<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry ref="front" type="front"/><cms:entry ref="N10009" type="pagenumber">1</cms:entry><cms:entry type="title">Beurteilung der linksventrikulären Funktion nach Partieller Ventrikulektomie mittels Stressechokardiographie</cms:entry><cms:entry type="author">Johanna  Seysen</cms:entry><cms:entry ref="N10034" type="pagenumber">2</cms:entry><cms:entry ref="N10050" type="pagenumber">3</cms:entry><cms:entry ref="N1006C" type="pagenumber">4</cms:entry><cms:entry ref="N1009F" type="pagenumber">5</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="_Ref19940971" part="chapter1" ref="_Ref19940971" type="link"/><cms:entry id="N100BF" part="chapter1" ref="N100BF" type="pagenumber">8</cms:entry><cms:entry id="N100D2" part="chapter1" ref="N100D2" type="section">1.1</cms:entry><cms:entry id="N100DA" part="chapter1" ref="N100DA" type="subsection">1.1.1</cms:entry><cms:entry id="N100F3" part="chapter1" ref="N100F3" type="pagenumber">9</cms:entry><cms:entry id="N100FE" part="chapter1" ref="N100FE" type="table"/><cms:entry id="N1018C" part="chapter1" ref="N1018C" type="subsection">1.1.2</cms:entry><cms:entry id="N1019D" part="chapter1" ref="N1019D" type="pagenumber">10</cms:entry><cms:entry id="N101EA" part="chapter1" ref="N101EA" type="section">1.2</cms:entry><cms:entry id="N101EE" part="chapter1" ref="N101EE" type="pagenumber">11</cms:entry><cms:entry id="N101FB" part="chapter1" ref="N101FB" type="table"/><cms:entry id="N10202" part="chapter1" ref="N10202" type="pagenumber">12</cms:entry><cms:entry id="N102A1" part="chapter1" ref="N102A1" type="subsection">1.2.1</cms:entry><cms:entry id="N102AB" part="chapter1" ref="N102AB" type="pagenumber">13</cms:entry><cms:entry id="N102C8" part="chapter1" ref="N102C8" type="section">1.3</cms:entry><cms:entry id="N102CC" part="chapter1" ref="N102CC" type="pagenumber">14</cms:entry><cms:entry id="N102D8" part="chapter1" ref="N102D8" type="subsection">1.3.1</cms:entry><cms:entry id="N102E9" part="chapter1" ref="N102E9" type="subsection">1.3.2</cms:entry><cms:entry id="N10316" part="chapter1" ref="N10316" type="pagenumber">15</cms:entry><cms:entry id="N10356" part="chapter1" ref="N10356" type="subsection">1.3.3</cms:entry><cms:entry id="N10367" part="chapter1" ref="N10367" type="mm">133#35</cms:entry><cms:entry id="N10379" part="chapter1" ref="N10379" type="pagenumber">16</cms:entry><cms:entry id="N1037F" part="chapter1" ref="N1037F" type="mm">12#23</cms:entry><cms:entry id="N103BB" part="chapter1" ref="N103BB" type="pagenumber">17</cms:entry><cms:entry id="N103C9" part="chapter1" ref="N103C9" type="table"/><cms:entry id="N1051C" part="chapter1" ref="N1051C" type="section">1.4</cms:entry><cms:entry id="N10520" part="chapter1" ref="N10520" type="pagenumber">18</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10556" part="chapter2" ref="N10556" type="pagenumber">19</cms:entry><cms:entry id="N1055B" part="chapter2" ref="N1055B" type="section">2.1</cms:entry><cms:entry id="N10583" part="chapter2" ref="N10583" type="table"/><cms:entry id="N1058A" part="chapter2" ref="N1058A" type="pagenumber">20</cms:entry><cms:entry id="N10681" part="chapter2" ref="N10681" type="subsection">2.1.1</cms:entry><cms:entry id="N10685" part="chapter2" ref="N10685" type="pagenumber">21</cms:entry><cms:entry id="N106DA" part="chapter2" ref="N106DA" type="pagenumber">22</cms:entry><cms:entry id="N10765" part="chapter2" ref="N10765" type="pagenumber">23</cms:entry><cms:entry id="N107D1" part="chapter2" ref="N107D1" type="section">2.2</cms:entry><cms:entry id="N107D5" part="chapter2" ref="N107D5" type="pagenumber">24</cms:entry><cms:entry id="N107DA" part="chapter2" ref="N107DA" type="subsection">2.2.1</cms:entry><cms:entry id="N107E3" part="chapter2" ref="N107E3" type="subsection">2.2.2</cms:entry><cms:entry id="N107FF" part="chapter2" ref="N107FF" type="pagenumber">25</cms:entry><cms:entry id="N10809" part="chapter2" ref="N10809" type="table"/><cms:entry id="N10924" part="chapter2" ref="N10924" type="table"/><cms:entry id="N109C0" part="chapter2" ref="N109C0" type="subsection">2.2.3</cms:entry><cms:entry id="N109C4" part="chapter2" ref="N109C4" type="pagenumber">26</cms:entry><cms:entry id="N10A31" part="chapter2" ref="N10A31" type="section">2.3</cms:entry><cms:entry id="N10A35" part="chapter2" ref="N10A35" type="pagenumber">27</cms:entry><cms:entry id="N10A3A" part="chapter2" ref="N10A3A" type="subsection">2.3.1</cms:entry><cms:entry id="N10A47" part="chapter2" ref="N10A47" type="mm">328#295</cms:entry><cms:entry id="N10A56" part="chapter2" ref="N10A56" type="pagenumber">28</cms:entry><cms:entry id="N10A66" part="chapter2" ref="N10A66" type="subsection">2.3.2</cms:entry><cms:entry id="N10A6A" part="chapter2" ref="N10A6A" type="pagenumber">29</cms:entry><cms:entry id="N10A74" part="chapter2" ref="N10A74" type="table"/><cms:entry