardiol. 1998, 30, 2341-2353

132 Wagner KD, Theres H, Born AK et al: Contractile function of papillary muscle from rat with different infact size after beta adrenegic blockade and ACE-inhibition. J. Mol. Cell. Cardiol. 1997, 29, 2941-2951

133 Litwin SE, Morgan JP: Captopril enhances intracellular calcium handling and beta-adrenergic responsiveness of myocardium from rats with postinfarction failure. Circulation Res. 1992, 71, 797-807

134 Anversa P, Beghi C, Kikkawa Y et al: Myocardial infaction in rats: Infarct size, myocyte hypertrophy and capillary growth. Circ. Res. 1986, 58, 26-37

135 Wagner KD, Eßmann V, Mydlak K et al: Decreased susceptibility of cardiac function to hypoxia-reoxygenation in renin-angiotensin-transgenic rats. J. Am. Physiol. 2002

136 Kijima K, Matsubara H, Murasawa S et al: Mechanical stretch induces enhanced expression of angiotensin II recteptor subtypes in neonatal rat cardiac myocytes. Circulat. Res. 1996, 79, 887-897

137 Deng XF, Rokosh DG, Simpson PC: Autonomous and growth factor induced hypertrophy in cultured neonatal mouse cardiac myocytes, comparison with rats. Circ. Res. 2000, 87, 781-788


[Seite innerhalb Literaturhinweis 86↓]

138 Pimentel DR, Amin JK, Xiao L et al: Reactive oxygen species mediate amplitude dependent hypertophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res. 2001/2000, 89, 453-460

139 Khaper N, Singal PK: Modulation of oxidative stress by a selective inhibition of angiotensin II type I receptors in MI rats. Am. Col. Cardiol. 2001, 37, 1461-1466

140 Sia YT, Parker TG, Lin P et al: Improved post myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression. J. Am. Coll. Cardiol. 2002, 39, 148-156

141 Hill MF , Singal PK: Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation 1997, 96, 2414-2420

142 Hill MF, Singal PK: Antioxidant and oxidative stress changes during heart failure sussequent to myocardial infarction in rats. Am. J. Patholog. 1996, 148, 291-300

143 Coetzee IH, Lochner A: Free radical effects on myocardial membrane micro-viscosity. Cardioscience 1993, 4, 205-215

144 Kaneko M, Matsumoto Y, Hayashi H et al: Oxygen free radicals and calcium homeostasis in the heart. Mol. Cell. Biochem. 1994, 139, 91-100

145 Siwite DA, Tzotzis JD, Pimental DR et al: Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype and apoptosis in neonatal rat cardiac myocytes in vitro. Circ. Res. 1999, 85, 147-153

146 Donta I, Karayannacos PE et al: Effect of beta-adrenergic blockade on physiologic growth in the Wistar rat. Res. Commun. Chem. Pathol. Pharmacol. 1982, 37, 147-150

147 Rothwell CE, Mc Guire EJ, Martin RA et al: Chronic toxicity and carcinogenicity studies with the beta-adenoceptor antagonist levobulol. Fund. Appl. Toxicol. 1992, 18, 353-359

148 Campbell DJ, Duncan AM, Kladis A et al: Converting enzyme inhibition and its withdrawal in spontaneously hypertensive rats. J. Cardiovasc Pharmacol. 1995, 26, 426-436


[Seite innerhalb Literaturhinweis 87↓]

149 Duncan AM, Burrell LM, Kladis A et al: Effects of angiotensin converting enzyme inhibition on angiotensin and bradykinin peptides in rats with myocardial infarction. Cardiovasc. Pharmacol. 1996, 28, 746-54

150 Toritsuka N, Daimon H, Sawada S et al: Mutagenicity study of gadobenate dimeglumine formation (E 7155) (3) – Micronucleus test in rat bone marrow cells. J. Toxicol. Science 1999, 24, 103-106

151 Schelling P: Angiotensin and cell growth: a link to cardiovascular hypertrophy. Journal Hypertension 1991, 9, 3-15

152 Liu YH, Yang XP, Mehta D et al: Role of kinins in chronic heart failure and in the therapentic effect of ACE inhibitors in kininogen deficient rats. Am. J. Physiol. Heart Circ. Physiol. 2000, 278, 507-514

153 Pinto YM, van Wijngaarden J, van Gilst WH et al: The effects of short and long-term treatment with an ACE-inhibitor in rats with myocardial infarction. Basic Res. Cardiol. 1991, 86, 165-172

154 Gilbert M, Lowes B, Bristow MR, unpubliziert in Eichhorn EJ, Bristow MR: Circulation 1996

155 Vizir VA, Berzin AE: Cardiac failure treatment with berlipril: effects on hemodynamics, neurohumoral status and activity of free radical lipid peroxidation. Ter Arkh 1999, 71, 13-17