id="N10B68" part="chapter2" ref="N10B68" type="section">2.4</cms:entry><cms:entry id="N10B6C" part="chapter2" ref="N10B6C" type="pagenumber">30</cms:entry><cms:entry id="N10B71" part="chapter2" ref="N10B71" type="subsection">2.4.1</cms:entry><cms:entry id="N10BBC" part="chapter2" ref="N10BBC" type="pagenumber">31</cms:entry><cms:entry id="N10BCE" part="chapter2" ref="N10BCE" type="subsection">2.4.2</cms:entry><cms:entry id="N10BD3" part="chapter2" ref="N10BD3" type="block">2.4.2.1</cms:entry><cms:entry id="N10BE0" part="chapter2" ref="N10BE0" type="mm">307#21</cms:entry><cms:entry id="N10BEA" part="chapter2" ref="N10BEA" type="mm">276#185</cms:entry><cms:entry id="N10BF9" part="chapter2" ref="N10BF9" type="pagenumber">32</cms:entry><cms:entry id="N10C00" part="chapter2" ref="N10C00" type="mm">175#41</cms:entry><cms:entry id="N10C0A" part="chapter2" ref="N10C0A" type="mm">160#19</cms:entry><cms:entry id="N10C14" part="chapter2" ref="N10C14" type="mm">209#21</cms:entry><cms:entry id="N10C27" part="chapter2" ref="N10C27" type="table"/><cms:entry id="N10C9D" part="chapter2" ref="N10C9D" type="block">2.4.2.2</cms:entry><cms:entry id="N10CA1" part="chapter2" ref="N10CA1" type="pagenumber">33</cms:entry><cms:entry id="N10CAB" part="chapter2" ref="N10CAB" type="mm">231#21</cms:entry><cms:entry id="N10CB5" part="chapter2" ref="N10CB5" type="mm">260#21</cms:entry><cms:entry id="N10CC3" part="chapter2" ref="N10CC3" type="table"/><cms:entry id="N10D61" part="chapter2" ref="N10D61" type="section">2.5</cms:entry><cms:entry id="N10D65" part="chapter2" ref="N10D65" type="pagenumber">34</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N10D82" part="chapter3" ref="N10D82" type="pagenumber">35</cms:entry><cms:entry id="N10D87" part="chapter3" ref="N10D87" type="section">3.1</cms:entry><cms:entry id="N10D90" part="chapter3" ref="N10D90" type="section">3.2</cms:entry><cms:entry id="N10D9E" part="chapter3" ref="N10D9E" type="subsection">3.2.1</cms:entry><cms:entry id="N10DA2" part="chapter3" ref="N10DA2" type="pagenumber">36</cms:entry><cms:entry id="N10DA7" part="chapter3" ref="N10DA7" type="block">3.2.1.1</cms:entry><cms:entry id="N10DB1" part="chapter3" ref="N10DB1" type="table"/><cms:entry id="N10F11" part="chapter3" ref="N10F11" type="mm">175#175</cms:entry><cms:entry id="N10F1C" part="chapter3" ref="N10F1C" type="mm">175#175</cms:entry><cms:entry id="N10F29" part="chapter3" ref="N10F29" type="block">3.2.1.2</cms:entry><cms:entry id="N10F2D" part="chapter3" ref="N10F2D" type="pagenumber">37</cms:entry><cms:entry id="N10F37" part="chapter3" ref="N10F37" type="table"/><cms:entry id="N11097" part="chapter3" ref="N11097" type="table"/><cms:entry id="N111F7" part="chapter3" ref="N111F7" type="subsection">3.2.2</cms:entry><cms:entry id="N111FB" part="chapter3" ref="N111FB" type="pagenumber">38</cms:entry><cms:entry id="N11203" part="chapter3" ref="N11203" type="block">3.2.2.1</cms:entry><cms:entry id="N1120D" part="chapter3" ref="N1120D" type="mm">415#301</cms:entry><cms:entry id="N1121B" part="chapter3" ref="N1121B" type="table"/><cms:entry id="N11280" part="chapter3" ref="N11280" type="pagenumber">39</cms:entry><cms:entry id="_1064832012" part="chapter3" ref="_1064832012" type="link"/><cms:entry id="N1128A" part="chapter3" ref="N1128A" type="mm">415#301</cms:entry><cms:entry id="N11298" part="chapter3" ref="N11298" type="table"/><cms:entry id="N112FD" part="chapter3" ref="N112FD" type="pagenumber">40</cms:entry><cms:entry id="_1064832410" part="chapter3" ref="_1064832410" type="link"/><cms:entry id="N11307" part="chapter3" ref="N11307" type="mm">415#301</cms:entry><cms:entry id="N11315" part="chapter3" ref="N11315" type="table"/><cms:entry id="N1137A" part="chapter3" ref="N1137A" type="pagenumber">41</cms:entry><cms:entry id="N11384" part="chapter3" ref="N11384" type="table"/><cms:entry id="N11514" part="chapter3" ref="N11514" type="mm">175#175</cms:entry><cms:entry id="N1151F" part="chapter3" ref="N1151F" type="mm">175#175</cms:entry><cms:entry id="N11529" part="chapter3" ref="N11529" type="block">3.2.2.2</cms:entry><cms:entry id="N1152D" part="chapter3" ref="N1152D" type="pagenumber">42</cms:entry><cms:entry id="_1064836699" part="chapter3" ref="_1064836699" type="link"/><cms:entry id="_1064928385" part="chapter3" ref="_1064928385" type="link"/><cms:entry id="N1153D" part="chapter3" ref="N1153D" type="mm">415#301</cms:entry><cms:entry id="N1154B" part="chapter3" ref="N1154B" type="table"/><cms:entry id="N115F2" part="chapter3" ref="N115F2" type="pagenumber">43</cms:entry><cms:entry id="_1064832126" part="chapter3" ref="_1064832126" type="link"/><cms:entry id="_1064928429" part="chapter3" ref="_1064928429" type="link"/><cms:entry id="N115FF" part="chapter3" ref="N115FF" type="mm">415#301</cms:entry><cms:entry id="N1160D" part="chapter3" ref="N1160D" type="table"/><cms:entry id="N116BA" part="chapter3" ref="N116BA" type="pagenumber">44</cms:entry><cms:entry id="N116C4" part="chapter3" ref="N116C4" type="table"/><cms:entry id="N11854" part="chapter3" ref="N11854" type="table"/><cms:entry id="N119E4" part="chapter3" ref="N119E4" type="subsection">3.2.3</cms:entry><cms:entry id="N119E8" part="chapter3" ref="N119E8" type="pagenumber">45</cms:entry><cms:entry id="N119ED" part="chapter3" ref="N119ED" type="block">3.2.3.1</cms:entry><cms:entry id="_1064896773" part="chapter3" ref="_1064896773" type="link"/><cms:entry id="_1064928443" part="chapter3" ref="_1064928443" type="link"/><cms:entry id="N119FD" part="chapter3" ref="N119FD" type="mm">415#301</cms:entry><cms:entry id="N11A0B" part="chapter3" ref="N11A0B" type="table"/><cms:entry id="N11A70" part="chapter3" ref="N11A70" type="pagenumber">46</cms:entry><cms:entry id="_1064896858" part="chapter3" ref="_1064896858" type="link"/><cms:entry id="N11A7A" part="chapter3" ref="N11A7A" type="mm">415#301</cms:entry><cms:entry id="N11A88" part="chapter3" ref="N11A88" type="table"/><cms:entry id="N11AED" part="chapter3" ref="N11AED" type="pagenumber">47</cms:entry><cms:entry id="N11AF4" part="chapter3" ref="N11AF4" type="mm">415#301</cms:entry><cms:entry id="N11B02" part="chapter3" ref="N11B02" type="table"/><cms:entry id="N11B67" part="chapter3" ref="N11B67" type="pagenumber">48</cms:entry><cms:entry id="_1064897498" part="chapter3" ref="_1064897498" type="link"/><cms:entry id="N11B71" part="chapter3" ref="N11B71" type="mm">415#301</cms:entry><cms:entry id="N11B7F" part="chapter3" ref="N11B7F" type="table"/><cms:entry id="N11BE4" part="chapter3" ref="N11BE4" type="pagenumber">49</cms:entry><cms:entry id="_1064897744" part="chapter3" ref="_1064897744" type="link"/><cms:entry id="N11BEE" part="chapter3" ref="N11BEE" type="mm">415#301</cms:entry><cms:entry id="N11BFC" part="chapter3" ref="N11BFC" type="table"/><cms:entry id="N11C60" part="chapter3" ref="N11C60" type="block">3.2.3.2</cms:entry><cms:entry id="N11C64" part="chapter3" ref="N11C64" type="pagenumber">50</cms:entry><cms:entry id="_1064928484" part="chapter3" ref="_1064928484" type="link"/><cms:entry id="N11C71" part="chapter3" ref="N11C71" type="mm">415#301</cms:entry><cms:entry id="N11C7E" part="chapter3" ref="N11C7E" type="table"/><cms:entry id="N11D31" part="chapter3" ref="N11D31" type="pagenumber">51</cms:entry><cms:entry id="_1064928567" part="chapter3" ref="_1064928567" type="link"/><cms:entry id="N11D3B" part="chapter3" ref="N11D3B" type="mm">415#301</cms:entry><cms:entry id="N11D49" part="chapter3" ref="N11D49" type="table"/><cms:entry id="N11DF9" part="chapter3" ref="N11DF9" type="pagenumber">52</cms:entry><cms:entry id="N11E00" part="chapter3" ref="N11E00" type="mm">412#328</cms:entry><cms:entry id="N11E0E" part="chapter3" ref="N11E0E" type="table"/><cms:entry id="N11EBB" part="chapter3" ref="N11EBB" type="pagenumber">53</cms:entry><cms:entry id="_1064928682" part="chapter3" ref="_1064928682" type="link"/><cms:entry id="N11EC5" part="chapter3" ref="N11EC5" type="mm">415#301</cms:entry><cms:entry id="N11ED3" part="chapter3" ref="N11ED3" type="table"/><cms:entry id="N11F80" part="chapter3" ref="N11F80" type="pagenumber">54</cms:entry><cms:entry id="_1064928846" part="chapter3" ref="_1064928846" type="link"/><cms:entry id="N11F8A" part="chapter3" ref="N11F8A" type="mm">415#301</cms:entry><cms:entry id="N11F98" part="chapter3" ref="N11F98" type="table"/><cms:entry id="N12045" part="chapter3" ref="N12045" type="subsection">3.2.4</cms:entry><cms:entry id="N12049" part="chapter3" ref="N12049" type="pagenumber">55</cms:entry><cms:entry id="N1204E" part="chapter3" ref="N1204E" type="block">3.2.4.1</cms:entry><cms:entry id="_1064933492" part="chapter3" ref="_1064933492" type="link"/><cms:entry id="N1205B" part="chapter3" ref="N1205B" type="mm">415#301</cms:entry><cms:entry id="N12069" part="chapter3" ref="N12069" type="table"/><cms:entry id="N120CE" part="chapter3" ref="N120CE" type="pagenumber">56</cms:entry><cms:entry id="_1064933610" part="chapter3" ref="_1064933610" type="link"/><cms:entry id="N120D8" part="chapter3" ref="N120D8" type="mm">415#301</cms:entry><cms:entry id="N120E6" part="chapter3" ref="N120E6" type="table"/><cms:entry id="N1214B" part="chapter3" ref="N1214B" type="pagenumber">57</cms:entry><cms:entry id="_1064933790" part="chapter3" ref="_1064933790" type="link"/><cms:entry id="N12155" part="chapter3" ref="N12155" type="mm">415#301</cms:entry><cms:entry id="N12163" part="chapter3" ref="N12163" type="table"/><cms:entry id="N121C8" part="chapter3" ref="N121C8" type="pagenumber">58</cms:entry><cms:entry id="_1064943186" part="chapter3" ref="_1064943186" type="link"/><cms:entry id="N121D2" part="chapter3" ref="N121D2" type="mm">415#301</cms:entry><cms:entry id="N121E0" part="chapter3" ref="N121E0" type="table"/><cms:entry