156 Mansuy P, Mougenot N, Ramirez-Gil JF et al: Effects of prolonged propanolol treatment on left ventricular remodeling and oxidative stress after myocardial infarction in rats. J. Cardiovasc. Pharmacol. 2000, 35, 806-813

157 Kukin ML, Kalman J, Charney RH et al: Prospective, randomized comparison of effect of long term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction and oxidative stress in heart failure. Circulation 1999, 99, 2645-2651

158 Chopra M, Beswick H, Clapperton M et al: Antioxidant effects of angiotensin-converting enzyme inhibitiors: free radical and oxidant scavenging are sulfhydryl depended, but lipid peroxidation is inhibited by both sulfhydryl containing and non-sulfhydryl containing ACE-inhibitors. J. Cardiovasc. Pharmacol. 1992, 19, 330-340


[Seite innerhalb Literaturhinweis 88↓]

159 Engelmann GL, Dionne CA, Jaye MC: Acidic fibroblast growth factor, heart developement and capillary angiogenesis et al. Ann. NY Acad. Science 1991, 638, 463-466

160 Misik V, Mak IT, Staffort RE et al: Reactions of captopril and epicaptopril with transition metal ions and hydroxyl radicals: an EPR spectroscopy. Free Radic. Biol. Med. 1993, 15, 611-619

161 Suzuki H, Matsumori A, Matoba Y et al: Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. Clin. Invest. 1993, 91, 2727-2733

162 Obata T, Yamanaka Y: Effect of OH scavenging action by non SH-containing angiotensin converting enzyme inhibitor imidaprilat using microdialysis. J. Physiol. Paris 1998, 92, 1-4

163 Yue TL, Cheng HY, Cysko PG et al: Carvedilol, a new vasodilator and β -adrenoreceptor antagonist, is an antioxidant and free radical scavenger. J. Pharmacol. Exp. Therap. 1992, 263, 92-98

164 Napoli C, Ambrosio G et al: Protezione da parte die bloccanti della perossidazione delle lipoprotein umane a bassa densita indotta dai radicali liberi dell ossigeno. G. Ital. Cardiol. 1994, 24, 361-366

165 Munzel T, Hink U, Heizer T et al: Role for NADPH/NADH oxidase in the modulation of vascular tone. Ann. NY. Acad. Science 1999,874, 386-400

166 Griendling KK, Minieri CA et al: Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 1994, 74, 1141-1148

167 Mohazzab KM, Kaminski PM et al: NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am. J. Physiol. 1994, 226, H 2568-2572

168 Prabha PS, Das UN, Koratkar R et al: Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled essential hypertension. Prostaglandins, Leucotriens, Essent Fatty acids 1990, 41, 2-7


[Seite innerhalb Literaturhinweis 89↓]

169 Kumar KV, Das UN et al: Are free radicals involved in the pathobiology of human essential hypertension. Free Radic. Res. Commun. 1993, 19, 59-66

170 Dunzendorfer S, Wiedermann CJ: Modulation of neutrophil migration and superoxide anion release by metoprolol. J. Mol. Cell. Cardiol. 2000, 32,915-924

171 Younes A, Schneider JM et al: Redistribution of creatine kinase isoenzymes in chronically overloaded myocardium. Cardiovasc. Res. 1984, 58, 26-37

172Neubauer S, Horn M, Naumann A et al: Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J. Clin. Invest. 1995, 1092-1100

173 Theres H, Wagner KD, Romberg D et al: Combined treatment with ramipril and metoprolol prevents changes in the creatine kinase isoenzyme system and improves hemodynamic function in rat hearts after myocardial infarction. Cardiovasc. Drugs and Therapy 2000, 14, 597-606

174 Ishikawa K, Hashimoto H et al: Enalapril improves heart failure induced by monocrotaline without reducing pulmonary hypertension in rats: role of preserved myocardial creatine kinase and lactat dehydrogenase isoenzymes. J. Cardiol. 1995, 47, 225-233

175 Neubauer S et al: Long term beta-blocker treatment prevents chronic creatine kinase and lactat dehyrogenase system changes in rat hearts after myocardial infarction. J. Am. Coll. Cardiol. 1996, 27, 487-493

176 Busse R, Flemming I et al: Endothelium-derived bradykinin: implication for angiotensin-coverting enzyme-inhibitor therapy. J. Cardiovasc. Pharmacol. 1993, 22, 31-36

177 Linz W, Wiemer G: Contibution of bradykinine to the cardiovascular effects of ramipril. J. Cardiovasc. Pharmacol. 1995, 25, 440- 447

178 Massoudy P, Becker BF, Gerlach E: Nitric oxide accounts for postischemic cardioprotection resulting from angiotensin-converting-enzym inhibition: indirect evidence for a radical scavenger effect in isolated guinea pig heart. J. Cardiovasc. Pharmacol. 1995, 25, 440-447


[Seite innerhalb Literaturhinweis 90↓]

179 Cheng W, Li B et al: Strech-induced programmed myocyte cell death. J. Clin. Invest. 1995, 96, 2247-2259


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