id="N12245" part="chapter3" ref="N12245" type="pagenumber">59</cms:entry><cms:entry id="N1224F" part="chapter3" ref="N1224F" type="table"/><cms:entry id="N123DF" part="chapter3" ref="N123DF" type="mm">175#175</cms:entry><cms:entry id="N123EA" part="chapter3" ref="N123EA" type="mm">175#175</cms:entry><cms:entry id="N123F7" part="chapter3" ref="N123F7" type="block">3.2.4.2</cms:entry><cms:entry id="N123FB" part="chapter3" ref="N123FB" type="pagenumber">60</cms:entry><cms:entry id="_1064933858" part="chapter3" ref="_1064933858" type="link"/><cms:entry id="N12408" part="chapter3" ref="N12408" type="mm">415#301</cms:entry><cms:entry id="N12416" part="chapter3" ref="N12416" type="table"/><cms:entry id="N124C3" part="chapter3" ref="N124C3" type="pagenumber">61</cms:entry><cms:entry id="N124CA" part="chapter3" ref="N124CA" type="mm">415#301</cms:entry><cms:entry id="N124D8" part="chapter3" ref="N124D8" type="table"/><cms:entry id="N12585" part="chapter3" ref="N12585" type="pagenumber">62</cms:entry><cms:entry id="_1064934027" part="chapter3" ref="_1064934027" type="link"/><cms:entry id="N1258F" part="chapter3" ref="N1258F" type="mm">415#301</cms:entry><cms:entry id="N1259D" part="chapter3" ref="N1259D" type="table"/><cms:entry id="N1264A" part="chapter3" ref="N1264A" type="pagenumber">63</cms:entry><cms:entry id="N12657" part="chapter3" ref="N12657" type="table"/><cms:entry id="N127E7" part="chapter3" ref="N127E7" type="table"/><cms:entry id="N12977" part="chapter3" ref="N12977" type="subsection">3.2.5</cms:entry><cms:entry id="N1297B" part="chapter3" ref="N1297B" type="pagenumber">64</cms:entry><cms:entry id="N12980" part="chapter3" ref="N12980" type="block">3.2.5.1</cms:entry><cms:entry id="N1298A" part="chapter3" ref="N1298A" type="table"/><cms:entry id="N12ACD" part="chapter3" ref="N12ACD" type="mm">576#277</cms:entry><cms:entry id="N12AD8" part="chapter3" ref="N12AD8" type="pagenumber">65</cms:entry><cms:entry id="N12AE2" part="chapter3" ref="N12AE2" type="table"/><cms:entry id="N12BE8" part="chapter3" ref="N12BE8" type="mm">550#288</cms:entry><cms:entry id="N12BF2" part="chapter3" ref="N12BF2" type="block">3.2.5.2</cms:entry><cms:entry id="N12BF6" part="chapter3" ref="N12BF6" type="pagenumber">66</cms:entry><cms:entry id="N12C00" part="chapter3" ref="N12C00" type="table"/><cms:entry id="N12D53" part="chapter3" ref="N12D53" type="mm">566#288</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N12D64" part="chapter4" ref="N12D64" type="pagenumber">67</cms:entry><cms:entry id="N12D69" part="chapter4" ref="N12D69" type="section">4.1</cms:entry><cms:entry id="N12D79" part="chapter4" ref="N12D79" type="pagenumber">68</cms:entry><cms:entry id="N12D82" part="chapter4" ref="N12D82" type="section">4.2</cms:entry><cms:entry id="N12D87" part="chapter4" ref="N12D87" type="subsection">4.2.1</cms:entry><cms:entry id="N12DBB" part="chapter4" ref="N12DBB" type="subsection">4.2.2</cms:entry><cms:entry id="N12DBF" part="chapter4" ref="N12DBF" type="pagenumber">69</cms:entry><cms:entry id="N12E05" part="chapter4" ref="N12E05" type="pagenumber">70</cms:entry><cms:entry id="N12E3C" part="chapter4" ref="N12E3C" type="pagenumber">71</cms:entry><cms:entry id="N12E44" part="chapter4" ref="N12E44" type="subsection">4.2.3</cms:entry><cms:entry id="N12E48" part="chapter4" ref="N12E48" type="pagenumber">72</cms:entry><cms:entry id="N12E8E" part="chapter4" ref="N12E8E" type="pagenumber">73</cms:entry><cms:entry id="N12EAE" part="chapter4" ref="N12EAE" type="pagenumber">74</cms:entry><cms:entry id="N12EC6" part="chapter4" ref="N12EC6" type="subsection">4.2.4</cms:entry><cms:entry id="N12EE3" part="chapter4" ref="N12EE3" type="pagenumber">75</cms:entry><cms:entry id="N12F00" part="chapter4" ref="N12F00" type="pagenumber">76</cms:entry><cms:entry id="N12F14" part="chapter4" ref="N12F14" type="subsection">4.2.5</cms:entry><cms:entry id="N12F18" part="chapter4" ref="N12F18" type="pagenumber">77</cms:entry><cms:entry id="N12F52" part="chapter4" ref="N12F52" type="pagenumber">78</cms:entry><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N12F62" part="chapter5" ref="N12F62" type="pagenumber">79</cms:entry><cms:entry id="N12F72" part="chapter5" ref="N12F72" type="table"/><cms:entry id="N1307B" part="chapter5" ref="N1307B" type="table"/><cms:entry id="N13082" part="chapter5" ref="N13082" type="pagenumber">80</cms:entry><cms:entry ref="N1323F" type="back"/><cms:entry id="N13241" part="N13241" ref="N13241" type="abbreviation">
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				Literaturverzeichnis</cms:entry><cms:entry id="N13674" part="N13670" ref="N13674" type="pagenumber">83</cms:entry><cms:entry id="_Ref1" part="N13670" ref="_Ref1" type="citation"/><cms:entry id="_Ref2" part="N13670" ref="_Ref2" type="citation"/><cms:entry id="_Ref3" part="N13670" ref="_Ref3" type="citation"/><cms:entry id="_Ref4" part="N13670" ref="_Ref4" type="citation"/><cms:entry id="_Ref5" part="N13670" ref="_Ref5" type="citation"/><cms:entry id="_Ref6" part="N13670" ref="_Ref6" type="citation"/><cms:entry id="_Ref7" part="N13670" ref="_Ref7" type="citation"/><cms:entry id="_Ref8" part="N13670" ref="_Ref8" type="citation"/><cms:entry id="_Ref9" part="N13670" ref="_Ref9" type="citation"/><cms:entry id="_Ref10" part="N13670" ref="_Ref10" type="citation"/><cms:entry id="_Ref11" part="N13670" ref="_Ref11" type="citation"/><cms:entry id="_Ref12" part="N13670" ref="_Ref12" type="citation"/><cms:entry id="N137E9" part="N13670" ref="N137E9" type="pagenumber">84</cms:entry><cms:entry 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				Eidesstattliche Erklärung</cms:entry><cms:entry id="N1417C" part="N14178" ref="N1417C" type="pagenumber">93</cms:entry><cms:entry part="front" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><front id="front"><school>
			Aus der Klinik für Kardiovasculäre Chirurgie <br/>der Medizinischen Fakultät der Charité - Universitätsmedizin Berlin</school><submission>Dissertation</submission><title>Beurteilung der<br/>linksventrikulären Funktion nach<br/>Partieller Ventrikulektomie<br/>mittels Stressechokardiographie</title><degree>Zur Erlangung des akademischen Grades Doctor medicinae (Dr.med.)</degree><major>vorgelegt der Medizinischen Fakultät der Charité-<br/>Universitätsmedizin Berlin</major><author>von<br/>
			<given>Johanna </given>
			<surname>Seysen</surname>
			<suffix>aus Buchholz i. d. Nordheide</suffix>
		</author><p>
			
		</p><dean>Prof. Dr. med. Martin Paul</dean><approvals>
			<name>Prof. Dr. med. W. Konertz</name>
			<name>PD Dr. med. A. Schiessler</name>
			<name>PD Dr. med. B. Schubel</name>
		</approvals><date>Datum der Promotion: 06.09.2004 </date><abstract lang="de">
			<head>
				Kurzfassung</head>
			<p>
				<strong>Ziel:</strong> Die partielle Ventrikulektomie (PLV) stellt eine chirurgische Therapieoption der terminalen Herzinsuffizienz dar. In dieser Arbeit wurde der Einfluss der PLV auf die kardiale Leistungsfähigkeit untersucht sowie eine Überlebensanalyse durchgeführt. Ferner sollte eine Aussage zum Verhalten der postoperativen linksventrikulären Funktion unter Belastung gemacht werden. Dabei wurden zwei Gruppen miteinander verglichen: 1. Patienten mit idiopathischer Kardiomyopathie (Gruppe ID) und 2. Patienten mit ischämischer Myopathie (Gruppe IS).</p>
			<p>
				<strong>Material und Methodik:</strong> Insgesamt wurden 75 Patienten, die sich im Zeitraum von 1995 bis 1999 in der Klinik für Kardiovaskuläre Chirurgie der Charité einer PLV unterzogen hatten, berücksichtigt. Die postoperativen Untersuchungen erfolgten an 19 Patienten. Die linksventrikulären Funktionsparameter wurden mittels transthorakaler und transösophagealer Echokardiographie einschließlich Stressechokardiographie erhoben.</p>
			<p>
				<strong>Ergebnisse:</strong> In beiden Gruppen war postoperativ eine hochsignifikante Verbesserung der NYHA-Klassifikation zu registrieren. Die echokardiographischen Untersuchungen ergaben in beiden Gruppen eine Verbesserung der Ejektionsfraktion (EF) als Maß für die linksventrikuläre Funktion. Ferner war eine Verringerung des linksventrikulären enddiastolischen Durchmessers (LVEDD) und ein signifikanter Rückgang der Mitralinsuffizienz (MI) festzustellen. Die Stressechokardiographie zeigte für die Gruppe IS eine Steigerung der Kontraktilität unter Dobutamin mit tendenziell physiologischen Befunden. (signifikanter Anstieg von EF, cardiac index (CI), fractional area change (FAC) sowie Abnahme des linksventrikulären endsystolischen Volumenindex (LVESVI)). Für die Gruppe ID konnte dies nur bedingt gezeigt werden. Bei der Überlebensanalyse ergaben sich ebenfalls ein signifikant besseres Abschneiden der Gruppe IS, insgesamt lag die Überlebensrate hinsichtlich kardialer Todesursachen bei 69,9 % (1. Jahr) und 66,7 % (2. Jahr).</p>
			<p>
				<strong>Schlussfolgerungen:</strong> Beurteilend lässt sich feststellen, dass die überlebenden und zur Nachuntersuchung erschienenen Patienten mit einer Steigerung der körperlichen Belastbarkeit und Besserung der Ventrikelfunktionsparameter von der Operation profitieren konnten, wobei sich ein besseres Abschneiden der Gruppe IS zeigte. Dazu passend wies auch die stressechokardiographische Untersuchung vor allem für die Gruppe IS postoperativ auf myokardiale Reserven hin. Die hier aufgezeigten Unterschiede der Gruppen, die sich auch in den Überlebensraten widerspiegeln, machen die Bedeutung von guten Selektionskriterien deutlich, die in weiteren Studien noch differenzierter betrachtet werden müssen. Damit zusammenhängend kommt auch der Anpassung der mit der PLV kombinierten Eingriffe an die Ursachen der Myopathien besondere Wichtigkeit zu.</p>
		</abstract><keywords lang="de">
			<keyword>Partielle Ventrikulektomie (PLV)</keyword>
			<keyword>terminale Herzinsuffizienz</keyword>
			<keyword>dilatative Kardiomyopathie (DCMP)</keyword>
			<keyword>Stressechokardiographie</keyword>
		</keywords><abstract lang="en">
			<head>Abstract</head>
			<p>
				<strong>Aim:</strong> Partial left ventriculectomy (PLV) represents a surgical option for the treatment of end-stage-heart failure. The aim of this thesis was an investigation of the influence of PLV on LV-function and on clinical outcome and to analyse survival in a group of patients submitted to PLV: Also, post surgical left ventricular function under stress conditions was determined. Two groups served as a basis for comparison: 1. patients with idiopathic dilated cardiomyopathy (ID group) and 2. patients with ischemic myopathy (IS group). </p>
			<p>
				<strong>Methods:</strong> 75 patients undergoing PLV at the clinic for cardiovascular surgery at the Charité Berlin between 1995 and 1999 were considered. LV-function was determined by transthoracic and transesophageal echocardiography including stress echocardiography. </p>
			<p>
				<strong>Results:</strong> The NYHA-classification improved in both groups significantly after the surgery. The echocardiography showed a significant increase in ejection fraction (EF), a reduction of left ventricular enddiastolic diameter (LVEDD) and a significant decrease in mitral insufficiency (MI). The post surgical stress-echocardiography indicated a rise of left ventricular contractility under dobutamine with a tendency to physiological results (significant increase in EF, cardiac index (CI), fractional area change (FAC) and decrease in left ventricular enddiastolic volume index (LVEDVI)) in the IS group. Concerning the ID group, these results were only partially valid. Looking at the survival rates it turned out that they are significantly higher for the IS group than for the ID group. All in all, 1-year-survival was at 69,9 % and 2-year-survival was at 66,7 %. </p>
			<p>
				<strong>Conclusion:</strong> It can be concluded that survivors profited from the surgery which is shown by the improvement of physical capacity and left ventricular parameters. This applies especially to patients from the IS group, which conforms to the fact that also the post surgical stress echocardiography revealed myocardial reserves for this group. The differences between the groups which have been demonstrated in these investigations and which are also reflected in survival rates stress the importance of carefully chosen selection criteria and the need for further subtly differentiated research in this special field. Considering this, also the correlation between the intervention combined with PLV and the cause of the myopathy is of great importance.</p>
		</abstract><keywords lang="en">
			<keyword>partial left ventriculectomy (PLV)</keyword>
			<keyword>heart failure</keyword>
			<keyword>dilatative cardiomyopathy (DCMP)</keyword>
			<keyword>stress echocardiography</keyword>
		</keywords><freehead id=":contents">Inhaltsverzeichnis</freehead><ul><li><p><link ref="chapter1">1</link> 
				
				Einleitung<ul><li><p><link ref="N100D2">1.1</link> Krankheitsbild<ul><li><p><link ref="N100DA">1.1.1</link> Grundlagen und Klinik der Herzinsuffizienz</p></li><li><p><link ref="N1018C">1.1.2</link> Kardiomyopathie</p></li></ul></p></li><li><p><link ref="N101EA">1.2</link> 
					Diagnostik<ul><li><p><link ref="N102A1">1.2.1</link> Bedeutung der Echokardiographie</p></li></ul></p></li><li><p><link ref="N102C8">1.3</link> 
					Therapie<ul><li><p><link ref="N102D8">1.3.1</link> Medikamentöse Therapie </p></li><li><p><link ref="N102E9">1.3.2</link> Chirurgische Therapie</p></li><li><p><link ref="N10356">1.3.3</link> Die partielle Ventrikulektomie nach Batista</p></li></ul></p></li><li><p><link ref="N1051C">1.4</link> 
					Beschreibung des Arbeitsziels</p></li></ul></p></li><li><p><link ref="chapter2">2</link> 
				Material und Methode<ul><li><p><link ref="N1055B">2.1</link> Datenerfassung <ul><li><p><link ref="N10681">2.1.1</link> 
						Erläuterung der erfassten Daten </p></li></ul></p></li><li><p><link ref="N107D1">2.2</link> 
					Patienten und Gruppenbildung<ul><li><p><link ref="N107DA">2.2.1</link> Auswahl der Patienten</p></li><li><p><link ref="N107E3">2.2.2</link> Kollektivbeschreibung</p></li><li><p><link ref="N109C0">2.2.3</link> 
						Gruppeneinteilung</p></li></ul></p></li><li><p><link ref="N10A31">2.3</link> 
					Operationsmethode<ul><li><p><link ref="N10A3A">2.3.1</link> Operationsablauf der PLV </p></li><li><p><link ref="N10A66">2.3.2</link> 
						Zusätzliche Eingriffe</p></li></ul></p></li><li><p><link ref="N10B68">2.4</link> 
					Nachuntersuchung<ul><li><p><link ref="N10B71">2.4.1</link> Untersuchungsablauf</p></li><li><p><link ref="N10BCE">2.4.2</link> Methodik und Durchführung der Echokardiographie<ul><li><p><link ref="N10BD3">2.4.2.1</link> Transthorakale echokardiographische Messungen (TTE)</p></li><li><p><link ref="N10C9D">2.4.2.2</link> 
							Transösophageale echokardiographische Messungen (TEE)</p></li></ul></p></li></ul></p></li><li><p><link ref="N10D61">2.5</link> 
					Statistik und Datenverarbeitung</p></li></ul></p></li><li><p><link ref="chapter3">3</link> 
				Ergebnisse<ul><li><p><link ref="N10D87">3.1</link> Selektion der Ergebnisse</p></li><li><p><link ref="N10D90">3.2</link> Darstellung der Ergebnisse<ul><li><p><link ref="N10D9E">3.2.1</link> 
						Prä- und postoperative NYHA-Klassifikation<ul><li><p><link ref="N10DA7">3.2.1.1</link> Gesamtkollektiv</p></li><li><p><link ref="N10F29">3.2.1.2</link> 
							Gegenüberstellung der Untergruppen</p></li></ul></p></li><li><p><link ref="N111F7">3.2.2</link> 
						Prä- und postoperative Echokardiographiebefunde<ul><li><p><link ref="N11203">3.2.2.1</link> Gesamtkollektiv</p></li><li><p><link ref="N11529">3.2.2.2</link> 
							Gegenüberstellung der Untergruppen </p></li></ul></p></li><li><p><link ref="N119E4">3.2.3</link> 
						Transthorakale Stressechokardiographie <ul><li><p><link ref="N119ED">3.2.3.1</link> Gesamtkollektiv</p></li><li><p><link ref="N11C60">3.2.3.2</link> 
							Gegenüberstellung der Untergruppen</p></li></ul></p></li><li><p><link ref="N12045">3.2.4</link> 
						Transösophageale Stressechokardiographie <ul><li><p><link ref="N1204E">3.2.4.1</link> Gesamtkollektiv</p></li><li><p><link ref="N123F7">3.2.4.2</link> 
							Gegenüberstellung der Untergruppen</p></li></ul></p></li><li><p><link ref="N12977">3.2.5</link> 
						Darstellung der Überlebenszeiten<ul><li><p><link ref="N12980">3.2.5.1</link> Gesamtkollektiv</p></li><li><p><link ref="N12BF2">3.2.5.2</link> 
							Gegenüberstellung der Untergruppen</p></li></ul></p></li></ul></p></li></ul></p></li><li><p><link ref="chapter4">4</link> 
				Diskussion<ul><li><p><link ref="N12D69">4.1</link> Diskussion zu Material und Methode</p></li><li><p><link ref="N12D82">4.2</link> Diskussion der Ergebnisse<ul><li><p><link ref="N12D87">4.2.1</link> Prä- und postoperative NYHA-Klassifikation</p></li><li><p><link ref="N12DBB">4.2.2</link> 
						Prä- und postoperative Echokardiographiebefunde</p></li><li><p><link ref="N12E44">4.2.3</link> 
						Transthorakale Stressechokardiographie</p></li><li><p><link ref="N12EC6">4.2.4</link> Transösophageale Stressechokardiographie</p></li><li><p><link ref="N12F14">4.2.5</link> 
						Überlebensfunktionen</p></li></ul></p></li></ul></p></li><li><p><link ref="chapter5">5</link> 
				Zusammenfassung</p></li><li><p><link ref="N13241">
				Abkürzungsverzeichnis</link></p></li><li><p><link ref="N13670">
				Literaturverzeichnis</link></p></li><li><p><link ref="N13F97">
				Lebenslauf</link></p></li><li><p><link ref="N1415F">
				Danksagung</link></p></li><li><p><link ref="N14178">
				Eidesstattliche Erklärung</link></p></li></ul><freehead id=":toc-tables">Tabellen</freehead><ul><li><p><link ref="N100FE">Tab. 1: Stadieneinteilung der Herzinsuffizienz nach NYHA</link></p></li><li><p><link ref="N101FB">
							Tab. 2: Linksventrikuläre Parameter und ihre Normwerte [nach 16]</link></p></li><li><p><link ref="N10583">
							Tab. 4: Erfasste Daten dieser Arbeit</link></p></li><li><p><link ref="N10809">Tab. 5: Vorerkrankungen</link></p></li><li><p><link ref="N10924">Tab. 6: Kardiale Voroperationen</link></p></li><li><p><link ref="N10A74">Tab. 7: Zusätzliche Eingriffe zur PLV</link></p></li><li><p><link ref="N10C27">Tab. 8: Bewertung des Pulmonalarteriendruckes [42]</link></p></li><li><p><link ref="N10CC3">Tab. 9: Quantifizierung der Mitralinsuffizienz</link></p></li><li><p><link ref="N10DB1">Tab. 10: NYHA-Klassifikation</link></p></li><li><p><link ref="N10F37">Tab. 11: präoperative Verteilung der NYHA-Klassifikation in den Untergruppen </link></p></li><li><p><link ref="N11097">Tab. 12: postoperative Verteilung der NYHA-Klassifikation in den Untergruppen</link></p></li><li><p><link ref="N1121B">Tab. 13: Vergleich LA-Durchmesser prä- und postoperativ </link></p></li><li><p><link ref="N11298">Tab. 14: Vergleich LVEDD prä- und postoperativ</link></p></li><li><p><link ref="N11315">Tab. 15: Vergleich EF prä- und postoperativ</link></p></li><li><p><link ref="N11384">Tab. 16: Verteilung der Mitralinsuffizienz prä- und postoperativ</link></p></li><li><p><link ref="N1154B">Tab. 17: Vergleich LVEDD prä- und postoperativ in den Untergruppen</link></p></li><li><p><link ref="N1160D">Tab. 18: Vergleich EF prä- und postoperativ in den Untergruppen</link></p></li><li><p><link ref="N116C4">Tab. 19: präoperative Verteilung der MI in den Untergruppen</link></p></li><li><p><link ref="N11854">Tab. 20: postoperative Verteilung der MI in den Untergruppen</link></p></li><li><p><link ref="N11A0B">Tab. 21: Vergleich LVESVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11A88">Tab. 22: Vergleich LVEDVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11B02">Tab. 23: Vergleich EF Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11B7F">Tab. 24: Vergleich SVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11BFC">Tab. 25: Vergleich CI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11C7E">Tab. 26: Vergleich LVESVI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11D49">Tab. 27: Vergleich LVEDVI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11E0E">Tab. 28: EF Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11ED3">Tab. 29: Vergleich SVI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11F98">Tab. 30: Vergleich CI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N12069">Tab. 31: Vergleich EDA Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N120E6">Tab. 32: Vergleich ESA Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N12163">Tab. 33: Vergleich FAC Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N121E0">Tab. 34: Vergleich Jetfläche/Vorhoffläche Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N1224F">Tab. 35: Verteilung der MI in Ruhe und unter Dobutamin</link></p></li><li><p><link ref="N12416">Tab. 36: Vergleich EDA Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N124D8">Tab. 37: Vergleich ESA Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N1259D">Tab. 38: Vergleich FAC Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N12657">Tab. 39: Verteilung der MI in Ruhe in den Untergruppen</link></p></li><li><p><link ref="N127E7">Tab. 40: Verteilung der MI unter Dobutaminbelastung in den Untergruppen</link></p></li><li><p><link ref="N1298A">Tab. 41: Mortalität, Todesursachen und Überlebensraten Gesamtkollektiv</link></p></li><li><p><link ref="N12AE2">Tab. 42: Überlebensrate mit und ohne ICD</link></p></li><li><p><link ref="N12C00">Tab. 43: Mortalität, Todesursachen und Überlebensraten der Gruppen IS und ID</link></p></li><li><p><link ref="N12F72">Tab. 44: prä- und postoperative Echokardiographieparameter</link></p></li><li><p><link ref="N1307B">
						Tab. 45: Ergebnisse der postoperativen Stressechokardiographie</link></p></li></ul><freehead id=":toc-media">Bilder</freehead><ul><li><p><link ref="N10A47">Abb. 1: Interpapilläre Resektion [33]</link></p></li><li><p><link ref="N10BEA">Abb. 2: Simpson-Rolle [nach 42]</link></p></li><li><p><link ref="N10F11">Abb. 3: NYHA-Klassen präoperativ</link></p></li><li><p><link ref="N10F1C">Abb. 4: NYHA-Klassen postoperativ</link></p></li><li><p><link ref="N1120D">Abb. 5: LA-Durchmesser prä- und postoperativ</link></p></li><li><p><link ref="N1128A">Abb. 6: LVEDD prä- und postoperativ</link></p></li><li><p><link ref="N11307">Abb. 7: EF prä- und postoperativ</link></p></li><li><p><link ref="N11514">Abb. 8: Mitralinsuffizienz präoperativ</link></p></li><li><p><link ref="N1151F">Abb. 9: Mitralinsuffizienz postoperativ</link></p></li><li><p><link ref="N1153D">Abb. 10: LVEDD prä- und postoperativ in den Untergruppen</link></p></li><li><p><link ref="N115FF">Abb. 11: EF prä- und postoperativ in den Untergruppen</link></p></li><li><p><link ref="N119FD">Abb. 12: LVESVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11A7A">Abb. 13: LVEDVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11AF4">Abb. 14: EF Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11B71">Abb. 15: SVI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11BEE">Abb. 16: CI Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N11D3B">Abb. 18: LVEDVI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11E00">Abb. 19: EF Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11EC5">Abb. 20: SVI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N11F8A">Abb. 21: CI Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N1205B">Abb. 22: EDA Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N120D8">Abb. 23: ESA Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N12155">Abb. 24: FAC Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N121D2">Abb. 25: Jetfläche/Vorhoffläche Ruhe &#8212; Dobutamin</link></p></li><li><p><link ref="N123DF">Abb. 26: Verteilung MI Ruhe</link></p></li><li><p><link ref="N123EA">Abb. 27: Verteilung MI Dobutamin</link></p></li><li><p><link ref="N12408">Abb. 28: EDA Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N124CA">Abb. 29: ESA Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N1258F">Abb. 30: FAC Ruhe &#8212; Dobutamin in den Untergruppen</link></p></li><li><p><link ref="N12ACD">Abb. 31: Überlebensfunktion Gesamtkollektiv</link></p></li><li><p><link ref="N12BE8">Abb. 32: Überlebensfunktion von Patienten mit und ohne ICD</link></p></li><li><p><link ref="N12D53">Abb. 33: Überlebensfunktionen der Untergruppen</link></p></li></ul></front></cms:content></cms:document></cms:container>